19,638 results match your criteria Echinococcosis
J Gastrointest Surg 2018 Sep 21. Epub 2018 Sep 21.
Department of Infectious Diseases, Hospital Universitari Vall d'Hebron, PROSICS Barcelona, P° Vall d'Hebron 119-129, 08035, Barcelona, Spain.
Background: Cystic echinococcosis (CE) is a zoonosis endemic in Spain caused by the larval stage of the cestode Echinococcus granulosus and is one of the 18 neglected tropical diseases recognized by the WHO. The aim of this study was to describe the epidemiological and clinical data of CE in a surgical referral hospital.
Methods: A retrospective descriptive study of all adults' patients diagnosed with CE and followed at Vall d'Hebron University Hospital in Barcelona, Spain, between 2000 and 2015. Read More
Microsc Res Tech 2018 Sep 20. Epub 2018 Sep 20.
Imaging Center, First Affiliated Hospital, Xinjiang Medical University, China.
Nondestructive three-dimensional (3D) micromorphological imaging technique is essential for hepatic alveolar echinococcosis (HAE) disease to determine its damage level and early diagnosis, assess relative drug therapy and optimize treatment strategies. However, the existing morphological researches of HAE mainly depend on the conventional CT, MRI, or ultrasound in hospitals, unfortunately confronting with the common limit of imaging resolution and sensitivity, especially for tiny or early HAE lesions. Now we presented a phase-retrieval-based synchrotron X-ray phase computed tomography (PR-XPCT) with striking contrast-to-noise ratio and high-density resolution to visualize the HAE nondestructive 3D structures and quantitatively segment different pathological characteristics of HAE lesions without staining process at the micrometer scale. Read More
Infection 2018 Sep 17. Epub 2018 Sep 17.
Department of Internal Medicine III, Ulm University Hospital, Albert-Einstein-Allee 23, 89081, Ulm, Germany.
Purpose: The Alveolar echinococcosis (AE) is a rare zoonosis caused by the parasite Echinococcus multilocularis. To date, nothing is known about the health-related quality of life (HRQoL) in patients with AE. The aim of the study was to evaluate the HRQoL in patients with AE in comparison of the healthy population. Read More
Int J Infect Dis 2018 Sep 12. Epub 2018 Sep 12.
Department of cardiovascular surgery, Sahloul Hospital, Ceinture Route, Sousse.
Isolated cardiac location is uncommon presentation of echinococcosis (0.5-2%) and involvement of the interventricular septum is even rarer. It may lead to various complications because of rupture and embolization. Read More
Ann Hepatobiliary Pancreat Surg 2018 Aug 31;22(3):208-215. Epub 2018 Aug 31.
Institute of Liver Transplantation and Regenerative Medicine, Medanta The Medicity, Gurgaon, India.
Backgrounds/aims: A wide range of surgical approaches has been described for hepatic hydatidosis aiming primarily at the reduction of disease recurrence and minimization of postoperative morbidity.
Methods: A database analysis of patients with liver hydatidosis who underwent different surgical procedures between March 2010 and May 2016 was performed.
Results: A total of 21 patients with cystic echinococcosis (CE) and four cases of alveolar echinococcosis (AED) were detected. Read More
Exp Ther Med 2018 Oct 1;16(4):3155-3160. Epub 2018 Aug 1.
State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia, Clinical Medicine Institute, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang 830054, P.R. China.
Alveolar echinococcosis (AE) is a prevalent epidemic in the northern hemisphere, especially in central Europe and western China. Serum diagnosis is important for patients with AE, especially during the first screening. The present study purified the recombinant Em18-GST (rEm18-GST), and detected its diagnostic performance in human alveolar echinococcosis patients of Xinjiang, China with immunoblotting (IB) and enzyme-linked immunosorbent assay (ELISA). Read More
J Hepatol 2018 Sep 8. Epub 2018 Sep 8.
Gastroenterology and Hepatology, University Hospital of Zürich, Rämistrasse 100, Zürich CH-8091, Switzerland; Swiss HBP Center, University Hospital of Zürich, Rämistrasse 100, Zürich CH-8091, Switzerland. Electronic address:
Int J Mol Sci 2018 Sep 8;19(9). Epub 2018 Sep 8.
Department of Parasitology, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, China.
Cystic echinococcosis, a parasitic zoonosis that causes significant economic losses and poses a threat to public health, is caused by larvae of the tapeworm . Infection causes infertile cysts in intermediate hosts that cannot produce protoscoleces (PSCs) or complete the life cycle. Herein, we cloned, expressed, and characterised mitochondrial fission protein 1 () and programmed cell death protein 6 () from , and explored their functions related to infertile cysts. Read More
Urol Case Rep 2018 Nov 4;21:44-46. Epub 2018 Sep 4.
Department of Urology, La Rabta Hospital, Tunis, Tunisia.
Korean J Parasitol 2018 Aug 31;56(4):391-396. Epub 2018 Aug 31.
School of Medicine, Shihezi University, Shihezi, Xinjiang Uygur Autonomous Region 832002, People's Republic of China.
Cystic echinococcosis (CE) caused by E. granulosus is a serious helminthic zoonosis in humans, livestock and wildlife. Xinjiang is one of high endemic province for CE in China. Read More
Korean J Parasitol 2018 Aug 31;56(4):385-390. Epub 2018 Aug 31.
Department of Parasitology, Faculty of Veterinary Medicine, University of Firat, 23119, Elazig, Turkey.
A retrospective study was performed to report the case occurrence of cystic echinococcosis (CE) in three hospitals of north-eastern region in Punjab Province, Pakistan. We reviewed retrospectively the clinical records of patients in 4 hospitals which were diagnosed with CE during 2012-2017. A total of 198 cases, 82 (41. Read More
J Sep Sci 2018 Sep 8. Epub 2018 Sep 8.
Dipartimento di Chimica e Tecnologie del Farmaco, "Sapienza" Università di Roma, Rome, Italy.
In this study, the retention properties of the immobilized polysaccharide-derived Chiralpak IG-3 chiral stationary phase under aqueous-organic conditions were investigated. A systematic evaluation of the retention factors of the enantiomers of the chiral sulfoxide oxfendazole, endowed with anthelmintic activity and selected as test compound, was carried out changing progressively the water content in hydro-organic eluents containing methanol, ethanol or acetonitrile. From the results obtained with acetonitrile-water mobile phases and the associated retention plots, clear U-shape retention dependencies, indicative of the interplay of both hydrophilic interaction liquid chromatography and reversed-phase modes, were highlighted. Read More
Eur J Trauma Emerg Surg 2018 Sep 6. Epub 2018 Sep 6.
Department of Radiology, Fattouma Bourguiba Hospital, Monastir, Tunisia.
Purpose: The rupture of the hydatid cyst into the bile ducts is a common and serious complication. The rupture can be latent or revealed after a complication such as acute cholangitis. The objective of this study was to discuss the clinical features, radiographic findings, and surgical treatment of this rare complication. Read More
PLoS Negl Trop Dis 2018 Sep 6;12(9):e0006741. Epub 2018 Sep 6.
Instituto de Recursos Naturales y Agrobiología de Salamanca (IRNASA-CSIC), Salamanca, Spain.
Cystic echinococcosis (CE) is one of the most widespread helminthic zoonoses and is caused by the tapeworm Echinococcus granulosus complex. CE diagnosis and monitoring primarily rely on imaging techniques, complemented by serology. This is usually approached by the detection of IgG antibodies against hydatid fluid (HF), but the use of this heterogeneous antigenic mixture results in a variable percentage of false positive and negative results, and has shown to be useless for follow-up due to the long persistence of anti-HF antibodies in cured patients. Read More
Rev Peru Med Exp Salud Publica 2018 Apr-Jun;35(2):338-343
Servicio de Clínica Pediátrica, Hospital Nacional Guillermo Almenara Irigoyen. Lima, Perú.
Echinococcosis is a parasitic infection caused by Echinococcus granulosus, which, in its cystic state, forms the socalled hydatid cyst. It presents important morbidity, with possible sequelae related to the location, and high costs due to surgical and prolonged pharmacological treatment. The liver and the lung are the most common anatomical locations, and much rarer are the kidney, spleen, brain, and heart, where the latter represents 0. Read More
Chirurgia (Bucur) 2018 Jul-Aug;113(4):486-496
Objective: The aim of this study is to verify if the experience on 4 years in using minimally invasive techniques in the treatment of CE could match regarding the indications and results with the major studies on topic.
Method: During 03.2014 - 03. Read More
Int J Parasitol Parasites Wildl 2018 Dec 13;7(3):309-316. Epub 2018 Aug 13.
Department of Veterinary Science, University of Pisa, Pisa, Italy.
The European distribution of has been reported to be expanding east and north, whereas its southern limits are deemed stable. During a study on s.l. Read More
J Orthop Case Rep 2018 Mar-Apr;8(2):104-106
Department of Orthopeadic Surgery Haydarpasa Numune Training and Research Hospital, Üsküdar, İstanbul.
Introduction: Primary hydatid cyst is rarely seen in musculoskeletal system. This paper presents a case of an intramuscular hydatid cyst in gluteal region.
Case Of Report: We present the case of a 36-year-old woman affected by pain and a mass in her right gluteal region. Read More
Int Health 2018 Aug 25. Epub 2018 Aug 25.
Centre of Tropical Medicine and Travel Medicine, Department of Infectious Diseases, Division of Internal Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
Introduction: In Sudan, echinococcosis (EC) is a chronic neglected zoonotic parasitic disease caused by Echinococcus granulosus. Studies have shown high prevalence rates in dogs (50-70%), camels (35%) and sheep, goats and cattle (10-11%). In total, 0. Read More
Rev Sci Tech 2017 Dec;36(3):817-830
Dogs play valuable roles in human society. In addition to serving as pets and companions, dogs have also been important in hunting and, in recent times, as therapy animals. In India, the number of pet dogs is estimated to be around 5 million. Read More
J Med Chem 2018 Sep 7. Epub 2018 Sep 7.
Aix-Marseille Univ, Institut de Chimie Radicalaire , Laboratoire de Pharmacochimie Radicalaire , UMR 7273 CNRS, 27 Boulevard Jean Moulin , 13385 Marseille , Cedex 05 , France.
Rhinoviruses (RVs) have been linked to exacerbations of many pulmonary diseases, thus increasing morbidity and/or mortality in subjects at risk. Unfortunately, the wide variety of RV genotypes constitutes a major hindrance for the development of Rhinovirus replication inhibitors. In the current investigation, we have developed a novel series of pyrazole derivatives that potently inhibit the Rhinovirus replication. Read More
Lancet Infect Dis 2018 Sep;18(9):946
Key Laboratory of Parasite and Vector Biology, Ministry of Health, Shanghai, China; National Center for International Research on Tropical Diseases, Shanghai, China; WHO Collaborating Center for Tropical Diseases, Shanghai, China; National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention, Shanghai 200025, China. Electronic address:
Am J Trop Med Hyg 2018 Aug 20. Epub 2018 Aug 20.
Tropical Projects, Hitchin, United Kingdom.
Although albendazole has been available for human use since 1982 and used for echinococcosis since the mid-1980s, for the most part, it is only approved for the treatment of intestinal helminth diseases as a single dose. Thus, in most countries, the only available presentation is a single 400-mg tablet or two 200-mg tablets. Albendazole is, however, a recommended treatment for several parasitic diseases for which multiple doses are required, and thus, it is often necessary to provide medication in a nonstandard manner. Read More
J Pharm Anal 2018 Aug 20;8(4):234-239. Epub 2018 Apr 20.
Centro nazionale per il controllo e la valutazione dei farmaci, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy.
Recent reports have demonstrated that the new commercially available immobilized-type chiral stationary phases (CSPs) containing amylose tris(3-chloro-5-methylphenylcarbamate) (ACMPC) as a selector exhibit not only an exceptionally high enantioselectivity in high-performance liquid chromatography (HPLC) but they are also applicable to a wide range of chiral analytes. Herein, we report the results obtained in the HPLC analysis of omeprazole and its impurities B and E on the ACMPC-based Chiralpak IG-3 CSP (CSP) under polar organic conditions. A systematic evaluation of the retention characteristics of the selected benzimidazole chiral probes was carried out by changing the composition of the mobile phase and the column temperature. Read More
Mol Biochem Parasitol 2018 Aug 18;225:7-14. Epub 2018 Aug 18.
Laboratory of Medical Zoology, Nihon University College of Bioresource Sciences, Fujisawa, Kanagawa 252-0880, Japan. Electronic address:
Alveolar echinococcosis (AE) is a zoonotic parasitosis caused by larvae of the fox tapeworm, Echinococcus multilocularis. E. multilocularis is distributed widely in the Northern hemisphere, causing serious health problems in various animals and humans. Read More
Curr Opin Infect Dis 2018 Oct;31(5):383-392
Section Clinical Tropical Medicine.
Purpose Of Review: This review draws attention to patients with cystic echinococcosis migrating from highly endemic to non-endemic countries with limited experience in cystic echinococcosis management, to ultrasound-based cyst staging, and to the WHO cyst classification as a powerful, to date underused tool to triage patients into the four currently available treatment modalities.
Recent Findings: In non- and low-prevalence countries, cystic echinococcosis is often misclassified. Differential diagnoses, such as simple cysts and other benign and malignant space-occupying lesions, have similar appearances on imaging. Read More
Indian J Gastroenterol 2018 Aug 18. Epub 2018 Aug 18.
Fortis Escorts Heart Institute, Okhla Road, New Delhi, 110 025, India.
Echinococcus multilocularis (EM) is the most virulent species of the genus Echinococcus. It causes a highly lethal helminthic disease in humans. The disease may present as hepatic mass mimicking a malignant neoplasm. Read More
Int J Surg Case Rep 2018 Aug 9;50:126-129. Epub 2018 Aug 9.
Department of Anesthesiology, Aydın Menderes University, Medical Faculty Zafer District, 09100 Efeler, Aydın, Turkey.
Introduction: Cystic echinococcosis is an endemic disease in east Turkey. Echinococcosis granulosus is reported as the most common agent of cystic echinoccocus. Hydatid cysts are generally involved in lung and liver. Read More
Int J Environ Res Public Health 2018 Aug 12;15(8). Epub 2018 Aug 12.
Institute of Geodesy and Geophysics, Chinese Academy of Sciences, Wuhan 430077, China.
The study aimed to reveal the risk factors and predict the prevalence of human cystic echinococcosis (CE) in Western China. To do this, we analyzed county-wide data relating to the prevalence of human CE in seven provinces of Western China, along with associated human, natural geographical environmental data. We then used spatial analysis and multiple regression analysis to investigate the correlation between the prevalence of human CE and associated environmental factors and to create a risk map of the disease in the seven provinces. Read More
Acta Trop 2018 Nov 9;187:190-200. Epub 2018 Aug 9.
Department of Biological statistics and Epidemiology, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran.
None of the existing drugs can effectively treat the human cystic echinococcosis. This study aimed to improve the efficacy of flubendazole (FLBZ) against the protoscoleces and cysts of Echinococcus granulosus by preparing polymeric FLBZ-loaded methoxy polyethylene glycol-polycaprolactone (mPEG-PCL) nanoparticles. The protoscoleces and microcysts were treated with FLBZ-loaded mPEG-PCL nanoparticles (FLBZ-loaded nanoparticles) and free FLBZ at the final concentrations of 1, 5, and 10 μg/mL for 27 and 14 days, respectively. Read More
PLoS Negl Trop Dis 2018 Aug 9;12(8):e0006686. Epub 2018 Aug 9.
Section Clinical Tropical Medicine, University Hospital Heidelberg, Heidelberg, Germany.
Background: Mongolia is one of the endemic countries for cystic echinococcosis (CE), a zoonotic disease caused by the larval stage of Echinococcus granulosus. The goal of this study is to describe the current clinical management of CE in Mongolia, to capture the distribution of cyst stages of patients treated, and to contrast current practice with WHO-IWGE expert consensus.
Methods: Hospital records of CE patients treated between 2008 and 2015 at the three state hospitals and fulfilling the inclusion criterion 'discharge diagnosis CE' (ICD 10 code B. Read More
Infect Dis Poverty 2018 Aug 9;7(1):77. Epub 2018 Aug 9.
The Human Pathology and Immunology Department, Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region, People's Republic of China.
Background: Cystic echinococcosis (CE) and alveolar echinococcosis (AE) are highly endemic in Xiji County of Ningxia Hui Autonomous Region (NHAR) in China where the control campaign based on dog de-worming with praziquantel has been undertaken over preceding decades. This study is to determine the current prevalence of Echinococcus granulosus and E. multilocularis in domestic dogs and monitor the echinococcosis transmission dynamics. Read More
Mol Biochem Parasitol 2018 Aug 3;225:54-66. Epub 2018 Aug 3.
IMPaM, CONICET, Facultad de Medicina, Universidad de Buenos Aires, Ciudad Autónoma de Buenos Aires, Argentina. Electronic address:
The species of the genus Echinococcus are parasitic platyhelminths that cause echinococcosis and exert a global burden on public and animal health. Here we performed codon usage bias and comparative genomic analyses using whole genome and expression data of three Echinococcus species. The study of 4,710,883 codons, two orders of magnitude more than in previous research works, showed that the codon usage in Echinococcus genes is biased towards the pyrimidines T and C ending codons, with an average effective number of codons equal to 57 revealing a low codon usage bias. Read More
Ultrasound Med Biol 2018 Aug 1. Epub 2018 Aug 1.
Department of Ultrasonography, First Affiliated Hospital, Xinjiang Medical University, Urumqi, China. Electronic address:
The mean gray-scale ratio of the infiltrating zone of a lesion to the surrounding normal liver tissue was evaluated on the basis of contrast enhancement of the infiltration and proliferation zones of a hepatic alveolar echinococcosis lesion. The results were compared with the maximum standardized uptake value (SUVmax) of [F]fluorodeoxyglucose positron emission tomography/computed tomography ([F]FDG PET-CT), and the application of contrast-enhanced ultrasound in evaluating hepatic alveolar echinococcosis activity is discussed. The 36 patients with hepatic alveolar echinococcosis recruited underwent contrast-enhanced ultrasound and [F]FDG PET-CT. Read More
Int J Parasitol 2018 Aug 2. Epub 2018 Aug 2.
Chrono-environnement, UMR UBFC/CNRS 6249 aff. INRA, University of Bourgogne Franche-Comté, 25030 Besançon, France.
In zoonotic infections, the relationships between animals and humans lead to parasitic disease with severity that ranges from mild symptoms to life-threatening conditions. In cities and their surrounding areas, this statement is truer with the overcrowding of the protagonists of the parasites' life cycle. The present study aims to investigate the distribution of a parasite, Echinococcus multilocularis, which is the causative agent of alveolar echinococcosis, using copro-sampling in historically endemic rural settlements of the eastern part of France and in newly endemic areas including urban parks and settlements surrounding Paris. Read More
Chirurg 2018 Sep;89(9):735
Klinik für Allgemein‑, Viszeral- und Gefäßchirurgie, Universitätsklinikum Jena, Am Klinikum 1, 07747, Jena, Deutschland.
J Cell Physiol 2018 Aug 2. Epub 2018 Aug 2.
Immunology Research Center, Iran University of Medical Sciences, Tehran, Iran.
Hydatid cyst, the larval stage of the tapeworm Echinococcus granulosus and a causative agent of cystic echinococcosis, possesses a vast number of antigenic peptides that are constantly presented in the host immune system during infection. Here, we sought to provide more information about the cellular/humoral components engaged in the peripheral immune reactions to the fertile-cyst-derived Echinococcus alkaline phosphatase (E.ALP) in human hosts. Read More
Turkiye Parazitol Derg 2018 Apr 18. Epub 2018 Apr 18.
Department of Urology, Kafkas University School of Medicine, Kars, Turkey.
Objective: The aim of this study was to retrospectively evaluate the serological and radiological analysis and medical and surgical treatment results of patients diagnosed with cystic echinococcosis (CE).
Methods: Records belonging to a total of 67 patients diagnosed with CE who presented to the Kars Kafkas University Faculty of Medicine Research Hospital's Surgical Outpatient unit between January 2012 and December 2015 were retrospectively evaluated.
Results: Of 67 CE cases, 53 (79. Read More
Turkiye Parazitol Derg 2018 Jun;42(2):118-121
Adnan Menderes Üniversitesi Tıp Fakültesi, Tıbbi Parazitoloji Anabilim Dalı, Aydın, Türkiye.
Objective: Echinococcus granulosus, the etiological agent of cystic echinococcosis (CE) in humans and livestock, is a widely distributed zoonotic pathogen tapeworm. The infection is transmitted to humans by the ingestion of E. granulosus eggs released in the feces of definitive hosts such as dogs. Read More
Internist (Berl) 2018 Aug 1. Epub 2018 Aug 1.
Abteilung I (Innere Medizin), Bundeswehrkrankenhaus Berlin, Scharnhorststr. 13, 10115, Berlin, Deutschland.
A 19-year-old woman presented with liver capsule pain and a liver lesion on sonography, which contained microvesicular cystic, necrotic and solid fibrotic formations typical for alveolar echinococcosis (AE). The diagnosis was confirmed by serology and histopathology. This parasitic infection which is endemic in Germany is feared because of its malignant growth. Read More
Iran J Parasitol 2018 Apr-Jun;13(2):310-316
Pediatric Infectious Diseases Research Center, Mazandaran University of Medical Sciences, Sari, Iran.
Background: Human hydatid disease imposes significant impacts on public health by producing substantial morbidity and mortality in involved communities. This study aimed to evaluate the epidemiology and clinical features of hydatid cyst in northern Iran as a breeding center for the infection.
Methods: In this cross-sectional study, the hospital records of all hydatidosis-affected patients admitted in three teaching hospitals of Mazandaran Province between Mar 2005-2015 were reviewed. Read More
Parasitology 2018 Aug 2:1-13. Epub 2018 Aug 2.
Laboratoire de Parasitologie,École Nationale de Médecine Vétérinaire, Univ. Manouba,2020 Sidi Thabet,Tunisia.
Parasites reside inside or outside their hosts and get host nutrition and blood. Here, we have emphasized economic losses in cattle caused by parasitic diseases due to ecto- and endo- parasites (flies, ticks, mites and helminths). We have outlined different methods/models including economic evaluation techniques and dynamic analysis as a major class, used for the calculation of economic losses caused by parasites in cattle. Read More
Gut 2018 Jul 25. Epub 2018 Jul 25.
Department of Hepatobiliary and Pancreatic Surgery, the First Affiliated Hospital, School of Medicine, Zhejiang University; Key Laboratory of Combined Multi-organ Transplantation, Ministry of Public Health, Hangzhou, China.
Objective: To characterise gut microbiome in patients with hepatocellular carcinoma (HCC) and evaluate the potential of microbiome as non-invasive biomarkers for HCC.
Design: We collected 486 faecal samples from East China, Central China and Northwest China prospectively and finally 419 samples completed Miseq sequencing. We characterised gut microbiome, identified microbial markers and constructed HCC classifier in 75 early HCC, 40 cirrhosis and 75 healthy controls. Read More
BMC Vet Res 2018 Jul 25;14(1):224. Epub 2018 Jul 25.
Infectious and Tropical Diseases Research Center, Health Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Background: Echinococcosis and toxocarosis caused by the genus of Echinococcus and Toxocara spp. are among important helminthic diseases worldwide. Limited data on the prevalence of these parasites persuaded us to determine the prevalence of E. Read More
Acta Trop 2018 Nov 21;187:5-12. Epub 2018 Jul 21.
Laboratorio de Zoonosis Parasitarias, Instituto de Investigaciones en Producción, Sanidad y Ambiente (IIPROSAM), Facultad de Ciencias Exactas y Naturales, Universidad Nacional de Mar del Plata, Funes 3250, 7600, Mar del Plata, Argentina; Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Argentina. Electronic address:
Echinococcus granulosus causes hydatidosis or cystic echinococcosis in humans and livestock. In humans, this disease can be managed with surgery, percutaneous treatment, chemotherapy and/or observation. The chemotherapeutic agents used and approved for treatment of hydatidosis are benzimidazoles. Read More
Am J Trop Med Hyg 2018 Jul 23. Epub 2018 Jul 23.
Unit of Infectious and Tropical Diseases, IRCCS San Matteo Hospital Foundation, Pavia, Italy.
Albendazole (ABZ) is the best drug available to treat cystic echinococcosis (CE), a neglected tropical disease. Cystic echinococcosis patients often receive a continuous course of the drug for 6-12 months. In Italy, ABZ shortages occur almost on a yearly basis. Read More
Infect Immun 2018 Oct 21;86(10). Epub 2018 Sep 21.
Institute of Parasitology, Department of Infectious Diseases and Pathobiology, Vetsuisse Faculty, University of Bern, Bern, Switzerland
Alveolar echinococcosis (AE) is a lethal disease caused by infection with the metacestode stage of the helminth , which develops into a tumorlike mass in susceptible intermediate hosts. The growth potential of this parasite stage is directly linked to the nature of the surrounding periparasitic immune-mediated processes. In a first step (experiment 1), mice were orally infected with eggs, to be used for assessing the hepatic expression profiles of 15 selected cytokine and chemokine genes related to acquired immunity from 21 to 120 days postinfection. Read More
J Infect Public Health 2018 Jul 19. Epub 2018 Jul 19.
Department of Parasitology and Mycology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran. Electronic address:
Background And Objective: Cystic echinococcosis (CE) is a widespread parasitic disease caused by infection with the larval stage of a tapeworm, Echinococcus granulosus. The immune response to hydatid cyst in intermediate hosts is a complex and contradictory issue. It is suggested that a Th2 response would favor the establishment of the parasite, whereas a Th1 response would be lethal for the parasite. Read More
J Int Med Res 2018 Sep 23;46(9):3563-3569. Epub 2018 Jul 23.
1 Department of Anesthesiology, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, Chengdu 610072, Sichuan, P.R. China.
Objectives Hepatic echinococcosis (HE) is a severe parasitic disease that occurs worldwide, and radical surgery is the recommended therapy. This study was performed to investigate the efficacy of using a transversus abdominis plane (TAP) block during surgery on postoperative pain and recovery of patients with HE under the guidelines of an enhanced recovery after surgery (ERAS) protocol. Methods Fifty-eight patients from the Tibetan plateau who underwent surgery for treatment of HE by the same surgeons under the guidance of ERAS were included in the present study. Read More
J Hepatol 2018 Jul 19. Epub 2018 Jul 19.
State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia, Xinjiang Medical University, Urumqi, China; Centre of Digestive and Vascular Surgery, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, China. Electronic address:
Background & Aims: Radical resection is the best treatment for advanced hepatic alveolar echinococcosis (AE) patients. Liver transplantation is considered for selected advanced cases; however, shortage of organ donor and risk for post-operative recurrence remain challenging. The present prospective study assessed 69 end-stage patients treated by ex vivo liver resection and autotransplantation. Read More