1,191 results match your criteria Ecthyma Gangrenosum


Successful Use of Negative-pressure Wound Therapy and Dermal Substitute in the Treatment of Gluteal Ecthyma Gangrenosum in a 2-year-old Girl.

Plast Reconstr Surg Glob Open 2018 Oct 3;6(10):e1953. Epub 2018 Oct 3.

Department of Pediatric Surgery, Meyer Children Hospital, Florence, Italy.

Ecthyma Gangrenosum is a manifestation of infection, usually occurring in immunocompromised patients, which can be associated with bacteremia with potentially lethal outcome. The clinical appearance is of an inflammatory cutaneous lesion with a central necrotic spot; the lesion then rapidly progresses to a gangrenous ulcer with a gray-black eschar extending in the deep soft tissues. Treatment of Ecthyma Gangrenosum includes both aggressive systemic antibiotic therapy and surgical procedures. Read More

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October 2018

Septic shock related to community-acquired pneumonia with ecthyma gangrenosum.

Med Mal Infect 2018 Dec 7. Epub 2018 Dec 7.

Service de médecine intensive et de réanimation polyvalente, CHU de Reims, 51092 Reims, France.

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December 2018

Clinical Manifestation, Dermoscopy, and Scanning Electron Microscopy in Two Cases of Contagious Ecthyma (Orf Nodule).

Case Rep Dermatol Med 2018 29;2018:2094086. Epub 2018 Oct 29.

Dermatology Division, Department of Internal Medicine, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.

Orf is a highly contagious skin disease commonly seen in goats and sheep that can be transmitted to people who have direct contact with infected animals. Here, we report the clinical manifestation, dermoscopy, and scanning electron microscopy in two women who developed skin lesions on their hands after handling goats with wounds in the udders. Human orf is usually self-limiting and no specific treatment is needed. Read More

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October 2018
1 Read

First report of camel contagious ecthyma in Nigeria.

Open Vet J 2018 19;8(2):208-211. Epub 2018 Jun 19.

National Veterinary Research Institute, Vom, Nigeria.

Camel contagious ecthyma (CCE) is a viral disease of camelids that is caused by a Parapoxvirus (PPV) which is a DNA virus of the viral family: . Diseases affecting camels in Nigeria are scarcely reported. CCE or the laboratory detection of camel PPV (CPPV) has not been reported in Nigeria. Read More

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June 2018
1 Read

[Ecthyma gangrenosum].

Pan Afr Med J 2018 5;30:95. Epub 2018 Jun 5.

University Mohammed V, Ibn Sina, Hospital University, Rabat, Morocco.

Ecthyma gangrenosum (EG) is a severe potentially lethal cutaneous infection that progresses sequentially from maculopapular rash to haemorrhagic bulla and then to necrotic ulceration with surrounding erythema. It usually occurs in immunocompromised patients (aplasia secondary to chemotherapy, HIV infection, neutropenia or functional deficit of neutrophils, agammaglobulinemia). It rarely affects healthy people. Read More

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October 2018
7 Reads

Ecthyma Gangrenosum in Paroxysmal Nocturnal Hemoglobinuria.

Acta Haematol 2018 9;140(3):166-168. Epub 2018 Oct 9.

Department of Dermatology, Hospital Universitario de La Princesa, Madrid, Spain.

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October 2018
4 Reads

Primary ecthyma gangraenosum due to central venous catheter-related bloodstream infection with Pseudomonas aeruginosa.

Infection 2018 Sep 5. Epub 2018 Sep 5.

Department of Haematology and Oncology, Medical Centre, Otto-von-Guericke University Magdeburg, Leipziger Str. 44, 39120, Magdeburg, Germany.

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September 2018
1 Read

Detection and phylogenetic analysis of Orf virus in Kashmir Himalayas.

Virusdisease 2018 Sep 28;29(3):405-410. Epub 2018 Jul 28.

1Division of Veterinary Microbiology and Immunology, Faculty of Veterinary Sciences and Animal Husbandry (FVSc & AH), Sher-e-Kashmir University of Agricultural Sciences and Technology of Kashmir (SKUAST-K), Srinagar, 190006 India.

Orf virus (ORFV) is a zoonotic pathogen that primarily infects sheep and goats, and is responsible for significant economic losses. ORFV is endemic in all the major sheep and goat rearing areas of the world including Indian subcontinent. However, the nature of ORFV circulating among sheep and goat in Kashmir Himalayas has not yet been characterized. Read More

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September 2018
1 Read

Evaluation of a recombinant major envelope protein (F1L) based indirect- ELISA for sero-diagnosis of orf in sheep and goats.

J Virol Methods 2018 11 24;261:112-120. Epub 2018 Aug 24.

ICAR- National Institute of Veterinary Epidemiology and Disease Informatics (NIVEDI), Bengaluru, 560064, Karnataka, India.

Orf or contagious ecthyma, is a highly contagious transboundary disease of sheep and goats. For sero-diagnosis of orf, recombinant antigen based assays are considered as alternatives to conventional approaches such as serum neutralization test (SNT) and counter-immuno-electrophoresis (CIE). A major envelope protein of orf virus (ORFV), F1L, is highly immunogenic and is a candidate for use in these assays. Read More

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November 2018
13 Reads

Ecthyma gangrenosum due to Pseudomonas fluorescens.

Cutis 2018 Jul;102(1):E13-E15

Division of Dermatology, David Geffen School of Medicine at University of California, Los Angeles, USA.

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July 2018
10 Reads

Ecthyma contagiosum (Orf): Reflectance confocal microscopy and histopathological correlates.

Skin Res Technol 2018 Jul 18. Epub 2018 Jul 18.

Dermatology Division, Department of Medical, Surgical and NeuroSciences, University of Siena, Siena, Italy.

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July 2018
1 Read

Phylogenetic Analysis of ORF Viruses From Five Contagious Ecthyma Outbreaks in Argentinian Goats.

Front Vet Sci 2018 19;5:134. Epub 2018 Jun 19.

Instituto de Biotecnología, Centro Nacional de Investigaciones Agropecuarias, Instituto Nacional de Tecnología Agropecuaria, Consejo Nacional de Investigaciones Científicas y Técnicas, Buenos Aires, Argentina.

Orf virus (ORFV) is the etiological agent of Contagious Ecthyma (CE) disease that mainly affects sheep, goats, wild ruminants, and humans with a worldwide distribution. To date, only two strains from Argentinian sheep have been characterized at the molecular level and there is little information on ORFV strains circulating in Argentina. Here we describe and analyze five outbreaks of CE in goats in three geographic regions of the country: Northwest, Center, and Southwest. Read More

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June 2018
12 Reads

Molecular evidence and phylogenetic analysis of orf virus isolates from outbreaks in Tripura state of North-East India.

Virusdisease 2018 Jun 22;29(2):216-220. Epub 2018 Mar 22.

1Division of Virology, ICAR-Indian Veterinary Research Institute, Mukteswar, Nainital District, Uttarakhand 263 138 India.

This study describes the first confirmed report of contagious ecthyma in Black Bengal goats from Tripura state, a North-Eastern state of India situated at the Indo-Bangladesh border. Outbreaks were characterized by the high rates of morbidity (58-67%), low mortality (8-10%) and case fatality (11-15%). The etiology of the outbreaks was confirmed as orf virus (ORFV) by standard virological/serological and molecular techniques including sequence analysis of B2L, a major envelop protein gene of genus . Read More

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June 2018
9 Reads

Ecthyma Gangrenosum: Vulvar Ulcers, Pseudomonas, and Pancytopenia: A Case Report of an 18-Month-Old Female Toddler.

J Pediatr Adolesc Gynecol 2018 Dec 6;31(6):625-628. Epub 2018 Jun 6.

Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada; Children's Hospital of Eastern Ontario Research Institute, Ottawa, Ontario, Canada; Department of Obstetrics and Gynecology, University of Ottawa, Ottawa, Ontario, Canada; Ottawa Hospital Research Institute, Ottawa, Ontario, Canada; Division of Gynecology, Department of Surgery, Children's Hospital of Eastern Ontario, Ottawa, Ontario, Canada. Electronic address:

Background: An 18-month-old female toddler presented with severe vulvar ulcers and pancytopenia with investigations revealing Pseudomonas aeruginosa bacteremia.

Case: A previously healthy 18-month-old female toddler presented with 6 days of fevers, vulvar rash, and ulcers. Vulvar cultures showed Staphylococcus aureus and P aeruginosa. Read More

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December 2018
17 Reads

Non-pseudomonal Ecthyma Gangrenosum and Idiopathic Myelofibrosis in a Two-Year-Old Girl.

Cureus 2018 Apr 6;10(4):e2441. Epub 2018 Apr 6.

Department of Internal Medicine, Civil Hospital Karachi, Dow University of Health Sciences (DUHS), Karachi, PAK.

Ecthyma gangrenosum is a skin lesion consequent to bacteremia, mostly due to Pseudomonas aeruginosa, although it may develop secondary to other organisms as well. The disease is often witnessed in patients with leukemia; however, a few cases of ecthyma gangrenosum in adults were reported to be associated with myelofibrosis. We report a case of ecthyma gangrenosum due to Escherichia coli (E. Read More

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April 2018
6 Reads

Pathogenicity of blood orf virus isolates in the development of dairy goat contagious pustular dermatitis.

Vet Microbiol 2018 Jun 13;219:178-182. Epub 2018 Apr 13.

Veterinary Immunology Laboratory, College of Veterinary Medicine, Northwest Agriculture and Forestry University, Yangling 712100, Shaanxi Province, China. Electronic address:

Contagious pustular dermatitis is an exanthematous zoonotic disease caused by the orf virus. Pandemic outbreaks of this disease cause great economic losses, while the pathogenesis of this disease still remains obscure. In this study, blood samples were collected from 628 asymptomatic goats across China for PCR-based virus detection. Read More

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June 2018
3 Reads

Erythema multiforme after orf virus infection.

Pediatr Dermatol 2018 Jul 15;35(4):e237-e238. Epub 2018 May 15.

Department of Dermatology, Hospital Infantil Universitario Niño Jesús, Madrid, Spain.

The case of a 6-year-old boy with multiple, target-shaped lesions and a crusted nodule on his right index finger is presented. Based on clinical findings and the patient's recent contact with sheep and goats, a diagnosis of orf disease associated with erythema multiforme was suspected. Microscopy studies confirmed the presence of parapoxvirus in the primary lesion. Read More

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July 2018
2 Reads
1.520 Impact Factor

Poxvirus-Induced Vascular Angiogenesis Mimicking Pyogenic Granuloma.

Am J Dermatopathol 2018 Sep;40(9):e126-e129

Department of Dermatology, Bahçeşehir University Medical Faculty, Istanbul, Turkey.

The orf virus, a member of poxvirus family, is a zoonotic parapoxvirus endemic in many countries, mostly seen among sheep, goats, oxen, and may be transmitted to humans. Orf virus infections may induce ulceration, papulonodular, pustular, or ecthyma lesions in the skin. Rarely, orf virus provokes extensive vasculoendothelial proliferation by encoding an apparent homolog of the mammalian vascular endothelial growth factor family of molecules. Read More

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September 2018
11 Reads

[Orf virus in human, confirmation in case report from Chile].

Rev Chilena Infectol 2017 Dec;34(6):607-609

Facultad de Ciencias, Universidad Mayor, Santiago, Chile.

Infection with the orf virus, also known as contagious ecthyma, is recognized as an occupational zoonosis worldwide. It is diagnosed by cutaneous lesions that progress rapidly from macules to papules, vesicles and pustules. The clinical case of a student of veterinary medicine who had had contact with goats, clinically healthy and without apparent lesions, which occured 19 days ago, is reported. Read More

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December 2017
4 Reads

Orf virus infection in Alaskan mountain goats, Dall's sheep, muskoxen, caribou and Sitka black-tailed deer.

Acta Vet Scand 2018 Feb 21;60(1):12. Epub 2018 Feb 21.

Department of Nursing and Health Sciences-Vestfold, Faculty of Health and Social Sciences, University College of Southeast Norway, 3603, Kongsberg, Norway.

Background: The zoonotic Orf virus (ORFV; genus Parapoxvirus, Poxviridae family) occurs worldwide and is transmitted between sheep and goats, wildlife and man. Archived tissue samples from 16 Alaskan wildlife cases, representing mountain goat (Oreamnos americanus, n = 8), Dall's sheep (Ovis dalli dalli, n = 3), muskox (Ovibos moschatus, n = 3), Sitka black-tailed deer (Odocoileus hemionus sitkensis, n = 1) and caribou (Rangifer tarandus granti, n = 1), were analyzed.

Results: Clinical signs and pathology were most severe in mountain goats, affecting most mucocutaneous regions, including palpebrae, nares, lips, anus, prepuce or vulva, as well as coronary bands. Read More

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February 2018
12 Reads

Molekulare Diagnostik von Hautinfektionen am Paraffinmaterial - Übersicht und interdisziplinärer Konsensus.

J Dtsch Dermatol Ges 2018 Feb;16(2):139-148

Mikrobiologisches Institut - Klinische Mikrobiologie, Immunologie und Hygiene, Universitätsklinikum Erlangen und Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg.

Nukleinsäure-Amplifikations-Techniken (NAT), wie die PCR, sind hochsensitiv sowie selektiv und stellen in der mikrobiologischen Diagnostik wertvolle Ergänzungen zur kulturellen Anzucht und Serologie dar. Sie bergen aber gerade bei formalinfixiertem und in Paraffin eingebettetem Gewebe ein Risiko für sowohl falsch negative als auch falsch positive Resultate, welches nicht immer richtig eingeschätzt wird. Daher haben Vertreter der Deutschen Gesellschaft für Hygiene und Mikrobiologie (DGHM) und der Deutschen Dermatologischen Gesellschaft (DDG) einen Konsensus in Form einer Übersichtsarbeit erarbeitet, wann eine NAT am Paraffinschnitt angezeigt und sinnvoll ist und welche Punkte dabei in der Präanalytik und Befundinterpretation beachtet werden müssen. Read More

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February 2018
9 Reads

Molecular diagnosis of skin infections using paraffin-embedded tissue - review and interdisciplinary consensus.

J Dtsch Dermatol Ges 2018 Feb;16(2):139-147

Institute of Microbiology - Clinical Microbiology, Immunology, and Hygiene, University Medical Center and Friedrich Alexander University Erlangen-Nuremberg, Erlangen, Germany.

Nucleic acid amplification techniques (NATs), such as PCR, are highly sensitive and specific methods that have become valuable supplements to culture and serology in the diagnosis of infectious disorders. However, especially when using formalin-fixed and paraffin-embedded tissue, these techniques are associated with both false-negative and false-positive results, a pitfall that is frequently misjudged. Representatives of the German Society of Hygiene and Microbiology (DGHM) and the German Society of Dermatology (DDG) therefore set out to develop a consensus - in the form of a review article - on the appropriate indications for NATs using paraffin-embedded tissue, its contraindications, and the key points to be considered in the pre- and post-analytical phase. Read More

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February 2018
5 Reads

One Thing after Another: Ecthyma Gangrenosum.

Am J Med 2018 May 31;131(5):510-511. Epub 2018 Jan 31.

Chief of Infectious Diseases, Veterans Affairs Medical Center, Northport, NY; Stony Brook University School of Medicine, NY. Electronic address:

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May 2018
3 Reads

Genetic diversity of Orf virus isolated from sheep in Uruguay.

Arch Virol 2018 May 24;163(5):1285-1291. Epub 2018 Jan 24.

Sección Virología, Facultad de Ciencias, UdelaR, Iguá 4225, 11400, Montevideo, Uruguay.

Orf virus (ORFV) is the etiological agent of contagious ecthyma, a disease widely spread in the world that occasionally causes zoonotic infections. This work is the first molecular characterization of ORFV in Uruguay, where we analyzed twenty-one sheep samples, eighteen of which were recovered from thirteen ORFV outbreaks that occurred during 2004 to 2011 as well as three strains from a national vaccine. Phylogenetic analysis and the derived amino acid sequences from the B2L gene suggest that the Uruguayan virus do not form a unique cluster, with most of them displaying similarities with worldwide ORFV isolates as well as our vaccine strains. Read More

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May 2018
5 Reads

Photoletter to the editor: Atypical primary cutaneous mucormycosis of the scalp.

J Dermatol Case Rep 2017 Dec 1;11(2):32-34. Epub 2017 Dec 1.

Micology Department, General Hospital "Dr. Manuel Gea González", Mexico City, Mexico.

Mucormycosis of the scalp is a rare cutaneous presentation of the disease. It is also an unusual infection in children. We present the case of a 4-year-old girl with acute lymphoblastic leukemia, who presented with atypical cutaneous mucormycosis simulating an lesion. Read More

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December 2017
3 Reads

Estimating the proportion of clinically diagnosed infectious and non-infectious animal diseases in Ganta Afeshum woreda, Eastern Tigray zone, Ethiopia.

BMC Res Notes 2018 Jan 15;11(1):29. Epub 2018 Jan 15.

Department of Biomedical Sciences, College of Veterinary Medicine and Animal Sciences, The University of Gondar, P.O. Box: 196, Gondar, Ethiopia.

Objective: This study was performed with the objective of identifying the proportion of emerging and endemic livestock diseases using cross sectional survey.

Result: A total of 285 clinically diseased animals were presented to a veterinary clinic and diagnosed tentatively based on history, clinical sign, and simple laboratory diagnostics and from the study, actinomycosis (15.83%), mastitis (15%), tick infestation (10%), respiratory diseases (9. Read More

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January 2018
10 Reads

Molecular identification and investigations of contagious ecthyma (Orf virus) in small ruminants, North west Ethiopia.

BMC Vet Res 2018 Jan 15;14(1):13. Epub 2018 Jan 15.

Department of Clinical Studies, University of Gondar, College of Veterinary Medicine and Animal Sciences, P.O. Box: 196, Gondar, Ethiopia.

Background: Orf virus, the prototype of parapoxvirus, is the main causative agent of contagious ecthyma. Little is known about the status of the disease in Ethiopia and this study was aimed at determining its status using PCR as a confirmatory tool.

Methods: a total of 400 randomly selected sheep and goat was screened for the identification of the virus using amplification of B2L gene and transfection of mammalian cells (VERO cells). Read More

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January 2018
21 Reads

Orf (ecthyma contagiosum) in a sheep and a shepherd.

Lancet Infect Dis 2018 Jan 20;18(1):122. Epub 2017 Dec 20.

Department of Dermatology, Venereology and Allergology, University Medical Center Göttingen, Göttingen, Germany. Electronic address:

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January 2018
6 Reads

Clinical Guidelines for the Antibiotic Treatment for Community-Acquired Skin and Soft Tissue Infection.

Infect Chemother 2017 Dec;49(4):301-325

Department of Internal Medicine, Inje University Ilsan Paik Hospital, Goyang, Korea.

Skin and soft tissue infection (SSTI) is common and important infectious disease. This work represents an update to 2012 Korean guideline for SSTI. The present guideline was developed by the adaptation method. Read More

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December 2017
13 Reads

A parapoxviral virion protein targets the retinoblastoma protein to inhibit NF-κB signaling.

PLoS Pathog 2017 12 15;13(12):e1006779. Epub 2017 Dec 15.

Department of Pathobiology, College of Veterinary Medicine, University of Illinois at Urbana- Champaign, Urbana, IL, United States of America.

Poxviruses have evolved multiple strategies to subvert signaling by Nuclear Factor κB (NF-κB), a crucial regulator of host innate immune responses. Here, we describe an orf virus (ORFV) virion-associated protein, ORFV119, which inhibits NF-κB signaling very early in infection (≤ 30 min post infection). ORFV119 NF-κB inhibitory activity was found unimpaired upon translation inhibition, suggesting that virion ORFV119 alone is responsible for early interference in signaling. Read More

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December 2017
11 Reads

Rapidly Growing Nodule on the Finger of a 20-year-old Woman: A Quiz.

Acta Derm Venereol 2018 Apr;98(4):469-470

Department of Dermatology and Allergy, Technical University of Munich, Biedersteiner Str. 29, DE-80802 Munich, Germany.

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April 2018
11 Reads

[Multiple well demarcated skin erosions and ulcers following exanthematous drug eruption after sultamicillin therapy].

Hautarzt 2018 Jun;69(6):484-486

Klinik für Dermatologie, Venerologie und Allergologie, Universitätsklinikum Leipzig, Philipp-Rosenthal-Str. 23, 04103, Leipzig, Deutschland.

This article presents the case of a patient with newly developed skin erosions and ulcerations following an exanthematous drug eruption due to sultamicillin therapy. The skin lesions were treated topically with clobetasol and prednicarbate and orally with methylprednisolone. A skin smear revealed massive growth of Escherichia coli bacteria. Read More

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June 2018
19 Reads

Ecthyma Gangrenosum.

N Engl J Med 2017 Dec;377(23):e32

Sint Antonius Ziekenhuis, Nieuwegein, the Netherlands

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December 2017
5 Reads

Ecthyma gangrenosum: a report of eight cases.

An Bras Dermatol 2017 Sep-Oct;92(5):698-700

Department of Dermatology, University Hospital "Dr. José Eleuterio González", Universidad Autónoma de Nuevo León - Monterrey, México.

Ecthyma gangrenosum is a rare skin infection classically associated with Pseudomonas aeruginosa. We performed a retrospective study of all cases diagnosed with ecthyma gangrenosum from 2004-2010 in a university hospital in Mexico (8 cases, 5 female patients and 3 male patients, ages between 4 months and 2 years). The most common risk factor for ecthyma gangrenosum is neutropenia in immunocompromised patients. Read More

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February 2018
7 Reads

[A case of Orf disease complicated by erythema multiforme].

Authors:
M Maman Y Medhioub

Arch Pediatr 2017 Dec 16;24(12):1241-1243. Epub 2017 Nov 16.

Service d'accueil des urgences, American Memorial Hospital, CHU de Reims, 47, rue Cognacq-Jay, 51100 Reims, France.

Ecthyma contagiosum, or Orf, is a specific infection of small ruminants accidentally reaching humans. Few cases have been reported in the literature to date. We report here a case of ecthyma contagiosum occurred in a 9-year-old girl after contact with a flock of ecthyma sheep. Read More

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December 2017
1 Read

Tender edematous nodules on the hand.

Cutis 2017 Sep;100(3):148;158;166

Cooper Medical School, Rowan University, Camden, New Jersey, USA.

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September 2017
3 Reads

Ecthyma Gangrenosum in the Eyelid.

J Craniofac Surg 2018 03;29(2):531-532

Department of Oral and Maxillofacial Surgery, Virgen del Rocio University Hospital, Seville, Spain Department of Pathology, Virgen del Rocio University Hospital, Seville, Spain Department of Oral and Maxillofacial Surgery, Virgen del Rocio University Hospital, Seville, Spain.

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March 2018
2 Reads
0.680 Impact Factor

Transcriptome analysis of sheep oral mucosa response to Orf virus infection.

PLoS One 2017 26;12(10):e0186681. Epub 2017 Oct 26.

State Key Laboratory of Veterinary Etiological Biology, Key Laboratory of Veterinary Public Health of Ministry of Agriculture, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, Gansu, China.

Contagious ecthyma is a highly contagious disease with worldwide distribution, which is caused by the Orf virus (ORFV) belonging to the Parapoxvirus. To study the alteration of host gene expression in response to ORFV infection at the transcriptional level, several young small-tailed Han sheep were inoculated with ORFV, and their oral mucosa tissue samples (T0, T3, T7 and T15) were collected on day 0, 3, 7 and 15 after ORFV infection respectively. RNA-seq transcriptome comparisons were performed, showing that 1928, 3219 and 2646 differentially expressed genes (DEGs) were identified among T3 vs. Read More

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November 2017
9 Reads

Ecthyma gangrenosum, an important cutaneous infection to recognize in the immunosuppressed patient.

Clin Exp Dermatol 2018 Jan 23;43(1):67-69. Epub 2017 Oct 23.

Dermatology Department, Kingston Hospital NHS Foundation Trust, Galsworthy Road, Kingston upon Thames, London, UK.

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January 2018
2 Reads

Human orf: Atypical rash in an urban medical practice.

Can Fam Physician 2017 10;63(10):769-771

Instructor at Pharma-Medical Science College of Canada in Toronto.

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October 2017
2 Reads

Extensive orf infection in a toddler with associated id reaction.

Pediatr Dermatol 2017 Nov 21;34(6):e337-e340. Epub 2017 Sep 21.

Department of Pediatrics, School of Medicine, University of California, San Diego, San Diego, CA, USA.

Orf is a zoonotic parapoxvirus typically transmitted to humans by a bite from goats or sheep. We present an unusual case of multiple orf lesions on the fingers of a 13-month-old child who was bitten by a goat and subsequently developed progressive swelling, blistering, and necrotic papulonodules of the hand followed by an additional diffuse, pruritic, papular rash. A primary diagnosis of orf infection was confirmed using real-time polymerase chain reaction, and the diffuse eruption was clinically consistent with an id reaction. Read More

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November 2017
9 Reads

Disseminated sepsis as presenting diagnosis of X-linked agammaglobulinaemia in a previously well 16-month-old child.

BMJ Case Rep 2017 Aug 29;2017. Epub 2017 Aug 29.

Department of Pediatrics, All India Institute of Medical Sciences Jodphur, Jodhpur, Rajasthan, India.

We report a previously healthy 16-month-old child who presented to us with membranous pharyngitis and ecthyma gangrenosum. In this patient, was isolated from throat swab, cerebrospinal fluid, skin swab, urine, blood and synovial fluid in a single admission. In further workup, this child was diagnosed as a case of X-linked agammaglobulinaemia. Read More

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August 2017
10 Reads

Vasculopathies, cutaneous necrosis and emergency in dermatology.

G Ital Dermatol Venereol 2017 Dec 28;152(6):615-637. Epub 2017 Jul 28.

Department of Dermatology, de La Princesa University Hospital, Madrid, Spain.

Most emergencies in dermatology comprise a variety of entities with a usually benign course. However, vasculopathies and vasculitis are not common, but they could represent respectively 1.9% and 4. Read More

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December 2017
23 Reads

The whole genomic analysis of orf virus strain HN3/12 isolated from Henan province, central China.

BMC Vet Res 2017 Aug 18;13(1):260. Epub 2017 Aug 18.

Institute of Antibody Engineering, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou, 510515, People's Republic of China.

Background: The Orf virus (ORFV) is the causative agent of orf, a globally-occurring, acute, pustular, contagious disease affecting sheep, goats and humans with a worldwide distribution. Currently, the genomic analysis of four ORFV strains from the Fujian province in southern China and a NA1/11 strain isolated from the Jilin province in northeast China have been reported. However, little is known about the genomic information of ORFV strains from central China. Read More

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August 2017
8 Reads

A parapoxviral virion protein inhibits NF-κB signaling early in infection.

PLoS Pathog 2017 Aug 7;13(8):e1006561. Epub 2017 Aug 7.

Department of Pathobiology, College of Veterinary Medicine, University of Illinois at Urbana-Champaign, Urbana, Illinois, United States of America.

Poxviruses have evolved unique proteins and mechanisms to counteract the nuclear factor κB (NF-κB) signaling pathway, which is an essential regulatory pathway of host innate immune responses. Here, we describe a NF-κB inhibitory virion protein of orf virus (ORFV), ORFV073, which functions very early in infected cells. Infection with ORFV073 gene deletion virus (OV-IA82Δ073) led to increased accumulation of NF-κB essential modulator (NEMO), marked phosphorylation of IκB kinase (IKK) subunits IKKα and IKKβ, IκBα and NF-κB subunit p65 (NF-κB-p65), and to early nuclear translocation of NF-κB-p65 in virus-infected cells (≤ 30 min post infection). Read More

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August 2017
26 Reads

[Pseudomonas aeruginosa in dermatology].

Authors:
A Morand J-J Morand

Ann Dermatol Venereol 2017 Nov 2;144(11):666-675. Epub 2017 Aug 2.

Service de dermatologie, hôpital d'instruction des armées Sainte-Anne, 83800 Toulon, France. Electronic address:

Pseudomonas aeruginosa, a ubiquitous Gram-negative bacillus characterized by its greenish color and sweetish smell, is at the origin of potentially severe forms of dermatosis, such as ecthyma gangrenosum which marks immunosuppression or reveals blood-poisoning, especially in children. It frequently colonizes chronic wounds and serious burns, and spongiotic or acantholytic dermatosis, especially when severe or localized in skinfolds. It requires special care because of its high resistance to antibiotics and antiseptics. Read More

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November 2017
25 Reads

Non-pseudomonal ecthyma gangrenosum caused by methicillin-resistant S (MRSA) in a chronic alcoholic patient.

BMJ Case Rep 2017 Aug 3;2017. Epub 2017 Aug 3.

General Surgery, Sree Balaji Medical College and Hospital, Chennai, Tamil Nadu, India.

We report for the first time a case of non-pseudomonal ecthyma gangrenosum (EG) caused by methicillin-resistant in a chronic alcoholic without an associated immunocompromised state or disease. EG is an infection of the skin, commonly associated with bacteraemia, though other organisms are also known to be causally related. It usually occurs in patients who are terminally ill and the immunocompromised. Read More

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August 2017
8 Reads

Ecthyma gangrenosum caused by .

BMJ Case Rep 2017 Jul 27;2017. Epub 2017 Jul 27.

Department of Pulmonary and Critical Care, Brooke Army Medical Center, Fort Sam Houston, Texas, USA.

A 55-year-old man undergoing chemotherapy for recurrent multiple myeloma presented with a 2-day history of bilateral lower leg rash with pain and oedema. On examination, there were numerous non-palpable retiform pruritic patches over both lower legs. Skin pnch biopsy demonstrated a diffuse interstitial neutrophilic infiltrate with necrosis. Read More

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July 2017
2 Reads

Ecthyma gangrenosum as first manifestation of acute leukemia.

Med Clin (Barc) 2017 10 21;149(8):363. Epub 2017 Jul 21.

Servicio de Dermatología, Complejo Hospitalario Universitario de Pontevedra, EOXI Pontevedra-Salnés, Pontevedra, España.

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October 2017
4 Reads