544 results match your criteria Early Symptomatic HIV Infection


Differences in Cervical Cancer Screening Knowledge and Practices by HIV Status and Geographic Location: Implication for Program Implementation in Zambia.

Afr J Reprod Health 2018 Dec;22(4):92-101

Research Triangle Institute.

The knowledge and perceptions of cervical cancer among HIV negative and positive women, aged 25-49 years, from rural and urban locations in Zambia was systematically accessed in this study to determine any differences. Data were coded and analyzed using NVivo software. Compared to HIV negative women, HIV positive women had more accurate information about cervical cancer. Read More

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http://dx.doi.org/10.29063/ajrh2018/v22i4.10DOI Listing
December 2018
4 Reads

Serum Levels of Soluble CD40 Ligand and Neopterin in HIV Coinfected Asymptomatic and Symptomatic Visceral Leishmaniasis Patients.

Front Cell Infect Microbiol 2018 11;8:428. Epub 2018 Dec 11.

Unit of NTDs, Department of Clinical Sciences, Institute of Tropical Medicine, Antwerp, Belgium.

Human Immunodeficiency Virus (HIV) co-infection drastically increases the risk of developing overt visceral leishmaniasis (VL). The asymptomatic infection window constitutes an opportunity to identify those HIV patients at highest risk by defining early markers associated with disease susceptibility or resistance. As intracellular parasite killing is essential, we investigated whether serum markers of macrophage activation were notably affected in HIV patients with an asymptomatic infection or overt visceral leishmaniasis disease. Read More

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https://www.frontiersin.org/article/10.3389/fcimb.2018.00428
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http://dx.doi.org/10.3389/fcimb.2018.00428DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6297181PMC
December 2018
7 Reads

Metabolite changes in blood predict the onset of tuberculosis.

Nat Commun 2018 12 6;9(1):5208. Epub 2018 Dec 6.

Max Planck Institute for Infection Biology, 10117, Berlin, Germany.

New biomarkers of tuberculosis (TB) risk and disease are critical for the urgently needed control of the ongoing TB pandemic. In a prospective multisite study across Subsaharan Africa, we analyzed metabolic profiles in serum and plasma from HIV-negative, TB-exposed individuals who either progressed to TB 3-24 months post-exposure (progressors) or remained healthy (controls). We generated a trans-African metabolic biosignature for TB, which identifies future progressors both on blinded test samples and in external data sets and shows a performance of 69% sensitivity at 75% specificity in samples within 5 months of diagnosis. Read More

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http://dx.doi.org/10.1038/s41467-018-07635-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6283869PMC
December 2018
5 Reads

A Clinico-epidemiological Study of Childhood Herpes Zoster.

Indian Dermatol Online J 2018 Nov-Dec;9(6):383-388

Department of Dermatology, Military Hospital, Bareilly, Uttar Pradesh, India.

Herpes zoster (HZ) is a viral infection believed to be caused by the re activation of varicella zoster virus (VZV) or human herpes virus type 3 (HHV 3) that persists in the posterior nerve root ganglion. HZ is rarely reported in the pediatric age group with an intact immunity. Past infection with VZV and immunization with chickenpox vaccine are key markers in the onset of varicella zoster in children. Read More

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http://dx.doi.org/10.4103/idoj.IDOJ_107_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6232977PMC
December 2018
5 Reads

Neonatal and infant diagnostic HIV-PCR uptake and associations during three sequential policy periods in Cape Town, South Africa: a longitudinal analysis.

J Int AIDS Soc 2018 Nov;21(11):e25212

Centre for Infectious Disease Epidemiology & Research, School of Public Health & Family Medicine, University of Cape Town, Cape Town, South Africa.

Introduction: To strengthen the early infant diagnosis (EID) programmes and timeously identify and treat HIV-infected infants, birth HIV-PCR for some/all infants has been recommended in the Western Cape, South Africa since 2014. Operational data on the implementation of such programmes in low- and middle-income countries are limited.

Methods: Utilizing the electronic records platform at primary care facilities, we developed an electronic register which consolidated obstetric and HIV-related data, allowing us to track a cohort of HIV-infected/exposed mother/infant dyads longitudinally from antenatal care through delivery to infant HIV-PCR. Read More

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http://dx.doi.org/10.1002/jia2.25212DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6256843PMC
November 2018
11 Reads

Symptomatic cryptococcal antigenemia presenting as early cryptococcal meningitis with negative CSF analysis.

Clin Infect Dis 2018 09 25. Epub 2018 Sep 25.

Infectious Diseases Institute, College of Health Sciences, Makerere University, Kampala, Uganda.

Background: Individuals with cryptococcal antigenemia are at high risk of developing cryptococcal meningitis if untreated. The progression and timing from asymptomatic infection to cryptococcal meningitis is unclear. We describe a sub-population of individuals with neurologic symptomatic cryptococcal antigenemia, but negative CSF studies. Read More

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https://academic.oup.com/cid/advance-article/doi/10.1093/cid
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http://dx.doi.org/10.1093/cid/ciy817DOI Listing
September 2018
5 Reads
8.890 Impact Factor

Is early HIV infection diagnosis at a reference center a reality in the state of Ceara?

Rev Soc Bras Med Trop 2018 Jul-Aug;51(4):518-522

Centro de Pesquisa, Universidade de Fortaleza, Fortaleza, CE, Brasil.

Introduction: Early diagnosis of human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) can decrease transmission and significantly affect morbidity and mortality; however, Brazil still confronts the reality of late HIV diagnosis.

Methods: Medical records of 284 HIV-positive patients were reviewed in this cross-sectional study.

Results: Of all patients, 28% were diagnosed in the context of health assessments, whereas 27% were symptomatic at diagnosis. Read More

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http://dx.doi.org/10.1590/0037-8682-0393-2017DOI Listing
September 2018

Immune-checkpoint inhibitors in non-small cell lung cancer: A tool to improve patients' selection.

Crit Rev Oncol Hematol 2018 Sep 23;129:27-39. Epub 2018 Jun 23.

Medical Oncology Unit, San Gerardo Hospital, Monza, Italy.

The identification of reliable predictive biomarkers of efficacy or resistance to immune-oncology (I-O) agents is a major issue for translational research and clinical practice. However, along with PDL1 and molecular features other clinical, radiological and laboratory factors can be considered for the selection of those patients who would not be the best candidate for immune-checkpoint inhibitors (ICPIs). We examined these factors, emerging from the results of currently available studies in non-small cell lung cancer (NSCLC), aiming to provide a useful and manageable tool which can help Oncologists in their everyday clinical practice. Read More

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http://dx.doi.org/10.1016/j.critrevonc.2018.06.016DOI Listing
September 2018
12 Reads

Neuropsychiatric manifestations among HIV-1 infected African patients receiving efavirenz-based cART with or without tuberculosis treatment containing rifampicin.

Eur J Clin Pharmacol 2018 Jul 12. Epub 2018 Jul 12.

Division of Clinical Pharmacology, Department of Laboratory Medicine, Karolinska University Hospital-Huddinge, Karolinska Institute, Stockholm, Sweden.

Purpose: Efavirenz-based combination antiretroviral therapy (cART) is associated with neuropsychiatric adverse events. We investigated the time to onset, duration, clinical implications, impact of pharmacogenetic variations, and anti-tuberculosis co-treatment on efavirenz-associated neuropsychiatric manifestations.

Methods: Prospective cohort study of cART naïve HIV patients with or without tuberculosis (HIV-TB) co-infection treated with efavirenz-based cART. Read More

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http://dx.doi.org/10.1007/s00228-018-2499-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6182598PMC
July 2018
1 Read

Family Testing: An Index Case Finding Strategy to Close the Gaps in Pediatric HIV Diagnosis.

J Acquir Immune Defic Syndr 2018 Aug;78 Suppl 2:S88-S97

Baylor College of Medicine Children's Foundation Malawi, Lilongwe, Malawi.

Despite significant advances in pediatric HIV treatment, too many children remain undiagnosed and thus without access to lifesaving antiretroviral therapy. It is critical to identify these children and initiate antiretroviral therapy as early as possible. Although the children of HIV-infected adults are at higher risk of infection, few access HIV testing services because of missed opportunities in existing case finding programs. Read More

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http://dx.doi.org/10.1097/QAI.0000000000001731DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6047763PMC
August 2018
33 Reads

The diagnosis of symptomatic acute antiretroviral syndrome during the window period with antigen/antibody testing and HIV viral load.

Authors:
Daniel O Griffin

IDCases 2018 25;12:157-160. Epub 2018 May 25.

Columbia University Medical Center, Department of Biochemistry and Molecular Biophysics, Department of Medicine-Division of Infectious Diseases, New York, NY 10032, United States.

Despite much focus on moving toward a cure to end the epidemic human immunodeficiency virus (HIV) epidemic there are still thousands of new infections occurring every year in the United States. Although there is ongoing transmission of HIV in the United States and a growing population of people living with HIV, the acute presentation of HIV infection can be challenging to diagnose and is often not considered when patients present to healthcare providers. Although in certain states there are HIV testing laws that require that all persons between the ages of 13 and 64 be offered HIV testing in an opt-out approach, many patient presenting with an acute illness, that would warrant diagnostic testing for HIV, leave without having an HIV test performed for either diagnostic or screening purposes. Read More

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http://dx.doi.org/10.1016/j.idcr.2018.05.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6011141PMC
May 2018
5 Reads

A randomised trial of a contraceptive vaginal ring in women at risk of HIV infection in Rwanda: Safety of intermittent and continuous use.

PLoS One 2018 1;13(6):e0197572. Epub 2018 Jun 1.

Department of Clinical Infection, Microbiology and Immunology, Institute of Infection and Global Health, University of Liverpool, Liverpool, United Kingdom.

Background: Contraceptive vaginal rings could play a role in expanding the contraceptive method mix and in preparing communities for the introduction of HIV prevention and multipurpose rings.

Methods: We conducted an open label single-centre randomised clinical trial of intermittent versus continuous use of NuvaRing® in Kigali, Rwanda, in 2013-2014. We randomised 120 HIV-negative women 1:1 to intermittent use (three rings with a ring-free week in between rings) or continuous use (four rings without ring-free weeks). Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0197572PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5983532PMC
December 2018
7 Reads

"I was referred from the other side": Gender and HIV testing among older South Africans living with HIV.

PLoS One 2018 23;13(4):e0196158. Epub 2018 Apr 23.

School of Public Health, University of Western Cape, Bellville, South Africa.

South Africa has a Universal Test and Treat (UTT) policy in place to ensure that everyone tests for HIV and can access treatment if they test positive. The aim of this study is to document the pathways that older South Africans who are living with HIV take to access testing and treatment in this context. Despite the aging of the HIV epidemic in South Africa and clear evidence that testing older persons (over age 50) is necessary, very little is known about the circumstances under which older persons test for HIV or their motivations for doing so. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0196158PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5912735PMC
July 2018
4 Reads

Utility of antitreponemal IgM testing in the diagnosis of early and repeat syphilis among HIV-infected and non-infected patients.

Int J STD AIDS 2018 08 8;29(9):890-894. Epub 2018 Apr 8.

1 Department of Dermatology, Faculty of Medicine, Jagiellonian University Medical College, Cracow, Poland.

Until now only non-treponemal tests (e.g. rapid plasma reagin [RPR]) have been used to monitor syphilis activity (e. Read More

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http://dx.doi.org/10.1177/0956462418762849DOI Listing
August 2018
6 Reads

Neurologic sequelae of primary HIV infection.

Handb Clin Neurol 2018 ;152:65-74

Department of Neurology, St. Vincent's Hospital, Sydney, NSW, Australia.

Primary human immunodeficiency virus type 1 (HIV-1) infection is defined as the period from initial infection with HIV to complete seroconversion. Neurologic sequelae of primary HIV-1 infection are not uncommon, potentially affecting all parts of the nervous system. It is important for the neurologist to be aware of symptomatic primary HIV infection, as it may afford an early and accurate diagnosis of HIV infection and the opportunity for consideration of early antiretroviral therapy. Read More

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http://dx.doi.org/10.1016/B978-0-444-63849-6.00006-2DOI Listing
September 2018
2 Reads

Clinical features of acute human immunodeficiency virus infection in Taiwan: A multicenter study.

J Microbiol Immunol Infect 2018 Mar 2. Epub 2018 Mar 2.

Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, ROC. Electronic address:

Background/purpose: Acute HIV infection is characterized by a high concentration of HIV RNA in the plasma and rapid depletion of the CD4 cell count. This multicenter, retrospective observational study aimed to characterize the manifestations of acuteHIV infection in Taiwan.

Methods: Between 1 January 2012 and 31 December 2016, all patients aged 20 years or greater who presented with acute HIV infection were included. Read More

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http://dx.doi.org/10.1016/j.jmii.2018.01.005DOI Listing
March 2018
14 Reads

Priorities for Decreasing Morbidity and Mortality in Children With Advanced HIV Disease.

Clin Infect Dis 2018 Mar;66(suppl_2):S147-S151

HIV Department, World Health Organization, Geneva, Switzerland.

Early mortality and morbidity remain high in children initiating antiretroviral therapy (ART), especially in sub-Saharan Africa. Many children still present with advanced human immunodeficiency virus (HIV) disease. Tuberculosis, pneumonia, and severe bacterial infections are the main causes of hospital admission in HIV-infected children. Read More

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http://dx.doi.org/10.1093/cid/ciy013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5850631PMC
March 2018
2 Reads

Trends in adult chlamydia and gonorrhoea prevalence, incidence and urethral discharge case reporting in Mongolia from 1995 to 2016 - estimates using the Spectrum-STI model.

Western Pac Surveill Response J 2017 Oct-Dec;8(4):20-29. Epub 2017 Dec 1.

Avenir Health, Geneva, Switzerland.

Objective: To estimate Mongolia's prevalence and incidence trends of gonorrhoea and chlamydia in women and men 15-49 years old to inform control of STIs and HIV, a national health sector priority.

Methods: We applied the Spectrum-STI estimation model, fitting data from two national population surveys (2001 and 2008) and from routine gonorrhoea screening of pregnant women in antenatal care (1997 to 2016) adjusted for diagnostic test performance, male/female differences and missing high-risk populations. Prevalence and incidence estimates were then used to assess completeness of national case reporting. Read More

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http://dx.doi.org/10.5365/wpsar.2017.8.2.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5803554PMC
May 2018
3 Reads
2 Citations

Human Immunodeficiency Virus in the Brain-Culprit or Facilitator?

Authors:
Luminita Ene

Infect Dis (Auckl) 2018 14;11:1178633717752687. Epub 2018 Feb 14.

HIV Department, "Dr. Victor Babes" Hospital for Infectious and Tropical Diseases, Bucharest, Romania.

Introduction: Human immunodeficiency virus (HIV) enters the brain early, where it can persist, evolve, and become compartmentalized. Central nervous system (CNS) disease can be attributed to HIV alone or to the complex interplay between the virus and other neurotropic pathogens.

Aim: The current review aims to describe the direct impact of HIV on the brain as well as its relationship with other pathogens from a practitioner's perspective, to provide a general clinical overview, brief workup, and, whenever possible, treatment guidance. Read More

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http://dx.doi.org/10.1177/1178633717752687DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5815409PMC
February 2018

Favourable outcome in a child with symptomatic diagnosis of Glutaric aciduria type 1 despite vertical HIV infection and minor head trauma.

Metab Brain Dis 2018 04 9;33(2):537-544. Epub 2018 Feb 9.

Family Clinical Research Unit, Department of Paediatrics and Child Health, Tygerberg Hospital and Stellenbosch University, Francie van Zijl Drive, Tygerberg, Cape Town, South Africa.

The first case of Glutaric aciduria Type 1(GA1) in an African child was reported in 2001. GA1 has a prevalence of 1:5000 in black South Africans. Although early diagnosis is essential for a favourable outcome, newborn screening is not routine in South Africa where an estimated 320,000 children have HIV infection. Read More

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http://dx.doi.org/10.1007/s11011-018-0196-4DOI Listing
April 2018
3 Reads

HIV-Associated Cryptococcal Disease in Resource-Limited Settings: A Case for "Prevention Is Better Than Cure"?

J Fungi (Basel) 2017 Dec 2;3(4). Epub 2017 Dec 2.

Division of Infection, Immunity and Respiratory Medicine, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester M13 9PL, UK.

Cryptococcal disease remains a significant source of global morbidity and mortality for people living with HIV, especially in resource-limited settings. The recently updated estimate of cryptococcal disease revealed a global incidence of 223,100 cases annually with 73% of these cases being diagnosed in sub-Saharan Africa. Furthermore, 75% of the estimated 181,100 deaths associated with cryptococcal disease occur in sub-Saharan Africa. Read More

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http://dx.doi.org/10.3390/jof3040067DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5753169PMC
December 2017
3 Reads

Implementing universal HIV treatment in a high HIV prevalence and rural South African setting - Field experiences and recommendations of health care providers.

PLoS One 2017 20;12(11):e0186883. Epub 2017 Nov 20.

Univ. Bordeaux, Inserm, Bordeaux Population Health Research Center, UMR 1219, Bordeaux, France.

Background: We aimed to describe the field experiences and recommendations of clinic-based health care providers (HCP) regarding the implementation of universal antiretroviral therapy (ART) in rural KwaZulu-Natal, South Africa.

Methods: In Hlabisa sub-district, the local HIV programme of the Department of Health (DoH) is decentralized in 18 clinics, where ART was offered at a CD4 count ≤500 cells/μL from January 2015 to September 2016. Within the ANRS 12249 TasP trial, implemented in part of the sub-district, universal ART (no eligibility criteria) was offered in 11 mobile clinics between March 2012 and June 2016. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0186883PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5695789PMC
December 2017
14 Reads

Primary HIV Infection: Clinical Presentation, Testing, and Treatment.

Curr Infect Dis Rep 2017 Sep 7;19(10):37. Epub 2017 Sep 7.

Service d'immunologie clinique et maladies infectieuses, CHU Henri Mondor, APHP, 51 Avenue du Maréchal de Lattre de Tassigny, 94010, Creteil, France.

Purpose Of Review: The purpose of this review was to provide current data on clinical presentation, diagnosis, and treatment of primary HIV infection (PHI).

Recent Findings: In 65 to 95% of cases, PHI causes acute retroviral syndrome presenting with unspecific flu-like symptoms. Symptomatic PHI was associated with a faster clinical and immunological progression of HIV infection. Read More

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http://dx.doi.org/10.1007/s11908-017-0588-3DOI Listing
September 2017
8 Reads

Mother-to-child transmission of HIV in Kenya: A cross-sectional analysis of the national database over nine years.

PLoS One 2017 29;12(8):e0183860. Epub 2017 Aug 29.

Clinton Health Access Initiative, Boston, Massachusetts, United States of America.

Objective: To describe factors associated with mother-to-child HIV transmission (MTCT) in Kenya and identify opportunities to increase testing/care coverage.

Design: Cross-sectional analysis of national early infant diagnosis (EID) database.

Methods: 365,841 Kenyan infants were tested for HIV from January 2007-July 2015 and results, demographics, and treatment information were entered into a national database. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0183860PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5574578PMC
October 2017
19 Reads
3.234 Impact Factor

Oesophageal candidiasis and squamous cell cancer in patients with gain-of-function STAT1 gene mutation.

United European Gastroenterol J 2017 Aug 6;5(5):625-631. Epub 2016 Dec 6.

Departments of Gastroenterology and Clinical Immunology, County Durham and Darlington NHS Foundation Trust, County Durham, UK.

Background: Oesophageal candidiasis is a common, usually self-limiting opportunistic infection, but long-term infection with is known to predispose to oral and oesophageal squamous cell cancer (SCC). Permissive factors that lead to immune deficiencies can underlie persistent or recurring candidiasis, called chronic mucocutaneous candidiasis (CMC). Secondary immune deficiencies are most often due to human immunodeficiency virus (HIV) infection, antibiotic use and immunosuppressive treatment (steroids, chemotherapy). Read More

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http://dx.doi.org/10.1177/2050640616684404DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5548354PMC
August 2017
13 Reads

Very low sensitivity of wet mount microscopy compared to PCR against culture in the diagnosis of vaginal trichomoniasis in Uganda: a cross sectional study.

BMC Res Notes 2017 Jul 6;10(1):259. Epub 2017 Jul 6.

Department of Medical Microbiology, Makerere University College of Health Sciences, P.O. Box 7072, Kampala, Uganda.

Background: Trichomonas vaginalis (TV) causes the Trichomoniasis Syndrome composed of vaginitis in women, urethritis in men and tube infection in both sexes. This infection is strongly associated with premature rupture of membranes, preterm delivery, low birth weight, promoting HIV sexual transmission and infertility. Prevention of these complications requires accurate early detection and effective treatment of infected individuals. Read More

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http://bmcresnotes.biomedcentral.com/articles/10.1186/s13104
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http://dx.doi.org/10.1186/s13104-017-2581-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5501264PMC
July 2017
10 Reads

New-onset type 2 diabetes mellitus among patients receiving HIV care at Newlands Clinic, Harare, Zimbabwe: retrospective cohort analysis.

Trop Med Int Health 2017 07 8;22(7):839-845. Epub 2017 Jun 8.

Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland.

Objective: To assess the incidence and associated factors of Type 2 Diabetes Mellitus (T2DM) among people living with HIV (PLHIV) in Zimbabwe.

Methods: We analysed data of all HIV-infected patients older than 16 years who attended Newlands Clinic between March 1, 2004 and April 29, 2015. The clinic considers patients whose random blood sugar is higher than 11. Read More

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http://dx.doi.org/10.1111/tmi.12896DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5662202PMC
July 2017
37 Reads
2.329 Impact Factor

A Case of Early Neurosyphilis.

J La State Med Soc 2017 Mar-Apr;169(2):47-48. Epub 2017 Apr 15.

Department of Internal Medicine, LSU Health in Baton Rouge, LA.

Introduction: Neurosyphilis is an infection of the central nervous system by Treponema pallidum, which can occur after the initial syphilis infection. Although commonly associated with late stage disease, patients with early neurosyphilis may present with acute syphilitic meningitis, meningovascular syphilis, or uveitis.

Case: A 28 year old man with a past medical history of HIV (CD4 364);, and recent diagnosis of uveitis presented to the Emergency Department with a positive RPR result. Read More

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September 2017
4 Reads

The prevalence of HIV among adults with pulmonary TB at a population level in Zambia.

BMC Infect Dis 2017 03 29;17(1):236. Epub 2017 Mar 29.

KNCV Tuberculosis Foundation, The Hague, the Netherlands.

Background: Tuberculosis and HIV co-infection is one of the main drivers of poor outcome for both diseases in Zambia. HIV infection has been found to predict TB infection/disease and TB has been reported as a major cause of death among individuals with HIV. Improving case detection of TB/HIV co-infection has the potential to lead to early treatment of both conditions and can impact positively on treatment outcomes. Read More

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http://dx.doi.org/10.1186/s12879-017-2345-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5372321PMC
March 2017
12 Reads

Hypogonadism in the HIV-Infected Man.

Curr Treat Options Infect Dis 2017 14;9(1):104-116. Epub 2017 Feb 14.

Department of Infectious Diseases and HIV Medicine, Leicester Royal Infirmary, University Hospitals of Leicester NHS Trust, Leicester, LE1 5WW UK.

Low testosterone levels are frequently observed among men with treated and untreated HIV infection. However, the interpretations of biochemical measurements of testicular function are challenging and need to be considered in the context of the clinical presentation and scenario. The distinction between primary and secondary hypogonadism and determination of the underlying clinical pathophysiology are not always straightforward. Read More

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http://dx.doi.org/10.1007/s40506-017-0110-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5346114PMC
February 2017
8 Reads

Recent advances in AIDS-related cryptococcal meningitis treatment with an emphasis on resource limited settings.

Expert Rev Anti Infect Ther 2017 04 9;15(4):331-340. Epub 2017 Feb 9.

a Division of Infectious Diseases & International Medicine, Department of Medicine , University of Minnesota , Minneapolis , MN , USA.

Introduction: Recent advances in the treatment and prevention of cryptococcal meningitis have the potential to decrease AIDS-related deaths. Areas covered: Targeted screening for asymptomatic cryptococcal antigenemia in persons with AIDS is a cost effective method for reducing early mortality in patients on antiretroviral therapy. For persons with symptomatic cryptococcal meningitis, optimal initial management with amphotericin and flucytosine improves survival compared to alternative therapies; however, amphotsericin is difficult to administer and flucytosine has not been available in middle or low income countries, where cryptococcal meningitis is most prevalent. Read More

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https://www.tandfonline.com/doi/full/10.1080/14787210.2017.1
Publisher Site
http://dx.doi.org/10.1080/14787210.2017.1285697DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5602588PMC
April 2017
5 Reads

Neurological manifestations of HIV-AIDS at a tertiary care institute in North Eastern India.

Neurol India 2017 Jan-Feb;65(1):64-68

Department of Neurology, North Eastern Indira Gandhi Regional Institute of Health and Medical Sciences (NEIGRIHMS), Shillong, Meghalaya, India.

Background: The nervous system is among the most frequent and serious targets of human immunodeficiency virus (HIV) infection. The infection usually occurs in patients with profound immunosuppression. In 10 - 20% of the patients, the presence of a neurological disease is the first manifestation of symptomatic HIV infection. Read More

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http://dx.doi.org/10.4103/0028-3886.198203DOI Listing
January 2017
26 Reads
1.080 Impact Factor

Predictors of poor retention on antiretroviral therapy as a major HIV drug resistance early warning indicator in Cameroon: results from a nationwide systematic random sampling.

BMC Infect Dis 2016 Nov 15;16(1):678. Epub 2016 Nov 15.

National HIV drug resistance surveillance and prevention Working Group (HIVDR-WG), Ministry of Public Health, Yaoundé, Cameroon.

Background: Retention on lifelong antiretroviral therapy (ART) is essential in sustaining treatment success while preventing HIV drug resistance (HIVDR), especially in resource-limited settings (RLS). In an era of rising numbers of patients on ART, mastering patients in care is becoming more strategic for programmatic interventions. Due to lapses and uncertainty with the current WHO sampling approach in Cameroon, we thus aimed to ascertain the national performance of, and determinants in, retention on ART at 12 months. Read More

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http://dx.doi.org/10.1186/s12879-016-1991-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5111226PMC
November 2016
27 Reads

A Study of Pap Smear in HIV-Positive Females.

J Obstet Gynaecol India 2016 12 6;66(6):453-459. Epub 2016 Jun 6.

B J Medical College, Pune, India.

Background: HIV-positive females are more likely to have abnormal Pap smears than HIV-negative women. These abnormal Pap smears are usually associated with low CD4 cell counts and human papilloma virus infection.

Materials And Methods: This was a prospective hospital-based study from April 2013 till March 2014. Read More

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http://dx.doi.org/10.1007/s13224-016-0908-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5080227PMC
December 2016
7 Reads

Immune recovery in acute and chronic HIV infection and the impact of thymic stromal lymphopoietin.

BMC Infect Dis 2016 Oct 21;16(1):591. Epub 2016 Oct 21.

Department of Infectious Diseases, Viro-Immunology Research Unit, University Hospital of Copenhagen Rigshospitalet, Copenhagen, Denmark.

Background: Symptomatic primary HIV infection is associated with an adverse prognosis, and immediate initiation of combination antiretroviral therapy (cART) is recommended. However, little is known about immunological predictors of immune recovery. Thymic Stromal Lymphopoietin (TSLP) is a cytokine that promotes CD4+ T cells homeostatic polyclonal proliferation and regulates Th17/regulatory T-cell balance, immunological functions known to be affected during primary HIV infection. Read More

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http://dx.doi.org/10.1186/s12879-016-1930-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5073883PMC
October 2016
10 Reads

Loss of cerebellar neurons in the progression of lentiviral disease: effects of CNS-permeant antiretroviral therapy.

J Neuroinflammation 2016 10 14;13(1):272. Epub 2016 Oct 14.

Molecular Neuroscience, Institute of Anatomy and Cell Biology, Philipps University Marburg, Robert-Koch-Str. 8, 35032, Marburg, Germany.

Background: The majority of investigations on HIV-associated neurocognitive disorders (HAND) neglect the cerebellum in spite of emerging evidence for its role in higher cognitive functions and dysfunctions in common neurodegenerative diseases.

Methods: We systematically investigated the molecular and cellular responses of the cerebellum as contributors to lentiviral infection-induced neurodegeneration, in the simian immunodeficiency virus (SIV)-infected rhesus macaque model for HIV infection and HAND. Four cohorts of animals were studied: non-infected controls, SIV-infected asymptomatic animals, and SIV-infected AIDS-diseased animals with and without brain-permeant antiretroviral treatment. Read More

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http://dx.doi.org/10.1186/s12974-016-0726-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5064958PMC
October 2016
13 Reads

Review of functional MRI in HIV: effects of aging and medication.

J Neurovirol 2017 02 7;23(1):20-32. Epub 2016 Oct 7.

Department of Psychiatry, University Medical Center Utrecht, Heidelberglaan 100, 3508 GA, Utrecht, The Netherlands.

HIV-associated neurocognitive disorder (HAND) is a frequently occurring comorbidity of HIV infection. Evidence suggests this condition starts subclinical before a progression to a symptomatic stage. Blood oxygenated level dependent (BOLD) fMRI has shown to be a sensitive tool to detect abnormal brain function in an early stage and might therefore be useful to evaluate the effect of HIV infection on brain function. Read More

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http://dx.doi.org/10.1007/s13365-016-0483-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5329077PMC
February 2017
3 Reads

Late Diagnosis Due to Missed Opportunities and Inadequate Screening Strategies in HIV Infected Mexican Women.

AIDS Behav 2017 Feb;21(2):505-514

Infectious Diseases Department, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Vasco de Quiroga 15, Colonia Sección XVI, Delegación Tlalpan, 14000, Mexico City, DF, Mexico.

Late diagnosis of HIV remains a public health issue in Mexico. Most national programs target high-risk groups, not including women. More data on factors associated with late diagnosis and access to care in women are needed. Read More

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http://dx.doi.org/10.1007/s10461-016-1560-1DOI Listing
February 2017
9 Reads

Clinical spectrum and outcome of pulmonary nocardiosis: 5-year experience.

Lung India 2016 Jul-Aug;33(4):398-403

Department of Pulmonary Medicine, Dayanand Medical College and Hospital, Ludhiana, Punjab, India.

Background: Pulmonary nocardiosis is a rare but a life-threatening infection caused by Nocardia spp. The diagnosis is often missed and delayed resulting in delay in appropriate treatment and thus higher mortality.

Aim: In this study, we aim to evaluate the clinical spectrum and outcome of patients with pulmonary nocardiosis. Read More

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http://dx.doi.org/10.4103/0970-2113.184873DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4948227PMC
August 2016
5 Reads

Spectrum of Opportunistic Fungal Infections in HIV/AIDS Patients in Tertiary Care Hospital in India.

Can J Infect Dis Med Microbiol 2016 20;2016:2373424. Epub 2016 Jun 20.

Department of Medicine, Maulana Azad Medical College and Associated Lok Nayak Hospitals, New Delhi 110002, India.

HIV related opportunistic fungal infections (OFIs) continue to cause morbidity and mortality in HIV infected patients. The objective for this prospective study is to elucidate the prevalence and spectrum of common OFIs in HIV/AIDS patients in north India. Relevant clinical samples were collected from symptomatic HIV positive patients (n = 280) of all age groups and both sexes and subjected to direct microscopy and fungal culture. Read More

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http://dx.doi.org/10.1155/2016/2373424DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4931070PMC
July 2016
3 Reads

Alanine aminotransferase, HCV RNA levels and pro-inflammatory and pro-fibrogenic cytokines/chemokines during acute hepatitis C virus infection.

Virol J 2016 Feb 24;13:32. Epub 2016 Feb 24.

The Kirby Institute, UNSW Australia, Wallace Wurth Building, Sydney, 2052, Australia.

Background: This study assessed the association of alanine-aminotransferase (ALT) and hepatitis C virus (HCV) RNA levels with pro-inflammatory and pro-fibrogenic cytokines and chemokines during acute HCV infection to provide further insight into the potential HCV immunopathogenesis.

Methods: Participants in the ATAHC study, a prospective study of recent HCV infection, with detectable HCV RNA at the time of HCV detection were included. Plasma levels of 27 cytokines and chemokines were measured and their correlation with ALT and HCV RNA levels were assessed. Read More

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http://dx.doi.org/10.1186/s12985-016-0482-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4765111PMC
February 2016
31 Reads
2.181 Impact Factor

Concerns about covert HIV testing are associated with delayed presentation in Ethiopian adults with suspected malaria: a cross-sectional study.

BMC Public Health 2016 Feb 1;16:102. Epub 2016 Feb 1.

Division of Epidemiology and Public Health, University of Nottingham, Nottingham, UK.

Background: Although early diagnosis and prompt treatment is important in preventing mortality from malaria, presentation of symptomatic individuals is often relatively late. One possible contributing factor is that fear of covert human immunodeficiency virus (HIV) testing delays presentation in adults. We aimed to survey the magnitude of such concerns and their association with delayed presentation with suspected malaria. Read More

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http://dx.doi.org/10.1186/s12889-016-2773-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4736270PMC
February 2016
17 Reads

Hospital admissions from a pediatric HIV care and treatment program in Malawi.

BMC Pediatr 2016 Jan 30;16:22. Epub 2016 Jan 30.

Baylor Children's Foundation Malawi, Lilongwe, Malawi.

Background: The scale up of pediatric antiretroviral treatment programs across Sub-Saharan Africa over the last decade has brought increasing numbers of children into HIV care. This patient population requiring life-long care presents new challenges in the outpatient and inpatient settings. We sought to describe hospitalizations from a large pediatric HIV treatment facility to better understand the scope of the situation and identify areas for improved care delivery. Read More

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http://dx.doi.org/10.1186/s12887-016-0556-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4736238PMC
January 2016
2 Reads

Clinical Features and Outcomes of Patients With Symptomatic Kaposi Sarcoma Herpesvirus (KSHV)-associated Inflammation: Prospective Characterization of KSHV Inflammatory Cytokine Syndrome (KICS).

Clin Infect Dis 2016 Mar 12;62(6):730-738. Epub 2015 Dec 12.

HIV and AIDS Malignancy Branch.

Background: Kaposi sarcoma herpesvirus (KSHV) is the cause of Kaposi sarcoma (KS), primary effusion lymphoma (PEL), and a form of Castleman disease (KSHV-MCD). Recently a KSHV-associated inflammatory cytokine syndrome (KICS) distinct from KSHV-MCD was reported.

Methods: We prospectively characterized the clinical, laboratory, virologic and immunologic features of KICS by evaluating symptomatic adults with KSHV using a prespecified definition. Read More

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http://dx.doi.org/10.1093/cid/civ996DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4772848PMC
March 2016
22 Reads

Serum TRSUT Titer ≥1: 16 Is a Predictor for Neurosyphilis Among HIV-Infected Patients With Concurrent Syphilis and No Neurological Symptoms.

Medicine (Baltimore) 2015 Nov;94(45):e2023

From the Department of Infectious Disease, Shanghai Public Health Clinical Center, Fudan University (J-JS, Z-YW, J-YS, Y-ZS, LL, J-RW, R-FZ, H-ZL); Department of Infectious Disease, Huashan Hospital Affiliated to Fudan University (H-ZL); and Department of Internal Medicine, Shanghai Medical College, Fudan University, Shanghai, China (H-ZL).

Investigating the predictors for lumbar puncture to diagnose the asymptomatic neurosyphilis among HIV and syphilis co-infected patients in Shanghai, China. Respectively, screening the medical records from August 1, 2009 to June 30, 2015. Those HIV-infected patients with concurrent syphilis who had received lumbar puncture were selected and their clinical and demographic data were recorded. Read More

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http://dx.doi.org/10.1097/MD.0000000000002023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4912298PMC
November 2015
12 Reads

Overcoming the challenge of diagnosis of early HIV infection: a stepping stone to optimal patient management.

Expert Rev Anti Infect Ther 2015 ;13(10):1189-93

b 2 Research Institute of the McGill University Health Centre: Glen site, Montréal, QC, Canada.

Prompt identification of individuals during the highly infectious acute or early stage of HIV infection has implications for both patient management and public health interventions. The studies on natural history of HIV infection over the last three decades have uncovered several clinical features and virological markers to diagnose early infection. However, the brevity of the acute symptomatic phase combined with the difficulty in identifying non-specific signs and symptoms poses diagnosis of early HIV infection as a remaining challenge. Read More

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http://dx.doi.org/10.1586/14787210.2015.1077701DOI Listing
June 2016
6 Reads

Partner HIV serostatus disclosure and determinants of serodiscordance among prevention of mother to child transmission clients in Nigeria.

BMC Public Health 2015 Aug 28;15:827. Epub 2015 Aug 28.

United States Agency for International Development (USAID), Abuja, FCT, Nigeria.

Background: Serodiscordance exists when the known HIV result of one member of a couple pair is positive while that of his/her partner is negative. In sub-Saharan Africa, in stable long-term couple partnerships (married or cohabiting), serodiscordance is a growing source of HIV-transmissions. This study aimed to ascertain across Nigeria, serodiscordance prevalence, partner HIV status disclosure and explore associations between suspected determinants and serodiscordance among PMTCT enrolled HIV positive pregnant women and their partners. Read More

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http://bmcpublichealth.biomedcentral.com/articles/10.1186/s1
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http://dx.doi.org/10.1186/s12889-015-2155-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4551711PMC
August 2015
29 Reads

Early diagnosis is critical to ensure good outcomes in HIV-infected children: outlining barriers to care.

AIDS Care 2016 14;28(1):32-42. Epub 2015 Aug 14.

c Department of Paediatrics and Child Health , University of Stellenbosch , Tygerberg , South Africa.

HIV-infected children require early initiation of antiretroviral therapy (ART) to ensure good outcomes. The aim was to investigate missed opportunities in childhood HIV diagnosis leading to delayed ART initiation. Baseline data were reviewed of all children aged <15 years referred over a 1-year period for ART initiation to the Kalafong Hospital HIV services in Gauteng, South Africa. Read More

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http://dx.doi.org/10.1080/09540121.2015.1066748DOI Listing
July 2016
4 Reads

Surgical manifestations of gastrointestinal cytomegalovirus infection in children: Clinical audit and literature review.

J Pediatr Surg 2015 Nov 30;50(11):1874-9. Epub 2015 Jun 30.

Department of Paediatric Surgery, Red Cross War Memorial Children's Hospital, Cape Town, South Africa.

Introduction: Gastrointestinal sequelae of cytomegalovirus are rare, usually associated with significant immune compromise, and carry a high morbidity and mortality. Gastrointestinal disease frequently requires surgical intervention for diagnosis and management.

Aim: The aim of the study is to evaluate the incidence, presentation and management of gastrointestinal cytomegalovirus disease in a pediatric population. Read More

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http://dx.doi.org/10.1016/j.jpedsurg.2015.06.018DOI Listing
November 2015
16 Reads