1,138 results match your criteria Eccrine Carcinoma


Squamoid Eccrine Ductal Carcinoma of the Eyelid: Clinicopathologic Correlation of a Case.

Ophthalmic Plast Reconstr Surg 2022 May-Jun 01;38(3):e80-e82. Epub 2022 Apr 4.

Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida.

Squamoid eccrine ductal carcinoma (SEDC) is a rare cutaneous neoplasm that often manifests as a plaque or nodule in sun-exposed areas of older patients. Herein, the authors report the first case of SEDC in the eyelid. A 76-year-old man presented with a 2. Read More

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Dermoscopy of cutaneous adnexal tumors: a systematic review of the literature.

J Eur Acad Dermatol Venereol 2022 May 10. Epub 2022 May 10.

Centro Oncologico ad Alta Tecnologia Diagnostica, Azienda Unità Sanitaria Locale - IRCCS di Reggio Emilia, Italy.

Cutaneous adnexal tumors (ATs) encompass a variegated group of hamartomas and benign or malignant tumors, originating from the hair follicle, sebaceous, eccrine or apocrine glands that may simulate other cutaneous neoplasms. This study aims to provide a comprehensive overview of the spectrum of clinical and dermoscopic features of ATs, to better define these lesions and assist in differential diagnosis. We performed a two-step systematic search of literature in PubMed, Embase, and Cochrane Library databases from inception until September 4, 2020. Read More

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Incidence and trends of cutaneous adnexal tumors in the United States in 2000-2018: A population-based study.

J Am Acad Dermatol 2022 May 4. Epub 2022 May 4.

Department of Dermatology, Emory University School of Medicine, Atlanta, Georgia; Winship Cancer Institute of Emory University School of Medicine, Atlanta, Georgia; Atlanta VA Health Care System, Decatur, Georgia.

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Poorly Differentiated Eccrine Carcinomas are associated with Increased Risk for Poor Outcomes.

J Am Acad Dermatol 2022 Apr 27. Epub 2022 Apr 27.

Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts. Electronic address:

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Poorly Differentiated Metastatic Carcinoma of Possible Eccrine Sweat Gland Origin.

Am Surg 2022 Apr 24:31348221091944. Epub 2022 Apr 24.

Division Chief, Surgical Oncology, Department of Surgery, School of Medicine, 21693University of Mississippi Medical Center, Jackson, MS, USA.

Sweat gland carcinomas are a rare group of cancer, representing less than .01% of all diagnosed skin malignancies. We report the case of a 32-year-old male who presented with a fungating lesion on the posterolateral side of his left knee. Read More

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Eccrine Carcinoma With an Unknown Primary: Managing Occult Cancer Through Multidisciplinary Tumor Board Collaboration.

Cureus 2022 Mar 15;14(3):e23183. Epub 2022 Mar 15.

Radiation Oncology, Mount Auburn Hospital, Harvard Medical School, Cambridge, USA.

Eccrine carcinomas are rare cutaneous cancers that tend to be locally aggressive. Here we report a rare case of a mucinous eccrine carcinoma presenting in axillary lymph nodes without an identifiable primary lesion. This is a 69-year-old male with a past medical history of benign prostatic hyperplasia, melanoma, basal cell carcinoma, hypercholesterolemia, hypertension, and arthritis who was found to have an elevated prostate-specific antigen. Read More

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Eccrine Hidradenocarcinoma of the Scalp.

Cureus 2022 Mar 10;14(3):e23023. Epub 2022 Mar 10.

Medical Oncology, Instituto Português de Oncologia do Porto Francisco Gentil, EPE, Porto, PRT.

Eccrine hidradenocarcinoma is a rare adnexal neoplasm arising from the eccrine sweat glands of the skin. Surgery and radiotherapy are the mainstay of treatment, and chemotherapy is reserved for unresectable or metastatic lesions. We present the case of a 60-year-old man, referred for treatment of an unresectable basal cell carcinoma of the scalp. Read More

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MOC-31 Antibody Immunolabeling During Mohs Surgery.

Dermatol Surg 2022 Apr 5. Epub 2022 Apr 5.

Boston University School of Medicine, Boston, Massachusetts.

Background: Ber-EP4 is an antibody that labels basal cell carcinoma (BCC) by targeting epithelial cell adhesion molecule (Ep-CAM). MOC-31, a monoclonal mouse antibody, also targets Ep-CAM and is currently used to differentiate several extracutaneous epithelial tumors. However, the utility of MOC-31 has not been fully described in cutaneous tumors and in Mohs micrographic surgery (MMS). Read More

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UV-induced local immunosuppression in the tumour microenvironment of eccrine porocarcinoma and poroma.

Sci Rep 2022 04 1;12(1):5529. Epub 2022 Apr 1.

Department of Pathology, University of Helsinki, P.O. Box 63, 00014, Helsinki, Finland.

Eccrine porocarcinoma (EPC) is a rare malignant adnexal tumour of the skin. Part of EPCs develop from their benign counterpart, poroma (EP), with chronic light exposure and immunosuppression hypothesized to play a role in the malignant transformation. However, the impact of chronic light exposure on the microenvironment of EPCs and EPs has not been investigated yet. Read More

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The role of postoperative radiotherapy in eccrine porocarcinoma: a multidisciplinary systematic review.

Eur Rev Med Pharmacol Sci 2022 Mar;26(5):1695-1700

U.O.C. Radioterapia Oncologica, Dipartimento di Diagnostica per Immagini, Radioterapia Oncologica ed Ematologia, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.

Objective: Eccrine porocarcinoma (EPC) is a malignant adnexal tumor accounting for about 0.005% of skin tumors. The standard treatment of EPC is the complete surgical excision of the primary lesion and of the clinically involved lymph nodes. Read More

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Squamoid Eccrine Ductal Carcinoma: Treatment and Outcomes.

Am J Dermatopathol 2022 Apr;44(4):249-253

Division of Dermatology, Department of Medicine, University of Ottawa and The Ottawa Hospital, Ottawa, Ontario, Canada.

Background: Squamoid eccrine ductal carcinoma (SEDC) represents a subtype of eccrine carcinomas that are diagnostically challenging for both clinicians and dermatopathologists.

Objective: To provide an updated review of SEDC and examine patient outcomes with different treatment modalities.

Methods: A review of Ovid MEDLINE was performed to review the English language medical literature of SEDC. Read More

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Breast metastases of eccrine porocarcinoma.

BMJ Case Rep 2022 Mar 7;15(3). Epub 2022 Mar 7.

Breast Unit, Champalimaud Clinical Center / Champalimaud Foundation, Lisbon, Portugal.

Eccrine porocarcinoma is a rare skin adnexal malignant neoplasm that may arise from a pre-existing benign eccrine poroma or without a predisposing factor. It is a highly invasive neoplasm and has a strong metastatic potential. The most frequently affected organs are the lymph nodes and rarely solid organs such as the liver, lungs and breast. Read More

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Treatment of Malignant Adnexal Tumors of the Skin: A 12-Year Perspective.

Cancers (Basel) 2022 Feb 16;14(4). Epub 2022 Feb 16.

Department of Soft Tissue/Bone Sarcoma and Melanoma, Maria Sklodowska-Curie National Research, Institute of Oncology, 02-781 Warsaw, Poland.

Malignant adnexal cancers of the skin-extremely rare neoplasms-are mostly reported as non-symptomatic, slow-growing nodules. These carcinomas occur mainly in the middle-aged (50-60 years of age); they are mostly localized on the upper part of the body and are locally aggressive, infiltrate surrounding tissue, and metastasize to regional lymph nodes. The patients' outcomes depend on multiple prognostic factors, including the size of the primary tumor and its mitotic count. Read More

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February 2022

TROP2 Expression in Sebaceous and Sweat Gland Carcinoma.

J Clin Med 2022 Jan 25;11(3). Epub 2022 Jan 25.

Department of Dermatology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan.

Sebaceous carcinoma and sweat gland carcinoma (malignant tumors with apocrine and eccrine differentiation) are rare malignant skin adnexal tumors that differentiate toward sebaceous gland and eccrine and apocrine glands, respectively. Owing to the rarity of these carcinomas, standard treatments for advanced disease have not been established. Because the prognosis of patients with systemic metastasis is poor, a new treatment for these diseases is eagerly desired. Read More

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January 2022

Porocarcinoma: a review.

Clin Exp Dermatol 2022 Feb 11. Epub 2022 Feb 11.

Norwich Medical School, University of East Anglia, Norwich, UK.

From the first report in 1969 to the present day, diagnosis of eccrine porocarcinoma, also known simply as porocarcinoma (PC), remains a challenge. This review presents a concise update of the history, pathogenesis, epidemiology, diagnosis, management and prognosis of this rare sweat gland neoplasm. PC differentiates towards the intraepidermal spiral ducts in the eccrine gland, is more common in people aged > 60 years and often affects the head, neck and legs. Read More

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February 2022

Unusual Presentations of Eccrine Porocarcinomas.

Skin Appendage Disord 2022 Jan 8;8(1):61-64. Epub 2021 Sep 8.

Dermatology & Surgery Clinic, Singapore, Singapore.

Eccrine porocarcinomas (EPCs) are rare tumours, albeit the most common malignant adnexal tumours of the skin. They can present with very heterogeneous clinical and dermoscopic features, rendering diagnosis limited to histopathological examination alone. We share 2 cases of EPCs, one of which arose in a patient with a prior diagnosis of cutaneous squamous cell carcinoma (SCC) and another whose EPC was likely a malignant transformation of an existing poroma. Read More

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January 2022

A novel technique for forehead and eyebrow reconstruction using a temporal hairline flap combined with a free forearm flap: a report of two cases.

J Surg Case Rep 2022 Jan 30;2022(1):rjac004. Epub 2022 Jan 30.

Department of Plastic and Reconstructive Surgery, Kansai Medical University, Osaka, Japan.

We herein report a novel technique for managing large forehead skin defects that include the eyebrows and upper eyelid. Case 1 was of a 55-year-old woman with an eccrine carcinoma (T2N0M0) at the right forehead, resulting in a skin defect 15 cm in diameter. Case 2 was of an 81-year-old man with a malignant peripheral nerve sheath tumor (T1a N0M0) at the left forehead, resulting in a skin defect 18 cm in diameter. Read More

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January 2022

Acquired nasolacrimal duct obstruction: clinical and histological findings of 275 cases.

BMC Ophthalmol 2022 Jan 5;22(1):12. Epub 2022 Jan 5.

Centre of Eye Diseases, Vilnius University Hospital Santaros Klinikos, Santariskiu 2, LT-08661, Vilnius, Lithuania.

Background: Acquired nasolacrimal duct obstruction is a blockage of the lacrimal outflow system usually caused by local nonspecific inflammation of the lacrimal sac and the nasolacrimal duct. However, cases exist where the primary nasolacrimal system obstruction is caused by malignancies. Our aim was to investigate lacrimal sac pathologies in patients with acquired nasolacrimal duct obstruction and compare their clinical manifestations. Read More

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January 2022

Poroid hidradenocarcinoma and atypical hidradenoma papilliferum of the vulva - Two cases.

Gynecol Oncol Rep 2021 Nov 25;38:100886. Epub 2021 Oct 25.

Department of Gynaecological Oncology, Mercy Hospital for Women, Heidelberg, Victoria, Australia.

Benign and malignant tumours may arise from eccrine and apocrine sweat glands. Hidradenocarcinoma is a rare malignant eccrine sweat gland tumour representing <0.01% of all skin cancers. Read More

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November 2021

Case Report: Dermoscopic, High-Frequency Ultrasound, Contrast-Enhanced Ultrasound Appearances and Special Treatment of a Patient With Syringoid Eccrine Carcinoma on the Chest.

Front Oncol 2021 15;11:717581. Epub 2021 Nov 15.

Department of Dermatology, The Fifth Central Hospital of Tianjin, Tianjin, China.

This article aims to explain the use of a variety of noninvasive of minimally invasive examinations to obtain reliable diagnostic clues. The choice of treatment methods and repair techniques for wound defects are also critical in terms of the prognosis. Here, we describe the case of a 53-year-old male patient who visited our dermatology clinic due to a red plaque on the inner side of his left nipple without any symptoms for more than 30 years. Read More

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November 2021

Primary Eccrine Porocarcinoma of the Thumb With Metastasis: A Rare Case Report and Literature Review.

Am J Dermatopathol 2021 Dec;43(12):e285-e289

Department of Dermatology and Venerology, the First Affiliated Hospital, Sun Yat-sen University, Guangdong, China.

Abstract: Eccrine porocarcinoma (EPC) is a rare malignant sweat gland tumor that accounts for approximately 0.005% of all cutaneous carcinomas. It favors the lower extremities. Read More

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December 2021

Porocarcinoma: a rare cause of lateral cervical tumor.

Arch Clin Cases 2019 27;6(2):53-58. Epub 2021 Oct 27.

"Grigore T. Popa" University of Medicine and Pharmacy, Iasi, Romania.

Porocarcinoma is a rare tumor of the eccrine sweat glands that usually disseminates to the regional lymph nodes, but it can also develop distant metastasis. Case presentation: We report the case of a 67 year-old female patient who underwent wide surgical resection of a left cervical cutaneous tumor in a primary care center, for which the histology exam of the specimen was mixed basal cell and squamous cell carcinoma. She was referred to our hospital's oncology clinic and histologic re-evaluation changed the diagnosis to eccrine porocarcinoma (EPC). Read More

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October 2021

Expression and Significance of AQP3 in Cutaneous Lesions.

Anal Cell Pathol (Amst) 2021 26;2021:7866471. Epub 2021 Oct 26.

Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Pathology, Peking University Cancer Hospital & Institute, Beijing, China.

Aquaporin 3 (AQP3) is the membrane channel of water and involved in fluid homeostasis. The aim of this study was to reveal the expression and significance of AQP3 in cutaneous lesions. We analyzed AQP3 mRNA levels using RT-PCR in 311 cutaneous lesions and confirmed AQP3 expression in these lesions by immunohistochemistry. Read More

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Eccrine spiradenoma mimicking adenoid cystic carcinoma cytologically (Two case reports and literature review).

Diagn Cytopathol 2022 Jan 15;50(1):E6-E12. Epub 2021 Sep 15.

Department of Pathology, University of Health Sciences, Istanbul Training and Research Hospital, Istanbul, Turkey.

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January 2022

Sweat-gland carcinoma with neuroendocrine differentiation (SCAND): a clinicopathologic study of 13 cases with genetic analysis.

Mod Pathol 2022 01 12;35(1):33-43. Epub 2021 Sep 12.

Department of Dermatologic Oncology, Osaka International Cancer Institute, Osaka, Japan.

Low-grade neuroendocrine carcinoma of the skin (LGNECS) was proposed in 2017 as a new primary cutaneous neoplasm with neuroendocrine differentiation; however, it is not yet well known due to its rarity. Herein, we perform a detailed clinicopathologic analysis of 13 cases as well as panel DNA sequencing in three cases. The study included 12 males and 1 female with a median age of 71 (43-85) years. Read More

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January 2022

A Case of Eccrine Mucinous Carcinoma Involving Scalp.

Cureus 2021 Jul 18;13(7):e16469. Epub 2021 Jul 18.

Dermatology, The Queen Elizabeth Hospital, Adelaide, AUS.

The report presents a case of a 67-year-old female with a long-standing lump on the scalp. After its excision the histopathology revealed consistency with eccrine mucinous carcinoma. These neoplasms are quite rare with only around 100 cases reported since 1951. Read More

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Recurrent Squamoid Eccrine Ductal Carcinoma After Mohs Micrographic Surgery.

Dermatol Surg 2021 08;47(8):1108-1110

Department of Dermatology, Naval Medical Center, San Diego, California.

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PIGMENTED NODULAR CYSTIC HIDRADENOMA OF THE ANKLE.

Georgian Med News 2021 Jun(315):7-9

3Clinica Goldman and Hospital Moinhos de Vento, Porto Alegre/ RS, Brazil.

Solid-cystic hidradenoma is a benign cutaneous tumor that is most commonly found in the head, neck, trunk, and upper extremity regions of patients in the middle to older aged groups. Presentation on lower extremities and in particular on the foot is uncommon. Nodular hidradenomas represent a dermatological pitfall, being difficult to differentiate from basal cell carcinoma and melanoma. Read More

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Squamoid Eccrine Ductal Carcinoma.

Cutis 2021 Jun;107(6):E5-E9

Drs. Svoboda, Rush, Grider, Prickett, and Phillips are from Virginia Tech Carilion School of Medicine, Roanoke. Drs. Rush, Grider, Prickett, and Phillips are from the Section of Dermatology, Department of Internal Medicine. Drs. Rush and Grider also are from the Department of Basic Science Education. Dr. Garofola is from the Department of Dermatology, LewisGale Hospital Montgomery, Blacksburg, Virginia.

Squamoid eccrine ductal carcinoma (SEDC) is a rare and under-recognized primary cutaneous tumor with a high risk for local recurrence and metastasis. The tumor has a biphasic histologic appearance consisting of a superficial portion indistinguishable from squamous cell carcinoma (SCC) and a deeper component demonstrating eccrine ductal differentiation. Because of superficial sampling, SEDC often is misdiagnosed as SCC during the initial biopsy. Read More

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Merkel cell polyomavirus is a passenger virus in both poroma and porocarcinoma.

J Cutan Pathol 2022 Jan 11;49(1):49-54. Epub 2021 Aug 11.

Department of Plastic Surgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.

Background: Merkel cell polyomavirus (MCPyV) has been studied in several malignant and nonmalignant tissues. However, only in Merkel cell carcinoma (MCC) has the connection to tumorigenesis been established. Previously, eccrine porocarcinoma samples were shown to express MCPyV in the majority of samples. Read More

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January 2022