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    Reticulated acanthoma with sebaceous differentiation mimicking melanoma.
    Dermatol Pract Concept 2017 Jul 31;7(3):35-37. Epub 2017 Jul 31.
    Department of Dermatology, Mogi das Cruzes University, Mogi das Cruzes, Brazil.
    Reticulated acanthoma with sebaceous differentiation (RASD) is a rare, benign cutaneous tumor with peculiar histopathologic characteristics [1]. RASD had been described under various synonyms such as superficial epithelioma with sebaceous differentiation, sebocrine adenoma, poroma with sebaceous differentiation, and seborrheic keratosis with sebaceous differentiation [2]. Clinical differential diagnosis of RASD includes cutaneous superficial epithelial neoplasia such as Bowen's disease, superficial basal cell carcinoma (BCC) and intraepidermal eccrine poroma [1]. Read More

    Concomitant poroma and porocarcinoma.
    An Bras Dermatol 2017 Jul-Aug;92(4):550-552
    Faculty of Medicine, Pontificia Universidad Católica de Chile - Santiago, Chile.
    Eccrine poromas and porocarcinomas are adnexal tumors derived from the sweat duct epithelium. However, eccrine poroma is benign in nature, whilst eccrine porocarcinoma is regarded as its malignant counterpart. We report the case of a man who presented simultaneously with an eccrine poroma and eccrine porocarcinoma. Read More

    Eccrine Poroma of the Postauricular Area.
    Arch Craniofac Surg 2017 Mar 25;18(1):44-45. Epub 2017 Mar 25.
    Department of Plastic and Reconstructive Surgery, Dongguk University College of Medicine, Gyeongju, Korea.
    Eccrine poroma is a common benign cutaneous tumor that originates in an intraepidermal eccrine duct. This tumor exhibits acral distribution (sole, palm), and is rarely encountered in the head and neck area. In fact eccrine poroma in the postauricular area has only been rarely reported. Read More

    Primary Cutaneous Mucinous Carcinoma of the Eyelid.
    Arch Craniofac Surg 2016 Sep 23;17(3):176-179. Epub 2016 Sep 23.
    Department of Pathology, Soonchunhyang University Seoul Hospital, Soonchunhyang University College of Medicine, Seoul, Korea.
    Primary cutaneous mucinous carcinoma (PCMC) is a rare low-grade malignant neoplasm derived from the eccrine glands. PCMC most commonly arises in the head and neck, with the eyelid being the most common site of origin. This case report describes a 51-year-old male with a painless, pigmented superficial nodular lesion over his right lower eyelid. Read More

    Primary Cutaneous Mucinous Carcinoma Treated with Narrow Surgical Margin.
    Arch Craniofac Surg 2016 Sep 23;17(3):158-161. Epub 2016 Sep 23.
    Department of Plastic and Reconstructive Surgery, Yonsei University Wonju College of Medicine, Wonju, Korea.
    Primary cutaneous mucinous carcinoma (PCMC) is a rare malignant tumor of eccrine origin. Clinically, the carcinoma presents as a solitary, slow growing, and painless nodule. For this reason, this tumor is often considered to be a benign mass in the preoperative setting. Read More

    Eosinophilic variant of eccrine porocarcinoma of the scalp: Case report and review of the literature.
    Int J Womens Dermatol 2017 Sep 14;3(3):157-160. Epub 2017 Jul 14.
    Department of Dermatology, University of Connecticut School of Medicine, Farmington, CT.
    Porocarcinoma is a rare malignant neoplasm of the acrosyringium with metastatic potential that most commonly presents on the acral skin in older adults (mean age = 72 years). We present the case of a 43-year-old woman who developed a rapidly growing de novo porocarcinoma on the scalp with an unusual oncocytic appearance. The tumor consisted of benign eccrine poroma that arose from the epidermis and broad pushing borders with minimal cytological atypia but ample eosinophilic cytoplasm with numerous mitotic figures. Read More

    Lichen Simplex Chronicus as an Essential Part of the Dermatologic Masquerade.
    Open Access Maced J Med Sci 2017 Jul 24;5(4):556-557. Epub 2017 Jul 24.
    Department of Dermatology, Venereology and Dermatologic Surgery, Medical Institute of Ministry of Interior, and Onkoderma Polyclinic for Dermatology and Dermatologic Surgery, Sofia, Bulgaria.
    A 48 years old female patient had been suffering from the lesions presented for four years. They have started as small, pruritic patches which had been mechanically irritated and grew up in time. The patient had no associated comorbidities or allergies, and she was not under any medication. Read More

    Dermal Substitutes Use in Reconstructive Surgery for Skin Tumors: A Single-Center Experience.
    Int J Surg Oncol 2017 2;2017:9805980. Epub 2017 Jul 2.
    Skin Cancer Department, AC Camargo Cancer Center, São Paulo, SP, Brazil.
    Reconstructive surgery following skin tumor resection can be challenging. Treatment options after removing the tumor are skin grafting, local pedicled and axial flaps, or microsurgery for complex and extensive wounds correction. Recently, the use of dermal substitutes has been extended to reconstructive surgery in cutaneous oncology. Read More

    F-18 FDG PET/CT Imaging of Eccrine Sweat Gland Carcinoma of the Scrotum with Extensive Regional and Distant Metastases.
    Asia Ocean J Nucl Med Biol 2017 ;5(2):104-108
    Department of Nuclear Medicine, Konyang University Hospital, Daejeon, Republic of Korea.
    Eccrine carcinoma is an extremely rare malignant skin cancer arising from eccrine sweat glands with a high metastatic potential. It mainly occurs in the elderly, with equal incidence in both sexes. It usually spreads to regional lymph nodes, with liver, lungs, and bones being the most common sites of distant metastasis. Read More

    Microcystic Adnexal Carcinoma: A Review of the Literature.
    Dermatol Surg 2017 Aug;43(8):1012-1016
    *Division of Dermatology, Department of Internal Medicine, Washington University, St. Louis, Missouri; †Department of Pathology and Immunology, Washington University, St. Louis, Missouri.
    Background: Microcystic adnexal carcinoma (MAC) is a rare, locally aggressive cutaneous neoplasm that commonly occurs on the face.

    Objective: The purpose of this article is to comprehensively review the current literature on MAC pertaining to epidemiology, pathogenesis, clinical presentation, histology, immunohistochemistry, prognosis, follow-up, and treatment.

    Materials And Methods: An extensive literature review was conducted using OVID MEDLINE and PubMed to identify articles relating to MAC. Read More

    Cost-effectiveness of Early Division of the Forehead Flap Pedicle.
    JAMA Facial Plast Surg 2017 Sep;19(5):418-420
    Division of Facial Plastic and Reconstructive Surgery, Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, California.
    Importance: The paramedian forehead flap is considered the gold standard procedure to optimally reconstruct major defects of the nose, but this procedure generally requires 2 stages, where the flap pedicle is divided 3 weeks following the initial surgery to ensure adequate revascularization of the flap from the surrounding recipient tissue bed, which can cost a patient time out of work or away from normal social habits. It has previously been shown that the pedicle may be safely divided after 2 weeks in select patients where revascularization from the recipient bed was confirmed using intraoperative laser fluorescence angiography to potentially save the patient time and money.

    Objective: To demonstrate the cost-effectiveness of takedown of the paramedian forehead flap pedicle after 2 weeks using angiography with indocyanine green (ICG). Read More

    Syringoid Eccrine Carcinoma of the Foot: Report of a Rare Cutaneous Adnexal Neoplasm.
    Int J Surg Pathol 2017 Oct 29;25(7):659-664. Epub 2017 May 29.
    1 Hartford Hospital, Hartford, CT, USA.
    Syringoid eccrine carcinoma is a rare malignant adnexal tumor that typically presents in the head and neck region. Involvement of the extremities is uncommon, with only a few cases reported in the literature. Here, we report our experience with a rare case of syringoid eccrine carcinoma occurring on the plantar surface of the right foot in a 47-year-old African American woman. Read More

    Neuroendocrine differentiation in basal cell carcinoma.
    J Immunoassay Immunochem 2017 26;38(5):487-493. Epub 2017 May 26.
    a Department of Pathology , The La Rabta Hospital, Tunis University , Bab Saadoun, Tunis.
    Basal cell carcinoma (BCC) is the prototypical basaloid tumor of the skin. It may show various patterns simulating other cutaneous tumors due to its pleomorphism. It may have an unusal pattern of differentiation such as squamous, sebaceous, apocrine, eccrine, pilar, and endocrine differentiation. Read More

    Fine needle aspiration cytology of primary cutaneous mucinous carcinoma of axilla-report of a rare case.
    Diagn Cytopathol 2017 Oct 24;45(10):934-938. Epub 2017 May 24.
    Department of Pathology, College of Medicine and Sagore Dutta Hospital, Kalpataru Apartment, Sahid colony, BT road, Sodepur, PO-Khardah, North 24 Parganas, West Bengal, India.
    Primary mucinous eccrine carcinoma is a rare malignant adnexal tumor of older patients. The histopathological features of this tumor are well-established but the cytomorphology of this neoplasm has only been documented in a few cases. The cytology and histology of this tumor may mimic metastatic mucinous carcinoma and may cause a diagnostic dilemma, especially when the tumor is located at axilla. Read More

    Hidroacanthoma simplex: dermoscopy and cryosurgery treatment.
    An Bras Dermatol 2017 Mar-Apr;92(2):253-255
    Department of Dermatology. Hospital do Servidor Público Estadual de São Paulo - São Paulo (SP), Brazil.
    Hidroacanthoma simplex is a rare intraepidermal neoplasia that arises from the acrosyringial portion of the eccrine duct. Malignant transformation of hidroacanthoma simplex is reported in the literature and the treatment is performed with wide excision or Mohs micrographic surgery. We report the first case successfully treated with cryosurgery with a long-term follow up. Read More

    Ductal eccrine carcinoma of the axilla: a diagnostic pitfall.
    An Bras Dermatol 2017 Mar-Apr;92(2):239-242
    Department of Dermatology, Instituto Português de Oncologia de Lisboa - Lisboa, Portugal.
    Ductal eccrine carcinoma (DEC) is a rare sweat gland carcinoma with ductular differentiation. Clinically, it is characterized by a slowly growing, hardened plaque or nodule predominantly located on the head and neck. Histologically, DEC shares similar features to invasive breast carcinoma, thus causing great diagnostic challenges. Read More

    [Hidradenocarcinoma of the heel associated with inguinal metastases].
    Ann Dermatol Venereol 2017 Aug - Sep;144(8-9):536-542. Epub 2017 May 18.
    Service de dermatologie, CHU d'Ibn-Rochd, Casablanca, Maroc.
    Background: Hidradenocarcinoma is a rare malignant tumour involving the sweat glands. It classically arises de novo, only rarely resulting from pre-existing hidradenoma. The literature contains few reports of lymph node metastasis in this tumour. Read More

    Aggressive digital papillary adenocarcinoma: A clinicopathological study of 19 cases.
    J Am Acad Dermatol 2017 Sep 9;77(3):549-558.e1. Epub 2017 May 9.
    Department of Dermatology, Strasbourg University Hospital, Strasbourg, France.
    Background: Aggressive digital papillary adenocarcinomas (ADPA) are malignant tumors of sweat glands having recurrence/metastatic potential.

    Objective: We sought to describe the clinical/histopathological characteristics of a series of ADPA.

    Methods: This is a retrospective case series of 19 ADPA. Read More

    Circulating TNF receptors predict cardiovascular disease in patients with chronic kidney disease.
    Medicine (Baltimore) 2017 May;96(19):e6666
    aDepartment of Internal Medicine, Gyeongsang National University Changwon Hospital, Changwon bDepartment of Internal Medicine, National Medical Center cDepartment of Internal Medicine, Seoul National University College of Medicine dDepartment of Internal Medicine, Seoul National University Boramae Medical Center, Seoul eDepartment of Internal Medicine, Dongguk University Medical Center, Gyeongju fDepartment of Internal Medicine, Dong-A University, Busan gDepartment of Dental Hygiene, College of Health Science, Eulji University, Seongnam hDepartment of Internal Medicine, Yonsei University College of Medicine, Seoul iDepartment of Internal Medicine, Dongguk University Medical Center, Goyang jKidney Research Institute, Seoul National University, Seoul, Republic of Korea.
    Cardiovascular disease (CVD) is the main public health problem in patients with chronic kidney disease (CKD); however, there is no established biomarker for predicting CVD morbidity and mortality in CKD. The aim of this study was to evaluate the role of circulating tumor necrosis factor receptors (cTNFRs) in predicting CVD risk in CKD patients.We prospectively recruited 984 patients with CKD from 11 centers between 2006 and 2012. Read More

    Update on Malignant Sweat Gland Tumors.
    Surg Pathol Clin 2017 Jun 27;10(2):383-397. Epub 2017 Mar 27.
    Department of Pathology, Western General Hospital, Alexander Donald Building, 1st Floor, Crewe Road, Edinburgh EH4 2XU, UK. Electronic address:
    Malignant sweat gland tumors are rare cutaneous neoplasms, traditionally separated according to their behavior into low- and high-grade malignant. There is significant morphologic overlap, and outright malignant tumors may show relatively bland histologic features. They may, therefore, be mistaken easily for benign neoplasms. Read More

    Adnexal Carcinomas Treated With Mohs Micrographic Surgery: A Comprehensive Review.
    Dermatol Surg 2017 Oct;43(10):1199-1207
    Surgical Dermatology Group, Birmingham, Alabama.
    Background: Adnexal carcinomas (ACs) are rare cutaneous malignancies of sweat gland or pilosebaceous origin. Optimal treatment and metastatic potential of AC are poorly defined. Mohs micrographic surgery (MMS) has been increasingly used to treat AC. Read More

    GREM1 is expressed in the cancer-associated myofibroblasts of basal cell carcinomas.
    PLoS One 2017 27;12(3):e0174565. Epub 2017 Mar 27.
    Department of Pathology, Jeju National University School of Medicine and Jeju National University Hospital, Jeju, South Korea.
    Cancer-associated fibroblasts (CAFs) play important roles in cancer progression through their complex interactions with cancer cells. The secreted bone morphogenetic protein antagonist, gremlin1 (GREM1) is expressed by the CAFs of basal cell carcinomas (BCCs), and promotes the growth of cancer cells. In this study, we investigated the expression of GREM1 mRNAs in various benign and malignant skin tumors, including various BCC subtypes. Read More

    SOX10 immunohistochemistry in sweat ductal/glandular neoplasms.
    J Cutan Pathol 2017 Jun 20;44(6):544-547. Epub 2017 Apr 20.
    San Diego Pathologists Medical Group, San Diego, California.
    Background: SOX10 is a newer Schwannian and melanocytic marker that has generated great interest for its relative sensitivity and specificity in the diagnosis of neural crest-derived tumors. Previous studies with SOX10 have shown positive immunohistochemical expression in cutaneous eccrine glands and negative expression in eccrine ducts, apocrine glands and hair follicles. Thus, we hypothesized that some sweat gland tumors of presumed eccrine origin would be positive for SOX10, whereas apocrine-derived sweat gland tumors would not. Read More

    GATA3 and MYB Expression in Cutaneous Adnexal Neoplasms.
    Am J Dermatopathol 2017 Apr;39(4):279-286
    *Departments of Pathology, Porto Medical School and Sao Joao Hospital, Porto, Portugal; †Departments of Pathology, William Beaumont School of Medicine, Royal Oak, MI; ‡Departments of Pathology, Duke University Medical Center, Durham, NC; and §Departments of Pathology, Harvard Medical School and Massachusetts General Hospital, Boston, MA.
    Knowledge of staining pattern of certain immunostains might be useful in the classification of cutaneous adnexal tumors that can have clinical importance. We studied GATA3 and MYB expression in archival materials of 220 adnexal tumors comprised of sebaceous carcinomas, follicular tumors, apocrine carcinoma, predominantly apocrine tumors, predominantly eccrine tumors, and others including adenoid cystic carcinomas. Nuclear GATA3 expression was seen in 70% (153/220) of cases, including sebaceous carcinoma (93%), apocrine carcinoma (93%), follicular neoplasms (100%), and predominantly apocrine neoplasms (69%), yet only 38% of predominantly eccrine neoplasms. Read More

    Primary Cribriform Carcinoma of the Eyelid With Neuroendocrine Features: A Case Report.
    J Drugs Dermatol 2017 Feb;16(2):173-174
    A variety of tumors may involve the eyelid, most of which are primary, but rarely can be metastatic. Previously reported eyelid primary carcinomas with neuroendocrine features include Merkel cell carcinoma, apocrine and eccrine gland carcinoma, sebaceous gland carcinoma, and one report of primary "well-differentiated neuroendocrine tumor." Herein we report the first case of primary cribriform carcinoma of the eyelid with neuroendocrine features. Read More

    [Malignant transformation of an eccrine spiradenoma].
    Ann Dermatol Venereol 2017 Mar 27;144(3):203-207. Epub 2016 Oct 27.
    Service de pathologie, centre hospitalier Lyon sud, 165, chemin du Grand-Revoyet, 69495 Pierre-Bénite, France.
    Introduction: Malignant eccrine spiradenoma is a rare and aggressive tumor, developed on the epithelium of eccrine sweat glands. Typically, it occurs after malignant transformation of benign eccrine spiradenoma, but sometimes it happens de novo.

    Observation: We report a case of malignant eccrine spiradenoma in a 62-year-old woman. Read More

    [A Case of Breast Metastasis of Eccrine Porocarcinoma].
    Gan To Kagaku Ryoho 2016 Nov;43(12):2016-2018
    Dept. of Surgery, Shiga University of Medical Science.
    An 80's woman was diagnosed with eccrine porocarcinoma of the head in 2010.T he tumor was removed surgically but relapsed in the cervical and axillary lymph nodes 2 years later.The patient underwent surgery, and received systemic chemotherapy and radiation. Read More

    Eccrine Porocarcinoma: Patient Characteristics, Clinical and Histopathologic Features, and Treatment in 7 Cases.
    Actas Dermosifiliogr 2017 May 19;108(4):e27-e32. Epub 2017 Jan 19.
    Servicio de Dermatología Médico-Quirúrgica y Venereología, Hospital Universitario Príncipe de Asturias, Universidad de Alcalá, Alcalá de Henares, Madrid, España.
    Eccrine porocarcinoma is a rare, malignant cutaneous adnexal tumor that arises from the ducts of sweat glands. Found mainly in patients of advanced age, this tumor has diverse clinical presentations. Histology confirms the diagnosis, detects features relevant to prognosis, and guides treatment. Read More

    Squamoid eccrine ductal carcinoma.
    An Bras Dermatol 2016 Nov-Dec;91(6):799-802
    Universidade de São Paulo (USP) - São Paulo (SP), Brazil.
    Squamoid eccrine ductal carcinoma is an eccrine carcinoma subtype, and only twelve cases have been reported until now. It is a rare tumor and its histopathological diagnosis is difficult. Almost half of patients are misdiagnosed as squamous cell carcinoma by the incisional biopsy. Read More

    MYB, CD117 and SOX-10 expression in cutaneous adnexal tumors.
    J Cutan Pathol 2017 May 14;44(5):444-450. Epub 2017 Feb 14.
    Departments of Dermatology and Pathology, University of California, San Francisco, California.
    Background: Elevated MYB expression has been documented in adenoid cystic carcinoma (ACC), cylindroma, and spiradenoma, but the specificity of this finding is unknown. CD117 and SOX-10 expression also occurs in some cutaneous adnexal tumors. This study assesses MYB, CD117 and SOX-10 expression in cutaneous adnexal tumors. Read More

    Distinct expression profile of stem cell markers, LGR5 and LGR6, in basaloid skin tumors.
    Virchows Arch 2017 Mar 9;470(3):301-310. Epub 2017 Jan 9.
    Department of Pathology, Seoul National University College of Medicine, 28 Yeongeon-dong, Seoul, 110-799, South Korea.
    Mammalian epidermis, which is composed of hair follicles, sebaceous glands, and interfollicular epidermis, is maintained by discrete stem cells. In vivo lineage tracing demonstrated that murine LGR5 cells are mainly responsible for hair follicle regeneration whereas LGR6 cells generate sebaceous glands and interfollicular epidermis. However, little is known about their expression in the human skin tumors. Read More

    Incidence and Clinical Features of Rare Cutaneous Malignancies in Olmsted County, Minnesota, 2000 to 2010.
    Dermatol Surg 2017 Jan;43(1):116-124
    *Department of Dermatology, Mayo Clinic, Rochester, Minnesota;†Division of Biomedical Statistics and Informatics, Mayo Clinic Rochester, Minnesota;‡Division of Dermatologic Surgery, Mayo Clinic, Rochester, Minnesota.
    Background: The incidence of rare cutaneous malignancies is unknown. Current estimates of rare cutaneous malignancy incidences are based on broad epidemiologic data or single institution experiences, not population-based data.

    Objective: To determine the incidence of several rare nonmelanoma skin cancers. Read More

    Coexistence of Adult Onset Eruptive Syringoma and Bilateral Renal Cell Carcinoma: A Case Report.
    Am J Dermatopathol 2017 Jan;39(1):56-58
    Departments of *Dermatology, and †Department of Pathology, Ankara Numune Training and Research Hospital, Ankara,Turkey.
    Eruptive syringoma is an unusual variant of syringoma, which usually presents before or during puberty. It typically occurs in large numbers as multiple yellow-brown-colored papules, which may show spontaneous regression. Because some authors have proposed that it could present as a reactive process of eccrine ducts to an inflammatory reaction caused by an unknown trigger, the exact pathomechanism is still unclear. Read More

    Eccrine porocarcinoma of the vulva: a case report and review of the literature.
    J Med Case Rep 2016 Nov 10;10(1):319. Epub 2016 Nov 10.
    Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, 1-1, Seiryo, Aoba, Sendai, 980-8574, Japan.
    Background: Malignant tumors arising from the vulva account for only 0.6 % of all cancers in female patients. The predominant histologic type, representing about 90 % of these malignancies, is squamous cell carcinoma. Read More

    In situ carcinoma in a hybrid cyst: a case report.
    J Cutan Pathol 2017 Feb 1;44(2):189-192. Epub 2016 Dec 1.
    Dr. Lütfi Kırdar Kartal Education and Research Hospital, Department of Dermatology, Istanbul, Turkey.
    Follicular hybrid cysts including two or more components of the epithelial skin adnexa are very rare. The epithelial lining of hybrid cysts varies, and either contains epidermis, and trichilemmal squamous epithelium, or other epithelia of the skin adnexa. Hybrid cysts may also be associated with neoplasia, such as in situ carcinoma, Bowen's disease and squamous cell carcinoma. Read More

    The role of DOG1 immunohistochemistry in dermatopathology.
    J Cutan Pathol 2016 Nov 5;43(11):974-983. Epub 2016 Sep 5.
    Department of Diagnostic Pathology, Kainan Hospital, Yatomi, Japan.
    Background: This study was designed to evaluate the immunoexpression of DOG1, a specific marker expressed in gastrointestinal stromal tumors, in normal skin tissues and cutaneous epithelial tumors.

    Methods: DOG1 immunostaining extent, intensity and pattern were evaluated in 69 cutaneous apocrine/eccrine tumors, 11 sebaceous tumors, 46 follicular tumors, 52 keratinocytic tumors and perilesional normal tissues.

    Results: In normal tissues, DOG1 was expressed strongly in the intercellular canaliculi of eccrine glands, moderately in the myoepithelial cells of mammary and anogenital mammary-like glands, and weakly or not at all in the periphery of sebaceous lobules and the lower layer of epidermis and follicular infundibulum. Read More

    Depth and Patterns of Adnexal Involvement in Primary Extramammary (Anogenital) Paget Disease: A Study of 178 Lesions From 146 Patients.
    Am J Dermatopathol 2016 Nov;38(11):802-808
    *Department of Pathology, Clinical Research and Practical Center for Specialized Oncological Care, Saint-Petersburg, Russia; †Department of Pathology, Medical Faculty, Saint-Petersburg State University, Russia; ‡Department of Pathology, Petrov's Research Institute of Oncology, Saint Petersburg, Russia; §PathWest Laboratory Medicine WA, King Edward Memorial Hospital, Perth, Western Australia, Australia; ¶PathWest Laboratory Medicine WA, QEII Medical Centre, Nedlands, WA, Australia; ‖University of Western Australia, School of Pathology and Laboratory Medicine, Nedlands, WA, Australia; **Dermatopathologische Gemeinschaftspraxis, Friedrichshafen, Germany; ††Sikl's Department of Pathology, Medical Faculty in Pilsen, Charles University in Prague, Pilsen, Czech Republic; ‡‡Bioptical Laboratory, Pilsen, Czech Republic; §§Miraca Life Science, Irving, TX; ¶¶Department of Pathology, Division of Dermatopathology, Medical College of Wisconsin, Milwaukee, WI; ‖‖Department of Obstetrics and Gynecology, Charles University Medical Faculty Hospital, Pilsen, Czech Republic; ***Department of Pathology, Regional Hospital, Most, Czech Republic; and †††Dermatopathology Unit, Department of Dermatology, Zurich University Hospital, Zurich, Switzerland.
    Extramammary Paget disease (EMPD) is a rare neoplasm usually presenting in the anogenital area, most commonly in the vulva. Adnexal involvement in primary EMPD is a very common feature and serves as a pathway for carcinoma to spread into deeper tissue. The depth of carcinomatous spread along the appendages and the patterns of adnexal involvement were studied in 178 lesions from 146 patients with primary EMPD. Read More

    Reexcision Perineural Invasion and Epithelial Sheath Neuroma Possibly on a Spectrum of Postinjury Reactive Hyperplasia Mediated by IL-6.
    Am J Dermatopathol 2017 Jan;39(1):49-52
    *Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY; †Ohio State University Comprehensive Cancer Center, Columbus, OH; and ‡NYC Dermatology and Cosmetic Center, New York, NY.
    Epithelial sheath neuroma is a rarely recognized but established entity in the medical literature. First described in 2000 by Requena et al, there have only been 7 published cases to date, mostly in female patients and presenting as symptomatic solitary lesions on the back without a known history of trauma. In 2006, Beer et al described and reviewed a dozen cases in which epithelial sheath neuroma-like features were seen in the advent of a surgical procedure, which was termed "re-excision perineural invasion" and attributed to possible eccrine duct implantation during surgery. Read More

    Giant metastasizing malignant hidradenoma in a child.
    Indian Dermatol Online J 2016 Sep-Oct;7(5):410-413
    Department of Pathology, National Institute of Pathology, Indian Council of Medical Research Laboratory, Safdarjung Hospital Campus, New Delhi, India.
    An 8-year-old girl presented with a scalp swelling. The swelling was recurrent, reappearing everytime after local excision. She underwent surgery and the histopathologic diagnosis was malignant hidradenoma. Read More

    Pigmented eccrine poroma: dermoscopic and confocal features.
    Dermatol Pract Concept 2016 Jul 31;6(3):59-62. Epub 2016 Jul 31.
    Dermatology and Skin Cancer Unit, Arcispedale S. Maria Nuova, IRCCS, Reggio Emilia, Italy.
    Eccrine poroma is a rare benign adnexal tumor of epithelial cells originating from the terminal ductal portion of the sweat glands that is typically located on palms and soles, although other cutaneous sites can be affected [1]. It is usually nonpigmented even if there is a pigmented variant that corresponds to 17% of cases and it is usually underdiagnosed, since it is mistakenly confused with other pigmented tumors [2,3]. Dermoscopy and reflectance confocal microscopy (RCM) may assist in the correct diagnosis of this tumor. Read More

    Pigmented hidrocystoma of nasal epithelium (PHONE): report of a man with a pigmented hidrocystoma of his nose and literature review.
    Dermatol Online J 2016 May 15;22(5). Epub 2016 May 15.
    Department of Dermatology, University of California San Diego, San Diego, CA.
    Background: Hidrocystomas are benign tumors of apocrine or eccrine epithelium. They most commonly occur on the head and neck, especially periorbitally. Albeit rare, these adnexal tumors may present as pigmented lesions. Read More

    Eccrine Porocarcinoma Presenting as a Hand Cyst.
    J Hand Surg Am 2016 Nov 1;41(11):e425-e427. Epub 2016 Sep 1.
    Department of General Surgery, Jewish Hospital-Mercy Hospital, Cincinnati, OH.
    Eccrine porocarcinoma is a rare tumor that arises from the epithelium of the eccrine ducts, with a tendency for metastatic spread and a high rate of local recurrence after excision. It was first described in 1963 by Pinkus and Mehregan and can present clinically as a nodule, erosive plaque or a polypoid growth that may ulcerate. The variable clinical appearance of these lesions can make diagnosis challenging and could delay appropriate treatment. Read More

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