47,804 results match your criteria Early Pregnancy Loss

Communication after pregnancy and baby loss.

BJA Educ 2022 Jul 19;22(7):246-248. Epub 2022 Apr 19.

Bereavement Training International, Buckinghamshire, UK.

View Article and Full-Text PDF

The Alteration of mA Modification at the Transcriptome-Wide Level in Human Villi During Spontaneous Abortion in the First Trimester.

Front Genet 2022 8;13:861853. Epub 2022 Jun 8.

The First Affiliated Hospital of Shenzhen University, Reproductive Medicine Centre, Shenzhen Second People's Hospital, Shenzhen, China.

A growing number of studies have demonstrated that N6 methyladenine (mA) acts as an important role in the pathogenesis of reproductive diseases. Therefore, it is essential to profile the genome-wide mA modifications such as in spontaneous abortion. In this study, due to the trace of human villi during early pregnancy, we performed high-throughput sequencing in villous tissues from spontaneous abortion (SA group) and controls with induced abortion (normal group) in the first trimester. Read More

View Article and Full-Text PDF

Bacterial Vaginosis and Associated Factors Among Pregnant Women Attending Antenatal Care in Harar City, Eastern Ethiopia.

Infect Drug Resist 2022 16;15:3077-3086. Epub 2022 Jun 16.

Department of Medical Laboratory Science, College of Health and Medical Sciences, Haramaya University, Harar, Ethiopia.

Background: Bacterial vaginosis is one of the most common causes of abnormal vaginal discharge in women of reproductive age, especially pregnant women. It is characterized by the decrement of lactobacilli and increasing proliferation of diverse anaerobic bacteria. The prevalence of bacterial vaginosis and contributing factors vary between countries, within the same country, and among different populations. Read More

View Article and Full-Text PDF

Time-related Biases in Perinatal Pharmacoepidemiology: A Systematic Review of Observational Studies.

Pharmacoepidemiol Drug Saf 2022 Jun 26. Epub 2022 Jun 26.

Department of Epidemiology, Biostatistics, and Occupational Health, McGill University, Montreal, Quebec, Canada.

Background: Time-related biases, such as immortal time and time-window bias, frequently occur in pharmacoepidemiologic research. However, the prevalence of these biases in perinatal pharmacoepidemiology is not well understood.

Objective: To describe the frequency of time-related biases in observational studies of medications commonly used during pregnancy (antibiotic, antifungal, and antiemetic drugs) via systematic review. Read More

View Article and Full-Text PDF

Delayed versus early umbilical cord clamping for near-term infants born to preeclamptic mothers; a randomized controlled trial.

BMC Pregnancy Childbirth 2022 Jun 25;22(1):515. Epub 2022 Jun 25.

Obstetrics and Gynaecology Department, Faculty of Medicine, Cairo University, Cairo, Egypt.

Objective: This study aims to assess delayed versus early umbilical cord clamping in preeclamptic mothers undergoing scheduled caesarean delivery regarding the maternal intra-operative blood loss and neonatal outcomes.

Methods: A clinical trial was conducted on 62 near-term preeclamptic mothers (36-38 weeks) who were planned for caesarean delivery. They were randomly assigned into two groups. Read More

View Article and Full-Text PDF

Leaving the Placenta In Situ in Placenta Accreta Spectrum Disorders: A Single Center Case Series.

Am J Perinatol 2022 Jun 25. Epub 2022 Jun 25.

Obstetrics & Gynecology, University of Texas Health Sciences Center at Houston, Houston, United States.

The most common treatment for placenta accreta spectrum disorders (PAS) is planned primary cesarean-hysterectomy. However, other management strategies may improve outcomes and/or allow fertility preservation. This is a series of 11 patients with PAS managed by leaving the placenta in situ at a single academic center in the U. Read More

View Article and Full-Text PDF

Biological relevance of trophectoderm morphology: initial β-hCG measurements correlate with trophectoderm grading on euploid frozen embryo transfers.

J Assist Reprod Genet 2022 Jun 25. Epub 2022 Jun 25.

Reproductive Medicine Associates of New York, 635 Madison Ave, Floor 10th, New York City, NY, 10022, USA.

Objective: To analyze the correlation between TE grading and initial β-hCG serum level after single euploid embryo transfer. Secondarily, to explore the association between TE grading with subsequent IVF outcomes.

Design: Retrospective cohort analysis. Read More

View Article and Full-Text PDF

Downregulation of CDC42 inhibits the proliferation and stemness of human trophoblast stem cell via EZRIN/YAP inactivation.

Cell Tissue Res 2022 Jun 25. Epub 2022 Jun 25.

Department of Obstetrics and Gynecology, Guangdong Provincial Key Laboratory of Major Obstetric Diseases, The Third Affiliated Hospital of Guangzhou Medical University, Guangdong, Guangzhou, China.

Placental dysplasia increases the risk of recurrent spontaneous abortion (RSA). However, the underlying mechanism regulating placental development remains unclear. In this study, we showed that the expression of CDC42 was decreased in the villous tissue of RSA samples compared to healthy controls. Read More

View Article and Full-Text PDF

Pregnancy duration and ovarian cancer risk: a 50-year nationwide cohort study.

Int J Cancer 2022 Jun 24. Epub 2022 Jun 24.

Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.

A woman's reproductive history is strongly associated with her risk of ovarian cancer. However, it is unclear how pregnancies of different duration impact a woman's ovarian cancer risk, and therefore, what part of a pregnancy explains the protective effect. Using a cohort of all Danish women followed from 1968 to 2018, with prospectively registered information on reproductive history (eg, gestational duration of pregnancies, tubal ligation and resection, and hormonal pharmaceutical use), we investigated the effect of pregnancy duration on ovarian cancer risk. Read More

View Article and Full-Text PDF

Estimates of Stillbirths, Neonatal Mortality, and Medically Vulnerable Live Births in Amhara, Ethiopia.

JAMA Netw Open 2022 Jun 1;5(6):e2218534. Epub 2022 Jun 1.

Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.

Importance: Data on birth outcomes and early mortality are scarce, especially in settings with limited resources. Total births, both stillbirths and live births, are often not counted, yet such data are critical to allocate resources and target interventions to improve survival.

Objective: To estimate the prevalence of stillbirths, neonatal deaths, and medically vulnerable phenotypes, such as preterm births, small-for-gestational-age (SGA), large-for-gestational-age (LGA), and low-birth-weight (LBW) births, in a setting where these key indicators remain largely unknown. Read More

View Article and Full-Text PDF

Extracellular Vesicle-Associated MicroRNA-138-5p Regulates Embryo Implantation and Early Pregnancy by Adjusting GPR124.

Pharmaceutics 2022 May 30;14(6). Epub 2022 May 30.

Institute of Stem Cell and Translational Cancer Research, Chang Gung Memorial Hospital Linkou Medical Center, Chang Gung University School of Medicine, Taoyuan 333, Taiwan.

Functional embryo-maternal interactions occur during the embryo implantation and placentation. Extracellular vesicles with microRNA (miR) between cells have been considered of critical importance for embryo implantation and the programming of human pregnancy. MiR-138-5p functions as the transcriptional regulator of G protein-coupled receptor 124 (GPR124). Read More

View Article and Full-Text PDF

A Whole Genome Sequencing-Based Epidemiological Investigation of a Pregnancy-Related Invasive Listeriosis Case in Central Italy.

Pathogens 2022 Jun 8;11(6). Epub 2022 Jun 8.

Food Microbiology Unit, Istituto Zooprofilattico Sperimentale del Lazio e della Toscana "M. Aleandri", 00178 Rome, Italy.

Listeriosis is currently the fifth most common foodborne disease in Europe. Most cases are sporadic; however, outbreaks have also been reported. Compared to other foodborne infections, listeriosis has a modest incidence but can cause life-threatening complications, especially in elderly or immunocompromised people and pregnant women. Read More

View Article and Full-Text PDF

The Effect of Von Willebrand Disease on Pregnancy, Delivery, and Postpartum Period: A Retrospective Observational Study.

Medicina (Kaunas) 2022 Jun 7;58(6). Epub 2022 Jun 7.

Division of Gynaecology and Obstetrics, University Medical Centre, 1000 Ljubljana, Slovenia.

Several reports indicate that women with von Willebrand disease (VWD) are at an increased risk of bleeding and other complications during pregnancy and childbirth. The aim of this study was to investigate the effect of VWD on the course of pregnancy, childbirth, and the postpartum period. This was a retrospective study that compared many variables between women with VWD ( = 26) and women without VWD ( = 297,111) who gave birth between 2002 and 2016 in Slovenia. Read More

View Article and Full-Text PDF

Uterine Septum with or without Hysteroscopic Metroplasty: Impact on Fertility and Obstetrical Outcomes-A Systematic Review and Meta-Analysis of Observational Research.

J Clin Med 2022 Jun 8;11(12). Epub 2022 Jun 8.

Unit of Gynecology and Obstetrics, Department of Women and Children's Health, University of Padua, 35100 Padua, Italy.

Objective: we performed a systematic review/meta-analysis to evaluate the impact of septate uterus and hysteroscopic metroplasty on pregnancy rate-(PR), live birth rate-(LBR), spontaneous abortion-(SA) and preterm labor (PL) in infertile/recurrent miscarriage-(RM) patients.

Data Sources: a literature search of relevant papers was conducted using electronic bibliographic databases (Medline, Scopus, Embase, Science direct).

Study Eligibility Criteria: we included in this meta-analysis all types of observational studies that evaluated the clinical impact of the uterine septum and its resection (hysteroscopic metroplasty) on reproductive and obstetrics outcomes. Read More

View Article and Full-Text PDF

The Role of Kisspeptin in the Pathogenesis of Pregnancy Complications: A Narrative Review.

Int J Mol Sci 2022 Jun 14;23(12). Epub 2022 Jun 14.

Department of Obstetrics and Perinatology, Medical University of Lublin, Jaczewskiego 8, 20-090 Lublin, Poland.

Kisspeptins are the family of neuropeptide products of the gene that exert the biological action by binding with the G-protein coupled receptor 54 (GPR54), also known as the KISS-1 receptor. The kisspeptin level dramatically increases during pregnancy, and the placenta is supposed to be its primary source. The role of kisspeptin has already been widely studied in hypogonadotropic hypogonadism, fertility, puberty disorders, and insulin resistance-related conditions, including type 2 diabetes mellitus, polycystic ovary syndrome, and obesity. Read More

View Article and Full-Text PDF

H1299R Variant in Factor V and Recurrent Pregnancy Loss: A Systematic Review and Meta-Analysis Protocol.

Genes (Basel) 2022 Jun 6;13(6). Epub 2022 Jun 6.

Department of Chemical, Biological, Pharmaceutical, and Environmental Sciences, University of Messina, Viale Ferdinando Stagno D'Alcontres 31, 98166 Messina, Italy.

Recurrent pregnancy loss (RPL) is defined as the loss of two or more pregnancies, affecting approximately 1 to 3% of women worldwide. Scientific data highlight a possible correlation between thrombophilic genetic variants and RPL. H1299R variant in the factor V gene would lead to an increased thrombotic risk associated with frequent miscarriages. Read More

View Article and Full-Text PDF

Association Study between Mucin 4 () Polymorphisms and Idiopathic Recurrent Pregnancy Loss in a Korean Population.

Genes (Basel) 2022 May 24;13(6). Epub 2022 May 24.

Department of Biomedical Science, College of Life Science, CHA University, Seongnam 13488, Korea.

Recurrent pregnancy loss (RPL) is the loss of two or more consecutive pregnancies before 20 weeks of gestational age. Our study investigated whether mucin 4 () polymorphisms are associated with RPL. polymorphisms (rs882605 C>A, rs1104760 A>G, rs2688513 A>G, rs2258447 C>T, and rs2291652 A>G) were genotyped in 374 women with RPL and 239 controls of Korean ethnicity using polymerase chain reaction-restriction fragment length polymorphism analysis and the TaqMan probe SNP genotyping assay. Read More

View Article and Full-Text PDF

Stem Cell-Based Trophoblast Models to Unravel the Genetic Causes of Human Miscarriages.

Cells 2022 Jun 14;11(12). Epub 2022 Jun 14.

Research Institute of Medical Genetics, Tomsk National Research Medical Center, 634050 Tomsk, Russia.

Miscarriage affects approximately 15% of clinically recognized pregnancies, and 1-3% of couples experience pregnancy loss recurrently. Approximately 50-60% of miscarriages result from chromosomal abnormalities, whereas up to 60% of euploid recurrent abortions harbor variants in candidate genes. The growing number of detected genetic variants requires an investigation into their role in adverse pregnancy outcomes. Read More

View Article and Full-Text PDF

Water carrying in hills of Nepal-associations with women's musculoskeletal disorders, uterine prolapse, and spontaneous abortions.

PLoS One 2022 23;17(6):e0269926. Epub 2022 Jun 23.

Department of Sanitation, Swiss Federal Institute of Aquatic Science and Technology (Eawag), Water and Solid Waste for Development (Sandec), Dübendorf, Switzerland.

More than a third of women in Nepal have to carry water from source to home to satisfy their families' daily needs. A cross-sectional study was carried out in a hilly area in Nepal to assess water-carrying practices and their association with women's health. Quantitative interviews were conducted with 1001 women of reproductive age and were complemented with health surveys carried out by health professionals and structured observations of water carrying. Read More

View Article and Full-Text PDF

Gene editing provides a tool to investigate genes involved in reproduction of pigs.

Mol Reprod Dev 2022 Jun 23. Epub 2022 Jun 23.

Division of Animal Sciences, University of Missouri, Columbia, Missouri, USA.

CRISPR-Cas9 gene editing technology provides a method to generate loss-of-function studies to investigate, in vivo, the specific role of specific genes in regulation of reproduction. With proper design and selection of guide RNAs (gRNA) designed to specifically target genes, CRISPR-Cas9 gene editing allows investigation of factors proposed to regulate biological pathways involved with establishment and maintenance of pregnancy. The advantages and disadvantages of using the current gene editing technology in a large farm species is discussed. Read More

View Article and Full-Text PDF

Adverse Effects of Polycystic Ovarian Syndrome on Pregnancy Outcomes in Women With Frozen-Thawed Embryo Transfer: Propensity Score-Matched Study.

Front Endocrinol (Lausanne) 2022 6;13:878853. Epub 2022 Jun 6.

Department of Traditional Chinese Medicine Gynecology, Changhai Hospital, Shanghai, China.

Purpose: This work aimed to evaluate the adverse effect of polycystic ovary syndrome (PCOS) on pregnancy outcomes of singletons after vitrification in women with frozen-thawed embryo transfer (FET).

Methods: Patients with/without PCOS who underwent FET from January 2013 and December 2018 were included. Propensity score matching (PSM) was used to reduce the influence of bias. Read More

View Article and Full-Text PDF

[Villi exosomes deliver HLA-G to enhance the expression of osteoglycin and pleiotrophin in decidual NK cells].

Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2022 Jun;38(6):535-541

Reproductive Medicine Center, Department of Obstetrics and Gynecology, Tangdu Hospital, Air Force Medical University, Xi'an 710038, China. *Corresponding author, E-mail:

Objective To identify the effect of HLA-G-containing exosomes on the secretory function of growth-promoting factors osteoglycin (OGN) and pleiotrophin (PTN) by decidual NK (dNK) cells. Methods dNK cells were co-cultured with HLA-G-containing exosomes from the villi of patients undergoing unexplained recurrent pregnancy loss (uRPL) and normal induced abortion, respectively. Sequentially, OGN and PTN of the dNK cells were determined using real time quantitative PCR and western blotting. Read More

View Article and Full-Text PDF

Infertility, recurrent pregnancy loss, and risk of stroke: pooled analysis of individual patient data of 618 851 women.

BMJ 2022 06 22;377:e070603. Epub 2022 Jun 22.

University of Queensland, School of Public Health, Queensland, Australia

Objective: To examine the associations of infertility, recurrent miscarriage, and stillbirth with the risk of first non-fatal and fatal stroke, further stratified by stroke subtypes.

Design: Individual participant pooled analysis of eight prospective cohort studies.

Setting: Cohort studies across seven countries (Australia, China, Japan, Netherlands, Sweden, the United Kingdom, and the United States) participating in the InterLACE (International Collaboration for a Life Course Approach to Reproductive Health and Chronic Disease Events) consortium, which was established in June 2012. Read More

View Article and Full-Text PDF

Circ-CCNB1 modulates trophoblast proliferation and invasion in spontaneous abortion by regulating miR-223/SIAH1 axis.

Endocrinology 2022 Jun 22. Epub 2022 Jun 22.

Department of Reproductive Endocrinology, Women's Hospital, Zhejiang University School of Medicine, Hangzhou, 310006, PR China.

Purpose: Spontaneous abortion (SA) is a common disorder in early pregnancy. Circular RNAs (circRNAs) have been reported to exert important regulatory effects on trophoblast function and embryo development. The aim of this study was to explore whether and how circRNAs regulate trophoblast function in SA during early pregnancy. Read More

View Article and Full-Text PDF

Mycobiome Dysbiosis in Women with Intrauterine Adhesions.

Microbiol Spectr 2022 Jun 22:e0132422. Epub 2022 Jun 22.

State Key Laboratory of Oncogenes and Related Genes, Center for Single-Cell Omics, School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

The vaginal microbiota dysbiosis is closely associated with the development of reproductive diseases. However, the contribution of mycobiome to intrauterine adhesion (IUA) disease remains unknown. Harnessing 16S and ITS2 rDNA sequencing analysis, we investigate both bacterial and fungal microbiota compositions across 174 samples taken from both cervical canal (CC) and middle vagina (MV) sites of IUA patients. Read More

View Article and Full-Text PDF

Successful pregnancy with restorative reproductive medicine after 16 years of infertility, three recurrent miscarriages, and eight unsuccessful embryo transfers with in vitro fertilization/intracytoplasmic sperm injection: a case report.

J Med Case Rep 2022 Jun 22;16(1):246. Epub 2022 Jun 22.

NeoFertility, Zagreb, Croatia.

Background: Restorative reproductive medicine represents a comprehensive approach to subfertility (infertility and miscarriage) with investigations, diagnoses, and treatments combined with fertility charting to restore optimal reproductive function. Restorative reproductive medicine assumes that multiple factors need to be identified and treated (cycle optimization) for up to 12 cycles to achieve a successful pregnancy. Conception can occur during normal intercourse without intrauterine insemination or in vitro fertilization. Read More

View Article and Full-Text PDF

Views of health professionals on the impact of early miscarriage on women's mental health and the accessibility of services and support.

N Z Med J 2022 Jan 21;135(1548):54-64. Epub 2022 Jan 21.

Department of Obstetrics, Gynaecology and Women's Health and Department of Pathology and Molecular Medicine, University of Otago Wellington, Wellington, Aotearoa New Zealand.

Aim: To explore health professionals' views on the impact of early miscarriage on mental health and accessibility of services and support available to women.

Methods: Semi-structured interviews were conducted with 10 health professionals from an urban tertiary hospital and a community setting, followed by semi-inductive thematic analysis.

Results: Three overarching themes were identified: (1) extent and nature of psychological impact, (2) barriers to accessing mental health support and (3) facilitators of change or improvement. Read More

View Article and Full-Text PDF
January 2022

The effect of hysteroscopic metroplasty on fertility in T-shaped and Y-shaped dysmorphic uterus.

Eur J Contracept Reprod Health Care 2022 Jun 21:1-6. Epub 2022 Jun 21.

Department of Reproductive Endocrinology and IVF, University of Health Sciences, Etlik Zubeyde Hanim Women's Health, Training and Research Hospital, Ankara, Turkey.

Objective: T/Y-shaped dysmorphic uterus is frequently associated with subfertility, abortion, preterm delivery, and recurrent implantation failure. In this study, the impact of hysteroscopic metroplasty for a T/Y-shaped uterus on obstetric outcomes was investigated in patients with infertility and recurrent pregnancy loss (RPL) and compared the uterine anomaly subgroups.

Method: Cases with infertility and/or RPL diagnosed with T/Y-shaped uterus by hysterosalpingography (HSG) and 3D transvaginal ultrasonography (3D TVUSG) with no other male or female pathology have recruited the study. Read More

View Article and Full-Text PDF

Preconception reproductive tract infections status and adverse pregnancy outcomes: a population-based retrospective cohort study.

BMC Pregnancy Childbirth 2022 Jun 20;22(1):501. Epub 2022 Jun 20.

NHC Key Lab. of Reproduction Regulation, Shanghai Institute for Biomedical and Pharmaceutical Technologies, Fudan University, 400020, Shanghai, China.

Background: Reproductive tract infections can cause serious adverse outcomes for pregnant women such as spontaneous abortion and preterm birth. However, it is unclear whether maternal reproductive tract infection before pregnancy would also be related to any adverse pregnancy outcomes. This study aims to investigate the association of maternal preconception reproductive tract infections with subsequent adverse pregnancy outcomes. Read More

View Article and Full-Text PDF