16,003 results match your criteria Eating Disorder Anorexia


Vulnerability to psychological stress-induced anorexia in female mice depends on blockade of ghrelin signal in nucleus tractus solitarius.

Br J Pharmacol 2020 Aug 4. Epub 2020 Aug 4.

Pathophysiology and Therapeutics, Faculty of Pharmaceutical Sciences, Hokkaido University, Hokkaido, Japan.

Background And Purpose: Women are characterized by a higher incidence of eating disorders than men. We aimed to investigate whether the effects of ghrelin on feeding are essentially affected by sex and stress and to elucidate the biological factors that may cause sex differences in stress-mediated anorexia, focussing on the reactivity of ghrelin.

Experimental Approach: Acylated ghrelin was administered to naïve and psychologically stressed male and female C57BL/6J mice, followed by food intake and plasma hormone level measurements. Read More

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http://dx.doi.org/10.1111/bph.15219DOI Listing

Lifetime patterns of comorbidity in eating disorders: An approach using sequence analysis.

Eur Eat Disord Rev 2020 Aug 3. Epub 2020 Aug 3.

Brown School, Washington University in St. Louis, St. Louis, Missouri, USA.

Objective: Eating disorders (EDs) have high rates of psychiatric comorbidity. This study aimed to characterize longitudinal patterns of comorbidities in adults with EDs.

Methods: Sequence analysis and hierarchical clustering were applied to ages of onset and recency for select eating, substance, mood, and anxiety disorders from the 479 participants in the Collaborative Psychiatric Epidemiology Surveys with lifetime DSM-IV bulimia nervosa, binge eating disorder, or anorexia nervosa. Read More

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http://dx.doi.org/10.1002/erv.2767DOI Listing

Muscle dysmorphia: A systematic and meta-analytic review of the literature to assess diagnostic validity.

Int J Eat Disord 2020 Aug 1. Epub 2020 Aug 1.

Research School of Psychology, Australian National University, Canberra, Australia.

Objective: Although muscle dysmorphia (MD) is a new addition to DSM-5 as a specifier of body dysmorphic disorder (BDD), previous studies have treated MD as a stand-alone diagnosis. We aimed to assess the validity of MD as a stand-alone diagnosis via systematic and meta-analytic review of MD literature using both Robins and Guze criteria and additional criteria from Kendler.

Method: We performed a systematic search of ProQuest, PsycInfo, and PubMed databases for the period of January 1993 to October 2019 resulting in 40 papers to examine Robins and Guze's criteria (clinical picture) as well as those added by Kendler (antecedent validators; concurrent validators; predictive validators). Read More

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http://dx.doi.org/10.1002/eat.23349DOI Listing

Identifying research priorities for the study of atypical anorexia nervosa: A Delphi study.

Int J Eat Disord 2020 Jul 31:e23358. Epub 2020 Jul 31.

Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, & Stockholm Health Care Services, Stockholm, Sweden.

Objective: Individuals meeting all criteria for anorexia nervosa (AN) except that weight falls within or above the normal range despite significant weight loss are categorized as having atypical AN (AAN). Existing research has provided mixed evidence concerning the diagnostic demarcation of AN and AAN. The aim of the present study was to identify research priorities for furthering the understanding of AN and AAN as diagnostic entities. Read More

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http://dx.doi.org/10.1002/eat.23358DOI Listing

Therapist-guided smartphone-based aftercare for inpatients with severe anorexia nervosa (SMART-AN): Study protocol of a randomized controlled trial.

Int J Eat Disord 2020 Jul 31. Epub 2020 Jul 31.

Department of Psychiatry and Psychotherapy, University Hospital of Munich (LMU), Munich, Germany.

Objective: Inpatient treatment for patients with anorexia nervosa (AN) is recommended in extreme or severe cases after failure of outpatient treatment and is highly effective. However, a number of patients show symptom increase and relapse after discharge. The aim of this study is to evaluate the efficacy of a therapist-guided smartphone-based aftercare intervention for inpatients with AN to support symptom stabilization. Read More

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http://dx.doi.org/10.1002/eat.23357DOI Listing

Heterogeneity in Fear Processing across and within Anxiety, Eating, and Compulsive Disorders.

J Affect Disord 2020 Oct 22;275:329-338. Epub 2020 Jul 22.

Department of Psychiatry, Columbia University; New York State Psychiatric Institute.

Background: To assess within and across diagnosis variability we examined fear processing in healthy controls (HC) and three diagnostic groups that share symptoms of pathological anxiety: obsessive compulsive disorder (OCD); social anxiety disorder (SAD), and anorexia nervosa (AN).

Methods: Unmedicated adults (N=166) participated in a paradigm assessing associative fear acquisition, extinction, extinction recall, and fear renewal. Data were analyzed from two perspectives: comparison of each disorder to HC and exploratory latent class analysis (LCA) of the combined data. Read More

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http://dx.doi.org/10.1016/j.jad.2020.03.091DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7398449PMC
October 2020

Towards an Improved Understanding of the Anorexia Nervosa and Autism Spectrum Comorbidity: PEACE Pathway Implementation.

Front Psychiatry 2020 7;11:640. Epub 2020 Jul 7.

Northumbria Healthcare NHS Foundation Trust, Patient Experience Department, Wansbeck General Hospital, Ashington, United Kingdom.

This paper describes an eating disorder service development pilot project helping clinicians implement evidence-based research for patients with anorexia nervosa and autism spectrum condition comorbidity. Currently, there are no clear guidelines or recommendations for people who have the developmental condition of autism spectrum condition and a comorbid eating disorder. The Maudsley eating disorder team is pioneering a tailored approach of adaptations for this autism and eating disorder comorbidity to improve and adapt evidenced-based treatments and improve the experience for patients, families, and clinicians involved in their care. Read More

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http://dx.doi.org/10.3389/fpsyt.2020.00640DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7358367PMC

School Nurses on the Front Lines of Healthcare: Recognizing "BONES" and Knowing When to Pick Up the Phone: Eating Disorders Among Students in the School Setting.

NASN Sch Nurse 2020 Jul 30:1942602X20942531. Epub 2020 Jul 30.

Professor, Departments of Emergency Medicine and Pediatrics, Penn State College of Medicine, Attending Pediatric Emergency Medicine physician, Penn State Hershey Medical Center, Hershey, PA.

Through a case presentation, this article describes the assessment and management of a student presenting with a history of disordered eating and weight loss. As medical concerns are brought to the attention of the school nurse, it is important for the school nurse to be aware of common signs and symptoms seen in students with undiagnosed or established eating disorders, as well as possible medical complications associated with untreated or poorly controlled eating disorders. Possible signs and symptoms associated with eating disorders that require outpatient referral or emergent management is delineated in this article, and school nurses are provided with a helpful mnemonic called "BONES" to aid in the recognition of eating disorders in the school setting. Read More

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http://dx.doi.org/10.1177/1942602X20942531DOI Listing

The autism diagnostic observation schedule: Patterns in individuals with anorexia nervosa.

Eur Eat Disord Rev 2020 Jul 29. Epub 2020 Jul 29.

Section of Eating Disorders, Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.

Objective: Studies have used the Autism Diagnostic Observation Schedule (the ADOS-2) in individuals with anorexia nervosa (AN), but the patterns of scores have not been assessed. We examined which subset of the ADOS-2 items best discriminate individuals with AN from healthy controls (HC), and assessed the potential clustering of AN participants based on different profiles of the ADOS-2 item scores.

Method: We combined datasets from two previous studies, and (a) compared mean ranks between young AN participants (N = 118) and HC (N = 42), (ii) replicated the item selection procedure of the existing ADOS-2 algorithm to assess sensitivity of items in the AN group, and (c) applied a two-step clustering analysis in the AN group (N = 149). Read More

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http://dx.doi.org/10.1002/erv.2757DOI Listing

Early impact of COVID-19 on individuals with self-reported eating disorders: A survey of ~1,000 individuals in the United States and the Netherlands.

Int J Eat Disord 2020 Jul 28. Epub 2020 Jul 28.

Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.

Objective: We evaluated the early impact of COVID-19 on people with self-reported eating disorders.

Method: Participants in the United States (US, N = 511) and the Netherlands (NL, N = 510), recruited through ongoing studies and social media, completed an online survey that included both quantitative measures and free-text responses assessing the impact of COVID-19 on situational circumstances, eating disorder symptoms, eating disorder treatment, and general well-being.

Results: Results revealed strong and wide-ranging effects on eating disorder concerns and illness behaviors that were consistent with eating disorder type. Read More

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http://dx.doi.org/10.1002/eat.23353DOI Listing

Restrictive eating disorders in children and adolescents: a comparison between clinical and psychopathological profiles.

Eat Weight Disord 2020 Jul 27. Epub 2020 Jul 27.

Department of Neuroscience, Child Neuropsychiatry Unit, I.R.C.C.S. Bambino Gesù Children's Hospital, Rome, Italy.

Purpose: DSM-5 describe three forms of restrictive and selective eating: Anorexia Nervosa-Restrictive (AN-R), Anorexia Nervosa-Atypical (AN-A), and Avoidant/Restrictive Food Intake Disorder (ARFID). While AN is widely studied, the psychopathological differences among these three diseases are not clear. The aim of this study was to (i) compare the clinical features of AN-R, AN-A, and ARFID, in a clinical sample recruited from a specialized EDs program within a tertiary care children's Hospital; (ii) identifying three specific symptom profiles, to better understand if restrictive ED share a common psychopathological basis. Read More

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http://dx.doi.org/10.1007/s40519-020-00962-zDOI Listing

Telehealth transition in a comprehensive care unit for eating disorders: Challenges and long-term benefits.

Int J Eat Disord 2020 Jul 27. Epub 2020 Jul 27.

Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California, USA.

The 2019 novel coronavirus disease (COVID-19) pandemic has forced many eating disorder medical stabilization units to consider adjustments that uphold both the quality of care delivered to patients while also observing social distancing public health directives for patients and staff. To date, inpatient facilities for eating disorders (both medical stabilization units and higher level of care facilities) have not needed to consider how to translate services to electronic platforms, given that most of these programs have in-person staff. We outline our transition to telehealth broadly, emphasizing some unexpected benefits of using telehealth services that we plan on integrating into our work-flow post COVID-19. Read More

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http://dx.doi.org/10.1002/eat.23348DOI Listing

A tasting experiment comparing food and nutritional supplement in anorexia nervosa.

Appetite 2020 Jul 23:104789. Epub 2020 Jul 23.

Eating Disorders Center for Treatment and Research, Department of Neuroscience, University of Turin, Via Cherasco 11, 10126, Turin, Italy. Electronic address:

Anorexia nervosa (AN) is a severe psychiatric disorder leading to life-threatening emaciation. Weight restoration is crucial in treatment but few data are available on how to achieve it. Nutritional supplements are needed in treatment but patients' preferences about natural versus medical foods and their gustatory/hedonic perception are unclear. Read More

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http://dx.doi.org/10.1016/j.appet.2020.104789DOI Listing

A case report of a male patient receiving treatment for anorexia nervosa and comorbid obsessive compulsive disorder who was later diagnosed with nontuberculosis Mycobacterium.

Eat Weight Disord 2020 Jul 24. Epub 2020 Jul 24.

Adult Eating Disorders Program, Department of Adult Outpatient Psychiatry, Kingston Health Sciences Center, Hotel Dieu Hospital Site, 166 Brock Street, Kingston, Ontario, K7L5G2, Canada.

Cases of nontuberculous Mycobacterium (NTM) are on the rise across North America. This is the first clinical description of a 31-year old male patient in North America with Mycobacterium kansasii who met DSM-5 diagnostic criteria for anorexia nervosa (AN) and obsessive compulsive disorder (OCD), and who was engaged in specialized outpatient treatment of an eating disorder. The patient did not disclose at intake assessment that he was experiencing symptoms of a persistent cough, blood in his sputum, or that he was simultaneously being assessed outside of the eating disorders program for NTM until he had a positive smear for Mycobacterium kansasii in March 2017. Read More

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http://dx.doi.org/10.1007/s40519-020-00967-8DOI Listing

Repetitive transcranial magnetic stimulation treatment in severe, enduring anorexia nervosa: An open longer-term follow-up.

Eur Eat Disord Rev 2020 Jul 24. Epub 2020 Jul 24.

Section of Eating Disorders, Department of Psychological Medicine, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.

Objective: This study assessed longer-term outcomes from a randomised controlled feasibility trial of 20 sessions of real versus sham high-frequency repetitive transcranial magnetic stimulation (rTMS) to the left dorsolateral prefrontal cortex in adults with severe, enduring anorexia nervosa (SE-AN).

Methods: Thirty participants who completed the original study protocol were invited to take part in an open follow-up (18-months post-randomisation), assessing body mass index (BMI), eating disorder (ED) symptoms and other psychopathology.

Results: Twenty-four participants (12 each originally allocated to real/sham) completed the 18-month follow-up. Read More

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http://dx.doi.org/10.1002/erv.2766DOI Listing

Family-related non-abuse adverse life experiences occurring for adults diagnosed with eating disorders: a systematic review.

J Eat Disord 2020 22;8:36. Epub 2020 Jul 22.

School of Psychology, University College Dublin, Dublin, Ireland.

Background: Although previous reviews suggest a strong association between abuse and eating disorders, less is known about non-abuse adverse life experiences, such as parental mental illness or family discord, which occur frequently for this population. The aim of the current study was to identify family-related non-abuse adverse life experiences occurring for adults with eating disorders, and to establish whether they occur for people with anorexia nervosa, bulimia nervosa or binge-eating disorder more than the general population and other psychiatric populations.

Method: A systematic review of studies focusing on family-related non-abuse adverse life experiences and eating disorders was conducted in accordance with PRISMA guidelines. Read More

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http://dx.doi.org/10.1186/s40337-020-00311-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7374817PMC

Normotensive hypokalemic primary hyperaldosteronism mimicking clinical features of anorexia nervosa in a young patient: A case report.

Medicine (Baltimore) 2020 Jul;99(29):e20826

aDivision of General Medicine, Department of Internal Medicine bDivision of Nephrology, Department of Internal Medicine, Shin-Kong Wu Ho-Su Memorial Hospital cFu-Jen Catholic University School of Medicine, Taipei, Taiwan (ROC).

Rationale: The typical clinical presentations of patients with primary aldosteronism (PA) include generalized weakness, fatigue, high blood pressure, and potassium deficiency. However, normotensive PA is rare. Therefore, an atypical presentation of normal blood pressure is a challenge for the diagnosis and treatment of PA. Read More

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http://dx.doi.org/10.1097/MD.0000000000020826DOI Listing

[Trauma and anorexia nervosa: the association between trauma characteristics, PTSD and the duration of the eating disorder].

Tijdschr Psychiatr 2020 ;62(7):541-548

Background: Research into the prevalence of various traumatic events in anorexia nervosa (AN) is sparse, with the findings from these studies varying. In addition, the number and age at which traumatic events occurred was not consistently included in previous studies.
AIM: To study the prevalence of different types of traumatic events, whether they occurred in early childhood or not, the number of different events and their associations with PTSD symptoms, and the duration of the eating disorder among clinically admitted patients with AN. Read More

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January 2020

Dorsolateral prefrontal cortex and amygdala function during cognitive reappraisal predicts weight restoration and emotion regulation impairment in anorexia nervosa.

Psychol Med 2020 Jul 23:1-9. Epub 2020 Jul 23.

Ciber Fisiopatología Obesidad y Nutrición (CIBEROBN), Instituto Salud Carlos III, Barcelona, Spain.

Background: Although deficits in affective processing are a core component of anorexia nervosa (AN), we lack a detailed characterization of the neurobiological underpinnings of emotion regulation impairment in AN. Moreover, it remains unclear whether these neural correlates scale with clinical outcomes.

Methods: We investigated the neural correlates of negative emotion regulation in a sample of young women receiving day-hospital treatment for AN (n = 21) and healthy controls (n = 21). Read More

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http://dx.doi.org/10.1017/S0033291720002457DOI Listing

Why I recovered: A qualitative investigation of factors promoting motivation for eating disorder recovery.

Int J Eat Disord 2020 Aug 21;53(8):1244-1251. Epub 2020 Jul 21.

Department of Psychology, Harvard University, Cambridge, Massachusetts, USA.

Objective: It is difficult for individuals with eating disorders (EDs) to build and maintain motivation to recover. This challenge contributes to high rates of treatment dropout and relapse. To date, motivational interventions have been largely ineffective, and there is little research on factors that affect recovery motivation. Read More

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http://dx.doi.org/10.1002/eat.23331DOI Listing

Effectiveness of intensive cognitive behavioral therapy in adolescents and adults with anorexia nervosa.

Int J Eat Disord 2020 Jul 21. Epub 2020 Jul 21.

Department of Eating and Weight Disorders, Villa Garda Hospital, Garda (VR), Veneto, Italy.

Objective: This study aimed to compare the effectiveness of an intensive treatment based on enhanced cognitive behavioral therapy (CBT-E) in adolescent and adult patients with anorexia nervosa.

Methods: A total of 150 consecutive patients (74 adolescents and 81 adults) were admitted to a 20-week intensive CBT-E program (13 weeks of inpatient followed by 7 weeks of day-hospital treatment). All patients had responded poorly to previous outpatient treatments and were assessed at admission, end of treatment (EOT), and 20- and 60-week follow-ups. Read More

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http://dx.doi.org/10.1002/eat.23337DOI Listing

[Antidepressants sometimes lead to rapid remission in the treatment of anorexia nervosa].

Neuropsychopharmacol Hung 2020 Jun;22(2):72-76

Semmelweis Egyetem, Magatartástudományi Intézet, Budapest, Hungary.

In the treatment of anorexia nervosa the dominant role of psychotherapies is proposed, while pharmacotherapy has a limited effi cacy. Because of the broad comorbidity spectrum of the disorder, other psychiatric disorders are often present. Among them depression is frequent, so one of the selective theories of eating disorders stresses the importance of the relationship with depression. Read More

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Avoidant/restrictive food intake disorder symptoms are frequent in patients presenting for symptoms of gastroparesis.

Neurogastroenterol Motil 2020 Jul 16:e13931. Epub 2020 Jul 16.

Gastroenterology Division, Temple University Hospital, Philadelphia, Pennsylvania, USA.

Introduction: Patients with symptoms of gastroparesis/dyspepsia often avoid foods or restrict eating for symptom management. There is growing interest in understanding risk for feeding/eating disorders (FEDs) like avoidant/restrictive food intake disorder (ARFID). Among patients presenting with gastroparesis/dyspepsia symptoms, we aimed to determine: (a) FED symptom frequency, and (b) relation of FED symptoms to gastrointestinal symptom severity and gastric retention abnormalities. Read More

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http://dx.doi.org/10.1111/nmo.13931DOI Listing

"My Whole World Fell Apart": Parents Discovering Their Child Has Anorexia Nervosa.

Qual Health Res 2020 Jul 16:1049732320939508. Epub 2020 Jul 16.

University of Calgary, Calgary, Alberta, Canada.

This was the first study to examine the experience of parents who discover their child was living with anorexia nervosa (AN), thus fulfilling a critical gap in the eating disorder literature. Gadamerian hermeneutic inquiry was the guiding philosophy and method used to investigate this topic. Dialogues with parents revealed the ambiguity inherent within discovery; the isolation, betrayal, and loss felt by parents; and the complicated family dynamics occurring during the process of discovering one's child has AN. Read More

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http://dx.doi.org/10.1177/1049732320939508DOI Listing

Eating disorders and substance use at a South African tertiary hospital over a 21-year period.

S Afr J Psychiatr 2020 24;26:1421. Epub 2020 Jun 24.

Department of Psychiatry, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.

Background: Eating disorders (EDs) and substance-related disorders pose a challenge when they co-occur and have implications for patient management. Clinical information on EDs and substance-related disorders as independent disorders is fairly well established in South Africa, but our understanding of the coexistence of these disorders is limited.

Aim: To determine the prevalence, the concurrent nature and the possible trends of substance use among patients diagnosed with EDs at a South African tertiary hospital over a 21-year period. Read More

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http://dx.doi.org/10.4102/sajpsychiatry.v26i0.1421DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7343936PMC

Heightened affective response to perturbation of respiratory but not pain signals in eating, mood, and anxiety disorders.

PLoS One 2020 15;15(7):e0235346. Epub 2020 Jul 15.

Laureate Institute for Brain Research, Tulsa, OK, United States of America.

Several studies have recently suggested that an abnormal processing of respiratory interoceptive and nociceptive (painful) stimuli may contribute to eating disorder (ED) pathophysiology. Mood and anxiety disorders (MA) are also characterized by abnormal respiratory symptoms, and show substantial comorbidity with ED. However, no studies have examined both respiratory and pain processing simultaneously within ED and MA. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0235346PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7363095PMC

Self-admission to inpatient treatment in anorexia nervosa: Impact on healthcare utilization, eating disorder morbidity, and quality of life.

Int J Eat Disord 2020 Jul 15. Epub 2020 Jul 15.

Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, & Stockholm Health Care Services, Stockholm County Council, Stockholm, Sweden.

Objective: Little evidence exists concerning the optimal model of inpatient care for patients with longstanding anorexia nervosa (AN). Self-admission has been developed as a treatment tool whereby patients with a history of high healthcare utilization are invited to decide for themselves when brief admission is warranted. The aim of this study was to evaluate the impact of a self-admission program on healthcare utilization, eating disorder morbidity, health-related quality of life (HRQoL), and sick leave for patients with AN. Read More

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http://dx.doi.org/10.1002/eat.23346DOI Listing

Perceptions of genetic risk, testing, and counseling among individuals with eating disorders.

Int J Eat Disord 2020 Jul 15. Epub 2020 Jul 15.

Departments of Psychiatry and Medical Genetics, BC Mental Health and Substance Use Services Research Institute, University of British Columbia, Vancouver, British Columbia, Canada.

Objective: Eating disorders develop as a result of genetic and environmental factors. Given that they are multifactorial conditions with a genetic component, they fall within the scope of practice for genetic counseling, but people with these conditions are rarely referred. The purpose of this study was to explore the perceptions of causes of eating disorders, recurrence risk, and interest in genetic counseling and testing among individuals with eating disorders. Read More

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http://dx.doi.org/10.1002/eat.23333DOI Listing

Age dependency of body mass index distribution in childhood and adolescent inpatients with anorexia nervosa with a focus on DSM-5 and ICD-11 weight criteria and severity specifiers.

Eur Child Adolesc Psychiatry 2020 Jul 14. Epub 2020 Jul 14.

Department of Child and Adolescent Psychiatry, Psychotherapy and Psychosomatics, University Hospital Essen (AöR), University of Duisburg-Essen, Wickenburgstrasse 21, 45147, Essen, Germany.

Both DSM-5 and ICD-11 have provided weight cut-offs and severity specifiers for the diagnosis of anorexia nervosa (AN) in childhood, adolescence and adulthood. The aims of the current study focusing on inpatients aged < 19 years were to assess (1) the relationship between age and body mass index (BMI; kg/m), BMI-centiles, BMI-standard deviation scores (BMI-SDS) and body height-SDS at referral, (2) the percentages of patients fulfilling the DSM-5 and ICD-11 weight criteria and severity categories for AN, and (3) the validity of the AN severity specifiers via analysis of both weight related data at discharge and inpatient treatment duration. The German Registry for Anorexia Nervosa encompassed complete data sets for 469 female patients (mean age = 15. Read More

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http://dx.doi.org/10.1007/s00787-020-01595-4DOI Listing

Early predictors of treatment outcome in a partial hospital program for adolescent anorexia nervosa.

Int J Eat Disord 2020 Jul 14. Epub 2020 Jul 14.

Department of Psychiatry, University of California, San Diego, La Jolla, California, USA.

Objective: Previous research supports the relevance of early symptom change in eating disorder (ED) treatment; however, few studies have distinguished early weight change from early change in ED psychopathology, particularly in higher levels of care. Thus, the present study examined whether early change in weight and ED psychopathology predicted outcome for adolescents with anorexia nervosa (AN) in a partial hospitalization program.

Method: Adolescents with AN (n = 99) completed assessments at admission, 1-month after treatment admission, discharge, and 6-month follow-up. Read More

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http://dx.doi.org/10.1002/eat.23343DOI Listing

Molecular neuroanatomy of anorexia nervosa.

Sci Rep 2020 Jul 10;10(1):11411. Epub 2020 Jul 10.

Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Canada.

Anorexia nervosa is a complex eating disorder with genetic, metabolic, and psychosocial underpinnings. Using genome-wide methods, recent studies have associated many genes with the disorder. We characterized these genes by projecting them into reference transcriptomic atlases of the prenatal and adult human brain to determine where these genes are expressed in fine detail. Read More

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http://dx.doi.org/10.1038/s41598-020-67692-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7351758PMC

The Freiburg sport therapy program for eating disorders: a randomized controlled trial.

J Eat Disord 2020 7;8:31. Epub 2020 Jul 7.

Department of Psychosomatic Medicine und Psychotherapy, Center for Mental Health, Faculty of Medicine, University of Freiburg, Hauptstraße 8, D-79104 Freiburg, Germany.

Background: Unhealthy attitudes towards sport and problematic exercise behavior in eating disorders (ED) are common and associated with poorer treatment outcome and higher relapse rates. There is a need to develop and empirically test interventions that could complement standard treatment. The study aimed to assess the efficacy of the Freiburg sport therapy program for eating disorders (FSTP). Read More

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http://dx.doi.org/10.1186/s40337-020-00309-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7339379PMC

Exploring the ways in which COVID-19 and lockdown has affected the lives of adult patients with anorexia nervosa and their carers.

Eur Eat Disord Rev 2020 Jul 9. Epub 2020 Jul 9.

Institute of Psychiatry, Psychology and Neuroscience, Department of Psychological Medicine, Section of Eating Disorders, King's College London, London, UK.

Objective: This qualitative study explores the ways in which the coronavirus disease 2019 (COVID-19) pandemic and associated lockdown measures have affected the lives of adult patients with anorexia nervosa (AN) and their carers.

Method: Semi-structured interviews were conducted with patients with AN (n = 21) and carers (n = 28) from the start of UK Government imposed lockdown. Data related directly to the impact of lockdown and COVID-19 were analysed using thematic analysis. Read More

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http://dx.doi.org/10.1002/erv.2762DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7362064PMC

Multi-method assessment of palatable food exposure in women with and without eating disorders.

Eur Eat Disord Rev 2020 Jul 6. Epub 2020 Jul 6.

TEDp (Temple Eating Disorders Program), Temple University, 1701 North 13th Street, Philadelphia, Pennsylvania, 19122, USA.

Objective: Eating disorders (EDs) are characterized by dysregulated responses to palatable food. Using a multi-method approach, this study examined responses to palatable food exposure and subsequent ad libitum eating in women with binge-eating disorder (BED: n = 64), anorexia nervosa (AN: n = 16), and bulimia nervosa (BN: n = 35) and 26 healthy controls (HCs).

Method: Participants were exposed to palatable food followed by an ad libitum eating opportunity. Read More

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http://dx.doi.org/10.1002/erv.2746DOI Listing

Personality correlates of eating pathology severity and subtypes in The National Comorbidity Survey Adolescent Supplement.

J Clin Psychol 2020 Jul 6. Epub 2020 Jul 6.

Department of Psychology, University of Victoria, Victoria, British Columbia, Canada.

Objective: We examined how personality traits are associated with eating pathology (EP) across a range of severities and symptom subtypes.

Method: The National Comorbidity Survey Adolescent Supplement (N = 10,148) was used to compare personality across severities (i.e. Read More

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http://dx.doi.org/10.1002/jclp.23021DOI Listing

Peer mentoring for individuals with an eating disorder: a qualitative evaluation of a pilot program.

J Eat Disord 2020 1;8:29. Epub 2020 Jul 1.

School of Behavioural and Health Science, Australian Catholic University, Melbourne, VIC Australia.

Background: After receiving intensive medical treatment; individuals with eating disorders often require ongoing care to maintain their recovery, build social networks, and reduce risk of relapse.

Methods: To address this important transition period, a six-month peer mentoring program was developed and piloted in Melbourne, Australia. Twelve adults with a past history of an eating disorder (mentors) were paired with 14 individuals with a current eating disorder (mentees). Read More

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http://dx.doi.org/10.1186/s40337-020-00301-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7329554PMC

Evidence-based treatments remain the best intervention for good long-term outcome of severe and enduring anorexia nervosa.

Int J Eat Disord 2020 Aug 4;53(8):1322-1323. Epub 2020 Jul 4.

School of Psychology, Speech and Hearing, University of Canterbury, Christchurch, New Zealand.

More research is needed about response to specialist treatments for severe and enduring anorexia nervosa. Current evidence suggests those with severe and enduring anorexia nervosa respond to evidence-based treatments and continue to recover over decades. In the absence of clear guidelines to the contrary and given our understanding of the superior efficacy of specialist treatments over more eclectic treatment choices, it is our responsibility to continue to train and supervise clinicians to deliver evidence-based treatments, irrespective of the variant of anorexia nervosa. Read More

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http://dx.doi.org/10.1002/eat.23325DOI Listing

COVID-19, Substance Use, Anorexia Nervosa, 22q11.2 Deletion Syndrome, and Stress.

Authors:
Ned H Kalin

Am J Psychiatry 2020 07;177(7):561-563

Department of Psychiatry, University of Wisconsin School of Medicine and Public Health, Madison.

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http://dx.doi.org/10.1176/appi.ajp.2020.20050685DOI Listing

Food Addiction among Female Patients Seeking Treatment for an Eating Disorder: Prevalence and Associated Factors.

Nutrients 2020 Jun 26;12(6). Epub 2020 Jun 26.

Addictology and Psychiatry Department, Hôpital Saint Jacques, University Hospital of Nantes, 85 rue Saint Jacques, CEDEX 1, 44 093 Nantes, France.

The concept of "food addiction" (FA) has aroused much focus because of evidence for similarities between overeating and substance use disorders (SUDs). However, few studies have explored this concept among the broad spectrum of eating disorders (ED), especially in anorexia nervosa (AN). This study aimed to assess FA prevalence in ED female patients and to determine its associated factors. Read More

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http://dx.doi.org/10.3390/nu12061897DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7353200PMC

Visual attention to food cues and the course of anorexia nervosa.

Behav Res Ther 2020 May 30;132:103649. Epub 2020 May 30.

University of Groningen, Department of Clinical Psychology and Experimental Psychopathology, the Netherlands.

Previously, adolescents with anorexia nervosa (AN) showed reduced attentional engagement with food cues compared to adolescents without eating disorder (Jonker, Glashouwer, Hoekzema, Ostafin, & De Jong, 2019). This study tested whether (i) improvement in eating disorder symptoms and BMI are related to an increase in attentional engagement with food, and whether (ii) relatively low attentional engagement is related to persistent AN symptomatology, in the same sample of adolescents with AN (N = 69) from the study of Jonker et al. (2019). Read More

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http://dx.doi.org/10.1016/j.brat.2020.103649DOI Listing

Review of Randomized Controlled Trials Using e-Health Interventions for Patients With Eating Disorders.

Front Psychiatry 2020 12;11:568. Epub 2020 Jun 12.

Eating Disorders Unit, Toronto General Hospital, University Health Network, Toronto, ON, Canada.

Background: In a world of technological advancements, electronic devices and services seem to be a promising way to increase patients' engagement in treatment and to help manage their symptoms. Here, we identified and analyzed the current evidence of RCTs to evaluate the effectiveness and acceptability of e-health interventions in the eating disorder (ED) field.

Methods: We screened an initial cluster of 581 papers. Read More

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http://dx.doi.org/10.3389/fpsyt.2020.00568DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7304304PMC

A Case of Gitelman Syndrome Diagnosed with Anorexia Nervosa in a Psychiatry Clinic.

Turk Psikiyatri Derg 2020 ;31(1):69-73

Anorexia nervosa is a disorder that is characterized by excessive preoccupation with body weight and shape, and conscious attempts to stay in low weight due to fear of weight gain. Vomiting, one of the METHODS used by anorexia nervosa patients to stay in low weight, is one of the most important causes of hypokalemia. Diuretics and diarrhea are other common causes of hypokalemia. Read More

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January 2020

Attachment Security and Perceived Expressed Emotion in Adolescents with Anorexia Nervosa.

Turk Psikiyatri Derg 2020 ;31(1):22-30

Objective: The aim of this study was to compare the attachment security and perceived expressed emotion of female adolescents diagnosed with anorexia nervosa and those without any psychiatric disorder and to compare the expressed emotion of their parents. We also aimed to investigate the relationships between these variables and the effects of depression and anxiety symptoms of the adolescents on attachment security, perceived expressed emotion and expressed emotion of the parents.

Method: The study enrolled 43 female adolescents aged 12-18 years diagnosed with anorexia nervosa and an age and economic statusmatched control group of 37 healthy female adolescents. Read More

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January 2020

Anorexia nervosa in adolescents.

Br J Hosp Med (Lond) 2020 Jun 1;81(6):1-8. Epub 2020 Jun 1.

UCL Great Ormond Street Institute of Child Health, London, UK.

Anorexia nervosa is an eating disorder with peak onset in adolescence, which carries the highest mortality rate of all psychiatric illnesses. It is commonly comorbid with other physical and mental health problems, yet training on management of people with eating disorders and working knowledge of clinicians working with underweight adolescents is inconsistent. This review of anorexia nervosa in adolescents provides an overview of the presentation, aetiology and treatment of this disorder, with a particular focus on the assessment and management of physical health risks, including refeeding syndrome. Read More

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http://dx.doi.org/10.12968/hmed.2020.0099DOI Listing

Nursing assistants' experiences of administering manual restraint for compulsory nasogastric feeding of young persons with anorexia nervosa.

Int J Ment Health Nurs 2020 Jun 24. Epub 2020 Jun 24.

School of Social Sciences, Psychology, University of Westminster, London, UK.

Manual restraint, a type of physical restraint, is a common practice in inpatient mental health settings linked to adverse physical and psychological staff and patient outcomes. However, little is known about the use of manual restraint for compulsory nasogastric feeding of patients with anorexia nervosa within inpatient eating disorder settings. The present phenomenological study aimed to explore nursing assistants' experiences of administering manual restraint for compulsory nasogastric feeding of young persons with anorexia nervosa. Read More

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http://dx.doi.org/10.1111/inm.12758DOI Listing

Duration of untreated eating disorder and relationship to outcomes: A systematic review of the literature.

Eur Eat Disord Rev 2020 Jun 23. Epub 2020 Jun 23.

Section of Eating Disorder, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.

Objective: This systematic review assesses the average duration of untreated eating disorder (DUED) in help-seeking populations at the time of first eating disorder (ED) treatment and investigates the relationship between DUED and symptom severity/clinical outcomes.

Method: PRISMA guidelines were followed throughout. Selected studies provided information on either: (i) length of DUED, (ii) components of DUED, (iii) cross-sectional associations between DUED and symptom severity, (iv) associations between DUED and clinical outcomes, or (v) experimental manipulation of DUED. Read More

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http://dx.doi.org/10.1002/erv.2745DOI Listing

Applying epigenetic science to the understanding of eating disorders: a promising paradigm for research and practice.

Curr Opin Psychiatry 2020 Jun 22. Epub 2020 Jun 22.

Department of Psychiatry, McGill University.

Purpose Of Review: Studies indicate that environmental factors, acting at various moments throughout the life cycle, can result in epigenetically mediated alterations in gene expression. In this article, we review recent findings on the role of epigenetic factors in eating disorders, address methodological issues that need to be considered when interpreting research findings, and comment on possible clinical applications.

Recent Findings: Evidence suggests that eating disorders implicate alterations of methylation in genes involved in the mental status, metabolism, anthropometric features and immunity. Read More

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http://dx.doi.org/10.1097/YCO.0000000000000632DOI Listing

Health in adulthood after severe anorexia nervosa in adolescence: a study of exposed and unexposed women.

Eat Weight Disord 2020 Jun 23. Epub 2020 Jun 23.

Université Paris-Saclay, Univ. Paris-Sud, UVSQ, CESP, INSERM, Paris, France.

Objective: To compare the global health status, frequency of somatic and psychological problems, and alcohol use in adulthood among women hospitalized in adolescence for severe anorexia nervosa (AN), with a matched control sample from the general population.

Method: Women (n = 86) who had been hospitalized for AN 9.31 ± 1. Read More

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http://dx.doi.org/10.1007/s40519-020-00940-5DOI Listing

Eye blink and reward prediction error response in anorexia nervosa.

Int J Eat Disord 2020 Jun 22. Epub 2020 Jun 22.

Department of Psychiatry, University of California at San Diego, San Diego, California, USA.

Background: Functional brain imaging has been used to study brain reward function and behavioral traits in anorexia nervosa (AN). Here we tested whether eye blink relates to behavior and brain imaging response as a method that is less costly and more accessible.

Method: We recruited 26 women with AN and 50 healthy matched controls. Read More

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http://dx.doi.org/10.1002/eat.23332DOI Listing