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J Inflamm Res 2021 3;14:2403-2409. Epub 2021 Jun 3.

Department of Hepatopancreatobiliary Surgery, Affiliated Hospital of Qinghai University, Xining, Qinghai, 810001, People's Republic of China.

Objective: To explore the correlation between neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) with hepatic hydatid diseases.

Methods: The clinical data of 420 patients with hydatid disease who were treated in our hospital from October 2015 to October 2018 were collected from the database of our hospital. According to the postoperative pathological diagnosis, 200 patients were assigned into the alveolar echinococcosis (AE) group, and 220 patients were assigned into the cystic echinococcosis (CE) group. Read More

Acta Parasitol 2021 Jun 10. Epub 2021 Jun 10.

Parasitology, Zoology and Entomology Department, Faculty of Science (for Girls), Al-Azhar University, Nasr City, Cairo, Egypt.

Background: Echinococcosis is a common health problem in the Mediterranean and the Middle East, and manifests without any symptoms, even in the advanced stages.

Objective: The present study aimed to investigate the cell mediated-immunoregulatory milieu in rats' echinococcosis induced by three different viability status of Echinococcus granulosus especially in the semi-calcareous stage, which can be used as novel biomarkers to monitor disease progression and open the door to a deeper understanding of the pathways that could contribute to complementary echinococcosis therapies.

Materials And Methods: Rat infection with echinococcosis was induced by three different viable statuses of Echinococcus granulosus (G6) camel strain. Read More

Int J Infect Dis 2021 Jun 6. Epub 2021 Jun 6.

Department of Liver & Laparoscopic Surgery, Digestive & Vascular Surgery Center, 1(st)Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China; State Key Laboratory of Pathogenesis, Prevention, Treatment of High Incidence Diseases in Central Asia, Xinjiang Medical University, Urumqi 830054, China. Electronic address:

Objectives: We aimed to investigate the potential biomarker for distinguishing biological viability of hepatic echinococcosis.

Methods: We measured plasma concentrations of several cytokines and chemokines in patients with active and non-active cysts (HCE, n = 47), stable/progressive alveolar echinococcosis (HAE, n = 38) patients and their comparable infection-free volunteers (n = 48) through Luminex assay technique. Disease progression was staged according to the classification standard. Read More

J Cardiothorac Surg 2021 Jun 7;16(1):167. Epub 2021 Jun 7.

Department of Parasitology and Mycology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.

Background: Cystic echinococcosis (CE)/hydatidosis is an important neglected parasitic zoonotic disease caused by the metacestode of Echinococcus granulosus s.l. The present study was designed to identify the pulmonary CE species/genotypes in isolated human underwent to surgery in our center in Southern Iran. Read More

Exp Parasitol 2021 Jun 8:108121. Epub 2021 Jun 8.

Department of Pharmacy, The First Affiliated Hospital, Xinjiang Medical University, Urumqi, Xinjiang, PR China; State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, PR China. Electronic address:

Cystic echinococcosis (CE), a parasitic larval cystic stage of a small taeniid-type tapeworm (Echinococcus granulosus), causes illness in intermediate hosts and has become a threat to global public health. Currently, chemical compounds recommended by the WHO targeting CE are albendazole and mebendazole, however, none of them shows enhanced efficacy. Novel molecular compounds are urgently required to treat this disease. Read More

Heliyon 2021 May 22;7(5):e07086. Epub 2021 May 22.

Research Center for Prevention of Cardiovascular Disease, Institute of Endocrinology and Metabolism, Iran University of Medical Sciences (IUMS), Tehran, Iran.

Hydatid disease (HD), also known as echinococcal disease or echinococcosis, is a worldwide zoonosis with a wide geographic distribution. It can be found in almost all parts of the body and usually remains silent for a long period of time. Clinical history can be varied based on the location, size, host immune response, and complications. Read More

Infect Dis Poverty 2021 Jun 5;10(1):82. Epub 2021 Jun 5.

Department of Parasitic Diseases, Sichuan Provincial Center for Disease Control and Prevention, No.6 Zhongxue Road, Chengdu, 610041, People's Republic of China.

Background: Echinococcosis is a global zoonotic parasitic disease caused by Echinococcus larvae. This disease is highly endemic in Sichuan Province, China. This study investigates the prevalence and spatial distribution characteristics of human echinococcosis at the township level in Sichuan Province, geared towards providing a future reference for the development of precise prevention and control strategies. Read More

J Res Med Sci 2021 28;26. Epub 2021 Jan 28.

Clinical Informationist Research Group, Health Information Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.

Hydatid cyst (HC) is a serious health problem in endemic areas. Liver and lung are the most common involved organs while the involvement of muscles, heart, kidney, brain, and spleen is rare. The involvement of these rare locations for HC is mostly in association with infestation of common sites. Read More

J Biomed Nanotechnol 2021 May;17(5):910-920

Department of Immunology, College of Basic Medicine, Xinjiang Medical University, Xinjiang 830011, PR China.

Cystic Echinococcosis (CE) is caused by ), which endangers the health of the intermediate host. Therefore, effective canid vaccines against infection are urgently needed to reduce the incidence of this disease. In the present work, the aim was to predict epitopes in four vaccine candidate antigens (VCAs) in as a basis to design a multi-epitope canine-directed vaccine. Read More

Parasit Vectors 2021 Jun 3;14(1):295. Epub 2021 Jun 3.

Center of Scientific Technology of Ningxia Medical University, Yinchuan, 750004, Ningxia Hui Autonomous Region, People's Republic of China.

Background: Cystic echinococcosis (CE) is a parasitic disease that is caused by Echinococcus granulosus (Eg). The recombinant Echinococcus granulosus antigen P29 (rEg.P29) was shown to confer effective immunity to sheep and mice during E. Read More

Clin Microbiol Rev 2021 Jun 2:e0029020. Epub 2021 Jun 2.

Department of Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.

Echinococcosis is considered a cosmopolitan zoonosis caused by different species of small taeniid tapeworms of the genus and is regarded as a neglected zoonosis. Cystic and alveolar echinococcoses are endemic diseases of Tibetan, Pamir, and Iranian plateaus. All of the countries within the Iranian plateau are affected by echinococcosis. Read More

Acta Trop 2021 May 28;221:105989. Epub 2021 May 28.

Institute of Parasitic Diseases, Sichuan Center for Disease Control and Prevention, Chengdu, Sichuan, China.

The prevalence of E. multilocularis is a major public health problem in China. To better understand the molecular epidemiology and evolutionary patterns of E. Read More

J Med Case Rep 2021 May 28;15(1):311. Epub 2021 May 28.

Inflammatory Lung Disease Research Center, Razi Hospital, Guilan University of Medical Sciences, Rasht, Iran.

Background: Hydatid cysts are fluid-filled sacs containing immature forms of parastic tapeworms of the genus Echinococcus. The most prevalent and serious complication of hydatid disease is intrabiliary rupture, also known as cystobiliary fistulae. In this study, a sporadic case of biliary obstruction, cholangitis, and septicemia is described secondary to hydatid cyst rupture into the common bile duct and intraperitoneal cavity. Read More

Acta Trop 2021 May 26;221:105985. Epub 2021 May 26.

Hacettepe University, Faculty of Pharmacy, Department of Analytical Chemistry, Ankara 06100, Turkey; Hacettepe University, Faculty of Pharmacy, Bioanalytic and Omics Laboratory, Ankara 06100, Turkey. Electronic address:

Cystic Echinococcosis (CE) is one of the life-threatening diseases worldwide. It is a parasitic zoonosis caused by tapeworms of the species Echinococcus granulosus sensu lato (s.l). Read More

Acta Trop 2021 May 25;221:105982. Epub 2021 May 25.

Sichuan Center for Animal Disease Control and Prevention, Chengdu, China.

Echinococcosis is the most common parasitic disease in the Tibetan Plateau, placing a large disease burden on the local population. Shiqu County, located in western Sichuan Tibetan region, had a particularly high prevalence rate of cystic echinococcosis (CE) and alveolar echinococcosis (AE) in previous surveys. From 2015 to 2018, a population-based field survey was conducted to explore the epidemic situation. Read More

Parasitol Res 2021 May 27. Epub 2021 May 27.

Scientific Technology Center of Ningxia Medical University, Yinchuan, 750004, Ningxia, China.

Several strategies exist to prevent and control echinococcosis, a global parasitic disease. However, most treatments are ineffective and adverse effects are common. Therefore, we aimed to screen protoscolex antigen molecules of Echinococcus granulosus to identify a diagnostic biomarker for hydatid disease. Read More

Biomed Res Int 2021 7;2021:6628814. Epub 2021 May 7.

State Key Laboratory of Pathogenesis, Prevention, Treatment of High Incidence Diseases in Central Asia, Xinjiang Medical University, Urumqi 830054, China.

Objective: Alveolar echinococcosis (AE) is a zoonosis caused by the larval stage of the metacestode with a tumor-like behavior in the targeted organ, especially in the liver. Surgery with albendazole is first-line modality for AE. Drug discontinuation is usually based upon the parasitic viability shown by the positron emission tomography (PET) scan. Read More

EFORT Open Rev 2021 Apr 1;6(4):288-296. Epub 2021 Apr 1.

First Department of Orthopaedics, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece.

Echinococcosis or hydatid disease affecting the spine is an uncommon manifestation of infection of the spine.More commonly found in endemic areas, it causes significant morbidity and mortality as it grows slowly and produces symptoms mainly by compressing the spinal cord.As diagnostic methods are non-specific, diagnosis and management are usually delayed until the disease is advanced, thereby therapy is usually unlikely. Read More

Vet Parasitol 2021 Jul 9;295:109450. Epub 2021 May 9.

Epidemiology and Diagnostics Section, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.

Taeniosis/cysticercosis and echinococcosis are neglected zoonotic helminth infections with high disease burden caused by tapeworms which circulate between definitive and intermediate host reflecting a predator-prey interaction. Taeniid eggs can remain vital for months, allowing arthropods to mechanically transport them to intermediate hosts. However, the multiple routes that arthropods provide as carriers of taeniid eggs are still often unregarded or not considered. Read More

Am J Trop Med Hyg 2021 May 24. Epub 2021 May 24.

2Department of Clinical, Surgical, Diagnostic and Pediatric Sciences, University of Pavia, Pavia, Italy.

We evaluated the performance of a commercial rapid diagnostic test (RDT) in a field setting for the diagnosis of abdominal cystic echinococcosis (CE) using sera collected during an ultrasound population screening in a highly endemic region of the Peruvian Andes. Abdominal CE was investigated by ultrasonography. Sera collected from individuals with abdominal CE (cases) and age- and gender-matched volunteers with no abdominal CE (controls) were tested independently in two laboratories (Peru and Italy) using the VIRapid® HYDATIDOSIS RDT and RIDASCREEN® Echinococcus IgG enzyme-linked immunosorbent assay. Read More

Microb Pathog 2021 May 20;157:104962. Epub 2021 May 20.

Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

Cystic echinococcosis, an important zoonotic disease, is caused by Echinococcus granulosus. MicroRNAs are a small group of single-stranded noncoding RNAs, which play an effective role in biological processes. This study aimed at comparing the expression levels of miR-146a and miR-155 in the plasma of patients with hydatidosis and healthy individuals. Read More

Chin Neurosurg J 2021 May 21;7(1):30. Epub 2021 May 21.

Department of Neurosurgery, The First Teaching Hospital of Xinjiang Medical University, Xinjiang, 830054, China.

Background: To explore central nervous system (CNS) involvement in this disease, from the perspectives of diagnosis, treatment, and misdiagnosis METHODS: Twenty-eight patients with CNS echinococcosis were included in this retrospective study, including 18 males (64.3%) and 10 (35.7%) females. Read More

Ann Surg Treat Res 2021 May 29;100(5):270-275. Epub 2021 Apr 29.

Department of General Surgery, Cukurova University Faculty of Medicine, Saricam, Turkey.

Purpose: The aim of the present study is to describe the cavity-reducing internal capitonnage technique that we used for the surgical therapy of liver hydatid cyst, and contribute to the literature by presenting the short- and long-term outcomes of the patients who were operated on with this technique.

Methods: A drainage and internal capitonnage technique was performed on 12 cases due to liver hydatid cyst in our clinic between January 2016 and December 2019.

Results: The mean age of cases was 36. Read More

Parasit Vectors 2021 May 19;14(1):262. Epub 2021 May 19.

Facultad de Ciencias Veterinarias, Universidad Nacional de La Pampa, General Pico, Provincia de La Pampa, Argentina.

Background: Cystic echinococcosis (CE) is a parasitic zoonosis caused by infection with the larval stage of Echinococcus granulosus (s.l.). Read More

Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi 2020 Sep;33(2):213-217

Qinghai Provincial People's Hospital, China.

The long-term use of benzimidazoles for the treatment of echinococcosis may cause multiple adverse reactions and low compliance. A search for novel agents, as an alternative of benzimidazoles, is therefore of great significance for the treatment of echinococcosis. This review focuses on the progress of researches on non-benzimidazoles for the clinical treatment of echinococcosis, including anti-parasitic agents, anti-proliferative agents and plant extracts, so as to provide insights into the further development of non-benzimidazoles. Read More

Radiol Case Rep 2021 Jul 30;16(7):1712-1714. Epub 2021 Apr 30.

Department of Radiology, Faculty of Medicine, Mohammed VI University of Health Sciences/Cheikh Khalifa International University Hospital, Casablanca, Morocco.

Osseous echinococcosis is a relatively rare entity and that of the rib is even rare. Few cases of costal echinococcosis have been reported in the literature so far. We report a case of a recurrent costovertebral hydatidosis with epidural extension in a 49-year-old man who presented with paraparesis and back pain. Read More

J Hematol 2021 Apr 27;10(2):71-75. Epub 2021 Apr 27.

Division of Hematology, Department of Medicine, Jewish General Hospital, McGill University, Montreal, QC H3T 1E2, Canada.

We present a case of immune thrombocytopenic purpura (ITP), which leads to the diagnosis of severe cystic echinococcosis. Our patient presented with platelets of 5 × 10/L, and investigations uncovered multiple large echinococcal hepatic cysts, the largest of which measured 19.4 × 15 × 12 cm, and peritoneal implants. Read More

Acta Chir Belg 2021 Jun 2:1-4. Epub 2021 Jun 2.

Faculty of Medicine, University of Ostrava, Ostrava, The Czech Republic.

Background: Solitary fibrous tumour of the liver is a rare mesenchymal tumour, occurring usually in women and with various symptomatology. The symptoms mostly result from pressure of the tumour mass on surrounding organs. Due to unknown biological behaviour and gradual increase of tumour volume, surgical resection is mostly the preferred treatment option. Read More

Parasitology 2021 May 18:1-7. Epub 2021 May 18.

Department of Parasitology, Faculty of Veterinary Medicine, Atatürk University, Erzurum25240, Turkey.

Echinococcosis, caused by larval stage of the genus Echinococcus, is one of the most important zoonotic diseases worldwide. The purpose of this study was to determine the presence and prevalence of Echinococcus species in stray dogs of Erzurum, a highly endemic region for cystic echinococcosis (CE) and alveolar echinococcosis (AE) in Turkey. The study samples consisted of 446 stray dog faecal specimens collected from an animal shelter in Erzurum, Turkey, between October 2015 and February 2016. Read More

Parasit Vectors 2021 May 17;14(1):257. Epub 2021 May 17.

Division of Virology, Department of Pathobiology, School of Veterinary Medicine, Shiraz University, Shiraz, Iran.

Background: Novel and more efficient compounds are urgently required for medical treatment of cystic echinococcosis (CE). Germinative cell culture of Echinococcus granulosus could be used for anti-echinococcosis agent tests and other biological studies on CE. This study was performed to establish an in vitro cell culture model for E. Read More