19,569 results match your criteria Ectopic Pregnancy


Exosomal MicroRNAs in Serum as Potential Biomarkers for Ectopic Pregnancy.

Biomed Res Int 2020 11;2020:3521859. Epub 2020 Jun 11.

Lingnan Medical Research Center of Guangzhou University of Chinese Medicine, Guangzhou 510000, China.

Design: From July 2016 to June 2018, 36 women with symptomatic early pregnancy around 4-8 weeks of gestation were recruited into the study. Among them, there were 16 women with viable intrauterine pregnancy (VIP), 9 women with spontaneous abortion (SA), and 11 women of EP. Serum exosomal miRNAs were extracted and measured at the first prenatal visit. Read More

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http://dx.doi.org/10.1155/2020/3521859DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7305552PMC

Letrozole: future alternative to methotrexate for treatment of ectopic pregnancy?

Fertil Steril 2020 Jul 1. Epub 2020 Jul 1.

Institut national de santé publique du Québec, Montreal, Quebec, Canada; Department of Obstetrics and Gynecology, Sainte-Justine Hospital Research Center, University of Montreal, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1016/j.fertnstert.2020.04.063DOI Listing

Aromatase inhibitor letrozole: a novel treatment for ectopic pregnancy.

Fertil Steril 2020 Jul 1. Epub 2020 Jul 1.

Biotechnology and Life Sciences Department, Faculty of Postgraduate Studies for Advanced Sciences, Beni-Suef University, Beni-Suef, Egypt.

Objective: To study the use of the aromatase inhibitor letrozole for treatment of ectopic pregnancy compared with methotrexate.

Design: Nonrandomized prospective cohort study.

Setting: University hospital. Read More

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http://dx.doi.org/10.1016/j.fertnstert.2020.04.001DOI Listing

Methotrexate impaired in-vivo matured mouse oocyte quality and the possible mechanisms.

BMC Mol Cell Biol 2020 Jul 3;21(1):51. Epub 2020 Jul 3.

State Key Laboratory of Low-Dimensional Quantum Physics, Department of Physics, Tsinghua University, Haidian District, Beijing, 100084, China.

Background: Methotrexate (MTX) is an antifolate agent which is widely used in clinic for treating malignancies, rheumatoid arthritis and ectopic pregnancy. As reported, MTX has side effects on gastrointestinal system, nervous system and reproductive system, while its potential damages on oocyte quality are still unclear. It is known that oocyte quality is essential for healthy conception and the forthcoming embryo development. Read More

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http://dx.doi.org/10.1186/s12860-020-00298-7DOI Listing

High-risk third trimester pregnancy with decompensated cirrhosis safely delivered following emergent preoperative interventional radiology for mitigation of variceal bleeding.

Clin Imaging 2020 Jun 18;68:143-147. Epub 2020 Jun 18.

Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, NC, USA. Electronic address:

Coagulopathy coupled with severe portal hypertension in the setting of cirrhosis increases the risk of mortality from variceal bleeding in pregnant women. Studies suggest transjugular intrahepatic portosystemic shunt (TIPS) creation to be a safe procedure during pregnancy in preventing variceal bleeding complications; however, it is not typically employed in severely decompensated cirrhosis. This case report of a pregnant woman presenting at 34. Read More

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http://dx.doi.org/10.1016/j.clinimag.2020.06.032DOI Listing

False-positive pregnancy test secondary to ectopic expression of human chorionic gonadotropin by a gastrointestinal stromal tumor.

J Surg Oncol 2020 Jul 2. Epub 2020 Jul 2.

Department of Radiation Oncology, Washington University School of Medicine, St. Louis, Missouri.

Tumors can rarely overexpress human chorionic gonadotropin (hCG) resulting in false-positive pregnancy tests. Here, we report a 44-year-old female with a metastatic gastrointestinal stromal tumor (GIST) who presented with a positive urine pregnancy test before radiotherapy. Further workup ruled out pregnancy. Read More

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http://dx.doi.org/10.1002/jso.26067DOI Listing

Interventions for non-tubal ectopic pregnancy.

Cochrane Database Syst Rev 2020 Jul 1;7:CD011174. Epub 2020 Jul 1.

Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu, China.

Background: Non-tubal ectopic pregnancy is the implantation of an embryo at a site lying outside the uterine cavity or fallopian tubes. Sites include a caesarean scar, the cornua uteri, the ovary, the cervix, and the abdomen. There has been an increasing trend in the occurrence of these rare conditions, especially caesarean scar pregnancy (CSP). Read More

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http://dx.doi.org/10.1002/14651858.CD011174.pub2DOI Listing

Two Cases of Ectopic Pregnancy Mimicking Gestational Trophoblastic Disease.

Case Rep Obstet Gynecol 2020 16;2020:2417428. Epub 2020 Jun 16.

Department of Gynecology and Obstetrics, Kyoto University, 54 Shogoin Kawahara-cho, Sakyo, Kyoto 606-8507, Japan.

A well-known typical feature of ectopic pregnancy is an evident gestational sac structure outside of the uterus. However, some cases show atypical appearance that is described as a heterogeneous hypervascular mass. We report two cases of ectopic pregnancy that presented heterogeneous findings mimicking gestational trophoblastic diseases but were correctly diagnosed as ectopic pregnancies on MRI. Read More

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http://dx.doi.org/10.1155/2020/2417428DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315310PMC

Laparoscopic Excision of Cesarean Scar Pregnancy with Scar Revision.

J Minim Invasive Gynecol 2020 Jun 27. Epub 2020 Jun 27.

The Advanced Gynecologic Institute, Park Ridge, IL. Electronic address:

Objective: To demonstrate our technique for robotic assisted laparoscopic ectopic pregnancy excision and concomitant scar revision.

Design: We present a stepwise narrated demonstration of our primary laparoscopic technique.

Setting: Although cesarean scar pregnancy is rare, it leads to life-threatening complications and often emergent hysterectomy. Read More

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http://dx.doi.org/10.1016/j.jmig.2020.06.017DOI Listing

Tubal ectopic pregnancy with undetectable initial serum β-human chorionic gonadotropin level.

J Minim Invasive Gynecol 2020 Jun 26. Epub 2020 Jun 26.

The Ronald O. Perelman and Claudia Cohen Center for Reproductive Medicine, Weill Cornell Medicine, New York, New York.

We present a case of a tubal ectopic pregnancy (EP) in a patient with an initially undetectable serum β-human chorionic gonadotropin (β-hCG) level. A 33-year-old woman in a same-sex relationship underwent timed donor intrauterine insemination (IUI). Her serum β-hCG level was <5 mIU/mL fourteen days after the IUI. Read More

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http://dx.doi.org/10.1016/j.jmig.2020.06.015DOI Listing

Low body mass index is associated with ectopic pregnancy following assisted reproductive techniques: a retrospective study.

BJOG 2020 Jun 23. Epub 2020 Jun 23.

The Affiliated Chenggong Hospital of Xiamen University, Xiamen, Fujian, 361002, China.

Objective: To investigate the association between body mass index (BMI) and ectopic pregnancy (EP) following embryo transfer (ET).

Design: Retrospective cohort study.

Setting: University affiliated hospital. Read More

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http://dx.doi.org/10.1111/1471-0528.16378DOI Listing

The effect of storage time after vitrification on pregnancy and neonatal outcomes among 24 698 patients following the first embryo transfer cycles.

Hum Reprod 2020 Jun 23. Epub 2020 Jun 23.

Department of Assisted Reproduction, Shanghai Ninth people's hospital affiliated to JiaoTong University School of Medicine, Shanghai, China.

Study Question: To evaluate the impact of storage time after vitrification on embryo viability, pregnancy outcomes and neonatal outcomes.

Summary Answer: The prolonged storage time of vitrified embryos negatively affected pregnancy outcomes, including biochemical pregnancy rate, clinical pregnancy and live birth rate; but did not influence neonatal outcomes.

What Is Known Already: Although vitrification has been the fundamental tool of ART treatments in recent years, few studies have explored the influence of storage period after vitrification on embryonic and clinical outcomes. Read More

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http://dx.doi.org/10.1093/humrep/deaa136DOI Listing

Increased rate of ruptured ectopic pregnancy in the COVID-19 pandemic: an analysis from the North of Italy.

Ultrasound Obstet Gynecol 2020 Jun 23. Epub 2020 Jun 23.

Gynecology and Human Reproduction Physiopathology, Department of Obstetrics and Gynecology, DIMEC, Sant'Orsola Malpighi University Hospital, Bologna.

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http://dx.doi.org/10.1002/uog.22126DOI Listing

Cesarean scar pregnancy - case resports and literature review.

Pol Merkur Lekarski 2020 Jun;48(285):179-183

Department of Obstetrics and Gynecology, Pomeranian Medical University in Szczecin, Poland.

The current increase in the percentage of cesarean sections is accompanied by a significant growth in the incidence of cesarean scar pregnancies (CSP) located in the lower uterine segment, while the advancements in diagnostic ultrasound techniques have led to an increased number of CSP diagnoses. A misdiagnosed cesarean scar pregnancy, or one that is diagnosed too late, is a threat to the pregnant patient's life, and predisposes her to such complications as hemorrhage or uterine rupture, which often necessitate hysterectomy and therefore result in irreversible fertility loss. In this paper 4 cases of ectopic pregnancies located within the cesarean scar in women hospitalized at the university clinical center, within a short span of merely three months in 2018, are presented. Read More

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Treatment of tubal heterotopic pregnancy with viable intrauterine pregnancy: Analysis of 81 cases from one tertiary care center.

Eur J Obstet Gynecol Reprod Biol 2020 Jun 8;252:56-61. Epub 2020 Jun 8.

Department of Gynecology and Obstetrics, The First Affiliated Hospital, Sun Yat-Sen University, Guangdong, Guangzhou, 510080, PR China. Electronic address:

Objectives: The aim of our study was to analyze the treatment and pregnancy outcome of tubal heterotopic pregnancy (HP) patients with a viable intrauterine pregnancy (IUP) in our center.

Study Design: This was a retrospective analysis of 81 patients with tubal HP and a viable IUP. Patients were divided into either an expectant treatment group (29 patients) or a surgical treatment group (52 patients, 36 laparoscopy and 16 laparotomy). Read More

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http://dx.doi.org/10.1016/j.ejogrb.2020.06.005DOI Listing
June 2020
1.627 Impact Factor

An investigation of the time trends, risk factors, role of ultrasonic preoperative diagnosis of 79 ovarian pregnancy.

Arch Gynecol Obstet 2020 Jun 18. Epub 2020 Jun 18.

Department of Gynecology, Second Hospital of Hebei Medical University, No. 215, He Ping Road (West), Xin Hua District, Shijiazhuang, Hebei, China.

Background: Ovarian pregnancy (OP) is a rare form of ectopic pregnancy and is still a medical challenge. Therefore, more studies about the time trends, risk factors and diagnostic measurements are needed for the efficient treatment of OP.

Methods: The datum of OP patients who were treated at the Second Hospital of Hebei Medical University from 2003 to 2018 was collected and a retrospective cohort study was preformed between OP and tubal pregnancy. Read More

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http://dx.doi.org/10.1007/s00404-020-05648-6DOI Listing

Seven Years of Vitrified Blastocyst Transfers: Comparison of 3 Preparation Protocols at a Single ART Center.

Front Endocrinol (Lausanne) 2020 29;11:346. Epub 2020 May 29.

Yale University Fertility Center, New Haven, CT, USA.

Frozen-thawed embryo transfers (FET) have become a standard practice to increase cumulative pregnancy rates, however, the choice of the best preparation protocol remains a matter of debate. Retrospective analysis of clinical pregnancy (CPR) and live birth rate (LBR) of FET in natural cycles (NC-FET), modified natural cycles with hCG-triggered ovulation (mNC-FET), and hormonal artificial replacement (AR-FET). For natural cycles, patients were monitored by ultrasound to evaluate the dominant follicle and by urinary LH kits (NC-FET). Read More

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http://dx.doi.org/10.3389/fendo.2020.00346DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7272701PMC

Ectopic Cervical Pregnancy: Treatment Route.

Medicina (Kaunas) 2020 Jun 12;56(6). Epub 2020 Jun 12.

Institute for Maternal and Child Health IRCCS "Burlo Garofolo", 34100 Trieste, Italy.

Cervical pregnancy (CP) is a rare form of ectopic pregnancy (EP) in which the embryo implants and grows inside the endocervical canal. Early diagnosis is essential in order to allow conservative medical and surgical treatments. Although many treatment approaches are disponible, the most effective is still unclear. Read More

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http://dx.doi.org/10.3390/medicina56060293DOI Listing

The potential use of urinary hCG measurements in the management of pregnancies of unknown location.

Hum Fertil (Camb) 2020 Jun 16:1-8. Epub 2020 Jun 16.

Tommy's National Centre for Miscarriage Research, Queen Charlotte's & Chelsea Hospital, Imperial College, London, UK.

Multiple measurements of serum human chorionic gonadotropin (hCG) are used to predict the final pregnancy outcome for women with a pregnancy of unknown location (PUL) and monitor the management of ectopic pregnancy (EP). Urine-based testing would be more convenient and economical. This prospective cohort study involving 80 women assessed the degree of correlation between serum and urine hCG levels and whether urine hCG levels have the potential to impact clinical decision making in the management of women with a PUL. Read More

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http://dx.doi.org/10.1080/14647273.2020.1777590DOI Listing

Interstitial Pregnancy: Case Report of Atypical Ectopic Pregnancy.

Cureus 2020 May 13;12(5):e8081. Epub 2020 May 13.

Obstetrics and Gynecology, Santa Casa de Misericórdia Hospital, Sobral, BRA.

Interstitial or cornual implantation of the blastocyst is rare, accounting for 2% to 3% of ectopic pregnancies, being considered not viable. The important complications of interstitial pregnancy are uterine rupture and massive bleeding, which usually occur before 12 weeks of pregnancy. The authors report a case of a 36-year-old woman with complaints of transvaginal bleeding and abdominal pain associated with amenorrhea for seven weeks and positive beta-human chorionic gonadotropin (HCG). Read More

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http://dx.doi.org/10.7759/cureus.8081DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7292689PMC

Contralateral Fallopian Tube Dermoid Tumor: A Rare Finding in Chronic Tubal Ectopic Gestation.

Cureus 2020 May 12;12(5):e8065. Epub 2020 May 12.

Pathology and Laboratory Medicine, All India Institute of Medical Sciences Bhubaneswar, Bhubaneswar, IND.

Mature cystic teratoma is the most common benign tumor of the ovaries in women of reproductive age. Dermoid tumor in an ectopic or aberrant location is usually detected incidentally. The occurrence of a dermoid tumor in the fallopian tubes is extremely rare, with only approximately 75 cases being reported worldwide in the English language literature. Read More

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http://dx.doi.org/10.7759/cureus.8065DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7290119PMC

Suboptimal endometrial-embryonal synchronization is a risk factor for ectopic pregnancy in assisted reproduction techniques.

Reprod Biomed Online 2020 Apr 29. Epub 2020 Apr 29.

IVF Zentren Prof. Zech -Salzburg - Member of NEXTCLINICS, Innsbrucker Bundesstrasse 35, Salzburg 5020, Austria.

Research Question: What are the main risk factors associated with ectopic pregnancy and what is the true incidence of ectopic pregnancies in an IVF programme?

Design: Retrospective single-centre study of 12,429 blastocyst transfers (8182 fresh and 4247 frozen embryo transfers) conducted between January 2010 and December 2017. IVF outcome was analysed, and ectopic pregnancy risk evaluated according to patient's characteristics and assisted reproductive technology treatment factors.

Results: Of 5061 patients reporting a positive pregnancy test, 43 were diagnosed with ectopic pregnancy (0. Read More

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http://dx.doi.org/10.1016/j.rbmo.2020.03.018DOI Listing

A novel methotrexate protocol for the resolution of tubal ectopic pregnancies; Methodological issues on prognostic studies: Response.

Eur J Obstet Gynecol Reprod Biol 2020 Jun 3. Epub 2020 Jun 3.

Acute Gynaecology, Early Pregnancy and Advanced Endoscopy Surgery Unit, Nepean Hospital, Sydney Medical School Nepean, University of Sydney, Sydney, Australia.

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http://dx.doi.org/10.1016/j.ejogrb.2020.05.057DOI Listing

External validation of risk prediction model M4 in an Australian population: Rationalising the management of pregnancies of unknown location.

Aust N Z J Obstet Gynaecol 2020 Jun 15. Epub 2020 Jun 15.

Acute Gynaecology, Early Pregnancy and Advanced Endoscopic Surgery Unit, Nepean Hospital, Nepean Clinical School University of Sydney, Sydney, New South Wales, Australia.

Background: The prediction model M4 can successfully classify pregnancy of unknown location (PUL) into a low- or high-risk group in developing ectopic pregnancy. M4 was validated in UK centres but in very few other countries outside UK.

Aim: To validate the M4 model's ability to correctly classify PULs in a cohort of Australian women. Read More

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http://dx.doi.org/10.1111/ajo.13201DOI Listing
June 2020
1.620 Impact Factor

In silico vaccine design against infection.

Netw Model Anal Health Inform Bioinform 2020 10;9(1):39. Epub 2020 Jun 10.

Biodiscovery Group for Life Sciences, Bangalore, India.

a gram-negative bacterium known to infect the genital sites mainly columnar epithelial cells of the cervix, urethra and rectum in women and causes acute epididymitis, urinary tract inflammation and DNA damage to the sperms in men, hence considered to be one of the major sexually transmitted infections. The infection is asymptomatic in many people and remains untreated leading to serious health complications, including pelvic inflammatory disease, ectopic pregnancy and infertility. The current treatment options include antibiotics, but the pathogen has gained resistance against many antibiotics. Read More

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http://dx.doi.org/10.1007/s13721-020-00243-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7283423PMC

Pre-pregnancy, obstetric and delivery status in women with neuromyelitis optica spectrum disorder.

Mult Scler Relat Disord 2020 Jun 2;44:102252. Epub 2020 Jun 2.

Department of Neurology, Slagelse Hospital, Institute of Regional Health Research, Denmark; Department of Neurobiology, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark. Electronic address:

Background: Neuromyelitis optica spectrum disorder (NMOSD) is a potentially disabling disease which affects predominantly women of reproductive age.

Objectives: To evaluate the pre-pregnancy condition and to investigate the prevalence of obstetrical and neonatal complaints in NMOSD.

Methods: An observational retrospective study of 37 NMOSD patients positive for aquaporin-4-immunoglobulin-IgG. Read More

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http://dx.doi.org/10.1016/j.msard.2020.102252DOI Listing

Abdominal pregnancy during the COVID-19 pandemic.

Int J Gynaecol Obstet 2020 Jun 10. Epub 2020 Jun 10.

Department of Biomedical Sciences and Human Oncology, Gynecologic and Obstetrics Clinic, Bari, Italy.

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http://dx.doi.org/10.1002/ijgo.13271DOI Listing

A population-specific optimized GeneXpert pooling algorithm for and to reduce cost of molecular STI screening in resource-limited settings.

J Clin Microbiol 2020 Jun 10. Epub 2020 Jun 10.

Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA 30322.

The sexually transmitted infections (STIs) chlamydia (CT) and gonorrhea (NG) are often asymptomatic in women and undetected by syndromic management, leading to complications such as pelvic inflammatory disease, infertility, and ectopic pregnancy. Molecular testing, such as the GeneXpert CT/NG assay, is highly sensitive, but cost restraints preclude implementation of these technologies in resource-limited settings. Pooled testing is one strategy to reduce the cost-per-sample, but the extent of savings depends on disease prevalence. Read More

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http://dx.doi.org/10.1128/JCM.00176-20DOI Listing

The Largest Tubal Pregnancy: 14th Week.

Case Rep Obstet Gynecol 2020 20;2020:4728730. Epub 2020 May 20.

Hamad Medical Corporation, Qatar.

Subsequent development and implantation of embryo outside the uterine lining are defined as an ectopic pregnancy. Ectopic pregnancies have a wide range of presentations, for example, acute hemoperitoneum to chronic ectopic pregnancy. The case presented is an unusual case of ectopic pregnancy with large hematosalpinx with classic symptoms. Read More

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http://dx.doi.org/10.1155/2020/4728730DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7260646PMC

Cesarean Scar Ectopic Pregnancy: The Lurking Danger in Post Cesarean Failed Medical Abortion.

J Family Reprod Health 2019 Dec;13(4):223-227

Department of Obstetrics and Gynecology, AIIMS Patna, Patna, India.

Cesarean scar pregnancy (CSP) is a potentially life threatening ectopic pregnancy where a missed diagnosis is commoner than an accurate diagnosis. Incidence of Ectopic pregnancy is 1 - 2 % and cesarean scar ectopic occurs in about (0.05%) 1 in 2000 of all pregnancies. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7264869PMC
December 2019

, and among women with genitourinary infection and pregnancy-related complications in Tehran: A cross-sectional study.

Int J STD AIDS 2020 Jun 10:956462420922462. Epub 2020 Jun 10.

Faculty of Medicine, Centre for Clinical Research, The University of Queensland, Herston, Queensland, Australia.

The present study investigates the prevalence of (CT), (NG), and (TV) among women with genitourinary infection and pregnancy-related complications in Tehran. It also evaluates the demographic information, symptoms, and sequelae. Endocervical samples were obtained over a period of eight months from 360 women including 180 symptomatic patients and 180 patients with pregnancy-related complications and infertility. Read More

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http://dx.doi.org/10.1177/0956462420922462DOI Listing

Social prevalence of knowledge about ectopic pregnancy - tip of the 'health inequalities' iceberg?

J Obstet Gynaecol 2020 Jun 9:1-6. Epub 2020 Jun 9.

Whipps Cross University Hospital, Barts Health NHS Trust, London, UK.

We aimed to assess the social and demographic factors determining the level of awareness of the signs and symptoms of ectopic pregnancy (EP) in an East London female population and determine if awareness was related to adverse outcomes. This was a prospective, observational study using a structured questionnaire to assess awareness of EP. A retrospective analysis of a database of EP patients was used to assess the association between adverse clinical outcomes and knowledge about EP. Read More

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http://dx.doi.org/10.1080/01443615.2020.1741521DOI Listing
June 2020
0.604 Impact Factor

The Utility of Myometrial and Cervical Ultrasound Shear Wave Elastography in the Diagnosis of Ectopic Pregnancy.

Ultrasound Med Biol 2020 Jun 4. Epub 2020 Jun 4.

Manisa Celal Bayar University, Department of Obstetrics and Gynecology, Perinatology Division, Manisa, Turkey.

We aimed to assess the potential utility of myometrial and cervical elasticity measurement in the diagnosis of ectopic pregnancy (EP), which could facilitate the diagnosis process. Myometrial and cervical elasticity values were measured in women with EP, women with early intrauterine pregnancy (IP) and non-pregnant women. Transabdominal point shear wave elastography (pSWE) was used for elasticity measurements. Read More

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http://dx.doi.org/10.1016/j.ultrasmedbio.2020.04.035DOI Listing

Ultrasound-guided intrasacular injection of methotrexate in the management of ectopic pregnancies with embryo. A 12 year experience report in a tertiary hospital.

Eur J Obstet Gynecol Reprod Biol 2020 May 30;251:180-183. Epub 2020 May 30.

Maternal-Fetal Medicine Unit, Department of Obstetrics, Miguel Servet Maternal University Hospital, Paseo Isabel la Católica, 1-3, 50009 Zaragoza, Spain. Electronic address:

Objective: To evaluate the efficacy and safety of combined-therapy with ultrasound guided intrasacular injection of 50 mg of methotrexate (MTX) and a 50 mg/m dose of systemic MTX in uncomplicated ectopic pregnancies with ultrasonographic evidence of embryonic structures in the gestational sac.

Study Design: We designed a retrospective study including 60 patients to assess the efficacy of combined MTX treatment and to determine which clinical or ultrasonographic variables could be associated with successful medical treatment. Failed medical treatment was defined when surgery was needed. Read More

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http://dx.doi.org/10.1016/j.ejogrb.2020.05.067DOI Listing

Case report of persistent elevation of βhCG in a nonpregnant woman: A diagnostic puzzle.

J Obstet Gynaecol Res 2020 Jun 4. Epub 2020 Jun 4.

The Obstetrics and Gynaecology Clinic Narodni Front, Belgrade, Serbia.

Detectable serum levels of beta subunit of human chorionic gonadotropin (βhCG) in nonpregnant, perimenopausal women bring confusion in both clinician and patient and could lead to unnecessary diagnostic and therapeutic procedures. A 45-year-old woman with the continuous elevation of βhCG underwent hysteroscopy, two laparoscopic surgeries, two explorative uterine cavity curettages and three cycles of cytostatic therapy. No ultrasonographic, macroscopic or histological signs of pregnancy, both uterine and ectopic or gestational trophoblastic disease were found. Read More

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http://dx.doi.org/10.1111/jog.14312DOI Listing

Pathophysiologic mechanisms by which adenomyosis predisposes to postpartum haemorrhage and other obstetric complications.

Med Hypotheses 2020 May 13;143:109833. Epub 2020 May 13.

Department of Molecular and Developmental Medicine, University of Siena, Italy.

Adenomyosis is characterized by the presence of ectopic endometrium within the myometrium. This features lead to structural changes in the surrounding myometrium and endometrium resulting also in functional changes. Alterations in the myometrium are suspected to lead to defective remodeling of spiral arteries during the early stages of decidualization resulting in altered vascular resistance and defective placentation. Read More

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http://dx.doi.org/10.1016/j.mehy.2020.109833DOI Listing

Right-sided ovarian ectopic pregnancy with Jaydess in situ.

Ginekol Pol 2020 ;91(5):294

Fetal Medicine and Gynecology Department, Medical University of Lodz, Poland.

The estimated prevalence of the ectopic pregnancy (EP) is 1-2% of all pregnancies. Ovarian pregnancy is a rare finding with an incidence rate of 0.15% of all pregnancies and 1-3% of ectopic gestations. Read More

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http://dx.doi.org/10.5603/GP.2020.0059DOI Listing
January 2020

Ruptured Right Broad Ligament Ectopic Pregnancy in a Patient With Prior Right Salpingo-Oophorectomy: A Case Report.

Cureus 2020 May 25;12(5):e8276. Epub 2020 May 25.

Family Medicine, Wellspan Good Samaritan Hospital, Lebanon, USA.

Ectopic pregnancy can be a life-threatening cause of acute abdomen. Broad ligament pregnancy accounts for 1% of ectopic abdominal pregnancies and complications can be calamitous. This case report highlights a 27-year-old G2P0010 female who presented with amenorrhea and acute right lower quadrant and pelvic pain. Read More

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http://dx.doi.org/10.7759/cureus.8276DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7263000PMC

Ruptured ectopic pregnancy after hysterectomy with copper intrauterine device in place: A case report.

Case Rep Womens Health 2020 Jul 20;27:e00223. Epub 2020 May 20.

Department of Obstetrics and Gynecology, Albany Medical Center, 391 Myrtle Avenue, 2 floor, MC-74, Albany, NY 12208, USA.

Introduction: Ectopic pregnancy after hysterectomy is a rare event, with 72 cases being reported since 1895. Concomitant use of reliable contraception at the time of hysterectomy makes pregnancy extremely unlikely, but, as this case illustrates, does not completely rule out the possibility of post-hysterectomy ectopic pregnancy.

Case: A 30-year-old woman experienced a ruptured fallopian tube ectopic pregnancy four weeks after a laparoscopic-assisted vaginal hysterectomy and left salpingo-oophorectomy. Read More

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http://dx.doi.org/10.1016/j.crwh.2020.e00223DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7256286PMC

Benzodiazepine use before conception and risk of ectopic pregnancy.

Hum Reprod 2020 Jun 3. Epub 2020 Jun 3.

Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA.

Study Question: Are women who fill a benzodiazepine prescription before conception at increased risk of ectopic pregnancy?

Summary Answer: Risk of ectopic pregnancy is 50% higher among women who fill a benzodiazepine prescription before conception.

What Is Known Already: Benzodiazepine use in pregnancy increases the risk of miscarriage, adverse birth outcomes and adverse child development outcomes.

Study Design, Size, Duration: Using data from US commercial insurance claims, we performed a cohort study of 1 691 366 pregnancies between 1 November 2008 and 30 September 2015. Read More

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http://dx.doi.org/10.1093/humrep/deaa082DOI Listing

Upregulation of elafin expression in the fallopian tube of ectopic tubal pregnancies compared to the normal tubes.

J Reprod Immunol 2020 May 21;141:103136. Epub 2020 May 21.

Department of Histology, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran; Infectious Diseases and Tropical Medicine Research Center, Resistant Tuberculosis Institute, Zahedan University of Medical Sciences, Zahedan, Iran. Electronic address:

Background: Ectopic pregnancy is one of the most important causes of maternal deaths and fallopian tubes are the location of 95% of ectopic pregnancies. Elafin is a natural antimicrobial molecule that plays an important role as an anti-inflammatory agent in mucosal surfaces and has been found in the female reproductive tract.

Objectives: The aim of this study was to investigate elafin expression, in the fallopian tube mucosa of ectopic pregnancies compared to the normal tubes using immunohistochemistry (IHC) techniques and quantitative reverse transcription (qRT)-PCR. Read More

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http://dx.doi.org/10.1016/j.jri.2020.103136DOI Listing
May 2020
2.815 Impact Factor

The live birth and neonatal outcomes in the subsequent pregnancy among patients with adverse pregnancy outcomes in first frozen embryo transfer cycles.

Arch Gynecol Obstet 2020 May 28. Epub 2020 May 28.

Department of Assisted Reproduction, Shanghai Ninth People's Hospital affiliated to JiaoTong University School of Medicine, Zhizaoju Road No. 639, Shanghai, China.

Purpose: To explore whether the adverse pregnancy outcomes in first frozen embryo transfer (FET) cycles affect live birth and neonatal outcomes in the subsequent pregnancy?

Methods: This was a retrospective study. Women with a history of adverse pregnancy outcomes in first FET cycles started their subsequent embryo transfer cycles. The adverse pregnancy outcomes included biochemical pregnancy, ectopic pregnancy, and first-trimester pregnancy loss. Read More

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http://dx.doi.org/10.1007/s00404-020-05608-0DOI Listing

Magnetic resonance imaging of the female pelvis after Cesarean section: a pictorial review.

Insights Imaging 2020 May 27;11(1):75. Epub 2020 May 27.

Department of Diagnostic Imaging, Institute of Mother and Child, Kasprzaka 17a, 01-211, Warsaw, Poland.

The rate of Cesarean sections (C-sections) in Poland increased from 21.7% in 2001 to 43.85% in 2017 even though the Polish Society of Gynecologists and Obstetricians highlights the negative consequences of C-section for both mother and child and recommends to make every possible effort to reduce its percentage, following the World Health Organization recommendations. Read More

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http://dx.doi.org/10.1186/s13244-020-00876-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253593PMC

The Effect of Different Treatment Regimens and Multiple Risk Factors on Adverse Pregnancy Outcomes among Syphilis-Seropositive Women in Guangzhou: A Retrospective Cohort Study.

Biomed Res Int 2020 1;2020:7626274. Epub 2020 May 1.

Department of Child Health, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, Guangdong, China.

Background: To eliminate mother-to-child transmission of syphilis, the Chinese government recommends a treatment regimen that slightly differs from the World Health Organization- (WHO-) recommended treatment. However, little is known about their difference in efficacy. This study is aimed at comparing the effect of China-recommended and WHO-recommend treatment regimens on adverse pregnancy outcomes (APOs) and at examining associated risk factors of APOs among syphilis-seropositive women. Read More

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http://dx.doi.org/10.1155/2020/7626274DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7222490PMC

Shikonin suppresses trophoblast cell growth via regulation of GLI1, and p62 mediated caspase 8 activation.

Reprod Toxicol 2020 Aug 24;95:104-112. Epub 2020 May 24.

The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, 510405, China. Electronic address:

Unruptured ectopic pregnancy (UEP) is a common cause of morbidity and, occasionally, of mortality in women of reproductive age. Pharmacological intervention is a common therapeutic approach for early-stage UEP. Herein, we investigated the cytotoxic effect and novel mechanism of shikonin, a natural naphthoquinone pigment purified from Lithospermum erythrorhizon, in human trophoblast cells. Read More

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http://dx.doi.org/10.1016/j.reprotox.2020.05.011DOI Listing

Ectopic Pregnancy During Coronavirus Disease 2019 (COVID-19): To Operate, or Not to Operate.

Obstet Gynecol 2020 May 27. Epub 2020 May 27.

University of South Dakota Sanford School of Medicine, Sanford Health Fertility and Reproductive Medicine, Sioux Falls, South Dakota; and the Department of Obstetrics and Gynecology, Methodist Health System, Dallas, Texas.

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http://dx.doi.org/10.1097/AOG.0000000000003995DOI Listing

Live Twin Ectopic Pregnancy.

J Emerg Med 2020 May 22. Epub 2020 May 22.

Department of Emergency Medicine, The Mount Sinai Hospital, New York, New York.

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http://dx.doi.org/10.1016/j.jemermed.2020.04.033DOI Listing

Anesthetic efficacy of propofol combined butorphanol in laparoscopic surgery for ectopic pregnancy: A protocol of systematic review and meta-analysis.

Medicine (Baltimore) 2020 May;99(20):e20289

Department of Anesthesiology, Yan'an People's Hospital, Yan'an, China.

Background: Recent studies have suggested that propofol combined butorphanol (PB) has anesthetic effect in laparoscopic surgery (LS) for ectopic pregnancy (EP). But investigations of its potential effects are inconsistent. We will explore the current literature examining PB in LS for EP. Read More

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http://dx.doi.org/10.1097/MD.0000000000020289DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253537PMC

Ectopic pregnancies in caesarean section scars: 5 years experience.

Clin Imaging 2020 May 3;66:26-34. Epub 2020 May 3.

Undergraduate, Faculty of Medicine, Kasr Alainy, Cairo University, Egypt.

Purpose: The aim of the study is to evaluate our 5 years experience in diagnosis and treatment of ectopic pregnancy developing in a Caesarean section scar.

Subjects & Methods: The study included twenty-one women, diagnosed with a Caesarean scar ectopic pregnancy (CSEP) in the first trimester, which was confirmed by ultrasound and treated in our hospital during 5 years between 2012 and 2016. The clinical presentations, imaging findings, and treatment outcomes of all these pregnancies were recorded. Read More

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http://dx.doi.org/10.1016/j.clinimag.2020.04.037DOI Listing

Antidepressant Use around Conception, Prepregnancy Depression, and Risk of Ectopic Pregnancy.

Can J Psychiatry 2020 May 21:706743720927829. Epub 2020 May 21.

Department of Pediatrics, Stanford University School of Medicine, CA, USA.

Objective: To compare the risk of ectopic pregnancy among women with and women without antidepressant prescriptions around conception and examine whether this risk differs by prepregnancy depression status.

Methods: We conducted a cohort study of all pregnancies between November 1, 2008, and September 30, 2015, identified in the nationwide (American) IBM® MarketScan® Databases. At least one day's supply of antidepressants in the 3 weeks after a woman's last menstrual period defined active antidepressant use around conception. Read More

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http://dx.doi.org/10.1177/0706743720927829DOI Listing