44,112 results match your criteria Early Pregnancy Loss


Prebiotic Oligofructose Prevents Antibiotic-Induced Obesity Risk and Improves Metabolic and Gut Microbiota Profiles in Rat Dams and Offspring.

Mol Nutr Food Res 2020 Jul 1:e2000288. Epub 2020 Jul 1.

T. Klancic, A. Choo, J. E. Nettleton, F. Chleilat, E. W. Noye Tuplin, E. Alukic, N. A. Cho, A. C. Nicolucci, R. A. Reimer, Faculty of Kinesiology, University of Calgary, Calgary, AB, T2N 1N4, Canada.

Scope: Antibiotics in early life disrupt microbiota and increase obesity risk, whereas dietary agents such as prebiotics may reduce obesity risk. We examined how antibiotics administered with/without prebiotic oligofructose, alter metabolic and microbial outcomes in pregnant rats and their offspring.

Methods And Results: Pregnant rats were randomized to: 1) Control [CTR], 2) Antibiotic [ABT], 3) Prebiotic [PRE], 4) Antibiotic+Prebiotic [ABT+PRE] during the 3rd week of pregnancy and lactation. Read More

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http://dx.doi.org/10.1002/mnfr.202000288DOI Listing

The SARS-CoV-2 receptor, Angiotensin converting enzyme 2 (ACE2) is required for human endometrial stromal cell decidualization.

bioRxiv 2020 Jun 24. Epub 2020 Jun 24.

Study Question: Is SARS-CoV-2 receptor, angiotensin-converting enzyme 2 (ACE 2) expressed in the human endometrium during the menstrual cycle, and does it participate in endometrial decidualization?

Summary Answer: ACE2 protein is highly expressed in human endometrial stromal cells during the secretory phase and is essential for human endometrial stromal cell decidualization.

What Is Known Already: ACE2 is expressed in numerous human tissues including the lungs, heart, intestine, kidneys and placenta. ACE2 is also the receptor by which SARS-CoV-2 enters human cells. Read More

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http://dx.doi.org/10.1101/2020.06.23.168252DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7325175PMC

Effects of Testosterone on the Expression of Connexin 26 and Connexin 43 in the Uterus of Rats During Early Pregnancy.

In Vivo 2020 Jul-Aug;34(4):1863-1870

Department of Physiology, Faculty of Medicine, Universiti Kebangsaan Malaysia (UKM), Kuala Lumpur, Malaysia

Background/aim: It was hypothesized that testosterone could affect the distribution and expression of connexin 26 and connexin 43 in the uterus. Thus, the effects of testosterone on these parameters in the uterus during the uterine receptivity period were investigated.

Materials And Methods: Intact pregnant rats were administered 1 mg/kg/day testosterone alone or in combination with flutamide, finasteride or anastrozole, subcutaneously on day-1 of pregnancy till day 3. Read More

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http://dx.doi.org/10.21873/invivo.11981DOI Listing

[Unsolved issues of pregnancy in liver cirrhosis].

Ter Arkh 2019 Apr 15;91(4):114-117. Epub 2019 Apr 15.

Obstetric Clinic, University Hospital "Dr. Georgi Stranski", Department of obstetrics and gynecology, Medical University.

Pregnancy in patients with liver cirrhosis and portal hypertension occurs very rare, because of their significantly derailed reproductive functions. Тhe risks for the mother and the fetus are connected with worsening of the portal hypertension, progression of decompensated liver cirrhosis and development of its complications: liver failure, ascites, hepatorenal syndrome, hepatic encephalopathy and variceal hemorrhage, and with increased incidence of spontaneous abortions and abnormal uterine bleeding. The decision for continuation of the pregnancy in cirrhotic patients must be based on individual approach and a multidisciplinary team consisting of obstetricians, hepatologists, anesthesiologists, surgeons and hematologists must participate in the therapy. Read More

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http://dx.doi.org/10.26442/00403660.2019.04.000145DOI Listing

Tregitopes regulate the tolerogenic immune response and decrease the foetal death rate in abortion-prone mouse matings.

Sci Rep 2020 Jun 29;10(1):10531. Epub 2020 Jun 29.

Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wroclaw, Poland.

The imbalance in immune tolerance may cause the variety of reproductive failures. An intravenous immunoglobulin infusion (IVIg) therapy is used to improve the live birth rate in women suffering from recurrent pregnancy loss, recurrent spontaneous abortions and recurrent implantation failures. However, the results of IVIg studies are still inconclusive as IVIg infusion in women suffering from pregnancy loss is sometimes ineffective. Read More

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http://dx.doi.org/10.1038/s41598-020-66957-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7324366PMC

Single Cell Collection of Trophoblast Cells in Peri-implantation Stage Human Embryos.

J Vis Exp 2020 Jun 12(160). Epub 2020 Jun 12.

Colorado Center for Reproductive Medicine;

Human implantation, the apposition and adhesion to the uterine surface epithelia and subsequent invasion of the blastocyst into the maternal decidua, is a critical yet enigmatic biological event that has been historically difficult to study due to technical and ethical limitations. Implantation is initiated by the development of the trophectoderm to early trophoblast and subsequent differentiation into distinct trophoblast sublineages. Aberrant early trophoblast differentiation may lead to implantation failure, placental pathologies, fetal abnormalities, and miscarriage. Read More

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http://dx.doi.org/10.3791/61476DOI Listing

Physical Exam Indicated Cerclage in Twin pregnancy: a Randomized Controlled Trial.

Am J Obstet Gynecol 2020 Jun 24. Epub 2020 Jun 24.

Maternal Fetal Medicine Division, Obstetrics and Gynecology Department, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, PA, United States.

Background: Twin pregnancies with dilated cervix in the second trimester are at increased risk of pregnancy loss and early preterm birth; currently there is no proven therapy to prevent preterm birth in this group of women.

Objective: To determine if physical exam indicated cerclage reduces the incidence of preterm birth in asymptomatic women with twin gestations and cervical dilation diagnosed before 24 weeks of pregnancy.

Study Design: Multicenter, parallel-group, open-label, randomized controlled trial of women with twin pregnancy, and asymptomatic cervical dilation from 1-5 cm between 16 0/7 to 23 6/7 weeks were enrolled from 7/2015 to 7/2019 in 8 centers. Read More

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http://dx.doi.org/10.1016/j.ajog.2020.06.047DOI Listing

Reproductive health of Roma women in Slovakia.

Cent Eur J Public Health 2020 Jun;28(2):143-148

Regional Authority of Public Health, Banska Bystrica, Slovakia.

Objective: In most indicators of the way of life, the Roma community is generally different from the majority population and dominant culture. The objective of the study was to describe factors affecting the health of the Roma living in Slovakia, with an emphasis on the sexual and reproductive health of Roma women, and report on the results of analysis of high-risk pregnancies of Roma women in the district of Rimavská Sobota, Slovakia.

Methods: A retrospective study of medical documentation was used. Read More

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http://dx.doi.org/10.21101/cejph.a5817DOI Listing

Expectant management and live birth outcomes for male balanced-translocation carriers: Two case reports and a literature review.

Medicine (Baltimore) 2020 Jun;99(26):e20894

Rationale: Couples with male balanced-translocation carriers may experience recurrent pregnancy loss (RPL). Although the expectant management of RPL has developed over many years, genetic counseling for RPL couples with male balanced-translocation carriers remains challenging. Here, we describe the expectant management of 2 male carriers of balanced translocations. Read More

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http://dx.doi.org/10.1097/MD.0000000000020894DOI Listing

Adiponectin Reduces Embryonic Loss Rate and Ameliorates Trophoblast Apoptosis in Early Pregnancy of Mice with Polycystic Ovary Syndrome by Affecting the AMPK/PI3K/Akt/FoxO3a Signaling Pathway.

Reprod Sci 2020 Jun 25. Epub 2020 Jun 25.

Department of Reproductive Medicine, The First Affiliated Hospital, Jinan University, 601 West Huangpu Avenue, Guangzhou, 510000, Guangdong, People's Republic Of China.

Reports in recent years have suggested that adiponectin (APN) improves insulin resistance and inhibits apoptosis by activating the AMP-activated protein kinase (AMPK) pathway and the PI3K/Akt signaling pathway after binding to its receptor. This study aims to explore the mechanism by which APN reduces embryo loss rate and trophoblast apoptosis in early pregnancy of mice with polycystic ovary syndrome (PCOS). PCOS mice were subcutaneously injected with APN (10 μg mg kg day) on 11 consecutive days from the 3rd day of pregnancy onwards to observe the change of the embryo loss rate of PCOS mice induced by APN. Read More

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http://dx.doi.org/10.1007/s43032-020-00237-zDOI Listing

Utilization of Whole Exome Sequencing in Lethal Form of Multiple Pterygium Syndrome: Identification of Mutations in Embryonal Subunit of Acetylcholine Receptor.

Int J Mol Cell Med 2019 ;8(4):258-269

Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.

The acetylcholine receptor (AChR) is a member of the superfamily of transmitter-gated ion channels having a critical role in controlling electrical signals between nerves and muscle cells. Disruptive mutations in genes encoding different subunits of AChR result in multiple pterygium syndrome (MPS), which can be associated with a severe prenatally lethal presentation. This study aimed to investigate the etiology of lethal MPS (LMPS) in two consanguineous families with a history of miscarriages. Read More

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http://dx.doi.org/10.22088/IJMCM.BUMS.8.4.258DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7305466PMC
January 2019

Pregnancy Outcomes of Wives of Chemical and Non-Chemical Weapons Exposed Veterans in Ahvaz, Iran: A Retrospective Cohort Study.

Prehosp Disaster Med 2020 Jun 25:1-5. Epub 2020 Jun 25.

Trauma Research Center, Nursing Faculty, Baqiyatallah University of Medical Sciences, Tehran, Iran.

Background: Sulphur mustard (HD) is a lipophilic caustic alkylating vesicant (blister agent) that has mutagenic and carcinogenic effects. Among the studied perturbations are long-term genitourinary (GU) and fertility effects. Approximately 50,000 Iranian soldiers and civilians were exposed to HD during the Iraq-Iran war (1980-1989). Read More

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http://dx.doi.org/10.1017/S1049023X2000076XDOI Listing

GENETICS IN ENDOCRINOLOGY Pathophysiology, diagnosis and treatment of familial nephrogenic diabetes insipidus.

Authors:
Daniel G Bichet

Eur J Endocrinol 2020 Aug;183(2):R29-R40

For an endocrinologist, nephrogenic diabetes insipidus (NDI) is an end-organ disease, that is the antidiuretic hormone, arginine-vasopressin (AVP) is normally produced but not recognized by the kidney with an inability to concentrate urine despite elevated plasma concentrations of AVP. Polyuria with hyposthenuria and polydipsia are the cardinal clinical manifestations of the disease. For a geneticist, hereditary NDI is a rare disease with a prevalence of five per million males secondary to loss of function of the vasopressin V2 receptor, an X-linked gene, or loss of function of the water channel AQP2. Read More

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http://dx.doi.org/10.1530/EJE-20-0114DOI Listing

A method to visualize a complete sensitivity analysis for loss to follow-up in clinical trials.

Contemp Clin Trials Commun 2020 Sep 9;19:100586. Epub 2020 Jun 9.

Epidemiology Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD, United States.

Loss to follow-up occurs in randomized controlled trials. Missing data methods, including multiple imputation (MI), can be used but often rely upon untestable assumptions. Sensitivity analysis can quantify violations of these assumptions. Read More

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http://dx.doi.org/10.1016/j.conctc.2020.100586DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7300145PMC
September 2020

Uncontrolled Acute Intermittent Porphyria as a Cause of Spontaneous Abortion.

Med Arch 2020 Apr;74(2):153-155

Clinic for Urology, University Clinical Center Tuzla, Tuzla, Bosnia and Herzegovina.

Introduction: The association of acute intermitetn porphyria (AIP) with pregnancy and as a cause of spontaneous abortion is rare.

Aim: To show a case of AIP known before pregnancy in a patient who had a spontaneous abortion.

Case Report: A gynecologist examined 26-year-old patient in the 8th week of gestation, due to initial spontaneous abortion, abdominal pain, constipation, muscle weakness, vomiting and dark colour of urine. Read More

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http://dx.doi.org/10.5455/medarh.2020.74.153-155DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7296395PMC

Lymphocyte Activation in the Development of Immune Tolerance in Women with Recurrent Pregnancy Loss.

Biochemistry (Mosc) 2020 May;85(5):583-593

National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Healthcare of the Russian Federation, Moscow, 117997, Russia.

Association between lymphocyte activation and formation of immune tolerance, as well as pregnancy outcome, in the case of immunocytotherapy (ICT) was studied in women with idiopathic recurrent pregnancy loss (IRPL). The content and phenotypic characteristics of activated T lymphocytes and NK cells were investigated in the peripheral blood of IRPL patients with different pregnancy outcomes (pregnancy prolongation to the full term and habitual miscarriage). The fraction of activated cells in the subpopulation of cytotoxic T lymphocytes (CD3CD8/CD3CD8CD69) before ICT was significantly lower in women who lost the pregnancy. Read More

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http://dx.doi.org/10.1134/S0006297920050077DOI Listing

Treatment with an elevated dose of the GnRH analogue dephereline in the early luteal phase improves pregnancy rates in repeat-breeder dairy cows.

Theriogenology 2020 Jun 12;155:12-16. Epub 2020 Jun 12.

Transfer in Bovine Reproduction SLu, 22300, Barbastro, Spain; Department of Animal Science, University of Lleida, 25198, Lleida, Spain.

This study sought to establish whether treatment with the GnRH analog dephereline in the early luteal phase could be useful to improve fertility in repeat-breeder cows (>3 inseminations). Dephereline was given 5-7 days after insemination, and effects of both a single and elevated (2.5 times) dephereline dose on pregnancy and subsequent embryo survival determined in repeat-breeder lactating dairy cows. Read More

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http://dx.doi.org/10.1016/j.theriogenology.2020.06.011DOI Listing

Pregnancy outcomes of women conceiving on antiretroviral therapy (ART) compared to those commenced on ART during pregnancy.

Clin Infect Dis 2020 Jun 20. Epub 2020 Jun 20.

Johns Hopkins University, Department of Pathology, Baltimore, MD, USA.

Background: Globally, the number of HIV-infected women of child-bearing age conceiving on ART is increasing. Evidence of ART safety at conception and during pregnancy and adverse pregnancy outcomes remains conflicting. The PROMISE 1077 breastfeeding (BF) and formula feeding (FF) international multisite trials provide an opportunity to examine the impact of ART at conception on pregnancy outcomes with subsequent pregnancies. Read More

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http://dx.doi.org/10.1093/cid/ciaa805DOI Listing
June 2020
8.886 Impact Factor

Miscarriage information available on the internet: a content analysis of leading consumer websites.

Contracept X 2019 5;1:100010. Epub 2019 Oct 5.

Advancing New Standards in Reproductive Health (ANSIRH), Bixby Center for Global Reproductive Health, Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco.

Objective: The objective of this content analysis was to explore the accuracy and completeness of information provided about miscarriage on consumer-facing websites.

Study Design: We identified the most popular consumer websites for health information and the leading medical and nursing professional association websites. We reviewed each website for content on miscarriage aimed at consumers and compared the website content to the information contained in the American College of Obstetricians and Gynecologists (ACOG) Practice Bulletin on Early Pregnancy Loss. Read More

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http://dx.doi.org/10.1016/j.conx.2019.100010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7286151PMC
October 2019

The Effect of Brief Supportive Psychotherapy on Prevention of Psychiatric Morbidity in Women with Miscarriage: A Randomized Controlled Trial about the First 24-hours of Hospitalization.

Oman Med J 2020 May 15;35(3):e130. Epub 2020 Jun 15.

Department of Obstetrics and Gynecology, Cancer Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran.

Objectives: Miscarriage is a common pregnancy complication causing substantial psychiatric complications. This study was designed to investigate whether the administration of brief supportive psychotherapy (BSP) is effective on the management of women with miscarriage when conducted in the first 24 hours of hospitalization in order to prevent symptoms of anxiety, depression, and grief at four-months post-miscarriage.

Methods: We conducted a randomized clinical trial on 79 women with miscarriage hospitalized in Ayatollah Rohani teaching hospital. Read More

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http://dx.doi.org/10.5001/omj.2020.48DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7294535PMC

MiR-103 protects from recurrent spontaneous abortion via inhibiting STAT1 mediated M1 macrophage polarization.

Int J Biol Sci 2020 25;16(12):2248-2264. Epub 2020 May 25.

Laboratory for Molecular Immunology, Institute of Basic Medicine, Shandong Provincial Hospital Affiliated to Shandong First Medical University, 18877 Jingshi Road, Jinan 250062, Shandong, China.

Recurrent spontaneous abortion (RSA) is a common complication of early pregnancy. Excessive M1 macrophage was found to be involved in RSA, but the underlying mechanisms remains unclear. MicroRNAs play critical roles in RSA as well as the polarization of macrophages; however, the regulatory effect of miRNAs on M1 differentiation in RSA has not been fully investigated. Read More

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http://dx.doi.org/10.7150/ijbs.46144DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7294935PMC

The Incidence of Pregnancy-Associated Cushing's Disease and Its Relation to Pregnancy: A Retrospective Study.

Front Endocrinol (Lausanne) 2020 29;11:305. Epub 2020 May 29.

Key Laboratory of Endocrinology of National Health Commission, Department of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China.

Cushing's disease (CD) is one of the most severe endocrine disorders and primarily affects women of reproductive age. The peripartum period has been observed to be a common time to develop CD. This study aims to retrospectively analyze the clinical characteristics of CD potentially associated with pregnancy and to evaluate relevant pregnancy outcomes. Read More

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http://dx.doi.org/10.3389/fendo.2020.00305DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7272570PMC

Lithium Use during Pregnancy and the Risk of Miscarriage.

J Clin Med 2020 Jun 11;9(6). Epub 2020 Jun 11.

Department of Psychiatry, Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands.

Recent studies have provided new data on the teratogenicity of lithium. Less is known about the risk of miscarriage after lithium use during pregnancy. The aim of this study was to investigate the association between lithium use during pregnancy and miscarriage. Read More

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http://dx.doi.org/10.3390/jcm9061819DOI Listing

Folic acid content of diet during pregnancy determines post-birth re-set of metabolism in Wistar rat dams.

J Nutr Biochem 2020 May 16;83:108414. Epub 2020 May 16.

Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, ON, Canada; Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, ON, Canada. Electronic address:

Maternal metabolism begins to return to homeostasis (re-set) following birth and is accelerated by lactation. Delay in metabolic re-set may contribute to postpartum weight retention and later-life metabolic consequences. Folic acid (FA) is essential during pregnancy but inadequate intakes may alter 1-carbon metabolism, consequently affecting energy homeostatic systems. Read More

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http://dx.doi.org/10.1016/j.jnutbio.2020.108414DOI Listing
May 2020
3.794 Impact Factor

Polypoid endometriosis of the rectum and vagina in an adolescent.

J Pediatr Adolesc Gynecol 2020 Jun 13. Epub 2020 Jun 13.

Department of Critical Care Medicine, Shenzhen People's Hospital, 2nd Clinical Medical College of Jinan University, 1st Affiliated Hospital of Southern University of Science and Technology, Shenzhen, China. Electronic address:

Background: Polypoid endometriosis (PEM) is a rare type of endometriosis, frequently mimicking a malignant tumor. We reported a 10-year span case of PEM who had symptoms at age 16.

Case: A 20-year-old woman presented with massive vaginal hemorrhage and spontaneous abortion, having symptoms of dysmenorrhea, anal distending pain, and vaginal bleeding since adolescence. Read More

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http://dx.doi.org/10.1016/j.jpag.2020.06.006DOI Listing

Severe Coronavirus Infections in Pregnancy: A Systematic Review.

Obstet Gynecol 2020 Jun 16. Epub 2020 Jun 16.

Division of Reproductive Health and the Division of Birth Defects and Infant Disorders, Centers for Disease Control and Prevention, and the Department of Gynecology & Obstetrics, Emory University School of Medicine, Atlanta, Georgia.

Objective: To inform the current coronavirus disease 2019 (COVID-19) outbreak, we conducted a systematic literature review of case reports of Middle East respiratory syndrome coronavirus (MERS-CoV), severe acute respiratory syndrome coronavirus (SARS-CoV), and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes COVID-19, during pregnancy and summarized clinical presentation, course of illness, and pregnancy and neonatal outcomes.

Data Sources: We searched MEDLINE and ClinicalTrials.gov from inception to April 23, 2020. Read More

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http://dx.doi.org/10.1097/AOG.0000000000004011DOI Listing

The Role of the IL-1 System in Pregnancy and the Use of IL-1 System Markers to Identify Women at Risk for Pregnancy Complications†.

Biol Reprod 2020 Jun 16. Epub 2020 Jun 16.

University of Geneva, Switzerland.

The interleukin (IL)-1 system plays a major role in immune responses and inflammation. The IL-1 system components include IL-1α, IL-1β, IL-1 receptor type 1 and IL-1 receptor type 2 (decoy receptor), IL-1 receptor accessory protein (IL-1RAcP), and IL-1 receptor antagonist (IL-1Ra). These components have been shown to play a role in pregnancy, specifically in embryo-maternal communication for implantation, placenta development, and protection against infections. Read More

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http://dx.doi.org/10.1093/biolre/ioaa102DOI Listing

Current situation and outcomes of pregnancy in women with Turner syndrome in Japan.

J Obstet Gynaecol Res 2020 Jun 16. Epub 2020 Jun 16.

Department of Gynecology, Yokohama City University Medical Center, Yokohama, Japan.

Aim: Reports on pregnancy and delivery in women with Turner syndrome (TS) in Japan are limited to case reports, and the current situation remains unclear. Therefore, this study aimed to clarify the current situation of pregnancy and delivery in women with TS in Japan.

Methods: Our study comprised primary and secondary surveys and we included perinatal centers approved by the Ministry of Health, Labor and Welfare. Read More

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http://dx.doi.org/10.1111/jog.14352DOI Listing

Pregnancy outcome following first-trimester exposure to fingolimod: A collaborative ENTIS study.

Mult Scler 2020 Jun 15:1352458520929628. Epub 2020 Jun 15.

Swiss Teratogen Information Service, Service de Pharmacologie Clinique, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.

This prospective multicentre cohort study investigated pregnancy outcomes after fingolimod use for multiple sclerosis during pregnancy. Pregnancy outcomes of 63 fingolimod and 62 interferon-β-exposed pregnancies were compared. Rates of major congenital anomalies (MCA) were 4. Read More

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http://dx.doi.org/10.1177/1352458520929628DOI Listing

Long-term follow-up of antiphospholipid syndrome: real-life experience from a single center.

Lupus 2020 Jun 14:961203320933009. Epub 2020 Jun 14.

Department of Autoimmune Diseases, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), University of Barcelona, Barcelona, Catalonia, Spain.

Objective: The objective of this paper is to assess the prevalence of the main clinical manifestations and laboratory features at disease onset and during the ensuing 10 years of a large cohort of patients with antiphospholipid syndrome (APS) from a single center.

Methods: The study included all consecutive APS patients followed longitudinally in our center from 2003 to 2013. Descriptive statistics for demographics, clinical and laboratory features and mortality were performed. Read More

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http://dx.doi.org/10.1177/0961203320933009DOI Listing

Meta-analysis of heparin combined with aspirin versus aspirin alone for unexplained recurrent spontaneous abortion.

Int J Gynaecol Obstet 2020 Jun 13. Epub 2020 Jun 13.

Department of Gynecology and Obstetrics, Tianjin Medical University General Hospital, Tianjin, PR China.

Background: Unexplained recurrent spontaneous abortion (URSA) frustrates women of childbearing age profoundly, and effective therapies are particularly important.

Objective: To compare the efficacy of heparin combined with aspirin and aspirin alone for URSA.

Search Strategy: Electronic databases (PubMed, Medline, Web of Science, Clinical key and Cochrane Library) were searched for relevant studies from database inception to August 2019. Read More

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http://dx.doi.org/10.1002/ijgo.13266DOI Listing

Pre-pregnancy, obstetric and delivery status in women with neuromyelitis optica spectrum disorder.

Mult Scler Relat Disord 2020 Jun 2;44:102252. Epub 2020 Jun 2.

Department of Neurology, Slagelse Hospital, Institute of Regional Health Research, Denmark; Department of Neurobiology, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark. Electronic address:

Background: Neuromyelitis optica spectrum disorder (NMOSD) is a potentially disabling disease which affects predominantly women of reproductive age.

Objectives: To evaluate the pre-pregnancy condition and to investigate the prevalence of obstetrical and neonatal complaints in NMOSD.

Methods: An observational retrospective study of 37 NMOSD patients positive for aquaporin-4-immunoglobulin-IgG. Read More

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http://dx.doi.org/10.1016/j.msard.2020.102252DOI Listing

Sire contribution to pregnancy loss in different periods of embryonic and fetal development of beef cows.

Theriogenology 2020 May 18;154:84-91. Epub 2020 May 18.

Department of Animal Science, Pregnancy and Developmental Programming Area of Excellence, Texas A&M University, College Station, TX, 77843, USA. Electronic address:

The objective was to evaluate the effect of service sire on pregnancy results during different periods of embryonic and fetal development. Angus cows (n = 658) were timed artificially inseminated (TAI) on day 0 after synchronization of estrus using one of eight Angus sires. Estrus expression prior to TAI was evaluated using estrus breeding indicators. Read More

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http://dx.doi.org/10.1016/j.theriogenology.2020.05.021DOI Listing

Gabapentin as an Adjunct to Paracervical Block for Perioperative Pain Management for First Trimester Uterine Aspiration: A Randomized Controlled Trial.

Am J Obstet Gynecol 2020 Jun 11. Epub 2020 Jun 11.

Department of Gynecology and Obstetrics, Emory University, School of Medicine, Atlanta, Georgia, USA.

Background: Pain management approaches during uterine aspiration vary, with methods including local anesthetic, oral analgesics, moderate sedation, deep sedation, or a combination of approaches. For local anesthetic approaches specifically, we continue to have suboptimal pain control [1]. Gabapentin as an adjunct to pain management has proven to be beneficial in gynecological surgery. Read More

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http://dx.doi.org/10.1016/j.ajog.2020.06.011DOI Listing

Serum progesterone level and ongoing pregnancy rate following frozen-thawed embryo transfer after artificial endometrial preparation: a monocentric retrospective study.

J Gynecol Obstet Hum Reprod 2020 Jun 10:101828. Epub 2020 Jun 10.

AP-HP, Unité de Médecine de la Reproduction, Service de Gynécologie-Obstétrique, Hôpital Bichat-Claude Bernard, Paris, France. Electronic address:

Introduction: In some studies, early pregnancy loss (EPL) rate is higher with artificial cycle (AC) endometrial preparation for frozen-thawed embryo (FET) transfer than with other protocols, even though pregnancy rates are similar. An inadequate luteal phase support could explain these findings. The aim of this study was to compare, among the patients who had a pregnancy after FET with AC endometrial preparation, serum progesterone (PG) levels between those who experienced an EPL or an ongoing pregnancy. Read More

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http://dx.doi.org/10.1016/j.jogoh.2020.101828DOI Listing

Outcomes of Prenatally Diagnosed Spontaneous Chorioamniotic Membrane Separation in Singleton Pregnancies: A Systematic Review of Case Series and Case Reports.

Prenat Diagn 2020 Jun 13. Epub 2020 Jun 13.

Department of Obstetrics & Gynecology, Baylor College of Medicine, Houston, Texas, USA.

Objectives: To provide an overview of perinatal outcomes in prenatally diagnosed spontaneous chorioamniotic separation (sCAS).

Methods: A systematic search of the literature was performed from inception to July 2019, including PubMed, Ovid MEDLINE, and Ovid EMBASE. All studies reporting prenatally diagnosed sCAS after 16 weeks' gestation in singleton pregnancies were eligible. Read More

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http://dx.doi.org/10.1002/pd.5767DOI Listing

The earlier the better or the later the better: optimal timing of fetal reduction from twins to singleton.

Ultrasound Obstet Gynecol 2020 Jun 12. Epub 2020 Jun 12.

Department of Obstetrics and Gynecology, Sheba Medical Center, Tel-Hashomer, Israel.

Objectives: The aim of this study was to compare pregnancy complications, obstetric and neonatal outcomes of twin pregnancies that were reduced to singletons at early versus later gestational age.

Methods: From January 2005 through February 2017, 248 dichorionic diamniotic twin pregnancies underwent reduction to singleton in a single tertiary referral center. Fetal reductions performed at 11-14 weeks' gestation were mainly done at the patient's request or as a result of a complicated medical or obstetric history (early reduction, n=172). Read More

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http://dx.doi.org/10.1002/uog.22119DOI Listing

Polo-like kinase 4 and Stromal antigen 3 are not associated with recurrent pregnancy loss caused by embryonic aneuploidy.

Hum Genome Var 2020 29;7:18. Epub 2020 May 29.

Department of Human Genetics, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.

No genetic association with recurrent pregnancy loss (RPL) caused by embryonic aneuploidy has been found. Recent studies have indicated that the common genetic variant rs2305957, surrounding the gene, contributes to mitotic-origin aneuploidy risk during human early embryo development. The decrease in meiosis-specific cohesin causes predivision of sister chromatids in the centromere and chromosome segregation errors. Read More

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http://dx.doi.org/10.1038/s41439-020-0106-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7260232PMC

Long-Lasting Insecticidal Net Utilization and Associated Factors Among Pregnant Women in Asgede Tsimbla District, Northern Ethiopia, 2017.

Environ Health Insights 2020 29;14:1178630220919393. Epub 2020 May 29.

School of Public Health, College of Health Science, Aksum University, Aksum, Ethiopia.

Background: Malaria among pregnant women contributes to maternal anemia, low birth weight, spontaneous abortion, and infant deaths. In response to this serious health problem, regular use of the long-lasting insecticidal net is the most cost-effective method of preventing malaria. However, in most developing countries, including Ethiopia, long-lasting insecticidal net utilization by pregnant women is uncertain. Read More

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http://dx.doi.org/10.1177/1178630220919393DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7263101PMC

Metabolic reprogramming by Zika virus provokes inflammation in human placenta.

Nat Commun 2020 Jun 11;11(1):2967. Epub 2020 Jun 11.

Center for Pathophysiology of Toulouse Purpan, CNRS - Inserm - University of Toulouse, 31024, Toulouse, France.

The recent outbreak of Zika virus (ZIKV) was associated with birth defects and pregnancy loss when maternal infection occurs in early pregnancy, but specific mechanisms driving placental insufficiency and subsequent ZIKV-mediated pathogenesis remain unclear. Here we show, using large scale metabolomics, that ZIKV infection reprograms placental lipidome by impairing the lipogenesis pathways. ZIKV-induced metabolic alterations provide building blocks for lipid droplet biogenesis and intracellular membrane rearrangements to support viral replication. Read More

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http://dx.doi.org/10.1038/s41467-020-16754-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7290035PMC

Maternal periconceptional and first trimester protein restriction in beef heifers: effects on maternal performance and early fetal growth.

Reprod Fertil Dev 2020 Jun;32(9):835-850

University of Adelaide, Robinson Research Institute, School of Medicine, North Terrace, Adelaide, SA 5005, Australia; and Corresponding author. Email:

This study evaluated the effect of protein restriction during the periconception (PERI) and first trimester (POST) periods on maternal performance, physiology and early fetal growth. Yearling nulliparous heifers (n=360) were individually fed a diet high or low in protein (HPeri and LPeri respectively) beginning 60 days before conception. From 24 to 98 days post-conception (dpc), half of each treatment group changed to the alternative post-conception high- or low-protein diet (HPost and LPost respectively), yielding four groups in a 2×2 factorial design with a common diet until parturition. Read More

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http://dx.doi.org/10.1071/RD19149DOI Listing

Predicting first-trimester outcome of embryos with cardiac activity in women with recurrent spontaneous abortion.

J Int Med Res 2020 Jun;48(6):300060520911829

The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen, Guangdong, China.

Objective: This study was performed to evaluate the capability of routine clinical indicators to predict the early outcome of embryos with cardiac activity in women with recurrent spontaneous abortion (RSA).

Methods: A retrospective cohort study of pregnant women with a history of RSA in a Chinese tertiary hospital was performed using unadjusted and multivariable logistic regression.

Results: Of 789 pregnant women with RSA, 625 (79. Read More

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http://dx.doi.org/10.1177/0300060520911829DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7294372PMC

Reduced frequency and functional defects of CD4CD25CD127 regulatory T cells in patients with unexplained recurrent spontaneous abortion.

Reprod Biol Endocrinol 2020 Jun 10;18(1):62. Epub 2020 Jun 10.

Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu, China.

Background: Unexplained recurrent spontaneous abortion (URSA) is defined as two or more consecutive pregnancy losses, generally of unknown cause; it is related to a failure of fetal-maternal immunological tolerance. Regulatory T cells (Tregs) exert immunosuppressive effects, which are essential to maintain fetal-maternal immunological tolerance and regulate immune balance. In this study, we used the specific cell-surface phenotype of CD4CD25CD127 Tregs to investigate the number and suppressive function of Tregs isolated from the peripheral blood of patients with URSA with the aim of expanding our understanding of their role in URSA. Read More

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http://dx.doi.org/10.1186/s12958-020-00619-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7285476PMC

Simple conization and pelvic lymphadenectomy in early-stage cervical cancer: A retrospective analysis and review of the literature.

Gynecol Oncol 2020 Jun 6. Epub 2020 Jun 6.

Department of Gynecologic Oncology, Fudan University Shanghai Cancer Centre, Shanghai, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China. Electronic address:

Objectives: To evaluate the feasibility of cervical conization and laparoscopic pelvic lymphadenectomy as a fertility-sparing surgery to treat early-stage cervical cancer.

Methods: We conducted a retrospective analysis from a prospectively maintained database of patients with stage IA1-IB1 grossly invisible cervical cancers undergoing conization plus laparoscopic lymphadenectomy between January 2014 and July 2019.

Results: Forty patients were identified. Read More

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http://dx.doi.org/10.1016/j.ygyno.2020.05.035DOI Listing

Risk of early neurodevelopmental outcomes associated with prenatal exposure to the antiepileptic drugs most commonly used during pregnancy: a French nationwide population-based cohort study.

BMJ Open 2020 Jun 7;10(6):e034829. Epub 2020 Jun 7.

Department of Epidemiology of Health Products, French National Agency for Medicines and Health Products Safety, Saint-Denis, France.

Objectives: To assess the association between prenatal exposure to monotherapy with the antiepileptic drugs (AEDs) most commonly used during pregnancy and the risk of various neurodevelopmental outcomes compared with lamotrigine.

Design: Nationwide population-based cohort study.

Setting: French national healthcare databases. Read More

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http://dx.doi.org/10.1136/bmjopen-2019-034829DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7282331PMC

Characteristics and outcomes of pregnant women admitted to hospital with confirmed SARS-CoV-2 infection in UK: national population based cohort study.

BMJ 2020 06 8;369:m2107. Epub 2020 Jun 8.

National Perinatal Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford OX3 7LF, UK.

Objectives: To describe a national cohort of pregnant women admitted to hospital with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in the UK, identify factors associated with infection, and describe outcomes, including transmission of infection, for mothers and infants.

Design: Prospective national population based cohort study using the UK Obstetric Surveillance System (UKOSS).

Setting: All 194 obstetric units in the UK. Read More

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http://dx.doi.org/10.1136/bmj.m2107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7277610PMC

Risk of surgical evacuation and risk of major surgery following second-trimester medical abortion in Denmark: a nationwide cohort study.

Contraception 2020 Jun 5. Epub 2020 Jun 5.

Department of Gynecology, Rigshospitalet, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 9, 2100 Copenhagen, Denmark.

Objective: The primary objectives were to 1) identify risk factors for surgical evacuation following medical termination of second-trimester pregnancies in Denmark and 2) assesses if these risk factors were able to explain the a priori observed variation in risk of surgical evacuation among Danish hospitals and the a priori observed decline in risk throughout time. The secondary objective was to estimate the risk of major surgery following second-trimester medical abortion. Study design We conducted a nationwide cohort study including all pregnancies terminated with mifepristone/misoprostol in second trimester in women aged 15-49 years through the period 2006-2017 in Denmark. Read More

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http://dx.doi.org/10.1016/j.contraception.2020.04.017DOI Listing

Synthetic PreImplantation Factor (sPIF) reduces inflammation and prevents preterm birth.

PLoS One 2020 8;15(6):e0232493. Epub 2020 Jun 8.

Università Cattolica del Sacro Cuore, Istituto di Clinica Ostetrica e Ginecologica, Roma, Italia.

Preterm birth (PTB) is the leading cause of neonatal morbidity and mortality and spontaneous PTB is a major contributor. The preceding inflammation/infection contributes not only to spontaneous PTB but is associated with neonatal morbidities including impaired brain development. Therefore, control of exaggerated immune response during pregnancy is an attractive strategy. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0232493PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7279576PMC

Diagnostic Potential of MicroRNAs as Biomarkers in the Detection of Preeclampsia.

Genet Test Mol Biomarkers 2020 Jun;24(6):321-327

Biomedical Center Martin JFM CU, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, Slovakia.

Preeclampsia is a multisystemic disorder that occurs in 5-8% of pregnant women and remains a leading cause of both maternal and fetal morbidity and mortality. The disease is characterized by the abnormal vascular response to placentation, but the exact pathophysiology and pathogenesis of preeclampsia remain unknown. Risk factors for preeclampsia include increased maternal age, obesity, multiple gestations, and a history of preeclampsia. Read More

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http://dx.doi.org/10.1089/gtmb.2019.0264DOI Listing

The polymorphism of rs11614913 T/T in pri- alters the miRNA expression and associates with recurrent spontaneous abortion in a Han-Chinese population.

Am J Transl Res 2020 15;12(5):1928-1941. Epub 2020 May 15.

Reproductive and Genetic Center of National Research Institute for Family Planning Beijing, China.

Rs11614913 in pri- is involved in the occurrence of many diseases, especially in cancers. However, it remains unknown whether is associated with human recurrent spontaneous abortion (RSA) in Chinese Han population. Our study found that rs11614913 T/T in pri- was associated with the increase risk of human unexplained RSA (URSA) in recessive mode in Chinese Han population. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7269987PMC