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    Flushing Disorders Associated with Gastrointestinal Symptoms: Part 1, Neuroendocrine Tumors, Mast Cell Disorders and Hyperbasophila.
    Clin Med Res 2018 Apr 12. Epub 2018 Apr 12.
    University of Central Florida College of Medicine/HCA Consortium Graduate Medical Education, North Florida Regional Medical Center, 6500 W Newberry Rd, Gainesville, FL 32605
    Flushing is the subjective sensation of warmth accompanied by visible cutaneous erythema occurring throughout the body with a predilection for the face, neck, pinnae, and upper trunk where the skin is thinnest and cutaneous vessels are superficially located and in greatest numbers. Flushing can be present in either a wet or dry form depending upon whether neural-mediated mechanisms are involved. Activation of the sympathetic nervous system results in wet flushing, accompanied by diaphoresis, due to concomitant stimulation of eccrine sweat glands. Read More

    Primary mucinous carcinoma of skin with a trichoadenomatous component: A rare case report.
    Indian J Dermatol Venereol Leprol 2018 Apr 4. Epub 2018 Apr 4.
    Leelavathi Advanced Skin and Laser Centre, Guntur, Andhra Pradesh, India.
    Primary mucinous carcinoma of the skin is a rare subtype of eccrine sweat gland tumors. Differentiating it from metastatic adenocarcinomas is important in the management of this condition. We report the case of a 55-year-old female presenting with a painless nodule, which was subsequently diagnosed as primary mucinous carcinoma of skin with a trichoadenomatous component. Read More

    Microcystic adnexal carcinoma-diagnostic criteria and therapeutic methods: case report and review of the literature.
    Int J Oral Maxillofac Surg 2018 Mar 27. Epub 2018 Mar 27.
    Department of Maxillofacial Surgery, University Hospital Dubrava, Zagreb, Croatia. Electronic address:
    Microcystic adnexal carcinoma (MAC) is a rare, infiltrating, locally aggressive cutaneous neoplasm of combined follicular and eccrine/apocrine histogenesis, usually presenting on the upper lip or face. Differentiation from other adnexal tumours is very important because the clinical management of these tumours is radically different, and misdiagnosis may lead to incorrect treatment. A case of recurrent MAC in the upper lip, treated with multiple excisions and postoperative radiation therapy (PORT), is presented herein. Read More

    Nodular Cystic Basal Cell Carcinoma of the Trunk: a Diagnostic Dilemma in an Unsuspecting Youth.
    Iran J Pathol 2017 1;12(4):410-412. Epub 2017 Oct 1.
    Department of Skin and venereal diseases, Dayanand Medical College and Hospital, Ludhiana, India.
    Basal cell carcinoma (BCC) commonly affects the elderly and is mostly confined to the head and neck region. Only 10% of all cases occur on the trunk. We presented a case of bullous lesion on the abdomen in a young male, initially diagnosed by clinicians as a vascular nevus. Read More

    A Case of a Malignant Cutaneous Mixed Tumor (Chondroid Syringoma) of the Scapula Treated With Staged Margin-Controlled Excision.
    Am J Dermatopathol 2018 Mar 6. Epub 2018 Mar 6.
    Pathology, University of Massachusetts Medical School, Worcester, MA.
    Cutaneous mixed tumor (chondroid syringoma) is the cutaneous counterpart of pleomorphic adenoma of salivary glands, comprised of both epithelial and mesenchymal components. Malignant transformation is exceptionally rare, with only a few cases reported. We report a case of a malignant cutaneous mixed tumor in an 86-year-old white man who presented with a pink indurated plaque on his left scapula. Read More

    Polymorphous Sweat Gland Carcinoma: An Immunohistochemical and Molecular Study.
    Am J Dermatopathol 2018 Mar 6. Epub 2018 Mar 6.
    Department of Pathology, Medical College of Wisconsin, Milwaukee, WI.
    Polymorphous sweat gland carcinoma is an uncommon low-grade malignant adnexal tumor with a marked predilection for the distal extremities. Histologically, the lesions are characterized by a cellular proliferation showing a combination of growth patterns, including trabecular, solid, tubular, cribriform, or adenoid cystic and pseudopapillary. The immunohistochemical and molecular profile of these tumors has not yet been properly addressed. Read More

    Once in a Blue Moon … Rare Adnexal Tumor: From the Clinical and Videodermoscopical Aspects to the Mohs Surgery and the Histological Diagnosis.
    Open Access Maced J Med Sci 2018 Jan 21;6(1):146-148. Epub 2018 Jan 21.
    University G. Marconi of Rome, Dermatology and Venereology, Rome, Italy.
    The adnexal tumours are a very heterogeneous group of lesions, more and more studied in the literature. The squamoid eccrine ductal carcinoma (SEDC) is a rare malignant variant that combines ductal structures with squamous differentiation. We report a case of dermoscopic and histological diagnosis of SEDC, treated with Mohs Surgery and with no recurrence of a tumour after 12 months of follow up. Read More

    Homeobox transcriptional factor engrailed homeobox 1 is expressed specifically in normal and neoplastic sweat gland cells.
    Histopathology 2018 Feb 12. Epub 2018 Feb 12.
    Department of Human Pathology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.
    Aims: A number of homeobox transcriptional factors are utilised as organ-specific markers in the histopathological diagnosis of neoplasms. We have screened a homeobox gene that is expressed specifically in normal sweat gland cells and is useful for the histopathological diagnosis of sweat gland neoplasms.

    Methods And Results: By screening an open database resource of The Human Protein Atlas, 37 genes among the 235 homeobox transcriptional factors were found to be expressed specifically in the skin. Read More

    Primary Cutaneous Mucinous Carcinoma with Extramammary Paget's Disease: Eccrine or Apocrine?
    J Pathol Transl Med 2018 Jan 25. Epub 2018 Jan 25.
    Department of Pathology, Kosin University Gospel Hospital, Busan, Korea.
    Primary cutaneous mucinous carcinoma (PCMC) is an uncommon tumor of the sweat gland origin. The occurrence of PCMC is mostly in middle-aged and older patients, with a slight male predominance. Most cases of PCMC arise on the head, with a preference for eyelids. Read More

    Microcystic adnexal carcinoma with sebaceous differentiation: Three cases.
    J Cutan Pathol 2018 Apr 15;45(4):290-295. Epub 2018 Feb 15.
    Private Practice, Friedrischafen, Friedrichshafen Dermatopathologie, Friedrischafen, Germany.
    Microcystic adnexal carcinoma (MAC) is a low-grade malignant tumor of the skin. Histologically, this tumor shows a biphasic pattern, with cords and nests of basaloid cells, as well as keratin horn cysts. This biphasic histological appearance has been interpreted by some authors as a sign of double eccrine and folliculosebaceous-apocrine differentiation, whereas some other authors defend a solely eccrine differentiation. Read More

    Primary mucinous eccrine carcinoma of the buccal space: A case report and review of the literature.
    Am J Otolaryngol 2018 Mar - Apr;39(2):242-246. Epub 2018 Jan 5.
    Department of Otolaryngology, Icahn School of Medicine at Mount Sinai, New York, NY, United States.
    Importance: Mucinous eccrine carcinoma is a rare entity that most commonly affects the head and neck. Due to its low frequency of occurrence, review of its etiology, histopathology, and treatment strategies is beneficial to all clinicians who may encounter similar appearing masses.

    Observation: An 84-year-old male presented with a blue mass on the left cheek. Read More

    A synchronous incidence of eccrine porocarcinoma of the forearm and facial squamous cell carcinoma: A case report.
    Int J Surg Case Rep 2018 8;42:116-120. Epub 2017 Dec 8.
    Department of Pathology, Sultanah Nur Zahirah Hospital, Jalan Sultan Mahmud, 20400, Kuala Terengganu, Terengganu, Malaysia.
    Introduction: Cutaneous appendageal tumor can differentiate towards or arise from either pilosebaceous apparatus or the eccrine sweat glands. Appendageal tumors are relatively rare, their clinical appearance is non-specific, and the vast majority are not diagnosed until after excision. Eccrine porocarcinoma (EP), also known as malignant eccrine poroma is a rare adnexal tumor arising from the intraepithelial ductal parts of the sweat gland. Read More

    Syringoid Eccrine Carcinoma of the Thigh.
    Ann Dermatol 2017 Dec 30;29(6):786-789. Epub 2017 Oct 30.
    Department of Dermatology, Kyung Hee University Hospital at Gangdong, Kyung Hee University School of Medicine, Seoul, Korea.
    Syringoid eccrine carcinoma (SEC) is a rare cutaneous malignant tumor thought to be derived from eccrine sweat apparatus. It is usually present in the head, neck and trunk region, and often occurs in the fourth to seventh decades of life. A 94-year-old male patient visited our department with an 80-year history of a lesion showing a 2×2 cm sized well-demarcated round shaped erythematous to pinkish colored nodule with ulcer on his left thigh. Read More

    Reticulated acanthoma with sebaceous differentiation mimicking melanoma.
    Dermatol Pract Concept 2017 Jul 31;7(3):35-37. Epub 2017 Jul 31.
    Department of Dermatology, Mogi das Cruzes University, Mogi das Cruzes, Brazil.
    Reticulated acanthoma with sebaceous differentiation (RASD) is a rare, benign cutaneous tumor with peculiar histopathologic characteristics [1]. RASD had been described under various synonyms such as superficial epithelioma with sebaceous differentiation, sebocrine adenoma, poroma with sebaceous differentiation, and seborrheic keratosis with sebaceous differentiation [2]. Clinical differential diagnosis of RASD includes cutaneous superficial epithelial neoplasia such as Bowen's disease, superficial basal cell carcinoma (BCC) and intraepidermal eccrine poroma [1]. Read More

    A case of massive porocarcinoma.
    Ann R Coll Surg Engl 2017 Nov 15;99(8):e230-e232. Epub 2017 Sep 15.
    Children's Surgical Centre , Phnom Penh , Cambodia.
    A 53-year-old Cambodian woman presented with nodular masses on the right arm suggestive of a sarcoma-type malignancy. The masses were excised and identified as multiple benign eccrine poromas. The patient re-presented after two years with large relapsed tumours and axillary lymph node involvement. Read More

    Concomitant poroma and porocarcinoma.
    An Bras Dermatol 2017 Jul-Aug;92(4):550-552
    Faculty of Medicine, Pontificia Universidad Católica de Chile - Santiago, Chile.
    Eccrine poromas and porocarcinomas are adnexal tumors derived from the sweat duct epithelium. However, eccrine poroma is benign in nature, whilst eccrine porocarcinoma is regarded as its malignant counterpart. We report the case of a man who presented simultaneously with an eccrine poroma and eccrine porocarcinoma. Read More

    Eccrine Poroma of the Postauricular Area.
    Arch Craniofac Surg 2017 Mar 25;18(1):44-45. Epub 2017 Mar 25.
    Department of Plastic and Reconstructive Surgery, Dongguk University College of Medicine, Gyeongju, Korea.
    Eccrine poroma is a common benign cutaneous tumor that originates in an intraepidermal eccrine duct. This tumor exhibits acral distribution (sole, palm), and is rarely encountered in the head and neck area. In fact eccrine poroma in the postauricular area has only been rarely reported. Read More

    Primary Cutaneous Mucinous Carcinoma of the Eyelid.
    Arch Craniofac Surg 2016 Sep 23;17(3):176-179. Epub 2016 Sep 23.
    Department of Pathology, Soonchunhyang University Seoul Hospital, Soonchunhyang University College of Medicine, Seoul, Korea.
    Primary cutaneous mucinous carcinoma (PCMC) is a rare low-grade malignant neoplasm derived from the eccrine glands. PCMC most commonly arises in the head and neck, with the eyelid being the most common site of origin. This case report describes a 51-year-old male with a painless, pigmented superficial nodular lesion over his right lower eyelid. Read More

    Primary Cutaneous Mucinous Carcinoma Treated with Narrow Surgical Margin.
    Arch Craniofac Surg 2016 Sep 23;17(3):158-161. Epub 2016 Sep 23.
    Department of Plastic and Reconstructive Surgery, Yonsei University Wonju College of Medicine, Wonju, Korea.
    Primary cutaneous mucinous carcinoma (PCMC) is a rare malignant tumor of eccrine origin. Clinically, the carcinoma presents as a solitary, slow growing, and painless nodule. For this reason, this tumor is often considered to be a benign mass in the preoperative setting. Read More

    Eosinophilic variant of eccrine porocarcinoma of the scalp: Case report and review of the literature.
    Int J Womens Dermatol 2017 Sep 14;3(3):157-160. Epub 2017 Jul 14.
    Department of Dermatology, University of Connecticut School of Medicine, Farmington, CT.
    Porocarcinoma is a rare malignant neoplasm of the acrosyringium with metastatic potential that most commonly presents on the acral skin in older adults (mean age = 72 years). We present the case of a 43-year-old woman who developed a rapidly growing de novo porocarcinoma on the scalp with an unusual oncocytic appearance. The tumor consisted of benign eccrine poroma that arose from the epidermis and broad pushing borders with minimal cytological atypia but ample eosinophilic cytoplasm with numerous mitotic figures. Read More

    Lichen Simplex Chronicus as an Essential Part of the Dermatologic Masquerade.
    Open Access Maced J Med Sci 2017 Jul 24;5(4):556-557. Epub 2017 Jul 24.
    Department of Dermatology, Venereology and Dermatologic Surgery, Medical Institute of Ministry of Interior, and Onkoderma Polyclinic for Dermatology and Dermatologic Surgery, Sofia, Bulgaria.
    A 48 years old female patient had been suffering from the lesions presented for four years. They have started as small, pruritic patches which had been mechanically irritated and grew up in time. The patient had no associated comorbidities or allergies, and she was not under any medication. Read More

    Dermal Substitutes Use in Reconstructive Surgery for Skin Tumors: A Single-Center Experience.
    Int J Surg Oncol 2017 2;2017:9805980. Epub 2017 Jul 2.
    Skin Cancer Department, AC Camargo Cancer Center, São Paulo, SP, Brazil.
    Reconstructive surgery following skin tumor resection can be challenging. Treatment options after removing the tumor are skin grafting, local pedicled and axial flaps, or microsurgery for complex and extensive wounds correction. Recently, the use of dermal substitutes has been extended to reconstructive surgery in cutaneous oncology. Read More

    F-18 FDG PET/CT Imaging of Eccrine Sweat Gland Carcinoma of the Scrotum with Extensive Regional and Distant Metastases.
    Asia Ocean J Nucl Med Biol 2017 ;5(2):104-108
    Department of Nuclear Medicine, Konyang University Hospital, Daejeon, Republic of Korea.
    Eccrine carcinoma is an extremely rare malignant skin cancer arising from eccrine sweat glands with a high metastatic potential. It mainly occurs in the elderly, with equal incidence in both sexes. It usually spreads to regional lymph nodes, with liver, lungs, and bones being the most common sites of distant metastasis. Read More

    Microcystic Adnexal Carcinoma: A Review of the Literature.
    Dermatol Surg 2017 Aug;43(8):1012-1016
    *Division of Dermatology, Department of Internal Medicine, Washington University, St. Louis, Missouri; †Department of Pathology and Immunology, Washington University, St. Louis, Missouri.
    Background: Microcystic adnexal carcinoma (MAC) is a rare, locally aggressive cutaneous neoplasm that commonly occurs on the face.

    Objective: The purpose of this article is to comprehensively review the current literature on MAC pertaining to epidemiology, pathogenesis, clinical presentation, histology, immunohistochemistry, prognosis, follow-up, and treatment.

    Materials And Methods: An extensive literature review was conducted using OVID MEDLINE and PubMed to identify articles relating to MAC. Read More

    Cost-effectiveness of Early Division of the Forehead Flap Pedicle.
    JAMA Facial Plast Surg 2017 Sep;19(5):418-420
    Division of Facial Plastic and Reconstructive Surgery, Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, California.
    Importance: The paramedian forehead flap is considered the gold standard procedure to optimally reconstruct major defects of the nose, but this procedure generally requires 2 stages, where the flap pedicle is divided 3 weeks following the initial surgery to ensure adequate revascularization of the flap from the surrounding recipient tissue bed, which can cost a patient time out of work or away from normal social habits. It has previously been shown that the pedicle may be safely divided after 2 weeks in select patients where revascularization from the recipient bed was confirmed using intraoperative laser fluorescence angiography to potentially save the patient time and money.

    Objective: To demonstrate the cost-effectiveness of takedown of the paramedian forehead flap pedicle after 2 weeks using angiography with indocyanine green (ICG). Read More

    Syringoid Eccrine Carcinoma of the Foot: Report of a Rare Cutaneous Adnexal Neoplasm.
    Int J Surg Pathol 2017 Oct 29;25(7):659-664. Epub 2017 May 29.
    1 Hartford Hospital, Hartford, CT, USA.
    Syringoid eccrine carcinoma is a rare malignant adnexal tumor that typically presents in the head and neck region. Involvement of the extremities is uncommon, with only a few cases reported in the literature. Here, we report our experience with a rare case of syringoid eccrine carcinoma occurring on the plantar surface of the right foot in a 47-year-old African American woman. Read More

    Neuroendocrine differentiation in basal cell carcinoma.
    J Immunoassay Immunochem 2017 26;38(5):487-493. Epub 2017 May 26.
    a Department of Pathology , The La Rabta Hospital, Tunis University , Bab Saadoun, Tunis.
    Basal cell carcinoma (BCC) is the prototypical basaloid tumor of the skin. It may show various patterns simulating other cutaneous tumors due to its pleomorphism. It may have an unusal pattern of differentiation such as squamous, sebaceous, apocrine, eccrine, pilar, and endocrine differentiation. Read More

    Fine needle aspiration cytology of primary cutaneous mucinous carcinoma of axilla-report of a rare case.
    Diagn Cytopathol 2017 Oct 24;45(10):934-938. Epub 2017 May 24.
    Department of Pathology, College of Medicine and Sagore Dutta Hospital, Kalpataru Apartment, Sahid colony, BT road, Sodepur, PO-Khardah, North 24 Parganas, West Bengal, India.
    Primary mucinous eccrine carcinoma is a rare malignant adnexal tumor of older patients. The histopathological features of this tumor are well-established but the cytomorphology of this neoplasm has only been documented in a few cases. The cytology and histology of this tumor may mimic metastatic mucinous carcinoma and may cause a diagnostic dilemma, especially when the tumor is located at axilla. Read More

    Hidroacanthoma simplex: dermoscopy and cryosurgery treatment.
    An Bras Dermatol 2017 Mar-Apr;92(2):253-255
    Department of Dermatology. Hospital do Servidor Público Estadual de São Paulo - São Paulo (SP), Brazil.
    Hidroacanthoma simplex is a rare intraepidermal neoplasia that arises from the acrosyringial portion of the eccrine duct. Malignant transformation of hidroacanthoma simplex is reported in the literature and the treatment is performed with wide excision or Mohs micrographic surgery. We report the first case successfully treated with cryosurgery with a long-term follow up. Read More

    Ductal eccrine carcinoma of the axilla: a diagnostic pitfall.
    An Bras Dermatol 2017 Mar-Apr;92(2):239-242
    Department of Dermatology, Instituto Português de Oncologia de Lisboa - Lisboa, Portugal.
    Ductal eccrine carcinoma (DEC) is a rare sweat gland carcinoma with ductular differentiation. Clinically, it is characterized by a slowly growing, hardened plaque or nodule predominantly located on the head and neck. Histologically, DEC shares similar features to invasive breast carcinoma, thus causing great diagnostic challenges. Read More

    [Hidradenocarcinoma of the heel associated with inguinal metastases].
    Ann Dermatol Venereol 2017 Aug - Sep;144(8-9):536-542. Epub 2017 May 18.
    Service de dermatologie, CHU d'Ibn-Rochd, Casablanca, Maroc.
    Background: Hidradenocarcinoma is a rare malignant tumour involving the sweat glands. It classically arises de novo, only rarely resulting from pre-existing hidradenoma. The literature contains few reports of lymph node metastasis in this tumour. Read More

    Aggressive digital papillary adenocarcinoma: A clinicopathological study of 19 cases.
    J Am Acad Dermatol 2017 Sep 9;77(3):549-558.e1. Epub 2017 May 9.
    Department of Dermatology, Strasbourg University Hospital, Strasbourg, France.
    Background: Aggressive digital papillary adenocarcinomas (ADPA) are malignant tumors of sweat glands having recurrence/metastatic potential.

    Objective: We sought to describe the clinical/histopathological characteristics of a series of ADPA.

    Methods: This is a retrospective case series of 19 ADPA. Read More

    Circulating TNF receptors predict cardiovascular disease in patients with chronic kidney disease.
    Medicine (Baltimore) 2017 May;96(19):e6666
    aDepartment of Internal Medicine, Gyeongsang National University Changwon Hospital, Changwon bDepartment of Internal Medicine, National Medical Center cDepartment of Internal Medicine, Seoul National University College of Medicine dDepartment of Internal Medicine, Seoul National University Boramae Medical Center, Seoul eDepartment of Internal Medicine, Dongguk University Medical Center, Gyeongju fDepartment of Internal Medicine, Dong-A University, Busan gDepartment of Dental Hygiene, College of Health Science, Eulji University, Seongnam hDepartment of Internal Medicine, Yonsei University College of Medicine, Seoul iDepartment of Internal Medicine, Dongguk University Medical Center, Goyang jKidney Research Institute, Seoul National University, Seoul, Republic of Korea.
    Cardiovascular disease (CVD) is the main public health problem in patients with chronic kidney disease (CKD); however, there is no established biomarker for predicting CVD morbidity and mortality in CKD. The aim of this study was to evaluate the role of circulating tumor necrosis factor receptors (cTNFRs) in predicting CVD risk in CKD patients.We prospectively recruited 984 patients with CKD from 11 centers between 2006 and 2012. Read More

    Update on Malignant Sweat Gland Tumors.
    Surg Pathol Clin 2017 Jun 27;10(2):383-397. Epub 2017 Mar 27.
    Department of Pathology, Western General Hospital, Alexander Donald Building, 1st Floor, Crewe Road, Edinburgh EH4 2XU, UK. Electronic address:
    Malignant sweat gland tumors are rare cutaneous neoplasms, traditionally separated according to their behavior into low- and high-grade malignant. There is significant morphologic overlap, and outright malignant tumors may show relatively bland histologic features. They may, therefore, be mistaken easily for benign neoplasms. Read More

    Adnexal Carcinomas Treated With Mohs Micrographic Surgery: A Comprehensive Review.
    Dermatol Surg 2017 Oct;43(10):1199-1207
    Surgical Dermatology Group, Birmingham, Alabama.
    Background: Adnexal carcinomas (ACs) are rare cutaneous malignancies of sweat gland or pilosebaceous origin. Optimal treatment and metastatic potential of AC are poorly defined. Mohs micrographic surgery (MMS) has been increasingly used to treat AC. Read More

    Head and neck sweat gland adenocarcinoma: A population-based perspective of a rare entity.
    Laryngoscope 2017 Dec 11;127(12):2757-2762. Epub 2017 Apr 11.
    Department of Otolaryngology-Head and Neck Surgery.
    Objectives: Head and neck sweat gland adenocarcinoma (HNSGA) is an extremely rare malignancy. We present the first population-based analysis regarding this entity.

    Study Design: Retrospective population-based analysis. Read More

    GREM1 is expressed in the cancer-associated myofibroblasts of basal cell carcinomas.
    PLoS One 2017 27;12(3):e0174565. Epub 2017 Mar 27.
    Department of Pathology, Jeju National University School of Medicine and Jeju National University Hospital, Jeju, South Korea.
    Cancer-associated fibroblasts (CAFs) play important roles in cancer progression through their complex interactions with cancer cells. The secreted bone morphogenetic protein antagonist, gremlin1 (GREM1) is expressed by the CAFs of basal cell carcinomas (BCCs), and promotes the growth of cancer cells. In this study, we investigated the expression of GREM1 mRNAs in various benign and malignant skin tumors, including various BCC subtypes. Read More

    SOX10 immunohistochemistry in sweat ductal/glandular neoplasms.
    J Cutan Pathol 2017 Jun 20;44(6):544-547. Epub 2017 Apr 20.
    San Diego Pathologists Medical Group, San Diego, California.
    Background: SOX10 is a newer Schwannian and melanocytic marker that has generated great interest for its relative sensitivity and specificity in the diagnosis of neural crest-derived tumors. Previous studies with SOX10 have shown positive immunohistochemical expression in cutaneous eccrine glands and negative expression in eccrine ducts, apocrine glands and hair follicles. Thus, we hypothesized that some sweat gland tumors of presumed eccrine origin would be positive for SOX10, whereas apocrine-derived sweat gland tumors would not. Read More

    GATA3 and MYB Expression in Cutaneous Adnexal Neoplasms.
    Am J Dermatopathol 2017 Apr;39(4):279-286
    *Departments of Pathology, Porto Medical School and Sao Joao Hospital, Porto, Portugal; †Departments of Pathology, William Beaumont School of Medicine, Royal Oak, MI; ‡Departments of Pathology, Duke University Medical Center, Durham, NC; and §Departments of Pathology, Harvard Medical School and Massachusetts General Hospital, Boston, MA.
    Knowledge of staining pattern of certain immunostains might be useful in the classification of cutaneous adnexal tumors that can have clinical importance. We studied GATA3 and MYB expression in archival materials of 220 adnexal tumors comprised of sebaceous carcinomas, follicular tumors, apocrine carcinoma, predominantly apocrine tumors, predominantly eccrine tumors, and others including adenoid cystic carcinomas. Nuclear GATA3 expression was seen in 70% (153/220) of cases, including sebaceous carcinoma (93%), apocrine carcinoma (93%), follicular neoplasms (100%), and predominantly apocrine neoplasms (69%), yet only 38% of predominantly eccrine neoplasms. Read More

    Primary Cribriform Carcinoma of the Eyelid With Neuroendocrine Features: A Case Report.
    J Drugs Dermatol 2017 Feb;16(2):173-174
    A variety of tumors may involve the eyelid, most of which are primary, but rarely can be metastatic. Previously reported eyelid primary carcinomas with neuroendocrine features include Merkel cell carcinoma, apocrine and eccrine gland carcinoma, sebaceous gland carcinoma, and one report of primary "well-differentiated neuroendocrine tumor." Herein we report the first case of primary cribriform carcinoma of the eyelid with neuroendocrine features. Read More

    [Malignant transformation of an eccrine spiradenoma].
    Ann Dermatol Venereol 2017 Mar 27;144(3):203-207. Epub 2016 Oct 27.
    Service de pathologie, centre hospitalier Lyon sud, 165, chemin du Grand-Revoyet, 69495 Pierre-Bénite, France.
    Introduction: Malignant eccrine spiradenoma is a rare and aggressive tumor, developed on the epithelium of eccrine sweat glands. Typically, it occurs after malignant transformation of benign eccrine spiradenoma, but sometimes it happens de novo.

    Observation: We report a case of malignant eccrine spiradenoma in a 62-year-old woman. Read More

    [A Case of Breast Metastasis of Eccrine Porocarcinoma].
    Gan To Kagaku Ryoho 2016 Nov;43(12):2016-2018
    Dept. of Surgery, Shiga University of Medical Science.
    An 80's woman was diagnosed with eccrine porocarcinoma of the head in 2010.T he tumor was removed surgically but relapsed in the cervical and axillary lymph nodes 2 years later.The patient underwent surgery, and received systemic chemotherapy and radiation. Read More

    Eccrine Porocarcinoma: Patient Characteristics, Clinical and Histopathologic Features, and Treatment in 7 Cases.
    Actas Dermosifiliogr 2017 May 19;108(4):e27-e32. Epub 2017 Jan 19.
    Servicio de Dermatología Médico-Quirúrgica y Venereología, Hospital Universitario Príncipe de Asturias, Universidad de Alcalá, Alcalá de Henares, Madrid, España.
    Eccrine porocarcinoma is a rare, malignant cutaneous adnexal tumor that arises from the ducts of sweat glands. Found mainly in patients of advanced age, this tumor has diverse clinical presentations. Histology confirms the diagnosis, detects features relevant to prognosis, and guides treatment. Read More

    Squamoid eccrine ductal carcinoma.
    An Bras Dermatol 2016 Nov-Dec;91(6):799-802
    Universidade de São Paulo (USP) - São Paulo (SP), Brazil.
    Squamoid eccrine ductal carcinoma is an eccrine carcinoma subtype, and only twelve cases have been reported until now. It is a rare tumor and its histopathological diagnosis is difficult. Almost half of patients are misdiagnosed as squamous cell carcinoma by the incisional biopsy. Read More

    MYB, CD117 and SOX-10 expression in cutaneous adnexal tumors.
    J Cutan Pathol 2017 May 14;44(5):444-450. Epub 2017 Feb 14.
    Departments of Dermatology and Pathology, University of California, San Francisco, California.
    Background: Elevated MYB expression has been documented in adenoid cystic carcinoma (ACC), cylindroma, and spiradenoma, but the specificity of this finding is unknown. CD117 and SOX-10 expression also occurs in some cutaneous adnexal tumors. This study assesses MYB, CD117 and SOX-10 expression in cutaneous adnexal tumors. Read More

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