1,079 results match your criteria Eccrine Carcinoma


GATA3-Positive Adnexal Adenocarcinoma: Report of a Confusing Case with a Potential Pitfall of Leading to a Misdiagnosis of Urothelial Carcinoma and a Review of Published Work.

Ann Dermatol 2020 Oct 29;32(5):417-421. Epub 2020 Sep 29.

Department of Dermatology, Kansai Medical University Medical Center, Osaka, Japan.

We describe a confusing case of GATA3-positive adnexal adenocarcinoma with a potential pitfall of leading to a misdiagnosis of urothelial carcinoma. A 62-year-old male presented with a subcutaneous nodule on the right lower abdomen around a scar from surgery for urothelial carcinoma in the right urinary tract, which had been resected 8 years previously. Histologically, atypical cells possessing ample cytoplasm and partial intracytoplasmic lumens were densely grouped in the subcutaneous expansive nodule and bilateral inguinal lymph nodes dissected. Read More

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October 2020

Eccrine Porocarcinoma: A Multicenter Retrospective Study with Review of the Literatures Reported in Korea.

Ann Dermatol 2020 Jun 24;32(3):223-229. Epub 2020 Apr 24.

Department of Dermatology, College of Medicine, Korea University, Seoul, Korea.

Background: Eccrine porocarcinoma (EPC) is a rare malignant cutaneous adnexal tumor. Other than several scattered case reports, no comprehensive review on EPC has been conducted in Korea.

Objective: To clinicopathologically review all EPC cases from our institutions as well as those reported in Korea. Read More

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Mohs Surgery Outside Usual Indications: A Review.

Acta Dermatovenerol Croat 2020 Dec;28(7):210-214

Pedro Rodríguez-Jiménez, MD, Dermatology Department, Hospital Universitario de la Princesa, Madrid, Calle Diego de Leon 62, 28006 Madrid, Spain;

The body of literature supporting the use of Mohs micrographic surgery (MMS) in tumors outside the main indications (basal cell carcinoma, squamous cell carcinoma, dermatofibrosacroma protuberans, lentigo maligna) is constantly growing, but it is still based on case reports, case series, or at best institutional case series that focus on a single malignancy. Our aim in this review was to assess use of MMS in an array of rare tumors outside the usual indications. A review was performed using the MEDLINE database and the search engine ClinicalKey®. Read More

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December 2020

NUT Is a Specific Immunohistochemical Marker for the Diagnosis of YAP1-NUTM1-rearranged Cutaneous Poroid Neoplasms.

Am J Surg Pathol 2021 Feb 24. Epub 2021 Feb 24.

*CARADERM, French Network of Rare Cutaneous Cancer †Department of Pathology, Timone University Hospital ‡Aix Marseille University, INSERM, MMG, Marseille §Department of Pathology, Trousseau University Hospital, Tours ∥Department of Pathology, Cochin Hospital, AP-HP Paris University Center ¶University of Paris #Molecular Oncology Unit ∥∥Department of Pathology, Hospital Saint-Louis, AP-HP **INSERM, U976 HIPI, Paris ††Department of Dermatology, Lyon-Sud Hospital ‡‡Department of Biopathology, Léon Bérard Centre, Cypath, Lyon §§Department of Pathology, Bordeaux University Hospitals, Pessac ¶¶Department of Pathology, University Hospital of Poitiers ##LITEC EA 4331, B36, Poitiers, France.

YAP1-NUTM1 fusion transcripts have been recently reported in poroma and porocarcinoma. NUTM1 translocation can be screened by nuclear protein in testis (NUT) immunohistochemistry in various malignancies, but its diagnostic performance has not been thoroughly validated on a large cohort of cutaneous epithelial neoplasms. We have evaluated NUT immunohistochemical expression in a large cohort encompassing 835 cases of various cutaneous epidermal or adnexal epithelial neoplasms. Read More

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February 2021

A case of eccrine porocarcinoma: A treacherous mimic and diagnostic challenge.

Indian J Pathol Microbiol 2021 Jan-Mar;64(1):186-188

Dermatology, Calcutta National Medical College, Siliguri, West Bengal, India.

Eccrine porocarcinoma is a rare malignant dermal appendageal tumor notorious for its varied morphology, both clinically and histologically; and it can pose a considerable diagnostic dilemma to both the dermatologist and the pathologist. Herein, we present a case of a 74-year-old woman with slow-growing nodular masses on both buttocks, reaching a fairly large size over a course of 3 years. Although atypical morphologic features posed significant diagnostic difficulty to both the surgeon and the pathologists, it was eventually diagnosed as eccrine porocarcinoma with focal squamoid features, using immunostains. Read More

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January 2021

Treatment of Recurrent Primary Cutaneous Mucinous Carcinoma of the Eyelid with Modified Wide Local Excision.

Case Rep Ophthalmol Med 2020 18;2020:6668640. Epub 2020 Dec 18.

Department of Ophthalmology, University of Florida, Gainesville, FL, USA.

Primary cutaneous mucinous carcinoma (PCMC) is a rare, low-grade malignant neoplasm of the sweat gland, whose history has been controversial regarding eccrine versus apocrine origin. This case report describes a 53-year-old male who presented to the University of Florida, Gainesville, ophthalmology clinic and was referred to the oculoplastics service with a painless, subcentimeter mass on the lateral right upper eyelid including the canthus, consistent with recurrent primary cutaneous mucinous carcinoma of the eyelid. Four years prior, the patient had undergone excisional biopsy of the lesion in a clinic, which revealed residual tumor, but the patient deferred further surgery at the time. Read More

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December 2020

Syringomatous adenoma of the nipple with microcalcifications on mammography: A case report.

Breast J 2021 Feb 25;27(2):170-172. Epub 2020 Dec 25.

Department of Surgery, University of Massachusetts Medical School-Baystate, Springfield, MA, USA.

Syringomatous adenoma of the nipple (SAN) is a rare benign lesion which often presents as a subareolar mass with associated nipple shape changes including pruritus, crusting, and discharge It is thought that syringomatous tumors arise from eccrine glands of the nipple and areola. Due to its locally infiltrative growth pattern the main differential is with low-grade adenosquamous carcinoma which requires more aggressive surgical treatment. Syringomatous adenoma of the nipple can recur, and therefore complete local excision is recommended. Read More

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February 2021

A Case Report of Malignant Eccrine Porocarcinoma Involving the Palm Requiring Surgical Excision and Free Flap Reconstruction.

Am J Case Rep 2020 Nov 26;21:e925231. Epub 2020 Nov 26.

Department of General Surgery, University of Illinois at Chicago, Chicago, IL, USA.

BACKGROUND Eccrine porocarcinoma (EPC) was first described in 1963 as an epidermotropic eccrine carcinoma. Fifty years later, its etiology remains poorly understood. The infrequent nature of this disease merits further inquiry into its etiology, presentation, and standards of management. Read More

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November 2020

Utility of YAP1 and NUT immunohistochemistry in the diagnosis of porocarcinoma.

J Cutan Pathol 2021 Mar 14;48(3):403-410. Epub 2020 Dec 14.

Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.

Background: Porocarcinoma is the malignant counterpart of poroma, a benign tumor derived from the eccrine or apocrine units. In contrast to poroma, porocarcinoma is rare and its diagnosis may be challenging. Recent work has identified YAP1-associated gene fusions in most poromas, and a subset of porocarcinomas. Read More

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Eccrine porocarcinoma: case report and review of the literature.

G Ital Dermatol Venereol 2020 Aug;155(4):500-504

Division of Plastic Surgery, Department of Surgical Sciences, University of Parma, Parma, Italy.

Eccrine porocarcinoma is a rare skin cancer that originates from the acrosyringium of eccrine sweat glands. From the clinical point of view the differential diagnosis with other skin cancers such as basal cell carcinoma and squamous cell carcinoma it is often impossible, only the histopathologic features can lead to the definitive diagnosis. Eccrine porocarcinoma can arise from a previous poroma or de novo, it may recur after surgical excision and cause lymph node and visceral metastasis. Read More

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Primary adenocarcinomas of the vulva and related structures: An enigmatic and diverse group of tumors.

Semin Diagn Pathol 2021 Jan 25;38(1):71-84. Epub 2020 Sep 25.

Department of Pathology, Anatomic Pathology Division, University of California San Diego Health, La Jolla, CA.

Approximately half of adenocarcinomas that involve the vulva are secondary, either through direct extension or metastases from elsewhere. Primary vulvar adenocarcinomas are rare and encompass a diverse array of neoplasms that are nominally classified based on the presumed tissue or organ of origin, the tumoral phenotype, or both. In this review, we summarize the clinicopathologic features of adenocarcinomas that originate from the vulva and related structures, including the terminal urethra. Read More

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January 2021

Sclerosing Signet Ring Cell Carcinoma of the Lacrimal Gland: A Potentially New Primary Entity.

Ocul Oncol Pathol 2020 Aug 7;6(4):265-274. Epub 2020 Feb 7.

David G. Cogan Laboratory of Ophthalmic Pathology, Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts, USA.

An 88-year-old man presented with diplopia, limitation of extraocular movements, and a firm palpable mass in the superolateral orbit. Biopsy revealed a sclerosing signet ring cell carcinoma with histopathologic features mimicking those of a primary signet ring cell (histiocytoid) carcinoma of the eyelid of eccrine or apocrine gland origin, a metastasis from an invasive lobular breast carcinoma or a metastatic diffuse-type gastric carcinoma. An extensive panel of immunohistochemical stains and molecular genetic analyses unequivocally failed to establish a precise diagnosis. Read More

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Surgical management and lymph-node biopsy of rare malignant cutaneous adnexal carcinomas: a population-based analysis of 7591 patients.

Arch Dermatol Res 2020 Sep 23. Epub 2020 Sep 23.

Department of Dermatology, University of Minnesota, 516 Delaware St SE, Minneapolis, MN, 55401, USA.

Objective: To analyze the prognosis of cutaneous adnexal malignancies, survival relative to surgical management, and utility of lymph-node biopsy.

Design: Population-based study of the SEER-18 database from 1975 to 2016.

Participants: 7591 patients with sweat gland carcinoma, hidradenocarcinoma, spiradenocarcinoma, sclerosing sweat duct tumor/microcystic adnexal tumor (SSDT/MAC), porocarcinoma, eccrine adenocarcinoma, and sebaceous carcinoma RESULTS: Five-year OS ranged from 68. Read More

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September 2020

Eccrine Porocarcinoma: Avoiding Diagnostic Delay.

Foot Ankle Spec 2020 Oct 17;13(5):415-419. Epub 2020 Aug 17.

Department of Internal Medicine, Division of Metabolism, Endocrinology, and Diabetes, University of Michigan Health System, Ann Arbor, Michigan.

Skin cancer is the most common cancer within the United States. Reports estimate that 1 in 5 Americans will develop some form of skin cancer. Eccrine porocarcinoma is a rare type of skin cancer of sweat gland origin. Read More

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October 2020

Atypical Non-neoplastic Changes in Anogenital Mammary-like Glands Accompanying Invasive Squamous Cell Carcinoma.

Int J Gynecol Pathol 2021 Mar;40(2):180-184

Long regarded as ectopic or supernumerary breast tissue, anogenital mammary-like glands (AGMLG) are now considered a normal constituent of the anogenital area. AGMLG are presumed to be the origin for various benign and malignant lesions. Changes in AGMLG compatible with usual ductal hyperplasia and atypical ductal hyperplasia considered as precursor lesions and its presence in specimens can be explained by their role in the pathogenesis of primary extramammary Paget disease. Read More

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Analysis of Head and Neck Primary Cutaneous Mucinous Carcinoma: An Indolent Tumor of the Eccrine Sweat Glands.

J Craniofac Surg 2020 Sep 1. Epub 2020 Sep 1.

Department of Otolaryngology, Rutgers New Jersey Medical School, Newark, NJ.

Background/objectives: Primary cutaneous mucinous carcinoma (PCMC) of the head and neck is a rare pathologic entity that is an adenocarcinoma of the eccrine sweat glands. Though it has low metastatic potential, it does have a significant recurrence rate. Due to its rarity, its clinical features are not well-known. Read More

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September 2020

Mucinous eccrine carcinoma of the eyelid: A case report study.

Caspian J Intern Med 2020 May;11(3):337-339

Department of Pathology, School of Medicene, Kermanshah University of Medical Sciences, Kermanshah, Iran.

Background: Primary mucinous eccrine carcinoma (PMEC) is a quite rare malignant tumor that typically involves the head and neck region in approximately 75% of patients and the periorbital area is the most common area.

Case Presentation: A 57-year-old man was seen with a painless red mass involving the left lower eyelid for the past 7 months. Examination revealed a small mass measuring 0. Read More

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Clear cell papillary neoplasm of the breast with MAML2 gene rearrangement: Clear cell hidradenoma or low-grade mucoepidermoid carcinoma?

Pathol Res Pract 2020 Oct 2;216(10):153140. Epub 2020 Aug 2.

Department of Pathology, University of Alabama at Birminham, Birmingham, AL, United States. Electronic address:

Clear cell hidradenoma (CCH) is an uncommon adnexal tumor usually arising from eccrine glands and commonly seen on the face and the upper extremities. CCH occurring in the breast is extremely rare. Herein we report a case of MAML2-rearranged CCH of breast with a papillary architecture closely mimicking intraductal papilloma, adenomyoepithelioma and low-grade mucoepidermoid carcinoma, thus representing a source of diagnostic confusion. Read More

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October 2020

NECTIN4 Expression in Extramammary Paget's Disease: Implication of a New Therapeutic Target.

Int J Mol Sci 2020 Aug 16;21(16). Epub 2020 Aug 16.

Department of Dermatology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan.

Extramammary Paget's disease (EMPD) is a rare skin cancer arising in the anogenital area. Most EMPD tumors remain dormant as in situ lesions, but the outcomes of patients with metastatic EMPD are poor because of the lack of effective systemic therapies. Nectin cell adhesion molecule 4 (NECTIN4) has attracted attention as a potential therapeutic target for some cancers. Read More

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[Eccrine porocarcinoma of the nose with cervical metastasis:a case report].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2020 Jul;34(7):657-659

An 18-year-old man presented with a slow-growing, painful mass on the nasal dorsum that first appeared 4 years earlier. Clinical examination revealed a 5 cm×6 cm, claret-coloured, firm, nonmobile mass on the dorsum of the nose with superficial ulceration and purulent discharge. After several operations, radiotherapy and chemotherapy, no nasal recurrence was found, but recurrence of metastatic masses in the neck. Read More

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Eyelid Eccrine Poroma: A Case Report and Review of Literature.

Cureus 2020 Jun 29;12(6):e8906. Epub 2020 Jun 29.

Ophthalmology, 12 De Octubre Hospital, Complutense University, Madrid, ESP.

Poroma is a rare benign tumor of the epidermal sweat duct unit with predilection for the head and neck. Only six cases with eyelid location have been described in the literature (PubMed). A 34-year-old male presented with a single tumor on the left upper eyelid. Read More

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Basal Cell Carcinoma and Eccrine Porocarcinoma of the Eyelid.

Ophthalmic Plast Reconstr Surg 2021 Mar-Apr 01;37(2):e53-e56

Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida.

An 81-year-old woman presented with a progressively enlarging indurated, firm lesion encompassing one-third of the left upper eyelid. Four years prior, a similar lesion at that same site had been excised and diagnosed as a basal cell carcinoma. The patient underwent a full-thickness excision of the lesion with frozen section, cryotherapy, and reconstruction. Read More

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Engrailed Homeobox 1 and Cytokeratin 19 Are Independent Diagnostic Markers of Eccrine Porocarcinoma and Distinguish It From Squamous Cell Carcinoma.

Am J Clin Pathol 2020 09;154(4):499-509

Department of Human Pathology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.

Objectives: The diagnostic utility of En1 in the histopathologic differentiation of eccrine porocarcinoma (EPC) from invasive squamous cell carcinoma (SCC) was investigated.

Methods: Expression of En1 and CK19 in 16 cases of EPC was immunohistochemically examined and compared with that in 32 cases of SCC.

Results: In all 16 EPCs, En1 was expressed in 3% to 100% of tumor cells. Read More

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September 2020

YAP1-MAML2-Rearranged Poroid Squamous Cell Carcinoma (Squamoid Porocarcinoma) Presenting as a Primary Parotid Gland Tumor.

Head Neck Pathol 2021 Mar 5;15(1):361-367. Epub 2020 Jun 5.

Department of Otorhinolaryngology, Head and Neck Surgery, Bundeswehrkrankenhaus, Berlin, Germany.

Porocarcinoma (synonym: malignant eccrine poroma) is a rare aggressive carcinoma type with terminal sweat gland duct differentiation. The squamous variant of porocarcinoma is even less frequent and might be indistinguishable from conventional squamous cell carcinoma (SCC). We herein describe the first case of a carcinoma presenting as a primary parotid gland malignancy in a 24-year-old male without any other primary tumor. Read More

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[Eccrine carcinoma: a diagnostic pitfall].

Ned Tijdschr Geneeskd 2020 03 19;164. Epub 2020 Mar 19.

Ziekenhuis Gelderse Vallei, afd. Chirurgie, Ede.

Background: The eccrine carcinoma is a rare form of skin adnexal malignancy, usually presenting as a locally invasive, solitary lesion in the head and neck region. Histopathologically and immunohistochemically, eccrine carcinomas are difficult to differentiate from cutaneous metastases of breast carcinomas. Unlike treatment of cutaneous metastasis, treatment of a solitary eccrine carcinoma entails excision, generally without systematic therapy. Read More

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Are clinicians successful in diagnosing cutaneous adnexal tumors? a retrospective, clinicopathological study

Turk J Med Sci 2020 06 23;50(4):832-843. Epub 2020 Jun 23.

Department of Dermatology, Göztepe Training and Research Hospital, İstanbul Medeniyet University, İstanbul, Turkey

Background/aim: Cutaneous adnexal tumors (CAT) are rare tumors originating from the adnexal epithelial parts of the skin. Due to its clinical and histopathological characteristics comparable with other diseases, clinicians and pathologists experience difficulties in its diagnosis.We aimed to reveal the clinical and histopathological characteristics of the retrospectively screened cases and to compare the prediagnoses and histopathological diagnoses of clinicians. Read More

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Eccrine Porocarcinoma with Zosteriform Metastasis.

Cureus 2020 Feb 4;12(2):e6873. Epub 2020 Feb 4.

Surgery, South Colombian University, Neiva, COL.

Eccrine porocarcinoma is a rare malignant tumor that develops in the eccrine glands, appearing as a primary tumor, or by malignant transformation of an eccrine poroma. It is a carcinoma with high metastatic and recurrent potential; it has the same incidence in both sexes, and mainly affects the elderly. Its diagnosis, rather than clinical, is histological, and due to the rarity of the disease, it is a pathological challenge. Read More

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February 2020

Central Nervous System-Invading Eccrine Gland Carcinoma: A Clinicopathologic Case Series and Literature Review.

World Neurosurg 2020 06 3;138:e17-e25. Epub 2020 Mar 3.

Computational Neurosciences Outcomes Center, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA; Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

Background: Eccrine carcinoma involvement of the central nervous system (CNS) is exceedingly rare. The prognosis and response to treatment of this pathology remain poorly characterized.

Methods: A retrospective case series and literature review were conducted. Read More

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Poroid Hidradenocarcinoma of the Ankle: Case Report of a Rare Malignant Cutaneous Adnexal Neoplasm.

J Foot Ankle Surg 2020 Mar - Apr;59(2):423-426

Professor, Department of Orthopaedic Surgery, The Johns Hopkins University, Baltimore, MD. Electronic address:

Soft-tissue masses on the anterior ankle result from a broad range of underlying processes, often presenting a diagnostic challenge. Appropriate treatment of these tumors can be determined by using a combination of patient history, interpretation of pathologic findings, physical examination, and radiographic appearance. We present a case of an exceptionally rare malignant cutaneous adnexal tumor, highlighting the importance of adherence to fundamental biopsy principles for diagnosing and managing musculoskeletal lesions. Read More

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January 2021