42,266 results match your criteria Early Pregnancy Loss


Syphilis in Pregnancy: The Reality in a Public Hospital.

Rev Bras Ginecol Obstet 2019 Feb 20;41(2):90-96. Epub 2019 Feb 20.

Department of Fetal Medicine, Universidade Federal do Triângulo Mineiro, Uberaba, MG, Brazil.

Objective:  The present study assessed epidemiological and obstetrical data from pregnant women with syphilis at the Hospital de Clínicas of the Universidade Federal do Triângulo Mineiro (UFTM, in the Portuguese acronym), describing this disease during pregnancy and its vertical transmission for future healthcare actions.

Methods:  Records from pregnant women who had been admitted to the Obstetrics Department of the Hospital de Clínicas of the UFTM and were diagnosed with syphilis between 2007 and 2016 were reviewed. A standardized form was used to collect epidemiological, obstetric data and outcomes of congenital infection. Read More

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http://dx.doi.org/10.1055/s-0038-1676569DOI Listing
February 2019

Association between hereditary predisposition to common cancers and congenital multimalformations.

Congenit Anom (Kyoto) 2019 Feb 20. Epub 2019 Feb 20.

Centre Jean Perrin (Comprehensive Cancer Center), Clermont-Ferrand, France.

Introduction: in a previous article we reported that mutations favoring cancer at adulthood seemed to improve fertility and limit miscarriages. Because spontaneous abortion may result from anomalies in embryo, we questioned if an increased frequency of congenital malformation could be evidenced among cancer prone families.

Methods: oncogenetics database (≈193,000 members) of the comprehensive cancer center Jean Perrin was crossed with regional registry of congenital malformations (≈10,000). Read More

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http://dx.doi.org/10.1111/cga.12329DOI Listing
February 2019

Influence of forkhead box protein 3 polymorphisms (rs2232365, rs3761548) with the outcome of pregnancy: A meta-analysis.

J Cell Physiol 2019 Feb 19. Epub 2019 Feb 19.

Department of Immunology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.

Dysfunction of regulatory T cells (Tregs) may contribute to certain immune-related pregnancy complications. Forkhead box protein 3 (FOXP3) is the key transcription factor of Treg. We performed a systematic review and meta-analysis to evaluate the possible association between FOXP3 polymorphisms -924A/G (rs2232365) and -3279C/A (rs3761548) and immune-related pregnancy complications. Read More

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http://dx.doi.org/10.1002/jcp.28328DOI Listing
February 2019

Associations between low- and high-dose oral fluconazole and pregnancy outcomes: 3 nested case-control studies.

CMAJ 2019 Feb;191(7):E179-E187

Research Centre (Bérard, Sheehy, Zhao, Gorgui), CHU Sainte-Justine; Faculty of Pharmacy (Bérard, Gorgui), University of Montreal; Faculty of Medicine (Bernatsky, Moura), McGill University; Faculty of Medicine, Department of Clinical Epidemiology (Abrahamowicz), McGill University, Montréal, Que.

Background: While topical azoles are the first-line treatment for fungal infections, oral fluconazole is frequently used during pregnancy. We aimed to assess the effect of exposure to low and high doses of fluconazole during pregnancy on the occurrence of spontaneous abortions, major congenital malformations and stillbirths.

Methods: Within the Quebec Pregnancy Cohort (1998-2015), we identified women exposed to low- (≤ 150 mg) and high-dose (> 150 mg) fluconazole, and women who were not exposed. Read More

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http://dx.doi.org/10.1503/cmaj.180963DOI Listing
February 2019

The role of maternal homocysteine concentration in placenta-mediated complications: findings from the Ottawa and Kingston birth cohort.

BMC Pregnancy Childbirth 2019 Feb 19;19(1):75. Epub 2019 Feb 19.

The Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.

Background: Homocysteine is an intermediate metabolite implicated in the risk of placenta-mediated complications, including preeclampsia, placental abruption, fetal growth restriction, and pregnancy loss. Large cohort and case-control studies have reported inconsistent associations between homocysteine and these complications. The purpose of this study was to investigate whether elevated maternal plasma homocysteine concentration in the early to mid-second trimester is associated with an increased risk of placenta-mediated complications. Read More

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http://dx.doi.org/10.1186/s12884-019-2219-5DOI Listing
February 2019

H19 regulates trophoblastic spheroid adhesion by competitively binding to let-7.

Reproduction 2019 Feb 1. Epub 2019 Feb 1.

N Liu, reproductive center of medicine, Xiangya Hospital Central South University, Changsha, China.

Integrin β3 (ITGB3), which is the target gene of the miRNA let-7 that can be antagonized by long noncoding RNA (lncRNA) H19, is well-known to have a critical role in endometrium receptivity. However, the regulation of ITGB3 in cell-cell or cell-extracellular matrix adhesion and invasion for the maintenance of early pregnancy remains unknown. This study aimed to explore the role of the H19/let-7/ITGB3 axis in regulating trophoblastic spheroid adhesion and in vitro invasion ability using the HTR-8/SVneo cell line and to investigate the expression levels of lncRNA H19 and ITGB3 in human products of conception. Read More

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http://dx.doi.org/10.1530/REP-18-0339DOI Listing
February 2019

Cell-cell contact with proinflammatory macrophages enhances the immunotherapeutic effect of mesenchymal stem cells in two abortion models.

Cell Mol Immunol 2019 Feb 18. Epub 2019 Feb 18.

Laboratory for Reproductive Immunology, NHC Key Lab of Reproduction Regulation (Shanghai Institute of Planned Parenthood Research), Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Hospital of Obstetrics and Gynecology, Fudan University Shanghai Medical College, Shanghai, China.

Mesenchymal stem cells (MSCs), which are pluripotent cells with immunomodulatory properties, have been considered good candidates for the therapy of several immune disorders, such as inflammatory bowel diseases, concanavalin A-induced liver injury, and graft-versus-host disease. The embryo is a natural allograft to the maternal immune system. A successful pregnancy depends on the timely extinction of the inflammatory response induced by embryo implantation, followed by the switch to a tolerant immune microenvironment in both the uterus and the system. Read More

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http://dx.doi.org/10.1038/s41423-019-0204-6DOI Listing
February 2019

Social work intervention for women experiencing early pregnancy loss in the emergency department.

Soc Work Health Care 2019 Feb 18:1-20. Epub 2019 Feb 18.

a School of Social Work , Lakehead University , Thunder Bay , ON , Canada.

Often referred to as miscarriage, Early Pregnancy Loss (EPL) is the spontaneous death of a fetus experienced within the first 20 weeks of gestation and is the most common complication in pregnancy. Symptoms of an impending EPL are routinely managed in the Emergency Department (ED). EPL can have a substantial impact on women, potentially leading to psychological and emotional health issues and risks to future pregnancies. Read More

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http://dx.doi.org/10.1080/00981389.2019.1580237DOI Listing
February 2019

Recombinant human granulocyte- colony stimulating factor in women with unexplained recurrent pregnancy losses: a randomized clinical trial.

Hum Reprod 2019 Feb 18. Epub 2019 Feb 18.

Nora Therapeutics, Inc., 530 Lytton Avenue, 2nd Floor, Palo Alto, CA, USA.

Study Question: Does administration of recombinant human granulocyte colony stimulating factor (rhG-CSF) in the first trimester improve pregnancy outcomes, among women with a history of unexplained recurrent pregnancy loss?

Summary Answer: rhG-CSF administered in the first trimester of pregnancy did not improve outcomes among women with a history of unexplained recurrent pregnancy loss.

What Is Known Already: The only previous randomized controlled study of granulocyte colony stimulating factor in recurrent miscarriage in 68 women with unexplained primary recurrent miscarriage found a statistically significant reduction in miscarriage and improvement in live birth rates. A further four observational studies where G-CSF was used in a recurrent miscarriage population were identified in the literature, two of which confirmed statistically significant increase in clinical pregnancy and live birth rates. Read More

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http://dx.doi.org/10.1093/humrep/dey393DOI Listing
February 2019

Trophoblastic proliferation and invasion regulated by ACTN4 is impaired in early onset preeclampsia.

FASEB J 2019 Feb 18:fj201802058RR. Epub 2019 Feb 18.

State Key Laboratory of Maternal and Fetal Medicine of Chongqing Municipality, Chongqing Medical University, Chongqing, China.

Successful pregnancy requires normal placentation, which largely depends on the tight regulation of proliferation, invasion, and migration of trophoblast cells. Abnormal functioning of trophoblast cells may cause failure of uterine spiral artery remodeling, which may be related to pregnancy-related disorders, such as preeclampsia. Here, we reported that an actin-binding protein, α-actinin (ACTN)4, was dysregulated in placentas from early onset preeclampsia. Read More

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http://dx.doi.org/10.1096/fj.201802058RRDOI Listing
February 2019

Late stillbirth due to listeriosis.

Autops Case Rep 2018 Oct-Dec;8(4):e2018051. Epub 2018 Oct 22.

Hospital Universitário Puerta del Mar, Department of Pediatrics, Division of Neonatology. Cádiz, Spain.

Listeriosis is a sporadic infectious disease, which affects high-risk populations, such as the elderly, pregnant women, newborns, and immunocompromised patients. During pregnancy, listeriosis usually presents like a mild non-specific infection, but it may be responsible for fetal loss, preterm labor, early onset neonatal sepsis, and neonatal death. We report the case of a late stillbirth secondary to maternal chorioamnionitis. Read More

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http://dx.doi.org/10.4322/acr.2018.051DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360831PMC
October 2018
1 Read

[In vitro fertilization-embryo transfer affects focal adhension kinase signaling pathway in early placenta].

Beijing Da Xue Xue Bao Yi Xue Ban 2019 Feb;51(1):151-158

Department of Obstetrics and Gynecology, Beijing Jishuitan Hospital, Beijing 100035, China.

Objective: To study the effects of in vitro fertilization-embryo transfer (IVF-ET) technique on gene expression of focal adhension kinase (FAK) signaling pathway in early placental trophoblast cells, and to explore the effects of IVF-ET technology on the development and function of early placenta.

Methods: We collected 7-8 weeks of gestation placenta tissue as a study group by ultrasound guided reduction of fetal from double embryo transfer under IVF-ET technology. In the control group, placenta tissues were obtained from the spontaneous abortion of natural pregnancy twin 7-8 weeks. Read More

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http://dx.doi.org/10.19723/j.issn.1671-167X.2019.01.026DOI Listing
February 2019

Management of idiopathic recurrent pericarditis during pregnancy.

Int J Cardiol 2019 Feb 6. Epub 2019 Feb 6.

University Cardiology AOU, Città della Salute e della Scienza di Torino, Torino, Italy.

Background: Data concerning idiopathic recurrent pericarditis in pregnancy are scarce.

Objectives: To evaluate the management and outcome of idiopathic recurrent pericarditis during pregnancy.

Methods And Results: Twenty-one pregnancies were evaluated in fourteen women with a history of recurrent idiopathic pericarditis (mean maternal age 31. Read More

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http://dx.doi.org/10.1016/j.ijcard.2019.02.003DOI Listing
February 2019

Risk factors for surgical intervention of early medical abortion.

Am J Obstet Gynecol 2019 Feb 11. Epub 2019 Feb 11.

Department of Gynaecology, Rigshospitalet, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 9, 2100 Copenhagen, Denmark.

Background: By being non-invasive, medical termination of pregnancy has increased worldwide access to abortion and improved safety of unsafe abortion. However, secondary surgical intervention is the most frequent complication to medical abortion.

Objective: We aimed to identify and quantify risk factors for surgical intervention in women undergoing medically induced termination of pregnancy before nine completed weeks of gestation. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00029378193035
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http://dx.doi.org/10.1016/j.ajog.2019.02.014DOI Listing
February 2019
2 Reads

Active versus expectant management for women in the third stage of labour.

Cochrane Database Syst Rev 2019 Feb 13;2:CD007412. Epub 2019 Feb 13.

School of Nursing and Midwifery, Trinity College Dublin, 24 D'Olier Street, Dublin, Ireland.

Background: Active management of the third stage of labour involves giving a prophylactic uterotonic, early cord clamping and controlled cord traction to deliver the placenta. With expectant management, signs of placental separation are awaited and the placenta is delivered spontaneously. Active management was introduced to try to reduce haemorrhage, a major contributor to maternal mortality in low-income countries. Read More

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http://dx.doi.org/10.1002/14651858.CD007412.pub5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372362PMC
February 2019
2 Reads

"It Can't Be Like Last Time" - Choices Made in Early Pregnancy by Women Who Have Previously Experienced a Traumatic Birth.

Front Psychol 2019 25;10:56. Epub 2019 Jan 25.

Faculty of Health Sciences, University of Hull, Hull, United Kingdom.

A significant number of women experience childbirth as traumatic. These experiences are often characterized by a loss of control coupled with a perceived lack of support and inadequate communication with health care providers. Little is known about the choices women make in subsequent pregnancy(s) and birth(s), or why they make these choices. Read More

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http://dx.doi.org/10.3389/fpsyg.2019.00056DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355667PMC
January 2019
1 Read

Management of early pregnancy loss, with a focus on patient centered care.

Semin Perinatol 2018 Dec 20. Epub 2018 Dec 20.

Department of Obstetrics and Gynecology, University of Pennsylvania, 3400 Spruce Street, 1000 Courtyard, Philadelphia, PA 19104, USA.

Early pregnancy loss is the most common complication in pregnancy. Management options for miscarriage include expectant management, medical intervention, or surgical aspiration. Non-surgical and surgical management are all safe and acceptable options for medically uncomplicated patients. Read More

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http://dx.doi.org/10.1053/j.semperi.2018.12.005DOI Listing
December 2018
1 Read

Pregnancy intervals after stillbirth, neonatal death and spontaneous abortion and the risk of an adverse outcome in the next pregnancy in rural Bangladesh.

BMC Pregnancy Childbirth 2019 Feb 9;19(1):62. Epub 2019 Feb 9.

Department of International Health and International Center for Maternal and Newborn Health, Johns Hopkins Bloomberg School of Public Health, 615 N. Wolfe Street, Baltimore, MD, 21205, USA.

Background: Studies have revealed associations between preceding short and long birth-to-birth or birth-to-pregnancy intervals and poor pregnancy outcomes. Most of these studies, however, have examined the effect of intervals that began with live births. Using data from Bangladesh, we examined the effect of inter-outcome intervals (IOI) starting with a non-live birth or neonatal death, on outcomes in the next pregnancy. Read More

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http://dx.doi.org/10.1186/s12884-019-2203-0DOI Listing
February 2019
2 Reads

Myeloid Derived Suppressor Cells Depletion May Cause Pregnancy Loss via Upregulating the Cytotoxicity of Decidual Natural Killer Cells.

Am J Reprod Immunol 2019 Feb 9:e13099. Epub 2019 Feb 9.

International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

Problem: Maternal immune system tolerance to the semiallogeneic fetus is critical for a successful pregnancy. Studies have shown that myeloid-derived suppressor cells (MDSCs) play an important role in maintaining feto-maternal tolerance. However, the mechanisms remain poorly understood. Read More

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http://doi.wiley.com/10.1111/aji.13099
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http://dx.doi.org/10.1111/aji.13099DOI Listing
February 2019
3 Reads

Decidual RANKL/RANK interaction promotes the residence and polarization of TGF-β1-producing regulatory γδ T cells.

Cell Death Dis 2019 Feb 8;10(2):113. Epub 2019 Feb 8.

Key Laboratory of Reproduction Regulation of NPFPC, SIPPR, IRD, Hospital of Obstetrics and Gynecology, Fudan University Shanghai Medical College, 200011, Shanghai, People's Republic of China.

Abstact: Decidual γδΤ (dγδΤ) cells play an essential role during successful pregnancy; however, the residence and polarization of γδΤ cells in decidua remain unclear. In this study, we observed higher levels of receptor activator for nuclear factor-κ B ligand (RANKL) on decidual stromal cells (DSCs), and its receptor RANK on dγδΤ cells in decidua from normal pregnancy compared with patients with recurrent spontaneous abortion (RSA). RANKL expressed by DSCs can induce the polarization of peripheral blood γδΤ (pγδΤ) and dγδΤ cells to Foxp3 + γδΤ cells, and upregulate the expression of transforming growth factor (TGF)-β1. Read More

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http://dx.doi.org/10.1038/s41419-019-1380-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368618PMC
February 2019
1 Read

MicroRNA-145 targets Smad1 in endometrial stromal cells and regulates decidualization in rat.

J Mol Med (Berl) 2019 Feb 7. Epub 2019 Feb 7.

Division of Endocrinology, CSIR-Central Drug Research Institute|, Lucknow, Uttar Pradesh, 226031, India.

Decidualization of endometrial stromal cells is the pre-requisite for the embryo implantation and establishment of pregnancy. Although known to be regulated by several factors, the process of regulation of decidualization by miRNAs is largely unknown. Previous reports suggest that the upregulated expression of miR-145 is associated with repeated implantation failure. Read More

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http://dx.doi.org/10.1007/s00109-019-01744-6DOI Listing
February 2019
2 Reads

Hyperreactio luteinalis and hypothyroidism: A case report.

Case Rep Womens Health 2019 Jan 29;21:e00094. Epub 2018 Dec 29.

Research Committee, "Dr. Alberto Romo Caballero" School of Medicine, Universidad Autónoma de Tamaulipas, Tampico, Tamaulipas, Mexico.

We report a case of hyperreactio luteinalis (HL) and hypothyroidism diagnosed at 13 weeks of pregnancy. A 29-year-old woman with a spontaneous 13-week singleton pregnancy presented with hirsutism and a pelvic mass. Ultrasound showed a viable pregnancy compatible with the gestational age and multiple cystic lesions on both ovaries. Read More

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http://dx.doi.org/10.1016/j.crwh.2018.e00094DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350097PMC
January 2019
1 Read

Outcomes of Pregnancy in Women With Inflammatory Myositis: A Retrospective Cohort From India.

J Clin Rheumatol 2019 Feb 1. Epub 2019 Feb 1.

From the Department of Clinical Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India.

Objectives: Idiopathic inflammatory myositis (IIM) commonly affects women in the childbearing age group. Both disease activity and immunosuppressants used may have adverse effects on fertility and outcomes of pregnancy. We explored these outcomes in a retrospective cohort of women with IIM. Read More

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http://dx.doi.org/10.1097/RHU.0000000000000996DOI Listing
February 2019
3 Reads

Transabdominal cerclage for cervical insufficiency in twins: series of seven cases and literature review.

J Matern Fetal Neonatal Med 2019 Feb 5:1-11. Epub 2019 Feb 5.

a Obstetrics Department , Cliniques Universitaires Saint Luc , Brussels , Belgium.

Background: The diagnosis of cervical insufficiency is based on previous history of recurrent second or early third trimester losses. Its incidence among pregnant women is 0,5-1%, but can be as high as 75% among women with preterm birth. Transvaginal cerclage (TVC) is the common therapy of cervical insufficiency. Read More

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http://dx.doi.org/10.1080/14767058.2019.1579192DOI Listing
February 2019
2 Reads

Upregulation of ADAMTS‑7 and downregulation of COMP are associated with spontaneous abortion.

Mol Med Rep 2019 Jan 28. Epub 2019 Jan 28.

Reproductive Medicine Center, Renmin Hospital of Wuhan University, Hubei Clinic Research Center for Assisted Reproductive Technology and Embryonic Development, Wuhan University, Wuhan, Hubei 430060, P.R. China.

A disintegrin and metalloproteinase with thrombospondin motifs 7 (ADAMTS‑7) has been revealed to serve an important role in inflammation‑associated diseases. However, the role of ADAMTS‑7 in spontaneous abortion (SA) remains unclear. In the present study, human and mouse decidual tissues were used to detect the expression of ADAMTS‑7 and cartilage oligomeric matrix protein (COMP) in mice with lipopolysaccharide (LPS)‑induced abortion (10 mice/group), and in SA humans and the corresponding control group (21 participants in the SA group and 15 participants in the control group). Read More

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http://dx.doi.org/10.3892/mmr.2019.9898DOI Listing
January 2019
1 Read

Tensions and Contradictions in Interns' Communication about Unexpected Pregnancy Loss.

Health Commun 2019 Feb 5:1-9. Epub 2019 Feb 5.

a Department of Communication Studies , Indiana University-Purdue University Indianapolis.

Early miscarriage is an unexpected pregnancy complication that affects up to 25% of pregnant women. Physicians are often tasked with delivering the bad news of a pregnancy loss to asymptomatic women while also helping them make an informed decision about managing the miscarriage. Assessing the communicative responses, particularly the discursive tensions embedded within providers' speech, offers insight into the (in)effective communication used in the delivery of bad news and the management of a potentially traumatic medical event. Read More

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http://dx.doi.org/10.1080/10410236.2019.1570429DOI Listing
February 2019
1 Read

Prognostic value of repeated serum kisspeptin measurements in early first trimester pregnancy: a preliminary study.

Reprod Biomed Online 2018 Dec 7. Epub 2018 Dec 7.

Department of Obstetrics and Gynecology, Qilu Hospital of Shandong University, 107 Wenhua Xi Road, Jinan Shandong 250012, People's Republic of China. Electronic address:

Research Question: What is the diagnostic value of maternal kisspeptin in patients with asymptomatic first-trimester pregnancies, and what is the prognostic significance of kisspeptin versus beta-HCG in early pregnancies.

Design: Case-control study in academic medical centres. Patients with no confounding co-morbidities who conceived by IVF and intracytoplasmic sperm injection were analysed. Read More

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http://dx.doi.org/10.1016/j.rbmo.2018.11.014DOI Listing
December 2018

High Prevalence of Maternal Serum 25-Hydroxyvitamin D Deficiency Is Not Associated With Poor Birth Outcomes Among Healthy White Women in the Pacific Northwest.

J Obstet Gynecol Neonatal Nurs 2019 Feb 1. Epub 2019 Feb 1.

Objective: To quantify vitamin D status among pregnant women in the Pacific Northwest (Portland, OR, and Seattle, WA) and examine pregnancy and newborn outcomes in relationship to maternal serum blood samples obtained during pregnancy.

Design: A retrospective cohort design.

Setting: Data from 2009 to 2013 were abstracted from the health records of two out-of-hospital midwifery practices in the Pacific Northwest. Read More

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http://dx.doi.org/10.1016/j.jogn.2019.01.001DOI Listing
February 2019
2 Reads

Reproductive outcomes after surgical treatment of asherman syndrome: A systematic review.

Best Pract Res Clin Obstet Gynaecol 2019 Jan 3. Epub 2019 Jan 3.

Assisted Reproductive Technology Unit, Department of Obstetrics and Gynaecology, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong. Electronic address:

In this systematic review, we analysed the reproductive outcomes of hysteroscopic adhesiolysis in women with Asherman syndrome (AS). We searched PubMed, Web of Science and Cochrane Library (from database inception to April 2018) and selected studies that quantitatively described the reproductive outcomes. We assessed study quality and pooled rate data for each outcome. Read More

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http://dx.doi.org/10.1016/j.bpobgyn.2018.12.009DOI Listing
January 2019

Symposium review: Immunological detection of the bovine conceptus during early pregnancy.

Authors:
Troy L Ott

J Dairy Sci 2019 Jan 31. Epub 2019 Jan 31.

Department of Animal Science, Center for Reproductive Biology and Health, Huck Institutes of the Life Science, Pennsylvania State University, University Park 16802. Electronic address:

Infertility and subfertility reduce the economic viability of dairy production. Inflammation reduces conception rates in dairy cattle, but surprisingly little information exists about the populations and the functions of immune cells at the conceptus-maternal interface during the periattachment period in dairy cattle. Early pregnancy is accompanied by immune stimulation at insemination and conceptus secretion of IFN-τ, pregnancy-associated glycoproteins, prostaglandins, and other molecules whose effects on immune function during early pregnancy have not been determined. Read More

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http://dx.doi.org/10.3168/jds.2018-15668DOI Listing
January 2019
2 Reads

Evidence of reduced vertical transmission of Neospora caninum associated with higher IgG1 than IgG2 serum levels and presence of IFN-γ in non-aborting chronically infected cattle under natural condition.

Vet Immunol Immunopathol 2019 Feb 8;208:53-57. Epub 2019 Jan 8.

Consejo Nacional de Investigaciones Científicas y Tecnológicas, CONICET, Argentina; Instituto de Virología. Centro de Investigaciones en Ciencias Veterinarias y Agronómicas, Instituto Nacional de Tecnología Agropecuaria (INTA), Buenos Aires, Argentina. Electronic address:

Neospora caninum infection of cattle can be vertically transmitted, resulting in abortion or birth of infected calves. Vertical transmission occurs both in acutely or chronically infected cattle. There is little information on the immune response needed to prevent endogenous transplacental transmission, particularly from chronically infected cattle to their offspring in a natural environment. Read More

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http://dx.doi.org/10.1016/j.vetimm.2019.01.001DOI Listing
February 2019
2 Reads

Comparative transcriptome analysis of embryo invasion in the mink uterus.

Placenta 2019 Jan 16;75:16-22. Epub 2018 Nov 16.

Institute of Special Animal and Plant Sciences, Chinese Academy of Agricultural Sciences, Changchun, China; State Key Laboratory for Molecular Biology of Special Economic Animal and Plant Science, Chinese Academy of Agricultural Sciences, Changchun, China.

Introduction: In mink, as many as 65% of embryos die during gestation. The causes and the mechanisms of embryonic mortality remain unclear. The purpose of our study was to examine global gene expression changes during embryo invasion in mink, and thereby to identify potential signaling pathways involved in implantation failure and early pregnancy loss. Read More

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http://dx.doi.org/10.1016/j.placenta.2018.11.004DOI Listing
January 2019
1 Read
2.710 Impact Factor

Changes of γδT cell subtypes during pregnancy and their influences in spontaneous abortion.

J Reprod Immunol 2019 Feb 25;131:57-62. Epub 2019 Jan 25.

Obstetrics and Gynecology Hospital, Fudan University, Shanghai, 200011, China; Department of Obstetrics and Gynecology of Shanghai Medical College, Fudan University, Shanghai, 200011, China; Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Shanghai, 200032, China; Key Laboratory of Reproduction Regulation of NPFPC, SIPPR, IRD, Shanghai 200032, China. Electronic address:

A successful pregnancy is a complicated process that involves the precisely timed regulation of endocrine as well as immune system. Despite increasing knowledge about immunology in gestation, the studies of immune cells in endometrium and decidua are still fragmented. Dynamic data is lacking on the transition of pre-pregnancy endometrial lymphocytes to initial pregnancy states as well as to second/third-trimester status. Read More

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http://dx.doi.org/10.1016/j.jri.2019.01.003DOI Listing
February 2019
1 Read

First Trimester Bleeding: Evaluation and Management.

Am Fam Physician 2019 Feb;99(3):166-174

University of Michigan Medical School, Ann Arbor, MI, USA.

Approximately one-fourth of pregnant women will experience bleeding in the first trimester. The differential diagnosis includes threatened abortion, early pregnancy loss, and ectopic pregnancy. Pain and heavy bleeding are associated with an increased risk of early pregnancy loss. Read More

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February 2019
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Combined treatment of McDonald cerclage and Arabin-pessary: a chance in the prevention of spontaneous preterm birth?

J Matern Fetal Neonatal Med 2019 Jan 30:1-9. Epub 2019 Jan 30.

a Department of Obstetrics and Gynecology , Buergerhospital and Clementine Childern's Hospital Frankfurt/Main , Frankfurt/Main , Germany.

Background: Patients with cervical shortening obtained by transvaginal ultrasound and/or previous preterm delivery are at increased risk for preterm birth in the current pregnancy. The aim of the present cohort study was to compare the rate of preterm birth and early neonatal parameters in patients at risk and screening patients who received either a cerclage or a combined treatment of cerclage and cervical pessary.

Methods: A retrospective cohort study was conducted from March 2005 to March 2017 including all patients in our department which received a McDonald cerclage or a combined treatment of McDonald cerclage and an Arabin pessary. Read More

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http://dx.doi.org/10.1080/14767058.2019.1570123DOI Listing
January 2019
1 Read

Pregnancy outcomes after removal of osmotic dilators in patients who presented for second-trimester abortion.

Contraception 2019 Jan 25. Epub 2019 Jan 25.

Department of Obstetrics and Gynecology, University of Maryland, Baltimore, MD.

Objective: To report pregnancy outcomes and potentially related complications among thirteen patients who had osmotic dilators placed for second-trimester dilation and evacuation followed by subsequent removal with the intention to continue their pregnancies.

Study Design: We reviewed billing and scheduling data between 2005 and 2017 to identify the total number of women seen for D&E and to identify the individuals who had dilators placed without a subsequent scheduled dilation and evacuation. We then performed chart reviews to determine pregnancy outcomes. Read More

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http://dx.doi.org/10.1016/j.contraception.2018.09.007DOI Listing
January 2019
2 Reads

Risk markers of reproductive loss in women with hyperandrogenism.

Wiad Lek 2018 ;71(8):1550-1553

Ukrainian Medical Stomatological Academy, Poltava, Ukraine.

Objective: Introduction: The frequency of the pathological course of pregnancy with hyperandrogenism ranges from 21 to 48%. With the predominance of androgens against the background of lowering the normal products of steroidogenesis, a pro-inflammatory immune imbalance is formed, which causes a premature termination of the development of pregnancy. Many studies indicate that hyperandrogenism is a factor in the development of obstetric pathology, including placental dysfunction. Read More

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January 2018
8 Reads

Obstetrical complications of thin endometrium in assisted reproductive technologies: a systematic review.

J Assist Reprod Genet 2019 Jan 25. Epub 2019 Jan 25.

Virginia Center for Reproductive Medicine, Reston, VA, USA.

Purpose: The aim of the systematic review is to describe the obstetrical complications associated with pregnancies in the context of a thin endometrial lining.

Methods: Systematic review of the literature.

Results: Patients who conceive in the setting of a thin endometrium have a significantly increased risk of early pregnancy loss, namely miscarriage and ectopic pregnancy. Read More

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http://dx.doi.org/10.1007/s10815-019-01407-yDOI Listing
January 2019
2 Reads

Gene polymorphism associated with endothelial nitric oxide synthase (4VNTR, G894T, C786T) and unexplained recurrent spontaneous abortion risk: A meta-analysis.

Medicine (Baltimore) 2019 Jan;98(4):e14175

Department of First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, China.

To evaluate the association between endothelial nitric oxide synthase gene polymorphisms (4VNTR A/B, G894T, C786T) and risk of URSA.Related case-control studies were collected by computers. A meta-analysis was conducted using Stata 12. Read More

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http://dx.doi.org/10.1097/MD.0000000000014175DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358376PMC
January 2019
8 Reads

Young Women with Breast Cancer: Fertility Preservation Options and Management of Pregnancy-Associated Breast Cancer.

Ann Surg Oncol 2019 Jan 24. Epub 2019 Jan 24.

Division of Surgical Oncology, Department of Surgery, University of Michigan, Ann Arbor, MI, USA.

Background: Breast cancer is the most common malignancy diagnosed in women of childbearing age. A breast cancer diagnosis in this young patient population can be uniquely complex to navigate when considering the potential impact of fertility loss associated with specific gonadotoxic therapies. Another unique challenge for young breast cancer patients is pregnancy-associated breast cancer (PABC), which occurs in approximately 1 of every 3000 pregnancies. Read More

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http://dx.doi.org/10.1245/s10434-019-07156-7DOI Listing
January 2019
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Clinical, Neuroimaging, and Neurophysiological Findings in Children with Microcephaly Related to Congenital Zika Virus Infection.

Int J Environ Res Public Health 2019 Jan 23;16(3). Epub 2019 Jan 23.

Post-graduate Programme in Health Sciences, Federal University of Bahia School of Medicine, Praça XV de Novembro-Largo do Terreiro de Jesus, 40025-010 Bahia, Brazil.

Zika virus (ZIKV) infection appeared in Brazil in 2015, causing an epidemic outbreak with increased rates of microcephaly and other serious birth disorders. We reviewed 102 cases of children who were diagnosed with microcephaly at birth and who had gestational exposure to ZIKV during the outbreak. We describe the clinical, neuroimaging, and neurophysiological findings. Read More

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http://www.mdpi.com/1660-4601/16/3/309
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http://dx.doi.org/10.3390/ijerph16030309DOI Listing
January 2019
3 Reads

Early first trimester transvaginal ultrasound is indicated in pregnancies after a previous cesarean delivery: should it be mandated?

Ultrasound Obstet Gynecol 2019 Jan 24. Epub 2019 Jan 24.

Department of Obstetrics, Gynecology, and Reproductive Science, Icahn School of Medicine at Mount Sinai, New York, New York.

In this opinion article, we provide compelling arguments of why early screening for pregnancies following previous cesarean delivery would be beneficial. First, we provide an overview of the perils of undiagnosed or misdiagnosed cesarean scar pregnancies (CSP), mostly with bleeding, but also with other complications, that may lead to multiple surgeries, uterine artery embolization, loss of fertility and in rare cases of documented deaths. There is well-documented histopathological connection between CSP and the placental adherence spectrum (PAS) suggesting that CSP is a precursor to PAS. Read More

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http://dx.doi.org/10.1002/uog.20225DOI Listing
January 2019
3 Reads

Treatment efficiency of comprehensive hysteroscopic evaluation and lesion resection combined with progestin therapy in young women with endometrial atypical hyperplasia and endometrial cancer.

Gynecol Oncol 2019 Jan 21. Epub 2019 Jan 21.

Department of Gynecology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai 200011, China; Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Shanghai 200011, China. Electronic address:

Objective: This study aimed to evaluate the efficacy of comprehensive hysteroscopic evaluation and lesion resection combined with progestin therapy in young patients with endometrial atypical hyperplasia (EAH) and early stage endometrial cancer (EEC) who wished to preserve their fertility.

Methods: Patients with EAH (n = 120) or well-differentiated EEC (n = 40, FIGO stage IA, without myometrial invasion) were retrospectively included. All patients received constant oral progestin combined with hysteroscopic evaluation every 3 months until achieving complete response (CR). Read More

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http://dx.doi.org/10.1016/j.ygyno.2019.01.014DOI Listing
January 2019
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Pregnancy outcomes in women with kidney transplant: Metaanalysis and systematic review.

BMC Nephrol 2019 Jan 23;20(1):24. Epub 2019 Jan 23.

Division of Neonatology, Cincinnati Children's Hospital and Medical Center, Cincinnati, OH, USA.

Background: Reproductive function in women with end stage renal disease generally improves after kidney transplant. However, pregnancy remains challenging due to the risk of adverse clinical outcomes.

Methods: We searched PubMed/MEDLINE, Elsevier EMBASE, Scopus, BIOSIS Previews, ISI Science Citation Index Expanded, and the Cochrane Central Register of Controlled Trials from date of inception through August 2017 for studies reporting pregnancy with kidney transplant. Read More

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http://dx.doi.org/10.1186/s12882-019-1213-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345071PMC
January 2019
7 Reads

Comparison of two bovine serum pregnancy tests in detection of artificial insemination pregnancies and pregnancy loss in beef cattle.

PLoS One 2019 23;14(1):e0211179. Epub 2019 Jan 23.

Department of Animal Science, South Dakota State University, Brookings, SD, United States of America.

Blood tests for early detection of pregnancy in cattle based on pregnancy-associated glycoproteins (PAGs) are commercially available. The objective of these studies were to compare the accuracy of blood tests to transrectal ultrasonography in detecting AI pregnancies, and to compare the accuracy of blood tests in predicting pregnancy loss. Beef cattle from 6 herds were synchronized using a recommended CIDR based protocol (Study 1: n = 460; Study 2: n = 472). Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0211179PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344102PMC
January 2019
1 Read

The risk of Helicobacter pylori infection for adverse pregnancy outcomes: A systematic review and meta-analysis.

Helicobacter 2019 Jan 22:e12562. Epub 2019 Jan 22.

School of Public Health, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.

Objective: To estimate the current evidence regarding the association between Helicobacter pylori infection during pregnancy and adverse pregnancy outcomes.

Materials And Methods: A systematic literature search for relevant publications was conducted using PubMed, EMBASE, Cochrane Library, and Web of science databases through November 17th, 2018. The pooled odds ratios (ORs) with their corresponding 95% confidence intervals (CIs) were selected as the effect size. Read More

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http://doi.wiley.com/10.1111/hel.12562
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http://dx.doi.org/10.1111/hel.12562DOI Listing
January 2019
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Combining and Using the Utrecht Method and the Analytic Hierarchy Process to Facilitate Professional and Ethical Deliberation and Decision Making in Complementary and Alternative Medicine: A Case Study among a Panel of Stakeholders.

Authors:
Ramzi Shawahna

Evid Based Complement Alternat Med 2018 23;2018:2315938. Epub 2018 Dec 23.

Department of Physiology, Pharmacology and Toxicology, Faculty of Medicine and Health Sciences, An-Najah National University, Nablus, State of Palestine.

Background: In daily practice, healthcare practitioners face many challenges in ethical and professional decision making. Currently, little is known on the ethical and professional deliberations and weighing benefits against risks in daily complementary and alternative medicine (CAM) practice. The aim of this study was to combine the Utrecht method and the Analytic Hierarchy Process (AHP) in deliberations, weighing benefits against risks of using ginger for a pregnant woman suffering nausea and vomiting of pregnancy (NVP) along with other comorbidities. Read More

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http://dx.doi.org/10.1155/2018/2315938DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323446PMC
December 2018

Decidual Interleukin-22-Producing CD4+ T Cells (Th17/Th0/IL-22+ and Th17/Th2/IL-22+, Th2/IL-22+, Th0/IL-22+), Which Also Produce IL-4, Are Involved in the Success of Pregnancy.

Int J Mol Sci 2019 Jan 19;20(2). Epub 2019 Jan 19.

Department of Experimental and Clinical Medicine and DENOTHE Excellence Center, University of Florence, 50134 Florence, Italy.

Trophoblast expressing paternal HLA-C resembles a semiallograft, and could be rejected by maternal T cells. IL-22 seems to be involved in allograft rejection and thus could be responsible for miscarriages. We examined the role of decidual IL-22-producing CD4+ T on human pregnancy. Read More

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http://dx.doi.org/10.3390/ijms20020428DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359245PMC
January 2019
1 Read