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BJOG 2022 May 20. Epub 2022 May 20.

Department of Obstetrics and Gynaecology and British Columbia Children's Hospital Research Institute, University of British Columbia, Vancouver, Canada.

Background: Calcium supplementation reduces the risk of pre-eclampsia, but questions remain about the dosage to prescribe and who would benefit most.

Objective: To evaluate the effectiveness of high- (≥1 g/d) and low-dose (<1 g/d) calcium for pre-eclampsia prevention, and according to baseline dietary calcium, pre-eclampsia risk, and co-interventions, and intervention timing.

Search Strategy: CENTRAL, PubMed, Global Index Medicus, and CINAHL from inception to Feb/2/2021, clinical trial registries, reference lists, and expert input (CRD42018111239). Read More

BJOG 2022 May 20. Epub 2022 May 20.

Centre for Fertility and Health, Norwegian Institute of Public Health, Oslo, Norway.

Objective: To investigate whether intervening miscarriages and induced abortions impact the associations between interpregnancy interval after a live birth and adverse pregnancy outcomes.

Design: Population based cohort study.

Setting: Norway PARTICIPANTS: A total of 165,617 births to 143,916 women between 2008 and 2016 MAIN OUTCOME MEASURES: We estimated adjusted relative risks for adverse pregnancy outcomes using log-binomial regression, first ignoring miscarriages and induced abortions in the interpregnancy interval estimation (conventional interpregnancy interval estimates) and subsequently accounting for intervening miscarriages or induced abortions (correct interpregnancy interval estimates). Read More

Eur J Pediatr 2022 May 21. Epub 2022 May 21.

Obstetrics and Gynaecology, Ghent University Hospital, Corneel Heymanslaan 10, 9000, Ghent, Belgium.

To objective of this study was to compare neonatal magnesemia in the first 15 days of neonatal life between three groups: a control group not exposed to MgSO, a neuroprotection group, and an eclampsia prevention group, and to explore its associations with child outcomes. A retrospective single-centre cohort study was performed in a tertiary care setting. Infants admitted at the neonatal intensive care unit born between 24 and 32 weeks' gestation, regardless of etiology of preterm birth, were included. Read More

J Dev Orig Health Dis 2022 May 20:1-13. Epub 2022 May 20.

Department of Biomedical and Molecular Sciences, Queen's University, Kingston, Ontario, Canada.

Children of women with pre-eclampsia have increased risk of cardiovascular (CV) and metabolic disease in adult life. Furthermore, the risk of pregnancy complications is higher in daughters born to women affected by pre-eclampsia than in daughters born after uncomplicated pregnancies. While aberrant inflammation contributes to the pathophysiology of pregnancy complications, including pre-eclampsia, the contribution of maternal inflammation to subsequent risk of CV and metabolic disease as well as pregnancy complications in the offspring remains unclear. Read More

Sci Rep 2022 May 19;12(1):8438. Epub 2022 May 19.

Division of Neonatology & Developmental Biology, Department of Pediatrics, and the UCLA Children's Discovery & Innovation Institute, David Geffen School of Medicine at University of California Los Angeles, 10883, Le Conte Avenue, MDCC-22-412, Los Angeles, CA, 90095-1752, USA.

The placenta is a heterogeneous organ whose development involves complex interactions of trophoblasts with decidual, vascular, and immune cells at the fetal-maternal interface. It maintains a critical balance between maternal and fetal homeostasis. Placental dysfunction can lead to adverse pregnancy outcomes including intra-uterine growth restriction, pre-eclampsia, or pre-term birth. Read More

Mol Biol Rep 2022 May 18. Epub 2022 May 18.

Department of Biochemistry and Molecular Biology, Zhejiang Key Laboratory of Pathophysiology, Medical School of Ningbo University, 315211, Ningbo, China.

Kelch-like protein 3 (KLHL3) is a substrate adaptor of Cullin3-RING ubiquitin ligase (CRL3), and KLHL3-CUL3 complex plays a vital role in the ubiquitination of specific substrates. Mutations and abnormal post-translational modifications of KLHL3-CUL3 affect substrate ubiquitination and may related to the pathogenesis of Gordon syndrome (GS), Primary Hyperparathyroidism (PHPT), Diabetes Mellitus (DM), Congenital Heart Disease (CHD), Pre-eclampsia (PE) and even cancers. Therefore, it is essential to understand the function and molecular mechanisms of KLHL3-CUL3 for the treatment of related diseases. Read More

J Extracell Vesicles 2022 May;11(5):e12217

Department of Molecular Biotechnology and Health Sciences, University of Turin, Turin, Italy.

Amniotic fluid surrounding the developing fetus is a complex biological fluid rich in metabolically active bio-factors. The presence of extracellular vesicles (EVs) in amniotic fluid has been mainly related to foetal urine. We here characterized EVs from term amniotic fluid in terms of surface marker expression using different orthogonal techniques. Read More

BMC Pregnancy Childbirth 2022 May 16;22(1):411. Epub 2022 May 16.

Kilimanjaro Christian Medical University College, P.O Box 2240, Moshi, Tanzania.

Background: Caesarean delivery (CD) is the commonest obstetric surgery and surgical intervention to save lives of the mother and/or the new-borns. Despite been accepted as safe procedure, caesarean delivery has an increased risk of adverse maternal and fetal outcomes. The rising rate of caesarean delivery has been a major public health concern worldwide and the consequences that come along with it urgently need to be assessed, especially in resource limited settings. Read More

J Obstet Gynaecol Can 2022 May;44(5):547-571.e1

Montreal, QC.

Objective: This guideline was developed by maternity care providers from obstetrics and internal medicine. It reviews the diagnosis, evaluation, and management of the hypertensive disorders of pregnancy (HDPs), the prediction and prevention of preeclampsia, and the postpartum care of women with a previous HDP.

Target Population: Pregnant women. Read More

Bratisl Lek Listy 2022 ;123(6):457

LETTER TO THE EDITOR Keywords. Read More

Obstet Gynecol 2022 May;139(5):944

J Ayub Med Coll Abbottabad 2022 Apr-Jun;34(2):269-272

Department of Medicine Ayub teaching hospital Abbottabad, Pakistan.

Background: Pregnancy poses some stress on normal homeostasis of the human body and brings changes in the body which predisposes the individual towards various pathological conditions as well.

Objective: Objective of the study was to determine the magnetic resonance imaging (MRI) changes and clinical symptoms associated with these changes among patients of eclampsia and preeclampsia managed at tertiary care unit. It was a cross-sectional study, conducted at Gynaecology and obstetrics department Pak Emirates Military Hospital (PEMH) Rawalpindi. Read More

Case Rep Womens Health 2022 Jul 10;35:e00420. Epub 2022 May 10.

Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Atrium Health, 1025 Morehead Medical Drive, Suite 500, Charlotte, NC 28204, USA.

Introduction: Pregnant women affected by coronavirus disease 2019 (COVID-19) are at increased risk of severe disease, admission to an intensive care unit, and adverse pregnancy outcomes. In contrast, children typically experience a mild form of COVID-19. Nonetheless, there is a risk of multisystem inflammatory syndrome in children (MIS-C) following a SARS-CoV-2 infection. Read More

Front Endocrinol (Lausanne) 2022 28;13:905829. Epub 2022 Apr 28.

Department of Clinical Sciences, Intervention and Technology, Karolinska Institute, Stockholm, Sweden.

Regen Eng Transl Med 2022 May 10:1-13. Epub 2022 May 10.

Center for Biomedical Engineering, School of Engineering, Brown University, Providence, RI USA.

Abstract: Most of maternal deaths are preventable, and one-quarter of maternal deaths are due to pre-eclampsia and eclampsia. Prenatal screening is essential for detecting and managing pre-eclampsia. However, pre-eclampsia screening is solely based on maternal risk factors and has low (< 5% in the USA) detection rates. Read More

Trends Mol Med 2022 May 12. Epub 2022 May 12.

Department of Biomedical and Molecular Sciences, Queen's University, Kingston, ON K7L 2V5, Canada. Electronic address:

IL-33 is a member of the IL-1 family and was first identified as an alarmin that acts at mucosal barrier sites. However, IL-33 is now understood to be a pleiotropic cytokine that acts on a variety of immune and non-immune cell types to promote type 2 T helper cell (T2) inflammation as well as to regulate and suppress homeostatic processes. Of particular interest are group 2 innate lymphoid cells (ILC2s) which are activated by IL-33 and promote many IL-33-specific effects. Read More

Pregnancy Hypertens 2022 May 10;28:168-173. Epub 2022 May 10.

Santa Casa de Misericórdia of Pará, Belém, PA, Brazil.

Objective: To evaluate the prevalence of preeclampsia among cases of COVID-19 infection during pregnancy and the association between both conditions, in a multicenter cohort of Brazilian women with respiratory symptoms.

Study Design: Ancillary analysis of the Brazilian Network of COVID-19 in Obstetrics (REBRACO) study. We performed a nested case-control analysis selecting all women with COVID-19 and compared outcomes between women with and without PE. Read More

Int J Environ Res Public Health 2022 Apr 29;19(9). Epub 2022 Apr 29.

Department of Pathology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur 56000, Malaysia.

Introduction: Cyclophilin A was reported to be increased in the serum of mothers with preeclampsia, and is implicated in its pathogenesis. This study aimed to determine the expression of cyclophilin A in the placenta of mothers with and without hypertension, and to correlate its expression with maternal complications and adverse perinatal outcomes.

Materials And Methods: This study consisted of a total of 70 cases (35 cases of mothers with hypertension, and 35 normotensive mothers as a control). Read More

Int J Environ Res Public Health 2022 Apr 23;19(9). Epub 2022 Apr 23.

Center of Postgraduate Medical Education, Second Department of Obstetrics and Gynecology, 01-813 Warsaw, Poland.

Placental abruption (PA) is a separation of the placenta from the uterine wall occurring with the fetus still present in the uterine cavity. It contributes to numerous neonatal and maternal complications, increasing morbidity and mortality. We conducted a retrospective study at a tertiary perinatal care center, which included 2210 cases of labor that took place in 2015 with a PA occurrence of 0. Read More

Cells 2022 May 5;11(9). Epub 2022 May 5.

Department of Physiology and Biophysics, School of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106-4970, USA.

Obesity has been steadily increasing over the past decade in the US and worldwide. Since 1975, the prevalence of obesity has increased by 2% per decade, unabated despite new and more stringent guidelines set by WHO, CDC, and other public health organizations. Likewise, maternal obesity has also increased worldwide over the past several years. Read More

Int J Mol Sci 2022 Apr 28;23(9). Epub 2022 Apr 28.

Department of Obstetrics and Gynecology, Virginia Commonwealth University, Richmond, VA 23298-0034, USA.

Neutrophils, which extensively infiltrate maternal systemic blood vessels in preeclampsia, express protease-activated receptor 1 (PAR-1) but only during pregnancy. Neutrophils are generally considered to be non-specific in their response, but the pregnancy-specific expression of PAR-1 could result in a gene expression profile unique to pregnancy, which could help explain why the maternal inflammatory response in preeclampsia is systemic rather than localized. We sought to determine if gene expression of pregnancy neutrophils would differ if stimulated by a protease versus bacterial lipopolysaccharide (LPS). Read More

BMC Pregnancy Childbirth 2022 May 13;22(1):407. Epub 2022 May 13.

Department of Women and Children's Health, School of Life Course Sciences, Faculty of Life Science and Medicine, Kings College London, London, UK.

Background: Iron-deficiency anemia is a known risk factor for several adverse perinatal outcomes, but data on its impact on specific maternal morbidities is less robust. Further, information on associations between anemia in early pregnancy and subsequent outcomes are understudied.

Methods: The study population was derived from the Community Level Interventions for Pre-eclampsia (CLIP) trial in Karnataka State, India (NCT01911494). Read More

F S Sci 2022 Feb 19;3(1):84-94. Epub 2021 Nov 19.

Institut National de la Santé et de la Recherche Médicale (INSERM) U1076, Aix-Marseille University, Marseille, France; Immunology Laboratory, CHU Conception Marseille, AP-HM, France. Electronic address:

Objective: To explore the regulatory role of soluble CD146 (sCD146) and its interaction with galectin-1 (Gal1) in placenta-mediated complications of pregnancy.

Design: Prospective pilot and experimental studies.

Setting: University-affiliated hospital and academic research laboratory. Read More

Hum Reprod 2022 May 13. Epub 2022 May 13.

Department of Biomedical Sciences, Humanitas University, Pieve Emanuele-Milan, Italy.

Study Question: Is there an association between the different endometrial preparation protocols for frozen embryo transfer (FET) and obstetric and perinatal outcomes?

Summary Answer: Programmed FET protocols were associated with a significantly higher risk of hypertensive disorders of pregnancy (HDP), pre-eclampsia (PE), post-partum hemorrhage (PPH) and cesarean section (CS) when compared with natural FET protocols.

What Is Known Already: An important and growing source of concern regarding the use of FET on a wide spectrum of women, is represented by its association with obstetric and perinatal complications. However, reasons behind these increased risks are still unknown and understudied. Read More

J Am Coll Cardiol 2022 May;79(19):1914-1916

The Hospital for Sick Children and Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada. Electronic address: https://twitter.com/grandi_sonia.

J Am Coll Cardiol 2022 May;79(19):1901-1913

Division of Women's Health, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.

Background: Hypertensive disorders of pregnancy (HDP), including gestational hypertension and preeclampsia, are associated with an increased risk of CVD.

Objectives: The purpose of this study was to evaluate associations between HDP and long-term CVD and identify the proportion of the association mediated by established CVD risk factors.

Methods: Parous participants without CVD in the Nurses' Health Study II (n = 60,379) were followed for incident CVD from first birth through 2017. Read More

N Engl J Med 2022 05;386(19):1817-1832

From the Department of Women and Children's Health, School of Life Course Sciences, King's College London (L.A.M., K.H.N., P.D.), the Institute of Women and Children's Health, King's Health Partners Academic Health Science Centre (L.A.M., P.D.), and the Harris Birthright Research Centre for Fetal Medicine, King's College Hospital (K.H.N.) - all in London.

Ann Med 2022 Dec;54(1):1350-1356

Department of Cancer Genetics with Cytogenetic Laboratory, Medical University of Lublin, Lublin, Poland.

MicroRNAs (miRNAs) are a class of small non-coding, single-stranded RNAs (ribonucleic acids) that play important roles in many vital processes through their impact on gene expression. One such miRNA, miR210, represents a hypoxia-induced cellular miRNA group that hold a variety of functions. This review article highlights the importance of miR-210 in the development of pre-eclampsia. Read More

Placenta 2022 Jun 2;123:32-40. Epub 2022 May 2.

Institute of Biochemistry and Molecular Medicine, University of Bern, Switzerland; Swiss National Center of Competence in Research, NCCR TransCure, University of Bern, Switzerland. Electronic address:

Introduction: In pregnancy, aldosterone is linked to maternal plasma volume expansion, improved fetal and placental growth/angiogenesis and reduced maternal blood pressure. Aldosterone levels are low in women with pre-eclampsia. Given the placental growth properties of aldosterone in pregnancy, we hypothesised that increased aldosterone improves placental function ex vivo. Read More

Cell Mol Life Sci 2022 May 10;79(6):290. Epub 2022 May 10.

Center of Reproductive Medicine, State Key Laboratory of Reproductive Medicine, Research Institute for Reproductive Health and Genetic Diseases, The Affiliated Wuxi Maternity and Child Health Care Hospital of Nanjing Medical University, Wuxi, 214002, China.

Maternal cellular and humoral immune responses to the allogeneic fetoplacental unit are a normal part of pregnancy adaptation. Overactive or dysregulated immune responses that often manifest as inflammation are considered a key element for the development of preeclampsia. Infiltration and activation of macrophages, nature killer cells, and T lymphocytes are frequently observed in the decidua and placenta associated with preeclampsia. Read More