42,496 results match your criteria Early Pregnancy Loss


Next generation sequencing in recurrent pregnancy loss-approaches and outcomes.

Eur J Med Genet 2019 Apr 13. Epub 2019 Apr 13.

Department of Pathology and Laboratory Medicine, University of British Columbia and, Child and Family Research Institute, 950 West 28th, Vancouver BC, Canada. Electronic address:

Next generation sequencing (NGS) has revolutionized the diagnosis of postnatal genetic diseases, but so far has been used less frequently to study reproductive disorders. Here we provide an overview of approaches and outcomes of genome sequencing for identifying causes of recurrent pregnancy loss (RPL). This includes exome sequencing to look for pathogenic sequence changes in the whole exome or in a preselected list of genes considered important for early embryonic development and pregnancy maintenance, as well as low coverage whole genome sequencing useful for identifying cryptic balanced chromosome rearrangements and copy number variants (CNVs) in couples with RPL and miscarriages. Read More

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http://dx.doi.org/10.1016/j.ejmg.2019.04.001DOI Listing
April 2019
1 Read

The Problem of Spontaneous Abortion: Is the Pro-Life Position Morally Monstrous?

New Bioeth 2019 Apr 16:1-18. Epub 2019 Apr 16.

b School of Health and Social Care , London South Bank University , London , UK.

A substantial proportion of human embryos spontaneously abort soon after conception, and ethicists have argued this is problematic for the pro-life view that a human embryo has the same moral status as an adult from conception. Firstly, if human embryos are our moral equals, this entails spontaneous abortion is one of humanity's most important problems, and it is claimed this is absurd, and a reductio of the moral status claim. Secondly, it is claimed that pro-life advocates do not act as if spontaneous abortion is important, implying they are failing to fulfill their moral obligations. Read More

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http://dx.doi.org/10.1080/20502877.2019.1602376DOI Listing
April 2019
1 Read

Brucellosis in pregnancy: results of multicenter ID-IRI study.

Eur J Clin Microbiol Infect Dis 2019 Apr 15. Epub 2019 Apr 15.

Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, UK.

Brucellosis in pregnant women is reported to be associated with obstetric complications (OCs), and adequate data for human brucellosis during pregnancy are largely lacking. We performed this multicenter retrospective cross-sectional study to evaluate the epidemiology, clinical course, treatment responses, and outcomes of brucellosis among pregnant women. The study period comprised a 14-year period from January 2002 to December 2015. Read More

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http://link.springer.com/10.1007/s10096-019-03540-z
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http://dx.doi.org/10.1007/s10096-019-03540-zDOI Listing
April 2019
2 Reads

Outcomes of Congenital Zika Virus Infection During an Outbreak in Valle del Cauca, Colombia.

Pediatr Infect Dis J 2019 Apr 10. Epub 2019 Apr 10.

Department of Pediatrics, Universidad del Valle, Cali, Colombia.

Background: Despite increasing information in the literature regarding congenital Zika infection, gaps remain in our knowledge of its clinical manifestations.

Methods: We did a prospective observational study of exposed fetuses and infants whose mothers developed symptomatic and confirmed Zika infection during pregnancy in Valle del Cauca, Colombia. We performed neurological, ophthalmological and audiological evaluations, and classified outcomes as possibly or uncertainly related to Zika. Read More

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http://Insights.ovid.com/crossref?an=00006454-900000000-9644
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http://dx.doi.org/10.1097/INF.0000000000002307DOI Listing
April 2019
3 Reads

Maternal Risk Factors and Perinatal Characteristics in Congenital Diaphragmatic Hernia: A Nationwide Population-Based Study.

Fetal Diagn Ther 2019 Apr 12:1-8. Epub 2019 Apr 12.

Department of Pediatric Surgery, Karolinska University Hospital, Stockholm, Sweden.

Background: The etiology of congenital diaphragmatic hernia (CDH) remains poorly understood. We hypothesize that environmental factors play an important role in the development of CDH.

Aim: The objective of this study was to investigate associated maternal risk factors in pregnancies with CDH. Read More

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http://dx.doi.org/10.1159/000497619DOI Listing
April 2019
2 Reads

Quality Improvement Opportunities Identified Through Case Review of Pregnancy-Related Deaths From Obstetric Hemorrhage.

J Obstet Gynecol Neonatal Nurs 2019 Apr 11. Epub 2019 Apr 11.

Objective: To analyze quality improvement opportunities (QIOs) identified through review of cases of maternal death from obstetric hemorrhage by the California Pregnancy-Associated Mortality Review Committee.

Design: Qualitative descriptive using thematic analysis.

Sample: A total of 159 QIOs identified from 33 cases of pregnancy-related deaths from obstetric hemorrhage in California from 2002 to 2007. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08842175193004
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http://dx.doi.org/10.1016/j.jogn.2019.03.002DOI Listing
April 2019
2 Reads

Influence of poly(I:C) variability on thermoregulation, immune responses and pregnancy outcomes in mouse models of maternal immune activation.

Brain Behav Immun 2019 Apr 10. Epub 2019 Apr 10.

Institute of Pharmacology and Toxicology, University of Zurich - Vetsuisse, Zurich, Switzerland.

Maternal immune activation (MIA) models that are based on administration of the viral mimetic, poly(I:C), are widely used as experimental tools to study neuronal and behavioral dysfunctions in relation to immune-mediated neurodevelopmental disorders and mental illnesses. Evidence from investigations in non-pregnant rodents suggests that different poly(I:C) products can vary in terms of their immunogenicity, even if they are obtained from the same vendor. The present study aimed at extending these findings to pregnant mice, while also controlling various poly(I:C) products for potential contamination with lipopolysaccharide (LPS). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08891591193012
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http://dx.doi.org/10.1016/j.bbi.2019.04.019DOI Listing
April 2019
3 Reads

"Provoked" feto-maternal hemorrhage may represent insensible cell exchange in pregnancies from 6-22weeks gestational age.

Contraception 2019 Apr 10. Epub 2019 Apr 10.

The University of Rochester Medical Center, Rochester, NY.

Objective: To quantify spontaneous and provoked fetal to maternal cell exchange in the first half of pregnancy. Transfer of fetal red blood cells (FRBCs) into the maternal circulation during the first half of pregnancy is poorly characterized but of clinical relevance for miscarriage management and invasive procedures.

Study Design: Prospective, descriptive cohort study of women presenting for surgical termination of pregnancy with sonographically confirmed gestational age (GA). Read More

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http://dx.doi.org/10.1016/j.contraception.2019.03.051DOI Listing
April 2019
1 Read

Comparison of Celiac Disease Markers in Women with Early Recurrent Pregnancy Loss and Normal Controls.

Am J Reprod Immunol 2019 Apr 12:e13127. Epub 2019 Apr 12.

Division of Reproductive Endocrinology, Department of Obstetrics and Gynecology, Vanderbilt University School of Medicine and Fertility Associates of Memphis, 80Humphreys Center #307, Memphis, TN, 38120, USA.

Problem: Celiac disease (CD) is an autoimmune intestinal inflammatory disease triggered by gluten in the diet. Untreated CD has been associated with pregnancy loss and infertility. The purpose of this study was to screen unselected women with recurrent pregnancy loss (RPL) for markers of CD to determine if a correlation exists between RPL and CD serum markers. Read More

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http://dx.doi.org/10.1111/aji.13127DOI Listing
April 2019
3 Reads

Characteristics of midluteal phase uterine artery hemodynamics in patients with recurrent pregnancy loss.

J Obstet Gynaecol Res 2019 Apr 11. Epub 2019 Apr 11.

Department of Reproductive Medical Center, The First People's Hospital of Yunnan Province, Kunming, China.

Aim: To study the association in resistance to uterine artery blood flow and recurrent pregnancy loss (RPL) and find its potential influencing factors.

Methods: A retrospective study was conducted in 870 RPL and 237 non-RPL patients visiting to the Clinic from January 2014 to February 2018. All participants underwent comprehensive examinations and were scanned by transvaginal Doppler ultrasonography during the midluteal phase to measure the pulsatility index (PI), resistance index (RI) and systolic/diastolic ratio (S/D) values of the left and right main uterine arteries. Read More

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http://dx.doi.org/10.1111/jog.13944DOI Listing
April 2019
1 Read

Sperm DNA fragmentation valued by SCSA and its correlation with conventional sperm parameters in male partner of recurrent spontaneous abortion couple.

Biosci Trends 2019 Apr 11. Epub 2019 Apr 11.

Laboratory for Reproductive Immunology, Hospital & Institute of Obstetrics and Gynecology, Shanghai Medical College, Fudan University.

The objective of this study is to evaluate the predictive value of sperm DNA fragmentation Index (DFI) in unexplained recurrent spontaneous abortion (RSA) and to investigate its correlation with conventional sperm parameters. Besides, we aimed to reveal the necessity of establishing a DFI clinical threshold of each laboratory for the prognostic diagnosis of RSA and establish our own DFI threshold. Semen samples were collected from male partners of RSA patients (n = 139) and healthy recent fathers (control, n = 200). Read More

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http://dx.doi.org/10.5582/bst.2018.01292DOI Listing
April 2019
2 Reads

Pregnancy outcomes in patients with multiple sclerosis treated with teriflunomide: Clinical study data and 5 years of post-marketing experience.

Mult Scler 2019 Apr 10:1352458519843055. Epub 2019 Apr 10.

Department of Pediatrics, Rady Children's Hospital and University of California San Diego, La Jolla, CA, USA.

Background: Teriflunomide is contraindicated in pregnancy. Some pregnancies have occurred despite guidance to use effective contraception.

Objectives: To report outcomes of pregnancies occurring in teriflunomide clinical trials and the post-marketing setting. Read More

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http://dx.doi.org/10.1177/1352458519843055DOI Listing
April 2019
1 Read

The prevalence of combined vascular endothelial growth factor, endothelial nitric oxide synthase and thrombin-activatable fibrinolysis inhibitor genetic polymorphisms among Egyptian patients with recurrent spontaneous abortion.

J Obstet Gynaecol Res 2019 Apr 10. Epub 2019 Apr 10.

Department of Obstetrics and Gynecology, Kasr Al-Ainy Faculty of Medicine, Cairo University, Cairo, Egypt.

Aim: As angiogenesis is an essential step for chorionic villi formation. Vascular endothelial growth factor (VEGF) is essential for endothelial cell proliferation. Endothelial nitric oxide synthase (eNOS) is a powerful playmaker in hypoxia-induced angiogenesis. Read More

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http://dx.doi.org/10.1111/jog.13961DOI Listing
April 2019
1 Read

S100 proteins: An emerging cynosure in pregnancy & adverse reproductive outcome.

Indian J Med Res 2018 Dec;148(Supplement):S100-S106

Department of Molecular & Human Genetics, Banaras Hindu University, Varanasi, India.

S100 proteins are calcium (Ca)-binding proteins and these have an important function in progression, manifestation and therapeutic aspects of various inflammatory, metabolic and neurodegenerative disorders. Based on their involvement in intracellular or extracellular regulatory effects, S100 proteins are classified into three subgroups: one subgroup is specialized in exerting only intracellular effects, other performs both intracellular and extracellular functions and the third subgroup members only display extracellular regulatory effects. S100 proteins are expressed particularly in vertebrates and have cell-specific expression. Read More

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http://dx.doi.org/10.4103/ijmr.IJMR_494_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6469379PMC
December 2018
2 Reads
1.661 Impact Factor

Socio-economic correlates of bereavement among women - Examining the differentials on social axes.

Indian J Med Res 2018 Dec;148(Supplement):S27-S37

Centre of Social Medicine & Community Health, School of Social Sciences, Jawaharlal Nehru University, New Delhi, India.

Death, disease and disaster can inflict anyone, anywhere and at any time. While occurrence of such an event could be absolved of any selective strike, the outcome reflects otherwise. Historical deprivations experienced by certain populations have caused more bereavement and sorrow to them than those who have experienced lesser or no deprivation. Read More

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http://dx.doi.org/10.4103/ijmr.IJMR_779_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6469374PMC
December 2018
3 Reads

Maternal, neonatal insulin resistance and neonatal anthropometrics in pregnancies following bariatric surgery.

Metabolism 2019 Apr 5. Epub 2019 Apr 5.

Fetal Medicine Unit, Academic Department of Obstetrics and Gynaecology, Institute of Reproductive and Developmental Biology, Chelsea and Westminster Hospital, Imperial College London, London, UK; Academic Department of Obstetrics and Gynaecology, Institute of Reproductive and Developmental Biology, Chelsea and Westminster Hospital, Imperial College London, London, UK. Electronic address:

Objective: An increasing number of women present pregnant having undergone bariatric surgery, a popular treatment for sustainable weight loss. The aim of the study was to investigate the effect, if any, of bariatric surgery on maternal and neonatal insulin resistance (IR) and neonatal body fat composition.

Methods: Maternal IR, at 28 weeks of gestation during 2-h 75 g oral glucose tolerance test (OGTT), neonatal IR, from umbilical cord venous blood, and neonatal birthweight and body fat composition (calculated by measuring skin folds) at birth were evaluated in 41 post-bariatric and 82 pregnant women with similar early pregnancy body mass index but no history of such surgery. Read More

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http://dx.doi.org/10.1016/j.metabol.2019.04.005DOI Listing
April 2019
2 Reads

Seromolecular assess of infection in pregnant women and neonatal umbilical cord blood.

EXCLI J 2019 2;18:1-7. Epub 2019 Jan 2.

Department of Biotechnology, Damghan Branch, Islamic Azad University, Damghan, Iran.

Toxoplasmosis is considered as one of the most prevalent human parasitic infections that can be transmitted from mother to the fetus. The onset of toxoplasmosis during pregnancy has clinical complications including spontaneous abortion, preterm labor, stillbirth and fetal abnormalities. The aim of this study was to investigate the prevalence of Toxoplasmosis infection in pregnant women and their infants in Lorestan province, Western Iran. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449666PMC
January 2019
2 Reads
0.857 Impact Factor

Impaired Placentation and Early Pregnancy Loss in Patients with MTHFR Polymorphisms and Type-1 Diabetes Mellitus.

Fetal Pediatr Pathol 2019 Apr 7:1-11. Epub 2019 Apr 7.

b Department of Obstetrics and Gynecology, Division of Perinatology, Hacettepe University Faculty of Medicine , Ankara , Turkey.

Objective: To evaluate the impact of type-1 diabetes mellitus (DM) and methylenetetrahydrofolate reductase (MTHFR) polymorphisms on impaired placentation leading to early pregnancy loss.

Methods: Miscarriage materials were obtained from eight pregnant women with type-1 DM without MTHFR polymorphism, eight with MTHFR polymorphisms without type-1 DM, and eight controls with neither DM nor MTHFR polymorphisms. Insulin-like growth factor-1 (IGF-1), leukemia inhibitory factor (LIF), and Beclin-1 expression were assessed to evaluate placentation. Read More

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http://dx.doi.org/10.1080/15513815.2019.1600623DOI Listing
April 2019
2 Reads

An observation study of the emergency intervention in placenta accreta spectrum.

Arch Gynecol Obstet 2019 Apr 5. Epub 2019 Apr 5.

Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China.

Objective: This study explored the probability and outcome of delivery in women with placenta accreta spectrum (PAS) according to gestational age at delivery.

Methods: A retrospective cohort study among women with PAS who had cesarean section was conducted. The gestational week (gw) of delivery and estimated blood loss (EBL) were recorded. Read More

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http://link.springer.com/10.1007/s00404-019-05136-6
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http://dx.doi.org/10.1007/s00404-019-05136-6DOI Listing
April 2019
1 Read

Effect of levothyroxine supplementation on pregnancy loss and preterm birth in women with subclinical hypothyroidism and thyroid autoimmunity: a systematic review and meta-analysis.

Hum Reprod Update 2019 May;25(3):344-361

Department of Reproduction and Genetics, the First Affiliated Hospital of Kunming Medical University, No. 295 Xi Chang road, Kunming, China.

Background: Subclinical hypothyroidism (SCH) and thyroid autoimmunity (TAI) are associated with adverse pregnancy outcomes such as pregnancy loss and preterm birth. However, the ability of levothyroxine (LT4) supplementation to attenuate the risks of these outcomes remains controversial.

Objective And Rationale: This systematic review and meta-analysis was conducted to determine the effect of LT4 supplementation on pregnancy loss rate (PLR) and preterm birth rate (PBR) among pregnant women with SCH and TAI. Read More

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http://dx.doi.org/10.1093/humupd/dmz003DOI Listing
May 2019
4 Reads

Four years' experience of a ROTEM -guided algorithm for treatment of coagulopathy in obstetric haemorrhage.

Anaesthesia 2019 Apr 5. Epub 2019 Apr 5.

Chelsea and Westminster Hospital NHS Foundation Trust, London, UK.

We report four years of observational data from a large UK hospital and tertiary referral unit, following the introduction of a rotational thromboelastometry-guided algorithm for treatment of coagulopathy in major obstetric haemorrhage. Fibrinogen concentrate was used to treat acquired hypofibrinogenaemia as defined by a FibTEM A5 value of < 7 mm, or 7-12 mm with ongoing or high risk of haemorrhage. Of 32,647 deliveries over 4 years, 893 (2. Read More

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http://dx.doi.org/10.1111/anae.14628DOI Listing
April 2019
1 Read

Significant Clinical Manifestations in Ballantyne Syndrome, after a Case Report and Literature Review: Recognizing Preeclampsia as a Differential Diagnosis.

Case Rep Obstet Gynecol 2019 5;2019:2013506. Epub 2019 Mar 5.

Immunology Research Laboratory, International Program of Medicine, Universidad Autonoma de Guadalajara, 44100, Mexico.

Ballantyne syndrome (BS) also called mirror syndrome is defined by the presence of a clinical triad that includes fetal hydrops and placental and maternal edema. Here we present a clinical case of a 34-year-old woman with a 29 weeks' pregnancy, who developed BS and fetal loss probably due to failure in prompt recognition of a rapidly growing sacrococcygeal teratoma (SCT). Due to similarities in clinical presentation with preeclampsia and the importance in early identification of the source for BS, we underwent a literature review in order to identify significant signs and symptoms, as well as sonographic changes, in order to help clinicians to make this prompt recognition, identification of the cause, and early management of BS, which will have an important impact in maternal and fetal survival. Read More

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http://dx.doi.org/10.1155/2019/2013506DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425318PMC
March 2019
2 Reads

Caveolin-1 promotes trophoblast cell invasion through the focal adhesion kinase (FAK) signalling pathway during early human placental development.

Reprod Fertil Dev 2019 Apr 4. Epub 2019 Apr 4.

Normal implantation and placental development depend on the appropriate differentiation and invasion of trophoblast cells. Inadequate trophoblast cell invasion results in pregnancy-related disorders, which endanger both mother and fetus; however, the mechanism of early placental development has not been fully explained. In this study we conducted gene expression profile analysis using mouse placental tissues at different developmental stages (embryonic day (E)7. Read More

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http://dx.doi.org/10.1071/RD18296DOI Listing
April 2019
2 Reads

A successful pregnancy in a patient with secondary hypertension caused by adrenal adenoma: a case report.

BMC Pregnancy Childbirth 2019 Apr 3;19(1):116. Epub 2019 Apr 3.

Department of cardiology, West China Hospital, Sichuan University, Chengdu, China.

Background: Secondary hypertension is a rare complication in pregnancy that causes poor outcomes, such as preeclampsia, premature delivery, intrauterine growth retardation, stillbirths, spontaneous abortion or intrauterine death. Cushing's disease caused by an adrenal adenoma is rare during pregnancy and may be overlooked by obstetricians and physicians, but can lead to hypertension, diabetes mellitus and an increased risk of fetal and maternal morbidity. Approximately 200 cases have been reported in the literature. Read More

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http://dx.doi.org/10.1186/s12884-019-2262-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448298PMC
April 2019
2 Reads

FasL on decidual macrophages mediates trophoblast apoptosis: A potential cause of recurrent miscarriage.

Int J Mol Med 2019 Mar 26. Epub 2019 Mar 26.

Reproductive Medical Center, Renmin Hospital of Wuhan University and Hubei Clinic Research Center for Assisted Reproductive Technology and Embryonic Development, Wuhan, Hubei 430060, P.R. China.

Macrophages can induce Fas ligand (FasL)‑mediated apoptosis, and the deregulation of apoptosis is known to be associated with recurrent miscarriage (RM). The aim of the present study was to investigate the possible involvement of FasL in macrophage‑mediated trophoblast apoptosis and its potential role in RM. Human decidual and placental villous tissues were collected from 81 women (21 for the RM group, 26 for the spontaneous abortion group and 34 for the control group) at 7‑9 weeks of gestation. Read More

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http://dx.doi.org/10.3892/ijmm.2019.4146DOI Listing
March 2019
2 Reads
1.880 Impact Factor

Complications in Early Pregnancy.

Emerg Med Clin North Am 2019 May;37(2):219-237

Department of Emergency Medicine, Canton-Potsdam Hospital, 50 Leroy Street, Potsdam, NY 13676, USA. Electronic address:

Early in pregnancy women frequently experience nausea, vomiting, and vaginal bleeding. Nausea and vomiting can be mild, managed by dietary modifications and medications, or severe, requiring intravenous fluids and medications. Care should be used when selecting medications for nausea to avoid additional side effects or potential harm to the developing fetus. Read More

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http://dx.doi.org/10.1016/j.emc.2019.01.004DOI Listing
May 2019
4 Reads

Pregnancy and Neonatal Outcomes Following Prenatal Exposure to Dolutegravir.

J Acquir Immune Defic Syndr 2019 Mar 29. Epub 2019 Mar 29.

UCL Great Ormond Street Institute of Child Health, London, UK.

Background: Birth outcomes data with dolutegravir exposure during pregnancy, particularly in the first trimester, are needed.

Setting: Data were prospectively collected from the Antiretroviral Pregnancy Registry and European Pregnancy and Paediatric HIV Cohort Collaboration.

Methods: We reviewed 2 large, independent antiretroviral pregnancy registries to assess birth outcomes associated with maternal dolutegravir treatment during pregnancy. Read More

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http://dx.doi.org/10.1097/QAI.0000000000002035DOI Listing
March 2019
1 Read

Risk factors, early and late postpartum complications of retained placenta: A case control study.

Eur J Obstet Gynecol Reprod Biol 2019 Mar 26;236:160-165. Epub 2019 Mar 26.

Department of Obstetrics & Gynecology, Shaare Zedek Medical Center, affiliated with the Hebrew University Hadassah School of Medicine Jerusalem, Israel. Electronic address:

Objectives: To identify risk factors and complications associated with 3 stage of labor removal of placental fragments (3 SRPF) by manual uterine revision under a strict protocol.

Study Design: Ten years retrospective register-based cohort study of vaginal deliveries. Women with 3 SRPF n = 3297 (exposed) and those without n = 97,888 (non exposed) were compared. Read More

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http://dx.doi.org/10.1016/j.ejogrb.2019.03.024DOI Listing
March 2019
5 Reads

Challenges in diagnosing and managing adult patients with Urea Cycle Disorders.

J Inherit Metab Dis 2019 Apr 1. Epub 2019 Apr 1.

National Centre for Inherited Metabolic Diseases, The Mater Misericordiae University Hospital, Dublin 7, Ireland.

Urea cycle disorders (UCD) are a group of rare inherited metabolic conditions of amino acid catabolism caused by an enzyme deficiency within the hepatic ammonia detoxification pathway. The presentation of these disorders ranges from life-threatening intoxication in the neonate to asymptomatic status in adults. Late-onset UCDs can present for the first time in adulthood and may mimic other causes of acute confusion or psychiatric diseases, and are often associated with neurological symptoms. Read More

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http://dx.doi.org/10.1002/jimd.12096DOI Listing
April 2019
3 Reads

What exactly is endometrial receptivity?

Fertil Steril 2019 Apr;111(4):611-617

Division of Reproductive Endocrinology, Department of Obstetrics and Gynecology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.

Endometrial receptivity is a complex process that provides the embryo with the opportunity to attach, invade, and develop, culminating in a new individual and continuation of the species. The window of implantation extends 3-6 days within the secretory phase in most normal women. In certain inflammatory or anatomic conditions, this window is narrowed or shifted to preclude normal implantation, leading to infertility or pregnancy loss. Read More

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http://dx.doi.org/10.1016/j.fertnstert.2019.02.009DOI Listing
April 2019
3 Reads

Evidence that antibiotic administration is effective in the treatment of a subset of patients with intra-amniotic infection/inflammation presenting with cervical insufficiency.

Am J Obstet Gynecol 2019 Mar 27. Epub 2019 Mar 27.

Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Korea. Electronic address:

Background: Cervical insufficiency is a risk factor for spontaneous midtrimester abortion or early preterm birth. Intra-amniotic infection has been reported in 8-52% of such patients, and intra-amniotic inflammation in 81%. Some professional organizations have recommended perioperative antibiotic treatment when emergency cervical cerclage is performed. Read More

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http://dx.doi.org/10.1016/j.ajog.2019.03.017DOI Listing
March 2019
3 Reads

Complication rates after chorionic villus sampling and midtrimester amniocentesis: A 7-year national registry study.

J Formos Med Assoc 2019 Mar 27. Epub 2019 Mar 27.

Department of Obstetrics and Gynecology, National Taiwan University Hospital, Taipei, Taiwan; Graduate Institute of Clinical Medicine, National Taiwan University College of Medicine, Taipei, Taiwan. Electronic address:

Purpose: To assess the complication rates following chorionic villus sampling (CVS) and midtrimester amniocentesis in Taiwan.

Methods: This is a national registry-based cohort study from Taiwan. We included all women with singleton pregnancies who received either CVS (n = 1409) or midtrimester amniocentesis (n = 250,566) during 2006-2012. Read More

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http://dx.doi.org/10.1016/j.jfma.2019.03.006DOI Listing
March 2019
2 Reads

Thyroid-stimulating hormone (TSH) serum levels and risk of spontaneous abortion: A prospective population-based cohort study.

Clin Endocrinol (Oxf) 2019 Mar 30. Epub 2019 Mar 30.

Isfahan Endocrine and Metabolism Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.

Objective: Thyroid dysfunction, a common complication of pregnancy, is associated with adverse obstetric and neonatal consequences. This study aimed to determine the effect of TSH levels on early pregnancy outcome in a prospective population-based cohort study.

Design And Methods: The serum TSH, free thyroxine, free triiodothyronine, thyroid peroxidase antibody levels and urinary iodine concentration of 418 pregnant women in their first trimester of pregnancy were measured. Read More

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http://dx.doi.org/10.1111/cen.13979DOI Listing
March 2019
2 Reads

Increased fetal chromosome detection with the use of operative hysteroscopy during evacuation of products of conception for diagnosed miscarriage.

J Minim Invasive Gynecol 2019 Mar 26. Epub 2019 Mar 26.

The Advanced Gynecologic Surgery Institute, Chicago, IL.

Study Objective: Primary objective is to determine whether incorporation of operative hysteroscopy with biopsy of products of conception, in conjunction with a suction curettage for a first trimester missed abortion, affected the rate of maternal cell contamination when chromosomal analysis was performed on the products of conception. Secondary objective was to determine the rates of retained products of conception with incorporation of hysteroscopy post suction curettage.

Design: Retrospective chart study SETTING: Private, minimally invasive surgery and infertility practice with academic-community hospital affiliation. Read More

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http://dx.doi.org/10.1016/j.jmig.2019.03.014DOI Listing
March 2019
4 Reads

Syphilis-attributable adverse pregnancy outcomes in China: a retrospective cohort analysis of 1187 pregnant women with different syphilis treatment.

BMC Infect Dis 2019 Mar 29;19(1):292. Epub 2019 Mar 29.

Division of Birth Cohort Study, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, 9 Jinsui Road, Guangzhou, 510623, China.

Background: Syphilis is responsible for a substantial burden of preventable adverse outcomes in pregnancy. The purpose of this study was to compare the frequency of adverse pregnancy outcomes among syphilis-seropositive women who received different treatment regimens at different times in Guangzhou, China.

Methods: Pregnant women with syphilis infection who received prenatal and delivery services in Guangzhou between January 2014 and December 2016 were included. Read More

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http://dx.doi.org/10.1186/s12879-019-3896-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6439997PMC
March 2019
1 Read
2.613 Impact Factor

Alarmin HMGB1 and Soluble RAGE as New Tools to Evaluate the Risk Stratification in Patients With the Antiphospholipid Syndrome.

Front Immunol 2019 14;10:460. Epub 2019 Mar 14.

Dipartimento di Medicina Sperimentale, Sapienza Università di Roma, Rome, Italy.

Antiphospholipid antibody syndrome (APS) is a systemic autoimmune disease characterized by arterial and/or venous thrombosis, pregnancy morbidity in the presence of circulating "anti-phospholipid antibodies" (aPL). One of the main target antigens of aPL is β-glycoprotein I (β-GPI). APS may occur as a primary syndrome or associated with Systemic Lupus Erythematosus (SLE). Read More

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http://dx.doi.org/10.3389/fimmu.2019.00460DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6426766PMC
March 2019
1 Read

Association between M2/ANXA5 haplotype and repeated pregnancy loss: a meta-analysis.

Fertil Steril 2019 Mar 25. Epub 2019 Mar 25.

Advanced Medical and Dental Institute, Universiti Sains Malaysia, Bertam, Penang, Malaysia.

Objective: To ascertain the magnitude and precision of the association between M2/ANXA5 haplotype and repeated pregnancy loss (RPL).

Design: Meta-analysis of odds ratios.

Setting: Not applicable. Read More

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http://dx.doi.org/10.1016/j.fertnstert.2019.01.015DOI Listing
March 2019
3 Reads

Pregnancy and stillbirth losses in dairy cows with singleton and twin pregnancies.

Acta Vet Hung 2019 Mar;67(1):115-126

1 Department and Clinic for Production Animals, University of Veterinary Medicine Budapest , H-2225 Üllő-Dóra major , Hungary.

The aim of this study was to examine the effect of twin pregnancy, fetal laterality, the number of corpora lutea (CL) and cavitary CL on pregnancy losses in Holstein-Friesian cows with a positive pregnancy diagnosis based on ultrasonography between days 29-42 after AI. Pregnancy was confirmed by transrectal palpation between days 57-70 after AI and at the time of drying-off as well. Twin pregnancy rate was 8. Read More

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http://dx.doi.org/10.1556/004.2019.013DOI Listing
March 2019
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Association between induced abortion, spontaneous abortion, and infertility respectively and the risk of psychiatric disorders in 57,770 women followed in gynecological practices in Germany.

J Affect Disord 2019 Mar 20;251:107-113. Epub 2019 Mar 20.

Department of Gynecology and Obstetrics, Philipps University of Marburg, Marburg, Germany.

Aim: Our goal was to analyze the association between induced abortion, spontaneous abortion, and infertility respectively and the risk of psychiatric disorders in 57,770 women followed in gynecological practices in Germany.

Methods: This case-control study was based on data from the Disease Analyzer database (IQVIA). Women with a first documentation of depression, anxiety, adjustment disorder, or somatoform disorder in one of 281 gynecological practices in Germany between January 2013 and December 2017 were included in this study (index date). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01650327193017
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http://dx.doi.org/10.1016/j.jad.2019.03.060DOI Listing
March 2019
3 Reads

Medical management of first trimester missed miscarriage: the efficacy and complication rate.

J Obstet Gynaecol 2019 Mar 27:1-5. Epub 2019 Mar 27.

b Department of Reproductive Medicine and Gynaecological Endocrinology, Clinic for Gynaecology and Perinatology , University Medical Centre Maribor , Maribor , Slovenia.

Our aim of the study was to evaluate the efficacy and complication rate of our inpatient medical management protocol for missed miscarriages. Three-hundred and ninety women hospitalised at our tertiary centre because of a missed miscarriage/anembryonic pregnancy in 2012-2013 were included in this retrospective study. The women underwent either a low (until 9 + 0 weeks of gestation) or high gestational age (from 9 + 1 until 15 + 6 weeks of gestation) management protocol. Read More

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http://dx.doi.org/10.1080/01443615.2018.1535577DOI Listing
March 2019
3 Reads

DNA methylation markers in obesity, metabolic syndrome, and weight loss.

Epigenetics 2019 Mar 27:1-24. Epub 2019 Mar 27.

a Department of Nutrition, Food Science and Physiology; Centre for Nutrition Research , University of Navarra , Pamplona , Spain.

The fact that not all individuals exposed to the same environmental risk factors develop obesity supports the hypothesis of the existence of underlying genetic and epigenetic elements. There is suggestive evidence that environmental stimuli, such as dietary pattern, particularly during pregnancy and early life, but also in adult life, can induce changes in DNA methylation predisposing to obesity and related comorbidities. In this context, the DNA methylation marks of each individual have emerged not only as a promising tool for the prediction, screening, diagnosis, and prognosis of obesity and metabolic syndrome features, but also for the improvement of weight loss therapies in the context of precision nutrition. Read More

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http://dx.doi.org/10.1080/15592294.2019.1595297DOI Listing
March 2019
2 Reads

Bridging therapy for achalasia in a second trimester pregnant patient.

J Family Med Prim Care 2019 Jan;8(1):289-297

Department of Gastroenterology, Naval Medical Center, San Diego, Bob Wilson Drive, San Diego, California, United States.

We present the case of a 28-year-old female who presented for primary care at 22-week gestation with type II achalasia and worsening solid/liquid dysphagia leading to pregnancy weight loss. Considering that durable therapies such as surgical myotomy and pneumatic dilatation have considerable risk, botulinum A toxin injection was selected as a temporizing bridging therapy. She had an uncomplicated post procedure course and had significant rapid improvement in dysphagia symptoms, which enabled her to progress to normal peripartum weight. Read More

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http://dx.doi.org/10.4103/jfmpc.jfmpc_389_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396631PMC
January 2019
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Prenatal ultrasound diagnosis of fetal chest wall cystic lymphangioma: An Italian case series.

Eur J Obstet Gynecol Reprod Biol 2019 Mar 18;236:139-142. Epub 2019 Mar 18.

Department of Neuroscience, Reproductive Sciences and Dentistry, School of Medicine, University of Naples Federico II, Naples, Italy; Diagnosi Ecografica e Prenatale di A.Di Meglio, Naples, Italy.

Fetal lymphangioma is a rare congenital malformation of lymphatic system that involve the skin and the subcutaneous tissue. The vast majority of the lymphangioma occurs in the neck. More rarely lymphangiomas may occur in the axillary region, including chest wall. Read More

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http://dx.doi.org/10.1016/j.ejogrb.2019.03.014DOI Listing
March 2019
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Levothyroxine in Women with Thyroid Peroxidase Antibodies before Conception.

N Engl J Med 2019 04 23;380(14):1316-1325. Epub 2019 Mar 23.

From the Institute of Metabolism and Systems Research (R.K.D.-S., C.M., M.D.K., K. Boelaert, A.C.), Tommy's National Centre for Miscarriage Research (R.K.D.-S., A.C.), and the Birmingham Clinical Trials Unit, Institute of Applied Health Research (L.J.M., K.K.S., V.C., S.F.-C.), College of Medical and Dental Sciences, University of Birmingham, the Birmingham Women's and Children's NHS Foundation Trust (R.K.D.-S., L.R., M.D.K., A.C.), and University Hospital Birmingham (P.G., R.S.), Birmingham, the Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford (K. Baker), the Miscarriage Association, Wakefield (R.B.-A.), University Hospital Coventry, University Hospitals Coventry and Warwickshire NHS Trust, Coventry (R.A., T.G., S.Q.), Burnley General Teaching Hospital, East Lancashire Hospitals NHS Trust, Lancashire (K. Bhatia), St. Mary's Hospital, Central Manchester University Hospitals NHS Foundation Trust, Manchester (E.E.-O.), University College Hospital, University College London Hospitals NHS Foundation Trust (D.J.), the Assisted Conception Unit, Guy's and St. Thomas' NHS Foundation Trust (Y.K.), St. Mary's Hospital, Imperial College Healthcare NHS Trust (R.R.), King's College Hospital NHS Foundation Trust (J.R.), and the Barts Research Centre for Women's Health, Barts and the London School of Medicine and Dentistry, Queen Mary University of London (A.T., S.T.), London, Ayrshire Maternity Unit, University Hospital Crosshouse, Kilmarnock (M.M.), Royal Bolton Hospital, Bolton NHS Foundation Trust, Bolton (K.M.), West Middlesex University Hospital, Chelsea and Westminster Hospital NHS Foundation Trust, Chelsea (N.N.), St. Michael's Hospital, University Hospitals Bristol NHS Foundation Trust, Bristol (C.O.), Queens Medical Centre, Nottingham University Hospitals NHS Trust (N.R.-F.), and the Nottingham Clinical Trials Unit, University of Nottingham, School of Medicine, Nottingham Health Sciences Partners, Queen's Medical Centre (J.D.), Nottingham, and the Princess Royal Hospital, Shrewsbury and Telford Hospital NHS Trust, Shrewsbury (A.S., M.U.) - all in the United Kingdom; and the Department of Obstetrics and Gynecology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore (S.Y.C.).

Background: Thyroid peroxidase antibodies are associated with an increased risk of miscarriage and preterm birth, even when thyroid function is normal. Small trials indicate that the use of levothyroxine could reduce the incidence of such adverse outcomes.

Methods: We conducted a double-blind, placebo-controlled trial to investigate whether levothyroxine treatment would increase live-birth rates among euthyroid women who had thyroid peroxidase antibodies and a history of miscarriage or infertility. Read More

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http://dx.doi.org/10.1056/NEJMoa1812537DOI Listing
April 2019
2 Reads

Expression of galectin-3 and apoptosis in placental villi from patients with missed abortion during early pregnancy.

Exp Ther Med 2019 Apr 31;17(4):2623-2631. Epub 2019 Jan 31.

Department of Pediatrics, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, Guangdong 510889, P.R. China.

The success of a pregnancy relies on moderate trophoblast apoptosis. If the 'inhibition-induction' balance of apoptosis is broken, a pathological pregnancy may occur. Galectin-3 has an important role in numerous biological processes, including tumor cell apoptosis. Read More

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http://dx.doi.org/10.3892/etm.2019.7227DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425259PMC
April 2019
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Updates in the management of inflammatory bowel disease during pregnancy.

Med J Aust 2019 Apr 24;210(6):276-280. Epub 2019 Mar 24.

St Vincent's Hospital, Melbourne, VIC.

The best pregnancy outcomes for women with inflammatory bowel disease (IBD) occur when their disease is in remission at conception and remains in remission throughout pregnancy. Active IBD can lead to adverse pregnancy outcomes, including spontaneous abortion, pre-term birth and low birthweight. The majority of women with IBD who are taking maintenance medication will require medication throughout the pregnancy to prevent disease relapse. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.5694/mja2.50062
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http://dx.doi.org/10.5694/mja2.50062DOI Listing
April 2019
10 Reads

The high-fertility cycle: How timely pregnancies in one lactation may lead to less body condition loss, fewer health issues, greater fertility, and reduced early pregnancy losses in the next lactation.

J Dairy Sci 2019 Mar 20. Epub 2019 Mar 20.

Department of Animal Science, Michigan State University, East Lansing 48824. Electronic address:

Body condition loss during early lactation varies among cows in the herd and is associated with future health and reproductive outcomes. The objective of this study was to gain a greater understanding of the relationship between previous calving interval and body condition change during the first 30 d in milk (DIM) and their relationship to subsequent fertility and health variables and sex ratio at birth. Dry cows and heifers (n = 851) from a single farm entered the study approximately 25 d before the due date. Read More

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http://dx.doi.org/10.3168/jds.2018-15828DOI Listing
March 2019
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Molecular investigation of uniparental disomy (UPD) in spontaneous abortions.

Eur J Obstet Gynecol Reprod Biol 2019 Mar 6;236:116-120. Epub 2019 Mar 6.

Genetics Unit, Department of General Biology, Medical School, University of Ioannina, Ioannina, Greece.

Objective: About 10-15% of all clinically recognized pregnancies end as spontaneous abortions while at least 50% of pregnancies are lost before reaching term gestation. Genetic abnormalities are responsible for ≥50% of all early miscarriages. The aim is to indentify associations between UPD and abortions and regarding UPD as pathogenetic mechanism possibly to understand the role of imprinted genes or recessive mutations in abortions. Read More

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http://dx.doi.org/10.1016/j.ejogrb.2019.03.004DOI Listing
March 2019
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Polymorphism of MTHFR 1298A>C in relation to adverse pregnancy outcomes in Chinese populations.

Mol Genet Genomic Med 2019 Mar 22:e642. Epub 2019 Mar 22.

Department of Reproduction and Genetics, Kunming Medical University First Affiliated Hospital, Kunming, Yunnan, China.

Background: Adverse pregnancy outcomes (APOs) are involved in a series of abnormal pregnancies like embryo growth arrest, spontaneous abortion, premature birth, stillbirth, fetal malformation, birth defects and other pathological pregnancy, and childbirth complications. Polymorphism of methylenetetrahydrofolate reductase gene (MTHFR, 607093) is one of the main genetic causes of APO. However, there is still debate on whether MTHFR 1298A>C, rs1801131, polymorphism is related to APO. Read More

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http://dx.doi.org/10.1002/mgg3.642DOI Listing
March 2019
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