45,730 results match your criteria Early Pregnancy Loss

Pregnancy and Viral infections: Mechanisms of fetal damage, diagnosis and prevention of neonatal adverse outcomes from cytomegalovirus to SARS-CoV-2 and Zika virus.

Biochim Biophys Acta Mol Basis Dis 2021 Jun 9:166198. Epub 2021 Jun 9.

Fetal and Perinatal Medicine and Surgery Unit, Medical and Surgical Department of Fetus, Newborn and Infant - "Bambino Gesù" Children's Hospital IRCCS, Rome, Italy.

Some maternal infections, contracted before or during pregnancy, can be transmitted to the fetus, during gestation (congenital infection), during labor and childbirth (perinatal infection) and through breastfeeding (postnatal infection). The agents responsible for these infections can be viruses, bacteria, protozoa, fungi. Among the viruses most frequently responsible for congenital infections are Cytomegalovirus (CMV), Herpes simplex 1-2, Herpes virus 6, Varicella zoster. Read More

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Nicotinic acid supplementation at a supraphysiological dose increases the bioavailability of NAD precursors in mares.

J Anim Physiol Anim Nutr (Berl) 2021 Jun 12. Epub 2021 Jun 12.

Sydney School of Veterinary Science, Faculty of Science, The University of Sydney, Camden, NSW, Australia.

NAD deficiency has recently been linked with increased occurrences of congenital abnormalities and embryonic death in human and animal subjects. Early embryonic death is a major component of pregnancy loss in mares and very little is known regarding the requirement for NAD in horses. The aim of this study was to quantify NAD and its metabolites in the plasma and urine of mares after orally administering an acute dose of nicotinic acid and determine the absorption, metabolism and excretion of this essential precursor for NAD biosynthesis. Read More

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Hysteroscopy-assisted laparoscopic salpingectomy for interstitial pregnancy without cornual resection.

Fertil Steril 2021 Jun 8. Epub 2021 Jun 8.

Reproductive Biology Associates, Atlanta, Georgia.

Objective: To illustrate a novel surgical management technique for interstitial ectopic pregnancies (IP).

Design: Video description of the case, demonstration of the surgical technique, reevaluation at the 6-week postoperative follow-up, and review of the advantages of this surgical technique for IP.

Setting: Tertiary referral center. Read More

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Systematic Review and Meta-Analysis: Safety of Vedolizumab During Pregnancy in Patients with Inflammatory Bowel Disease.

J Gastroenterol Hepatol 2021 Jun 10. Epub 2021 Jun 10.

Division of Gastroenterology, McMaster University, Hamilton.

Background And Aim: Vedolizumab is a novel monoclonal antibody used in patients with inflammatory bowel disease, often affecting women of child-bearing age. We aimed to compare maternal and fetal adverse outcomes in pregnancies of women with inflammatory bowel disease exposed to vedolizumab versus those on other treatment.

Methods: We performed a systematic literature search through December 2020 looking for studies including outcomes from pregnancies of female inflammatory bowel disease patients treated with vedolizumab. Read More

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The relationship between inflammation markers and ketonuria in hyperemesis gravidarum.

J Obstet Gynaecol Res 2021 Jun 9. Epub 2021 Jun 9.

Department of Gynecology and Obstetrics, Kütahya Health Sciences University, Kutahya, Turkey.

Objective: Hyperemesis gravidarum is an illness that starts in early pregnancy and manifests itself with oral intake problems, electrolyte imbalance, ketonuria, and weight loss. Inflammation is closely associated with the hyperemesis gravidarum, and inflammatory indicators have been studied to understand its pathophysiology. This study investigates the relationship of ketonuria levels with inflammatory markers platelet-to-lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio (MLR), and neutrophil-to-lymphocyte ratio (NLR) for hyperemesis gravidarum patients. Read More

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Womb to womb: Maternal litter size and birth weight but not adult characteristics predict early neonatal death of offspring in the common marmoset monkey.

PLoS One 2021 9;16(6):e0252093. Epub 2021 Jun 9.

Southwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, Texas, United States of America.

A singular focus on maternal health at the time of a pregnancy leaves much about perinatal mortality unexplained, especially when there is growing evidence for maternal early life effects. Further, lumping stillbirth and early neonatal death into a single category of perinatal mortality may obscure different causes and thus different avenues of screening and prevention. The common marmoset monkey (Callithrix jacchus), a litter-bearing nonhuman primate, is an ideal species in which to study the independent effects of a mother's early life and adult phenotypes on pregnancy outcomes. Read More

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Predictive Significance of Sperm DNA Fragmentation Testing in Early Pregnancy Loss in Infertile Couples Undergoing Intracytoplasmic Sperm Injection.

Res Rep Urol 2021 1;13:313-323. Epub 2021 Jun 1.

Department of Obstetrics and Gynecology, Hue University of Medicine and Pharmacy, Hue University, Hue, Vietnam.

Objective: This study aimed to determine the role of sperm DNA fragmentation as a marker that could predict early pregnancy loss (EPL), either independently or in combination with another marker or markers, after intracytoplasmic sperm injection (ICSI) cycles.

Methods: This prospective descriptive cohort study retrieved data from 162 couples who underwent their first ICSI cycles at the Center for Reproductive Endocrinology and Infertility of Hue University Hospital in Vietnam from May 2018 to December 2019. General characteristics, semen parameters, sperm DNA fragmentation index (DFI), fertilization, embryo development, pregnancy rates, and EPL were assessed. Read More

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Successful Vaginal Delivery after External Cephalic Version in a Woman with a Large Partial Uterine Septum.

Case Rep Obstet Gynecol 2021 19;2021:9912271. Epub 2021 May 19.

LAC+USC Medical Center, 2020 Zonal Avenue, IRD Room 533, Los Angeles, CA 90033, USA.

Septate uteri have been associated with adverse pregnancy outcomes including spontaneous abortion, preterm delivery, and malpresentation. It is unclear if uterine septa are associated with infertility. Although some studies have shown improved pregnancy outcomes after septum resection, indications for resection are not well established. Read More

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Low chorionic villous succinate accumulation associates with recurrent spontaneous abortion risk.

Nat Commun 2021 06 8;12(1):3428. Epub 2021 Jun 8.

Clinical and Translational Research Center, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai, China.

Dysregulated extravillous trophoblast invasion and proliferation are known to increase the risk of recurrent spontaneous abortion (RSA); however, the underlying mechanism remains unclear. Herein, in our retrospective observational case-control study we show that villous samples from RSA patients, compared to healthy controls, display reduced succinate dehydrogenase complex iron sulfur subunit (SDHB) DNA methylation, elevated SDHB expression, and reduced succinate levels, indicating that low succinate levels correlate with RSA. Moreover, we find high succinate levels in early pregnant women are correlated with successful embryo implantation. Read More

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Georgian Med News 2021 Apr(313):57-60

Tbilisi State Medical University, JSC Chachava Clinic, Georgia.

Objective of the study - to identify the relationship of immunological parameters and their role in termination of pregnancy. 28 women, with a history of 2 or more miscarriages in their medical history, were examined immediately after the termination of pregnancy up to 12 weeks. The control group consisted of 20 healthy non-pregnant women. Read More

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An integrated approach to uncover quality markers of stir-baking Semen Cuscuta with salt solution preventing recurrent spontaneous abortion based on chemical and metabolomic profiling.

J Chromatogr B Analyt Technol Biomed Life Sci 2021 May 11;1177:122727. Epub 2021 May 11.

Key Laboratory of Chinese Medicinal Formula of Anhui Province, Anhui University of Chinese Medicine, Hefei 230031, PR China; Anhui Province Key Laboratory of Traditional Chinese Medicine Decoction Pieces of New Manufacturing Technology, Bozhou 236800, PR China; Anhui Province Key Laboratory of Research & Development of Chinese Medicine, Hefei 230012, PR China. Electronic address:

The previous research of clinical big data mining showed that stir-baking Semen Cuscuta with salt solution (YP) ranked the first in the usage rate of treating abortion caused by kidney deficiency. At the same time, pharmacodynamic studies also showed that YP has better effect on improving recurrent spontaneous abortion (RSA) compared to raw products of Semen Cuscuta (SP). However, there were few studies on the biomarkers of YP improving RSA. Read More

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Clinical effect of lymphocyte immunotherapy on patients with unexplained recurrent spontaneous abortion.

Immun Inflamm Dis 2021 Jun 8. Epub 2021 Jun 8.

Research Experimental Center, Meizhou People's Hospital (Huangtang Hospital), Meizhou Hospital Affiliated to Sun Yat-sen University, Meizhou, China.

Introduction: Lymphocyte immunotherapy (LIT) is believed to be a viable treatment for unexplained recurrent spontaneous abortion (URSA), but its effect remains controversial. This study aims to investigate the clinical effect of LIT in patients with URSA and clarify the factors that may influence the outcome of LIT.

Methods: This study included a total of 704 URSA patients, of which 444 patients accepted LIT treatment. Read More

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The Role of Immune Cells in Recurrent Spontaneous Abortion.

Reprod Sci 2021 Jun 8. Epub 2021 Jun 8.

Departments of Cardiovascular Medicine, First Hospital, Jilin University, Changchun, 130000, China.

Recurrent spontaneous abortion affects approximately 1-2% of women of childbearing, and describes a condition in which women suffer from three or more continuous spontaneous miscarriages. However, the origin of recurrent spontaneous abortion (RSA) remains unknown, preventing effective treatment and placing stress upon patients. It has been acknowledged that successful pregnancy necessitates balanced immune responses. Read More

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Association Between Prenatal Opioid Exposure and Neurodevelopmental Outcomes in Early Childhood: A Retrospective Cohort Study.

Drug Saf 2021 Jun 7. Epub 2021 Jun 7.

Department of Neurology and Neurological Sciences, Stanford University School of Medicine, California, CA, USA.

Introduction: Several studies have reported increasing prevalence of prescription opioid use among pregnant women. However, little is known regarding the effects of maternal opioid use on neurodevelopmental disorders in early childhood in pregnant women with no evidence of opioid use disorders or drug dependence.

Objective: The aim of this study was to quantify the association between prenatal opioid exposure from maternal prescription use and neurodevelopmental outcomes in early childhood. Read More

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[Application of copy number variation sequencing combined with short tandem repeat in analysis of abortion and prenatal diagnosis].

Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2021 Jun;38(6):577-580

Center of Prenatal Diagnosis, Ma'anshan Maternal and Child Health Care Hospital, Ma'anshan, Anhui 243011, China.

Objective: To explore the cause of abortion and strategy of prenatal diagnosis for pregnant women with high risk for chromosomal abnormalities by using copy number variation sequencing (CNV-seq) and short tandem repeats (STR) analysis.

Methods: A total of 36 samples were collected, including amniotic fluid, abortion tissue, whole blood, chorionic villi and umbilical cord blood. CNV-seq and STR analysis were carried out to detect microdeletions, microduplications, chromosomal aneuploidies, mosaicisms and triploidies. Read More

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Validation of an ICD-10-based algorithm to identify stillbirth in the Sentinel System.

Pharmacoepidemiol Drug Saf 2021 Jun 4. Epub 2021 Jun 4.

Office of Surveillance and Epidemiology, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, USA.

Purpose: To develop and validate an International Classification of Diseases, 10th Revision, Clinical Modification (ICD-10-CM)-based algorithm to identify cases of stillbirth using electronic healthcare data.

Methods: We conducted a retrospective study using claims data from three Data Partners (healthcare systems and insurers) in the Sentinel Distributed Database. Algorithms were developed using ICD-10-CM diagnosis codes to identify potential stillbirths among females aged 12-55 years between July 2016 and June 2018. Read More

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Association between Physiological Equivalent Temperature (PET) with adverse pregnancy outcomes in Ahvaz, southwest of Iran.

BMC Pregnancy Childbirth 2021 Jun 4;21(1):415. Epub 2021 Jun 4.

Department of Epidemiology and Biostatistics, Menopause Andropause Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Background: There are few epidemiological studies on the relation between temperature changes and adverse pregnancy outcomes. The purpose of this study was to determine the relation between Physiological Equivalent Temperature (PET) with adverse pregnancy outcomes including stillbirth, low birth weight (LBW), preterm labor (PTL), spontaneous abortion (SA), preeclampsia and hypertension in Ahvaz, Iran.

Methods: Distributed Lag Non-linear Models (DLNM) combined with quasi-Poisson regression were used to investigate the effect of PET on adverse pregnancy outcomes. Read More

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Decidual NR2F2-Expressing CD4 T Cells Promote TH2 Transcriptional Program During Early Pregnancy.

Front Immunol 2021 18;12:670777. Epub 2021 May 18.

Laboratory for Reproductive Immunology, NHC Key Lab of Reproduction Regulation (Shanghai Institute of Planned Parenthood Research), Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Hospital of Obstetrics and Gynecology, Fudan University Shanghai Medical College, Shanghai, China.

A unique immunotolerant microenvironment with Th2 bias in the decidua provides an essential security for successful pregnancy. The disorganized maternal-fetal immune tolerance contributes to more than 50% of unexplained recurrent spontaneous abortion (RSA). How the Th2 bias is developed at the maternal-fetal interface remains undefined. Read More

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Pain in right buttock after carbon monoxide poisoning.

Huijun Hu Qiang Sun

BMJ 2021 06 3;373:n1233. Epub 2021 Jun 3.

Department of Hyperbaric Oxygen, Sixth Medical Center, Chinese PLA General Hospital, Beijing, China.

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Seasonal influenza vaccine exposure in pregnancy: 5-year results from a pregnancy registry.

Ugo Nwoji

Hum Vaccin Immunother 2021 Jun 3:1-6. Epub 2021 Jun 3.

GlaxoSmithKline, Rockville, MD, USA.

The World Health Organization recommends that all pregnant women receive seasonal influenza vaccine. Under a post-authorization safety study protocol (NCT02148211), a pregnancy exposure registry was established in the United States to monitor spontaneously reported pregnancy outcomes in women vaccinated with GSK's seasonal inactivated influenza vaccines (IIVs). From 1 June 2014 to 31 May 2019, 507 pregnancies were prospectively reported: 352 (69. Read More

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The Impact of Preconceptional Hysterosalpingography with Oil-based Contrast on Maternal and Neonatal Iodine Status.

Reprod Sci 2021 Jun 2. Epub 2021 Jun 2.

Beijing Key Laboratory of the Innovative Development of Functional Staple and the Nutritional Intervention for Chronic Disease, Department of Clinical Nutrition, Peking Union Medical College Hospital (PUMCH), No. 1 in Shuaifuyuan Street, Dongdan Street, Dongcheng District, Beijing, 100730, China.

The objective of this study is to investigate the impact of preconceptional exposure to oil-based iodinated contrast in the hysterosalpingography (HSG) on pregnant women and their offspring's iodine status, thyroid function, and the outcomes of pregnancy. A cross-sectional evaluation of iodine status was performed on pregnant women with the preconceptional experience of ethiodized-oil HSG. For those found to have iodine excess (with serum iodine concentration (SIC) > 92 μg/L), a prospective follow-up was conducted until termination of the pregnancy or 1 week postpartum. Read More

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New Insights into Vaginal Environment During Pregnancy.

Front Mol Biosci 2021 17;8:656844. Epub 2021 May 17.

Microbiology, DIMES, University of Bologna, Bologna, Italy.

During pregnancy, the vaginal ecosystem undergoes marked changes, including a significant enrichment with spp. and profound alterations in metabolic profiles. A deep comprehension of the vaginal environment may shed light on the physiology of pregnancy and may provide novel biomarkers to identify subjects at risk of complications (e. Read More

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Early Embryonic Loss Following Intravaginal Zika Virus Challenge in Rhesus Macaques.

Front Immunol 2021 17;12:686437. Epub 2021 May 17.

Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, WI, United States.

Zika virus (ZIKV) is an arthropod-borne virus (arbovirus) and is primarily transmitted by species mosquitoes; however, ZIKV can also be sexually transmitted. During the initial epidemic and in places where ZIKV is now considered endemic, it is difficult to disentangle the risks and contributions of sexual versus vector-borne transmission to adverse pregnancy outcomes. To examine the potential impact of sexual transmission of ZIKV on pregnancy outcome, we challenged three rhesus macaques () three times intravaginally with 1 x 10 PFU of a low passage, African lineage ZIKV isolate (ZIKV-DAK) in the first trimester (~30 days gestational age). Read More

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Variation in inferior vena cava diameter as an early marker in postpartum hemorrhage.

Ultrasound Obstet Gynecol 2021 Jun 2. Epub 2021 Jun 2.

Department of Obstetrics and Gynecology, Emek Medical Center, Afula, Israel.

Objective: To examine the association between IVC diameter and postpartum blood loss and whether the variations in IVC diameter, if present, stands as a useful marker in diagnosis of postpartum blood loss.

Materials And Methods: Prospective case control study was conducted in a University Teaching Medical Center in Afula, Israel, between November, 2018 and March, 2020. The study cohort consisted of women with singleton pregnancy that delivered vaginally at term. Read More

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An abortion storm in dairy cattle associated with neosporosis in southern Brazil.

Rev Bras Parasitol Vet 2021 28;30(2):e001821. Epub 2021 May 28.

Departamento de Medicina Veterinária, Setor de Ciências Agrárias, Universidade Federal do Paraná - UFPR, Curitiba, PR, Brasil.

Between December 2016 and April 2017, a spate of abortions occurred in a closed dairy herd from the central eastern region of Paraná, Brazil, in which 75 cows aborted. To identify its cause, organ fragments were collected from an aborted fetus for histopathology, and the blood samples from a stillborn, 4 aborted fetuses, and 9 farm dogs for indirect fluorescent antibody technique (IFAT). These tests found multifocal non-suppurative encephalitis, periportal hepatitis, and multifocal lymphoplasmacytic myocarditis, and detected anti-Neospora antibodies in all aborted fetuses, and in 5 of the 9 dogs. Read More

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Loss of p57 Expression in Conceptions Other Than Complete Hydatidiform Mole: A Case Series With Emphasis on the Etiology, Genetics, and Clinical Significance.

Am J Surg Pathol 2021 Jun 2. Epub 2021 Jun 2.

Departments of Pathology Gynecology and Obstetrics Oncology, The Johns Hopkins Medical Institutions, Baltimore, MD.

Combined p57 immunohistochemistry and DNA genotyping refines classification of products of conception specimens into specific types of hydatidiform moles and various nonmolar entities that can simulate them. p57 expression is highly correlated with genotyping and in practice can reliably be used to identify virtually all complete hydatidiform moles (CHM), but aberrant retained or lost p57 expression in rare CHMs and partial hydatidiform moles (PHM), as well as loss in some nonmolar abortuses, has been reported. Among a series of 2329 products of conceptions, we identified 10 cases for which loss of p57 expression was inconsistent with genotyping results (none purely androgenetic). Read More

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First-trimester miscarriage rate decreases with hydralazine therapy in pregnancies with early uterine vascular insufficiency: a cohort study.

J Matern Fetal Neonatal Med 2021 Jun 1:1-10. Epub 2021 Jun 1.

FETALMED - Maternal-Fetal Diagnostic Center, Santiago, Chile.

Background: Miscarriage is the most frequent cause of pregnancy loss, affecting 15-20% of clinically recognized pregnancies. Early uterine vascular insufficiency (EUVI), defined as abnormal uterine artery (UA) Doppler impedance indices in early pregnancy, is present in two-thirds of pregnancies ending in miscarriage after embryonic cardiac activity has been detected. There is currently no available therapy for reducing the risk of miscarriage in these cases. Read More

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The Immunological Role of the Placenta in SARS-CoV-2 Infection-Viral Transmission, Immune Regulation, and Lactoferrin Activity.

Int J Mol Sci 2021 May 28;22(11). Epub 2021 May 28.

Department of Animal Nutrition, The Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences, Instytucka 3, 05-110 Jabłonna, Poland.

A pandemic of acute respiratory infections, due to a new type of coronavirus, can cause Severe Acute Respiratory Syndrome 2 (SARS-CoV-2) and has created the need for a better understanding of the clinical, epidemiological, and pathological features of COVID-19, especially in high-risk groups, such as pregnant women. Viral infections in pregnant women may have a much more severe course, and result in an increase in the rate of complications, including spontaneous abortion, stillbirth, and premature birth-which may cause long-term consequences in the offspring. In this review, we focus on the mother-fetal-placenta interface and its role in the potential transmission of SARS-CoV-2, including expression of viral receptors and proteases, placental pathology, and the presence of the virus in neonatal tissues and fluids. Read More

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Essential Role of CRIM1 on Endometrial Receptivity in Goat.

Int J Mol Sci 2021 May 18;22(10). Epub 2021 May 18.

Department of Clinical Veterinary Medicine, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, China.

In domestic ruminants, endometrial receptivity is related to successful pregnancy and economic efficiency. Despite several molecules having been reported in the past regarding endometrial receptivity regulation, much regarding the mechanism of endometrial receptivity regulation remains unknown due to the complex nature of the trait. In this work, we demonstrated that the cysteine-rich transmembrane bone morphogenetic protein (BMP) regulator 1 (CRIM1) served as a novel regulator in the regulation of goat endometrial receptivity in vitro. Read More

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