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FASEB J 2018 Dec 6:fj201800981R. Epub 2018 Dec 6.

Department of Anesthesiology, University of Maryland School of Medicine, Baltimore, Maryland, USA.

As mechanisms controlling redox homeostasis become impaired with aging, exaggerated oxidant stress may cause disproportional oxidation of cell membranes and circulating phospholipids (PLs), leading to the formation of truncated oxidized PL products (Tr-OxPLs), which exhibit deleterious effects. This study investigated the role of elevated Tr-OxPLs as a factor exacerbating inflammation and lung barrier dysfunction in an animal model of aging. Mass spectrometry analysis of Tr-OxPL species in young (2-4 mo) and aging (18-24 mo) mice revealed elevated basal levels of several products [1-palmitoyl-2-(5-oxovaleroyl)- sn-glycero-phosphocholine (POVPC), 1-palmitoyl-2-glutaroyl- sn-glycero-phosphocholine, lysophosphocholine, 1-palmitoyl-2-(9-oxo-nonanoyl)- sn-glycero-3-phosphocholine, 1-palmitoyl-2-azelaoyl- sn-glycero-3-phosphocholine, O-1-O-palmitoyl-2-O-(5,8-dioxo-8-hydroxy-6-octenoyl)-l-glycero-3-phosphocholine, and others] in the aged lungs. Read More

Tissue Eng Part A 2018 Dec 6. Epub 2018 Dec 6.

Kyungpook National University, Oral Microbiology , 2177 Dalgubeol-daero, Jung-gu , Daegu, Korea, Republic of , 41940 ;

Exosomes are membranous nanovesicles that naturally transport bio-molecules, including miRNAs, and play critical roles in intercellular communication. We found that the growth condition milieu of pre-osteoblast exosomes contains a high level of the let-7 miRNAs. After blocking exosome secretion, we found that osteogenic differentiation of pre-osteoblasts (MC3T3-E1 cells) decreased significantly whereas addition of exosomes from growth condition recovered osteogenic ability. Read More

J Obstet Gynaecol Res 2018 Dec 6. Epub 2018 Dec 6.

Department of Obstetrics and Gynecology, Gifu Prefectural Tajimi Hospital, Tajimi, Japan.

A 41-year-old woman (gravida 2, para 1) underwent elective termination of pregnancy at approximately 7 weeks of gestation. At 1 month after the elective abortion, she was referred due to abnormal results in a cervical cytological examination. Transvaginal ultrasonography showed a heterogeneous mass of 16 mm in diameter in the left adnexal region. Read More

Ir Med J 2018 06 7;111(6):774. Epub 2018 Jun 7.

Department of Gynaecology, the Adelaide and Meath National Children's Hospital, Dublin, Republic of Ireland

Caesarean scar ectopic pregnancy (CSEP) is one of the rarest forms of ectopic pregnancies. With rising caesarean delivery (CD) rates worldwide, there is an increase in the incidence of CSEP. Patients usually present with painless vaginal bleeding and often misdiagnosed as spontaneous miscarriage. Read More

Mol Ecol 2018 Dec 5. Epub 2018 Dec 5.

Carl von Ossietzky University Oldenburg, Institute for Biology and Environmental Sciences, Carl von Ossietzky Str. 9-11, 26111, Oldenburg, Germany.

Hybridization can induce transposons to jump into new genomic positions, which may result in their accumulation across the genome. Alternatively, transposon copy numbers may increase through non-allelic (ectopic) homologous recombination in highly repetitive regions of the genome. The relative contribution of transposition bursts versus recombination-based mechanisms to evolutionary processes remains unclear because studies on transposon dynamics in natural systems are rare. Read More

Eur J Nucl Med Mol Imaging 2018 Dec 5. Epub 2018 Dec 5.

Department of Nuclear Medicine, Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, China.

Radiologe 2018 Dec 5. Epub 2018 Dec 5.

Universitätsinstitut für Radiologie, Universitätsklinikum der Paracelsus Medizinischen Privatuniversität, Müllner Hauptstraße 48, 5020, Salzburg, Österreich.

Background: Acute pelvic pain in women may be due to gynecological, gastrointestinal, and urinary tract disorders. Ectopic pregnancy (EP), pelvic inflammatory disease (PID), and ruptured ovarian cysts are the most common gynecological causes for acute pelvic pain and their diagnosis can be challenging.

Methods: Patient history, clinical examination, and blood tests as well as patient age and potential pregnancy status help to establish the correct diagnosis. Read More

Onco Targets Ther 2018 9;11:7955-7965. Epub 2018 Nov 9.

General Surgery Department, Dazhou Central Hospital, Dazhou 635000, Sichuan, China,

Background: lncRNA differentiation antagonizing nonprotein coding RNA (lncRNA DANCR) has been suggested to play an oncogenic role in multiple cancers. However, to the best of our knowledge, the clinical significance and role of DANCR in pancreatic ductal adenocarcinoma (PDAC) has not been illuminated till now. The present study aims to identify the functional role of DANCR in PDAC. Read More

Cell Death Dis 2018 Dec 5;9(12):1174. Epub 2018 Dec 5.

Research Center of Biochemistry and Advanced Molecular Biology, Department of Experimental and Clinical Medicine, "Magna Græcia" University of Catanzaro, Campus Salvatore Venuta -Viale Europa, 88100, Catanzaro, Italy.

Ferritin is a nanocage protein composed by the variable assembly of 24 heavy and light subunits. As major intracellular iron storage protein, ferritin has been studied for many years in the context of iron metabolism. However, recent evidences have highlighted its role, in particular that of the heavy subunit (FHC), in pathways related to cancer development and progression, such as cell proliferation, growth suppressor evasion, cell death inhibition, and angiogenesis. Read More

Cell Death Dis 2018 Dec 5;9(12):1169. Epub 2018 Dec 5.

State Key Laboratory of Oncology in South China, Collaborative Innovation Centre of Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center, 510060, Guangzhou, China.

Nasopharyngeal carcinoma (NPC) progression is regulated by genetic, epigenetic, and epitranscript modulation. As one of the epitranscript modifications, the role of N6-Methyladenosine (mA) has not been elucidated in NPC. In the present study, we found that the poorly methylated gene ZNF750 (encoding zinc finger protein 750) was downregulated in NPC tumor tissues and cell lines. Read More

Endocr J 2018 Dec 4. Epub 2018 Dec 4.

Department of Metabolism & Endocrinology, Juntendo University Graduate School of Medicine, Tokyo, Japan.

Although metabolic abnormalities commonly occur in non-obese Asians, their pathogenesis is not fully understood. Proton magnetic resonance spectroscopy has been used to analyze intracellular lipids in humans, and results suggest that ectopic fat accumulation in muscle and liver may induce insulin resistance in each tissue independently of obesity. Thus, measurement of ectopic fat currently plays an important role in the study of insulin resistance in non-obese Asians. Read More

J Minim Invasive Gynecol 2018 Nov 30. Epub 2018 Nov 30.

Reproductive and Genetic Hospital of CITIC-XIANGYA, Changsha, China; Institute of Reproductive and Stem Cell Engineering, Basic Medicine College, Central South University, Changsha, China; Key Laboratory of Reproductive and Stem Cell Engineering, Ministry of Health, Changsha, China. Electronic address:

Study Objective: To investigate the effectiveness of Tornado and Hilal (Cook Medical, Bloomington, Indiana, USA) hysteroscopic proximal tubal occlusion (HPTO) for hydrosalpinx (HX) treatment prior to in vitro fertilization (IVF) and embryo transfer (ET) in patients with dense pelvic adhesions or low ovarian reserve.

Design: Retrospective study of patients treated between May 2014 and May 2016 (Canadian Task Force classification III).

Setting: University-affiliated center. Read More

Neurochem Int 2018 Nov 30. Epub 2018 Nov 30.

Department of Immunology, National Institute of Neuroscience, National Center of Neurology and Psychiatry (NCNP), 4-1-1 Ogawahigashi, Kodaira, Tokyo, 187-8502, Japan. Electronic address:

Reserch progresses in understanding the pathogenicity of multiple sclerosis (MS) in the last couple of decade has enabled us to develop new drug entities available in the clinic. However, we still have not succeeded in preventing conversion from relapsing-remitting MS (RR-MS) to secondary progressive MS (SP-MS) and curing this intractable form of MS. Furthermore, diagnosis is usually retrospective and subjective, relying on gradual worsening of neurological signs/symptoms. Read More

Biochem Cell Biol 2018 Dec 3. Epub 2018 Dec 3.

The First Affiliated hospital of China Medical University, Department of Orthopedic Surgery, Shenyang, China ;

Osteosarcoma (OS) is the most common malignant bone tumor in children and adolescents, and metastatic OS is the major cause of OS-related death. Carboxypeptidase E (CPE) is demonstrated to be highly expressed in some cancer types, and its N-terminal truncated form, CPE-ΔN, is implicated in tumor metastasis and poor prognosis. In this study, we investigated the effect of CPE-ΔN on cell migration, invasion and epithelial-mesenchymal transition (EMT) of OS cells, and illustrated the molecular mechanisms. Read More

Pigment Cell Melanoma Res 2018 Dec 2. Epub 2018 Dec 2.

Department of Dermatology and Allergy, University Hospital, LMU Munich, Frauenlobstr. 9-11, 80337, Munich, Germany.

The transcription factor sex determining region Y-box 10 (SOX10) plays a key role in the development of melanocytes and glial cells from neural crest precursors. SOX10 is involved in melanoma initiation, proliferation, invasion, and survival. However, specific mediators which impart its oncogenic properties remain widely unknown. Read More

J Investig Clin Dent 2018 Dec 2:e12377. Epub 2018 Dec 2.

Department of Maxillofacial Surgery, Faculty of Dentistry, Gaziosmanpasa University, Tokat, Turkey.

Aim: A mesiodens is the most frequent type of supernumerary tooth. They can be related to several complications, such as ectopic eruption and midline diastema. The aim of the present study was to assess the radiographic properties of mesiodens by analyzing the associated age, sex distribution, number of mesiodens per patient, shape, direction of eruption, and their association with complications. Read More

Physiol Plant 2018 Dec 2. Epub 2018 Dec 2.

College of Forestry, Shandong Agricultural University, Taian, Shandong, 271018, People's Republic of China.

The quality and quantity of mulberry leaves are often affected by various environmental factors. The plant NPR1 and its homologous genes are important for plant systemic acquired resistance. Here, the full-length cDNAs encoding the NPR1 and NPR4 genes (designated MuNPR1 and MuNPR4, respectively) were isolated from Morus multicaulis. Read More

Am J Reprod Immunol 2018 Nov 30:e13074. Epub 2018 Nov 30.

First Affiliated Hospital of Xiamen University, Xiamen, People's Republic of China.

Problem: The role of the long non-coding RNA (lncRNA) actin filament associated protein 1 antisense RNA1 (AFAP1-AS1) in the etiology of endometriosis is unknown.

Method Of Study: Expression of epithelial-mesenchymal transition (EMT) markers was quantified using qRT-PCR, immunohistochemistry, and western blotting. The proliferation, migration, and invasion of ectopic endometrial epithelial cells and Ishikawa cells were evaluated by MTT, EdU, wound healing, and transwell assays. Read More

Case Rep Womens Health 2018 Oct 9;20:e00086. Epub 2018 Nov 9.

Birmingham Cancer Research UK Cancer Centre, Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, B15 2TT, UK.

Chronic ectopic pregnancy (CEP) is a rare condition caused by implantation of trophoblastic tissue in the fallopian tube, which causes protracted tissue destruction at the site of attachment. The process of minor rupture and bleeding results in chronic inflammation, giving rise to a haematocele which often resembles a pelvic mass. Unlike ectopic pregnancy, the level of serum human chorionic gonadotropin (hCG) in patients with CEP is usually low or undetectable as chorionic villi are generally sparse. Read More

Nat Rev Drug Discov 2018 Nov 30. Epub 2018 Nov 30.

Faculty of Biology & Biotechnology, Department of Cell Physiology, Ruhr-University Bochum, Bochum, Germany.

Olfactory and taste receptors are expressed primarily in the nasal olfactory epithelium and gustatory taste bud cells, where they transmit real-time sensory signals to the brain. However, they are also expressed in multiple extra-nasal and extra-oral tissues, being implicated in diverse biological processes including sperm chemotaxis, muscle regeneration, bronchoconstriction and bronchodilatation, inflammation, appetite regulation and energy metabolism. Elucidation of the physiological roles of these ectopic receptors is revealing potential therapeutic and diagnostic applications in conditions including wounds, hair loss, asthma, obesity and cancers. Read More

Cell Physiol Biochem 2018 Nov 30;51(4):1658-1678. Epub 2018 Nov 30.

Protein Folding and Dynamics Laboratory, Structural Biology and Bioinformatics Division, CSIR-Indian Institute of Chemical Biology, Kolkata, India.

Background/aims: The conformation, folding and lipid binding properties of the intestinal fatty acid binding proteins (IFABP) have been extensively investigated. In contrast, the functional aspects of these proteins are not understood and matter of debates. In this study, we aim to address the deleterious effects of FA overload on cellular components, particularly mitochondria; and how IFABP helps in combating this stress by restoring the mitochondrial dynamics. Read More

Anticancer Res 2018 Dec;38(12):6653-6662

Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy.

Background: Poorly differentiated (PDTC) and anaplastic thyroid (ATC) cancer cells are characterized by the acquisition of epigenetic abnormalities, leading to the silencing of both the sodium iodide co-transporter and the Coxsackie adenovirus receptor. As aberrant histone acetylation and DNA methylation represent epigenetic mechanisms involved in neoplastic transformation, our study investigated the anticancer properties of epigenetic modifiers in thyroid carcinoma.

Materials And Methods: The cytotoxicity and gene expression modulation of histone deacetylase and DNA methyltransferase inhibitors were evaluated in both PDTC and ATC. Read More

J Neurosci 2018 Nov 30. Epub 2018 Nov 30.

Institut de Génétique et de Biologie Moléculaire et Cellulaire, 67400 Illkirch, France

Despite their different origins, glia and hemocytes are related cell populations that provide an immune function. hemocytes patrol the body cavity and act as macrophages outside the nervous system whereas glia originate from the neuroepithelium and provide the scavenger population of the nervous system. glia are hence the functional orthologs of vertebrate microglia, even though the latter are cells of immune origin that subsequently move into the brain during development. Read More

Curr Biol 2018 Nov 15. Epub 2018 Nov 15.

Wellcome Centre for Cell Biology and Institute of Cell Biology, School of Biological Sciences, The University of Edinburgh, Edinburgh EH9 3BF, UK. Electronic address:

Active centromeres are defined by the presence of nucleosomes containing CENP-A, a histone H3 variant, which alone is sufficient to direct kinetochore assembly. Once assembled at a location, CENP-A chromatin and kinetochores are maintained at that location through a positive feedback loop where kinetochore proteins recruited by CENP-A promote deposition of new CENP-A following replication. Although CENP-A chromatin itself is a heritable entity, it is normally associated with specific sequences. Read More

Cancer Lett 2018 Nov 29. Epub 2018 Nov 29.

Department of Radiotherapy & Oncology, Kunshan First People's Hospital Affiliated to Jiangsu University, Kunshan, China. Electronic address:

Advanced stage nasopharyngeal carcinoma (NPC) has a poor prognosis. Triptonide ("TN") is a small molecule monomer extract from the ancient Chinese herb Tripterygium wilfordii Hook. We show that TN, at nanomolar concentrations, potently inhibited survival and proliferation of multiple established and primary human NPC cells. Read More

Cell 2018 Nov 21. Epub 2018 Nov 21.

Department of Neurobiology, Stanford University School of Medicine, Stanford, CA 94305, USA.

Nervous system function depends on proper myelination for insulation and critical trophic support for axons. Myelination is tightly regulated spatially and temporally, but how it is controlled molecularly remains largely unknown. Here, we identified key molecular mechanisms governing the regional and temporal specificity of CNS myelination. Read More

Fertil Steril 2018 Dec;110(7):1328-1337

Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.

Objective: To evaluate the relationship between demographic, lifestyle, and reproductive factors and the risk of ectopic pregnancy (EP).

Design: Prospective cohort.

Setting: United States. Read More

Fertil Steril 2018 Dec;110(7):1265-1266

Professor of Obstetrics & Gynecology and Pathology, Stony Brook University Medical Center, Stony Brook, New York.

Hum Mol Genet 2018 Dec 4. Epub 2018 Dec 4.

Department of Pediatrics, University of Colorado School of Medicine; Aurora, CO, 80045; USA.

The microtubule cytoskeleton supports diverse cellular morphogenesis and migration processes during brain development. Mutations in tubulin genes are associated with severe human brain malformations known as 'tubulinopathies'; however, it is not understood how molecular-level changes in microtubule subunits lead to brain malformations. In this study, we demonstrate that missense mutations affecting arginine at position 402 (R402) of TUBA1A α-tubulin selectively impair dynein motor activity, and severely and dominantly disrupt cortical neuronal migration. Read More

Hum Reprod 2018 Dec 4. Epub 2018 Dec 4.

Reproductive Medicine Center, The First Affiliated Hospital, Sun Yat-Sen University, 58, Zhongshan Road II, Guangzhou, China.

Study Question: Do human embryos survive long-term cryopreservation (CP) (≥12 years) and implant after frozen embryo transfer (ET)?

Summary Answer: Human embryos remain usable after long-term CP.

What Is Known Already: Several cohort studies have reported the live birth rate or neonatal outcomes of human embryos after CP for up to 5 years. Only a few case reports have described successful live births from human embryos after long-term CP up to 12 years. Read More

J Cardiovasc Electrophysiol 2018 Dec 5. Epub 2018 Dec 5.

Cardiology Department, University of Tours, Tours, France.

Introduction: Ablation of premature ventricular contractions has emerged as a safe and effective treatment in patients experiencing a high premature ventricular contractions burden. Mapping of premature ventricular contractions origin may sometimes be challenging. We sought to evaluate the accuracy of a new electrophysiological criterion, the Distal-to-Proximal Delay, at localizing the optimal site for ablation of ventricular ectopic foci. Read More

Front Plant Sci 2018 20;9:1687. Epub 2018 Nov 20.

National Engineering Laboratory for Resource Development of Endangered Crude Drugs in Northwest of China, Key Laboratory of the Ministry of Education for Medicinal Resources and Natural Pharmaceutical Chemistry, Shaanxi Normal University, Xi'an, China.

Phenolic acids from have drawn considerable attention in recent years because of their remarkable pharmacological activities. We previously reported that transcription factor production of anthocyanin pigment 1 (AtPAP1) has strong capability to promote the production of phenolic acids in . However, the responsible molecular mechanism is unclear. Read More

J Exp Clin Cancer Res 2018 Dec 4;37(1):301. Epub 2018 Dec 4.

Department of Radiation Oncology, North China University of Science and Technology Affiliated People's Hospital, Shengli Road, Tangshan, 063000, China.

Background: Esophageal cancer is a high incident cancer worldwide with poor survival and limited therapeutic options. Alterations of microRNAs are common in cancers, and many of these micro RNAs are potential therapeutic and diagnostic targets to treat these cancers. miR-10b-3p located in chromosome region 2q31. Read More

Reprod Sci 2018 Dec 4:1933719118811643. Epub 2018 Dec 4.

1 Department of Gynecology and Obstetrics, University of Giessen, Giessen, Germany.

Claudins are the major components of tight junctions and are often deregulated in human cancer, permitting escape of cancer cells along with the acquisition of invasive properties. Similarly, endometrial cells also show invasive capabilities; however, the role of tight junctions in endometriosis has only rarely been examined. In this study, we analyzed the protein expression and localization of claudin-7 and claudin-11 in human eutopic and ectopic endometrium and endometrial cell lines. Read More

FASEB J 2018 Dec 4:fj201801695R. Epub 2018 Dec 4.

Xin Hua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China; and.

Intestinal villus atrophy is a major complication of total parenteral nutrition (TPN). Our previous study revealed that TPN-induced villus atrophy is accompanied by elevated expression of CUGBP, Elav-like family member 1 (CELF1); however, its mechanism of action has not been fully understood. Herein, we report a pivotal role of CELF1/p53 axis, which induces a sustained antiproliferative signal, leading to suppressed proliferation of intestinal epithelial cells (IECs). Read More

J Stomatol Oral Maxillofac Surg 2018 Dec 1. Epub 2018 Dec 1.

Department of Oral & ENT Pathology, Pitié-Salpêtrière Hospital, Department of Dermatology, Cochin-Port Royal Hospital, Paris France.

Introduction: Pleomorphic adenoma (PA) is the most common benign salivary gland tumor, frequently affecting the major salivary glands but also the palatal or labial minor salivary glands. Pleomorphic adenomas affecting the retromolar trigone have seldom been reported with only few cases described in the literature.

Observation: We present the case of a young female patient who presented with this rare localization of pleomorphic adenoma and its subsequent management. Read More

Osteoarthritis Cartilage 2018 Dec 1. Epub 2018 Dec 1.

Laboratory of Tissue Homeostasis and Disease, Skeletal Biology and Engineering Research Center, KU Leuven, Leuven, Belgium. Electronic address:

Objective: We earlier identified that the histone methyltransferase DOT1L is as a master protector of cartilage health via limiting excessive activation of the Wnt pathway. However, cartilage-specific homozygous Dot1l knockout mice exhibited a severe growth phenotype and perinatal death, which hampered their use in induced or ageing models of osteoarthritis (OA). The aim of this study was to generate and examine haploinsufficient and inducible conditional Dot1l-deficient mouse models to evaluate the importance of DOT1L during post-traumatic or ageing-associated OA onset and progression. Read More

Zhejiang Da Xue Xue Bao Yi Xue Ban 2018 Feb;47(4):419-425

Women's Hospital, Zhejiang University School of Medicine, Hangzhou 310006, China.

A large number of studies have shown that the oxidative imbalance is common in patients with endometriosis. Abnormal respiratory chain of mitochondrial, estrogen metabolism imbalance, iron overload, and ectopic foci may increase active oxygen, reduction of antioxidant enzyme and non-enzymatic substances may result in decreased antioxidant level, and the exposure to environmental hazards may further aggravate oxidative imbalance in patients with endometriosis. This article analyzes the oxidative imbalance and its role in the pathogenesis of endometriosis from the aspects of excessive oxide production and decreased antioxidant capacity. Read More

New Phytol 2018 Dec 3. Epub 2018 Dec 3.

GBF Laboratory, Université de Toulouse, INRA, Castanet-Tolosan, 31320, France.

Ethylene is the main hormone controlling climacteric fruit ripening; however, the mechanisms underlying the developmental transition leading to initiation of the ripening process remain elusive although the presumed role of active hormone interplay has been often postulated. To unravel the putative role of auxin in the unripe-to-ripe transition, we investigated the dynamics of auxin activity in tomato fruit and addressed the physiological significance of Sl-SAUR69, previously identified as RIN target gene, using reverse genetics approaches. Auxin signalling undergoes dramatic decline at the onset of ripening in wild type fruit but not in the nonripening rin mutant. Read More

J Cell Physiol 2018 Dec 3. Epub 2018 Dec 3.

Jiangsu Key Laboratory for Molecular and Medical Biotechnology, College of Life Sciences, Nanjing Normal University, Nanjing, China.

Maduramicin (Mad), a polyether ionophore antibiotic, has been reported to be toxic to animals and humans because of being used at high doses or for long time, resulting in heart failure. However, the toxic mechanism of Mad in cardiac muscle cells is not well understood. Here, we show that Mad induced cell viability reduction and apoptosis in cardiac-derived H9c2, HL-1 cells, primary cardiomyocytes, and murine cardiac muscles, which was because of the inhibition of extracellular-signal-regulated kinase 1/2 (Erk1/2). Read More

Int J Cancer 2018 Dec 3. Epub 2018 Dec 3.

Department of Urology, Zhongnan Hospital of Wuhan University, Wuhan, China.

Considering the importance of microRNAs (miRNAs) in regulating cellular processes, we performed microarray analysis and revealed miR-4324 as one of the most differentially expressed miRNAs in bladder cancer (BCa). Then, we discovered that miR-4324 was a negative regulator of Rac GTPase activating protein 1 (RACGAP1) and that RACGAP1 functioned as an oncogenic protein in BCa. Our studies indicated that ectopic overexpression of miR-4324 in BCa cells significantly suppressed cell proliferation and metastasis and enhanced chemotherapy sensitivity to doxorubicin by repressing RACGAP1 expression. Read More

Am J Clin Exp Urol 2018 20;6(5):172-181. Epub 2018 Oct 20.

Department of Biochemistry and Molecular Biology, LSU Health Sciences Center Shreveport, Louisiana 71103, USA.

Prostate cancer (PCa) is the leading cancer among men. Androgen Deprivation Therapy (ADT) is a common treatment for advanced PCa. However, ADT eventually fails and PCa relapses, developing into castration-resistant prostate cancer (CRPCa). Read More

World J Clin Cases 2018 Nov;6(14):791-799

Gastroenterology Service and Department of Internal Medicine, Faculty of Medicine, University Hospital "Dr. José E. González", Universidad Autónoma de Nuevo León, Monterrey 64700, Nuevo León, México.

Background: Meckel's diverticulum (MD) occurs predominantly in children and adolescents. It is rarely diagnosed in adults. Preoperative diagnosis is difficult due to low sensitivity of the radiological imaging studies. Read More

Cureus 2018 Sep 25;10(9):e3361. Epub 2018 Sep 25.

Neurosurgery, Seattle Science Foundation, Seattle, USA.

Endometriosis is a gynecological disorder identified by the presence of ectopic endometrial tissue outside the uterus. Largely, it affects reproductive-aged women and is a major cause of infertility. Clinical manifestations of endometriosis include dyspareunia, cyclic menstrual pain, chronic pelvic pain, and dyschezia, all of which can affect the patient's quality of life and health severely; therefore, it is paramount that medical treatment is initiated as soon as endometriosis is suspected clinically. Read More

Facts Views Vis Obgyn 2018 Mar;10(1):47-50

Sint-Jozef Kliniek, Department of gynecology and obstetrics, Kasteelstraat 23, 2880 Bornem, Belgium.

Undescended ovary is a rare congenital gynecologic condition, frequently associated with urogenital malformations including unicornuate uterus and ectopic kidneys or renal agenesis. Although ectopic ovaries are mostly found during an infertility work up, its role in infertility is still unknown. We report a 38-year-old patient presenting with pain in the right lower quadrant. Read More

Genetics 2018 Dec 3. Epub 2018 Dec 3.

University of Montana

Developmental transitions of germ cells are often regulated at the level of post-transcriptional control of gene expression. In the germline, stem and progenitor cells exit the proliferative phase and enter meiotic differentiation to form gametes essential for fertility. The RNA-binding protein GLD-1 is a cell fate regulator that promotes meiosis and germ cell differentiation during development by binding to and repressing translation of target mRNAs. Read More

BMC Plant Biol 2018 Dec 3;18(1):320. Epub 2018 Dec 3.

Institute of Crop Sciences, Chinese Academy of Agricultural Sciences (CAAS)/National Key Facility for Crop Gene Resources and Genetic Improvement, Key Laboratory of Biology and Genetic Improvement of Triticeae Crops, Ministry of Agriculture, Beijing, 100081, China.

Background: Abiotic stress severely influences plant growth and development. MYB transcription factors (TFs), which compose one of the largest TF families, play an important role in abiotic stress responses.

Result: We identified 139 soybean MYB-related genes; these genes were divided into six groups based on their conserved domain and were distributed among 20 chromosomes (Chrs). Read More

Neoplasma 2018 Sep 4. Epub 2018 Sep 4.

Department of General Surgery, the Fourth Affiliated Hospital, Hebei Medical University, Shijiazhuang, China.

Gastric cancer (GC) is a leading cause of global cancer-related death. The incidence and mortality rates of gastric cancer in China are second and third ranked in all forms of malignant tumors. Krüppel-like factor11 (KLF11) is a member of the KLF family, and previous studies have shown it significantly influences epithelial ovarian, pancreatic and liver cancer proliferation, differentiation and apoptosis. Read More

Medicine (Baltimore) 2018 Nov;97(48):e13143

Department of Interventional Radiology, The Second Affiliated Hospital of Nantong University.

To explore the effect of interventional embolization treatment for hydrosalpinx on the outcome of in vitro fertilization and embryo transfer (IVF-ET).During the period from January 2013 to January 2015, a total of 129 patients with unilateral or bilateral hydrosalpinx were treated with IVF-ET and selected for retrospective analysis. Seventy-three patients (intervention group) with unilateral or bilateral hydrosalpinx were treated with fallopian tube embolization, which was followed by IVF-ET. Read More

Reproduction 2018 Nov 1. Epub 2018 Nov 1.

L Zhang, Department of Obstetrics and Gynecology, Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Endometriosis is an estrogen-dependent benign gynecological disease that shares some common features of malignancy. Epithelial-mesenchymal transition (EMT) has been recognized as a core mechanism of endometriosis. MALAT1 is widely known as EMT promoter, while miR200 family members (miR200s) are considered as EMT inhibitors. Read More