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Int J Gynaecol Obstet 2022 Jun 24. Epub 2022 Jun 24.

Department of Obstetrics and Gynecology, Cholet Hospital, 49300, Cholet, France.

Objective: To analyze outcomes and postoperative complications in patients undergoing robot-assisted isthmocele repair.

Method: This retrospective cohort study included 33 patients who had robot-assisted laparoscopic surgical management of an isthmocele between September 2013 and August 2020 in two French university hospitals. All charts were reviewed to identify patient characteristics, pre- and postoperative anatomical findings, complications, and postoperative fertility and symptoms. Read More

Medicina (Kaunas) 2022 May 30;58(6). Epub 2022 May 30.

Department of Obstetrics & Gynaecology, University Hospital of Larisa, Mezourlo, 41334 Larisa, Greece.

: Caesarean scar pregnancy (CSP) refers to placental implantation on or in the scar of a previous caesarean section and represents a potentially life-threatening condition. CSP is considered a diagnostic challenge in obstetrics, with the diagnosis relying mainly on transvaginal ultrasound (TVS) and the management depending upon case presentation and available healthcare infrastructures. : We present a case of 34-year-old G3P2 with a history of two-previous caesarean sections referred to the outpatient gynaecology clinic of our Department at the 7th week (7/40) of gestation with abnormal early pregnancy TVS findings, illustrating the gestational sac attached to the caesarean scar and a foetal pole with evidence of foetal cardiac activity. Read More

J Clin Med 2022 Jun 13;11(12). Epub 2022 Jun 13.

Department of Assisted Reproduction, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, 639 Zhizaoju Rd, Shanghai 200011, China.

Ectopic pregnancy (EP) is increasingly found in women treated with in vitro fertilization and embryo transfer (IVF-ET). With the development of the freeze-all policy in reproductive medicine, it is controversial whether frozen embryo transfer (FET) could reduce the rate of EP. In this single-center, large-sample retrospective study, we analyzed 16,048 human chorionic gonadotrophin (hCG)-positive patients who underwent fresh embryo transfer (ET) or FET cycles between January 2013 and March 2022. Read More

Int J Mol Sci 2022 Jun 16;23(12). Epub 2022 Jun 16.

Université Paris Cité, CNRS, ITODYS, F-75013 Paris, France.

causes the most common sexually transmitted bacterial infection and trachoma, an eye infection. Untreated infections can lead to sequelae, such as infertility and ectopic pregnancy in women and blindness. We previously enhanced the antichlamydial activity of the fluoroquinolone ciprofloxacin by grafting a metal chelating moiety onto it. Read More

Healthcare (Basel) 2022 Jun 8;10(6). Epub 2022 Jun 8.

Department of Obstetrics and Gynecology, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania.

Copper T intrauterine devices (IUDs) are a popular long-acting reversible contraceptive method. The most common reasons for contraceptive failure are expulsion and extrauterine migration. We report a case of a 28-year-old female, G13P3, 37 weeks pregnant, who presented to the hospital for left abdominal flank pain. Read More

Diagnostics (Basel) 2022 Jun 10;12(6). Epub 2022 Jun 10.

Department of Obstetrics and Gynaecology, University Emergency Hospital Bucharest, 050098 Bucharest, Romania.

(1) Background: A quarter of maternal deaths are caused by post-partum hemorrhage; hence obstetric bleeding is a significant cause of morbidity and mortality among women. Pelvic artery embolization (PAE) represents a minimally invasive interventional procedure which plays an important role in conservative management of significant bleeding in Obstetrics and Gynecology. The aim of this study was to evaluate the effect and the complications of PAE in patients with significant vaginal bleeding with different obstetrical and gynecological pathologies. Read More

Patient Educ Couns 2022 Jun 18. Epub 2022 Jun 18.

Albany Medical Center, Department of Obstetrics and Gynecology, 43 New Scotland Ave. MC-74, Albany, NY 12208, USA. Electronic address:

Objectives: To evaluate the effect of the Ryan Program for family planning training on patient counseling surrounding previable pregnancy loss.

Methods: We conducted a retrospective cohort study of patients with first- and second-trimester miscarriages, therapeutic abortions, ectopic and molar pregnancies, from years before and after establishing a Ryan Program. We compared documentation of coping and future reproductive goals by patient factors, using chi square testing and logistic regression. Read More

In Vivo 2022 Jul-Aug;36(4):1570-1579

Whipps Cross University Hospital, Barts Health NHS Trust, London, U.K.

Background/aim: During the COVID-19 pandemic, concerns regarding theoretical risks of surgery contributed to changes in clinical management to prevent contamination. We looked at the effect the pandemic had on the management of ectopic pregnancy. Our review compares published data on pre-COVID to COVID management of ectopic pregnancies and evaluates the differences where Early Pregnancy Unit (EPU) structures exist. Read More

Reprod Toxicol 2022 Jun 20. Epub 2022 Jun 20.

Medicinal Safety Research Laboratories, Daiichi Sankyo Co., Ltd., 1-16-13 Kita-Kasai, Edogawa-ku, Tokyo, Japan.

We previously revealed that insulin-induced severe and long-lasting maternal hypoglycemia in rats caused anophthalmia and microphthalmia in fetuses; however, it remained unclear whether hypoglycemia-induced eye anomalies were developmental retardation or disruption, and when and how they developed. Hence, we induced hypoglycemia in pregnant Sprague-Dawley rats by injecting insulin from Days 6 to 11 of pregnancy and performed periodical histopathological examination of fetal eyes from embryonic days (E)10 to 20. On E10, optic vesicle had developed normally both in the control and insulin-treated group; however, on E11, optic cup (OC) had developed in the control group but not in the insulin-treated group. Read More

Case Rep Pathol 2022 13;2022:1966025. Epub 2022 Jun 13.

Department of Pathology, Centre Hospitalier Universitaire Brugmann, Place Arthur Van Gehuchten 4, 1020 Brussels, Belgium.

Ectopic liver tissue represents a rare entity and is mostly attributed to events occurring during embryogenesis. Previous case reports documented the presence of fetal liver parenchyma within temporarily developed organs during pregnancy, such as the placenta or the umbilical cord. Moreover, the terminology of these benign findings varies from "ectopic liver" to "hepatocellular adenoma-like neoplasm" or "hepatocellular adenoma". Read More

Front Endocrinol (Lausanne) 2022 3;13:889029. Epub 2022 Jun 3.

Shandong Provincial Clinical Medicine Research Center for Reproductive Health, Shandong University, Jinan, China.

Objective: This study aims to evaluate the association between polycystic ovary syndrome (PCOS) phenotypes and adverse perinatal outcomes, comparing the characteristics, ovarian response, and assisted reproductive outcomes in patients with various PCOS phenotypes after fertilization (IVF)/intracytoplasmic sperm injection (ICSI).

Methods: This study comprised 6,732 patients who underwent the first cycle of IVF/ICSI treatment in our outpatient department from January 2017 to July 2018. Propensity score matching (PSM) was used in PCOS and non-PCOS groups to balance the influence of intergroup confounding factors. Read More

SAGE Open Med Case Rep 2022 14;10:2050313X221104034. Epub 2022 Jun 14.

Department of Obstetrics and Gynecology, Liaocheng People's Hospital, Liaocheng, P.R. China.

Rudimentary uterine horn pregnancy is a rare and serious type of ectopic pregnancy and is hard to diagnose due to a lack of typical clinical symptoms at the early stage. A 35-year-old woman who was17 weeks pregnant and had a complicated history of infertility came to our hospital complaining of abdominal pain without vaginal bleeding. Computed tomography scan after 12 hours showed that her pregnancy was in the small cavity of a rudimentary uterine horn, which had ruptured. Read More

Adv Biomed Res 2022 30;11:27. Epub 2022 Mar 30.

Department of Obstetrics and Gynecology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.

Background: Ectopic pregnancy (EP) occurs in 1% of pregnancies, and may seriously effects on women's health and future fertility so this study aimed to compare the results of hysterosalpingography (HSG) after treatment of EP by laparoscopy, laparotomy, and methotrexate (MTX) therapy.

Materials And Methods: This was a clinical trial study was done on 112 EP women with treatment indication referred to Isfahan Al-Zahran and Shahid Beheshti Hospitals from 2017 to 2018. They were divided into 33 populated groups of laparoscopic salpingostomy, laparotomy and MTX. Read More

Asian J Surg 2022 Jun 16. Epub 2022 Jun 16.

Department of Reproductive Medicine, Chengdu Jinjiang Maternal and Child Health Hospital, Chengdu, 610041, Sichuan, China.

J Inherit Metab Dis 2022 Jun 17. Epub 2022 Jun 17.

Department of Renal Medicine, Queen Elizabeth Hospital Birmingham, Birmingham, UK.

Background: Cystinosis is a rare autosomal recessive disease leading to end stage renal disease within the second or third decade of life. Since the era of specific treatment with cysteamine, prognosis has substantially improved and pregnancy becomes an increasing concern.

Methods: Pregnancy data in patients with cystinosis were collected through an anonymised survey. Read More

Medicine (Baltimore) 2022 Jun 17;101(24):e29514. Epub 2022 Jun 17.

Department of Obstetrics and Gynecology, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Foundation, and Tzu Chi University, Hualien, Taiwan.

Abstract: Ectopic pregnancy is the most common cause of maternal mortality in the first trimester of pregnancy. The aim of this study was to find risk factors and clinical characteristics associated with ruptured ectopic pregnancies at a medical center in eastern Taiwan in a 19-year period. This was a retrospective observational study that included patients diagnosed with ectopic pregnancy between August 1999 and December 2018. Read More

Medicine (Baltimore) 2022 Jun 17;101(24):e29421. Epub 2022 Jun 17.

Department of Anesthesiology, Affiliated Hospital of North Sichuan Medical College, Nanchong, China.

Rationale: Patients with a single ventricle, who have not undergone surgery, reportedly have a lower survival rate. Furthermore, multiple pregnancies are rare among these females. We reported a case of anesthesia management of cesarean section in an uncorrected single-ventricular multi-pregnancy woman and review the anesthesia management of the published similar cases. Read More

Indian J Crit Care Med 2022 Feb;26(2):228-230

Department of Cardiology, Farhat Hached University Hospital Center, Sousse, Tunisia.

Background: Takotsubo syndrome is a transient stunned myocardium that typically involves the apical and mid-ventricular segments. A variant, called Inverted Takotsubo, concerns the basal and mid-ventricular segments.

Case Summary: We present a ruptured ectopic pregnancy that was responsible for a catecholamine surge, which led to this stress-induced cardiomyopathy. Read More

J Midlife Health 2022 Jan-Mar;13(1):85-87. Epub 2022 May 2.

Department of Obstetrics and Gynecology, Asian Institute of Medical Sciences, Faridabad, Haryana, India.

Abnormal uterine bleeding (AUB) is frequently encountered in the gynecological complaint of perimenopausal female visiting the outpatient department. Beginning in mid-40s, perimenopause is often marked with menstrual irregularities. Intramyometrial pregnancy (IMP) is a rare type of ectopic pregnancy with an incidence of <1% of all ectopic gestation may present as AUB in perimenopausal female. Read More

Reprod Sci 2022 Jun 14. Epub 2022 Jun 14.

Department of Gynecology and Obstetrics, Faculty of Medicine, Zagazig University, Zagazig, Egypt.

Letrozole, an aromatase inhibitor, has recently been introduced as a favorable medical treatment for ectopic pregnancy. We aimed at evaluating the effects of different doses of letrozole for termination of ectopic pregnancy and study their effects on villous trophoblastic tissue. Sixty patients with undisturbed ectopic pregnancy were classified into three equal groups. Read More

Sci Rep 2022 Jun 14;12(1):9905. Epub 2022 Jun 14.

Population Health Unit, Finnish Institute for Health and Welfare, Helsinki and Oulu, Finland.

Preterm birth at very low birth weight (VLBW, < 1500 g) is associated with an accumulation of cardiovascular and metabolic risk factors from childhood at least to middle age. Small-scale studies suggest that this could partly be explained by increased visceral or ectopic fat. We performed magnetic resonance imaging on 78 adults born preterm at VLBW in Finland between 1978 and 1990 and 72 term same-sex siblings as controls, with a mean age of 29 years. Read More

Clin Pract Cases Emerg Med 2022 May;6(2):129-132

North Shore University Hospital, Department of Emergency Medicine, Manhasset, New York.

Introduction: Ruptured ectopic pregnancy is one of the leading causes of maternal death. Point-of-care ultrasound (POCUS) has been shown to be highly sensitive for excluding ectopic pregnancy. Ectopic pregnancy after a hysterectomy is a rare but life-threatening occurrence. Read More

Biol Futur 2022 Jun 11. Epub 2022 Jun 11.

Department of Molecular Biology, Institute of Genetic Engineering, 30, Thakurhat Road, Kolkata, West Bengal, 700128, India.

Although benzaldehyde, an aromatic aldehyde, has been declared safe for uses in food, conflicting reports exist regarding its genotoxic and cytotoxic potentials in organisms. Our present study is the first attempt to evaluate the effects of exposure of benzaldehyde on the entire course of development of a eukaryote model organism, Drosophila melanogaster. Total time required for the initial appearance of the third instar larvae, pupae and adults increased dose dependently with the increasing dietary concentration of benzaldehyde. Read More

J Med Ultrason (2001) 2022 Jun 11. Epub 2022 Jun 11.

Obstetrics and Gynecology, Yodogawa Christian Hospital, 1-7-50 Kunijima, Higashiyodogawa-ku, Osaka, 533-0024, Japan.

Ultrasound is a minimally invasive technique recommended for the evaluation of abdominal pain in young, premenopausal women and pregnant women. Ectopic pregnancy, ovarian cyst torsion, ovarian hemorrhage, myoma degeneration, and pyometra can be detected with point-of-care ultrasound (POCUS) in the case of acute abdominal pain. This article describes the utility of POCUS in females with abdominal pain in obstetrics and gynecological diseases. Read More

Reprod Biomed Online 2022 Apr 30. Epub 2022 Apr 30.

Department of Obstetrics and Gynaecology, UMC location University of Amsterdam, Meibergdreef 9 Amsterdam, the Netherlands.

Research Question: How do hospitals with and without an early pregnancy assessment unit (EPAU) adhere to guideline-based quality indicators for an EPAU relating to logistics, access to services and quality of early pregnancy care?

Design: A qualitative interview study assessing the adherence to 19 quality indicators in four hospitals with an EPAU and four hospitals without an EPAU in the Netherlands. For each quality indicator, a ratio for guideline adherence was calculated. Overall non-adherence per hospital was defined as less than 100% adherence to the 19 quality indicators. Read More

Pan Afr Med J 2022 11;41:200. Epub 2022 Mar 11.

Département de Gynécologie et Obstétrique, Université de Yaoundé I, Yaoundé, Cameroun.

Introduction: the purpose of this study was to identify factors associated with the failure of medical treatment for ectopic pregnancy (EP) in women at the Yaoundé Gynaecology, Obstetrics and Pediatrics Hospital.

Methods: we conducted a case-control study using a retrospective data collection over a 10-year period from January 1 2008 to December 31 2017. Our study included all patients treated for EP; the study group was composed of patients in whom medical treatment had been unsuccessful while the control group was composed of patients in whom medical treatment had been successful. Read More

Int J Mol Sci 2022 May 31;23(11). Epub 2022 May 31.

Department of Pathophysiology, Jagiellonian University Medical College, 31-121 Krakow, Poland.

Oxygen balance is crucial for angiogenesis, immunity, and tissue repair. The human oviduct is essential for reproductive function, and any imbalance in homeostasis leads to fertility disturbances and might be a reason for ectopic pregnancy development. Uterine myoma is a widespread benign tumour, which is often accompanied by infertility. Read More

J Obstet Gynaecol 2022 Jun 9:1-6. Epub 2022 Jun 9.

Department of Reproductive Medicine, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.

This retrospective cross-sectional study was to investigate factors affecting clinical pregnancy in patients who received gonadotropin-releasing hormone agonist luteal phase long protocol (GnRH-a long protocol) and underwent fresh fertilisation (IVF)/intracytoplasmic sperm injection (ICSI) embryo transfer cycle. One thousand five hundred and twenty-five patients who received GnRH-a long protocol and underwent fresh IVF/ICSI embryo transfer cycle were enrolled. The clinical pregnancy rate (63. Read More

Global Health 2022 Jun 8;18(1):58. Epub 2022 Jun 8.

Shiraz Azad University, Dental Branch, Shiraz, Iran.

Background: Apart from infecting a large number of people around the world and causing the death of many people, the COVID-19 pandemic seems to have changed the healthcare processes of other diseases by changing the allocation of health resources and changing people's access or intention to healthcare systems.

Objective: To compare the incidence of endpoints marking delayed healthcare seeking in medical emergencies, before and during the pandemic.

Methods: Based on a PICO model, medical emergency conditions that need timely intervention was selected to be evaluated as separate panels. Read More

J Obstet Gynaecol 2022 Jun 7:1-7. Epub 2022 Jun 7.

Department of Obstetrics and Gynecology, The First Affiliated Hospital of Gannan Medical University, Ganzhou, China.

To compare the efficacies between ultrasound-guided curettage combined with hysteroscopic electro-resection after injection of pituitrin and hysteroscopic electro-resection after methotrexate chemotherapy in the treatment of caesarean scar pregnancy (CSP). 60 patients with CSP admitted to our hospital were selected as the study subjects, and divided into observation group ( 35) and control group ( = 25) in accordance with the therapeutic options. The observation group was treated with ultrasound-guided curettage combined with hysteroscopic electro-resection after injection of pituitrin, while the control group was treated with hysteroscopic electro-resection after methotrexate chemotherapy. Read More