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Gynecol Oncol Rep 2021 Aug 30;37:100798. Epub 2021 May 30.

Helen Schneider Hospital for Women, Rabin Medical Center, Petah Tikva, Israel.

•Ectopic molar pregnancies are a rare gynecological occurrence.•Gestational trophoblastic neoplasia (GTN) can arise following an ectopic molar pregnancy.•Histopathology should be sought and hCG levels should be monitored after surgical treatment of ectopic pregnancies. Read More

Wiad Lek 2021 ;74(4):940-947

ISIDA-IVF MEDICAL CENTER LLC, KYIV, UKRAINE.

Objective: The aim: To carry out a statistical analysis of physical and reproductive health characteristics in women after ineffective reattempts of using assisted reproductive technologies and identify significant medical and social factors contributing to the development of chronic endometritis.

Patients And Methods: Materials and methods: We carried out a statistical analysis involving 177 outpatient medical records: group 1 includes 127 women aged under 45 with two or more ineffective attempts of in vitro fertilization; group 2 comprised 50 healthy women without reproductive disorders. The complete physical exam included past history, clinical and gynecologic examination, lab techniques and medical imaging according to outpatient medical records obtained during the follow-up care in Isida-IVF Medical Center LLC. Read More

J Obstet Gynaecol 2021 Jun 22:1-8. Epub 2021 Jun 22.

Department of Obstetrics and Gynecology, Faculty of Medicine, Menoufia University, Shibin Elkom, Egypt.

The purpose of this study was to compare the short-term operative outcomes of three different surgical techniques for uterine incision closure during caesarean section (CS). This trial enrolled 120 patients scheduled for primary caesarean delivery. Patients were randomised into either classical double-layer uterine closure, purse-string double-layer uterine closure (Turan), or our new approach of uterine closure (double layer step up-step down technique). Read More

J Emerg Med 2021 Jun 17. Epub 2021 Jun 17.

Department of Emergency Medicine, SUNY Downstate Medical Center, Brooklyn, New York; Department of Emergency Medicine, Kings County Hospital Center, Brooklyn, New York.

Background Bilateral ectopic pregnancies (EPs) occur in 1 of 200,000 pregnancies. Evidence suggests that endometriosis is an independent risk factor for unilateral EPs. However, the link between endometriosis and bilateral EPs has not been established. Read More

Am J Emerg Med 2021 Jun 9;49:226-232. Epub 2021 Jun 9.

Emergency Department, Boston Medical Center, Boston University School of Medicine, 1 Boston Medical Center Place, Boston, MA 02118, United States of America.

Background: Point-of-care ultrasound (POCUS) is useful in the evaluation of early pregnancy by confirming intrauterine pregnancy and recognizing hemorrhage from ectopic pregnancy. We sought to determine whether transabdominal POCUS by itself or in conjunction with consultative radiology ultrasound (RADUS), reduces Emergency Department (ED) treatment time for patients with ectopic pregnancy requiring operative care, when compared to RADUS alone. A secondary objective was to determine whether the incorporation of POCUS reduces time to operative care for patients with ruptured ectopic pregnancy specifically, when compared to RADUS alone. Read More

Case Rep Womens Health 2021 Jul 31;31:e00331. Epub 2021 May 31.

Royal Prince Alfred Hospital, Sydney, NSW, Australia.

Background: Heterotopic pregnancy is a rare form of pregnancy that involves implantation of simultaneous pregnancies at two sites. They are normally identified in early gestation when patients become symptomatic with vaginal bleeding or abdominal pain.

Case Presentation: A 35-year-old woman (para 0, gravida 2) presented to the emergency department in haemorrhagic shock at 19 weeks and 5 days of gestation. Read More

Int J Surg Case Rep 2021 Jun 10;84:106109. Epub 2021 Jun 10.

Department of General & Minimally Invasive Surgery, Atal Bihari Vajpayee Institute of Medical Sciences & Dr Ram Manohar Lohia Hospital, New Delhi, India.

Introduction: Numerous complications can occur after a surgery, but gossypiboma is undoubtedly the most unwanted and undesirable complication of a procedure for any surgeon with legal implications. Once suspected, the minimally invasive surgical approach should be considered for its management.

Presentation Of Case: An adult PLE female presented to the surgery OPD with a painless abdominal mass which progressively increased in size in the past 4 months. Read More

Cureus 2021 May 13;13(5):e15002. Epub 2021 May 13.

Faculty of Medicine, Autonomous University of the State of Mexico, Toluca, MEX.

Background Nitazoxanide shows adequate activity against coronavirus. The aim of this study was to describe the behavior of coronavirus disease 2019 (COVID-19) in pregnant women treated with nitazoxanide. Methodology This cross-sectional study included the files of COVID-19 positive pregnant women treated with nitazoxanide 500 mg every 6 hours, levofloxacin every 12 hours, and clarithromycin 500 mg every 12 hours. Read More

Fertil Steril 2021 Jun 8. Epub 2021 Jun 8.

Reproductive Biology Associates, Atlanta, Georgia.

Objective: To illustrate a novel surgical management technique for interstitial ectopic pregnancies (IP).

Design: Video description of the case, demonstration of the surgical technique, reevaluation at the 6-week postoperative follow-up, and review of the advantages of this surgical technique for IP.

Setting: Tertiary referral center. Read More

Curr Obstet Gynecol Rep 2020 Mar 30;9(1):27-35. Epub 2020 Jan 30.

Department of Epidemiology, Harvard T.H. Chan School of Public Health.

Purpose Of Review: There is increasing interest in the long-term health and comorbid conditions associated with endometriosis for both women and neonates. The purpose of this review was to synthesize and discuss the current state of the literature investigating endometriosis and risk of adverse pregnancy outcomes.

Recent Findings: Methodologic considerations for studying endometriosis and adverse pregnancy outcomes include complexities regarding the comparison population, endometriosis definition, sample size, residual confounding, and interactions. Read More

J Gynecol Obstet Hum Reprod 2021 Jun 6:102180. Epub 2021 Jun 6.

Northwestern University Feinberg School of Medicine, Department of Obstetrics & Gynecology; John H. Stroger Hospital, Department of Obstetrics & Gynecology, Division of Family Planning. Electronic address:

Introduction: Adherence to follow-up is an important consideration when treating non-emergent ectopic pregnancy. Our aim was to evaluate the management of ectopic pregnancy among patients in a public hospital system and to identify factors related to adherence of medical management in this population.

Material And Methods: A retrospective review to evaluate the management of ectopic pregnancy among women in a public hospital system, including all women undergoing treatment for ectopic pregnancy from 2012 to 2017. Read More

J Minim Invasive Gynecol 2021 Jun 5. Epub 2021 Jun 5.

From the Department of Gynaecology, The Royal Women's Hospital Parkville, Victoria, Australia.

This case focused on a 39-year-old female with a significant history of secondary, infertility recurrent miscarriage and recurrent suspected left tubal ectopic pregnancy which was initially managed repeatedly and conservatively with methotrexate. Eventual laparoscopic assessment and left salpingectomy instead confirmed a left, tubal fibroid. Therefore, previous episodes of suspected ectopic pregnancy were likely, recurrent miscarriage. Read More

Case Rep Womens Health 2021 Jul 15;31:e00327. Epub 2021 May 15.

West Virginia University School of Medicine, United States of America.

Background: Extrauterine ectopic pregnancy is a rare form of ectopic pregnancy, accounting for roughly 1:10,000-30,000 of all pregnancies. Primary omental pregnancy is the least common form of abdominal ectopic pregnancies, making it extremely rare. Typical presentation includes pelvic pain, secondary amenorrhea, with or without vaginal bleeding. Read More

Radiol Case Rep 2021 Jul 21;16(7):1851-1853. Epub 2021 May 21.

Department of Radiology and Imaging Sciences, University of Utah, 30 North 1900 East #1A71, Salt Lake City, UT 84132.

An ectopic pregnancy carries the potential for disastrous maternal complications. Early first trimester pelvic ultrasound examinations are frequently obtained in cases of pelvic pain and vaginal bleeding to assess for such diagnoses. The "bagel sign" and the "blob sign" described two sonographic appearances of tubal ectopic pregnancy with positive predictive values of > 95%. Read More

Exp Ther Med 2021 Aug 26;22(2):801. Epub 2021 May 26.

Department of Obstetrics, Affiliated Hospital of Jining Medical University, Jining, Shandong 272000, P.R. China.

The present study was designed to analyze the expression of pregnancy-associated plasma protein-A (PAPP-A) in the serum of patients with ectopic pregnancy (EP) and related factors inducing this condition. Seventy-five patients with EP admitted to the Affiliated Hospital of Jining Medical University from January 2018 to February 2019 were selected as the research group, and another 59 healthy pregnant women of the corresponding age, gravidity and gestational week were enrolled in the control group. ELISA was employed to detect the serum expression levels of PAPP-A and inflammatory factors such as interleukin-8 (IL-8) and tumor necrosis factor-α (TNF-α). Read More

Sex Transm Dis 2021 Jun 5. Epub 2021 Jun 5.

Centers for Disease Control and Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, Division of STD Prevention, Atlanta, GA Michigan Department of Health and Human Services, Detroit, MI.

Abstract: Since 2010, reported chlamydia and gonorrhea rates decreased among Black women aged 15-19 years and were stable for Black women 20-24 in the United States. Rates increased for older Black women 25-39 and all White women. The Black:White rate ratio decreased across age groups. Read More

J Gynecol Obstet Hum Reprod 2021 Jun 2;50(9):102175. Epub 2021 Jun 2.

Department of Obstetrics and Gynecology, Bezmialem Vakıf University, Istanbul, Turkey.

Objective: The aim of this study was to investigate the thiol/disulfide homeostasis in tubal ectopic pregnancies in terms of early diagnosis of the disease.

Design: A prospective case-control study was carried out between June 2017-February 2018 in the Gynaecology Department of Umraniye Medical and Research Hospital.

Materials And Methods: A total of 42 women with ectopic pregnancy were compared with 44 healthy women who have intrauterine first trimester pregnancies. Read More

Reprod Biol Endocrinol 2021 Jun 4;19(1):84. Epub 2021 Jun 4.

Department of Obstetrics and Gynecology, Akita University Graduate School of Medicine, 010-8543, Akita, Japan.

Background: Uterine adenomyosis is a benign disease, common among women in their 40 and 50 s, characterised by ectopic endometrial tissue in the uterine myometrial layer. Adenomyosis causes infertility and has a negative effect on the outcomes of in vitro fertilisation (IVF)/intracytoplasmic sperm injection (ICSI) embryo transfer (ET) cycles. It has also been reported to have different characteristics depending on the adenomyotic lesion localisation. Read More

Clin Case Rep 2021 May 24;9(5):e04261. Epub 2021 May 24.

Department of Gynecology and Obstetrics University Hospitals Schleswig-Holstein Kiel Germany.

Unicornuate uterus with pregnancy in the noncommunicating rudimentary horn is extremely rare. Diagnosis requires awareness, high suspicion index, 3D ultrasound, and MRI. If missed, it can be catastrophic. Read More

S Afr Fam Pract (2004) 2021 May 27;63(1):e1-e5. Epub 2021 May 27.

Department of Anaesthetics, Critical Care and Pain Management, University of KwaZulu-Natal, Durban.

In South Africa, deaths as a result of ectopic pregnancies are increasing despite the overall improvements in maternal mortality. These deaths occur predominantly in district hospitals, with the final cause of death being hypovolaemic shock in almost all cases. In most cases, no anaesthesia was attempted despite the district hospitals having the clinical skills, equipment and infrastructure to provide a caesarean delivery service. Read More

Turk J Obstet Gynecol 2021 06;18(2):85-91

Başkent University Faculty of Medicine, Adana Dr. Turgut Noyan Research and Application Center, Clinic of Obstetrics and Gynecology, Adana, Turkey

Objective: To investigate the success and complications of medical and surgical modalities used in the treatment of cesarean scar pregnancies.

Materials And Methods: Medical and surgical approaches that have been used to treat cesarean scar pregnancies were evaluated retrospectively, Local, systemic, and combined methotrexate treatments were grouped as the medical approach, and dilatation and evacuation, hysteroscopic resection, laparoscopic and laparotomic approaches were grouped as the surgical approach. Fifty-three patients were diagnosed as having cesarean scar pregnancy during the study period, 48 of whom were included in the final analysis. Read More

Mult Scler Relat Disord 2021 May 19;53:103021. Epub 2021 May 19.

UConn Health Comprehensive Multiple Sclerosis Center, Department of Neurology, University of Connecticut School of Medicine, Farmington, CT 06030, United States; Division of Multiple Sclerosis and Translational Neuroimmunology, Department of Neurology, University of Connecticut School of Medicine, Farmington, CT 06030, United States. Electronic address:

Background: Ocrelizumab (OCR) is a humanized monoclonal antibody directed against CD20 positive B-lymphocytes. It was approved for use in 2017 by the U.S. Read More

Medicina (Kaunas) 2021 May 12;57(5). Epub 2021 May 12.

Department of Obstetrics and Gynecology, Carol Davila University of Medicine and Pharmacy, 020021 Bucharest, Romania.

Heterotopic pregnancy is the condition where both intrauterine and ectopic pregnancy are present. It rarely occurs after natural conception, but is more common with assisted reproductive techniques, when more than one embryo is transferred. Quadruplet heterotopic pregnancy is exceedingly rare. Read More

Reprod Biol Endocrinol 2021 Jun 1;19(1):79. Epub 2021 Jun 1.

Department of Obstetrics and Gynecology, Buergerhospital - Dr. Senckenbergische Stiftung, Nibelungenallee 37-41, D-60318, Frankfurt am Main, Hessen, Germany.

Purpose: The aim of this study was to investigate characteristics associated with ectopic pregnancy (EP) that could be utilized for predicting morbidity or mortality.

Methods: This was a retrospective analysis of pregnancy-related records from a tertiary center over a period of ten years. Data on age, gravidity, parity, EP risk, amenorrhea duration, abdominal pain presence and location, β-human chorionic gonadotropin (β-HCG) level, ultrasound findings, therapeutic intervention, exact EP implantation site and length of hospital stay (LOS) were obtained from the database. Read More

J Dermatolog Treat 2021 Jun 16:1-6. Epub 2021 Jun 16.

Department of Dermatology, Soonchunhyang University Hospital, Seoul, Korea.

Background: Doxycycline is one of the most prescribed antibiotics by dermatologists. However, the concern regarding adverse events of doxycyline has been rising.

Objective: To detect the adverse events of doxycycline using the Korea Adverse Events Reporting System (KAERS) database from January 2014 to December 2018 through a data mining method. Read More

Case Rep Pediatr 2021 17;2021:5583840. Epub 2021 May 17.

Bai Jerbai Wadia Hospital for Children, Parel, Mumbai, India.

. Methemoglobinemia is a potentially life-threatening condition which presents with cyanosis and characteristic "chocolate-coloured blood." Although a co-oximetry would give a prompt diagnosis, there have been multiple reports of misdiagnosing this treatable condition-from being diagnosed as sepsis to asthma and even being operated for "ruptured ectopic pregnancy. Read More

Case Rep Obstet Gynecol 2021 14;2021:6670763. Epub 2021 May 14.

Department of Obstetrics and Gynaecology, King Hamad University Hospital, Al Sayh, Bahrain.

Nontubal ectopic pregnancies, especially ovarian ones, are rare. Here, we report a case of spontaneous bilateral ovarian pregnancy in a 23-year-old nulliparous lady who presented with a three-day history of abdominal pain localized to the right iliac fossa. Laboratory investigations and pelvic US and transvaginal US findings were suggestive of a right ovarian ectopic pregnancy and left ovarian cyst. Read More

J Surg Case Rep 2021 May 27;2021(5):rjab216. Epub 2021 May 27.

Departamento de Toxicología, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional (CINVESTAV-IPN), México City, México.

If methotrexate (MTX) fails to resolve cervical ectopic pregnancies (CEP), the remaining surgical options result in the potential loss of the patient's fertility. Therefore, we examined if the embryo reduction technique can resolve the CEP without any complications while conserving the patient's fertility. We report three cases in which CEP didn't respond to MTX but was successfully solved by embryo reduction. Read More

Gynecol Obstet Fertil Senol 2021 May 27. Epub 2021 May 27.

Service de Gynécologie Obstétrique et Médecine de la Reproduction, Centre Hospitalier Intercommunal de Créteil, 40, avenue de Verdun, 94000 Créteil, France; Université de Médecine Paris Est Créteil (UPEC), Paris XII, France.

Reprod Health 2021 May 28;18(1):109. Epub 2021 May 28.

School of Medicine, The University of Jordan, Amman, Jordan.

Background: Pelvic inflammatory disease (PID) is the inflammation of the adnexa of the uterus, that mainly manifests in a subclinical/chronic context and goes largely underreported. However, it poses a major threat to women's health, as it is responsible for infertility and ectopic pregnancies, as well as chronic pelvic pain. Previous studies in Jordan have not reported PID, attributed mainly to the social structure of the country which largely represents a sexually conservative population. Read More