1,207 results match your criteria Ecthyma


Ecthyma gangrenosum associated with bacteremia.

Proc (Bayl Univ Med Cent) 2018 Oct 20;31(4):528-529. Epub 2018 Sep 20.

Department of Internal Medicine, Scott & White Memorial HospitalTempleTexas.

Ecthyma gangrenosum is an exceedingly rare dermatologic complication of bacteremia or fungemia in immunocompromised patients. The lesions may be single or multiple and may occur anywhere on the body. We present a case of ecthyma gangrenosum with atypical organisms and risk factors resulting in delayed diagnosis of both the condition and the underlying infectious process that caused it. Read More

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https://www.tandfonline.com/doi/full/10.1080/08998280.2018.1
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http://dx.doi.org/10.1080/08998280.2018.1488493DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413986PMC
October 2018
3 Reads

Utility of platelet rich fibrin gel therapy in nonhealing ulcer secondary to ecthyma gangrenosum.

Dermatol Ther 2019 Apr 3:e12887. Epub 2019 Apr 3.

Department of Dermatology, Venereology & Leprology, All India Institute of Medical Sciences, Jodhpur, India.

Platelet rich fibrin (PRF) gel is a new second generation platelet concentrate, which has been widely used in various dermatological conditions such as nonhealing diabetic foot ulcers, venous ulcers, and trophic ulcers in leprosy. In this case report, we present a patient with nonhealing ulcer secondary to ecthyma gangrenosum, who showed dramatic response with PRF gel. This case suggests a role of PRF gel in nonhealing ulcers of infectious etiology which has not been described in English language literature. Read More

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http://dx.doi.org/10.1111/dth.12887DOI Listing
April 2019
2 Reads

Gram-negative cutaneous infections with unique filamentous forms.

J Cutan Pathol 2019 Mar 9. Epub 2019 Mar 9.

Department of Dermatology, New York-Presbyterian Hospital/Weill Cornell Medical Center, New York City, New York.

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http://dx.doi.org/10.1111/cup.13453DOI Listing

Outbreak of contagious ecthyma caused by Orf virus (Parapoxvirus ovis) in a vaccinated sheep flock in Uruguay.

Braz J Microbiol 2019 Mar 5. Epub 2019 Mar 5.

Plataforma de Investigación en Salud Animal, Instituto Nacional de Investigación Agropecuaria (INIA), Ruta 50 Km 11, La Estanzuela, Colonia, Uruguay.

Orf virus (ORFV) causes contagious ecthyma (CE), a highly transmissible, zoonotic disease of small ruminants. CE most commonly affects lambs and unvaccinated sheep. This work reports epidemiologic, clinicopathologic, and virologic findings in a CE outbreak in a vaccinated sheep flock in Uruguay and failure to detect ORFV in a commercial vaccine. Read More

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http://dx.doi.org/10.1007/s42770-019-00057-7DOI Listing
March 2019
1 Read

Fatal Oculocutaneous Ecthyma Gangrenosum in Human Immunodeficiency Virus/Acquired Immunodeficiency Syndrome: Case Report and Review of the Literature.

J Glob Infect Dis 2019 Jan-Mar;11(1):43-46

Department of Internal Medicine, University of Calabar, Calabar, Cross River State, Nigeria.

Ecthyma gangrenosum (EG) is a rare, infective skin disease, predominantly but not exclusively caused by . It is often seen in individuals with immunosuppression, although it has also been reported among previously healthy individuals. It was initially thought to be pathognomonic of septicemia, but this assertion was discarded following several reports on EG without bacteremia and EG with varied bacterial and fungal etiologies. Read More

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http://dx.doi.org/10.4103/jgid.jgid_54_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380104PMC
March 2019
5 Reads

Reliability and accuracy of smartphones for paediatric infectious disease consultations for children with rash in the paediatric emergency department.

BMC Pediatr 2019 Jan 31;19(1):40. Epub 2019 Jan 31.

Department of Pediatric Emergency Department, Dr. Behçet Uz Children's Hospital, İzmir, Turkey.

Objective: Smartphones and associated messaging applications have become the most common means of communication among health care workers and the general population. The aim of this study was to evaluate the reliability and accuracy of smartphones for the diagnosis of rash in children admitted to emergency departments during the night shift.

Methods: The images of the children who were admitted to the paediatric emergency department with rash were included in this study, and at least two images taken with smartphones by residents or paediatric infectious disease fellows were re-directed to the chief consultant of the Paediatric-Infectious Department via smartphone. Read More

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http://dx.doi.org/10.1186/s12887-019-1416-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354364PMC
January 2019
3 Reads

Orf virus (ORFV) infection in a three-dimensional human skin model: Characteristic cellular alterations and interference with keratinocyte differentiation.

PLoS One 2019 30;14(1):e0210504. Epub 2019 Jan 30.

Institute of Immunology/Molecular Pathogenesis, Center for Biotechnology and Biomedicine, College of Veterinary Medicine, University of Leipzig, Leipzig, Germany.

ORF virus (ORFV) is the causative agent of contagious ecthyma, a pustular dermatitis of small ruminants and humans. Even though the development of lesions caused by ORFV was extensively studied in animals, only limited knowledge exists about the lesion development in human skin. The aim of the present study was to evaluate a three-dimensional (3D) organotypic culture (OTC) as a human skin model for ORFV infection considering lesion development, replication of the virus, viral gene transcription and modulation of differentiation of human keratinocytes by ORFV. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0210504PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6353139PMC
January 2019
4 Reads

Hairy cell leukemia presenting with Ecthyma Gangrenosum- a case report.

BMC Infect Dis 2019 Jan 25;19(1):85. Epub 2019 Jan 25.

Department of Internal Medicine, St Antonius Hospital, Nieuwegein/ Utrecht, Koekoekslaan 1, 3435, CM, Nieuwegein, The Netherlands.

Background: Ecthyma gangrenosum is a cutaneous infectious usually associated with P. aeruginosa. It usually develops In patients with an underlying immunodeficiency. Read More

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http://dx.doi.org/10.1186/s12879-018-3644-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346580PMC
January 2019
2 Reads

Juvenile ecthyma gangrenosum caused by Pseudomonas aeruginosa revealing an underlying neutropenia: case report and review of the literature.

J Eur Acad Dermatol Venereol 2019 Apr 5;33(4):781-785. Epub 2019 Mar 5.

Department of Dermatology, University Hospital Antwerp (UZA), University of Antwerp (UA), Antwerp, Belgium.

Background: Ecthyma gangrenosum (EG) is characterized by the occurrence of erythematous, violaceous or haemorrhagic macules and/or vesicles, often evolving into necrotic ulcers, with a central grey-black eschar. It is a rare skin condition, usually occurring in immunocompromised patients suffering from bacterial sepsis caused by Pseudomonas aeruginosa. However, seemingly healthy children have been diagnosed with this skin disease as well. Read More

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http://dx.doi.org/10.1111/jdv.15420DOI Listing
April 2019
4 Reads

Comparison of the sensitivity of three cell cultures to ORFV.

BMC Vet Res 2019 Jan 7;15(1):13. Epub 2019 Jan 7.

State Key Laboratory of Veterinary Etiological Biology, Lanzhou Veterinary Research Institute, Chinese Academy of Agriculture Science, Lanzhou, 730046, China.

Background: Contagious ecthyma (CE) appears in the countries and regions containing goat and sheep farms, and it is considered a global epidemic. CE not only severely endangers the healthy development of the sheep and goat industries but also threatens human health. For viral infectious diseases, fast and effective isolation and culture of the pathogen is critical for CE diagnosis, and for disease prevention and control. Read More

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http://dx.doi.org/10.1186/s12917-018-1760-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322270PMC
January 2019
7 Reads

Ecthyma gangrenosum on the face of a malnourished child with sepsis: Simulating Cancrum oris.

Afr J Lab Med 2018 5;7(1):756. Epub 2018 Dec 5.

Department of Paediatrics, Usmanu Danfodiyo University Teaching Hospital, Sokoto, Nigeria.

Introduction: Ecthyma gangrenosum (EG) is a cutaneous lesion commonly caused by that involves mainly the lower limbs and gluteal region, seen more in immunosuppressed patients with neutropenia. Cancrum oris (Noma) is a gangrenous necrosis of the face that begins as a gingival ulcer and progresses rapidly to destroy contiguous tissues in malnourished children.

Case Presentation: This article reports a case of facial EG which was similar to Noma in a malnourished child: a 16-month old girl with fever, cough, weight loss, watery stool and swelling on right cheek. Read More

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http://www.ajlmonline.org/index.php/AJLM/article/view/756
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http://dx.doi.org/10.4102/ajlm.v7i1.756DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6295829PMC
December 2018
23 Reads

Concomitant diagnosis of immune deficiency and sepsis in a 19 month old with ecthyma gangrenosum by host whole-genome sequencing.

Cold Spring Harb Mol Case Stud 2018 Dec 17;4(6). Epub 2018 Dec 17.

Division of Infectious Disease, Department of Pediatrics, UCSD, San Diego, California 92093, USA.

X-linked agammaglobulinemia (XLA, OMIM#300300) is a rare monogenic primary immunodeficiency caused by mutations in the Bruton tyrosine kinase () gene. XLA is characterized by insufficient immunoglobulin levels and susceptibility to life-threatening bacterial infections. We report on a patient that presented with ecthyma gangrenosum and septicemia. Read More

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http://dx.doi.org/10.1101/mcs.a003244DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6318772PMC
December 2018
3 Reads

Successful Use of Negative-pressure Wound Therapy and Dermal Substitute in the Treatment of Gluteal Ecthyma Gangrenosum in a 2-year-old Girl.

Plast Reconstr Surg Glob Open 2018 Oct 3;6(10):e1953. Epub 2018 Oct 3.

Department of Pediatric Surgery, Meyer Children Hospital, Florence, Italy.

Ecthyma Gangrenosum is a manifestation of infection, usually occurring in immunocompromised patients, which can be associated with bacteremia with potentially lethal outcome. The clinical appearance is of an inflammatory cutaneous lesion with a central necrotic spot; the lesion then rapidly progresses to a gangrenous ulcer with a gray-black eschar extending in the deep soft tissues. Treatment of Ecthyma Gangrenosum includes both aggressive systemic antibiotic therapy and surgical procedures. Read More

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http://Insights.ovid.com/crossref?an=01720096-201810000-0003
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http://dx.doi.org/10.1097/GOX.0000000000001953DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6250464PMC
October 2018
7 Reads

Septic shock related to community-acquired pneumonia with ecthyma gangrenosum.

Med Mal Infect 2018 Dec 7. Epub 2018 Dec 7.

Service de médecine intensive et de réanimation polyvalente, CHU de Reims, 51092 Reims, France.

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http://dx.doi.org/10.1016/j.medmal.2018.11.010DOI Listing
December 2018
2 Reads

Clinical Manifestation, Dermoscopy, and Scanning Electron Microscopy in Two Cases of Contagious Ecthyma (Orf Nodule).

Case Rep Dermatol Med 2018 29;2018:2094086. Epub 2018 Oct 29.

Dermatology Division, Department of Internal Medicine, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.

Orf is a highly contagious skin disease commonly seen in goats and sheep that can be transmitted to people who have direct contact with infected animals. Here, we report the clinical manifestation, dermoscopy, and scanning electron microscopy in two women who developed skin lesions on their hands after handling goats with wounds in the udders. Human orf is usually self-limiting and no specific treatment is needed. Read More

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http://dx.doi.org/10.1155/2018/2094086DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6231385PMC
October 2018
4 Reads

First report of camel contagious ecthyma in Nigeria.

Open Vet J 2018 19;8(2):208-211. Epub 2018 Jun 19.

National Veterinary Research Institute, Vom, Nigeria.

Camel contagious ecthyma (CCE) is a viral disease of camelids that is caused by a Parapoxvirus (PPV) which is a DNA virus of the viral family: . Diseases affecting camels in Nigeria are scarcely reported. CCE or the laboratory detection of camel PPV (CPPV) has not been reported in Nigeria. Read More

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http://dx.doi.org/10.4314/ovj.v8i2.16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6202667PMC
June 2018
3 Reads

[Ecthyma gangrenosum].

Pan Afr Med J 2018 5;30:95. Epub 2018 Jun 5.

University Mohammed V, Ibn Sina, Hospital University, Rabat, Morocco.

Ecthyma gangrenosum (EG) is a severe potentially lethal cutaneous infection that progresses sequentially from maculopapular rash to haemorrhagic bulla and then to necrotic ulceration with surrounding erythema. It usually occurs in immunocompromised patients (aplasia secondary to chemotherapy, HIV infection, neutropenia or functional deficit of neutrophils, agammaglobulinemia). It rarely affects healthy people. Read More

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http://www.panafrican-med-journal.com/content/article/30/95/
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http://dx.doi.org/10.11604/pamj.2018.30.95.6244DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6191256PMC
October 2018
9 Reads

Ecthyma Gangrenosum in Paroxysmal Nocturnal Hemoglobinuria.

Acta Haematol 2018 9;140(3):166-168. Epub 2018 Oct 9.

Department of Dermatology, Hospital Universitario de La Princesa, Madrid, Spain.

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https://www.karger.com/Article/FullText/492739
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http://dx.doi.org/10.1159/000492739DOI Listing
October 2018
18 Reads

Primary ecthyma gangraenosum due to central venous catheter-related bloodstream infection with Pseudomonas aeruginosa.

Infection 2019 Apr 5;47(2):333-334. Epub 2018 Sep 5.

Department of Haematology and Oncology, Medical Centre, Otto-von-Guericke University Magdeburg, Leipziger Str. 44, 39120, Magdeburg, Germany.

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http://dx.doi.org/10.1007/s15010-018-1207-4DOI Listing
April 2019
7 Reads

Detection and phylogenetic analysis of Orf virus in Kashmir Himalayas.

Virusdisease 2018 Sep 28;29(3):405-410. Epub 2018 Jul 28.

1Division of Veterinary Microbiology and Immunology, Faculty of Veterinary Sciences and Animal Husbandry (FVSc & AH), Sher-e-Kashmir University of Agricultural Sciences and Technology of Kashmir (SKUAST-K), Srinagar, 190006 India.

Orf virus (ORFV) is a zoonotic pathogen that primarily infects sheep and goats, and is responsible for significant economic losses. ORFV is endemic in all the major sheep and goat rearing areas of the world including Indian subcontinent. However, the nature of ORFV circulating among sheep and goat in Kashmir Himalayas has not yet been characterized. Read More

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http://dx.doi.org/10.1007/s13337-018-0473-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6111950PMC
September 2018
3 Reads

Evaluation of a recombinant major envelope protein (F1L) based indirect- ELISA for sero-diagnosis of orf in sheep and goats.

J Virol Methods 2018 11 24;261:112-120. Epub 2018 Aug 24.

ICAR- National Institute of Veterinary Epidemiology and Disease Informatics (NIVEDI), Bengaluru, 560064, Karnataka, India.

Orf or contagious ecthyma, is a highly contagious transboundary disease of sheep and goats. For sero-diagnosis of orf, recombinant antigen based assays are considered as alternatives to conventional approaches such as serum neutralization test (SNT) and counter-immuno-electrophoresis (CIE). A major envelope protein of orf virus (ORFV), F1L, is highly immunogenic and is a candidate for use in these assays. Read More

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http://dx.doi.org/10.1016/j.jviromet.2018.08.015DOI Listing
November 2018
18 Reads
1.883 Impact Factor

Ecthyma gangrenosum due to Pseudomonas fluorescens.

Cutis 2018 Jul;102(1):E13-E15

Division of Dermatology, David Geffen School of Medicine at University of California, Los Angeles, USA.

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July 2018
13 Reads

Ecthyma contagiosum (Orf): Reflectance confocal microscopy and histopathological correlates.

Skin Res Technol 2019 Mar 18;25(2):234-237. Epub 2018 Jul 18.

Dermatology Division, Department of Medical, Surgical and NeuroSciences, University of Siena, Siena, Italy.

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http://dx.doi.org/10.1111/srt.12618DOI Listing
March 2019
2 Reads

Phylogenetic Analysis of ORF Viruses From Five Contagious Ecthyma Outbreaks in Argentinian Goats.

Front Vet Sci 2018 19;5:134. Epub 2018 Jun 19.

Instituto de Biotecnología, Centro Nacional de Investigaciones Agropecuarias, Instituto Nacional de Tecnología Agropecuaria, Consejo Nacional de Investigaciones Científicas y Técnicas, Buenos Aires, Argentina.

Orf virus (ORFV) is the etiological agent of Contagious Ecthyma (CE) disease that mainly affects sheep, goats, wild ruminants, and humans with a worldwide distribution. To date, only two strains from Argentinian sheep have been characterized at the molecular level and there is little information on ORFV strains circulating in Argentina. Here we describe and analyze five outbreaks of CE in goats in three geographic regions of the country: Northwest, Center, and Southwest. Read More

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http://dx.doi.org/10.3389/fvets.2018.00134DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6018470PMC
June 2018
13 Reads

Molecular evidence and phylogenetic analysis of orf virus isolates from outbreaks in Tripura state of North-East India.

Virusdisease 2018 Jun 22;29(2):216-220. Epub 2018 Mar 22.

1Division of Virology, ICAR-Indian Veterinary Research Institute, Mukteswar, Nainital District, Uttarakhand 263 138 India.

This study describes the first confirmed report of contagious ecthyma in Black Bengal goats from Tripura state, a North-Eastern state of India situated at the Indo-Bangladesh border. Outbreaks were characterized by the high rates of morbidity (58-67%), low mortality (8-10%) and case fatality (11-15%). The etiology of the outbreaks was confirmed as orf virus (ORFV) by standard virological/serological and molecular techniques including sequence analysis of B2L, a major envelop protein gene of genus . Read More

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http://dx.doi.org/10.1007/s13337-018-0442-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6003057PMC
June 2018
10 Reads

Ecthyma Gangrenosum: Vulvar Ulcers, Pseudomonas, and Pancytopenia: A Case Report of an 18-Month-Old Female Toddler.

J Pediatr Adolesc Gynecol 2018 Dec 6;31(6):625-628. Epub 2018 Jun 6.

Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada; Children's Hospital of Eastern Ontario Research Institute, Ottawa, Ontario, Canada; Department of Obstetrics and Gynecology, University of Ottawa, Ottawa, Ontario, Canada; Ottawa Hospital Research Institute, Ottawa, Ontario, Canada; Division of Gynecology, Department of Surgery, Children's Hospital of Eastern Ontario, Ottawa, Ontario, Canada. Electronic address:

Background: An 18-month-old female toddler presented with severe vulvar ulcers and pancytopenia with investigations revealing Pseudomonas aeruginosa bacteremia.

Case: A previously healthy 18-month-old female toddler presented with 6 days of fevers, vulvar rash, and ulcers. Vulvar cultures showed Staphylococcus aureus and P aeruginosa. Read More

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http://dx.doi.org/10.1016/j.jpag.2018.05.007DOI Listing
December 2018
29 Reads

Non-pseudomonal Ecthyma Gangrenosum and Idiopathic Myelofibrosis in a Two-Year-Old Girl.

Cureus 2018 Apr 6;10(4):e2441. Epub 2018 Apr 6.

Department of Internal Medicine, Civil Hospital Karachi, Dow University of Health Sciences (DUHS), Karachi, PAK.

Ecthyma gangrenosum is a skin lesion consequent to bacteremia, mostly due to Pseudomonas aeruginosa, although it may develop secondary to other organisms as well. The disease is often witnessed in patients with leukemia; however, a few cases of ecthyma gangrenosum in adults were reported to be associated with myelofibrosis. We report a case of ecthyma gangrenosum due to Escherichia coli (E. Read More

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http://dx.doi.org/10.7759/cureus.2441DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5990025PMC
April 2018
8 Reads

Pathogenicity of blood orf virus isolates in the development of dairy goat contagious pustular dermatitis.

Vet Microbiol 2018 Jun 13;219:178-182. Epub 2018 Apr 13.

Veterinary Immunology Laboratory, College of Veterinary Medicine, Northwest Agriculture and Forestry University, Yangling 712100, Shaanxi Province, China. Electronic address:

Contagious pustular dermatitis is an exanthematous zoonotic disease caused by the orf virus. Pandemic outbreaks of this disease cause great economic losses, while the pathogenesis of this disease still remains obscure. In this study, blood samples were collected from 628 asymptomatic goats across China for PCR-based virus detection. Read More

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http://dx.doi.org/10.1016/j.vetmic.2018.04.020DOI Listing
June 2018
5 Reads

Erythema multiforme after orf virus infection.

Pediatr Dermatol 2018 Jul 15;35(4):e237-e238. Epub 2018 May 15.

Department of Dermatology, Hospital Infantil Universitario Niño Jesús, Madrid, Spain.

The case of a 6-year-old boy with multiple, target-shaped lesions and a crusted nodule on his right index finger is presented. Based on clinical findings and the patient's recent contact with sheep and goats, a diagnosis of orf disease associated with erythema multiforme was suspected. Microscopy studies confirmed the presence of parapoxvirus in the primary lesion. Read More

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http://dx.doi.org/10.1111/pde.13526DOI Listing
July 2018
3 Reads
1.520 Impact Factor

The re-emerging of orf virus infection: A call for surveillance, vaccination and effective control measures.

Microb Pathog 2018 Jul 28;120:55-63. Epub 2018 Apr 28.

Virology Unit, Department of Pathology and Microbiology, Faculty of Veterinary Medicine, University Putra Malaysia, Malaysia, 43400 Serdang, Selangor Darul Ehsan, Malaysia. Electronic address:

Orf disease is known to be enzootic among small ruminants in Asia, Africa, and some other parts of the world. The disease caused by orf virus is highly contagious among small ruminant species. Unfortunately, it has been neglected for decades because of the general belief that it only causes a self-limiting disease. Read More

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http://dx.doi.org/10.1016/j.micpath.2018.04.057DOI Listing
July 2018
8 Reads
1 Citation
2.000 Impact Factor

Poxvirus-Induced Vascular Angiogenesis Mimicking Pyogenic Granuloma.

Am J Dermatopathol 2018 Sep;40(9):e126-e129

Department of Dermatology, Bahçeşehir University Medical Faculty, Istanbul, Turkey.

The orf virus, a member of poxvirus family, is a zoonotic parapoxvirus endemic in many countries, mostly seen among sheep, goats, oxen, and may be transmitted to humans. Orf virus infections may induce ulceration, papulonodular, pustular, or ecthyma lesions in the skin. Rarely, orf virus provokes extensive vasculoendothelial proliferation by encoding an apparent homolog of the mammalian vascular endothelial growth factor family of molecules. Read More

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http://dx.doi.org/10.1097/DAD.0000000000001138DOI Listing
September 2018
14 Reads

[Orf med systemisk reaktion].

Ugeskr Laeger 2018 Feb;180(6)

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February 2018
3 Reads

[Orf virus in human, confirmation in case report from Chile].

Rev Chilena Infectol 2017 Dec;34(6):607-609

Facultad de Ciencias, Universidad Mayor, Santiago, Chile.

Infection with the orf virus, also known as contagious ecthyma, is recognized as an occupational zoonosis worldwide. It is diagnosed by cutaneous lesions that progress rapidly from macules to papules, vesicles and pustules. The clinical case of a student of veterinary medicine who had had contact with goats, clinically healthy and without apparent lesions, which occured 19 days ago, is reported. Read More

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http://dx.doi.org/10.4067/S0716-10182017000600607DOI Listing
December 2017
7 Reads

Orf virus infection in Alaskan mountain goats, Dall's sheep, muskoxen, caribou and Sitka black-tailed deer.

Acta Vet Scand 2018 Feb 21;60(1):12. Epub 2018 Feb 21.

Department of Nursing and Health Sciences-Vestfold, Faculty of Health and Social Sciences, University College of Southeast Norway, 3603, Kongsberg, Norway.

Background: The zoonotic Orf virus (ORFV; genus Parapoxvirus, Poxviridae family) occurs worldwide and is transmitted between sheep and goats, wildlife and man. Archived tissue samples from 16 Alaskan wildlife cases, representing mountain goat (Oreamnos americanus, n = 8), Dall's sheep (Ovis dalli dalli, n = 3), muskox (Ovibos moschatus, n = 3), Sitka black-tailed deer (Odocoileus hemionus sitkensis, n = 1) and caribou (Rangifer tarandus granti, n = 1), were analyzed.

Results: Clinical signs and pathology were most severe in mountain goats, affecting most mucocutaneous regions, including palpebrae, nares, lips, anus, prepuce or vulva, as well as coronary bands. Read More

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http://dx.doi.org/10.1186/s13028-018-0366-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5822636PMC
February 2018
16 Reads

Molekulare Diagnostik von Hautinfektionen am Paraffinmaterial - Übersicht und interdisziplinärer Konsensus.

J Dtsch Dermatol Ges 2018 Feb;16(2):139-148

Mikrobiologisches Institut - Klinische Mikrobiologie, Immunologie und Hygiene, Universitätsklinikum Erlangen und Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg.

Nukleinsäure-Amplifikations-Techniken (NAT), wie die PCR, sind hochsensitiv sowie selektiv und stellen in der mikrobiologischen Diagnostik wertvolle Ergänzungen zur kulturellen Anzucht und Serologie dar. Sie bergen aber gerade bei formalinfixiertem und in Paraffin eingebettetem Gewebe ein Risiko für sowohl falsch negative als auch falsch positive Resultate, welches nicht immer richtig eingeschätzt wird. Daher haben Vertreter der Deutschen Gesellschaft für Hygiene und Mikrobiologie (DGHM) und der Deutschen Dermatologischen Gesellschaft (DDG) einen Konsensus in Form einer Übersichtsarbeit erarbeitet, wann eine NAT am Paraffinschnitt angezeigt und sinnvoll ist und welche Punkte dabei in der Präanalytik und Befundinterpretation beachtet werden müssen. Read More

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http://dx.doi.org/10.1111/ddg.13438_gDOI Listing
February 2018
15 Reads

Molecular diagnosis of skin infections using paraffin-embedded tissue - review and interdisciplinary consensus.

J Dtsch Dermatol Ges 2018 Feb;16(2):139-147

Institute of Microbiology - Clinical Microbiology, Immunology, and Hygiene, University Medical Center and Friedrich Alexander University Erlangen-Nuremberg, Erlangen, Germany.

Nucleic acid amplification techniques (NATs), such as PCR, are highly sensitive and specific methods that have become valuable supplements to culture and serology in the diagnosis of infectious disorders. However, especially when using formalin-fixed and paraffin-embedded tissue, these techniques are associated with both false-negative and false-positive results, a pitfall that is frequently misjudged. Representatives of the German Society of Hygiene and Microbiology (DGHM) and the German Society of Dermatology (DDG) therefore set out to develop a consensus - in the form of a review article - on the appropriate indications for NATs using paraffin-embedded tissue, its contraindications, and the key points to be considered in the pre- and post-analytical phase. Read More

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http://dx.doi.org/10.1111/ddg.13438DOI Listing
February 2018
11 Reads

One Thing after Another: Ecthyma Gangrenosum.

Am J Med 2018 May 31;131(5):510-511. Epub 2018 Jan 31.

Chief of Infectious Diseases, Veterans Affairs Medical Center, Northport, NY; Stony Brook University School of Medicine, NY. Electronic address:

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http://dx.doi.org/10.1016/j.amjmed.2017.12.038DOI Listing
May 2018
5 Reads

Genetic diversity of Orf virus isolated from sheep in Uruguay.

Arch Virol 2018 May 24;163(5):1285-1291. Epub 2018 Jan 24.

Sección Virología, Facultad de Ciencias, UdelaR, Iguá 4225, 11400, Montevideo, Uruguay.

Orf virus (ORFV) is the etiological agent of contagious ecthyma, a disease widely spread in the world that occasionally causes zoonotic infections. This work is the first molecular characterization of ORFV in Uruguay, where we analyzed twenty-one sheep samples, eighteen of which were recovered from thirteen ORFV outbreaks that occurred during 2004 to 2011 as well as three strains from a national vaccine. Phylogenetic analysis and the derived amino acid sequences from the B2L gene suggest that the Uruguayan virus do not form a unique cluster, with most of them displaying similarities with worldwide ORFV isolates as well as our vaccine strains. Read More

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http://dx.doi.org/10.1007/s00705-018-3717-xDOI Listing
May 2018
7 Reads

Photoletter to the editor: Atypical primary cutaneous mucormycosis of the scalp.

J Dermatol Case Rep 2017 Dec 1;11(2):32-34. Epub 2017 Dec 1.

Micology Department, General Hospital "Dr. Manuel Gea González", Mexico City, Mexico.

Mucormycosis of the scalp is a rare cutaneous presentation of the disease. It is also an unusual infection in children. We present the case of a 4-year-old girl with acute lymphoblastic leukemia, who presented with atypical cutaneous mucormycosis simulating an lesion. Read More

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http://dx.doi.org/10.3315/jdcr.2017.1248DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5776029PMC
December 2017
5 Reads

Estimating the proportion of clinically diagnosed infectious and non-infectious animal diseases in Ganta Afeshum woreda, Eastern Tigray zone, Ethiopia.

BMC Res Notes 2018 Jan 15;11(1):29. Epub 2018 Jan 15.

Department of Biomedical Sciences, College of Veterinary Medicine and Animal Sciences, The University of Gondar, P.O. Box: 196, Gondar, Ethiopia.

Objective: This study was performed with the objective of identifying the proportion of emerging and endemic livestock diseases using cross sectional survey.

Result: A total of 285 clinically diseased animals were presented to a veterinary clinic and diagnosed tentatively based on history, clinical sign, and simple laboratory diagnostics and from the study, actinomycosis (15.83%), mastitis (15%), tick infestation (10%), respiratory diseases (9. Read More

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http://dx.doi.org/10.1186/s13104-018-3158-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5769284PMC
January 2018
15 Reads

Molecular identification and investigations of contagious ecthyma (Orf virus) in small ruminants, North west Ethiopia.

BMC Vet Res 2018 Jan 15;14(1):13. Epub 2018 Jan 15.

Department of Clinical Studies, University of Gondar, College of Veterinary Medicine and Animal Sciences, P.O. Box: 196, Gondar, Ethiopia.

Background: Orf virus, the prototype of parapoxvirus, is the main causative agent of contagious ecthyma. Little is known about the status of the disease in Ethiopia and this study was aimed at determining its status using PCR as a confirmatory tool.

Methods: a total of 400 randomly selected sheep and goat was screened for the identification of the virus using amplification of B2L gene and transfection of mammalian cells (VERO cells). Read More

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http://dx.doi.org/10.1186/s12917-018-1339-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5769459PMC
January 2018
30 Reads

Orf (ecthyma contagiosum) in a sheep and a shepherd.

Lancet Infect Dis 2018 Jan 20;18(1):122. Epub 2017 Dec 20.

Department of Dermatology, Venereology and Allergology, University Medical Center Göttingen, Göttingen, Germany. Electronic address:

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http://dx.doi.org/10.1016/S1473-3099(17)30317-1DOI Listing
January 2018
7 Reads

Clinical Guidelines for the Antibiotic Treatment for Community-Acquired Skin and Soft Tissue Infection.

Infect Chemother 2017 Dec;49(4):301-325

Department of Internal Medicine, Inje University Ilsan Paik Hospital, Goyang, Korea.

Skin and soft tissue infection (SSTI) is common and important infectious disease. This work represents an update to 2012 Korean guideline for SSTI. The present guideline was developed by the adaptation method. Read More

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http://dx.doi.org/10.3947/ic.2017.49.4.301DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5754343PMC
December 2017
15 Reads

A parapoxviral virion protein targets the retinoblastoma protein to inhibit NF-κB signaling.

PLoS Pathog 2017 12 15;13(12):e1006779. Epub 2017 Dec 15.

Department of Pathobiology, College of Veterinary Medicine, University of Illinois at Urbana- Champaign, Urbana, IL, United States of America.

Poxviruses have evolved multiple strategies to subvert signaling by Nuclear Factor κB (NF-κB), a crucial regulator of host innate immune responses. Here, we describe an orf virus (ORFV) virion-associated protein, ORFV119, which inhibits NF-κB signaling very early in infection (≤ 30 min post infection). ORFV119 NF-κB inhibitory activity was found unimpaired upon translation inhibition, suggesting that virion ORFV119 alone is responsible for early interference in signaling. Read More

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http://dx.doi.org/10.1371/journal.ppat.1006779DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5747488PMC
December 2017
12 Reads

Rapidly Growing Nodule on the Finger of a 20-year-old Woman: A Quiz.

Acta Derm Venereol 2018 Apr;98(4):469-470

Department of Dermatology and Allergy, Technical University of Munich, Biedersteiner Str. 29, DE-80802 Munich, Germany.

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http://dx.doi.org/10.2340/00015555-2868DOI Listing
April 2018
13 Reads

[Multiple well demarcated skin erosions and ulcers following exanthematous drug eruption after sultamicillin therapy].

Hautarzt 2018 Jun;69(6):484-486

Klinik für Dermatologie, Venerologie und Allergologie, Universitätsklinikum Leipzig, Philipp-Rosenthal-Str. 23, 04103, Leipzig, Deutschland.

This article presents the case of a patient with newly developed skin erosions and ulcerations following an exanthematous drug eruption due to sultamicillin therapy. The skin lesions were treated topically with clobetasol and prednicarbate and orally with methylprednisolone. A skin smear revealed massive growth of Escherichia coli bacteria. Read More

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http://link.springer.com/10.1007/s00105-017-4090-5
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http://dx.doi.org/10.1007/s00105-017-4090-5DOI Listing
June 2018
23 Reads

Ecthyma Gangrenosum.

N Engl J Med 2017 Dec;377(23):e32

Sint Antonius Ziekenhuis, Nieuwegein, the Netherlands

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http://dx.doi.org/10.1056/NEJMicm1702302DOI Listing
December 2017
7 Reads

Ecthyma gangrenosum: a report of eight cases.

An Bras Dermatol 2017 Sep-Oct;92(5):698-700

Department of Dermatology, University Hospital "Dr. José Eleuterio González", Universidad Autónoma de Nuevo León - Monterrey, México.

Ecthyma gangrenosum is a rare skin infection classically associated with Pseudomonas aeruginosa. We performed a retrospective study of all cases diagnosed with ecthyma gangrenosum from 2004-2010 in a university hospital in Mexico (8 cases, 5 female patients and 3 male patients, ages between 4 months and 2 years). The most common risk factor for ecthyma gangrenosum is neutropenia in immunocompromised patients. Read More

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http://dx.doi.org/10.1590/abd1806-4841.20175580DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5674706PMC
February 2018
12 Reads