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    Experimental Nanopulse Ablation of Multiple Membrane Parasite on Ex Vivo Hydatid Cyst.
    Biomed Res Int 2018 7;2018:8497283. Epub 2018 Feb 7.
    Hepatobiliary & Hydatid Department, Digestive and Vascular Surgery Centre, Xinjiang Key Laboratory of Echinococcosis, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang 830011, China.
    The impact of ultrashort nanopulse on cellular membrane is of biological significance and thus has been studied intensively. Different from cell study, this ex vivo study aims to investigate the biological effects of nanosecond pulsed electric field (nsPEF) on an independent multimembrane parasite, human hydatid cyst, to observe the unique influence of nanopulse on macromembrane structure, permeabilization, and biochemistry. The 300 ns nsPEF was delivered on an experimental model of single human hydatid cyst ex vivo with eight different parameters. Read More

    Proteome evaluation of human cystic echinococcosis sera using two dimensional gel electrophoresis.
    Gastroenterol Hepatol Bed Bench 2018 ;11(1):75-82
    School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical. Sciences, Tehran, Iran.
    Aim: Detection of protein expression changes in human cystic echinococcosis sera by 2D gel electrophoresis.

    Background: Diagnosis and successful treatment of cystic echinococcosis (CE) is a major challenge, up to now. Identification of related expressed proteins using proteomics tools and bioinformatics analysis of patients' sera have not been investigated, so far. Read More

    Modelling the regional vulnerability to Echinococcosis based on environmental factors using fuzzy inference system: A case study of Lorestan Province, west of Iran.
    Electron Physician 2017 Dec 25;9(12):6094-6101. Epub 2017 Dec 25.
    Student Research Committee, Fasa University of Medical Sciences, Fasa, Iran.
    Background And Aim: Echinococcosis as a zoonosis disease is one of the most important parasitic helminth that is affected by many risk factors such as the environmental factors. Thus, we predicted the regional vulnerability to Echinococcosis based on environmental factors using a fuzzy inference system (FIS) in Lorestan Province.

    Methods: Our study was cross-sectional study on 200 patients from Lorestan Province (west of Iran) who underwent surgery for hydatidosis between October 2005 and November 2014. Read More

    Evaluation of Echinococcus granulosus recombinant EgAgB8/1, EgAgB8/2 and EPC1 antigens in the diagnosis of cystic echinococcosis in buffaloes.
    Vet Parasitol 2018 Mar 4;252:29-34. Epub 2018 Feb 4.
    Division of Livestock Economics, Statistics and Information Technology, ICAR-Indian Veterinary Research Institute, Izatnagar, U.P, India.
    Three recombinant proteins of Echinococcus granulosus including two antigen B sub-units EgAgB8/1 and EgAgB8/2 and Echinococcus protoscolex calcium binding protein 1 (EPC1) were expressed in prokaryotic expression vectors. The diagnostic potential of these three recombinant proteins was evaluated in the detection of cystic echinococcosis in buffaloes in IgG-ELISA. The EgAgB8/1 and EgAgB8/2 recombinant proteins reacted fairly with the hydatid infected buffaloes with sensitivity of 75. Read More

    Reply letter to: Letter to the editor on the article "The seroprevalence rate and population genetic structure of human cystic echinococcosis in the Middle East: A systematic review and meta-analysis".
    Int J Surg 2018 Mar 16. Epub 2018 Mar 16.
    Research Center for Evidence Based Medicine (RCEBM), Tabriz University of Medical Sciences, Tabriz, Iran; Infectious and Tropical Disease Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address:

    Heterologous expression of three antigenic proteins from Angiostrongylus cantonensis: ES-7, Lec-5, and 14-3-3 in mammalian cells.
    Mol Biochem Parasitol 2018 Mar 16. Epub 2018 Mar 16.
    Laboratorio de Parasitologia Molecular, Instituto de Pesquisas Biomédicas and Laboratorio de Biologia Parasitaria, Faculdade de Biociências da Pontifícia Universidade Catolica do Rio Grande do Sul (PUCRS), Av Ipiranga 6690, 90690-900, Porto Alegre, RS, Brazil.
    Angiostrongylus cantonensis is a parasitic nematode and the main causative agent of human cerebral eosinophilic meningoencephalitis (EoM). A definitive diagnosis of EoM usually requires serologic or molecular analysis of the patient's clinical sample. Currently, a 31 kDa antigen is used in immunological tests for this purpose, however as a crude antigen preparation it may present cross-reactivity with other helminthic infections, especially echinococcosis. Read More

    A study to assess the awareness of risk factors of cystic echinococcosis in Turkey.
    Saudi Med J 2018 Mar;39(3):280-289
    Department of Public Health, Faculty of Health Sciences, University of Karamanoglu Mehmetbey, Karaman, Turkey. E-mail.
    Objectives: To determine the knowledge, attitudes, practices, and awareness for risk factors associated with cystic echinococcosis (CE) among animal breeders, nurses, nursing students, dietitians, food professionals and other public groups in Turkey. Methods: Questionnaire forms were prepared in compliance with the individuals' diversity, and a survey was created about agents, transmission modes, epidemiology, treatment, and risk factors for CE. The descriptive survey was performed between May 2015 and May 2016 by face-to-face communication. Read More

    Three-dimensional hepatocyte culture system for the study of Echinococcus multilocularis larval development.
    PLoS Negl Trop Dis 2018 Mar 14;12(3):e0006309. Epub 2018 Mar 14.
    State Key Laboratory of Veterinary Etiological Biology, Key Laboratory of Veterinary Parasitology of Gansu Province, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, Gansu, P. R. China.
    Background: Hepatocyte-based metacestode culture is an attractive method to study alveolar echinococcosis (AE), but it is limited by the relatively short lifespan of cultured hepatocytes in maintaining their normal function.

    Methodology/principal Findings: We describe a three-dimensional (3D) hepatic culture system developed from co-cultured hepatocytes and mesenchymal stem cells using a collagen scaffold to study the development of Echinococcus multilocularis larvae. This 3D culture system preserved the function of hepatocytes for a longer period of time than their monolayer counterparts, with albumin secretion, 7-ethoxyresorufin O-deethylation activity, urea synthesis, CYP3A4 and CYP2D6 activity being highly preserved for 21-28 days. Read More

    Alveolar echinococcosis in the head of pancreas: A case report.
    Medicine (Baltimore) 2018 Mar;97(11):e0072
    Department of Biliary Surgery, West China Hospital of Sichuan University.
    Rationale: Pancreatic alveolar echinococcosis (AE) is an exceptionally rare disease; no more than 10 cases have been published to date. It is characterized as extensive local tissue infringement and destruction; thus, extended surgical resection, such as duodenopancreatectomy, is often needed to obtain a negative resection margin so as to improve the long-term outcome and prognosis.

    Patient Concerns: A middle-aged Tibetan man was admitted due to a 16-year history of recurrent pain in the right upper abdomen. Read More

    [Advances in surgical operation treatment of hepatic echinococcosis].
    Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi 2018 Feb;30(1):104-107
    Qinghai People's Hospital, Xining 810000, China.
    Echinococcosis is a zoonotic parasitic disease caused by the larvae ofand, which mainly violate the liver. And the surgical treatment is an important method to cure the disease at present. However, there are many surgical methods for the treatment of hepatic echinococcosis, and different surgeries with different indications and risks. Read More

    [Study on the ARIMA model application to predict echinococcosis cases in China].
    Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi 2018 Feb;30(1):47-53
    National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention; Key Laboratory for Parasitology and Vector Biology, National Health and Family Planning Commission, WHO Collaborating Center for Tropical Diseases, National Center for International Research on Tropical Diseases, China.
    Objective: To predict the monthly reported echinococcosis cases in China with the autoregressive integrated moving average (ARIMA) model, so as to provide a reference for prevention and control of echinococcosis.

    Methods: SPSS 24.0 software was used to construct the ARIMA models based on the monthly reported echinococcosis cases of time series from 2007 to 2015 and 2007 to 2014, respectively, and the accuracies of the two ARIMA models were compared. Read More

    Increase of Vascular Endothelial Growth Factor and Decrease of MCP-1 and Some Updated Epidemiology Aspects of Cystic Echinococcosis Human Cases in Calabria Region.
    Mediators Inflamm 2018 14;2018:4283672. Epub 2018 Jan 14.
    Institute of Microbiology, Department of Health Sciences, "Magna Græcia" University of Catanzaro, Viale Europa, 88100 Catanzaro, Italy.
    We aim to investigate some of the pathogenetic mediators of the human echinococcosis and to obtain updated epidemiological findings on cases of echinococcosis in Calabria, Southern Italy. Echinococcosis diagnosis was based on imaging, serological investigations, and molecular assay. Indeed, real-time PCR indicated the presence of G2/G3 genotypes ofcomplex. Read More

    Plasma IL-23 and IL-5 as surrogate markers of lesion metabolic activity in patients with hepatic alveolar echinococcosis.
    Sci Rep 2018 Mar 13;8(1):4417. Epub 2018 Mar 13.
    State Key Laboratory of Pathogenesis, Prevention, Treatment of High Incidence Diseases in Central Asia, First Affiliated Hospital of Xinjiang Medical University, Urumqi, China.
    Fluorodeoxyglucose (FDG) uptake by alveolar echinococcosis (AE) liver lesions is a signal of their metabolic activity and of disease progression. In order to find a surrogate marker for this status, we investigated whether parameters of the peripheral and/or periparasitic immune responses were associated with metabolic activity in a prospective case-control study of 30 AE patients and 22 healthy controls. Levels of 18 cytokines and chemokines, representative of innate and adaptive immune responses, were assessed in plasma and peripheral cells of two groups of patients with (MAAE) and without (MIAE) metabolically active lesions, and in the liver of MAAE patients. Read More

    Hydatid disease: MR imaging of calvarium and superior sagittal sinus involvement.
    Neuroradiol J 2018 Jan 1:1971400918764130. Epub 2018 Jan 1.
    3 Department of Neurosurgery, Bahçeşehir University School of Medicine, Göztepe Medical Park Hospital, Istanbul, Turkey.
    Extra-axial hydatid disease (HD) is rare and may create a diagnostic challenge. Herein, we report an extremely rare case of calvarial HD with superior sagittal sinus invasion and an extension to the scalp with unusual magnetic resonance imaging findings simulating osteomyelitis and abscess. Recognition of detached endocystic membranes was the most important clue for the correct diagnosis. Read More

    Computed Tomography Perfusion Imaging for the Diagnosis of Hepatic Alveolar Echinococcosis.
    Eurasian J Med 2018 Feb 29;50(1):1-5. Epub 2017 Dec 29.
    Department of Gastroenterology, Atatürk University School of Medicine, Erzurum, Turkey.
    Objective: Alveolar echinococcosis (AE) is a rare life-threatening parasitic infection. Computed tomography perfusion (CTP) imaging has the potential to provide both quantitative and qualitative information about the tissue perfusion characteristics. The purpose of this study was the examination of the characteristic features and feasibility of CTP in AE liver lesions. Read More

    High density of fox and cat faeces in kitchen gardens and resulting rodent exposure to Echinococcus multilocularis and Toxoplasma gondii.
    Folia Parasitol (Praha) 2018 Mar 8;65. Epub 2018 Mar 8.
    University of Reims Champagne-Ardenne, EA 3800 PROTAL, SFR Cap Sante, Reims cedex, France.
    The faeces of the red fox, Vulpes vulpes (Linnaeus), and the domestic cat, Felis catus (Linnaeus), can be responsible for spreading eggs of Echinococcus multilocularis Leuckart, 1863 and oocysts of Toxoplasma gondii (Nicolle et Manceaux, 1908) into the environment. The accidental ingestion of these eggs or oocysts, through consumption of raw fruits or vegetables grown in or in contact with contaminated soil, can lead to alveolar echinococcosis (AE) or toxoplasmosis in humans. The present study provides a quantitative assessment of the faecal deposition by foxes and cats in kitchen gardens where fruits and vegetables are grown and its consequences for zoonosis transmission. Read More

    Impact of disposing stray dogs on risk assessment and control of Echinococcosis in Inner Mongolia.
    Math Biosci 2018 Mar 8;299:85-96. Epub 2018 Mar 8.
    LAMPS, Department of Mathematics and Statistics, York university, 4700 Keele Street, Toronto, ON M3J 1P3, Canada.
    Echinococcosis has been recognized as one of the most important helminth zoonosis in China. Available models always consider dogs as the mainly definitive hosts. However, such models ignore the distinctions between domestic dogs and stray dogs. Read More

    Environmental risk factors and changing spatial patterns of human seropositivity for Echinococcus spp. in Xiji County, Ningxia Hui Autonomous Region, China.
    Parasit Vectors 2018 Mar 9;11(1):159. Epub 2018 Mar 9.
    Research School of Population Health, The Australian National University, Canberra, Australian Capital Territory, 0200, Australia.
    Background: Human echinococcoses are parasitic helminth infections that constitute a serious public health concern in several regions across the world. Cystic (CE) and alveolar echinococcosis (AE) in China represent a high proportion of the total global burden of these infections. This study was conducted to predict the spatial distribution of human seropositivity for Echinococcus species in Xiji County, Ningxia Hui Autonomous Region (NHAR), with the aim of identifying communities where targeted prevention and control efforts are required. Read More

    Mitochondrial genome data confirm that yaks can serve as the intermediate host of Echinococcus canadensis (G10) on the Tibetan Plateau.
    Parasit Vectors 2018 Mar 9;11(1):166. Epub 2018 Mar 9.
    State Key Laboratory of Veterinary Etiological Biology/Key Laboratory of Veterinary Parasitology of Gansu Province/Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, 730046, Gansu Province, People's Republic of China.
    Background: Cervids used to be considered the only animal intermediate hosts of the G10 genotype of Echinococcus canadensis. Yaks are often herded in the Qinghai-Tibet Plateau, China, where echinococcosis remains prevalent. However, no E. Read More

    Surgical overview of cardiac echinococcosis: a rare entity.
    Interact Cardiovasc Thorac Surg 2018 Mar 7. Epub 2018 Mar 7.
    Department of Cardiovascular and Thoracic Surgery, U.N. Mehta Institute of Cardiology and Research Center (Affiliated with B.J. Medical College), Ahmedabad, Gujarat, India.
    Objectives: The purpose of this study was to describe our experience with the presentation and management of cardiac echinococcosis and the outcomes.

    Methods: We performed a retrospective study from January 2012 to September 2017 in 10 patients operated on for cardiac echinococcosis. There were 6 men and 4 women; the age range was 17-55 years (mean age, 35. Read More

    [Multidisciplinary management of a giant hepatic hydatidosis].
    Rev Med Liege 2018 Feb;73(2):65-71
    Service de Chirurgie Abdominale et Transplantation, CHU Sart Tilman, Liège, Belgique.
    Cystic echinococcosis or hydatidosis, is a zoonosis caused by larval stages of Echinococcus granulosus that can be encountered in Belgium in patients originating from endemic countries. The liver is the most commonly affected organ. In this paper, the authors describe the multidisciplinary management of this pathology based on the clinical case of a patient suffering from a 28 cm cystic echinococcosis treated by combination of albendazole and liver resection. Read More

    Primary hydatid cyst in the posterior thigh, and its percutaneous treatment.
    Skeletal Radiol 2018 Mar 7. Epub 2018 Mar 7.
    Department of Pathology, Faculty of Medicine, Health Science University, Adana, Turkey.
    Hydatid cyst (echinococcosis) is an endemic parasitic disease, usually encountered in those dealing with agriculture and livestock. The most frequently affected organs are the liver and the lungs. The disease is very rarely encountered in soft tissues. Read More

    [Progress in researches of benzimidazole in treatment of echinococcosis].
    Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi 2017 Jun;29(4):530-533
    Graduate School of Qinghai University, Xining 810000, China.
    Echinococcosis is a severe zoonosis parasitic disease and mainly caused by the larvae ofand. Because of the limitation of operation level, such as recurrence and death, the drug treatment is still the most important method in our country. Meanwhile, the annual number of drug treatments is far greater than surgical treatments. Read More

    The effects of taxanes, vorinostat and doxorubicin on growth and proliferation ofmetacestodes assessed with magnetic resonance imaging and simultaneous positron emission tomography.
    Oncotarget 2018 Feb 10;9(10):9073-9087. Epub 2018 Jan 10.
    Institute for Tropical Medicine, Eberhard Karls University, Tübingen, Germany.
    Cytostatic drugs used in cancer therapy were evaluated for their capacity to inhibitmetacestode growth and proliferation. Metacestode tissues were exposedto docetaxel, doxorubicin, navelbine, paclitaxel, and vorinostat for 1 week, then incubated in drug-free culture, and thereafter metacestodes were injected into the peritoneum of. Magnetic resonance imaging (MRI) and simultaneous positron emission tomography (PET) were applied to monitorgrowth of drug-exposedin. Read More

    Laparoscopic surgery for primary ovarian and retroperitoneal hydatid disease: A case report.
    Medicine (Baltimore) 2018 Jan;97(3):e9667
    Department of Gynecology, the Second Affiliated Hospital of Kunming Medical University, Kunming, China.
    Rationale: Cystic echinococcosis (CE) is a parasitic zoonosis caused by echinococcus larvae. Manifestations of the disease include a severe damage to the liver and lung. Damages to the mesentery, omentum, spleen, brain, heart, bone, thyroid, kidney, and uterus are rarely observed. Read More

    Degree of calcification and cyst activity in hepatic cystic echinococcosis in humans.
    Acta Trop 2018 Feb 24;182:135-143. Epub 2018 Feb 24.
    Department of Life and Environmental Sciences, Biomedical Section, Cagliari University, Cittadella Universitaria di Monserrato, Strada Provinciale Monserrato-Sestu km 0.700, Monserrato, Cagliari, Italy.
    To evaluate the relationship between cyst activity and calcification degree in cystic echinococcosis (CE) in humans, 99 hepatic cysts at successive stages of involution, surgically excised from 72 Sardinian patients, have been analyzed. Cysts were classified into 4 groups according to calcification extent: CALC 0 (no calcification); CALC 1 (scattered punctate calcifications); CALC 2 (large coarse segmental/partial calcifications); CALC 3 (complete or nearly complete circumferential ring of calcification up to thick wall of osseous consistency/calcified content of cyst). In addition the possible correlation with antibody response has been explored analyzing IgG1, IgG4 and IgE produced against somatic PSCAg. Read More

    Human cystic echinococcosis in Turkey: a preliminary study on DNA polymorphisms of hydatid cysts removed from confirmed patients.
    Parasitol Res 2018 Apr 23;117(4):1257-1263. Epub 2018 Feb 23.
    Faculty of Medicine, Department of Radiology, Hacettepe University, Ankara, Turkey.
    Cystic echinococcosis caused by the larval stages of Echinococcus granulosus sensu lato s.l is endemic in Turkey with a high public health impact particularly in rural areas. The aim of this study was to investigate the genetic variation and population structure of E. Read More

    Spatiotemporal patterns and environmental drivers of human echinococcoses over a twenty-year period in Ningxia Hui Autonomous Region, China.
    Parasit Vectors 2018 Feb 22;11(1):108. Epub 2018 Feb 22.
    Research School of Population Health, The Australian National University, Canberra, ACT, Australia.
    Background: Human cystic (CE) and alveolar (AE) echinococcoses are zoonotic parasitic diseases that can be influenced by environmental variability and change through effects on the parasites, animal intermediate and definitive hosts, and human populations. We aimed to assess and quantify the spatiotemporal patterns of human echinococcoses in Ningxia Hui Autonomous Region (NHAR), China between January 1994 and December 2013, and examine associations between these infections and indicators of environmental variability and change, including large-scale landscape regeneration undertaken by the Chinese authorities.

    Methods: Data on the number of human echinococcosis cases were obtained from a hospital-based retrospective survey conducted in NHAR for the period 1 January 1994 through 31 December 2013. Read More

    [Evaluation on application of China Disease Prevention and Control Information System of Hydatid Disease II System integration and simulation tests].
    Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi 2017 Jun;29(3):324-328
    National Institute of Parasitic Diseases, China CDC, Key Laboratory of Parasite and Vector Biology, National Health and Family Planning Commission, WHO Collaborating Center for Tropical Diseases, Shanghai 200025, China.
    Objective: To report the integrated progress of the hydatid disease information management system, and to provide the reference for further system improvements by analysis of results on simulation test feedback.

    Methods: The work of institutional code matching by collecting fundamental and integrated information of the system in epidemic areas of hydatid disease was carried out, and professional control agencies were selected to carry out the simulation test.

    Results: The results of agencies code matching at stage indicated the average completion rate was 94. Read More

    [Epidemic status of alveolar echinococcosis in Tibetan children in south Qinghai Province].
    Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi 2017 Feb;29(1):53-58
    Qinghai Provincial People's Hospital, Qinghai Province, Xining 810007, China.
    Objective: To understand the epidemic status of alveolar echinococcosis in Tibetan children in south Qinghai Province.

    Methods: The imageology and serology methods were applied to investigate the epidemic status of alveolar echinococcosis of elementary school students in Yushu and Guoluo prefectures.

    Results: Totally 19 629 children were investigated by the portable B ultrasound and 221 children were diagnosed as alveolar echinococcosis with the morbidity of 1. Read More

    [Correlation between HLA-DB1 genes and susceptibility to echinococcosis in Tibetan population in Tibetan Plateau].
    Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi 2017 Oct;29(5):602-606
    Fourth Hospital of PLA.
    Objective: To determine the susceptibility genes and resistance genes in HLA-DRB1 alleles in Tibetan patients with cystic and alveolar hydatid diseases, so as to provide the references for the research of the genetic characteristics and infection mechanism of Tibetan hydatid diseases.

    Methods: The case control method was applied. The Tibetan patients with cystic and alveolar hydatid diseases (63 and 73 cases respectively) in Yushu and Guoluo Tibetan Autonomous Prefecture, and unrelated healthy people (60 cases) in this area were selected as the study subjects. Read More

    [Evaluation of ELISA kit for detection of serum specific IgG antibodies againstin diagnosis of human cysticercosis].
    Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi 2017 Mar;29(2):228-230
    Sichuan Center for Diseases Control and Prevention, Chengdu 610041, China.
    Objective: To evaluate the ELISA kit for detection of IgG antibodies againstcysticercus in humans, so as to provide a reference for its application in clinical practice.

    Methods: The sera collected from the patients with neurocysticercosis, echinococcosis, taeniasis and healthy people, respectively, were checked by ELISA for specific IgG antibodies againstcysticercus, as described in the instruction of the kit.

    Results: Of the 30 patients with neurocysticercosis at active stage, 28 showed seropositive reaction, indicating a sensitivity of 93. Read More

    [Epidemiological characteristics of canineinfection in Qinghai-Tibet Plateau of China].
    Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi 2017 Apr;29(2):129-138
    Yunnan Institute of Parasitic Diseases, China.
    The Qinghai-Tibet Plateau is known as one of the highest endemic areas of echinococcosis. However, the dog infection rates ofin the plateau regions were similar to other non-Tibetan areas with the high endemic, and most of the rates were below 40%. The infected dogs withwere ubiquitous in Ganzi Prefecture of Sichuan Province and Qinghai Province where many survey data were done and available, which was much different from those in non-Ti-betan areas where the geographical distribution of dogs infected withwas sporadic. Read More

    The choose of different surgical therapies of hepatic alveolar echinococcosis: A single-center retrospective case-control study.
    Medicine (Baltimore) 2018 Feb;97(8):e0033
    Department of Liver Surgery, Liver Transplantation Center, West China Hospital of Sichuan University, Chengdu.
    The aim of this study was to evaluate different surgical therapies for hepatic alveolar echinococcosis in different clinical stages.We analyze the clinical data of 115 patients who received surgical treatment in West China Hospital from January 2004 to June 2016. Among these patients, 77 cases underwent radical hepatic resection (group A, n = 77); 17 cases underwent palliative resection (group B, n = 17), and 21 cases underwent liver transplantation (group C, n = 21) with 12 cases of orthotopic liver transplantation and 9 cases of liver autotransplantation. Read More

    Solidification of hydatid cyst fluid with an injectable chitosan/carboxymethylcellulose/β-glycerophosphate hydrogel for effective control of spillage during aspiration of hydatid cysts.
    Prog Biomater 2018 Feb 19. Epub 2018 Feb 19.
    Department of Parasitology and Mycology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
    Cystic echinococcosis (CE)/hydatid cyst is one of the most important helminthic diseases in the world. The treatment of hydatid cyst ranges from surgical intervention to chemotherapy, although the efficacy of chemotherapy is still unclear. Postoperative complication which results from the spillage of cysts during surgical operation is one of the most important concerns in surgical treatment of hydatid cyst. Read More

    The seroprevalence of cystic echinococcosis in a rural normal population, southwestern Iran.
    Infect Disord Drug Targets 2018 02 13. Epub 2018 Feb 13.
    Infectious and Tropical Disease Research Center, Health Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz. Iran.
    Introduction: Cystic echinococcosis is a neglected zoonotic disease with worldwide distribution, which occurs mainly in pastoral regions. Echinococcus granulosus sensu stricto, is the main agent of human infection. Although Iran is an endemic area for CE in the Middle East, lack of data regarding the disease among rural inhabitants of Khuzestan province in recent years, persuaded us to perform the current study. Read More

    Genotype characterization of livestock and human cystic echinococcosis in Mazandaran province, Iran.
    J Helminthol 2018 Feb 15:1-5. Epub 2018 Feb 15.
    Cancer Research Center,Health Research Institute,Babol University of Medical Sciences,BabolI.R. Iran.
    Echinococcus granulosus is a helminth from the family Taeniidae, which causes cystic echinococcosis (CE) in humans and diverse livestock around the world. The identification of existing genotypes in different regions is a major step towards the prevention and establishment of control programmes for the disease. This study aimed to detect CE genotypes using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) of the internal transcribed spacer-1 (ITS1) gene and sequencing of the cytochrome c oxidase subunit 1 (Cox1) gene in isolates from the central part of Mazandaran province, northern Iran. Read More

    [Physiological characteristics of Echinococcus and their association with interventions against echinococcosis].
    Zhonghua Yu Fang Yi Xue Za Zhi 2018 Feb;52(2):210-214
    State Key Laboratory Incubation Base of Xinjiang Major Diseases Research, Clinical Medical Research Institute, the First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China.
    Alveolar and cystic echinococcosis are important zoonotic diseases caused by the dog/fox tapeworms of Echinococcus granulosus and E. multilocularis, which are distributed in almost whole the world. The diseases remarkably impact on the people's health and economic development of communities. Read More

    Albendazole nanocrystals in experimental alveolar echinococcosis: Enhanced chemoprophylactic and clinical efficacy in infected mice.
    Vet Parasitol 2018 Feb 30;251:78-84. Epub 2017 Dec 30.
    Laboratorio de Zoonosis Parasitarias, Instituto de Investigaciones en Producción, Sanidad y Ambiente (IIPROSAM), Facultad de Ciencias Exactas y Naturales. Universidad Nacional de Mar del Plata, Funes 3250, 7600, Mar del Plata, Argentina; Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires, Argentina. Electronic address:
    Human alveolar echinococcosis is caused by the fox tapeworm Echinococcus multilocularis and is usually fatal if left untreated. Medical treatment with albendazole (ABZ) remains an effective option. However, due to its low aqueous solubility, ABZ is poorly and erratically absorbed following oral administration resulting in low drug levels in plasma and liver distribution. Read More

    Knowledge, Awareness and Practices Regarding Cystic Echinococcosis among Livestock Farmers in Basrah Province, Iraq.
    Vet Sci 2018 Feb 6;5(1). Epub 2018 Feb 6.
    Veterinary Public Health and Epidemiology Section, School of Veterinary and Life Sciences, College of Veterinary Medicine, Murdoch University, Perth 6150, Australia.
    Cystic echinococcosis (CE) is an endemic neglected parasitic zoonosis in many of the countries of the Middle East. The disease poses a remarkable economic burden for both animals and humans. In this study, we conducted a questionnaire survey among livestock farmers in Basrah province, southern Iraq, in order to evaluate their knowledge and awareness about CE, and to understand some of the risky practices that could contribute to spread and persistence of such disease. Read More

    Echinococcus multilocularis in a Eurasian lynx (Lynx lynx) in Turkey.
    Parasitology 2018 Feb 7:1-4. Epub 2018 Feb 7.
    Department of Parasitology,Faculty of Veterinary Medicine,Atatürk University,Erzurum,Turkey.
    Echinococcus multilocularis is the causative agent of alveolar echinococcosis (AE), one of the most threatening zoonoses in Eurasia. Human AE is widespread in the Erzurum region of Turkey, but the situation of the disease in intermediate and definitive hosts is unknown. A Eurasian lynx (Lynx lynx) was killed in a traffic accident in the north of Erzurum, and was taken to our laboratory. Read More

    In vivo treatment with IL-17A attenuates hydatid cyst growth and liver fibrogenesis in an experimental model of echinococcosis.
    Acta Trop 2018 May 3;181:6-10. Epub 2018 Feb 3.
    Laboratory of Cellular and Molecular Biology, Department of Biology, University of Sciences and Technology Houari Boumediene. Algiers-Algeria. Electronic address:
    We aimed to assess the effect of exogenous Interleukin (IL)-17A in experimental model of echinococcosis. Swiss mice were inoculated intra-peritoneally with viable protoscoleces (PSCs). Then, IL-17A was administered at 100, 125 or 150 pg/mL two weeks after cystic echinococcosis (CE) induction. Read More

    DNA extraction in Echinococcus granulosus and Taenia spp. eggs in dogs stool samples applying thermal shock.
    Exp Parasitol 2018 Mar 4;186:10-16. Epub 2018 Feb 4.
    Department of Preclinic Sciences, Laboratory of Molecular Immunoparasitology, Center of Translational Medicine, Scientific and Technological Nucleus (CEMT-BIOREN), Universidad de La Frontera, Temuco, Chile; Program of Doctorate in Science, Cellular and Molecular Biology, Universidad de La Frontera, Temuco, Chile. Electronic address:
    The extraction of DNA in taeniid eggs shows complications attached to the composition of stool samples and the high resistance of eggs to degradation. The objective of this study was to test a method of DNA extraction in taeniid eggs by applying a thermal shock to facilitate the chemical-enzymatic degradation of these elements. A group of six tubes containing 1 ml of dog stool sample was spiked with eggs of Echinococcus granulosus and another group of six with Taenia pisiformis. Read More

    The bioinformatics analyses reveal novel antigen epitopes in major outer membrane protein of.
    Indian J Med Microbiol 2017 Oct-Dec;35(4):522-528
    State Key Laboratory Incubation Base of Xinjiang Major Diseases Research (2010DS890294) and Xinjiang Key Laboratory of Echinococcosis, First Affiliated Hospital of Xinjiang Medical University; College of Basic Medicine of Xinjiang Medical University, Urumqi, Xinjiang 830011, P.R. China.
    Purpose: The aim of this study was to predict the T-cell and B-cell epitopes in major outer membrane protein (MOMP) of Chlamydia trachomatis (CT) by using online software and also to analyse the secondary structure of MOMP through bioinformatics tools.

    Materials And Methods: The predictions of secondary structure of MOMP protein were carried out using SOPMA software, and the prediction of B-cell epitopes in MOMP protein was carried out using IEDB and LEPS software, while the T-cell epitopes were predicted by the software of IEBD and SYFPEITHI. The predictions from the software were combined with MOMP protein characteristics, including surface features, hydrophilicity, flexibility, accessibility and plasticity, to analyse the common epitope areas' response by T-cells and B-cells. Read More

    [Pulmonary granuloma in an immunodepressed patient].
    Rev Mal Respir 2018 Jan 12;35(1):74-77. Epub 2018 Feb 12.
    Service de pneumologie de la cavale blanche, EA3878 (GETBO), La-Cavale-Blanche, CHRU de Brest, boulevard Tanguy-Prigent, 29200 Brest, France.
    Introduction: Pulmonary alveolar echinococcosis is a rare but potentially severe condition.

    Case Report: We report the case of a 50-year-old woman suffering from pulmonary alveolar echinococcosis who had had a renal transplant for polycystic liver and kidney disease. A lung opacity was identified radiologically in May 2013. Read More

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