21,034 results match your criteria Echinococcosis Hydatid Cyst


New global targets for NTDs in the WHO roadmap 2021-2030.

Authors:
Adriano Casulli

PLoS Negl Trop Dis 2021 May 13;15(5):e0009373. Epub 2021 May 13.

European Union Reference Laboratory for Parasites, Department of Infectious Diseases, Istituto Superiore di Sanità, Rome, Italy.

The second World Neglected Tropical Diseases (NTDs) Day was celebrated on 30 January 2021. To mark the occasion, the World Health Organization (WHO) launched its roadmap for NTDs for the period 2021 to 2030, which is aimed at increasing prevention and control of these too-long neglected diseases. Described here is a global overview on past achievements, current challenges, and future prospects for the WHO NTDs roadmap 2021-2030. Read More

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Twenty-six years of involvement with cystic echinococcosis: a case report.

J Med Case Rep 2021 May 12;15(1):266. Epub 2021 May 12.

Department of Parasitology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, P.O. Box 61357-15794, Ahvaz, Khuzestan, Iran.

Introduction: Spinal hydatidosis, a zoonotic disease caused by infection with Echinococcus spp. larvae, is rare, but its treatment remains a significant medical challenge. Approximately 70% of patients with spinal hydatidosis have lesions in their liver, 0-15% have lung involvement, and only 0. Read More

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Bioinformatic prediction and identification of immunogenic epitopes of the antigenic 14-3-3 protein of Echinococcus multilocularis.

Acta Trop 2021 May 9:105955. Epub 2021 May 9.

Research Center for High Altitude Medicine, Qinghai University, Xining 810001, China; Qinghai-Utah Joint Research Key Lab for High Altitude Medicine, Xining 810001, China; Basic Medicine Department, Qinghai University, Xining 810001, China. Electronic address:

Introduction: Alveolar echinococcosis is a high-risk parasitic disease caused by the larval stage of Echinococcus multilocularis. The study aimed to predict and identify the dominant Th1/Th2 and B cell epitopes of the antigen protein 14-3-3 beta:alpha from Echinococcus multilocularis.

Methods: A comparison of the four amino acid sequences of 14-3-3 beta:alpha was respectively derived from Echinococcus multilocularis, Rattus norvegicus, Canis lupus familiaris, and Homo sapiens was carried out by CLUSTALW to provide a basis for excluding similar epitopes. Read More

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Endocystectomy as a conservative surgical treatment for hepatic cystic echinococcosis: A systematic review with single-arm meta-analysis.

PLoS Negl Trop Dis 2021 May 12;15(5):e0009365. Epub 2021 May 12.

Department of General, Visceral, and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany.

Background: In patients with hepatic cystic echinococcosis (CE), treatment effectiveness, outcomes, complications, and recurrence rate are controversial. Endocystectomy is a conservative surgical approach that adequately removes cyst contents without loss of parenchyma. This conservative procedure has been modified in several ways to prevent complications and to improve surgical outcomes. Read More

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[Echinococcosis of the liver: evolution of surgical treatment].

Khirurgiia (Mosk) 2021 (5):95-103

Botkin Clinical Hospital, Moscow, Russia.

Objective: To analyze the development of surgical approaches for hepatic echinococcosis.

Material And Methods: We have analyzed diagnosis and treatment of 349 patients with liver echinococcosis; 97 patients were treated at the Botkin Clinical Hospital for the period from 2009 to 2019 and 252 patients were treated in surgical hospitals of Moscow city for the period from 2014 to 2019.

Results: General and specific postoperative complications, relapses and surgical approaches were assessed. Read More

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Feasibility and acceptability of a new integrated approach to control cystic echinococcosis in Morocco: Vaccination of sheep and anthelmintic treatment of dogs.

Prev Vet Med 2021 May 4;192:105373. Epub 2021 May 4.

Department of Vaccinology, Faculty of Medicine and Health Sciences, University of Antwerp, Belgium.

Cystic echinococcosis (CE) or hydatidosis is a common parasitic disease worldwide, especially in poor and developing countries. In Morocco, CE is a major zoonosis, despite the implementation of a national control program since 2007. Therefore, in 2016, a field trial that associates the EG95 vaccine (lambs) and anthelmintic treatment (dogs) was started in the Mid Atlas, the most endemic region in Morocco, with preliminary positive results. Read More

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Incidence and risk factors associated with the development of epilepsy in patients with intracranial alveolar echinococcosis.

Epilepsy Res 2021 Apr 27;174:106643. Epub 2021 Apr 27.

Department of Neurology, West China Hospital, Sichuan University, No. 37 Guoxue Road, Chengdu, Sichuan, 610041, People's Republic of China. Electronic address:

Parasitic infection remains a critical health problem in Ganzi Tibetan Autonomous Prefecture of China. The association of epilepsy and intracranial alveolar echinococcosis (IAE) is still largely unclear. This study primarily aimed to assess both the incidence and possible risk factors of epilepsy in patients with IAE. Read More

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Response patterns in adventitial layer of Echinococcus granulosus sensu stricto cysts from naturally infected cattle and sheep.

Vet Res 2021 May 7;52(1):66. Epub 2021 May 7.

Laboratorio de Medicina Veterinaria, Escuela de Medicina Veterinaria, Facultad de Ciencias de la Vida, Universidad Andres Bello, Santiago, Chile.

Cystic echinococcosis is a zoonotic disease caused by the metacestode of Echinococcus granulosus sensu lato. The disease is characterized by the development of cystic structures inside viscera of the intermediate host, mainly liver and lungs. These cysts are formed by three layers: germinal, laminated, and adventitial layer, the latter being the local host immune response. Read More

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Prevalence of cystic echinococcosis in slaughtered livestock in Iran: a systematic review and meta-analysis.

BMC Infect Dis 2021 May 7;21(1):429. Epub 2021 May 7.

Department of Food Science & Technology, Faculty of Agriculture, Ferdowsi University of Mashhad (FUM), Mashhad, Iran.

Background: Hydatidosis is a zoonotic disease and has a great general and economic health importance in both developed and developing countries. Therefore, this systematic and meta-analytic study was conducted to determine the prevalence of cystic echinococcosis in slaughtered livestock in Iran.

Methods: The present study was conducted as a systematic review and meta-analysis. Read More

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Pulmonary echinococcosis: A rare pseudotumour of the lung.

Rare Tumors 2021 11;13:20363613211009769. Epub 2021 Apr 11.

Institut für Pathologie, DIAKO Hospital Flensburg, Flensburg, Germany.

Cystic echinococcosis is a widely endemic helminthic disease worldwide but occurs only rarely in Central Europe. Humans are infected as 'aberrant' hosts by and develop cysts in numerous different organs. 20%-30% of the affected individuals develop hydatid disease in the lungs with associated complications including pleuritis, lung abscess and pneumothorax. Read More

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Evaluation of zoonotic platyhelminthe infections identified in slaughtered livestock in Iran, 2015-2019.

BMC Vet Res 2021 May 5;17(1):185. Epub 2021 May 5.

Department of Parasitology and Mycology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Background: Platyhelminth infections of livestock can result in considerable economic losses. This study aims to evaluate the spatial frequency of cystic echinococcosis (CE), dicrocoeliasis, and fascioliasis in livestock slaughtered in Iran during the years 2015-2019 and estimate direct costs associated with organ condemnation due to these parasites.

Methods: Abattoir data from 413 abattoirs representing all 31 Iranian provinces were collected from the Iran Veterinary Organization. Read More

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Human hydatid cyst fluid-induced therapeutic anti-cancer immune responses via NK1.1 cell activation in mice.

Cancer Immunol Immunother 2021 May 4. Epub 2021 May 4.

Laboratorio de Glicobiología e Inmunología Tumoral, Institut Pasteur de Montevideo, 11400, Montevideo, CP, Uruguay.

Echinococcus granulosus is a cestode parasite which causes cystic echinococcosis disease. Previously we observed that vaccination with E. granulosus antigens from human hydatid cyst fluid (HCF) significantly inhibits colon cancer growth. Read More

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Cystic Echinococcosis: Knowledge, Attitude, and Practices (KAP) among Surgically Operated Cases in Fars Province, Southern Iran.

J Parasitol Res 2021 8;2021:9976548. Epub 2021 Apr 8.

Department of Parasitology and Mycology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.

Introduction: Cystic echinococcosis (CE) is a neglected zoonotic disease caused by with major health and economic burden. The information on how the community members perceive the disease is crucial in order to recommend an effective preventive and control plan. The current study is aimed at finding out knowledge, attitude, and practices (KAP) of surgically operated cases of hydatid cyst in educational hospitals of Shiraz in Fars Province, southern Iran, toward the CE. Read More

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Development of Optical Biosensor Using Protein A-Conjugated Chitosan-Gold Nanoparticles for Diagnosis of Cystic Echinococcosis.

Biosensors (Basel) 2021 Apr 25;11(5). Epub 2021 Apr 25.

Infectious and Tropical Disease Research Center, Tabriz University of Medical Sciences, Tabriz 51666-14766, Iran.

Human echinococcosis is a serious parasitic diseasethat still affects millions of people in many parts of the world. Since it can offer a critical threat to people's health, it is important to discover a rapid, convenient, and economical method for detection. Herein, we propose a novel point of care assay, namely, an enhanced immuno-dot-blot assay for diagnosis of cystic echinococcosis (hydatidosis). Read More

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Screening of Benzimidazole-Based Anthelmintics and Their Enantiomers as Repurposed Drug Candidates in Cancer Therapy.

Pharmaceuticals (Basel) 2021 Apr 17;14(4). Epub 2021 Apr 17.

Department of Pharmacy, G. d'Annunzio University of Chieti-Pescara, 66100 Chieti, Italy.

Repurposing of approved non-antitumor drugs represents a promising and affordable strategy that may help to increase the repertoire of effective anticancer drugs. Benzimidazole-based anthelmintics are antiparasitic drugs commonly employed both in human and veterinary medicine. Benzimidazole compounds are being considered for drug repurposing due to antitumor activities displayed by some members of the family. Read More

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Alveolar Echinococcosis of the Parotid Gland-An Ultra Rare Location Reported from Western Europe.

Pathogens 2021 Apr 3;10(4). Epub 2021 Apr 3.

Department of Otorhinolaryngology, Head and Neck Surgery, University Medical Center Bonn, Venusberg-Campus 1, 53127 Bonn, Germany.

(1) Background: (AE) is restricted to the northern hemisphere with high endemic regions in Central Europe, North and Central Asia as well as Western China. The larval stage of causes AE with tumor-like growth. Humans are accidental hosts. Read More

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Comment on the Paper "Comment on "The Value of Hepatic Vein Stent Placement as a Bridge Therapy on Treating Hepatic Alveolar Echinococcosis Presenting with Budd-Chiari Syndrome".

Ann Surg 2021 Apr 1. Epub 2021 Apr 1.

*Organ Transplantation Center, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu 611731, Sichuan, China †Chinese Academy of Sciences Sichuan Translational Medicine Research Hospital, Chengdu 610072, Sichuan, China ‡Faculty of Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, N.T., Hong Kong SAR, China.

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Serology for the diagnosis of human hepatic cystic echinococcosis and its relation with cyst staging: A systematic review of the literature with meta-analysis.

PLoS Negl Trop Dis 2021 Apr 28;15(4):e0009370. Epub 2021 Apr 28.

Instituto de Recursos Naturales y Agrobiología de Salamanca (IRNASA-CSIC), Salamanca, Spain.

Background: The diagnosis of cystic echinococcosis (CE) is primarily based on imaging, while serology should be applied when imaging is inconclusive. CE cyst stage has been reported among the most important factors influencing the outcome of serodiagnosis. We performed a systematic review and meta-analysis of the relation between cyst stage of hepatic CE and diagnostic sensitivity of serological tests, to evaluate whether their relation is a consistent finding and provide guidance for the interpretation of results of serological tests. Read More

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[Circulation of Echinococcus granulosus in Los Antiguos, Santa Cruz].

Medicina (B Aires) 2021 ;81(2):166-172

Instituto Nacional de Microbiología, ANLIS Dr. Carlos G. Malbrán, Buenos Aires, Argentina.

Hydatidosis - caused by the parasite Echinococcus granulosus - is a zoonosis endemic to the province of Santa Cruz, associated with areas of livestock production. Once infected, man may remain asymptomatic for a prolonged period but the disease has an important impact on public health owing to the complexity and costs of its treatment. This study aimed at assessing the prevalence of environmental E. Read More

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Hydatigera taeniaeformis in urban rats (Rattus rattus) in Faisalabad, Pakistan.

Infect Genet Evol 2021 Apr 24;92:104873. Epub 2021 Apr 24.

State Key Laboratory of Veterinary Etiological Biology, National Professional Laboratory for Echinococcosis, Key Laboratory of Veterinary Parasitology of Gansu Province, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730046, Gansu Province, PR China; Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Disease, Yangzhou 225009, Jiangsu Province, PR China. Electronic address:

Hydatigera taeniaeformis formerly referred to as Taenia taeniaeformis is a cestode of cats (definitive hosts) and rodents (intermediate hosts). The prevalence of the metacestode larval stage has been reported in rodents in many parts of the world even though the genetic polymorphisms or intraspecies variation is still understudied. Here, we report a prevalence of 22. Read More

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First report of cystic echinococcosis in rhinos: A fertile infection of in a Southern white rhinoceros () of Kruger National Park, South Africa.

Int J Parasitol Parasites Wildl 2021 Apr 13;14:260-266. Epub 2021 Mar 13.

Scientific Services, South African National Parks, Private Bag X402, 1350, Skukuza, South Africa.

Despite being a parasitic disease known since ancient times, some epidemiological aspects of cystic echinococcosis (CE) remain unclear. Many studies describe its prevalence and genotyping in populations of domestic animals and livestock, but data regarding wildlife are often scarce and incomplete. The available literature suggests that CE has never been reported in African rhinos. Read More

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An unsolved problem in developing countries: hydatid cysts in children.

Pediatr Surg Int 2021 Apr 25. Epub 2021 Apr 25.

Department of Pediatric Surgery, Faculty of Medicine, Ankara Yıldırım Beyazıt University, Bilkent, 06110, Ankara, Turkey.

Purpose: Hydatid cyst (HC) is a serious health problem in developing countries. The aim is to discuss the clinical information, surgical and puncture-aspiration-injection-re-aspiration (PAIR) treatments, and results of patients with HC in a developing country.

Methods: Patients were analyzed in terms of gender, age, presenting complaint, misdiagnosed HC, cyst location, cyst number, cyst size, liver HC type according to the World Health Organization Informal Working Group Echinococcosis (WHO-IWGE) classification, pulmonary HC, hemithorax locations, treatments and interventions, duration of hospitalization, follow-up period, postoperative complications, and recurrence. Read More

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Th1/Th2/Th17 cytokine profile in hepatic cystic Echinococcosis patients with different cyst stages.

Parasite Immunol 2021 Apr 23:e12839. Epub 2021 Apr 23.

State Key Laboratory of Pathogenesis, Prevention and Management of High Incidence Diseases in Central Asia, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, China.

Aims: The study aimed to investigate possible correlation between expression level of Th1/Th2/Th17-type profile and cyst viability in the systemic and local immunity of hepatic cystic Echinococcosis (CE) patients.

Methods And Results: Expression of Th1-type interleukin (IL)-2, interferon (IFN)-γ, tumour necrosis factor (TNF)-α, Th2-type IL-4, IL-6, IL-10 and Th17-type IL-17A was examined in the serum and liver samples of hepatic CE patients with different cyst stages. Compared with healthy controls, Th1/Th2/Th17-type cytokines were significantly increased in the serum of hepatic CE patients. Read More

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Human and animal cystic echinococcosis in Tataouine governorate: hypoendemic area in a hyperendemic country, myth or reality?

Parasit Vectors 2021 Apr 21;14(1):216. Epub 2021 Apr 21.

Laboratory of Medical and Molecular Parasitology-Mycology (LP3M), LR12ES08, Faculty of Pharmacy, University of Monastir, 5000, Monastir, Tunisia.

Background: Cystic echinococcosis (CE) has a worldwide distribution and is especially prevalent in North African countries. With a mean annual surgical incidence (ASI) of CE of 12.7 per 100,000 inhabitants, Tunisia is one of the most CE endemic countries in the Mediterranean area. Read More

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[Evaluation of the Effect of Hydatid Cyst Fluid on the Apoptosis Pathway in BEAS-2B and A549 Cell Lines].

Mikrobiyol Bul 2021 Apr;55(2):248-255

Hacettepe University, School of Health Services, Medical Laboratory Programme, Ankara, Turkey.

Some of the pathogenic microorganisms have been associated with cancer due to the activation of cancer precursors in the host because of the inflammatory processes. Additionally, some other pathogens prevents the tumor formation by creating an anti-neoplastic immune response which has been reported to stop the development of cancer. Cystic echinococcosis (CE) or cyst hydatid disease (CHD) is a zoonotic infection caused by the larval form of Echinococcus granulosus sensu lato in humans. Read More

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Monosegmental ALPPS combined with ante-situm liver resection: A novel strategy for end-stage hepatic alveolar echinococcosis.

Hepatobiliary Pancreat Dis Int 2021 Apr 5. Epub 2021 Apr 5.

Organ Transplantation Center, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu 610072, China. Electronic address:

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Advances in research on echinococcoses epidemiology in China.

Acta Trop 2021 Apr 18;219:105921. Epub 2021 Apr 18.

National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention, Shanghai, China; Chinese Center for Tropical Diseases Research, Shanghai, China; WHO Collaborating Centre for Tropical Diseases, Shanghai, China; National Center for International Research on Tropical Diseases, Ministry of Science and Technology, Shanghai, China; Key Laboratory of Parasite and Vector Biology, Ministry of Health, Shanghai, China. Electronic address:

Echinococcoses are serious zoonotic diseases in China's vast, western and north-western pastoral areas that has one of the highest prevalence in the world. The two most common forms, cystic echinococcosis (CE) and alveolar echinococcosis (AE), are co-epidemic in some areas causing a grave threat to people's health and economic development. Echinococcus spp. Read More

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Improvement of the Bioavailability and Anti-Hepatic Alveolar Echinococcosis by Albendazole-Isethionate/Hypromellose Acetate Succinate (HPMC-AS) Complex.

Antimicrob Agents Chemother 2021 Apr 19. Epub 2021 Apr 19.

Department of Hepatopancreatobiliary Surgery Affiliated Hospital of Qinghai University, Qinghai, 810001, P. R. China.

Maximizing the pharmacodynamics of albendazole (ABZ), which is used to treat echinococcoses, is essential for the long-term treatment of echinococcosis patients. ABZ is a weak base whose solubility depends on the pH value of the solvent. After it has been orally administered, its solubility drops sharply from when it is in gastric juices (pH 1. Read More

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PET/CT helps to determine treatment duration in patients with resected as well as inoperable alveolar echinococcosis.

Parasitol Int 2021 Apr 16;83:102356. Epub 2021 Apr 16.

Department of Nuclear Medicine, University Hospital Zurich, University of Zurich, Switzerland.

Purpose: The aim of the study was to determine the role of F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) at the end of benzimidazole therapy in alveolar echinococcosis.

Methods: A total of 22 patients undergoing PET/CT at the end of benzimidazole therapy were retrospectively registered. Maximum standardized uptake values (SUV) were measured in remaining echinococcus manifestations and compared to normal liver tissue. Read More

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Laparoscopic or open treatment for hepatic alveolar echinococcosis: A single-institution experience.

Int J Infect Dis 2021 Apr 13. Epub 2021 Apr 13.

State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia, First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, PR China; Hepatobiliary & Hydatid Department, Digestive and Vascular Surgery Centre, First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, PR China. Electronic address:

Objective: The aim of this study was to evaluate the safety and efficacy of laparoscopy in the treatment of hepatic alveolar echinococcosis (AE).

Methods: Between January 2018 and December 2019, 213 hepatic AE patients were admitted to the authors' department. Among them, 165 patients (77. Read More

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