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    [Orf virus in human, confirmation in case report from Chile].
    Rev Chilena Infectol 2017 Dec;34(6):607-609
    Facultad de Ciencias, Universidad Mayor, Santiago, Chile.
    Infection with the orf virus, also known as contagious ecthyma, is recognized as an occupational zoonosis worldwide. It is diagnosed by cutaneous lesions that progress rapidly from macules to papules, vesicles and pustules. The clinical case of a student of veterinary medicine who had had contact with goats, clinically healthy and without apparent lesions, which occured 19 days ago, is reported. Read More

    Orf virus infection in Alaskan mountain goats, Dall's sheep, muskoxen, caribou and Sitka black-tailed deer.
    Acta Vet Scand 2018 Feb 21;60(1):12. Epub 2018 Feb 21.
    Department of Nursing and Health Sciences-Vestfold, Faculty of Health and Social Sciences, University College of Southeast Norway, 3603, Kongsberg, Norway.
    Background: The zoonotic Orf virus (ORFV; genus Parapoxvirus, Poxviridae family) occurs worldwide and is transmitted between sheep and goats, wildlife and man. Archived tissue samples from 16 Alaskan wildlife cases, representing mountain goat (Oreamnos americanus, n = 8), Dall's sheep (Ovis dalli dalli, n = 3), muskox (Ovibos moschatus, n = 3), Sitka black-tailed deer (Odocoileus hemionus sitkensis, n = 1) and caribou (Rangifer tarandus granti, n = 1), were analyzed.

    Results: Clinical signs and pathology were most severe in mountain goats, affecting most mucocutaneous regions, including palpebrae, nares, lips, anus, prepuce or vulva, as well as coronary bands. Read More

    Molekulare Diagnostik von Hautinfektionen am Paraffinmaterial - Übersicht und interdisziplinärer Konsensus.
    J Dtsch Dermatol Ges 2018 Feb;16(2):139-148
    Mikrobiologisches Institut - Klinische Mikrobiologie, Immunologie und Hygiene, Universitätsklinikum Erlangen und Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg.
    Nukleinsäure-Amplifikations-Techniken (NAT), wie die PCR, sind hochsensitiv sowie selektiv und stellen in der mikrobiologischen Diagnostik wertvolle Ergänzungen zur kulturellen Anzucht und Serologie dar. Sie bergen aber gerade bei formalinfixiertem und in Paraffin eingebettetem Gewebe ein Risiko für sowohl falsch negative als auch falsch positive Resultate, welches nicht immer richtig eingeschätzt wird. Daher haben Vertreter der Deutschen Gesellschaft für Hygiene und Mikrobiologie (DGHM) und der Deutschen Dermatologischen Gesellschaft (DDG) einen Konsensus in Form einer Übersichtsarbeit erarbeitet, wann eine NAT am Paraffinschnitt angezeigt und sinnvoll ist und welche Punkte dabei in der Präanalytik und Befundinterpretation beachtet werden müssen. Read More

    Molecular diagnosis of skin infections using paraffin-embedded tissue - review and interdisciplinary consensus.
    J Dtsch Dermatol Ges 2018 Feb;16(2):139-147
    Institute of Microbiology - Clinical Microbiology, Immunology, and Hygiene, University Medical Center and Friedrich Alexander University Erlangen-Nuremberg, Erlangen, Germany.
    Nucleic acid amplification techniques (NATs), such as PCR, are highly sensitive and specific methods that have become valuable supplements to culture and serology in the diagnosis of infectious disorders. However, especially when using formalin-fixed and paraffin-embedded tissue, these techniques are associated with both false-negative and false-positive results, a pitfall that is frequently misjudged. Representatives of the German Society of Hygiene and Microbiology (DGHM) and the German Society of Dermatology (DDG) therefore set out to develop a consensus - in the form of a review article - on the appropriate indications for NATs using paraffin-embedded tissue, its contraindications, and the key points to be considered in the pre- and post-analytical phase. Read More

    Genetic diversity of Orf virus isolated from sheep in Uruguay.
    Arch Virol 2018 May 24;163(5):1285-1291. Epub 2018 Jan 24.
    Sección Virología, Facultad de Ciencias, UdelaR, Iguá 4225, 11400, Montevideo, Uruguay.
    Orf virus (ORFV) is the etiological agent of contagious ecthyma, a disease widely spread in the world that occasionally causes zoonotic infections. This work is the first molecular characterization of ORFV in Uruguay, where we analyzed twenty-one sheep samples, eighteen of which were recovered from thirteen ORFV outbreaks that occurred during 2004 to 2011 as well as three strains from a national vaccine. Phylogenetic analysis and the derived amino acid sequences from the B2L gene suggest that the Uruguayan virus do not form a unique cluster, with most of them displaying similarities with worldwide ORFV isolates as well as our vaccine strains. Read More

    Photoletter to the editor: Atypical primary cutaneous mucormycosis of the scalp.
    J Dermatol Case Rep 2017 Dec 1;11(2):32-34. Epub 2017 Dec 1.
    Micology Department, General Hospital "Dr. Manuel Gea González", Mexico City, Mexico.
    Mucormycosis of the scalp is a rare cutaneous presentation of the disease. It is also an unusual infection in children. We present the case of a 4-year-old girl with acute lymphoblastic leukemia, who presented with atypical cutaneous mucormycosis simulating an lesion. Read More

    Estimating the proportion of clinically diagnosed infectious and non-infectious animal diseases in Ganta Afeshum woreda, Eastern Tigray zone, Ethiopia.
    BMC Res Notes 2018 Jan 15;11(1):29. Epub 2018 Jan 15.
    Department of Biomedical Sciences, College of Veterinary Medicine and Animal Sciences, The University of Gondar, P.O. Box: 196, Gondar, Ethiopia.
    Objective: This study was performed with the objective of identifying the proportion of emerging and endemic livestock diseases using cross sectional survey.

    Result: A total of 285 clinically diseased animals were presented to a veterinary clinic and diagnosed tentatively based on history, clinical sign, and simple laboratory diagnostics and from the study, actinomycosis (15.83%), mastitis (15%), tick infestation (10%), respiratory diseases (9. Read More

    Molecular identification and investigations of contagious ecthyma (Orf virus) in small ruminants, North west Ethiopia.
    BMC Vet Res 2018 Jan 15;14(1):13. Epub 2018 Jan 15.
    Department of Clinical Studies, University of Gondar, College of Veterinary Medicine and Animal Sciences, P.O. Box: 196, Gondar, Ethiopia.
    Background: Orf virus, the prototype of parapoxvirus, is the main causative agent of contagious ecthyma. Little is known about the status of the disease in Ethiopia and this study was aimed at determining its status using PCR as a confirmatory tool.

    Methods: a total of 400 randomly selected sheep and goat was screened for the identification of the virus using amplification of B2L gene and transfection of mammalian cells (VERO cells). Read More

    Clinical Guidelines for the Antibiotic Treatment for Community-Acquired Skin and Soft Tissue Infection.
    Infect Chemother 2017 Dec;49(4):301-325
    Department of Internal Medicine, Inje University Ilsan Paik Hospital, Goyang, Korea.
    Skin and soft tissue infection (SSTI) is common and important infectious disease. This work represents an update to 2012 Korean guideline for SSTI. The present guideline was developed by the adaptation method. Read More

    [Multiple well demarcated skin erosions and ulcers following exanthematous drug eruption after sultamicillin therapy].
    Hautarzt 2017 Dec 7. Epub 2017 Dec 7.
    Klinik für Dermatologie, Venerologie und Allergologie, Universitätsklinikum Leipzig, Philipp-Rosenthal-Str. 23, 04103, Leipzig, Deutschland.
    This article presents the case of a patient with newly developed skin erosions and ulcerations following an exanthematous drug eruption due to sultamicillin therapy. The skin lesions were treated topically with clobetasol and prednicarbate and orally with methylprednisolone. A skin smear revealed massive growth of Escherichia coli bacteria. Read More

    Ecthyma gangrenosum: a report of eight cases.
    An Bras Dermatol 2017 Sep-Oct;92(5):698-700
    Department of Dermatology, University Hospital "Dr. José Eleuterio González", Universidad Autónoma de Nuevo León - Monterrey, México.
    Ecthyma gangrenosum is a rare skin infection classically associated with Pseudomonas aeruginosa. We performed a retrospective study of all cases diagnosed with ecthyma gangrenosum from 2004-2010 in a university hospital in Mexico (8 cases, 5 female patients and 3 male patients, ages between 4 months and 2 years). The most common risk factor for ecthyma gangrenosum is neutropenia in immunocompromised patients. Read More

    [A case of Orf disease complicated by erythema multiforme].
    Arch Pediatr 2017 Dec 16;24(12):1241-1243. Epub 2017 Nov 16.
    Service d'accueil des urgences, American Memorial Hospital, CHU de Reims, 47, rue Cognacq-Jay, 51100 Reims, France.
    Ecthyma contagiosum, or Orf, is a specific infection of small ruminants accidentally reaching humans. Few cases have been reported in the literature to date. We report here a case of ecthyma contagiosum occurred in a 9-year-old girl after contact with a flock of ecthyma sheep. Read More

    Ecthyma Gangrenosum in the Eyelid.
    J Craniofac Surg 2018 03;29(2):531-532
    Department of Oral and Maxillofacial Surgery, Virgen del Rocio University Hospital, Seville, Spain Department of Pathology, Virgen del Rocio University Hospital, Seville, Spain Department of Oral and Maxillofacial Surgery, Virgen del Rocio University Hospital, Seville, Spain.

    Transcriptome analysis of sheep oral mucosa response to Orf virus infection.
    PLoS One 2017 26;12(10):e0186681. Epub 2017 Oct 26.
    State Key Laboratory of Veterinary Etiological Biology, Key Laboratory of Veterinary Public Health of Ministry of Agriculture, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, Gansu, China.
    Contagious ecthyma is a highly contagious disease with worldwide distribution, which is caused by the Orf virus (ORFV) belonging to the Parapoxvirus. To study the alteration of host gene expression in response to ORFV infection at the transcriptional level, several young small-tailed Han sheep were inoculated with ORFV, and their oral mucosa tissue samples (T0, T3, T7 and T15) were collected on day 0, 3, 7 and 15 after ORFV infection respectively. RNA-seq transcriptome comparisons were performed, showing that 1928, 3219 and 2646 differentially expressed genes (DEGs) were identified among T3 vs. Read More

    Extensive orf infection in a toddler with associated id reaction.
    Pediatr Dermatol 2017 Nov 21;34(6):e337-e340. Epub 2017 Sep 21.
    Department of Pediatrics, School of Medicine, University of California, San Diego, San Diego, CA, USA.
    Orf is a zoonotic parapoxvirus typically transmitted to humans by a bite from goats or sheep. We present an unusual case of multiple orf lesions on the fingers of a 13-month-old child who was bitten by a goat and subsequently developed progressive swelling, blistering, and necrotic papulonodules of the hand followed by an additional diffuse, pruritic, papular rash. A primary diagnosis of orf infection was confirmed using real-time polymerase chain reaction, and the diffuse eruption was clinically consistent with an id reaction. Read More

    Disseminated sepsis as presenting diagnosis of X-linked agammaglobulinaemia in a previously well 16-month-old child.
    BMJ Case Rep 2017 Aug 29;2017. Epub 2017 Aug 29.
    Department of Pediatrics, All India Institute of Medical Sciences Jodphur, Jodhpur, Rajasthan, India.
    We report a previously healthy 16-month-old child who presented to us with membranous pharyngitis and ecthyma gangrenosum. In this patient, was isolated from throat swab, cerebrospinal fluid, skin swab, urine, blood and synovial fluid in a single admission. In further workup, this child was diagnosed as a case of X-linked agammaglobulinaemia. Read More

    Vasculopathies, cutaneous necrosis and emergency in dermatology.
    G Ital Dermatol Venereol 2017 Dec 28;152(6):615-637. Epub 2017 Jul 28.
    Department of Dermatology, de La Princesa University Hospital, Madrid, Spain.
    Most emergencies in dermatology comprise a variety of entities with a usually benign course. However, vasculopathies and vasculitis are not common, but they could represent respectively 1.9% and 4. Read More

    The whole genomic analysis of orf virus strain HN3/12 isolated from Henan province, central China.
    BMC Vet Res 2017 Aug 18;13(1):260. Epub 2017 Aug 18.
    Institute of Antibody Engineering, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou, 510515, People's Republic of China.
    Background: The Orf virus (ORFV) is the causative agent of orf, a globally-occurring, acute, pustular, contagious disease affecting sheep, goats and humans with a worldwide distribution. Currently, the genomic analysis of four ORFV strains from the Fujian province in southern China and a NA1/11 strain isolated from the Jilin province in northeast China have been reported. However, little is known about the genomic information of ORFV strains from central China. Read More

    A parapoxviral virion protein inhibits NF-κB signaling early in infection.
    PLoS Pathog 2017 Aug 7;13(8):e1006561. Epub 2017 Aug 7.
    Department of Pathobiology, College of Veterinary Medicine, University of Illinois at Urbana-Champaign, Urbana, Illinois, United States of America.
    Poxviruses have evolved unique proteins and mechanisms to counteract the nuclear factor κB (NF-κB) signaling pathway, which is an essential regulatory pathway of host innate immune responses. Here, we describe a NF-κB inhibitory virion protein of orf virus (ORFV), ORFV073, which functions very early in infected cells. Infection with ORFV073 gene deletion virus (OV-IA82Δ073) led to increased accumulation of NF-κB essential modulator (NEMO), marked phosphorylation of IκB kinase (IKK) subunits IKKα and IKKβ, IκBα and NF-κB subunit p65 (NF-κB-p65), and to early nuclear translocation of NF-κB-p65 in virus-infected cells (≤ 30 min post infection). Read More

    [Pseudomonas aeruginosa in dermatology].
    Ann Dermatol Venereol 2017 Nov 2;144(11):666-675. Epub 2017 Aug 2.
    Service de dermatologie, hôpital d'instruction des armées Sainte-Anne, 83800 Toulon, France. Electronic address:
    Pseudomonas aeruginosa, a ubiquitous Gram-negative bacillus characterized by its greenish color and sweetish smell, is at the origin of potentially severe forms of dermatosis, such as ecthyma gangrenosum which marks immunosuppression or reveals blood-poisoning, especially in children. It frequently colonizes chronic wounds and serious burns, and spongiotic or acantholytic dermatosis, especially when severe or localized in skinfolds. It requires special care because of its high resistance to antibiotics and antiseptics. Read More

    Non-pseudomonal ecthyma gangrenosum caused by methicillin-resistant S (MRSA) in a chronic alcoholic patient.
    BMJ Case Rep 2017 Aug 3;2017. Epub 2017 Aug 3.
    General Surgery, Sree Balaji Medical College and Hospital, Chennai, Tamil Nadu, India.
    We report for the first time a case of non-pseudomonal ecthyma gangrenosum (EG) caused by methicillin-resistant in a chronic alcoholic without an associated immunocompromised state or disease. EG is an infection of the skin, commonly associated with bacteraemia, though other organisms are also known to be causally related. It usually occurs in patients who are terminally ill and the immunocompromised. Read More

    Ecthyma gangrenosum caused by .
    BMJ Case Rep 2017 Jul 27;2017. Epub 2017 Jul 27.
    Department of Pulmonary and Critical Care, Brooke Army Medical Center, Fort Sam Houston, Texas, USA.
    A 55-year-old man undergoing chemotherapy for recurrent multiple myeloma presented with a 2-day history of bilateral lower leg rash with pain and oedema. On examination, there were numerous non-palpable retiform pruritic patches over both lower legs. Skin pnch biopsy demonstrated a diffuse interstitial neutrophilic infiltrate with necrosis. Read More

    Orf Virus Infection in Humans: A Review With a Focus on Advances in Diagnosis and Treatment.
    J Drugs Dermatol 2017 Jul;16(7):684-689
    Ecthyma contagiosum, also called contagious pustular dermatosis, is a zoonotic disease caused by the orf virus (OrfV). As a member of the poxviridae family and parapoxvirus genus, this dermatotropic virus has developed an array of mechanisms by which to evade the host immune system in both humans and animals. The ubiquitousness of this pathogen in sheep, goats, and deer has led to the development of orf in diverse areas around the world. Read More

    Skin infection caused by a novel strain of in a Siberian husky dog owner.
    JMM Case Rep 2017 Mar 20;4(3):jmmcr005087. Epub 2017 Mar 20.
    Department of Dermatology, Dumfries and Galloway Royal Infirmary, Bankend Road, Dumfries DG1 4AP, UK.
    , an opportunistic pathogen of dogs and cats, is rarely reported to cause infection in humans. Here, we describe a case of severe skin infection caused by , in a 47-year-old male, a dog owner; to the best of our knowledge, this is the first such case reported from Scotland. The patient presented with a short history of a severe ecthyma-like lesion on his forehead, with smaller lesions on his abdomen and legs. Read More

    Systemic interferon alfa injections for the treatment of a giant orf.
    Cutis 2017 May;99(5):E19-E21
    Department of Dermatology, Istanbul Training and Research Hospital, Turkey.
    Orf is a zoonotic infection caused by a parapoxvirus and is endemic in sheep and goats. It may be transmitted to humans by direct contact with infected animals. We report a case of a giant orf in a patient with chronic lymphocytic leukemia (CLL), which proliferated dramatically after surgical excision and resolved after systemic interferon alfa-2a injections. Read More

    Characterization of an orf virus isolate from an outbreak in Heilongjiang province, China.
    Arch Virol 2017 Oct 19;162(10):3143-3149. Epub 2017 Jun 19.
    Virology Laboratory, College of Biological Science and Technology, Heilongjiang Bayi Agricultural University, 2 Xinyang road, Daqing, 163319, China.
    Contagious ecthyma, caused by orf virus (ORFV), is an epitheliotrophic contagious disease with zoonotic implications that mainly affects sheep, goats, wild ruminants, and humans. Recently, a novel ORFV strain, OV/HLJ/04, was successfully isolated from the skin and mucosal lesions of a goat with severe clinical sore mouth symptoms in Heilongjiang province of China. The OV/HLJ/04 isolate was characterized by electron microscopy, serological tests, and experimental reproduction of disease. Read More

    Diagnosis and phylogenetic analysis of a multifocal cutaneous orf virus with mixed bacterial infection outbreak in goats in Fujian province, China.
    Arch Virol 2017 Oct 16;162(10):2997-3006. Epub 2017 Jun 16.
    Department of Laboratory Medicine, School of Stomatology and Medicine, Foshan University, Foshan, 528000, Guangdong, People's Republic of China.
    Outbreaks of orf virus on goat farms are common in China. In this study, we investigated a severe multifocal cutaneous orf virus outbreak with a correlative mixed bacterial infection which persisted for up to 6 months, and which had a high morbidity (93.7%) and mortality (15%) among kids in a herd of crossbreed goats in Fujian province in China. Read More

    Ecthyma Gangrenosum: or ?
    Front Microbiol 2017 30;8:953. Epub 2017 May 30.
    Division of Infectious Diseases, Department of Medical Specialties, Geneva University HospitalsGeneva, Switzerland.
    Ecthyma gangrenosum (EG) are necrotic lesions that develop in the context of bacteremia. Isolated reports describe EG in the setting of non-Pseudomonal infections. In a patient with EG, initial blood cultures showed , and almost occulted bacteremia. Read More

    An Overwiev of ORF Virus Infection in Humans and Animals.
    Recent Pat Antiinfect Drug Discov 2017 ;12(1):21-30
    Department of Infectious Diseases, Faculty of Medicine, Erciyes University, 38039-Kayseri. Turkey.
    Background: Orf virus is a DNA virus that belongs to the Parapoxvirus genus. The virus is a causative agent of orf in humans or contagious ecthyma in animals which is mostly seen in sheep, goat and cattle.

    Discussion: Orf is an emerging zoonosis with an increasing number of worldwide outbreaks that have been reported. Read More

    Pasteurella multocida ecthyma complicated by necrotizing fasciitis.
    Dermatol Online J 2017 Apr 15;23(4). Epub 2017 Apr 15.
    Medical Scientist Training Program, Ohio State University Wexner Medical Center, Columbus, Ohio, Department of Internal Medicine, Division of Dermatology, Ohio State University Wexner Medical Center, Columbus, Ohio.
    Necrotizing fasciitis is a serious infection of the skin and soft tissues. Pasteurella multocida is rarely reported to cause necrotizing fasciitis and is associated with high mortality. We describe a female patient with a past medical history of diabetes mellitus and myeloproliferative disorder presenting with bullae and erythema of the right forearm secondary to P. Read More

    Ecthyma gangrenosum secondary to methicillin-sensitive .
    Int J Womens Dermatol 2016 Sep 22;2(3):89-92. Epub 2016 Jul 22.
    Departments of Medicine (Division of Infectious Diseases) and Dermatology, University of CT Health Center, Farmington, Connecticut.
    Ecthyma gangrenosum (EG) is a well-described skin manifestation of septicemia in immunocompromised patients. However, it can be seen in association with other bacteria, viruses, and fungi. We report a case of a 54-year-old African American female with metastatic gastric adenocarcinoma and recent chemotherapy and neutropenia who developed EG-like lesions due to methicillin-susceptible . Read More

    Orf virus infection.
    Rev Med Virol 2017 Jul 8;27(4). Epub 2017 May 8.
    Dermatology Department, American University of Beirut Medical Center, Beirut, Lebanon.
    Orf virus (ORFV) is an important pathogen responsible for a highly contagious zoonotic viral infection that threatens those who handle sheep and goats. Orf virus is the prototype of the Parapoxvirus genus, and its resilience in the environment and ability to reinfect its host has contributed to the spread and maintenance of the infection in many species. In healthy humans, the disease usually resolves spontaneously within 3 to 6 weeks. Read More

    Acute Cutaneous Necrosis: A Guide to Early Diagnosis and Treatment.
    J Cutan Med Surg 2017 Sep/Oct;21(5):425-437. Epub 2017 May 4.
    4 University of Missouri Kansas City, Department of Internal Medicine, Kansas City, MO, USA.
    Acute cutaneous necrosis is characterised by a wide range of aetiologies and is associated with significant morbidity and mortality, warranting complex considerations in management. Early recognition is imperative in diagnosis and management of sudden gangrenous changes in the skin. This review discusses major causes of cutaneous necrosis, examines the need for early assessment, and integrates techniques related to diagnosis and management. Read More

    Giant Orf on the Nose.
    J Craniofac Surg 2017 May;28(3):e234-e235
    *Department of Otorhinolaryngology, Gaziantep 25 Aralik State Hospital, Gaziantep †National Tularemia Reference Laboratory, Public Health Institution of Turkey, Ankara, Turkey.
    Orf is a zoonotic infectious disease caused by parapoxvirus. Orf lesions are typically seen on the hand, but they have rarely been reported on the nose. Herein, the authors report a rare patient of an orf lesion on the nose of a 52-year-old man after the Muslim celebration of the feast of the sacrifice. Read More

    Identification and phylogenetic analysis of contagious ecthyma virus from camels (Camelus dromedarius) in Iran.
    Onderstepoort J Vet Res 2017 Mar 24;84(1):e1-e5. Epub 2017 Mar 24.
    Department of Pathobiology, Shiraz University.
    Contagious ecthyma is a highly contagious disease affecting domestic and wild ruminants such as sheep, goats and camels. The identification and characterisation of a parapoxvirus (PPV) infecting camels is described here. The virus was detected in dromedary camels (Camelus dromedarius) from Kerman and Shiraz in Iran. Read More

    Genetic characterization of orf virus associated with an outbreak of severe orf in goats at a farm in Lusaka, Zambia (2015).
    Arch Virol 2017 Aug 4;162(8):2363-2367. Epub 2017 Apr 4.
    Department of Disease Control, School of Veterinary Medicine, University of Zambia, PO Box 32379, Lusaka, Zambia.
    Orf or contagious ecthyma is a neglected and economically important zoonotic disease caused by a dermatotropic parapoxvirus that commonly affects domestic small ruminants. Although orf is globally distributed, there is a paucity of information on the disease in many African countries. Here, a suspected severe outbreak of orf in goats at a farm in Lusaka was investigated. Read More

    [Primary immunodeficiencies in seriously ill children: Report of 3 clinical cases].
    Rev Chil Pediatr 2017 02;88(1):136-141
    Unidad de Paciente Crítico Pediátrico, Clínica Santa María, Santiago, Chile.
    Primary immunodeficiency diseases (PID) are congenital disorders secondary to an impaired immune response. Infections, autoimmune disorders, atopy, and lymphoproliferative syndromes are commonly associated with this disorder.

    Objective: To present and discuss 3 infants diagnosed with PID. Read More

    Ecthyma gangrenosum in a 3-month-old, previously healthy infant: A Case Report.
    Medicine (Baltimore) 2017 Mar;96(10):e6244
    aDepartment of Dermatology bDepartment of Urology, The Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang cDepartment of Dermatology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, People's Republic of China.
    Rationale: Ecthyma gangrenosum (EG) is an aggressive cutaneous disease caused by local or systemic infection with Pseudomonas aeruginosa. EG is characterized by cutaneous manifestations ranging from nodule and papule, to necrotic ulceration with surrounding erythema, especially with black eschar or central crust. EG presents with characteristic skin lesions which is important to establish diagnosis of sepsis caused by P aeruginosa, a serious condition that can be treated efficiently if diagnosed early. Read More

    Ecthyma gangrenosum without bacteraemia: evidence in favour of a broader definition.
    Clin Exp Dermatol 2017 Apr 27;42(3):324-327. Epub 2017 Feb 27.
    Department of Dermatology, St George's Hospital, London, UK.
    Ecthyma gangrenosum (EG) is often defined as a cutaneous manifestation of Pseudomonas aeruginosa septicaemia, typically secondary to neutropenia. There is increasing recognition that a broader definition is warranted, as numerous causative organisms and predisposing conditions have been reported. We describe two cases of EG that occurred without bacteraemia. Read More

    Identification and characterization of Orf virus 050 protein proteolysis.
    Virus Genes 2017 Jun 11;53(3):400-409. Epub 2017 Feb 11.
    Department of Laboratory Medicine, The Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510120, Guangdong, People's Republic of China.
    The Orf virus 050 (ORFV050) gene is located in the core region of the ORFV genome. It is similar to Vaccinia virus (VV) Copenhagen L4R, and encodes the DNA-binding virion core protein VP8, which has structures similar to the VV P25K core protein and may undergo similar proteolytic processing during virus assembly. Three conserved Ala-Gly-X motifs at putative cleavage sites were identified in ORFV050. Read More

    [Mucormycosis cutanea- clinical case presentation souvenir etiopatogenia diagnosis and treatment].
    Rev Fac Cien Med Univ Nac Cordoba 2016 ;73(4):302-305
    Unidad de Terapia Intensiva; Mario López Bravo.
    Mucormycosis is serious emerging infection, caused by saprophytic fungi of the order Mucorales, which mainly affects immunocompromised patients. Presentation forms can be rinosinusal, pulmonary, gastrointestinal, disseminated and localized wounds and burns. The cutaneous presentation is caused by inoculation of spores into the dermis with the subsequent development compatible with gangrenous ecthyma. Read More

    A single black ulcer in a child with acute lymphocytic leukemia.
    An Bras Dermatol 2016 Nov-Dec;91(6):815-816
    University of Bari - Bari, Italy.
    Ecthyma gangrenosum is an uncommon dermatological manifestation characterized by round, indurated ulcers with a central necrotic black eschar and surrounding erythema. This report describes the case of a 5-year-old girl, affected by acute lymphocytic leukemia, presenting with a black eschar on her right thigh. Such lesions should always be correctly identified to avoid potentially fatal bacteraemia. Read More

    DISEASE COMPLEXITY IN A DECLINING ALASKAN MUSKOX (OVIBOS MOSCHATUS) POPULATION.
    J Wildl Dis 2017 Apr 18;53(2):311-329. Epub 2017 Jan 18.
    1   Wildlife Health Center, One Health Institute, School of Veterinary Medicine, University of California, 1089 Veterinary Medicine Drive, Davis, California 95616, USA.
    The muskox ( Ovibos moschatus ) population inhabiting the eastern North Slope (ENS) of Alaska, US declined dramatically during 1999-2006, whereas populations in western Alaska (WA) were stable or increasing. To understand morbidity and mortality factors contributing to the decline, Alaska Department of Fish and Game conducted pathologic investigations of carcasses from 2005 until 2008. Additionally, archived sera from both ENS and WA muskoxen collected during 1984-92, before the documented beginning of the ENS decline; sera collected during 2000, near the beginning of the decline; and contemporary sera (from live capture-release, adult females) collected during 2006, 2007, and 2008 were analyzed to determine whether prevalence of antibody to potential pathogens differed in the two areas or changed over time. Read More

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