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An Bras Dermatol 2020 Jul 15. Epub 2020 Jul 15.

Department of Dermatology, Faculty of Medicine, University of Chile, Santiago, Chile.

IDCases 2020 30;21:e00854. Epub 2020 May 30.

Section of Infectious Diseases, Tulane University School of Medicine, 1430 Tulane Avenue, New Orleans, LA, 70112, USA.

Human orf, also called ecthyma contagiosum, is a zoonotic infection that causes self-resolving skin lesions after contact with infected livestock. We present the case of a 45-year-old Moroccan-born man who developed multiple painful erythematous, violaceous plaques on his hands after butchering a sheep to celebrate the Muslim holiday Eid al-Adha. The diagnosis of orf virus infection was established based on exposure history, histopathology, and classic skin lesions. Read More

An Bras Dermatol 2020 Jul - Aug;95(4):407-417. Epub 2020 May 16.

Faculdade de Medicina, Universidade Estadual Paulista, Botucatu, SP, Brazil. Electronic address:

The severe bacterial diseases discussed herein are those that present dermatological lesions as their initial manifestations, for which the dermatologist is often called upon to give an opinion or is even the first to examine the patient. This review focuses on those that evolve with skin necrosis during their natural history, that is, necrotizing fasciitis, Fournier gangrene, and ecthyma gangrenosum. Notice that the more descriptive terminology was adopted; each disease was individualized, rather than being referred by the generic term "necrotizing soft tissue infections". Read More

Int J Infect Dis 2020 Aug 1;97:19-20. Epub 2020 Jun 1.

Service de médecine intensive et reanimation, hôpital Saint-Louis, 1 Avenue Claude Vellefaux, 75010, Paris, France.

Transpl Infect Dis 2020 May 12:e13319. Epub 2020 May 12.

Division of Infectious Diseases, Department of Internal Medicine, Wake Forest Baptist Health, Winston-Salem, NC, USA.

Ecthyma gangrenosum is a cutaneous manifestation of severe systemic pseudomonas infection and is commonly associated with bacteremia. It is common in immunocompromised patients with underlying neutropenia or leukopenia. We report a patient with heart transplant who developed a single lesion of ecthyma gangrenosum in the absence of bacteremia with a review of reported cases in solid organ transplant patients. Read More

Orbit 2020 Apr 30. Epub 2020 Apr 30.

Department of Dermatology, Austin Regional Clinic, Austin, TX, USA.

J Microbiol Immunol Infect 2020 Apr 17. Epub 2020 Apr 17.

Department of Pediatrics, Shuang Ho Hospital, Taipei Medical University, Taipei, Taiwan; Department of Pediatrics, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan. Electronic address:

X-linked agammaglobulinemia (XLA) is a primary immunodeficiency disease. We reported two 7-month-old identical male twins with Pseudomonas aeruginosa sepsis who initially manifested as oral ecthyma gangrenosum and were finally diagnosed to have XLA. In both cases, we confirmed the c. Read More

BMC Biotechnol 2020 Mar 23;20(1):18. Epub 2020 Mar 23.

Department of Microbiology, School of Biology, College of Science, University of Tehran, Tehran, Iran.

Background: Contagious ecthyma or Orf is known as a zoonotic disease remains prevalently worldwide despite the application of some control strategies against it. RNAi particularly shRNA provides us with the chance to tackle this obstacle by an encouraging new approach. The current study indicates the design and experiment of third-generation lentivirus packaging systems delivering shRNAs to inhibit Orf virus (ORFV) replication and infection. Read More

Heliyon 2020 Mar 21;6(3):e03595. Epub 2020 Mar 21.

Veterinary Laboratories Division, Animal Wealth Sector, Abu Dhabi Agriculture and Food Safety Authority P. O. Box 52150, Abu Dhabi, United Arab Emirates.

In this study, livestock herders in eastern Sudan were interviewed through structured questionnaire involved 14046 animals in 151 herds (87 camel herds, 51 sheep and 13 goats) from June to September of 2016 in Showak area of Gadarif State to get some epidemiological information on contagious ecthyma (CE) infection. 102 suspected cases of CE were investigated (38 sheep, 22 goats and 42 camels) by a second questionnaire focusing on age and sex of affected animals beside number and localization of the lesions. Representative tissue samples of scab lesion scrapings were collected from a total of 36 suspected sheep, goats and camels for DNA extraction to identify PPV by quantitative real-time PCR and gel-based PCR, then a PCR protocol was used to obtain DNA fragment of B2L gene from six DNAs (2 from each animal species) for sequencing. Read More

J Clin Rheumatol 2020 Feb 19. Epub 2020 Feb 19.

From the University of Florida Health, Jacksonville, FL.

Curr Opin Infect Dis 2020 Apr;33(2):101-109

Division of Infectious Diseases, Department of Health Sciences DISSAL, University of Genoa.

Purpose Of Review: Skin and soft tissue infections (SSTIs) in patients with hematological malignancies are frequent, but dedicated epidemiological studies are limited. The aim of this review is to provide updated description of the main etiological agents, differential diagnosis, and treatment.

Recent Findings: In addition to common causes of bacterial skin infections in any kind of patients, such as streptococci and staphylococci (the letter frequently resistant to methicillin), Pseudomonas aeruginosa is a frequent agent in patients with hematological malignancies, with high virulence and typical infection presenting as ecthyma gangrenosum. Read More

FP Essent 2020 Feb;489:11-15

Maine-Dartmouth Family Medicine Residency, 15 East Chestnut St, Augusta, ME 04330.

Patients with bacterial skin and soft tissue infections (SSTIs) commonly present to family physicians. Common uncomplicated bacterial SSTIs include impetigo, ecthyma, cellulitis, erysipelas, abscesses, furuncles, and carbuncles. Risk factors for SSTIs include older age and chronic medical conditions, such as diabetes and cardiopulmonary or renal disease, and immunocompromise. Read More

Acta Dermatovenerol Croat 2019 Dec;27(4):280-281

Luis Santiago, MD, Dermatology Department Centro Hospitalar e Universitário de Coimbra, Praceta Prof. Mota Pinto, 3000-075 Coimbra, Portugal;

Dear Editor, Orf, also called contagious ecthyma, contagious pustular dermatitis, sore mouth, or scabby mouth, is a highly contagious zoonotic disease which is caused by a double-stranded DNA virus, ORFV (Parapoxvirus genus of the family Poxviridae) (1). The infection is endemic to sheep and goats, and humans are infected either through direct transmission from active lesions on infected animals or through contact with fomites (2). Orf is an occupational hazard and the population at risk includes shepherds, butchers, farmers, wool shearers, and veterinarians (2,3). Read More

Vet Ital 2019 12 31;55(4):347-353. Epub 2019 Dec 31.

Istituto Zooprofilattico Sperimentale della Puglia e della Basilicata, Via Manfredonia 20, 71121 Foggia.

Orf virus (ORFV; Family: Poxviridae) is the causative agent of contagious ecthyma, or Orf disease in sheep, goats and other domestic or wild ruminants with a worldwide distribution. The disease is endemic in Italy, but few data are available about its distribution and epidemiology. In the present study we analysed 32 clinical samples, obtained from crusted scab lesions of 5 goats and 27 sheep, from 19 suspected outbreaks of contagious ecthyma in Apulia and Basilicata regions between 2012 and 2014. Read More

Clin Dermatol 2019 Sep - Oct;37(5):528-547. Epub 2019 Jul 17.

The Ronald O. Perelman Department of Dermatology, New York University School of Medicine, New York, New York, USA. Electronic address:

The color purple can be seen in several types of eruptions including inflammatory dermatoses like lichen planus, infectious dermatoses like ecthyma gangrenosum, neoplasms like Kaposi sarcoma, and vasculitis and vasculopathy. The current review focuses on the clinical appearance, pathophysiology, and treatment of several vasculitides and vasculopathies including capillaritis, cutaneous small-vessel vasculitis, immunoglobulin A (IgA) vasculitis, cryoglobulinemia, granulomatosis with polyangiitis, eosinophilic granulomatosis with polyangiitis, microscopic polyangiitis, polyarteritis nodosum, warfarin-induced skin necrosis, heparin-induced thrombocytopenia, purpura fulminans, antiphospholipid antibody syndrome, calciphylaxis, levamisole-induced vasculopathy, and thrombotic thrombocytopenic purpura. Dermatologists play a central role in treating patients with cutaneous vasculitis and vasculopathy and may have the opportunity to facilitate identification of systemic disease by diagnosing cutaneous vasculitis and vasculopathy. Read More

BMC Biotechnol 2019 12 23;19(1):102. Epub 2019 Dec 23.

College of Veterinary Medicine, Northwest A&F University, Yangling, 712100, Shaanxi Province, China.

Background: Interferon-gamma (IFN-γ) is an important mediator of type I immune response and has antiviral, immunoregulatory and anti-tumor properties, plays a wide range of roles in inflammation and autoimmune diseases. The aim of this study was to obtain monoclonal antibody (mAb) against caprine IFN-γ by immunizing of BALB/c mice with the purified rIFN-γ.

Results: Recombinant caprine IFN-γ was expressed in Escherichia coli strain BL21 (DE3) and monoclonal antibodies against caprine IFN-γ were produced by immunizing of BALB/c mice with rIFN-γ. Read More

N Z Med J 2019 11 8;132(1506):93-95. Epub 2019 Nov 8.

Dermatology, Waikato District Health Board, Hamilton.

Pediatr Dermatol 2020 Jan 22;37(1):103-108. Epub 2019 Nov 22.

Division of Pediatric Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Background: Bullous impetigo (BI) is a common skin infection of early childhood, resulting from desmoglein-1 cleavage by Staphylococcus aureus exfoliative toxins. Due to compromised barrier function and immune dysregulation, children with atopic dermatitis (AD) are at increased risk of cutaneous infections, yet no literature has been published on disseminated bullous impetigo (DBI) in children with atopic dermatitis (AD). We sought to explore the atopic phenotypes, antibiotic sensitivities, and treatment courses of children diagnosed with disseminated bullous impetigo at our institution. Read More

Emerg Infect Dis 2019 12;25(12):2197-2204

Zoonotic transmission of parapoxvirus from animals to humans has been reported; clinical manifestations are skin lesions on the fingers and hands after contact with infected animals. We report a human infection clinically suspected as being ecthyma contagiosum. The patient, a 65-year-old woman, had 3 nodules on her hands. Read More

Cureus 2019 Aug 31;11(8):e5543. Epub 2019 Aug 31.

Neurological Surgery, Mayo Clinic, Rochester, USA.

Ecthyma gangrenosum is a rare physical exam finding pathognomonic for severe bacteremia and typically associated with pseudomonal sepsis. The characteristic skin lesions appear as ring-shaped hemorrhagic pustules that evolve into necrotic ulcers. In the present case, a 62-year-old woman with a pulmonary adenocarcinoma treated with surgical resection and adjuvant chemotherapy developed three symptomatic brain masses. Read More

Infect Genet Evol 2020 01 31;77:104076. Epub 2019 Oct 31.

Virology Unit, Department of Pathology and Microbiology, Faculty of Veterinary Medicine, University Putra Malaysia, 43400 Serdang, Selangor, Malaysia. Electronic address:

There is a little information on the characterization of Orf virus strains that are endemic in Malaysia. The relationship between the severity of disease and the molecular genetic profile of Orf virus strains has not been fully elucidated. This study documented the first confirmed report of contagious ecthyma causing by Orf virus in goats from a selected state of eastern peninsular Malaysia. Read More

Proc (Bayl Univ Med Cent) 2019 Oct 2;32(4):593-595. Epub 2019 Aug 2.

Department of Internal Medicine, Texas Health Presbyterian HospitalDallasTexas.

Ecthyma gangrenosum is a rare and highly lethal cutaneous infection classically associated with bacteremia. We report a 58-year-old man with multiple myeloma receiving chemotherapy who presented with 2 days of painless left periorbital swelling that rapidly progressed to a blackish eschar. His absolute neutrophil count was 0. Read More

Clin Case Rep 2019 Sep 9;7(9):1754-1756. Epub 2019 Aug 9.

Service de Dermatologie CHU and EA3181 Besançon France.

The diagnosis of ecthyma gangrenosum should be evoked in front of maculopapular lesions rapidly evolving to necroting ulcers, particularly in the presence of prolonged neutropaenia or other hematological malignancies. Read More

Am J Case Rep 2019 Sep 16;20:1369-1372. Epub 2019 Sep 16.

Office of Human Research, Memorial Healthcare System, Hollywood, FL, USA.

BACKGROUND Ecthyma gangrenosum is an uncommon cutaneous infection commonly caused by Pseudomonas aeruginosa affecting typically immunocompromised patients. The presence of ecthyma gangrenosum can be associated with severe systemic infection often with a fatal prognosis. Most cases of ecthyma gangrenosum occur around the axilla, buttocks, and limbs; the scrotum is rarely affected. Read More

Acta Virol 2019 ;63(3):270-277

Orf, also called contagious ecthyma or contagious pustular dermatitis, is a significant zoonotic disease that primarily affects goat and sheep globally. Currently, the infection by orf virus (ORFV) has been observed in different host species worldwide, including China. Here, a suspected outbreak of orf infection in a goat farm in Anhui Province in 2018 was investigated. Read More

Front Immunol 2019 20;10:1953. Epub 2019 Aug 20.

Department of Pediatrics, Taichung Veterans General Hospital, Taichung, Taiwan.

X-linked agammaglobulinemia (XLA), caused by a mutation in the Bruton's tyrosine kinase () gene, is rarely reported in patients with recurrent hemophagocytic lymphohistiocytosis (HLH). This mutation leads to significantly reduced numbers of circulatory B cells and serum immunoglobulins in patients. Therefore, they exhibit repetitive bacterial infections since infancy, and immunoglobulin (Ig) replacement therapy is the primary treatment. Read More

Int Wound J 2019 Dec 2;16(6):1575-1576. Epub 2019 Sep 2.

UOC Pediatria, Sant'Andrea Hospital, Rome, Italy.

IDCases 2019 11;18:e00594. Epub 2019 Jul 11.

Department of Pathology, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla, Thailand.

Calciphylaxis is a rare cutaneous disease that may cause fatal complications in patients on long-term dialysis. Early diagnosis and proper management decrease complications. However, it can mimic cutaneous infections, especially ecthyma gangrenosum and cutaneous vasculitis. Read More

Vet Rec 2019 09 20;185(10):305. Epub 2019 Jul 20.

School of Veterinary Medicine and Science, University of Nottingham, Nottingham, UK.

Orf, a parapoxvirus, is a zoonosis causing a contagious pustular dermatitis, and has a high morbidity in sheep worldwide. Despite a vaccine being available, orf prevalence in England is estimated to be 2 per cent in ewes and 20 per cent in lambs​​. There is concern that farmers are not complying with the vaccination guidelines and therefore the objective of this study was to investigate if orf vaccine is used correctly on sheep farms in the UK and to identify barriers and motivators of sheep farmers to use the vaccine. Read More

BMC Vet Res 2019 Jul 18;15(1):250. Epub 2019 Jul 18.

Virology Unit, Department of Pathology and Microbiology, Faculty of Veterinary Medicine, Universiti Putra Malaysia, 43400, Serdang, Selangor, Malaysia.

Background: Orf virus causes a scabby skin lesions which decreases productivity in small ruminants. The unknown status of this disease in the eastern region of Peninsular Malaysia warrants a study to determine sero-prevalence of orf with regards to farmers' compliance level towards the Herd Health Program (HHP) programme.

Results: Out of 504 animals, 115 were positive for Orf-virus antibodies. Read More

Emerg Infect Dis 2019 08;25(8):1585-1586

Orf (ecthyma contagiosum) is an infection of the skin caused by a DNA virus belonging to the genus Parapoxvirus. We recently observed 7 cases of orf in Muslim men living in the metropolitan area of Milan, Italy, who acquired the infection after the Feast of Sacrifice. Read More

Comp Immunol Microbiol Infect Dis 2019 Aug 26;65:1-6. Epub 2019 Mar 26.

Department of Virology, Veterinary Faculty, Hatay Mustafa Kemal University, Antakya, 31040 Hatay, Turkey. Electronic address:

Orf virus (ORFV) causes contagious skin disease that mainly affects sheep and goats with zoonotic potential. However, there is not enough information about the association between ORFV and occurrence of skin disease in cattle. The present study describes outbreaks of ORFV infection in cattle in different provinces that are located in the Aegean, Central Anatolian and Mediterranean regions of Turkey. Read More

J Am Vet Med Assoc 2019 08;255(3):313-316

Transpl Infect Dis 2019 Aug 30;21(4):e13131. Epub 2019 Jun 30.

Division of Infectious Diseases, Department Medical Subspecialties, National Center for Child Health and Development, Setagaya-ku, Japan.

Ecthyma gangrenosum (EG) is a serious bacterial infection in immunocompromised patients. EG in transplant recipients is rarely reported and may go unrecognized, which may delay initiation of appropriate treatment. We report a case of EG in a pediatric heart transplant recipient who was treated successfully with antibiotics and surgical debridement. Read More

J Oncol Pharm Pract 2020 Mar 19;26(2):487-491. Epub 2019 Jun 19.

National Center for Cancer Care and Research, Hamad Medical Corporation (HMC), Doha, Qatar.

Introduction: Ibrutinib is an oral inhibitor of Bruton's tyrosine kinase that is used for a variety of B cell hematological malignancies. Skin and subcutaneous tissue manifestations have been reported and were witnessed in up to 32% of the patients on ibrutinib. The mechanism in which ibrutinib can cause skin toxicities has been thought due to the inhibition of epidermal growth factor; c-Kit and platelet-derived growth factor receptor). Read More

Acta Clin Belg 2019 Jun 18:1-5. Epub 2019 Jun 18.

c Infectious Diseases Department , Saint-Pierre-University Hospital, Université Libre de Bruxelles , Belgium.

Ecthyma gangrenosum (EG) is a potentially lethal skin infection, most commonly due to with bacteremic dissemination and affecting mostly immunocompromised patients. We present two cases of EG in two men in Belgium recently admitted to our hospital, caused by a suspected coinfection by group A and , with a cutaneous dissemination, in which multiple impetigo lesions were the portal of entry. The first patient had no risk factors nor immunodeficiency, but the second was a homeless man with drug and alcohol abuse and advanced HIV infection. Read More

Medicine (Baltimore) 2019 May;98(20):e15651

Lucian Blaga University of Sibiu, Faculty of Medicine Sibiu.

Rationale: Ecthyma gangrenosum is a cutaneous infection, most commonly occurring during sepsis evolution with Pseudomonas aeruginosa on an immunocompromised background. There have been rare case reports in previously healthy children and rarer are the cases with double etiology.

Patient Concerns: We present the case of a female Caucasian patient, aged 1 year and 8 months, who developed severe sepsis during flu evolution with predominant respiratory and cerebral manifestations. Read More

Front Vet Sci 2019 18;6:126. Epub 2019 Apr 18.

Kungsängens Gård, Farm and Animal Health, Uppsala, Sweden.

Supplementary winter feeding of semi-domesticated reindeer () has become more common in Sweden and Norway due to reindeer pasture fragmentation and climatic conditions. With increased corralling and feeding, often associated with animal stress, increased animal-to-animal contact, and poor hygienic conditions, an altered range of health challenges and diseases may emerge. An outbreak of three different infectious diseases appeared simultaneously in a reindeer herd in Norrbotten County, Sweden. Read More

Curr Med Mycol 2019 Mar;5(1):27-31

Department of Microbiology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Background And Purpose: species is an opportunistic mold that causes disseminated infections in immunocompromised patients. Given the high mortality rate of this infection, it is important to make a definite diagnosis when encountering suspected cases.

Case Report: Herein, we presented a 35-year-old man diagnosed with acute myeloid leukemia with a prolonged febrile neutropenic period and ecthyma gangrenosum-like lesions, along with fungemia and disseminated fusariosis. Read More

Virus Genes 2019 Aug 27;55(4):490-501. Epub 2019 Apr 27.

Key Laboratory of Zoonosis Research, Ministry of Education, College of Veterinary Medicine, Jilin University, Changchun, China.

Orf virus (ORFV), a typical member of the Parapoxvirus genus within the family Poxviridae, which is the causative agent of Orf, a common epitheliotropic viral disease of sheep, goats, wild ruminants, and humans. In the present study, we sequenced the complete genomic sequences of two ORFV strains (ORFV-SY17, isolated from sheep, and ORFV-NA17, isolated from goat) and conducted the comparative analysis of multiple ORFVs. The complete genomic sequence of ORFV-SY17 was at length of 140,413 bp, including 131 potential open reading frames (ORFs) flanked by inverted terminal repeats (ITRs) of 4267 bp at both ends. Read More

Proc (Bayl Univ Med Cent) 2018 Oct 20;31(4):528-529. Epub 2018 Sep 20.

Department of Internal Medicine, Scott & White Memorial HospitalTempleTexas.

Ecthyma gangrenosum is an exceedingly rare dermatologic complication of bacteremia or fungemia in immunocompromised patients. The lesions may be single or multiple and may occur anywhere on the body. We present a case of ecthyma gangrenosum with atypical organisms and risk factors resulting in delayed diagnosis of both the condition and the underlying infectious process that caused it. Read More

Dermatol Ther 2019 05 16;32(3):e12887. Epub 2019 Apr 16.

Department of Dermatology, Venereology & Leprology, All India Institute of Medical Sciences, Jodhpur, India.

Platelet rich fibrin (PRF) gel is a new second generation platelet concentrate, which has been widely used in various dermatological conditions such as nonhealing diabetic foot ulcers, venous ulcers, and trophic ulcers in leprosy. In this case report, we present a patient with nonhealing ulcer secondary to ecthyma gangrenosum, who showed dramatic response with PRF gel. This case suggests a role of PRF gel in nonhealing ulcers of infectious etiology which has not been described in English language literature. Read More

J Cutan Pathol 2019 Jun 4;46(6):459-462. Epub 2019 Apr 4.

Department of Dermatology, New York-Presbyterian Hospital/Weill Cornell Medical Center, New York City, New York.

Braz J Microbiol 2019 Apr 5;50(2):565-569. Epub 2019 Mar 5.

Plataforma de Investigación en Salud Animal, Instituto Nacional de Investigación Agropecuaria (INIA), Ruta 50 Km 11, La Estanzuela, Colonia, Uruguay.

Orf virus (ORFV) causes contagious ecthyma (CE), a highly transmissible, zoonotic disease of small ruminants. CE most commonly affects lambs and unvaccinated sheep. This work reports epidemiologic, clinicopathologic, and virologic findings in a CE outbreak in a vaccinated sheep flock in Uruguay and failure to detect ORFV in a commercial vaccine. Read More

J Glob Infect Dis 2019 Jan-Mar;11(1):43-46

Department of Internal Medicine, University of Calabar, Calabar, Cross River State, Nigeria.

Ecthyma gangrenosum (EG) is a rare, infective skin disease, predominantly but not exclusively caused by . It is often seen in individuals with immunosuppression, although it has also been reported among previously healthy individuals. It was initially thought to be pathognomonic of septicemia, but this assertion was discarded following several reports on EG without bacteremia and EG with varied bacterial and fungal etiologies. Read More

BMC Pediatr 2019 01 31;19(1):40. Epub 2019 Jan 31.

Department of Pediatric Emergency Department, Dr. Behçet Uz Children's Hospital, İzmir, Turkey.

Objective: Smartphones and associated messaging applications have become the most common means of communication among health care workers and the general population. The aim of this study was to evaluate the reliability and accuracy of smartphones for the diagnosis of rash in children admitted to emergency departments during the night shift.

Methods: The images of the children who were admitted to the paediatric emergency department with rash were included in this study, and at least two images taken with smartphones by residents or paediatric infectious disease fellows were re-directed to the chief consultant of the Paediatric-Infectious Department via smartphone. Read More

PLoS One 2019 30;14(1):e0210504. Epub 2019 Jan 30.

Institute of Immunology/Molecular Pathogenesis, Center for Biotechnology and Biomedicine, College of Veterinary Medicine, University of Leipzig, Leipzig, Germany.

ORF virus (ORFV) is the causative agent of contagious ecthyma, a pustular dermatitis of small ruminants and humans. Even though the development of lesions caused by ORFV was extensively studied in animals, only limited knowledge exists about the lesion development in human skin. The aim of the present study was to evaluate a three-dimensional (3D) organotypic culture (OTC) as a human skin model for ORFV infection considering lesion development, replication of the virus, viral gene transcription and modulation of differentiation of human keratinocytes by ORFV. Read More

BMC Infect Dis 2019 Jan 25;19(1):85. Epub 2019 Jan 25.

Department of Internal Medicine, St Antonius Hospital, Nieuwegein/ Utrecht, Koekoekslaan 1, 3435, CM, Nieuwegein, The Netherlands.

Background: Ecthyma gangrenosum is a cutaneous infectious usually associated with P. aeruginosa. It usually develops In patients with an underlying immunodeficiency. Read More

J Virol 2019 04 21;93(7). Epub 2019 Mar 21.

Graduate Institute of Microbiology and Public Health, National Chung Hsing University, Taichung, Taiwan

Orf virus (ORFV) infects sheep and goats and is also an important zoonotic pathogen. The viral protein OV20.0 has been shown to suppress innate immunity by targeting the double-stranded RNA (dsRNA)-activated protein kinase (PKR) by multiple mechanisms. Read More

J Eur Acad Dermatol Venereol 2019 Apr 5;33(4):781-785. Epub 2019 Mar 5.

Department of Dermatology, University Hospital Antwerp (UZA), University of Antwerp (UA), Antwerp, Belgium.

Background: Ecthyma gangrenosum (EG) is characterized by the occurrence of erythematous, violaceous or haemorrhagic macules and/or vesicles, often evolving into necrotic ulcers, with a central grey-black eschar. It is a rare skin condition, usually occurring in immunocompromised patients suffering from bacterial sepsis caused by Pseudomonas aeruginosa. However, seemingly healthy children have been diagnosed with this skin disease as well. Read More