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J Minim Invasive Gynecol 2019 Feb 15. Epub 2019 Feb 15.

Department of Obstetrics and Gynecology, Clinico University Hospital "Lozano Blesa", University of Zaragoza, Zaragoza, Spain.

Clin Pract Cases Emerg Med 2019 Feb 29;3(1):62-64. Epub 2019 Jan 29.

Madigan Army Medical Center, Department of Emergency Medicine, Joint Base Lewis-McChord, Washington.

Tubal ectopic pregnancies are commonly diagnosed during the first trimester. Here we present a second-trimester tubal ectopic pregnancy that was previously misdiagnosed as an intrauterine pregnancy on a first-trimester ultrasound. A 39-year-old gravida 1 para 0 woman at 15 weeks gestation presented with 10 days of progressive, severe abdominal pain, along with vaginal bleeding and intermittent vomiting for two months. Read More

Clin Pract Cases Emerg Med 2019 Feb 22;3(1):51-54. Epub 2019 Jan 22.

University of Alabama at Birmingham, Department of Emergency Medicine, Birmingham, Alabama.

Ruptured ectopic pregnancy is the leading cause of first trimester maternal mortality. The diagnosis of ectopic pregnancy should always be suspected in patients with abdominal pain, vaginal bleeding or syncope. While the use of an intrauterine device (IUD) markedly reduces the incidence of intrauterine pregnancy, it does not confer equal protection from the risk of ectopic pregnancy. Read More

J Obstet Gynaecol Can 2019 Feb 13. Epub 2019 Feb 13.

Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, University of Ottawa, Ottawa, ON.

Gynecol Obstet Fertil Senol 2019 Feb 12. Epub 2019 Feb 12.

Service de Gynécologie Obstétrique, C.H.I. de Poissy Saint-Germain, Poissy, France; Unité de recherche EA 7285 - Risques cliniques et sécurité en santé des femmes et en santé périnatale (RISCQ), Université de Versailles-Saint-Quentin (UVSQ), Saint-Quentin-en-Yvelines, France.

J Ultrason 2018 ;18(75):355-358

1st Department of Obstetrics and Gynecology, Centre of Postgraduate Medical Education , Warsaw , Poland.

Heterotopic pregnancy is a rare, but potentially life-threatening pathology. The diagnosis of heterotopic pregnancy is still one of the biggest challenges in modern gynecology. The incidence of those pregnancies in natural conception is about 1:30000. Read More

Placenta 2019 Feb 4. Epub 2019 Feb 4.

Translational Obstetrics Group, Department of Obstetrics and Gynecology, Mercy Hospital for Women, University of Melbourne, Heidelberg, Victoria, 3084, Australia; Mercy Perinatal, Mercy Hospital for Women, Victoria, Australia. Electronic address:

Pregnancy complications such as fetal growth restriction and preeclampsia are diseases with limited biomarkers for prediction, and a complete lack of therapeutic options. We define placenta-enriched molecules as those that are highly expressed in the placenta relative to all other human tissues. Many exist including mRNAs, miRNAs and proteins. Read More

Int J Surg Case Rep 2019 Jan 29;55:179-182. Epub 2019 Jan 29.

Department of Reproductive Medicine, KK Women's and Children's Hospital, Singapore.

Introduction: Hysterosalpingography (HSG) is routinely performed in the mid-follicular phase of a woman's menstrual cycle for cavity and tubal patency assessment as a part of the infertility screening. A pre-procedural pregnancy test is not routinely required unless the patient reports abnormal menstrual bleeding or irregular menstrual pattern.

Presentation Of Case: We present the case of a 29 year-old sub fertile woman who had a HSG performed on day 12 of her menstrual cycle. Read More

Ultrasound Obstet Gynecol 2019 Feb 10. Epub 2019 Feb 10.

Robinson Research Institute and Adelaide Medical School, University of Adelaide, North Adelaide, 5006, Australia.

Objectives: To compare the effectiveness and safety of tubal flushing with oil- or water-based contrast medium, alone or in combination, with each other or no tubal flushing in women with infertility; and to evaluate the effectiveness of tubal flushing on fertility outcomes over time.

Methods: We performed a systematic review and network meta-analysis. We searched electronic databases (MEDLINE, EMBASE and Cochrane Central Register of Controlled Trials) and trial registries up to 25 September 2018. Read More

Acta Obstet Gynecol Scand 2019 Feb 8. Epub 2019 Feb 8.

Department of Clinical Sciences, Danderyd Hospital, Karolinska Institute, Stockholm, Sweden.

Introduction: The objective was to investigate the Pearl index for ectopic pregnancy in women using levonorgestrel intrauterine system (LNG-IUS) at time of conception.

Material And Methods: This was a sub-study of a hospital based historical cohort including women with an ectopic pregnancy diagnosed in four referral hospitals in Stockholm Sweden between December 2013 and April 2017. Study participants and type of contraception at time of conception were identified through the electronic medical chart system. Read More

Arch Gynecol Obstet 2019 Feb 8. Epub 2019 Feb 8.

CHU Toulouse, Pôle de Gynécologie Obstétrique, Department of Obstetrics and Gynecology, Hôpital Paule de Viguier, 31059, Toulouse, France.

Introduction: We aimed to assess the prognostic significance of early βhCG change and baseline progesterone level on treatment outcome among women receiving single dose Methotrexate protocol for tubal ectopic pregnancy (EP).

Material And Methods: Retrospective study involving all consecutive patients diagnosed with EP and receiving Methotrexate therapy form January 2015 to December 2016. Patients were stratified into 2 groups according to treatment outcome: success group (n = 66) involved women who displayed complete resolution of serum βhCG levels following a single course of Methotrexate; failure group (n = 55) included patients who required repeated Methotrexate administration and/or surgical management. Read More

Case Rep Womens Health 2019 Jan 23;21:e00096. Epub 2019 Jan 23.

Genesis Fertility, Division of Reproductive Endocrinology & Infertility at Maimonides Medical Center, 6010 Bay Pkwy., Brooklyn, New York, USA.

Objective: To present a case of abnormally trending hCG levels due to ovarian hyperstimulation syndrome (OHSS) and to portray the obscurities of this commonly used method for tracking early pregnancies.

Design: Case report.

Setting: Outpatient ART facility. Read More

Case Rep Womens Health 2019 Jan 14;21:e00095. Epub 2019 Jan 14.

Royal Prince Alfred Hospital, Research Institute, Missenden Road, Camperdown, NSW, Australia.

2% of all pregnancies are ectopic. Optimal surgical management is currently salpingectomy over salpingostomy, secondary to the risks of persistent trophoblastic tissue or omental implants (15%). However, rare cases of omental trophoblastic implants following laparoscopic salpingectomy have been noted in the literature. Read More

Biomed Rep 2019 Feb 29;10(2):113-118. Epub 2018 Nov 29.

Department of Reproductive Medicine, Linyi People's Hospital, Linyi, Shandong 276003, P.R. China.

The aim of the present study was to evaluate the influence of a gonadotropin-releasing hormone (GnRH) antagonist compared with a GnRH agonist on fertilization (IVF) cycle outcome in reproductive women. The characteristics of treatment and outcomes of pregnancy were retrospectively compared between the antagonist (GnRH-A, antagonist group) and agonist (GnRH-a, agonist group) regimens. The area under the curve (AUC) of receiver operating characteristic (ROC) curves was also used to evaluate whether the endometrial thickness (cm), progesterone (P) level (ng/ml) and estradiol (E) level (pg/ml) on the day of human chorionic gonadotropin (hCG) administration (hCG day) had the ideal sensitivity and specificity for predicting clinical pregnancy. Read More

ACS Appl Mater Interfaces 2019 Feb 4. Epub 2019 Feb 4.

We present an improved approach for the preparation of highly selective and homogeneous molecular cavities in molecularly imprinted polymers (MIP) via the combination of surface imprinting and semi-covalent imprinting. Towards that, first a colloidal crystal mold was prepared via the Langmuir-Blodgett technique. Then, human chorionic gonadotropin (hCG) template protein was immobilized on the colloidal crystal mold. Read More

Best Pract Res Clin Obstet Gynaecol 2019 Jan 3. Epub 2019 Jan 3.

Assisted Reproductive Technology Unit, Department of Obstetrics and Gynaecology, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong. Electronic address:

In this systematic review, we analysed the reproductive outcomes of hysteroscopic adhesiolysis in women with Asherman syndrome (AS). We searched PubMed, Web of Science and Cochrane Library (from database inception to April 2018) and selected studies that quantitatively described the reproductive outcomes. We assessed study quality and pooled rate data for each outcome. Read More

Adv Clin Exp Med 2019 Jan 31. Epub 2019 Jan 31.

Center of Reproductive Medicine, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, China.

Background: In thawed embryo transfer cycles, the most common method is to transfer the embryos after 2 h of culture. Clinical outcomes of frozen-thawed cleavage embryo transfer cycles regarding the embryos status and the culture time of frozen-thawed cleavage embryos were limited and did not elucidate all unclear issues.

Objectives: The objective of this study was to examine the clinical outcomes of frozen-thawed cleavage embryo transfer cycles according to the embryos status and the culture time (2 h or overnight). Read More

Int J Gynaecol Obstet 2019 Feb 1. Epub 2019 Feb 1.

Regional Coordinator for Central America and Caribbean, FIGO Initiative on Prevention of Unsafe Abortion, San Salvador, El Salvador.

Am J Obstet Gynecol 2019 Jan 29. Epub 2019 Jan 29.

Instituto Maimónides de Investigación Biomédica de Cordoba (IMIBIC); Department of Cell Biology, Physiology and Immunology, University of Cordoba; Hospital Universitario Reina Sofia; CIBER Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, Cordoba, Spain; Institute of Biomedicine, University of Turku, Turku, Finland. Electronic address:

Background: Ectopic pregnancy (EP) is a life-threatening condition, for which novel screening tools enabling early accurate diagnosis would improve clinical outcomes. Kisspeptins, encoded by KISS1, play an essential role in human reproduction, at least partially by regulating placental function and possibly embryo implantation. Kisspeptin levels are massively elevated in normal pregnancy and reportedly altered in various gestational pathologies. Read More

Am Fam Physician 2019 Feb;99(3):166-174

University of Michigan Medical School, Ann Arbor, MI, USA.

Approximately one-fourth of pregnant women will experience bleeding in the first trimester. The differential diagnosis includes threatened abortion, early pregnancy loss, and ectopic pregnancy. Pain and heavy bleeding are associated with an increased risk of early pregnancy loss. Read More

Case Rep Obstet Gynecol 2018 31;2018:8190805. Epub 2018 Dec 31.

MyHealth Centre, London, ON, Canada.

Ovarian pregnancy is a rare subtype of ectopic pregnancy with an increased incidence after assisted conception. We present a 31-year-old gestational carrier who presented with suprapubic and pelvic pain at 6 weeks and 2 days' gestation. An ultrasound scan demonstrated an empty uterus and a complex mass in the left adnexa. Read More

J Minim Invasive Gynecol 2019 Jan 25. Epub 2019 Jan 25.

Department of Medical, Surgical, and Health Sciences, University of Trieste, 34149 Trieste, Italy.

Study Objective: To evaluate the efficacy of a total surgical treatment of ectopic cervical pregnancy, with a minimally invasive approach performed by hysteroscopy.

Design: Step-by-step video demonstration of the surgical technique using 5 mm hysteroscopy followed by 10 mm resectoscopy.

Setting: A Research and University Hospital; IRCCS Burlo Garofolo of Trieste, Italy. Read More

North Clin Istanb 2018 Sep;5(3):227-231

Department of Obstetrics and Gynecology, Sisli Hamidiye Etfal Training and Research Hospital, Istanbul.

Objective: It is controversial whether medical or surgical treatment options have more successful results in ectopic pregnancy treatment. Although high pretreatment serum hCG levels have been known to be the most important predictor, the appropriate treatment modality for a specific range of hCG level remains unclear. Furthermore, the variables that make a patient a bad candidate for single-dose methotrexate treatment is unclear. Read More

J Turk Ger Gynecol Assoc 2019 Jan 28. Epub 2019 Jan 28.

Department of Obstetrics and Gynecology, All India Institute of Medical Sciences, New Delhi, India

Front Surg 2018 9;5:79. Epub 2019 Jan 9.

Department of Obstetrics and Gynecology, St-Vincent Clinic, Rocourt, Belgium.

To evaluate the pregnancy and delivery rates of laparoscopic tubal reanastomosis. From 2003 to 2013, 135 laparoscopic tubal reversals were performed according to the four stitch technique. The parameters studied, included positive pregnancy test, miscarriage, ectopic pregnancy, termination of pregnancy, term delivery, post-operative time to conception, post-operative hysterosalpingography, and spermogram. Read More

J Assist Reprod Genet 2019 Jan 25. Epub 2019 Jan 25.

Virginia Center for Reproductive Medicine, Reston, VA, USA.

Purpose: The aim of the systematic review is to describe the obstetrical complications associated with pregnancies in the context of a thin endometrial lining.

Methods: Systematic review of the literature.

Results: Patients who conceive in the setting of a thin endometrium have a significantly increased risk of early pregnancy loss, namely miscarriage and ectopic pregnancy. Read More

Fertil Steril 2019 Jan 22. Epub 2019 Jan 22.

Unit of Gynecology and Obstetrics, Department of Women and Children's Health, University of Padua, Padua, Italy.

Objective: To investigate endometrial scratch injury (ESI) as an intervention to improve IVF outcome in women undergoing a first ET.

Design: Systematic review and meta-analysis.

Setting: Not applicable. Read More

Medicine (Baltimore) 2019 Jan;98(4):e14211

Division of Pediatric Surgery, Department of Surgery, Jichi Medical University School of Medicine, Shimotsuke, Tochigi, Japan.

Rationale: Liver heterotopia associated with congenital diaphragmatic hernia (CDH) is a rare condition; to the best of our knowledge, only 17 cases have been reported to date. The histogenesis and clinicopathological features are largely unknown. We herein report 2 cases of liver heterotopia associated with CDH along with 17 cases described in the literature to shed light on their clinicopathological characteristics. Read More

Medicine (Baltimore) 2019 Jan;98(4):e14193

Department of Obstetrics and Gynecology, Chia-Yi Chang Gung Memorial Hospital.

Rationale: Tubal sterilization as a contraception method has a high success rate; however, it also carries a low risk of incidental pregnancy. A majority of these pregnancies are ectopic. In this study, we report a rare case of spontaneous right distal tubal pregnancy after bilateral laparoscopic tubal sterilization. Read More

Int J Hyperthermia 2019 Jan 24:1-4. Epub 2019 Jan 24.

a Department of Obstetrics and Gynecology , The Third Xiangya Hospital of Central South University , Changsha , Hunan Province , China.

Objective: Cervical pregnancy (CP) is a rare type of ectopic pregnancy and is considered to be a life-threatening condition due to the risk of severe hemorrhage. Unfortunately, no consensus on standard conservative treatment for CP has been established. The study objective was to evaluate the efficacy and safety of high-intensity focused ultrasound (HIFU) followed by suction curettage for cervical pregnancy. Read More

BMJ Case Rep 2019 Jan 22;12(1). Epub 2019 Jan 22.

Department of Diagnostic and Interventional Imaging, McGovern Medical School-UTHealth, Houston, Texas, USA.

BMC Nephrol 2019 Jan 23;20(1):24. Epub 2019 Jan 23.

Division of Neonatology, Cincinnati Children's Hospital and Medical Center, Cincinnati, OH, USA.

Background: Reproductive function in women with end stage renal disease generally improves after kidney transplant. However, pregnancy remains challenging due to the risk of adverse clinical outcomes.

Methods: We searched PubMed/MEDLINE, Elsevier EMBASE, Scopus, BIOSIS Previews, ISI Science Citation Index Expanded, and the Cochrane Central Register of Controlled Trials from date of inception through August 2017 for studies reporting pregnancy with kidney transplant. Read More

N Engl J Med 2019 01;380(4):325-334

From the Department of Obstetrics and Gynaecology, University of Auckland (S.L., D.O., C.F.), and Women's Health (L. Sadler) and Fertility Plus (D.G., C.F.), Auckland District Health Board, Auckland, Fertility Associates, Christchurch (S.A.W.), and Fertility Associates, Wellington (L. Searle, S.M.) - all in New Zealand; Bath Fertility Centre, Bath (S.A., E.N.), the Department of Medical Statistics, Manchester University NHS Foundation Trust, Manchester (J.W.), and the Department of Obstetrics and Gynaecology, King's College Hospital (K.V., H.H.), University College Hospital (L.W.), Homerton Fertility Centre, Homerton University Hospital NHS Foundation Trust (P.B.), and Guy's Hospital (Y.K.), London - all in the United Kingdom; the Department of Obstetrics and Gynecology, Institute of Clinical Sciences, University of Gothenburg, Reproductive Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden (C.S., A.S., C.B.); Leuven University Fertility Center, Department of Obstetrics and Gynecology, University Hospitals, Leuven, Belgium (A.H., K.P.); and Reproductive Services, Royal Women's Hospital, Melbourne, VIC, Australia (W.T.T.).

Background: Endometrial scratching (with the use of a pipelle biopsy) is a technique proposed to facilitate embryo implantation and increase the probability of pregnancy in women undergoing in vitro fertilization (IVF).

Methods: We conducted a pragmatic, multicenter, open-label, randomized, controlled trial. Eligible women were undergoing IVF (fresh-embryo or frozen-embryo transfer), with no recent exposure to disruptive intrauterine instrumentation (e. Read More

Am J Reprod Immunol 2019 Jan 23:e13093. Epub 2019 Jan 23.

Department of Obstetrics & Gynaecology, The University of Hong Kong, Hong Kong, SAR, China.

Tubal ectopic pregnancy (TEP) refers to implantation of conceptus in the fallopian tube. It makes up over 98% of ectopic pregnancy (EP), which is the leading cause of maternal morbidity and mortality in the first trimester of pregnancy. Immune cells at the maternal-fetal interface play important roles in the process of embryo implantation, stroma decidualization, and early placental development. Read More

Int J Mol Sci 2019 Jan 19;20(2). Epub 2019 Jan 19.

Department of Experimental and Clinical Medicine and DENOTHE Excellence Center, University of Florence, 50134 Florence, Italy.

Trophoblast expressing paternal HLA-C resembles a semiallograft, and could be rejected by maternal T cells. IL-22 seems to be involved in allograft rejection and thus could be responsible for miscarriages. We examined the role of decidual IL-22-producing CD4+ T on human pregnancy. Read More

J Cancer 2019 1;10(1):28-34. Epub 2019 Jan 1.

Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan.

The aim of the study was to determine the association between pelvic inflammatory disease (PID) and breast, colorectal, gynecologic and urinary tract cancer. The source of data was a longitudinal dataset compiled by the Longitudinal Health Insurance Database 2000 (LHID2000) which was collected by the National Health Insurance program. Cases of PID, at least two outpatient visits and one admission, were diagnosed from 2000 to 2013. Read More

Reprod Med Biol 2019 Jan 11;18(1):51-56. Epub 2018 Oct 11.

Department of Gynecology and Obstetrics Kyoto University Kyoto Japan.

Purpose: To investigate the role of beta-human chorionic gonadotropin (HCG) level and its change prior to methotrexate (MTX) treatment as predictors of treatment success and to access the posttreatment observation period for ectopic tubal pregnancy.

Methods: Clinical data of 41 females treated with MTX for tubal pregnancies were reviewed and analyzed retrospectively.

Results: Among 41 patients, 34 achieved complete resolution without surgery. Read More

Gynecol Obstet Invest 2019 Jan 17:1-5. Epub 2019 Jan 17.

Department of Obstetrics and Gynecology, TOBB University Faculty of Medicine, Ankara, Turkey.

Background: Consecutive measurements of β-hCG levels and sonographic evaluation of adnexae are critical for choosing the optimal management in ampullar tubal ectopic pregnancies (EP). To select suitable patients for conservative approach, there is a need for an affordable and reliable marker for determining rupture risk. Evaluation of systemic inflammatory markers in combination with serum β-hCG levels and ultrasound might help to decide the appropriate treatment option. Read More

Medicine (Baltimore) 2019 Jan;98(3):e13872

Department of Obstetrics and Gynecology, People's Hospital of Zhengzhou University.

Rationale: Intrauterine device (IUD) is commonly used in China. Its complications include uterine perforation, IUD ectopic migration, etc. However, a migrated IUD rarely leads to renal failure. Read More

Infect Disord Drug Targets 2019 Jan 17. Epub 2019 Jan 17.

Department of Parasitology, school of medicine, Ilam University of Medical Sciences, Ilam. Iran.

Trichomoniasis is known as a common venereal disease. It is estimated that 180 million people in the world are infected with this disease. The present study was conducted to estimate the prevalence of (Trichomonas vaginalis) T. Read More

Biol Reprod 2019 Jan 14. Epub 2019 Jan 14.

Department of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo.

A decellularized uterine scaffold (DUS) prepared from rats permits recellularization and regeneration of uterine tissues when placed onto a partially excised uterus and supports pregnancy in a fashion comparable to the intact uterus. The underlying extracellular matrix (ECM) together with an acellular, perfusable vascular architecture preserved in DUS is thought to be responsible for appropriate regeneration of the uterus. To investigate this concept, we examined the effect of the orientation of the DUS-preserving ECM and the vascular architecture on uterine regeneration through placement of a DUS onto a partially defective uterine area in the reversed orientation such that the luminal face of the DUS was outside and the serosal face was inside. Read More

J Matern Fetal Neonatal Med 2019 Jan 27:1-6. Epub 2019 Jan 27.

a Department of Obstetrics and Gynecology , Shanghai General Hospital of Nanjing Medical University , Shanghai , China.

Background And Objectives: Most of previous studies are comparing the perinatal outcome on singleton babies. There has been no study evaluating the possible effect of singleton embryo transfer on the perinatal outcomes in initial singleton pregnancy resulting from fresh embryo transfer. The purpose of our study is to access the effect of embryo transfer number on obstetric and perinatal risks in order to examine the role of single embryo transfer on perinatal outcomes on initial singleton pregnancy. Read More

J Gynecol Obstet Hum Reprod 2019 Jan 11. Epub 2019 Jan 11.

Division of Child Health, Obstetrics & Gynaecology, University of Nottingham. Maternity, City Hospital, Hucknall Road, NG5 1PB, Nottingham, United Kingdom. Electronic address:

J Minim Invasive Gynecol 2019 Jan 9. Epub 2019 Jan 9.

Department of Obstetrics and Gynecology, Assuta Ashdod University Hospital, Ashdod, Israel (all authors), and the Faculty of Health Sciences, Ben-Gurion University, Beersheba, Israel (Dr. Barel).

Study Objective: To describe the presentation, diagnosis, and management of a patient with abdominal pregnancy and to illustrate the laparoscopic technique used to manage this patient.

Design: A descriptive study approved by our local Institutional Review Board. Consent was given from the patient. Read More

Am J Case Rep 2019 Jan 14;20:53-59. Epub 2019 Jan 14.

Laboratory of Age-Related Metabolic and Endocrine Disorders, The Russian Gerontology Clinical Research Center, Moscow, Russian Federation.

BACKGROUND Primary hyperparathyroidism is most common in women during the menopause and its occurrence in pregnant women is rare. However, because neonatal mortality is associated with maternal hyperparathyroidism, early diagnosis is essential. This report describes the case of a late diagnosis of primary hyperparathyroidism in a 28-year-old pregnant woman and describes the effects on the mother and neonate. Read More

BMJ Sex Reprod Health 2019 Jan 13. Epub 2019 Jan 13.

Chalmers Centre for Sexual Health, NHS Lothian, Edinburgh, UK.

Introduction: Women may seek abortion at gestations when there is no visible intrauterine pregnancy on ultrasound scanning. Clinical protocols for pregnancy of unknown location (PUL) require measurement of serum human chorionic gonadotrophin (hCG), with the National Institute for Health and Care Excellence recommending that values above 1500 IU/L be further investigated to exclude ectopic pregnancy. Our aim was to determine whether a point-of-care test (POCT) could be used instead of laboratory serum hCG measurement. Read More

Emerg Radiol 2019 Jan 10. Epub 2019 Jan 10.

Department of Radiology, Henry Ford Hospital, Detroit, MI, USA.

Over the past 40 years since the first in vitro fertilization was performed, both the role of assisted reproductive technology (ART) in establishing viable pregnancy as well as the available treatment options have expanded enormously. Annually in the USA, nearly 2% of pregnancies now employ some form of ART assistance, with in vitro fertilization (IVF) being the most commonly utilized methodology. Both maternal and fetal risks are elevated in ART pregnancies, the latter including adverse outcome due to both increased gestational number as well as advanced maternal age. Read More

Am J Obstet Gynecol 2019 Jan 7. Epub 2019 Jan 7.

Division of Reproductive Endocrinology and Infertility, University of Pennsylvania, Philadelphia, Pennsylvania.

Objective: To compare the treatment success and failure rates, as well as side effects and surgery rates between methotrexate protocols.

Data Sources: PubMed, Embase and the Cochrane library searched up till July 2018.

Study Eligibility Criteria: RCTs that compared women with ectopic pregnancies receiving the single dose, two dose or multi-dose methotrexate protocols. Read More

Lasers Med Sci 2019 Jan 9. Epub 2019 Jan 9.

Zhongshan Hospital, Fudan University, NO. 180 Fenglin Road, Shanghai, 200032, China.

Assisted hatching (AH) is initially developed to provide an artificial manipulation of the zona pellucida (ZP) to help embryos hatch and improve the capacity of the embryos to implant. However, these effects remain unclear and controversial because of variation in patient characteristics, and it is critical to ascertain the indications for AH and to identify those patients who might benefit from AH. Here, this study aimed to assess the effect of laser-assisted zona thinning hatching technology (LAH) during the frozen-thawed D3 embryos on pregnancy outcomes in patients with previous repeated failures in vitro fertilization-embryo transfer (IVF-ET). Read More

PLoS One 2019 9;14(1):e0207422. Epub 2019 Jan 9.

Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana, United States of America.

Problem: Chlamydia trachomatis infections are often associated with acute syndromes including cervicitis, urethritis, and endometritis, which can lead to chronic sequelae such as pelvic inflammatory disease (PID), chronic pelvic pain, ectopic pregnancy, and tubal infertility. As epithelial cells are the primary cell type productively infected during genital tract Chlamydia infections, we investigated whether Chlamydia has any impact on the integrity of the host epithelial barrier as a possible mechanism to facilitate the dissemination of infection, and examined whether TLR3 function modulates its impact.

Method Of Study: We used wild-type and TLR3-deficient murine oviduct epithelial (OE) cells to ascertain whether C. Read More