4,317 results match your criteria Eccrine Carcinoma
J Hum Evol 2018 Dec 7;125:99-105. Epub 2018 Nov 7.
Department of Human Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA. Electronic address:
Humans differ in many respects from other primates, but perhaps no derived human feature is more striking than our naked skin. Long purported to be adaptive, humans' unique external appearance is characterized by changes in both the patterning of hair follicles and eccrine sweat glands, producing decreased hair cover and increased sweat gland density. Despite the conspicuousness of these features and their potential evolutionary importance, there is a lack of clarity regarding how they evolved within the primate lineage. Read More
J Dermatol Sci 2018 Nov 10. Epub 2018 Nov 10.
Department of Biochemistry and Molecular Genetics, American University of Beirut, Beirut, Lebanon. Electronic address:
Background: Cutaneous malformations are at times associated with some forms of congenital heart defects. Many a times subtle cutaneous phenotypes maybe overlooked as their significance on the lives of individuals is minimal. Lebanon represents an area of high consanguinity, where the rates can go beyond 70% in some districts. Read More
An Bras Dermatol 2018 Nov/Dec;93(6):896-898
Service of Dermatology, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo (SP), Brazil.
Poroid neoplasms are benign epithelial proliferations with eccrine sweat gland differentiation. They are a challenging diagnosis because of the clinical heterogeneity, being able to mimic several malignant neoplasms. They are classified into classic poroma, hidroacanthoma simplex, dermal duct tumor and poroid hidradenoma. Read More
An Bras Dermatol 2018 Nov/Dec;93(6):893-895
Dermatology Service, Hospital do Servidor Público Estadual de São Paulo, São Paulo (SP), Brazil.
Squamoid eccrine ductal carcinoma is a cutaneous malignancy that originates from the eccrine sweat gland. A 76-year-old woman presented with an asymptomatic papule on her nose that had been present for one year. Dermoscopy showed pseudocysts, irregular linear crown vessels, and yellowish-brown globules surrounded by white halos. Read More
Am J Otolaryngol 2019 Jan - Feb;40(1):110-114. Epub 2018 Sep 22.
Department of Otorhinolaryngology - Head and Neck Surgery, Rush University Medical Center, Chicago, IL, United States of America.
Objectives: Malignant cutaneous adnexal tumors (MCAT) are rare and comprise a heterogeneous group of cancers. There have been several studies reviewing prognostic factors of these tumors, but no studies focusing on the head and neck. This study aimed to review a large population based database to evaluate prognostic factors that could impact survival. Read More
J Cutan Pathol 2018 Nov 22. Epub 2018 Nov 22.
Departments of Dermatology and Pediatrics, Columbia University Medical Center, New York, New York.
We report a case of disseminated Trichosporon asahii in a patient on systemic anti-fungal therapy who presented with multiple cutaneous nodules suggestive of fungal infection. Histologic features resembled neutrophilic eccrine hidradenitis but staining with periodic acid-Schiff and Gomori methenamine silver confirmed the clinical diagnosis. This case highlights the importance of maintaining suspicion for trichosporonosis and contextualizing histologic findings within the underlying clinical picture. Read More
Virchows Arch 2018 Nov 22. Epub 2018 Nov 22.
Pathology & Cytology Dalarna, County hospital Falun, Falun, Sweden.
Eccrine ductal and acrosyringeal metaplasia was described in 2006 as the presence of tumor structures that resemble the epithelium of the eccrine skin ducts and their opening within the epidermis, the acrosyringeum. Here, we report the clinical, morphological, and phenotypic characteristics of eight breast carcinomas that we collected over the past years showing this metaplasia. Unlike squamous metaplasia, acrosyringeal and eccrine ductal metaplasia are luminated structures comprising cells with eosinophilic cytoplasm that are easily detectable in routine histological slides. Read More
Yi Chuan 2018 Nov;40(11):1024-1032
National Engineering Laboratory for Forensic Science, Key Laboratory of Forensic Genetics of Ministry of Public Security, Beijing Engineering Research Center of Crime Scene Evidence Examination, Institute of Forensic Science, Ministry of Public Security, Beijing 100038, China.
The ectodysplasinA receptor gene (EDAR) plays an important role in the development of ectoderm. The derived G allele of its key missense variant EDARV370A is prevalent in East Asians and Americans, but rare in Africans and Europeans. This leads to distinct ectodermal-derived phenotypes between different continental groups, such as the straighter and thicker hair, more eccrine sweat glands, feminine smaller breasts, shovel incisors characteristic of East Asians. Read More
Handb Clin Neurol 2018 ;157:701-714
Biomedical Sciences, Marian University College of Osteopathic Medicine, Indianapolis, IN, United States.
Multiple sclerosis (MS) is a progressive neurologic disorder that disrupts axonal myelin in the central nervous system. Demyelination produces alterations in saltatory conduction, slowed conduction velocity, and a predisposition to conduction block. An estimated 60-80% of MS patients experience temporary worsening of clinical signs and neurologic symptoms with heat exposure (Uhthoff's phenomenon). Read More
Clin Case Rep 2018 Nov 17;6(11):2086-2088. Epub 2018 Sep 17.
Department of Dermatology and Venereology Ibn Sina University Hospital Rabat Morocco.
Eccrine spiradenoma is a benign and rare adnexal tumor originating from cutaneous eccrine sweat glands. It usually presents as a solitary lesion. It can have different presentations, including a blaschkoid arrangement which is rare. Read More
Handb Clin Neurol 2018 ;156:233-247
Laboratory for Exercise and Environmental Physiology, Department of Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, British Columbia, Canada. Electronic address:
The human autonomic nervous system participates in the control of thermoregulatory responses that are employed to regulate core temperature following deviations of skin temperature and/or core temperature from their respective resting values. This permits a regulation of the core temperature (T) at 37.0 ± 1°C with superimposed circadian variations in both sexes and menstrual cycle-associated variations in premenopausal women. Read More
Handb Clin Neurol 2018 ;156:211-232
Institute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital Dallas and University of Texas Southwestern Medical Center, Dallas, TX, United States.
In humans, sweating is the most powerful autonomic thermoeffector. The evaporation of sweat provides by far the greatest potential for heat loss and it represents the only means of heat loss when air temperature exceeds skin temperature. Sweat production results from the integration of afferent neural information from peripheral and central thermoreceptors which leads to an increase in skin sympathetic nerve activity. Read More
Am Surg 2018 Aug;84(8):e307-e308
Conemaugh Memorial Medical Center, Johnstown, Pennsylvania, USA.
Conf Proc IEEE Eng Med Biol Soc 2018 Jul;2018:854-857
The sweat gland and peripheral vessels underneath skin are a typical minute organ governed by the sympathetic nerve, and have important physiology functions to control of body temperature and maintenance. In this paper, we demonstrated the dynamic analysis of the mental sweating of the eccrine sweat glands and the dynamics of the small artery of human finger by optical coherence tomography (OCT). In the experiment of mental sweating, not only time variation of the amount of excess sweat can be evaluated simultaneously a few tens of sweat glands eccrine sweat glands but also the dynamics of peripheral vessels of a human finger were analyzed. Read More
Clin Exp Dermatol 2019 Jan 11;44(1):58-61. Epub 2018 Nov 11.
Department of Dermatology, Seth G.S Medical College and KEM Hospital, Mumbai, India.
Syringocystadenoma papilliferum (SCP) is a rare, benign, adnexal tumour of apocrine or eccrine differentiation. It is commonly located on head and neck region. We report the case of an 18-year-old woman who presented with a vulvar lobulated growth that was found to arise from the posterior lip of cervix. Read More
Skinmed 2018 9;16(5):351-352. Epub 2018 Nov 9.
Department of Dermatology, Research Unit "Genodermatoses and Cancers LR12SP03," Habib Thameur Hospital, Tunis, Tunisia.
A 52-year-old man was referred to our department with a 28-year history of painful nodular lesions located on his left buttock and left inguinal region that had recently increased in size and number. The lesions had developed progressively over many years. Cutaneous examination revealed multiple, well-circumscribed, subcutaneous, blue-gray nodules in a zosteriform distribution across the left inguinal region and the left buttock. Read More
Int J Surg Case Rep 2018 Oct 31;53:196-199. Epub 2018 Oct 31.
Department of Surgery, Chirurgia I- Ospedale Policlinico San Martino Genoa, Italy.
Introduction: Eccrine porocarcinoma (EPC) is a slow-growing carcinoma arising from the eccrine sweat glands. Based on its clinical presentation it can be confused with malignant and benign skin lesions, both. Histological examination is essential to formulate a correct diagnosis. Read More
JAAD Case Rep 2018 Nov 29;4(10):972-975. Epub 2018 Oct 29.
Department of Dermatology, University of Massachusetts Medical School, UMass Memorial Healthcare, Worcester, Massachusetts.
Am Surg 2018 Aug;84(8):e307-e308
Conemaugh Memorial Medical Center, Johnstown, Pennsylvania, USA.
G3 (Bethesda) 2018 Nov 5. Epub 2018 Nov 5.
University of Veterinary Medicine Hannover
In this study, we present a detailed phenotype description and genetic elucidation of the first case of X-linked hypohidrotic ectodermal dysplasia in the shorthaired standard Dachshund. This condition is characterized by partial congenital hypotrichosis, missing and malformed teeth and a lack of eccrine sweat glands. Clinical signs including dental radiographs and histopathological findings were consistent with ectodermal dysplasia. Read More
Exp Dermatol 2018 Nov 3. Epub 2018 Nov 3.
Wound Healing and Cell Biology Laboratory, The First Affiliated Hospital, General Hospital of the Chinese People's Liberation Army, 51 Fucheng Road, Beijing, 100048, China.
We previously showed three-dimensional (3D) reconstructed eccrine sweat glands have similar structures as native eccrine sweat glands, but whether the 3D reconstructed sweat glands appropriately secrete fluid is still unknown. In this study, Matrigel-embedded human eccrine sweat gland cells or Matrigel alone were implanted into the groin subcutis of the nude mice. Ten weeks post-implantation, images of the subcutaneously formed plugs, as well as footpads of rats, pre- and post-pilocarpine/normal saline (NS) injection were acquired using a fat-suppressed proton density-weighted magnetic resonance imaging (MRI) sequence at 7. Read More
Ir J Med Sci 2018 Oct 31. Epub 2018 Oct 31.
Department of Thoracic Surgery, Mater Misericordiae University Hospital, Eccles St., Dublin, Ireland.
Introduction: Pulmonary metastasectomy and indeed redo-pulmonary metastasectomy are now commonly performed thoracic surgical procedures. The air-sealant, haemostatic, and necrotic properties of the KLS Martin Limax Nd:YAG laser at 1.318 μm make it an ideal tool for limited lung resection such as metastasectomy. Read More
Temperature (Austin) 2018 6;5(3):257-266. Epub 2018 Sep 6.
Human and Environmental Physiology Research Unit, University of Ottawa, Ottawa, ON, Canada.
Protease-activated receptor 2 (PAR2) exists in the endothelial cells of skin vessels and eccrine sweat glands. We evaluated the hypothesis that exogeneous activation of PAR2 augments cutaneous vasodilatation and sweating during rest and exercise in the heat. In 10 young males (23 ± 5 y), cutaneous vascular conductance (CVC) and sweat rate were measured at four forearm skin sites treated with either 1) lactated Ringer (Control), 2) 0. Read More
Am J Dermatopathol 2018 Oct 24. Epub 2018 Oct 24.
Research Unit Dermatopathology, Department of Dermatology, Medical University of Graz, Graz, Austria.
Perieccrine inflammation may be observed in several different dermatoses, but true permeation of the secretory coil by lymphocytes (lymphocytic syringotropism) is a rather uncommon finding, usually observed in mycosis fungoides (MF-syringotropic MF). Rare cases of syringotropic lichen striatus and lymphocytic autoimmune hidradenitis showing a similar pattern have been described as well. We describe an exceptional case of lichen planus (LP) characterized by marked lymphocytic syringotropism with focal hyperplasia of the eccrine epithelium. Read More
Eur J Dermatol 2018 Oct 15. Epub 2018 Oct 15.
Department of Dermatology, National Defense Medical College, Tokorozawa, Japan.
J Eur Acad Dermatol Venereol 2018 Oct 5. Epub 2018 Oct 5.
Department of Dermatology, Medical University of Warsaw, Warsaw, Poland.
Introduction: Alopecia areata and frontal fibrosing alopecia are common causes of eyebrow loss (madarosis).
Objective: Assessment of trichoscopic markers of eyebrow loss in alopecia areata and frontal fibrosing alopecia.
Materials And Methods: The analysis included 50 patients with scalp alopecia areata with madarosis, 50 patients with scalp frontal fibrosing alopecia with madarosis and 50 healthy controls. Read More
J Am Acad Dermatol 2018 Oct 1. Epub 2018 Oct 1.
Case Western Reserve University School of Medicine Department of Dermatology, Cleveland, Ohio, U.S.A; University Hospitals Cleveland Medical Center, Cleveland, Ohio, U.S.A.
Australas J Dermatol 2018 Sep 30. Epub 2018 Sep 30.
Department of Dermatology, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
Int Wound J 2018 Sep 24. Epub 2018 Sep 24.
Nursing and Physical Therapy Department, Institute of Biomedicine (IBIOMED), Faculty of Health Sciences, Universidad de León, Ponferrada, León, Spain.
Primary hyperhidrosis (PH) is a common pathological condition related to excessive sweating. It may be associated with depression. Therefore, the main aim of this study was to analyse and compare depression scores between subjects without PH (degree-I) and patients with PH (degrees-II, -III, and -IV). Read More
J Pharm Sci 2018 Sep 19. Epub 2018 Sep 19.
The Procter and Gamble Company, Modeling and Simulation, Biological Systems, Brussels Innovation Center, Belgium.
A porous pathway feature has been added to an existing skin diffusion model to extend the range of applicability to highly polar solutes that do not readily diffuse across the stratum corneum (SC) lipid/corneocyte matrix. The porous pathway consists of 2 components: Pathway A is appendageal and is implemented as an array of aqueous shunts (the macropores), which themselves have microporous walls with transient aqueous pores (the micropores). Two varieties of shunts are discussed, one representing a terminal hair follicle and the other representing an eccrine sweat duct; however, the focus here is on the hair follicle. Read More
Int J Surg Case Rep 2018 12;51:277-281. Epub 2018 Sep 12.
Department of Plastic and Reconstructive Surgery, University Hospital of Foggia, Foggia, Italy.
Introduction: The authors present a "four-step" integrated surgical protocol to treat a rare case of multiple giant eccrine spiradenoma (ES) of the head and neck in a young patient.
Presentation Of Case: An 18-year-old female patient presented with multiple swellings in the head and neck regions. The patient had a severe psychological trauma with a negative impact on her social life. Read More
J Mol Histol 2018 Dec 20;49(6):567-575. Epub 2018 Sep 20.
Department of Burn and Plastic Surgery, The Second Affiliated Hospital, Shantou University Medical College, North Dongxia Road, Shantou, 515041, Guangdong, China.
Epidermal basal cells invaginate into the dermis to form sweat ducts, which then grow downwards further to form secretory coils during the ontogenesis of eccrine sweat glands, but the time course of differentiation of different cell types in 3D-reconstructed eccrine sweat glands remain unclear. In this study, secretory cell-specific marker K7, clear secretory cell-specific marker CA II, dark secretory cell-specific marker GCDFP-15, myoepithelial cell-specific marker α-SMA, inner duct cell-specific marker S100P and outer duct cell-specific marker S100A2 were detected by immunofluorescence staining. The results showed that S100P and S100A2 were first detected at 2 weeks post implantation, K7 and α-SMA at 3 weeks, and GCDFP-15 and CA II at 4 weeks. Read More
JAAD Case Rep 2018 Sep 18;4(8):835-836. Epub 2018 Sep 18.
Université Côte d'Azur, Centre Hospitalier Universitaire de Nice, Service de Dermatologie, Nice, France.
J Cutan Pathol 2018 Sep 10. Epub 2018 Sep 10.
Department of Dermatology, University of California San Francisco, San Francisco, California.
Background: Acantholysis can be seen in multiple skin diseases. Adnexal acantholysis has been regarded as a feature distinguishing pemphigus vulgaris (PV) from acantholytic conditions.
Methods: A retrospective review of the histopathologic features of diseases with acantholysis including PV, pemphigus foliaceus (PF), Hailey-Hailey disease (HHD), Darier disease (DD), Grover disease, and pityriasis rubra pilaris (PRP) was performed. Read More
Dermatol Clin 2018 Oct 16;36(4):397-412. Epub 2018 Aug 16.
Dermatology Department, Hospital General Universitario de Alicante, ISABIAL, C/Maestro Alonso 109, 03010 Alicante, Spain.
Cutaneous adnexal tumors include lesions with apocrine, eccrine, follicular, sebaceous, and mixed differentiation. Most are benign and sporadic, although malignant forms are occasionally observed and some cases develop in the setting of inherited syndromes. These tumors often cause immense diagnostic difficulty. Read More
Rev Alerg Mex 2018 Jul-Sep;65(3):219-223
Universidad de Antioquia, Grupo de Alergología Clínica y Experimental, Medellín, Colombia.
Background: Frey's syndrome is a group of symptoms that include unilateral sweating with malar region and external ear reddening after eating or drinking some food. It is a lesion of the auriculotemporal nerve that is secondary to surgery, parotid gland infection or facial trauma.
Clinical Cases: Three children between 4 and two and a half years of age: two girls and one boy. Read More
J Basic Clin Physiol Pharmacol 2018 Aug 13. Epub 2018 Aug 13.
School of Exercise and Nutritional Sciences, San Diego State University, San Diego, CA, USA.
Background: The purpose of this study was to measure sweat rate during exercise in the heat after directly inhibiting carbonic anhydrase (CA) in eccrine sweat glands via transdermal iontophoresis of acetazolamide. It was hypothesized that if CA was important for sweat production, local administration of acetazolamide, without the confounding systemic effects of dehydration typically associated with past studies, would have a significant effect on sweat rate during exercise.
Methods: Ten healthy subjects volunteered to exercise in the heat following acetazolamide or distilled water iontophoresis on the forearm. Read More
Indian J Cancer 2017 Oct-Dec;54(4):695-696
Department of Pathology, 166 Military Hospital, Jammu, Jammu and Kashmir, India.
Eccrine spiradenoma is one of the rare adnexal tumors with eccrine differentiation; however, it is considered to have apocrine differentiation. Around 50 cases of eccrine spiradenoma have been reported in the literature. Due to vascularity and painful symptoms, it is often confused with the painful lesions of skin such as glomus tumor and angioleiomyoma. Read More
Chin Med J (Engl) 2018 Aug;131(16):1964-1968
Department of Burn and Plastic Surgery, The Second Affiliated Hospital, Shantou University Medical College, Shantou, Guangdong 515041, China.
Background: Previous studies demonstrate that eccrine sweat glands are innervated by both cholinergic and adrenergic nerves. However, it is still unknown whether the secretory coils and ducts of eccrine sweat glands are equally innervated by the sympathetic nerve fibers. To well understand the mechanisms on sweat secretion and reabsorption, the differential innervation of secretory coils and ducts in human eccrine sweat glands was investigated in the study. Read More
Allergol Int 2018 Oct 3;67(4):455-459. Epub 2018 Aug 3.
Department of Dermatology, Course of Integrated Medicine, Graduate School of Medicine, Osaka University, Osaka, Japan.
Sweat is a transparent hypotonic body fluid made from eccrine sweat glands. Various ingredients contained in sweat are involved in a broad sense in skin homeostasis including temperature regulation, skin moisture, and immune functions. Thus, sweat plays a major role in maintaining skin homeostasis. Read More
Clin Chim Acta 2018 Nov 24;486:151-155. Epub 2018 Jul 24.
Kowloon West Cluster Laboratory Genetic Service, Chemical Pathology Laboratory, Department of Pathology, Princess Margaret Hospital, Hong Kong. Electronic address:
Background: Juvenile neuronal ceroid lipofuscinosis (CLN3 disease) is a hereditary progressive neurodegenerative disease well documented among Caucasians, but such clinical data and genetic characterization is lacking among Asian populations.
Patient And Methods: A 13-year-old Chinese girl presented for diagnostic evaluation with retinitis pigmentosa, generalised tonic-clonic seizure and cerebellar ataxia. Electron microscopy of whole blood and skin biopsy, and mutation analysis of CLN3 gene with genomic DNA and cDNA, were performed. Read More
Indian Dermatol Online J 2018 Jul-Aug;9(4):288-289
Department of Dermatology and STDs, Dr RML Hospital and PGIMER, New Delhi, India.
Indian Dermatol Online J 2018 Jul-Aug;9(4):259-261
Department of Dermatology, Rutgers Robert Wood Johnson Medical School, Somerset, New Jersey, USA.
Eccrine poroma is a benign adnexal tumor that originates from the uppermost portion of the intraepidermal eccrine duct. It usually presents as a solitary tumor. Histopathology shows a monomorphic proliferation of cuboidal cells, which radially extend from the basal layer to the dermis. Read More
J Cutan Med Surg 2018 Jul 24:1203475418791558. Epub 2018 Jul 24.
1 Washington University School of Medicine in St. Louis, St. Louis, MO, USA.
J Appl Physiol (1985) 2018 Oct 19;125(4):1041-1050. Epub 2018 Jul 19.
Laboratory for Applied Human Physiology, Graduate School of Human Development and Environment, Kobe University , Kobe , Japan.
It remains unknown whether cutaneous adrenergic nerves functionally contribute to sweat production during exercise. This study examined whether cutaneous adrenergic nerve blockade attenuates sweating during incremental exercise, specifically in habitually trained individuals. Accordingly, 10 habitually trained and 10 untrained males (V̇o: 56. Read More
PLoS One 2018 16;13(7):e0200009. Epub 2018 Jul 16.
Department of Electrical Engineering and Computing Systems, University of Cincinnati, Cincinnati, Ohio, United States of America.
Non-invasive wearable biosensors provide real-time, continuous, and actionable health information. However, difficulties detecting diluted biomarkers in excreted biofluids limit practical applications. Most biomarkers of interest are transported paracellularly into excreted biofluids from biomarker-rich blood and interstitial fluid during normal modulation of cellular tight junctions. Read More
IEEE J Biomed Health Inform 2018 Jul 12. Epub 2018 Jul 12.
This article documents thermophysiological patterns associated with migraine episodes, where the inner canthi and supraorbital temperatures drop significantly compared to normal conditions. These drops are likely due to vasoconstriction of the ophthalmic arteries under the inner canthi and sympathetic activation of the eccrine glands in the supraorbital region, respectively. The patterns were observed on eight migraine patients and meticulously quantified using advance computational methods, capable of delineating small anatomical structures in thermal imagery and tracking them automatically over time. Read More
Zhonghua Bing Li Xue Za Zhi 2018 Jul;47(7):536-541
Department of Pathology, the Affiliated Hospital of Qinghai University, Xining 810001, China.
To investigate the clinicopathologic features, immunophenotype, pathological diagnosis and treatment of malignant mixed tumor (MMT). Clinical and pathological features including immunohistochemical phenotypes were analyzed in a case of MMT accompanied with eccrine porocarcinoma (EP) involving both hands, diagnosed definitely in January 2018 along with review of relevant literature. A 64-year-old man presented with multiple rash on both hands for 4 years. Read More
Int J Dermatol 2018 Jul 11. Epub 2018 Jul 11.
Department of Dermatology, University of Florida College of Medicine, Gainesville, FL, USA.