36,620 results match your criteria Eclampsia


Headache in Pregnancy, the Puerperium, and menopause.

Semin Neurol 2018 Dec 6;38(6):627-633. Epub 2018 Dec 6.

Department of Neurology, University at Buffalo School of Medicine and Biomedical Sciences, The State University of New York, Buffalo, New York.

Headache is a neurologic disorder that displays gender dichotomy. It is well established that there is a strong link between migraine headache and sex hormones, specifically estrogen, which influences the severity of migraines during the menstrual cycle, pregnancy, and menopause. Furthermore, the epidemiology of headaches during pregnancy and the postpartum period is very distinct from that in males or nonpregnant females, in part due to the hemodynamic and hematologic changes that occur during pregnancy. Read More

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December 2018
1 Read

Maternal and perinatal outcomes of expectant treatment of severe preeclampsia

Rev Med Inst Mex Seguro Soc 2018 11 30;56(4):379-386. Epub 2018 Nov 30.

Instituto Mexicano del Seguro Social, Hospital de Ginecología y Obstetricia No. 3 “Dr. Víctor Manuel Espinoza de los Reyes Sánchez”, Unidad de Cuidados Intensivos. Ciudad de México, México

Background: In severe preeclampsia (SP), pregnancy interruption is the first recommendation. However, some patients receive expectant treatment.

Objetive: To determine maternal and perinatal results of expectant treatment of SP in the intensive care unit (ICU) of a high-specialty hospital. Read More

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November 2018
1 Read

Association of pre-eclampsia risk with maternal levels of folate, homocysteine and vitamin B12 in Colombia: A case-control study.

PLoS One 2018 6;13(12):e0208137. Epub 2018 Dec 6.

Farr Institute of Health Informatics, University College London, London, United Kingdom.

Background: Maternal serum concentrations of folate, homocysteine, and vitamin B12 have been associated with pre-eclampsia. Nevertheless, reported studies involve limited number of cases to reliably assess the nature of these associations. Our aim was to examine the relation of these three biomarkers with pre-eclampsia risk in a large Colombian population. Read More

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December 2018

[Morbidity in Prematurity Associated with Fetal Growth Restriction: Experience of a Tertiary Care Center].

Acta Med Port 2018 Nov 30;31(11):648-655. Epub 2018 Nov 30.

Serviço de Neonatologia. Departamento de Pediatria. Hospital Universitário de Santa Maria. Centro Hospitalar Lisboa Norte. Lisboa. Clínica Universitária de Pediatria. Faculdade de Medicina. Universidade de Lisboa. Lisboa. Portugal.

Introduction: Prematurity and low birth weight have been associated with increased neonatal morbidity and mortality. This study aimed to evaluate possible risk factors for prematurity associated with fetal growth restriction and being small for gestational age and to determine the incidence of morbidity in these two groups of infants.

Material And Methods: Retrospective case-control study of newborns with gestational age of less than 32 weeks, with obstetric diagnosis of fetal growth restriction and with the clinical diagnosis of small for gestational age, admitted to the Neonatal Intensive Care Unit of a tertiary hospital for a period of six years. Read More

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November 2018

Brachial and uterine arteries Doppler in healthy women and with preeclampsia

Rev Med Inst Mex Seguro Soc 2018 11 30;56(4):360-363. Epub 2018 Nov 30.

Instituto Mexicano del Seguro Social, Hospital de Gineco Obstetricia No. 4 "Luis Castelazo Ayala", División de Investigación en Salud. Ciudad de México, México

Objective: To compare the Doppler ultrasound parameters of the uterine and brachial arteries, between healthy pregnant women and pregnant women with preeclampsia.

Methods: 102 pregnant women were studied in the third trimester, group I 83 healthy women and group II 19 patients with severe preeclampsia. All of them underwent Doppler ultrasound of the uterine arteries, measuring the pulsatility index (PI) and determining the presence of proto-diastolic notch. Read More

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November 2018

Assessing the effect of dexmedetomidine in patients with pre-eclampsia.

Eur J Anaesthesiol 2019 Jan;36(1):75

From the Department of Anaesthesiology, The Affiliated Hospital of Guizhou Medical University, Guiyang, China (BH, XZ, JS), and Department of Clinical Research Centre, The Affiliated Hospital of Guizhou Medical University, Guiyang, China (HZ).

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January 2019

Profound bilateral post-partum retinal circulation ischemia in two diabetic mothers with pre-eclampsia.

Am J Ophthalmol Case Rep 2019 Mar 10;13:28-31. Epub 2018 Nov 10.

Howard University, 2041 Georgia Avenue NW, Washington DC, USA.

Purpose: We report 2 cases of young diabetic mothers with pre-eclampsia and no previously documented visual deficits prior to pregnancy who were found to have profound retinal circulation loss during the postpartum period.

Observations: Fluorescein angiogram in both cases documented profound ischemia of retinal and macular circulation with resulting severe vision loss, leading to legal blindness.

Conclusions And Importance: While Pre-eclampsia and Eclampsia are well known clinical entities with potentially grave effects on both the mother and child, there is little information about the possible combined effects of diabetes and Pre-eclampsia/Eclampsia on the retinal circulation. Read More

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Maternal psychological distress after severe pregnancy hypertension was associated with increased child behavioural problems at the age of 12.

Acta Paediatr 2018 Dec 1. Epub 2018 Dec 1.

Department of Neonatology, Emma Children's Hospital, Academic Medical Center, Amsterdam, Netherlands.

Aim: We examined the association between early maternal psychological distress after severe hypertensive disorders of pregnancy (HDP) and behavioural issues in their 12-year-old offspring.

Methods: This secondary analyses of a prospective mother-child birth cohort focused on 95 women with severe HDP and their singleton offspring. The mothers were recruited during pregnancy from 2000 to 2003 in Amsterdam, The Netherlands. Read More

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December 2018

Status epilepticus related to pregnancy: Devising a protocol for use in the intensive care unit.

Neurol India 2018 Nov-Dec;66(6):1629-1633

Department of Neurology, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Thiruvananthapuram, Kerala, India.

Background: Status epilepticus (SE) related to pregnancy is rare and carries a significant risk to both the mother and the fetus.

Objectives: We conducted this study to devise a protocol for the management of SE related to pregnancy in a cohort of female patients admitted with SE during pregnancy.

Materials And Methods: All women who developed SE related to pregnancy (gestation, labor, and puerperium) between January 2000 and December 2016 were included. Read More

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December 2018

Placental thickness on ultrasound and neonatal birthweight.

J Perinat Med 2018 Dec 3. Epub 2018 Dec 3.

Penn State Hershey Medical Center, Division of Maternal Fetal Medicine, Hershey, PA, USA.

Objective To investigate the relationship between maximal placental thickness during routine anatomy scan and birthweight at delivery. Methods This retrospective descriptive study analyzed 200 term, singleton deliveries in 2016 at Penn State Hershey Medical Center. We measured maximal placental thickness in the sagittal plane from the ultrasound images of the placenta obtained at the 18-21-week fetal anatomy screen. Read More

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December 2018

High Sensitivity Cardiac Troponin I Levels in Normal Pregnancy And When Complicated By Hypertension.

Am J Med 2018 Nov 29. Epub 2018 Nov 29.

Mayo Clinic, Rochester, MN, USA. Electronic address:

Objective: To examine the association of circulating concentrations of high-sensitivity cardiac troponin I (hs-Tn) in the various trimesters of pregnancy in patients with and without hypertension.

Method: Prospective cross-sectional study of pregnant and post-natal women aged between 18-35 years of age with no coexisting disease. Serum samples were analysed for hs-TnI. Read More

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November 2018

Effect of Ethanol Extract on the Nitric Oxide Content and Renal Arteriole Diameter of a Pre-eclampsia Mouse Model.

Eurasian J Med 2018 Oct;50(3):148-151

Laboratory of Parasitology, Brawijaya University School of Medicine, Malang, East Java, Indonesia.

Objective: The aim of this study was to investigate the effect of Nigella sativa ethanol extract on nitric oxide (NO) levels and renal arteriole diameter of a pre-eclampsia mouse model.

Materials And Methods: This experimental study was conducted using a post-test only control group design. Thirty BALB/c mice were divided into six groups: one negative control (normal pregnant mice), one positive control (pre-eclampsia model), and four groups of pre-eclampsia mice treated with varying doses of N. Read More

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October 2018

A novel RNA interference approach to targeting sFLT1 in pre-eclampsia.

Authors:
Ellen F Carney

Nat Rev Nephrol 2018 Dec 4. Epub 2018 Dec 4.

Nature Reviews Nephrology, .

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December 2018
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Metabolic syndrome in pregnancy and risk for adverse pregnancy outcomes: A prospective cohort of nulliparous women.

PLoS Med 2018 Dec 4;15(12):e1002710. Epub 2018 Dec 4.

Robinson Research Institute, University of Adelaide, Adelaide, Australia.

Background: Obesity increases the risk for developing gestational diabetes mellitus (GDM) and preeclampsia (PE), which both associate with increased risk for type 2 diabetes mellitus (T2DM) and cardiovascular disease (CVD) in women in later life. In the general population, metabolic syndrome (MetS) associates with T2DM and CVD. The impact of maternal MetS on pregnancy outcomes, in nulliparous pregnant women, has not been investigated. Read More

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December 2018

Characteristics and Outcome of Obstetric Acute Kidney Injury in Pakistan: A Single-center Prospective Observational Study.

Cureus 2018 Sep 26;10(9):e3362. Epub 2018 Sep 26.

Nephrology, Allama Iqbal Medical College, Lahore, PAK.

Introduction Acute kidney injury (AKI) continues to be a cause of increased morbidity and mortality in pregnant women. While studies have been conducted on the incidence and etiology of this complication, the outcomes of obstetric AKI have not been extensively investigated. The primary focus of this prospective observational study was to analyze the risk factors, etiologies as well as maternal and fetal outcomes of AKI in pregnant females in Pakistan. Read More

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September 2018
3 Reads

Atypical Hemolytic Uremic Syndrome Presenting as Pre-eclampsia in a 24-year-old Woman with Chronic Kidney Disease: Pathogenesis and Genetics.

Cureus 2018 Sep 25;10(9):e3358. Epub 2018 Sep 25.

Internal Medicine, Brookdale University Hospital, New York, USA.

Atypical hemolytic uremic syndrome (aHUS) is a kidney disorder that is frequently unrecognized during its progression, and misdiagnosed with more common etiologies of microangiopathic hemolytic anemia (MAHA): hemolytic uremic syndrome, disseminated intravascular coagulation, and thrombotic thrombocytopenic purpura (TTP). During pregnancy, the diagnosis of aHUS is furthermore challenging. The clinical presentation of aHUS may mimic pre-eclampsia as it occurred to the patient described in the case report. Read More

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September 2018

The association between vascular complications during pregnancy in women with Type 1 diabetes and congenital malformations.

Diabet Med 2018 Nov 30. Epub 2018 Nov 30.

Departments of Medicine, University of Calgary, Calgary Alberta, Canada.

Aims: To assess the association between vascular complications of diabetes and the risk of congenital malformations in pregnant women with Type 1 diabetes.

Methods: We conducted an observational retrospective cohort study in women with Type 1 diabetes who received care consecutively from three tertiary care diabetes-in-pregnancy clinics in Calgary, Alberta, Canada. Multivariable logistic regression was used to assess the association between vascular complications (retinopathy, nephropathy and pre-existing hypertension) and congenital malformations in offspring of women with Type 1 diabetes. Read More

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November 2018

Chronic renal disease and antenatal care.

Authors:
Matt Hall

Best Pract Res Clin Obstet Gynaecol 2018 Oct 30. Epub 2018 Oct 30.

Nottingham Renal and Transplant Unit, City Campus, Nottingham University Hospitals, Hucknall Road, Nottingham, NG5 1PB, UK. Electronic address:

In 2018, it is unusual for women with chronic kidney disease (CKD) to be told that pregnancy is not an option. Maternal and foetal outcomes have steadily improved over the last 50 years and a successful pregnancy, resulting in a healthy infant without detrimental to maternal health, is commonplace. Nevertheless, the incidence of adverse outcomes including pre-eclampsia, preterm birth and small-for-gestational age infants is higher for women with CKD than the general population, requiring enhanced monitoring. Read More

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October 2018

Obstructive sleep apnea as a risk factor for preeclampsia-eclampsia.

Sleep Breath 2018 Nov 27. Epub 2018 Nov 27.

Department of Obstetrics and Gynecology, Maharat Nakhon Ratchasima Hospital, Amphoe Mueang Nakhon Ratchasima, Nakhon Ratchasima Province, Thailand.

Purpose: Preeclampsia-eclampsia remains one of the leading causes of maternal and perinatal morbidity and mortality. Emerging evidence suggests that obstructive sleep apnea (OSA), which has been linked to hypertension in the general population, may play role in hypertensive disorders in pregnancy, including preeclampsia-eclampsia. However, little research has been conducted in Asia (no data in Thailand) on the effects of OSA on preeclampsia-eclampsia. Read More

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November 2018
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Omega-3 fatty acid addition during pregnancy.

Cochrane Database Syst Rev 2018 Nov 15;11:CD003402. Epub 2018 Nov 15.

Healthy Mothers, Babies and Children, South Australian Health and Medical Research Institute, Women's and Children's Hospital, 72 King William Road, Adelaide, South Australia, Australia, 5006.

Background: Higher intakes of foods containing omega-3 long-chain polyunsaturated fatty acids (LCPUFA), such as fish, during pregnancy have been associated with longer gestations and improved perinatal outcomes. This is an update of a review that was first published in 2006.

Objectives: To assess the effects of omega-3 LCPUFA, as supplements or as dietary additions, during pregnancy on maternal, perinatal, and neonatal outcomes and longer-term outcomes for mother and child. Read More

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November 2018
7 Reads

Influential factors and clinical significance of an atypical presentation of posterior reversible encephalopathy syndrome in patients with eclampsia.

Neurol Sci 2018 Nov 26. Epub 2018 Nov 26.

Department of Neurology, Shengjing Hospital of China Medical University, 36 Sanhao Street, Heping District, Shenyang, 110004, Liaoning, People's Republic of China.

Background And Purpose: Posterior reversible encephalopathy syndrome (PRES) is a clinical and radiologic entity for which eclampsia is one of the most common predisposing conditions. Despite the imaging changes typically reported, the predisposing factors and clinical implications of atypical presentations have yet to be fully clarified.

Methods: A total of 56 patients with PRES were selected for study. Read More

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November 2018

Pregnancy outcomes following nonobstetric surgery during gestation: a nationwide population-based case-control study in Taiwan.

BMC Pregnancy Childbirth 2018 Nov 26;18(1):460. Epub 2018 Nov 26.

Division of Women's and Children's Anesthesia, Department of Anesthesiology, Chi Mei Medical Center, 901 Zhonghua Road, Yongkang District, Tainan City, 710, Taiwan.

Background: Whether nonobstetric surgery during gestation is associated with a higher risk of spontaneous abortion or adverse delivery outcomes is still unclear.

Methods: We performed a retrospective case-control study using a Longitudinal Health Insurance Database (LHID 2000) containing claim-data of 1 million randomly selected beneficiaries. We compared the incidences and estimated the adjusted odds ratios (aOR) with 95% confidence interval (95% CI) for spontaneous abortion, adverse delivery outcomes, cesarean delivery, and prolonged hospital stay to determine the risk of adverse outcomes in women who had nonobstetric surgery during gestation as compared to those who did not have any surgery during gestation. Read More

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November 2018
2 Reads

Postpartum hemorrhage: incidence, risk factors, and causes in Western French Guiana.

J Gynecol Obstet Hum Reprod 2018 Nov 23. Epub 2018 Nov 23.

Department of Public Health, Centre Hospitalier de l'Ouest Guyanais, Saint-Laurent du Maroni, French Guiana; INSERM, Sorbonne Université, Institut Pierre Louis d'Epidémiologie et Santé Publique, Department of Social Epidemiology, Paris, France.

Introduction: Postpartum hemorrhage remains the leading cause of maternal death in France. Parturients in western French Guiana have specific sociodemographic features and a high rate of pathological pregnancies. The objective of this study was to determine the incidence of immediate postpartum hemorrhage (IPPH) in western French Guiana, and to describe the etiologies and risk factors. Read More

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November 2018
6 Reads

The association between maternal methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C polymorphism and birth defects and adverse pregnancy outcomes.

Prenat Diagn 2018 Nov 25. Epub 2018 Nov 25.

Personalized Drug Therapy Key Laboratory of Sichuan Province, Sichuan Academy of Medical Sciences & Sichuan Provincial PeopleꞋs Hospital, Chengdu, Sichuan, P.R.China.

Published studies indicate the MTHFR C677T and A1298C polymorphisms are associated with abnormal homocysteine levels, which may cause various pregnancy complications and birth defects. However, the results obtained from different studies have been inconsistent. Therefore, this meta-analysis explores the association between MTHFR polymorphisms and birth defects and adverse pregnancy outcomes. Read More

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November 2018
1 Read

Risk of Adverse Maternal and Fetal Outcomes during Pregnancy in Living Kidney Donors: A Matched Cohort Study.

Clin Transplant 2018 Nov 25:e13453. Epub 2018 Nov 25.

Division of Renal Diseases and Hypertension, University of Colorado School of Medicine, Aurora, CO.

Background: We examined the risk of adverse pregnancy outcomes in primiparous kidney donors compared to matched controls.

Methods: Fifty-nine women with a history of kidney donation prior to their first pregnancy with normal renal function and no history of kidney disease, diabetes or chronic hypertension were matched 1:4 by age (within 2 years) and race to women with two kidneys using data from an integrated healthcare delivery system. Adverse pregnancy outcomes were defined as preterm delivery (delivery < 37 weeks), delivery via cesarean section, gestational hypertension, preeclampsia/eclampsia, gestational diabetes, length of stay in the hospital > 3 days, infant death/transfer to acute facility and low birth weight (<2,500 gm). Read More

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November 2018
1 Read

Neuro-Ophthalmic Disorders in Pregnancy.

Neurol Clin 2019 Feb;37(1):85-102

Department of Neurology, Brigham and Women's Hospital, 60 Fenwood Road, Boston, MA 02115, USA; Department of Ophthalmology, Massachusetts Eye and Ear, 243 Charles Street, Boston, MA 02114, USA. Electronic address:

The physiologic changes that accompany pregnancy can have important implications for neuro-ophthalmic disease. This article discusses pregnancy-related considerations for meningioma, pituitary disorders, demyelinating disease, myasthenia gravis, thyroid eye disease, idiopathic intracranial hypertension, cerebral venous sinus thrombosis, stroke, migraine, and cranial neuropathies. The article also details the potential neuro-ophthalmic complications of preeclampsia and eclampsia and reviews the use of common diagnostic studies during pregnancy. Read More

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February 2019
2 Reads

Management of Myasthenia Gravis in Pregnancy.

Authors:
Janet Waters

Neurol Clin 2019 Feb;37(1):113-120

Women's Neurology, University of Pittsburgh Medical Center, 3471 Fifth Avenue Suite 810, Pittsburgh, PA 15213, USA. Electronic address:

Myasthenia gravis is an autoimmune disorder characterized by fluctuating weakness of extraocular and proximal limb muscles. It occurs in 1 in 5000 in the overall population and is 2 times more common in women than men. The onset in women is most common in the third decade, and risk of severe exacerbation occurs most frequently in the year after presentation. Read More

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February 2019
3 Reads

Imaging Considerations in Pregnancy.

Neurol Clin 2019 Feb;37(1):1-16

Department of Radiology, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA. Electronic address:

Pregnancy is a complex physiologic state with hormonal, hemodynamic, hematologic, and immunologic changes at both global and cellular levels affecting brain, heart, pituitary, thyroid, and kidney. There are many situations in which imaging can aid in diagnosis and subsequent treatment of neurologic conditions during pregnancy. Read More

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February 2019
2 Reads

Selenium, Selenoproteins, and Female Reproduction: A Review.

Molecules 2018 Nov 22;23(12). Epub 2018 Nov 22.

Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, China.

Selenium (Se) is an essential micronutrient that has several important functions in animal and human health. The biological functions of Se are carried out by selenoproteins (encoded by twenty-five genes in human and twenty-four in mice), which are reportedly present in all three domains of life. As a component of selenoproteins, Se has structural and enzymatic functions; in the latter context it is best recognized for its catalytic and antioxidant activities. Read More

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November 2018
3 Reads

Measurement of the total angiotensinogen and its reduced and oxidised forms in human plasma using targeted LC-MS/MS.

Anal Bioanal Chem 2018 Nov 21. Epub 2018 Nov 21.

Centre for Analytical Bioscience, Advanced Materials and Healthcare Technologies Division, School of Pharmacy, University of Nottingham, University Park, Nottingham, NG7 2RD, UK.

Angiotensinogen (AGT) is a critical protein in the renin-angiotensin-aldosterone system and may have an important role in the pathogenesis of pre-eclampsia. The disulphide linkage between cysteines 18 and 138 has a key role in the redox switch of AGT which modulates the release of angiotensin I with consequential effects on blood pressure. In this paper, we report a quantitative targeted LC-MS/MS method for the reliable measurement of the total AGT and its reduced and oxidised forms in human plasma. Read More

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November 2018
2 Reads

Risk factors for maternal mortality associated with eclampsia presenting at a Nigerian tertiary hospital.

Int J Womens Health 2018 6;10:715-721. Epub 2018 Nov 6.

Department of Obstetrics and Gynaecology, Lagos State University Teaching Hospital, Ikeja, Lagos State, Nigeria.

Background: Eclampsia remains a leading contributor to maternal mortality, particularly in developing countries, and remains a challenge even to the most experienced obstetrician. We aimed to determine the factors associated with maternal mortality in eclamptics at the Lagos State University Teaching Hospital (LASUTH), Nigeria, in order to suggest ways to prevent this avoidable tragedy.

Materials And Methods: Data were prospectively collected with the aid of a specially designed proforma from January 1, 2011 to December 31, 2012. Read More

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November 2018

Hydralazine HCl rapidly disintegrating sublingual tablets: simple dosage form of higher bioavailability and enhanced clinical efficacy for potential rapid control on hypertensive preeclampsia.

Drug Des Devel Ther 2018 5;12:3753-3766. Epub 2018 Nov 5.

Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Minia University, Minia, Egypt.

Background: Hypertensive disorders are the most common complication in pregnancy which can even lead to maternal mortality. Hydralazine hydrochloride (HHC), a direct-acting vasodilator, is intravenously used as the first-line therapy in controlling hypertension in pregnancy (preeclampsia). It suffers poor oral bioavailability (26%-50%) due to first-pass metabolism. Read More

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November 2018
3 Reads

Preeclampsia and academic performance in children: A nationwide study from Iceland.

PLoS One 2018 21;13(11):e0207884. Epub 2018 Nov 21.

Centre of Public Health Sciences, Faculty of Medicine, University of Iceland, Reykjavik, Iceland.

Background: Hypertensive disorders complicate up to 10% of pregnancies. Evidence suggests a potential association between maternal hypertensive disorders during pregnancy, particularly preeclampsia, and adverse neurodevelopment in the offspring, but existing studies are subject to limitations. We aimed to assess whether in-utero exposure to preeclampsia/eclampsia negatively impacts academic performance at ages 9, 12 and 15 years. Read More

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November 2018
1 Read

Drug Transport at the Brain and Endothelial Dysfunction in Preeclampsia: Implications and Perspectives.

Front Physiol 2018 6;9:1502. Epub 2018 Nov 6.

Division of Pharmacy and Optometry, School of Health Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, United Kingdom.

Transport of drugs across biological barriers has been a subject of study for decades. The discovery and characterization of proteins that confer the barrier properties of endothelia and epithelia, including tight junction proteins and membrane transporters belonging to the ATP-binding cassette (ABC) and Solute Carrier (SLC) families, represented a significant step forward into understanding the mechanisms that govern drug disposition. Subsequently, numerous studies, including both pre-clinical approaches and clinical investigations, have been carried out to determine the influence of physiological and pathological states on drug disposition. Read More

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November 2018
5 Reads

Increased Neutrophil Activation and Plasma DNA Levels in Patients with Pre-Eclampsia.

Thromb Haemost 2018 Dec 19;118(12):2064-2073. Epub 2018 Nov 19.

Cyrus Tang Hematology Center, Collaborative Innovation Center of Hematology, State Key Laboratory of Radiation Medicine and Prevention, Soochow University, Suzhou, China.

Pre-eclampsia (PE) is a chronic inflammatory disease in pregnancy, which is associated with enhanced blood coagulation and high thrombotic risk. To date, the mechanisms underlying such an association are not fully understood. Previous studies reported high levels of plasma deoxyribonucleic acid (DNA) in PE women, but the cellular source of the circulation DNA remains unknown. Read More

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December 2018
2 Reads

Single-cell reconstruction of the early maternal-fetal interface in humans.

Nature 2018 Nov 14;563(7731):347-353. Epub 2018 Nov 14.

Wellcome Sanger Institute, Cambridge, UK.

During early human pregnancy the uterine mucosa transforms into the decidua, into which the fetal placenta implants and where placental trophoblast cells intermingle and communicate with maternal cells. Trophoblast-decidual interactions underlie common diseases of pregnancy, including pre-eclampsia and stillbirth. Here we profile the transcriptomes of about 70,000 single cells from first-trimester placentas with matched maternal blood and decidual cells. Read More

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November 2018
10 Reads

Severe maternal outcomes in eastern Ethiopia: Application of the adapted maternal near miss tool.

PLoS One 2018 14;13(11):e0207350. Epub 2018 Nov 14.

Department of Obstetrics and Gynecology, University Medical Centre Groningen, University of Groningen, Groningen, the Netherlands.

Background: With the reduction of maternal mortality, maternal near miss (MNM) has been used as a complementary indicator of maternal health. The objective of this study was to assess the frequency of MNM in eastern Ethiopia using an adapted sub-Saharan Africa MNM tool and compare its applicability with the original WHO MNM tool.

Methods: We applied the sub-Saharan Africa and WHO MNM criteria to 1054 women admitted with potentially life-threatening conditions (including 28 deaths) in Hiwot Fana Specialized University Hospital and Jugel Hospital between January 2016 and April 2017. Read More

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November 2018
4 Reads

Pre-eclampsia onset and SPARC: A possible involvement in placenta development.

J Cell Physiol 2018 Nov 13. Epub 2018 Nov 13.

Department of Experimental and Clinical Medicine, Università Politecnica delle Marche, Ancona, Italy.

Pre-eclampsia (PE) is a multisystem disorder commonly diagnosed in the latter half of pregnancy and it is a leading cause of intrauterine fetal growth retardation (IUGR). The aim of this study was to investigate the localization and the role of SPARC, secreted protein acidic, and rich in cysteine, in PE and PE-IUGR placentas in comparison with normal placentas. SPARC was mainly expressed in the villous and extravillous cytotrophoblastic cells in first trimester, whereas in PE, PE-IUGR and at term placentas, SPARC immunostaining was visible in both cytotrophoblastic cells and syncytiotrophoblast. Read More

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November 2018
1 Read

Recurrent Cholangiocarcinoma in Pregnancy: A Case Report.

AJP Rep 2018 Oct 12;8(4):e261-e263. Epub 2018 Nov 12.

Department of Obstetrics and Gynecology, Cooper University Health Care, Camden, New Jersey.

Hepatobiliary malignancies during pregnancy are extremely rare and portend a poor prognosis. There are only seven published cases of cholangiocarcinoma in an obstetrical patient, all are cases of primary cholangiocarcinoma (1-7). Herein, we describe the first case of recurrent cholangiocarcinoma during pregnancy. Read More

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October 2018
1 Read

Population Pharmacokinetic Modeling to Evaluate Standard Magnesium Sulfate Treatments and Alternative Dosing Regimens for Women With Preeclampsia.

J Clin Pharmacol 2018 Nov 13. Epub 2018 Nov 13.

UNDP/UNFPA/UNICEF/WHO/World Bank Special Programme of Research, Development and Research Training in Human Reproduction, Department of Reproductive Health and Research, World Health Organization, Geneva, Switzerland.

Magnesium sulfate is the standard therapy for prevention and treatment of eclampsia. Two standard dosing regimens require either continuous intravenous infusion or frequent, large-volume intramuscular injections, which may preclude patients from receiving optimal care. This project sought to identify alternative, potentially more convenient, but similarly effective dosing regimens that could be used in restrictive clinical settings. Read More

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November 2018
3 Reads

Maternal Serum Uric Acid as a Predictor of Severity of Hypertensive Disorders of Pregnancy: A Prospective Cohort Study.

Curr Hypertens Rev 2018 Nov 12. Epub 2018 Nov 12.

Department of Physiology Uttar Pradesh University of Medical Sciences Saifai, Etawah, Uttar Pradesh. India.

Objective: Assess the relationship between maternal serum uric acid and severity of Hypertensive disorders of pregnancy in a rural tertiary care centre.

Materials And Methods: Present study was conducted in Obstetrics and Gynaecology department of rural tertiary care centre of Northern India over seven months (October 2016-May 2017) on 110 women admitted with a Hypertensive disorder of pregnancy (Gestational hypertension, Pre-eclampsia, Eclampsia) at ≥34 weeks gestation. Maternal serum uric acid levels were compared in three groups in relation to disease severity, mode of delivery, maternal outcome. Read More

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November 2018
12 Reads

Analysis of Proteinuria Estimation Methods in Hypertensive Disorders of Pregnancy.

J Obstet Gynaecol India 2018 Dec 23;68(6):452-455. Epub 2017 Nov 23.

Department of Physiology, Gadag Institute of Medical Sciences (GIMS), Gadag, 587103 India.

Purpose Of The Study: The gold-standard 24-h urine collection method for protein estimation is inconvenient and is associated with a delay in laboratory analysis. This study was undertaken to compare sulphosalicylic acid test, urine dipstick test, urine protein-to-creatinine ratio with 24-h urine protein estimation in pre-eclampsia cases.

Methods: This is a comparative study and consists of a single group of 764 subjects. Read More

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December 2018
1 Read

Endogenous carbon monoxide production by menadione.

Placenta 2018 Nov 28;71:6-12. Epub 2018 Sep 28.

Department of Biomedical and Molecular Sciences, Queen's University, Kingston, Ontario, K7L 3N6, Canada; Department of Obstetrics and Gynaecology, Queen's University, Kingston, Ontario, K7L 3N6, Canada. Electronic address:

Introduction: Smokers have a significantly decreased risk of pre-eclampsia (PE), possibly attributed to an increase in blood carbon monoxide (CO) concentrations. At physiological concentrations, CO has been demonstrated to have placental vasodilatory and anti-inflammatory properties. Increasing endogenous CO production may have therapeutic potential to either prevent or treat PE. Read More

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November 2018
1 Read

The Association Between Major Dietary Patterns and Pregnancy-related Complications.

Arch Iran Med 2018 Oct 1;21(10):443-451. Epub 2018 Oct 1.

Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.

Background: Most pregnancy-related complications are associated with increased risks of adverse outcomes for mother and her infant. Although, relations between diet and pregnancy's complications indicate that there may be some benefits of nutritional factors to prevent such disorders, there are rare studies regarding the associations of dietary patterns and mentioned complications. So, the aim of the present study was to determine the relationship between dietary patterns and risk of pregnancy-related complications. Read More

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October 2018
4 Reads

Changes in calcium channel proteins according to magnesium sulfate administration in placentas from pregnancies with pre-eclampsia or fetal growth restriction.

J Investig Med 2018 Nov 9. Epub 2018 Nov 9.

Department of Obstetrics and Gynecology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

We aimed to evaluate the changes in plasma membrane Ca-ATPase (PMCA) and sarcoendoplasmic reticulum CA-ATPase (SERCA-2) according to the antepartal magnesium sulfate (MgSO) administration in the placentas from pregnancies with pre-eclampsia (PE) or fetal growth restriction (FGR). Pregnant women were classified as follows: (group 1) pregnancies without PE or FGR (n=16), (group 2) pregnancies with PE or FGR but without MgSO administration (n=14), and (group 3) pregnancies with PE or FGR and with MgSO administration (n=28). We observed the localization of PMCA and SERCA-2 in placentas and compared its expression among 3 groups. Read More

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November 2018
3 Reads

Resetting the ligand binding site of placental protein 13/galectin-13 recovers its ability to bind lactose.

Biosci Rep 2018 Nov 9. Epub 2018 Nov 9.

School of Life Science, Northeast Normal University, Changchun, 130024, China.

Placental protein-13 / galectin-13 (Gal-13) is highly expressed in placenta, where its lower expression is related to pre-eclampsia. Recently, the crystal structures of wild type Gal-13 and its variant R53H at high resolution were solved. The crystallographic and biochemical results showed that Gal-13 and R53H could not bind lactose. Read More

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November 2018
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Stillbirth among women in nine states in India: rate and risk factors in study of 886,505 women from the annual health survey.

BMJ Open 2018 Nov 8;8(11):e022583. Epub 2018 Nov 8.

National Perinatal Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.

Objectives: To assess the rate of stillbirth and associated risk factors across nine states in India.

Design: Secondary analysis of cross-sectional data from the Indian Annual Health Survey (2010-2013).

Setting: Nine states in India: Madhya Pradesh, Chhattisgarh, Rajasthan, Uttarakhand, Jharkhand, Odisha, Bihar, Assam and Uttar Pradesh. Read More

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November 2018
6 Reads