20,554 results match your criteria Echinococcosis


Transcriptomic Features of Echinococcus granulosus Protoscolex during the Encystation Process.

Korean J Parasitol 2020 Jun 26;58(3):287-299. Epub 2020 Jun 26.

Department of Pathogenic Biology, Chongqing Medical University, Chongqing 400016, China.

Cystic echinococcosis (CE) is a zoonotic infection caused by Echinococcus granulosus larvae. It seriously affects the development of animal husbandry and endangers human health. Due to a poor understanding of the cystic fluid formation pathway, there is currently a lack of innovative methods for the prevention and treatment of CE. Read More

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http://dx.doi.org/10.3347/kjp.2020.58.3.287DOI Listing

Prevalence and risk factors associated with human cystic echinococcosis in rural areas, Mongolia.

PLoS One 2020 2;15(7):e0235399. Epub 2020 Jul 2.

Department of Biology, Mongolian National University of Medical Sciences, Ulaanbaatar, Mongolia.

Cystic echinococcosis is a chronic, complex and neglected zoonotic disease with considerable socio-economic impact on the affected population. Even though Mongolia is included in the list of high cystic echinococcosis risk countries, there has been very limited research and evidence on the prevalence or prevention of cystic echinococcosis. This field-based cross-sectional study to investigate the prevalence of cystic echinococcosis and its potential risk factors in Mongolia was conducted from April 2016 to March 2018. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0235399PLOS

Cysts and parasites in an abattoir in Northwest Ethiopia; an urgent call for action on "one health".

J Infect Dev Ctries 2020 Jun 29;14(6.1):53S-57S. Epub 2020 Jun 29.

Department of Internal Medicine, University of Gondar, Gondar, Ethiopia.

Introduction: Zoonotic parasitic infections such as echinococcosis affect cattle, sheep and goats by lowering quality of meat and hides as well as decreasing milk production. The burden of such diseases among humans is usually underestimated as they are difficult to diagnose. We used abattoir data to estimate the prevalence of zoonotic parasitic infections in animals. Read More

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http://dx.doi.org/10.3855/jidc.11713DOI Listing

Identification of hydatidosis-related modules and key regulatory genes.

PeerJ 2020 18;8:e9280. Epub 2020 Jun 18.

College of Veterinary Medicine, Northeast Agricultural University, Harbin, Heilongjiang, China.

Background: caused by larval of is prevalent all over the world. Although clinical experience showed that the presence of tapeworms could not be found in liver lesions, the repeated infection and aggravation of lesions still occur in the host. Here, this study constructed a multifactor-driven disease-related dysfunction network to explore the potential molecular pathogenesis mechanism in different hosts after infection. Read More

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http://dx.doi.org/10.7717/peerj.9280DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7306218PMC

Analyzing Signal Peptides for Secretory Production of Recombinant Diagnostic Antigen B8/1 from : An Approach.

Mol Biol Res Commun 2020 Apr;9(1):1-10

Department of Biochemistry, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.

Recombinant AgB8/1 as the most evaluated antigen for serological diagnosis of Cystic Echinococcosis (CE) can provide early and accurate diagnosis for proper management and treatment of the disease. Thus, the secretory production of this recombinant protein is the main goal and the application of signal peptides at the N terminus of the desired protein can help to achieve this goal. The present study applied few bioinformatics tools to evaluate several signal peptides to offer the best candidate for extracellular production of AgB8/1 of in . Read More

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http://dx.doi.org/10.22099/mbrc.2019.35429.1457DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7275822PMC

Human cystic echinococcosis in southwest Iran: a 15-year retrospective epidemiological study of hospitalized cases.

Trop Med Health 2020 19;48:49. Epub 2020 Jun 19.

Department of Parasitology and Mycology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.

Background: Cystic echinococcosis (CE) is considered as a neglected disease with significant mortality and morbidity in most of the developing countries. The current study aimed to retrospectively assess the demographic and epidemiologic features of human CE surgical cases in a 15-year period in Fars province, southwestern Iran.

Methods: A 15-year (2004-2018) retrospective study was conducted to find out the epidemiological and clinical picture of CE in patients who undergone surgeries for CE in two main hospitals in Fars Province, southwestern Iran. Read More

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http://dx.doi.org/10.1186/s41182-020-00238-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7304208PMC

Current status of ex-vivo liver resection and autologous liver transplantation for end-stage hepatic alveolar echinococcosis.

Ann Palliat Med 2020 Jun 12. Epub 2020 Jun 12.

Clinical Immunology Translational Medicine Key Laboratory of Sichuan Province & Organ Transplantation Center, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.

Hepatic alveolar echinococcosis (HAE) is a cosmopolitan zoonosis distribute widely in the northern hemisphere with high estimated 10-year mortality. Radical resection combined with oral albendazole administration are the major methods for HAE treatment, whereas most patients delayed diagnosis and treatment because which was considered as benign disease. For the cases with end-stage HAE could not be treated through conventional hepatectomy, allograft liver transplantation (LT) was regarded as a life-saving technique previously. Read More

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http://dx.doi.org/10.21037/apm-20-184DOI Listing

Comment on Retrospective Study of Cystic Echinococcosis in a Recent Cohort of a Referral Center for Liver Surgery.

J Gastrointest Surg 2020 Jun 22. Epub 2020 Jun 22.

Department of Surgery and Liver Transplant Institute, Inonu University Faculty of Medicine, Elazig Yolu 10. Km, 44280, Malatya, Turkey.

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http://dx.doi.org/10.1007/s11605-020-04690-8DOI Listing

Source attribution of human echinococcosis: A systematic review and meta-analysis.

PLoS Negl Trop Dis 2020 Jun 22;14(6):e0008382. Epub 2020 Jun 22.

Department of Biomedical Science, Institute of Tropical Medicine, Belgium.

Background: A substantial proportion of echinococcosis transmission to humans via contamination of food has been assumed. However, the relative importance of food as a transmission vehicle has previously been estimated through expert opinion rather than empirical data.

Objective: To find and evaluate empirical data that could be used to estimate the source attribution of echinococcosis, in particular the proportion that is transmitted through contaminated food. Read More

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http://dx.doi.org/10.1371/journal.pntd.0008382DOI Listing

Transmission ways of Echinococcus granulosus in rare muscular locations of hydatid disease.

Ann Med Surg (Lond) 2020 Jul 22;55:332-333. Epub 2020 May 22.

Department of General Surgery and Medico, Surgical Specialties, University of Catania, Policlinico Vittorio Emanuele Hospital, Via S. Sofia 78, 95123, Catania, Italy.

The most common modality of transmission of the Echinococcus granulosus is through the alimentary tract. Other ways of infestation are questionable. Airborne penetration of bronchial venules to reach the heart and the systemic circulation has been advocated, but never demonstrated. Read More

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http://dx.doi.org/10.1016/j.amsu.2020.04.047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7296182PMC

Contribution of NIPD-CTDR to the parasitic diseases control and elimination in China: Memory of the 70th anniversary for NIPD-CTDR.

Adv Parasitol 2020 6;110:401-427. Epub 2020 May 6.

National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention; Chinese Center for Tropical Diseases Research; Key Laboratory of Parasite and Vector Biology, Ministry of Health; National Center for International Research on Tropical Diseases, Ministry of Science and Technology; WHO Collaborating Centre for Tropical Diseases, Shanghai, People's Republic of China. Electronic address:

China has achieved a great success in control and elimination of key parasitic diseases. In 2007, the elimination of lymphatic filariasis was verified by WHO. The schistosomiasis incidence and snail-distributed areas have reduced to the lowest level in the history. Read More

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http://dx.doi.org/10.1016/bs.apar.2020.02.003DOI Listing
May 2020
6.226 Impact Factor

Contribution to the echinococcosis control programme in China by NIPD-CTDR.

Adv Parasitol 2020 3;110:107-144. Epub 2020 Jun 3.

National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention, Shanghai, People's Republic of China; Chinese Center for Tropical Diseases Research, Shanghai, People's Republic of China; WHO Collaborating Centre for Tropical Diseases, Shanghai, People's Republic of China; National Center for International Research on Tropical Diseases, Ministry of Science and Technology, Shanghai, People's Republic of China; Key Laboratory of Parasite and Vector Biology, Ministry of Health, Shanghai, People's Republic of China. Electronic address:

As a zoonotic parasitosis caused by the parasitism of Echinococcus larvae, echinococcosis imposes serious disease and economic burdens on human beings and society, and is thus a global public health issue. Its complex life history, wide distribution, the combined influence of various epidemic factors, coupled with the unique natural environment, customs, and religious beliefs in endemic areas, pose a huge challenge to the national echinococcosis control programme in China. Accurate early detection and confirmation of diagnosis of echinococcosis, the use of effective drugs, real-time surveillance of the infection status of populations and various hosts, controlling the source of infection, and blocking the route of transmission are of enormous significance for control. Read More

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http://dx.doi.org/10.1016/bs.apar.2020.04.010DOI Listing
June 2020
6.226 Impact Factor

Diagnostic performance of protoscolices antigens in the serodiagnosis of human cystic echinococcosis.

J Immunoassay Immunochem 2020 Jun 18:1-8. Epub 2020 Jun 18.

Department of Parasitology and Mycology, School of Medicine, Shiraz University of Medical Sciences , Shiraz, Iran.

The development of suitable serological tests for the diagnosis of CE is still necessary. This study aimed to evaluate the efficacy of ELISA in the diagnosis of human cystic echinococcosis (CE), using parasite protoscolices antigens. Liver hydatid cysts were isolated from sheep infected with hydatid cysts and the protoscolices were isolated from the hydatid cyst fluid. Read More

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http://dx.doi.org/10.1080/15321819.2020.1781653DOI Listing

Successful robotic radical resection of hepatic echinococcosis located in posterosuperior liver segments.

World J Gastroenterol 2020 Jun;26(21):2831-2838

The Second Department of Hepatopancreatobiliary Surgery, The First Medical Center, Chinese People's Liberation Army General Hospital, Beijing 100853, China.

Background: Radical resection is an important treatment method for hepatic echinococcosis. The posterosuperior segments of the liver remain the most challenging region for laparoscopic or robotic hepatectomy.

Aim: To demonstrate the safety and preliminary experience of robotic radical resection of cystic and alveolar echinococcosis in posterosuperior liver segments. Read More

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http://dx.doi.org/10.3748/wjg.v26.i21.2831DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7284188PMC

Primary Thoracic Wall Hydatid Cyst Extended to the Abdominal wall: A Case Report.

Iran J Med Sci 2020 May;45(3):220-223

Department of Health Care, School of Medicine, Iranshahr University of Medical Sciences, Iranshahr, Iran.

Hydatid disease (HD) is an infectious disease caused by echinococcosis. Hydatid cyst (HC) most commonly invades the liver (60-70%) and the lungs (20-25%). However, other parts of the body and even unusual locations can be infected, mimicking a benign lesion that could be easily missed. Read More

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http://dx.doi.org/10.30476/ijms.2019.82036.DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253488PMC

Cholecysto-Hydatid Cyst Fistula: A Rare Cause of Cholangitis.

Am J Case Rep 2020 Jun 17;21:e921914. Epub 2020 Jun 17.

Department of General Surgery, Faculty of Medicine, Afyonkarahisar Health Sciences University, Afyonkarahisar, Turkey.

BACKGROUND Cholecysto-hydatid fistula is a rare complication of liver echinococcosis; suppurative cholangitis due to cholecysto-hydatid fistula is even rarer. A multidisciplinary approach is required by radiology and surgery departments during the preoperative diagnosis and treatment processes of these cases. In this paper, a patient treated with suppurative cholangitis due to cholecysto-hydatid fistula is presented. Read More

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http://dx.doi.org/10.12659/AJCR.921914DOI Listing

Prediction and Identification of Epitopes in the Emy162 Antigen of Echinococcus multilocularis.

Acta Parasitol 2020 Jun 15. Epub 2020 Jun 15.

Department of Hepatopancreatobiliary Surgery, Affiliated Hospital of Qinghai University, No. 29 Tongren Road, Xining, 810001, China.

Introduction: Alveolar echinococcosis (AE) is a zoonotic disease caused by the parasitism of Echinococcus multilocularis larvae in the intermediate host or the final host. This study aims to identify and analyze the B-cell and T-cell (Th1, Th2 and Th17) epitopes of E. multilocularis antigen Emy162. Read More

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http://dx.doi.org/10.2478/s11686-020-00231-0DOI Listing

Metformin suppresses development of the larval stage targeting the TOR pathway.

Antimicrob Agents Chemother 2020 Jun 15. Epub 2020 Jun 15.

Laboratorio de Zoonosis Parasitarias, Departamento de Biología, Facultad de Ciencias Exactas y Naturales, Universidad Nacional de Mar del Plata (UNMdP), Funes 3350, Nivel Cero, (7600) Mar del Plata, Argentina

Alveolar echinococcosis (AE) is a severe disease caused by the larval stage of the tapeworm Current chemotherapeutic treatment options based on benzimidazoles are of limited effectiveness, which underlines the need to find new anti-echinococcosis drugs. Metformin is an anti-hyperglycemic and anti-proliferative agent that shows activity against the related parasite Hence, we assessed the and effects of the drug on Meformin exerted significant dose-dependent killing effects on cultured parasite stem cells and protoscoleces and significantly reduced the de-differentiation of protoscoleces into metacestodes. Likewise, oral administration of metformin (50 mg/kg/day for 8 weeks) was effective in achieving a significant reduction of parasite weight in a secondary murine AE model. Read More

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http://dx.doi.org/10.1128/AAC.01808-19DOI Listing

The correlations between Th1 and Th2 cytokines in human alveolar echinococcosis.

BMC Infect Dis 2020 Jun 15;20(1):414. Epub 2020 Jun 15.

Qinghai Institute for Endemic Disease Prevention and Control, Xining, 811602, Qinghai Province, China.

Background: Alveolar echinococcosis (AE) is a zoonotic parasitic disease caused by Echinococcus multilocularis larval tapeworm infections in humans that severely impairs the health of affected patients in the northern hemisphere.

Methods: The expression levels of 20 cytokines associated with AE infection were measured by enzyme-linked immunosorbent assay, and the correlations between these cytokines were analysed in the R programming language.

Results: Serum cytokine levels differed among individuals in both the AE patient and healthy control groups. Read More

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http://dx.doi.org/10.1186/s12879-020-05135-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7294603PMC

The immunotherapy with hMASP-2 DNA nanolipoplexes against echinococcosis in experimentally protoscolex-infected mice.

Acta Trop 2020 Jun 12;210:105579. Epub 2020 Jun 12.

Department of Immunology, School of Basic Medical Sciences, Lanzhou University, Lanzhou, 730000, China; Key Lab of Preclinical Study for New Drugs of Gansu Province, Lanzhou, 730000, China. Electronic address:

Cystic echinococcosis (CE), a complex and neglected zoonotic infectious disease, is mainly caused by larval tapeworm Echinococcus granulosus with a worldwide distribution. For CE, an effective drug treatment is not yet available. The present study was conducted to evaluate the efficacy of hMASP-2-based immunotherapy against hydatid cysts by using murine model. Read More

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http://dx.doi.org/10.1016/j.actatropica.2020.105579DOI Listing

Renal echinococcosis; the parasite, host immune response, diagnosis and management.

J Infect Dev Ctries 2020 May 31;14(5):420-427. Epub 2020 May 31.

Department of Medical Parasitology and Mycology, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran.

Renal echinococcosis is a rare parasite-caused disease of humans and animals; it makes up about 4% of confirmed cases of cystic echinococcosis. It is a zoonotic disease that occurs in the intermediate hosts harboring the larval stage, the hydatid cyst, of Echinococcus spp. The renal involvement is often asymptomatic or with unspecific signs. Read More

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http://dx.doi.org/10.3855/jidc.11496DOI Listing

The Molecular Epidemiology of Infections.

Pathogens 2020 Jun 8;9(6). Epub 2020 Jun 8.

School of Veterinary and Life Sciences, Murdoch University, Murdoch, WA 6150, Australia.

Molecular epidemiology (ME) is the application of molecular tools to determine the causation of disease. With infectious diseases, such as echinococcosis, this applies to identifying and characterising the aetiological agents and elucidating host range. Such an approach has been very successful with the causative agents of echinococcosis, species of , initially by providing a workable and practical taxonomy and subsequently determining transmission patterns in endemic areas. Read More

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http://dx.doi.org/10.3390/pathogens9060453DOI Listing

A Pilot Comparative Study Between Serological and Genetic Investigations in Relationship to Clinical Outcomes on Patients with Cystic Echinococcosis.

Helminthologia 2020 Jun 23;57(2):91-99. Epub 2020 May 23.

Ege University, Faculty of Medicine, Department of Parasitology, 35100 Izmir, Turkey.

The aim of this study was to investigate whether Enzyme-Linked Immunosorbent Assays (ELISA) and Western Blotting (WB) methods could contribute to the assessment of clinical outcomes in genotype-defined cystic echinococcosis (CE) patients. Twenty-nine human isolates and blood samples have been taken from patients who underwent surgery or percutaneous aspiration (PAIR) for therapeutic purposes at Ege University and Manisa Celal Bayar University Hospitals. All sera of patients were screened for the presence of IgG antibodies using in-house approved ELISA and WB methods. Read More

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http://dx.doi.org/10.2478/helm-2020-0012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7261030PMC

Microsatellite Investigations of Multiple Sensu Stricto Cysts in Single Hosts Reveal Different Patterns of Infection Events between Livestock and Humans.

Pathogens 2020 Jun 5;9(6). Epub 2020 Jun 5.

Anses LRFSN, Wildlife Surveillance and Eco-Epidemiology Unit, National Reference Laboratory for Echinococcus spp.,54220 Malzéville, France.

Cystic echinococcosis (CE) caused by the cestode sensu lato (s.l.) is a worldwide zoonosis and sensu stricto (s. Read More

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http://dx.doi.org/10.3390/pathogens9060444DOI Listing

Screening of Cystic Echinococcosis and Toxocariasis in Urmia Municipal Workers, Northwest Iran.

Infect Disord Drug Targets 2020 Jun 9. Epub 2020 Jun 9.

Cellular and Molecular Research Center & Department of Medical Parasitology and Mycology, Urmia University of Medical Sciences, Urmia. Iran.

Background: Echinococcus granulosus and Toxocara spp. the causative agents of hydatid cyst and toxocariasis in human and animals, are zoonotic infection with medical and veterinary significance respectively.

Aim: Herein, we aimed to investigate the seroprevalence of toxocariasis and cystic echinococcosis in Urmia municipal workers (gardeners and sweepers) in 2018 using ELISA assay. Read More

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http://dx.doi.org/10.2174/1871526520666200609121400DOI Listing

[An Update on the Epidemiological Situation of Alveolar Echinococcosis: Recording and Reporting Structures in Austria, Switzerland and Germany].

Gesundheitswesen 2020 Jun 8. Epub 2020 Jun 8.

Klinische Abteilung für Infektionen und Tropenmedizin, Medizinische Universität Wien Universitätsklinik für Innere Medizin I, Wien, Austria.

Objective:  Alveolar echinococcosis (AE) is a rare disease in Austria, Switzerland and Germany (DACh) caused by an infection with the parasite Echinococcus multilocularis. The aim of the study was to describe differences in the detection and reporting systems of alveolar echinococcosis in Austria, Switzerland and Germany and to describe epidemiological trends.

Methodology:  As part of an epidemiological update on 6 September 2019 in Ulm, Germany, experts and representatives discussed differences in the reporting and recording systems as well as the current epidemiological situation. Read More

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http://dx.doi.org/10.1055/a-1138-0692DOI Listing

Autochthonous liver cystic hydatid: Past or actual French shepherd's disease?

IDCases 2020 26;21:e00843. Epub 2020 May 26.

IHU-Méditerranée Infection, Marseille, France.

Autochthonous hydatidosis in France and western Europa are uncommon since the beginning of the 21st century. We report here an authentic indigenous cystic echinococcosis case in a French shepherd. The risk of remerging pathology should not be neglected and measures to interrupt parasite transmission are still relevant. Read More

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http://dx.doi.org/10.1016/j.idcr.2020.e00843DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7264046PMC

Retraction Note to: Antigen based detection of cystic echinococcosis in buffaloes using ELISA and Dot-EIA.

J Parasit Dis 2020 06 29;44(2):496. Epub 2020 Apr 29.

Department of Veterinary Parasitology, Madras Veterinary College, Tamilnadu Veterinary and Animal Sciences University, Chennai, 600 007 India.

[This retracts the article DOI: 10.1007/s12639-016-0762-9.]. Read More

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http://dx.doi.org/10.1007/s12639-020-01225-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7244688PMC

A case of hepatic hydatid cyst together with pyogenic liver abscess in a Nepali patient.

J Parasit Dis 2020 Jun 18;44(2):472-475. Epub 2020 Mar 18.

Área de Parasitología, Departamento de Agroquímica y Medio Ambiente, Universidad Miguel Hernández de Elche, Campus de Sant Joan, 03550 Sant Joan, Alicante Spain.

Hydatidic disease (echinococcosis) is a significant health problem in Nepal. In humans, mainly involves liver and commonly remains silent without symptoms or causing only mild pressure symptomatology. However, inadequate invasive medical procedures may cause the rupture of the cyst with serious complications, anaphylactic shock and death. Read More

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http://dx.doi.org/10.1007/s12639-020-01213-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7244686PMC

Antiparasitic effects of essential oil nano-emulsion on larval stages of .

J Parasit Dis 2020 Jun 13;44(2):429-435. Epub 2020 Jan 13.

Department of Parasitology and Mycology, School of Medicine, Zanjan University of Medical Sciences (ZUMS), Mahdavi Blvd., Shahrak Karmandan, P.O. Box 45139-56111, Zanjan, Iran.

Various protoscolicidal agents are indicated for the prevention of recurrence of cystic echinococcosis caused by the larval stage of ; however, most of these chemicals have adverse side effects. This study evaluated the effects of essential oil (ZEO) nano-emulsion and emulsion at the concentrations of 1, 2, 5, 10, 15, and 20 µl/ml on protoscoleces. Albendazole (5 mg/ml), normal saline, and nano-emulsion without ZEO served as control groups. Read More

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http://dx.doi.org/10.1007/s12639-020-01193-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7244658PMC

A young woman from an Echinococcus-endemic area with progressive abdominal distension: a case report.

J Med Case Rep 2020 Jun 8;14(1):65. Epub 2020 Jun 8.

Divison of Hepatology, Clinic of Gastroenterology, Hepatology, Infectious Diseases and Pneumology, University Hospital Leipzig, Liebigstraße 20, 04103, Leipzig, Germany.

Background: Cystic echinococcosis is a zoonotic infection caused by Echinococcus granulosus. This case report shows the difficulty in differential diagnosis in a patient with highly suspected hydatid disease.

Case Presentation: A 29-year-old Chinese woman presented with progressive abdominal distension. Read More

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http://dx.doi.org/10.1186/s13256-020-02388-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7278052PMC

Portal hypertension as a result of the incomplete surgically treated advanced alveolar echinococcosis: a case description.

BMC Gastroenterol 2020 Jun 5;20(1):176. Epub 2020 Jun 5.

Department and Clinic of Tropical and Parasitic Diseases, Poznan University of Medical Sciences, Przybyszewskiego Street 49, 60-355, Poznań, Poland.

Background: Infection of Echinococcus multilocularis causes in humans the alveolar echinococcosis. Although the infection has world-wide distribution it is rarely detected. Diagnosis of alveococcosis is difficult because of not typical clinical picture and irregular results of radiological examinations suggesting neoplasmatic process which begins in the liver tissue or in the biliary tracts. Read More

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http://dx.doi.org/10.1186/s12876-020-01320-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7275433PMC

International consensus on terminology to be used in the field of echinococcoses.

Parasite 2020 3;27:41. Epub 2020 Jun 3.

Past-President of the World Association of Echinococcosis, President of the College of General Surgery of the Portuguese Medical Association, PT-1649-028 Lisbon, Portugal.

Echinococcoses require the involvement of specialists from nearly all disciplines; standardization of the terminology used in the field is thus crucial. To harmonize echinococcosis terminology on sound scientific and linguistic grounds, the World Association of Echinococcosis launched a Formal Consensus process. Under the coordination of a Steering and Writing Group (SWG), a Consultation and Rating Group (CRG) had the main missions of (1) providing input on the list of terms drafted by the SWG, taking into account the available literature and the participants' experience; and (2) providing independent rating on all debated terms submitted to vote. Read More

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http://dx.doi.org/10.1051/parasite/2020024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7273836PMC

Suspected Regional Lymph Node Metastasis in Hepatic Alveolar Echinococcosis: A Case Report.

Iran J Parasitol 2020 Jan-Mar;15(1):138-141

Department of Hepatobiliary and Pancreatic Surgery, Affiliated Hospital of Qinghai University, Xining, Qinghai 810001, P.R.China.

There is no direct evidence to support the existence of regional lymph node metastatic routes in hepatic alveolar echinococcosis, and only a few literature have been reported. There was a case of hepatic alveolar echinococcosis suspected of metastasis of regional lymph node in Clinical Center for Hydatidosis, Qinghai Province, China. The patient was a 24-yr-old male from pastoral area of Seda County, Sichuan Province, China in 2018. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7244840PMC

Genetic Diversity of Hepatic/Non-Hepatic Cystic Echinococcosis in Baqiyatallah Hospital, Tehran, Iran.

Iran J Parasitol 2020 Jan-Mar;15(1):130-137

The Laboratory of Pathology, Baqiyatallah Hospital, Tehran, Iran.

Background: Cystic echinococcosis (CE) is a worldwide zoonotic helminthic disease caused by the larval stage of . The infection is particularly important in terms of economic and medico-veterinary aspects in endemic areas including Iran. Considering the possibility of organ-tropism in strains, the present study was aimed to identify the genotypes of in different organs involved in patients, undergone surgery in Baqiyatallah Hospital, Tehran, Iran from 2005-2015. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7244847PMC

Experimentally Induced Cerebral Cystic Echinococcosis in Rats: A Suitable Animal Model for Cerebral Echinococcosis.

Iran J Parasitol 2020 Jan-Mar;15(1):101-108

Department of Pathobiology, School of Veterinary Medicine, Shahid Bahonar University of Kerman, Kerman, Iran.

Background: is a worldwide zoonotic cestode that lives mainly in the intestine of dog as definitive host. Its larval stage infects intermediate hosts and forms hydatid cysts mainly in the liver and lungs tissues and less other organs such as brain, eye and bone. In the experimental models, inoculation of protoscoleces into the peritoneum, thoracic cavity, subcutaneous and cerebrum produces hydatid cysts. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7244831PMC

Designing a Recombinant Multi-Epitope Antigen of to Diagnose Human Cystic Echinococcosis.

Iran J Parasitol 2020 Jan-Mar;15(1):1-10

Department of Medical Parasitology and Mycology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Background: Cystic echinococcosis can cause severe disease and probable death in humans. Epitopes of its antigens play a key role in the sensitivity and specificity of immunodiagnostic tests.

Methods: Epitope prediction software programs predict the most antigenic linear B-cell epitopes of AgB (8 kD), Ag5, and Ag95. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7244849PMC

and efficacies of inhibitors of the EGFR/MEK/ERK signaling in the treatment of alveolar echinococcosis.

Antimicrob Agents Chemother 2020 Jun 1. Epub 2020 Jun 1.

State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiamen, Fujian 361102, China.

Alveolar echinococcosis (AE), caused by the larval stage of the cestode , is a lethal disease in humans. Novel therapeutic options are urgently needed as the current chemotherapy displays limited efficiency in AE treatment. In this study, we assessed the and effects of the EGFR/MEK/ERK signaling inhibitors including BIBW2992, CI-1033 and U0126 on Our data showed that BIBW2992, CI-1033 and U0126 all displayed effects on the viability of the metacestode. Read More

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http://dx.doi.org/10.1128/AAC.00341-20DOI Listing

Molecular characterization of in livestock of Al-Madinah (Saudi Arabia).

J Helminthol 2020 Jun 1;94:e157. Epub 2020 Jun 1.

Faculty of Science, Ain Shams University, Cairo, Egypt.

Echinococcus granulosus is the causative agent of cystic echinococcosis, which has serious impacts on human and/or animal health, resulting in significant economic losses. Echinococcus granulosus comprises a number of intra-specific variants or strains at the genetic level. In Saudi Arabia, few studies were performed on genetic variations in Echinococcus species. Read More

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http://dx.doi.org/10.1017/S0022149X20000395DOI Listing

First report of Echinococcus canadensis (G6/G7) by sequence analysis from the Khyber Pakhtunkhwa province of Pakistan.

Acta Trop 2020 May 29;209:105559. Epub 2020 May 29.

Department of Veterinary Integrative Biosciences, College of Veterinary Medicine & Biomedical Sciences, Texas A&M University, College Station, Texas, United States of America.

Cystic echinococcosis (CE) is a zoonotic parasitic disease that can result in human and animal health problems globally. Although the disease is known to be endemic in Asia and the Middle East, there are few epidemiological studies on CE in Pakistan. The purpose of the present study was to identify the Echinococcus granulosus sensu lato species and genotypes contributing to human CE cases in the Khyber Pakhtunkhwa (KPK) province of Pakistan. Read More

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http://dx.doi.org/10.1016/j.actatropica.2020.105559DOI Listing

Contribution of Anthropogenic Factors and Climate Variables to Human Cystic Echinococcosis Mortality in Chile (2001-2011).

Vector Borne Zoonotic Dis 2020 Jun 1. Epub 2020 Jun 1.

Programa de Salud Ambiental, Facultad de Medicina, Instituto de Salud Poblacional ESP, Universidad de Chile, Santiago, Chile.

Here we assess the effect of weather and anthropogenic environmental variables, particularly urbanization, on cystic echinococcosis mortality in Chile from 2001 to 2011 using a nonparametric regression model, multivariate adaptive regression splines, and Poisson nonlinear regression models. This study integrated data from various sources on weather and anthropogenic variables. The canine population had the greatest influence on human cystic echinococcosis mortality during the period analyzed. Read More

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http://dx.doi.org/10.1089/vbz.2019.2610DOI Listing

Complete mitochondrial genome analysis confirms the presence of Echinococcus granulosus sensu lato genotype G6 in Nigeria.

Infect Genet Evol 2020 May 26;84:104377. Epub 2020 May 26.

State Key Laboratory of Veterinary Etiological Biology/National Professional Laboratory of Animal Hydatidosis/Key Laboratory of Veterinary Parasitology of Gansu Province/Lanzhou Veterinary Research Institute, CAAS, Lanzhou 730046, PR China. Electronic address:

Cystic echinococcosis (CE) is common in Africa especially in northern and eastern countries where it is highly prevalent and mainly caused by Echinococcus granulosus sensu stricto and Echinococcus granulosus sensu lato (G6/7). In a recent epidemiological survey in Nigeria, the G6/7 genotype was reportedly responsible for the majority of CE infection. In this study, considering the taxonomic challenges of the G6/7 genotype and the limitation of the cox1/nad1 genes in resolving the differences, we sequenced the complete mitochondrial (mt) genome of seven larval isolates of E. Read More

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http://dx.doi.org/10.1016/j.meegid.2020.104377DOI Listing
May 2020
3.015 Impact Factor

[Knowledge, attitude and practice of echinococcosis prevention and control, and their influencing factors among residents living in Seda County, Sichuan Province].

Authors:
Y L Lei C H Xiao X Ma

Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi 2020 Apr;32(3):273-281

Department of Health Related Social and Behavioral Science, West China School of Public Health, Sichuan University, Chengdu 610041, China.

Objective: To understand the status of knowledge, attitude and practice on echinococcosis prevention and control and investigate their influencing factors among residents living in Seda County of Sichuan Province, so as to provide a scientific basis for the further implementation of health education interventions in the county.

Methods: A multi-stage stratified random sampling method was employed on September 2018. Ten townships were randomly sampled, and 2 to 3 administrative villages were randomly sampled from each township. Read More

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http://dx.doi.org/10.16250/j.32.1374.2019291DOI Listing

[Spatial distribution characteristics of reported echinococcosis patients in Inner Mongolia Autonomous Region from 2013 to 2018].

Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi 2020 May;32(3):268-272

Inner Mongolia Autonomous Region Center for Comprehensive Disease Control and Prevention, Hohhot 010031, China.

Objective: To investigate the spatial distribution patterns and changing tendency of reported echinococcosis patients in Inner Mongolia Autonomous Region from 2013 to 2018, so as to provide the evidence for the management of echinococcosis in high-risk areas.

Methods: All data pertaining to echinococcosis patients in Inner Mongolia Autonomous Region were captured from the National Notifiable Communicable Disease Reporting System from 2013 to 2018 and analyzed using a spatial epidemiological method.

Results: The incidence of reported echinococcosis was 0. Read More

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http://dx.doi.org/10.16250/j.32.1374.2019210DOI Listing

Immunological responses and potency of the EG95NC recombinant sheep vaccine against cystic echinococcosis.

Parasitol Int 2020 May 26;78:102149. Epub 2020 May 26.

Research and Development of Recombinant Vaccine, Multi-Chemical Industry, Lot. 157, Z I, Sud-Ouest (ERAC) B.P.:278, 28810 Mohammedia, Morocco.

Cystic echinococcosis (CE) is a zoonotic disease caused by the cestode parasite Echinococcus granulosus. The disease has an important impact on human health as well as economic costs including the cost of treatment as well as loss of productivity for the livestock industry. In many parts of the world where the disease is endemic, sheep and other livestock play an important role in the parasite's transmission. Read More

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http://dx.doi.org/10.1016/j.parint.2020.102149DOI Listing

Dispersal and molecular characterisation of the Echinococcus granulosus (Batsch, 1786) complex isolated from various intermediate hosts in the Calabria region, southern Italy.

Folia Parasitol (Praha) 2020 May 22;67. Epub 2020 May 22.

Istituto Zooprofilattico Sperimentale del Mezzogiorno, Section of Catanzaro, Italy.

Cystic echinococcosis (CE) is a zoonotic disease caused by the tapeworms of the Echinococcus granulosus sensu lato complex, which have worldwide distribution. No data on the circulation of genotypes of the E. granulosus complex in intermediate hosts in endemic areas in Calabria are available. Read More

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http://dx.doi.org/10.14411/fp.2020.014DOI Listing

[Hepatic cystic and alveolar echinococcosis co-infections: a report of 3 cases].

Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi 2019 Oct;32(2):213-216

Qinghai Provincial People's Hospital, Xining 810000, China.

Objective: To investigate the diagnosis and surgical treatment of co-infection with hepatic cystic and alveolar echinococcosis, so as to provide insights into the diagnosis and treatment of these patients.

Methods: The clinical data of patients with co-infections of hepatic cystic and alveolar echinococcosis in Qinghai Provincial People's Hospital between 2017 and 2018 were retrospectively analyzed.

Results: Three patients were diagnosed with co-infection of hepatic cystic and alveolar echinococcosis. Read More

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http://dx.doi.org/10.16250/j.32.1374.2019091DOI Listing
October 2019

[Establishment of a recombinase-aided isothermal amplification assay for nucleic acid detection of and its preliminary application].

Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi 2020 Mar;32(2):168-173

National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention; Chinese Center for Tropical Diseases Research; WHO Collaborating Centre for Tropical Diseases; National Center for International Research on Tropical Diseases, Ministry of Science and Technology; Key Laboratory of Parasite and Vector Biology of National Health Commission, Shanghai 200025, China.

Objective: To establish a rapid nucleic acid detection technique for identification of based on the recombinase aided isothermal amplification assay (RAA) and assess its diagnostic efficiency.

Methods: The mitochondrial gene sequence of (GenBank accession number: AB018440) was used as a target sequence. The primers were designed according to the RAA reaction principle and synthesized, and RAA was performed using the generated primers. Read More

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http://dx.doi.org/10.16250/j.32.1374.2019284DOI Listing