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CMAJ 2022 Jun;194(24):E861-E862

Département de médecine, Université Oregon Health & Science, Portland, Oregon.

Ann Dermatol Venereol 2022 Jun 13. Epub 2022 Jun 13.

Service des maladies infectieuses, dermatologie, CHU La Réunion, 97448 Saint-Pierre Cedex, Reunion; Inserm CIC1410, CHU La Réunion, 97448 Saint-Pierre Cedex, Reunion.

SAGE Open Med Case Rep 2022 25;10:2050313X221102113. Epub 2022 May 25.

Department of Clinical Haematology, National Institute of Blood Diseases and Bone Marrow Transplantation, Karachi, Pakistan.

Pseudomonal ecthyma gangrenosum is a well-known condition in immunosuppressed patients. However, ecthyma gangrenosum associated with is a rare entity that requires early recognition and optimal antibiotic and surgical management. We herein report the first case of colistin & carbapenem-resistant ecthyma gangrenosum in an acute myeloid leukemia patient. Read More

An Bras Dermatol 2022 May 30. Epub 2022 May 30.

Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.

Rev Med Interne 2022 May 24. Epub 2022 May 24.

Service de médecine interne, Centre Hospitalier Intercommunal Elbeuf Louviers Val de Reuil, Saint Aubin Lès Elbeuf, France.

Open Vet J 2022 Mar-Apr;12(2):273-280

The Veterinary Clinic, Faculty of Veterinary Medicine, Zagazig University, El-Shohada, Moawwad, Qesm Awel AZ Zagazig, 44519, Egypt.

Background: Orf is a highly contagious viral skin disease in sheep and goats caused by Orf virus (ORFV) in the genus Parapoxvirus. Although sheep and goats are considered an essential food resource, particularly in Africa, ORFV infection represents an increasing challenge to animal productivity causing high economic losses.

Aim: This study aimed to detect and characterize the ORFV in suspected clinically diseased goats in two neighboring Egyptian governorates, Al-Sharkia and Ismailia, flocks during April 2020 and July 2021by using PCR and phylogenetic analysis of partial B2L sequence. Read More

Germs 2022 Mar 31;12(1):118-123. Epub 2022 Mar 31.

MD, Microbiologist, Department of Microbiology, Faculty of Medicine, Pelita Harapan University, Banten, 15811, Indonesia.

Introduction: Ecthyma gangrenosum (EG) is a rare cutaneous manifestation commonly associated with infection in immunocompromised individuals. Additionally, different bacterial and fungal pathogens have also been identified. However, co-infection on EG lesions has never been reported before. Read More

Case Rep Vet Med 2022 5;2022:1598256. Epub 2022 May 5.

Department of Paraclinical Studies, Faculty of Veterinary Medicine, Universiti Malaysia Kelantan, Pengkalan Chepa, 16100 Kota Bharu, Kelantan, Malaysia.

The clinical management and outcome of a case of caprine papillomatosis in a 2-week-old kid goat was reported. Based on the PCR result, contagious ecthyma (CE) was ruled out. Based on the history and physical examination findings, the case was diagnosed as severe clinical case of papillomatosis in a goat's kid. Read More

Arch Virol 2022 Jul 14;167(7):1577-1582. Epub 2022 May 14.

Division of Virology, ICAR-Indian Veterinary Research Institute, Nainital District, Mukteswar, Uttarakhand, 263138, India.

In the present study, we analyzed the chemokine-binding protein (CBP) and the GM-CSF/IL-2 inhibition factor (GIF) of orf virus (ORFV) isolates of sheep and goat origin from different geographical regions of India. Both are immunomodulatory proteins known for their unique strategy of establishing short-term immunity and re-infection in their host. The GIF gene is highly conserved, whereas the CBP gene is highly variable. Read More

Arch Virol 2022 Jul 11;167(7):1571-1576. Epub 2022 May 11.

Department of Biological Science, Indian Institute of Science Education and Research (IISER) Bhopal, Bhopal Bypass Road, Bhauri, Madhya Pradesh, 462066, India.

Contagious pustular dermatitis is a disease that primarily infects small ruminants and possesses zoonotic potential. It is caused by orf virus (ORFV), a member of the genus Parapoxvirus. In this study, we evaluated an ORFV outbreak in goats in Madhya Pradesh, a state in central India, during 2017. Read More

J Dermatol 2022 Apr 19. Epub 2022 Apr 19.

Department of Dermatology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan.

Pediatr Neonatol 2022 Mar 26. Epub 2022 Mar 26.

Department of Paediatrics, Women and Children Hospital Kuala Lumpur, 50586 Jalan Pahang, Kuala Lumpur, Malaysia.

Pathologe 2022 Apr 4. Epub 2022 Apr 4.

Institut für Medizinische Genetik und Pathologie, Universitätsspital Basel, Schönbeinstrasse 40, 4031, Basel, Schweiz.

A case of a patient suffering from COVID-19 with suspected associated myositis is reported, in which the initially limited information about the history and disease course led to difficulties in establishing a reasonable diagnosis. Through inquiry, further data could be collected, so that the diagnosis of an infection-associated thrombotic microangiopathy in the context of a Morganella morganii myositis could be made. This patient study shows that even in times of the omnipresent pandemic and despite the context of a positive COVID-19 test result, differential diagnoses and the integrative clinicopathologic approach in interpreting muscle biopsy findings should not be neglected. Read More

JAMA Dermatol 2022 Jun;158(6):670-674

Department of Dermatology, University of Lübeck, Lübeck, Germany.

Importance: Ecthyma contagiosum, or orf, is a viral zoonotic infection caused by Poxviridae. Although human orf infection is considered to follow a self-limited course, various immunological reactions may be triggered, including immunobullous diseases. In the majority of the latter cases, the antigenic target remained enigmatic. Read More

CMAJ 2022 03;194(12):E461

Department of Medicine, Oregon Health & Science University, Portland, Ore.

Eur J Clin Microbiol Infect Dis 2022 May 23;41(5):779-786. Epub 2022 Mar 23.

Instituto de Investigación Biomédica Gregorio Marañón, Madrid, Spain.

Cutaneous manifestations developed in the course of sepsis are poorly documented in the medical literature beyond those related to specific pathogens or classical clinical pictures such as purpura fulminans or ecthyma gangrenosum. The objective of this study was to determine the overall prevalence of sepsis-related skin findings and evaluate their possible impact on the prognosis of septic patients. Single-centre, retrospective study of septic patients with documented bloodstream infections admitted in a tertiary hospital during 2019. Read More

BMJ Case Rep 2022 03 22;15(3). Epub 2022 Mar 22.

Infectious Diseases and Immunodeficiency Unit, Pediatrics Department, Hospital de Santa Maria, Lisboa, Portugal.

North Clin Istanb 2021 18;8(6):626-628. Epub 2021 Nov 18.

Department of Dermatology, Medeniyet University Faculty of Medicine, Goztepe Training and Research Hospital, Istanbul, Turkey.

Orf, ecthyma contagiosum, is a zoonotic viral infectious disease caused by parapoxvirus that affects particularly sheep and goats. Human may be infected with direct contact with contagious animals or by handling contaminated animal products. Lesions are localized mostly on the hands and fingers, but atypical localizations such as head or face have been rarely reported. Read More

Cureus 2022 Jan 14;14(1):e21225. Epub 2022 Jan 14.

Department of Pulmonology, Laiko General Hospital, Athens, GRC.

Ecthyma gangrenosum (EG) is an uncommon necrotizing vasculitis that affects mainly immunocompromised and burn patients, and it is frequently associated with bacteremia. However, cases of EG with other related pathogens and cases of EG affecting immunocompetent hosts have also been described in the literature. Besides, less common cases of EG without bacteremia have been reported. Read More

Rev Prat 2021 Oct;71(8):872

Service de dermatologie, vénérologie et allergologie, CHU Mohammed-VI, Oujda, Maroc - Laboratoire d'épidémiologie, de recherche clinique et de santé publique, faculté de médecine et de pharmacie Oujda, Université Mohammed Premier Oujda, Maroc.

Infect Genet Evol 2022 03 20;98:105220. Epub 2022 Jan 20.

College of Biological Science and Technology, Heilongjiang Bayi Agricultural University, Daqing 163319, PR China.

Poxviruses are a family of specialized cytoplasm-parasitic DNA viruses that replicate and assembly in virus factory. In Parapoxvirus (PPV) genus, with the orf virus (ORFV) as a representative species of this genus, their behaviors are significantly different from that of Orthopoxvirus, and the plots of viral practical solutions for evading host immunity are intricate and fascinating, particularly to anti-host and host's antiviral mechanisms. In order to protect the virus factory from immune elimination caused by infection, PPVs attempt to interfere with multiple stress levels of host, mainly by modulating innate immunity response (IIR) and adaptive immunity response (AIR). Read More

Sports Health 2022 Jan 17:19417381211065026. Epub 2022 Jan 17.

Department of Dermatology, Mayo Clinic, Jacksonville, Florida.

Context: Athletes are a unique group of patients whose activities, particularly in high-contact sports such as wrestling and football, place them at high risk of developing skin conditions. The correct diagnosis of sports dermatoses requires familiarity with their clinical characteristics. It is critical that primary care physicians recognize the most common skin disorders to provide prompt treatment and prevent transmission. Read More

Life Sci 2022 Feb 8;291:120297. Epub 2022 Jan 8.

Institute of Antibody Engineering, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou 510515, Guangdong, PR China; Key Laboratory of Antibody Engineering of Guangdong Higher Education Institutes, Southern Medical University, Guangzhou 510515, Guangdong, PR China. Electronic address:

Aims: Orf virus (ORFV) is a parapoxvirus causing contagious ecthyma in sheep and goats. With inhibitory role of ORFV reported by previous studies, ORFV can be a candidate of oncolytic virus. However, few studies reported the application and mechanism of ORFV in nasopharyngeal carcinoma (NPC). Read More

Am J Dermatopathol 2022 Apr;44(4):279-281

Department of Dermatology, University of Nebraska Medical Center, Omaha, NE.

Abstract: In this brief report, we describe a 16-year-old patient with pre-B-cell acute lymphoblastic leukemia on chemotherapy who presented to the emergency department with a fever and "bruise-like" area on his left forearm. Empiric antibiotic therapy was initiated, and initial tissue biopsy demonstrated findings consistent with ecthyma gangrenosum. On day 4 of admission, initial blood cultures grew Moraxella nonliquefaciens, and targeted antibiotic therapy was initiated and continued for a total of 21 days. Read More

Vet Dermatol 2022 Jun 27;33(3):227-e64. Epub 2021 Dec 27.

Department of Population Health & Reproduction, School of Veterinary Medicine, University of California, Davis, CA, 95616, USA.

Background: Goats are important worldwide as a source of milk, meat, fibre and hide, and as show animals and pets.

Hypothesis/objectives: To document the type, signalment associations and prevalence of skin disease in a referral hospital population.

Animals: Case population at a university veterinary teaching hospital. Read More

JAC Antimicrob Resist 2021 Dec 11;3(4):dlab188. Epub 2021 Dec 11.

Department of Infectious Diseases, Azienda Ospedaliero-Universitaria of Modena, Modena, Italy.

Objectives: To describe our real-life experience with cefiderocol in XDR and difficult-to-treat resistant (DTR-P) infections without any other available treatment options.

Methods: We included patients with a proven infection due to an XDR/DTR-P, who had failed on previous regimens, and were treated with cefiderocol, following them prospectively to day 90 or until hospital discharge or death.

Results: Seventeen patients treated for >72 h with cefiderocol were included: 14 receiving combination regimens (82. Read More

J Pediatr 2022 Apr 1;243:236-237. Epub 2021 Dec 1.

Department of Paediatrics, Fribourg Hospital HFR, Fribourg, Switzerland; Faculty of Science and Medicine, University of Fribourg, Fribourg, Switzerland.

Microorganisms 2021 Oct 20;9(11). Epub 2021 Oct 20.

Istituto Zooprofilattico Sperimentale della Puglia e della Basilicata, Via Manfredonia 20, 71100 Foggia, Italy.

ORF virus (Poxviridae) is the causative agent of contagious ecthyma (soremouth), a disease primarily affecting sheep and goats worldwide, but also humans exposed to disease-ridden animals. Pathogens are shed with scabs, and infection mainly occurs by direct contact. Although the disease is relatively benign and self-limiting, the morbidity rate is high in livestock with subsequent significant financial and economic impact. Read More

Vaccines (Basel) 2021 Nov 17;9(11). Epub 2021 Nov 17.

Department of Pathology and Microbiology, Faculty of Veterinary Medicine, Universiti Putra Malaysia, Serdang 43400, Selangor, Malaysia.

Orf virus (ORFV), the prototype species of the parapoxvirus genus, is the causative agent of contagious ecthyma, an extremely devastating skin disease of sheep, goats, and humans that causes enormous economic losses in livestock production. ORFV is known for its ability to repeatedly infect both previously infected and vaccinated sheep due to several immunomodulatory genes encoded by the virus that temporarily suppress host immunity. Therefore, the development of novel, safe and effective vaccines against ORFV infection is an important priority. Read More

Pediatr Allergy Immunol 2022 01 18;33(1):e13666. Epub 2021 Nov 18.

Division of Pediatric Oncology, Department of Pediatrics, Hacettepe University, Ankara, Turkey.