4,120 results match your criteria Early Human Development[Journal]


Body composition and cognition in preschool-age children with congenital gastrointestinal anomalies.

Early Hum Dev 2018 Dec 15;129:5-10. Epub 2018 Dec 15.

Division of Neonatology, Department of Pediatrics, University of Minnesota, Minneapolis, MN, United States.

Background: Children with congenital gastrointestinal anomalies (CGIAs) experience multiple stressors while hospitalized in neonatal intensive care units during an essential time of growth and development. Early stress and inadequate nutrition are linked to altered growth patterns and later neurodevelopmental delays. In other at-risk populations, improved fat-free mass (FFM) accretion is associated with improved cognitive outcomes. Read More

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http://dx.doi.org/10.1016/j.earlhumdev.2018.12.001DOI Listing
December 2018

Association between prenatal opioid exposure, neonatal opioid withdrawal syndrome, and neurodevelopmental and behavioral outcomes at 5-8 months of age.

Early Hum Dev 2018 Dec 13;128:69-76. Epub 2018 Dec 13.

Department of Family and Community Medicine, School of Medicine, University of New Mexico, Albuquerque, NM, United States of America.

Background: While use of prescription opioids and medication assisted therapy (MAT) for opioid use disorder in pregnancy, as well as the incidence of neonatal opioid withdrawal syndrome (NOWS) continue to rise, little is known about outcomes for children with NOWS beyond the newborn period.

Methods: We examined 1) prenatal MAT exposure vs. unexposed healthy controls [HC]; and 2) treatment for NOWS and NOWS severity on infant neurodevelopmental and behavioral outcomes at 5-8 months of age in 78 maternal-infant pairs from the ENRICH prospective cohort study. Read More

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http://dx.doi.org/10.1016/j.earlhumdev.2018.10.010DOI Listing
December 2018

Write a Scientific Paper (WASP) - What can I publish [1]? Types of studies.

Authors:
Victor Grech

Early Hum Dev 2018 Dec 10. Epub 2018 Dec 10.

Academic Department of Paediatrics, Mater Dei Hospital, Malta. Electronic address:

As an experienced writer, one is often asked the question "what can I publish" by younger and inexperienced colleagues who must publish. This paper will briefly review the reasons why academics publish and will then outline what kind of papers one may be able to publish with relative ease, using personal experience and citing first hand material as a practical guide. Potential authors must cultivate "a lean and hungry look" as competition from fellow writers is stiff, and editors are choosy. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03783782183072
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http://dx.doi.org/10.1016/j.earlhumdev.2018.12.003DOI Listing
December 2018
3 Reads

Write a Scientific Paper (WASP): Academic hoax and fraud.

Authors:
Victor Grech

Early Hum Dev 2018 Dec 10. Epub 2018 Dec 10.

University of Malta, Msida, Malta; Mater Dei Hospital, Msida, Malta. Electronic address:

Academics may deliberately hoax colleagues with false research, so as to forcibly and dramatically make a particular point. Moreover, false research may a process of deliberate and outright fraud. This paper will review a few examples as cautionary tales for academics and researchers. Read More

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http://dx.doi.org/10.1016/j.earlhumdev.2018.12.005DOI Listing
December 2018

Past and anticipated trends in cardiology service requirements at Mater Dei Hospital, Malta.

Early Hum Dev 2018 Dec 10. Epub 2018 Dec 10.

Mater Dei Hospital, Malta. Electronic address:

Introduction: The requirement for medical services fluctuates. This study was carried out in order to attempt to extrapolate the service requirements for various cardiology services at Mater Dei Hospital, Malta over the coming five years, based on service demands from previous years.

Methods: Past annual data was obtained from hospital records for various services (to 2017). Read More

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December 2018
1 Read

Audiovisual speech perception and language acquisition in preterm infants: A longitudinal study.

Early Hum Dev 2018 Dec 8. Epub 2018 Dec 8.

Graduate School of Education, Kyoto University, Kyoto, Japan.

Background: Preterm infants have a higher risk of language delay throughout childhood. The ability to integrate audiovisual speech information is associated with language acquisition in term infants; however, the relation is still unclear in preterm infant.

Aim And Methods: This study longitudinally investigated visual preference for audiovisual congruent and incongruent speech during a preferential looking task using eye-tracking in preterm and term infants at 6, 12, and 18 months of corrected age. Read More

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http://dx.doi.org/10.1016/j.earlhumdev.2018.11.001DOI Listing
December 2018

Write a Scientific Paper (WASP): An overview of differences in styles between the sciences and the humanities.

Authors:
Victor Grech

Early Hum Dev 2018 Dec 8. Epub 2018 Dec 8.

University of Malta, Msida, Malta; Mater Dei Hospital, Msida, Malta. Electronic address:

Researchers who cross a discipline may experience culture shock at the different worlds of science and medicine. This paper outlines the differences in concepts and philosophies and in presentation styles. The acute difficulties when attempting to read or write works in different disciplines are also addressed, as well as the differences in perceptions and values when approaching written works in unfamiliar branches of academia. Read More

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http://dx.doi.org/10.1016/j.earlhumdev.2018.12.008DOI Listing
December 2018

Telomere length and salivary cortisol stress reactivity in very preterm infants.

Early Hum Dev 2018 Dec 6;129:1-4. Epub 2018 Dec 6.

0-3 Center for the at-Risk Infant, Scientific Institute IRCCS Eugenio Medea, via Don Luigi Monza 20, 23842 Bosisio Parini, Lecco, Italy.

During the Neonatal Intensive Care Unit (NICU) stay, very preterm (VPT) infants are exposed to life-saving yet pain-inducing skin-breaking procedures (i.e., NICU pain-related stress) which contribute to the programming of hypo-responsive HPA axis development during the first months of life. Read More

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http://dx.doi.org/10.1016/j.earlhumdev.2018.12.002DOI Listing
December 2018
2 Reads

Digit ratio (2D:4D) moderates the change in handgrip strength on an aggressive stimulus: A study among Polish young adults.

Early Hum Dev 2018 Dec 6;128:62-68. Epub 2018 Dec 6.

Department of Anthropology, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wroclaw, Poland. Electronic address:

Background: The ratio of the lengths of second finger (2D) to the fourth (4D) is a putative indicator of foetal hormonal exposure. The link between 2D:4D and physical strength or sports performance in not consistent. It was suggested that the association of 2D:4D with the sporting and physical ability is better demonstrated in the context of challenge and competition, either real or simulated. Read More

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http://dx.doi.org/10.1016/j.earlhumdev.2018.11.009DOI Listing
December 2018

Reliability and agreement of ages and stages questionnaires®: Results in late preterm and term-born infants at 24 and 48 months.

Early Hum Dev 2018 Dec 4;128:55-61. Epub 2018 Dec 4.

SCIAS, Hospital de Barcelona, Barcelona, Spain.

Aim: To evaluate the reliability of the Ages and Stages Questionnaires (ASQ-3) 24 and 48 month intervals translated to Spanish by Brookes Publishing, and the agreement between both questionnaires, comparing late preterm (LPI) and term-born infants (terms).

Methods: Two cohort samples of healthy LPI and terms that were born in a private hospital in Barcelona, Spain. Internal consistency was analyzed by Cronbach's alpha scores and Pearson product- moment correlation between the domain scores and the overall score. Read More

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http://dx.doi.org/10.1016/j.earlhumdev.2018.11.008DOI Listing
December 2018

Write a Scientific Paper (WASP) - what can I publish (2)? Hierarchies of evidence.

Early Hum Dev 2018 Dec 7. Epub 2018 Dec 7.

University of Malta, Consultant Paediatric Cardiologist, Mater Dei Hospital, Msida, Malta. Electronic address:

Evidence-based published data is the prime source used for clinical decision making, the issuance of guidelines and the drafting new policies. A number of different study designs are used to perform and publish research studies, corresponding to the research question being investigated. Over the decades, a hierarchical system of evidence has been established. Read More

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http://dx.doi.org/10.1016/j.earlhumdev.2018.12.004DOI Listing
December 2018

Behavioral problems are associated with cognitive and language scores in toddlers born extremely preterm.

Early Hum Dev 2018 Dec 3;128:48-54. Epub 2018 Dec 3.

Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.

Objective: To evaluate the relationship of parent-reported child behaviors on the Child Behavior Checklist (CBCL) to cognition, language, and motor skills on the Bayley Scales of Infant and Toddler Development - III (Bayley-III) in toddlers born extremely preterm.

Study Design: Toddlers born extremely preterm (gestational ages 22 0/7 to 26 6/7 weeks) were tested at 22-26 months corrected age with Bayley-III while parents completed the CBCL. Socio-demographic variables and medical history were recorded. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03783782183056
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http://dx.doi.org/10.1016/j.earlhumdev.2018.11.007DOI Listing
December 2018
5 Reads

Associations of gestational age with child health and neurodevelopment among twins: A nationwide Japanese population-based study.

Early Hum Dev 2018 Nov 20;128:41-47. Epub 2018 Nov 20.

Department of Neonatology, Okayama Medical Center, National Hospital Organization, Okayama, Japan.

Background: The prevalence of multiple births has recently increased. However, the association between gestational age and long-term morbidity among twins remains unclear.

Aims: To examine the association of gestational age with child health and neurological development in early childhood among twins. Read More

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http://dx.doi.org/10.1016/j.earlhumdev.2018.11.005DOI Listing
November 2018

Left ventricular diastolic function influences right ventricular - Pulmonary vascular coupling in premature infants.

Early Hum Dev 2018 Nov 19;128:35-40. Epub 2018 Nov 19.

Department of Pediatrics, Washington University School of Medicine, Saint Louis, MO, USA; Division of Newborn Medicine, Boston Children's Hospital, Boston, MA, USA. Electronic address:

Introduction: Reduced left ventricular (LV) diastolic function can exert significant load to the right ventricle (RV) that can affect RV-pulmonary vasculature (PV) coupling. RV-PV can be assessed with the RV length-force relationship (tricuspid annular plane systolic excursion [TAPSE] to pulmonary artery acceleration time [PAAT] ratio). We aimed to determine the association between LV diastolic function measured using tissue Doppler imaging (TDI) and TAPSE/PAAT. Read More

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http://dx.doi.org/10.1016/j.earlhumdev.2018.11.006DOI Listing
November 2018
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Educational achievement of children with congenital heart disease: Promising results from a survey by the German National Register of Congenital Heart Defects.

Early Hum Dev 2018 Nov 15;128:27-34. Epub 2018 Nov 15.

Department of Congenital Heart Disease - Paediatric Cardiology, Deutsches Herzzentrum Berlin, Germany; DZHK (German Centre for Cardiovascular Research), partner site Berlin, Germany.

Background: Survival rates of children with congenital heart disease (CHD) have increased significantly in the decade. There is now increased interest in the long-term outcome and quality of life of these children.

Aims: To assess the educational achievement of patients with CHD in Germany. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03783782173064
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http://dx.doi.org/10.1016/j.earlhumdev.2018.11.003DOI Listing
November 2018
2 Reads

A 6-year longitudinal study: Are maternal depressive symptoms and Selective Serotonin Reuptake Inhibitor (SSRI) antidepressant treatment during pregnancy associated with everyday measures of executive function in young children?

Early Hum Dev 2018 Nov 14;128:21-26. Epub 2018 Nov 14.

Department of Pediatrics, University of British Columbia, BC Children's Hospital Research Institute, Canada; School of Population and Public Health, University of British Columbia, BC Children's Hospital Research Institute, Canada.

Background: Building on research reports that early and chronic exposure to maternal depressive symptoms (MDS) adversely affects children's developing executive function (EF), this longitudinal study examined whether exposure to MDS and Selective Serotonin Reuptake Inhibitor (SSRI) antidepressant treatment during pregnancy predicted individual differences in EF at school age.

Methods: In a longitudinal prospective cohort, maternal report of EF using the Behavior Rating Inventory of EF (BRIEF) was obtained from 139 children (77 females; non-exposed n = 88, SSRI exposed n = 51) at age 6 years. Clinician rated and self reports of MDS were also obtained spanning from the 2nd trimester to 6 years postpartum. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03783782183047
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http://dx.doi.org/10.1016/j.earlhumdev.2018.10.009DOI Listing
November 2018
2 Reads

Maternal anemia and pediatric neurological morbidity in the offspring - Results from a population based cohort study.

Early Hum Dev 2018 Nov 13;128:15-20. Epub 2018 Nov 13.

Department of Obstetrics and Gynecology, Soroka University Medical Center, Ben-Gurion University of the Negev, Beer-Sheva, Israel.

Objective: Maternal anemia (Hemoglobin, <11 mg/dl) has been shown to affect fetal growth and pregnancy outcome. We aimed to study a possible association between maternal anemia and the risk for neurological morbidity in the offspring, during a follow-up period of up to 18 years.

Study Design: A population-based cohort analysis was performed at the Soroka University Medical Center (SUMC), a single regional tertiary center comparing total and specific subtypes of neurological morbidities associated with hospitalizations among children stratified by three maternal post-partum hemoglobin categories: ≥11 mg/dl (no anemia); 11. Read More

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http://dx.doi.org/10.1016/j.earlhumdev.2018.11.002DOI Listing
November 2018
2 Reads
1.931 Impact Factor

Congenital diaphragmatic hernia in newborn infants: Variable endotracheal tube and umbilical venous catheter positions.

Early Hum Dev 2018 Nov 10;128:12-14. Epub 2018 Nov 10.

Women and Children's Health, School of Life Course Sciences, Faculty of Life Sciences and Medicine, King's College London, UK; MRC-Asthma UK Centre in Allergic Mechanisms of Asthma, King's College London, UK; National Institute for Health Research (NIHR) Biomedical Research Centre Based at Guy's and St. Thomas' NHS Foundation Trust and King's College London, UK.

We reviewed the radiographs of 131 infants with congenital diaphragmatic hernia and report that the umbilical venous catheter usually deviates to the ipsilateral and the endotracheal tube to the contralateral side of the defect. The trachea and the umbilical vein, however, can be found on either side of the midline. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03783782183065
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http://dx.doi.org/10.1016/j.earlhumdev.2018.11.004DOI Listing
November 2018
6 Reads
1.931 Impact Factor

Dermatoglyphics in children prenatally exposed to alcohol: Fluctuating asymmetry (FA) as a biomarker of alcohol exposure.

Early Hum Dev 2018 Dec 28;127:90-95. Epub 2018 Oct 28.

Secció de Zoologia i Antropologia Biològica, Departament de Biologia Evolutiva, Ecologia i Ciències Ambientals, Facultat de Biologia, Universitat de Barcelona (UB), Barcelona, Spain; Institut de Biomedicina de la Universitat de Barcelona (IBUB), Barcelona, Spain; Centre for Biomedical Research Network on Mental Health (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain. Electronic address:

Background: Dermatoglyphics alterations have been demonstrated to be an effective complement in the diagnosis of developmental disorders and a marker of prenatal stress. Several genetic and environmental factors can modify their morphology. Once defined, dermatoglyphics remain constant throughout life, being considered fossilized markers of the intrauterine development. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03783782183035
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http://dx.doi.org/10.1016/j.earlhumdev.2018.10.007DOI Listing
December 2018
5 Reads

Physical fitness of non-disabled school-aged children born with extremely low birth weights.

Early Hum Dev 2018 Oct 27;128:6-11. Epub 2018 Oct 27.

Department of Neonatal Medicine, Osaka Women's and Children's Hospital, 840 Murodo-cho, Izumi, Osaka 594-1101, Japan. Electronic address:

Background: The assessment of long-term outcomes in survivors born with extremely low birth weights (ELBWs) has become increasingly important. However, little has been reported on the physical fitness of non-disabled school-aged children born with ELBWs.

Aims: To assess the physical fitness of non-disabled school-aged children born with ELBWs. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03783782183019
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http://dx.doi.org/10.1016/j.earlhumdev.2018.10.008DOI Listing
October 2018
8 Reads

Correspondence regarding "Outcomes of preterm infants treated with hypothermia for hypoxic-ischemic encephalopathy".

Early Hum Dev 2018 Oct 29. Epub 2018 Oct 29.

Division of Neonatology, Department of Pediatrics, Duke University School of Medicine, Durham, NC, United States of America.

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http://dx.doi.org/10.1016/j.earlhumdev.2018.09.014DOI Listing
October 2018
1 Read

Factors influencing decision-making: Delayed hypothermia in a late preterm infants with hypoxic-ischemic encephalopathy.

Early Hum Dev 2018 Oct 18. Epub 2018 Oct 18.

Department of Pediatrics, University of California at Davis, Sacramento, CA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.earlhumdev.2018.10.006DOI Listing
October 2018

Delayed theory of mind development in children born preterm: A longitudinal study.

Early Hum Dev 2018 Dec 17;127:85-89. Epub 2018 Oct 17.

TU Dortmund University, Dortmund, Germany.

Background: Children born preterm are at high risk of developmental delay in various cognitive domains. Moreover, problems in social interaction are more frequently reported in preterm children than in their full-term peers. These difficulties can be observed at two years of age and seem to persist until school age. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03783782183053
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http://dx.doi.org/10.1016/j.earlhumdev.2018.10.005DOI Listing
December 2018
3 Reads

Background EEG features and prediction of cognitive outcomes in very preterm infants: A systematic review.

Early Hum Dev 2018 Dec 16;127:74-84. Epub 2018 Oct 16.

The University of Queensland, UQ Centre for Clinical Research, Brisbane, Australia; The University of Queensland, Perinatal Research Centre, Faculty of Medicine, Brisbane, Australia.

Objectives: Very preterm infants are at risk of cognitive impairment, but current capacity to predict at-risk infants is sub-optimal. Electroencephalography (EEG) has been used to assess brain function in development. This review investigates the relationship between EEG and cognitive outcomes in very preterm infants. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03783782183044
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http://dx.doi.org/10.1016/j.earlhumdev.2018.09.015DOI Listing
December 2018
5 Reads

Academic challenges for the preterm infant: Parent and educators' perspectives.

Early Hum Dev 2018 Oct 13;128:1-5. Epub 2018 Oct 13.

University of Toronto, Department of Paediatrics, 27 King's College Cir, Toronto, ON M5S 3H7, Canada; Mount Sinai Hospital, Department of Paediatrics, 600 University Avenue, Toronto, ON M5G 1X5, Canada; Maternal-Infant Care Research Centre, Mount Sinai Hospital, 700 University Avenue, Suite 8-500, Toronto, ON M5G 1X6, Canada.

Background: Little is known of educators' knowledge of the impact of preterm birth on academic achievement and nothing is known of parental perspective of this knowledge.

Aims: To examine the knowledge of the impact of preterm birth on academic achievement amongst Canadian educators, characterize educators' attitudes towards these challenges, and examine parental perspectives of the educational system for their preterm child.

Study Design And Methods: This was a mixed methods study involving kindergarten to Grade 3 educators and parents of preterm children aged 4-8 years. Read More

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http://dx.doi.org/10.1016/j.earlhumdev.2018.09.016DOI Listing
October 2018

Is kangaroo mother care effective in alleviating vaccination associated pain in early infantile period? A RCT.

Early Hum Dev 2018 Dec 12;127:69-73. Epub 2018 Oct 12.

Department of Neonatology, SGPGI, Lucknow, India.

Background: Childhood vaccination is a common procedure and a part of routine medical care during infancy. Although vaccination is the cornerstone for prevention of many infectious diseases, it is associated with significant pain, which is often ignored. Non pharmacological interventions such as breast feeding and kangaroo mother care (KMC) have been used to decrease this procedural pain. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03783782183033
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http://dx.doi.org/10.1016/j.earlhumdev.2018.10.001DOI Listing
December 2018
1 Read

The receptor for hyaluronan-mediated motility (RHAMM) expression in neonatal bronchiolar epithelium correlates negatively with lung air content.

Early Hum Dev 2018 Dec 10;127:58-68. Epub 2018 Oct 10.

Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden.

Introduction: Hyaluronan (HA) and the receptor for hyaluronan-mediated motility (RHAMM) may play an important role in lung development. We examined the expression of HA content and RHAMM during postnatal lung development by analyzing human lung specimens from newborn infants with a variety of lung diseases at different gestational (GA) and postnatal (PNA) ages.

Materials And Methods: Ninety-four patients were evaluated. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03783782183019
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http://dx.doi.org/10.1016/j.earlhumdev.2018.10.002DOI Listing
December 2018
6 Reads

Predictors of hospitalization for acute lower respiratory infections during the first two years of life in a population of preterm infants with bronchopulmonary dysplasia.

Early Hum Dev 2018 Dec 9;127:53-57. Epub 2018 Oct 9.

Department of Pediatrics, School of Medicine, Universidad Nacional de Colombia, Cra 45 No. 26-85, Bogotá, Colombia; Department of Pediatric Pulmonology and Pediatric Critical Care Medicine, School of Medicine, Universidad El Bosque, Av Cra 9 No. 131A-02, Bogotá, Colombia. Electronic address:

Background: There have been few research studies aimed at obtaining a better understanding of the prediction of subsequent respiratory morbidity at follow-up in infants with a previous history of bronchopulmonary dysplasia (BPD) living in low- and middle-income countries (LMIC). The aim of the present study was to identify predictors of hospitalization for acute lower respiratory infections (ALRIs) in a population of infants with a history of BPD living in a LMIC.

Methods: In a prospective cohort study, we determined independent predictors of the number of hospitalizations for ALRIs during the first two years of life in a population of infants with a history of BPD living in Bogota, Colombia. Read More

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http://dx.doi.org/10.1016/j.earlhumdev.2018.10.003DOI Listing
December 2018
3 Reads

The intra-assay reproducibility of thromboelastography in very low birth weight infants.

Early Hum Dev 2018 Dec 9;127:48-52. Epub 2018 Oct 9.

Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Università degli Studi di Milano, Italy. Electronic address:

Background And Aims: Despite the potential benefits of thromboelastography (TEG) for bedside hemostatic assessment in critical care settings, its accuracy remains to be determined, especially in critically ill neonates. We determined the intra-assay reproducibility of TEG parameters: Reaction time (R), clot kinetics (K) and Maximum Amplitude (MA) in a cohort of very low birth weight (VLBW) infants.

Study Design: Observational study. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03783782183022
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http://dx.doi.org/10.1016/j.earlhumdev.2018.10.004DOI Listing
December 2018
1 Read

The relationship between exclusive breastfeeding and infant development: A 6- and 12-month follow-up study.

Early Hum Dev 2018 Dec 4;127:42-47. Epub 2018 Oct 4.

Sesalmaul Research Institute, Gachon University, Gyeonggi-do, South Korea; Department of Early Childhood Education, Gachon University, Gyeonggi-do, South Korea. Electronic address:

Background: Breastfeeding offers several advantages for infants with research suggesting that it benefits development, including cognitive and language development. However, limited research has examined the benefits in infants under one year.

Aims: To investigate the association between breastfeeding duration and infant development. Read More

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http://dx.doi.org/10.1016/j.earlhumdev.2018.08.011DOI Listing
December 2018

Sudden unexpected postnatal collapse.

Early Hum Dev 2018 Nov 25;126:28-31. Epub 2018 Sep 25.

Department of Neonatology, Simpson Centre for Reproductive Health, Royal Infirmary of Edinburgh, EH16 4SA, United Kingdom. Electronic address:

This review of Sudden Unexpected Postnatal Collapse (SUPC) highlights the challenges in definition and nomenclature that currently exist. In comparing SUPC with Sudden Unexpected Death in Infancy (SUDI), the potentially avoidable nature of many SUPC is emphasised and the role of positioning and public awareness explored. The article focusses on the implementation of preventative strategies in the immediate postnatal period and the role of therapeutic hypothermia in ameliorating long term neurological injury. Read More

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http://dx.doi.org/10.1016/j.earlhumdev.2018.09.001DOI Listing
November 2018
7 Reads

Erratum to "Neuropredictors of oromotor feeding impairment in 12 month-old children" [Early Hum. Dev. (2017) 49-55].

Early Hum Dev 2018 Sep 24. Epub 2018 Sep 24.

Murdoch Childrens Research Institute, Parkville, VIC 3052, Australia; University of Melbourne, Parkville, VIC 3052, Australia; Royal Women's Hospital, Parkville, VIC 3052, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.earlhumdev.2018.09.013DOI Listing
September 2018
1 Read

Bradycardias are associated with more severe effects on cerebral oxygenation in very preterm infants than in late preterm infants.

Early Hum Dev 2018 Dec 20;127:33-41. Epub 2018 Sep 20.

The Ritchie Centre, Hudson Institute of Medical Research, Department of Paediatrics, Monash University, Melbourne, Australia; Monash Newborn, Monash Children's Hospital, Melbourne, Australia. Electronic address:

Background: Commonly the magnitude and frequency of bradycardia is underestimated in the neonatal unit due to the long averaging time used in bedside oximeters. We aimed to assess the frequency and severity of bradycardia in preterm infants using the lowest averaging time (2 s) available on a clinical oximeter, compared with bradycardia detected using electrocardiogram (ECG), and whether bradycardia severity and postmenstrual age affected cerebral oxygenation.

Methods: Preterm infants (10 M/9F) were studied longitudinally at 26-31 (very preterm) and 32-38 weeks (late preterm) postmenstrual age. Read More

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http://dx.doi.org/10.1016/j.earlhumdev.2018.08.008DOI Listing
December 2018

WASP (Write a Scientific Paper): Miscellaneous practical and material aspects.

Authors:
Victor Grech

Early Hum Dev 2018 Sep 18. Epub 2018 Sep 18.

Medical School, University of Malta, Msida, Malta. Electronic address:

To date, these WASP (Write a Scientific Paper) Best Practice Guidelines have dealt with various aspects of conducting research and writing it up. The papers in this set will review some practical and material aspects related to paper writing, particularly those pertaining to online resources that may potentially be utilized for research, how to structure a scientific paper using the conventional IMRaD (Introduction - Method - Results - and - Discussion) format, the use of bibliographic software for handling references, and the practicalities of dealing with a pathology lab for research purposes. Read More

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http://dx.doi.org/10.1016/j.earlhumdev.2018.09.008DOI Listing
September 2018

WASP (Write a Scientific Paper): The use of bibliographic management software.

Early Hum Dev 2018 Sep 18. Epub 2018 Sep 18.

Public Health Department, University of Malta, Msida, Malta; Directorate for Health Information and Research, Gwardamanga, Malta. Electronic address:

In the scholarly environment, research findings are disseminated as journal papers which support/dispute extant knowledge or add further to what is already known. The entire manuscript needs to be cited (in-text) and referenced (at the end of article), in order for readers to ascertain the validity of the research claim/s. This must be done in proper and accepted fashion as plagiarism is a serious misdeed and inappropriate referencing mars a paper. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03783782183059
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http://dx.doi.org/10.1016/j.earlhumdev.2018.09.012DOI Listing
September 2018
7 Reads

WASP (Write a Scientific Paper): A review on the online medical resources available for medical training.

Authors:
Sarah Cuschieri

Early Hum Dev 2018 Sep 18. Epub 2018 Sep 18.

Anatomy Department, University of Malta, Msida, Malta. Electronic address:

The global contemporary shift from paper-based to digital online resources has led to a revolutionary change in medical training. A multitude of online resources have been developed over the years that complement the medical professional's education, with greater access to knowledge, while enabling continuous medical education and development. These sources also allow us to keep up-to-date with medical news. Read More

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http://dx.doi.org/10.1016/j.earlhumdev.2018.09.009DOI Listing
September 2018

Selective or universal screening for GBS in pregnancy (review).

Early Hum Dev 2018 Nov 18;126:18-22. Epub 2018 Sep 18.

MRC Centre for Reproductive Health, Queen's Medical Research Institute, University of Edinburgh, Edinburgh EH16 4TJ, UK. Electronic address:

Group B streptococcus (GBS) is the most common cause of early-onset neonatal sepsis in many countries and responsible for significant perinatal morbidity and mortality worldwide. Intrapartum antibiotic prophylaxis has been the mainstay of efforts to prevent early-onset GBS disease in recent decades, however it is unclear if women should be targeted based on the presence of clinical risk factors or by screening for GBS colonisation during pregnancy. Universal bacteriological screening of women in late pregnancy has been widely adopted but questions remain regarding its benefits and potential harms. Read More

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http://dx.doi.org/10.1016/j.earlhumdev.2018.09.002DOI Listing
November 2018
4 Reads

WASP (Write a Scientific Paper): The role of the pathology department in clinical research.

Early Hum Dev 2018 Sep 18. Epub 2018 Sep 18.

Mater Dei Hospital, Msida, Malta. Electronic address:

The pathology laboratory is the hub of investigatory medical care, and constitutes an invaluable asset for clinical research. A number of disciplines fall under the cap of a pathology laboratory. Researchers may gain access to such services provided ethical and laboratory administrative permissions have been granted. Read More

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http://dx.doi.org/10.1016/j.earlhumdev.2018.09.010DOI Listing
September 2018

WASP (Write a Scientific Paper): Structuring a scientific paper.

Early Hum Dev 2018 Sep 18. Epub 2018 Sep 18.

Faculty of Medicine & Surgery at University of Malta, Malta. Electronic address:

Writing and publishing scientific papers have become requisites for all scientists (researchers and academics alike) to maintain their professional career. The prospects of writing a scientific paper are often regarded as somewhat daunting to the uninitiated. However a universal, well established structure format known as "IMRAD": i. Read More

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http://dx.doi.org/10.1016/j.earlhumdev.2018.09.011DOI Listing
September 2018

Science of cryopreservation in reproductive medicine - Embryos and oocytes as exemplars.

Early Hum Dev 2018 Nov 14;126:6-9. Epub 2018 Sep 14.

Divison of Surgery & Interventional Science, Royal Free London NHS Trust & UCL, Royal Free Campus, London NW3 2QG, UK. Electronic address:

The modern successes of reproductive medicine are based on the achievements in the fields of artificial fertilization and cryobiology over the last 50years. Cryopreservation of oocytes makes it possible to preserve their reproductive potential after surgical interventions, treatment of cancer, for delayed pregnancy and to use cells for donation. Cryopreservation of embryos allows not only to reduce the multiple pregnancies rate and to increase the cumulative pregnancy rate as a result of embryo transfer in the following favorable cycles of the patient, but is also a necessary procedure in case of genetic diagnosis or in the case of contraindications for embryo transfer in the stimulated cycle due to possible complications. Read More

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http://dx.doi.org/10.1016/j.earlhumdev.2018.08.016DOI Listing
November 2018
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Direct versus indirect measurement of digit ratio: New data from Austria and a critical consideration of clarity of report in 2D:4D studies.

Early Hum Dev 2018 Dec 15;127:28-32. Epub 2018 Sep 15.

Applied Sports, Technology, Exercise, and Medicine (A-STEM), Swansea University, Swansea, United Kingdom.

Background: Digit ratio (2D:4D), has been the subject of many studies. However, the best method of measuring digit length, either directly (d2D:4D) or indirectly (i2D:4D), is controversial. In many reports i2D:4D has been found to show a directional effect such that d2D:4D > i2D:4D. Read More

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http://dx.doi.org/10.1016/j.earlhumdev.2018.09.007DOI Listing
December 2018
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Profiles and predictors of risk for developmental delay: Insights gained from a community-based universal screening program.

Early Hum Dev 2018 Dec 13;127:21-27. Epub 2018 Sep 13.

Family Futures, 678 Front Ave., NW, #210, Grand Rapids, MI 49504, USA. Electronic address:

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http://dx.doi.org/10.1016/j.earlhumdev.2018.09.003DOI Listing
December 2018
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On stopping rules and the sex ratio at birth.

Early Hum Dev 2018 Dec 13;127:15-20. Epub 2018 Sep 13.

Department of Mathematics, University of Malta, Malta. Electronic address:

One popular stopping rule intended to increase the rate of male births is to keep having babies until the first male is born. We show that such a stopping rule does not change the sex ratio at birth when the probability p that a birth produces a male is constant across a population. We show, however, that when p varies across couples, as evidence suggests that it does in the human population, with mean around 0. Read More

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http://dx.doi.org/10.1016/j.earlhumdev.2018.09.005DOI Listing
December 2018

Human interaction in the NICU and its association with outcomes on the Brief Infant-Toddler Social and Emotional Assessment (BITSEA).

Early Hum Dev 2018 Dec 13;127:6-14. Epub 2018 Sep 13.

Department of Psychology and Neuropsychology, Nationwide Children's Hospital, Columbus, OH, United States of America.

Background: Extremely preterm infants represent one of the highest risk categories for impairments in social competence. Few studies have explored the impact of the neonatal intensive care unit (NICU) environment on social development. However, none have specifically analyzed the effects of the care structure the infant receives during hospitalization on later social competence indicators. Read More

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http://dx.doi.org/10.1016/j.earlhumdev.2018.08.010DOI Listing
December 2018

Management of antenatally detected kidney malformations.

Early Hum Dev 2018 Nov 10;126:38-46. Epub 2018 Sep 10.

Fetal Medicine Unit, Elizabeth Garrett Anderson Hospital, University College Hospitals London, Huntley Street, London WC1N 6AU, UK; Nephro-Urology Group, Developmental Biology and Cancer programme, University College London Great Ormond Street Institute of Child Health, 30 Guildford Street, London WC1N 1EH, UK. Electronic address:

Congenital anomalies of the kidneys and the urinary tract (CAKUT) are one of the most common sonographically identified antenatal malformations. Dilatation of the renal pelvis accounts for the majority of cases, but this is usually mild rather than an indicator of obstructive uropathy. Other conditions such as small through large hyperechogenic and/or cystic kidneys present a significant diagnostic dilemma on routine scanning. Read More

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http://dx.doi.org/10.1016/j.earlhumdev.2018.08.017DOI Listing
November 2018

The case for a chronobiological approach to neonatal care.

Early Hum Dev 2018 Nov 8;126:1-5. Epub 2018 Sep 8.

Division of Neonatology, Department of Paediatrics, Erasmus Medical Center, Rotterdam, Netherlands. Electronic address:

Time of day is a critical factor for most biological functions, but concepts from the field of chronobiology have yet to be fully translated to clinical practice. Circadian rhythms, generated internally and synchronised to the external environment, promote function and support survival in almost every living species. Fetal circadian rhythms can be observed in utero from 30weeks gestation, coupled to the maternal rhythm, but synchronise to the external environment only after birth. Read More

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http://dx.doi.org/10.1016/j.earlhumdev.2018.08.012DOI Listing
November 2018
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Investigation and management of the long-term ventilated premature infant.

Early Hum Dev 2018 Nov 8;126:10-17. Epub 2018 Sep 8.

Department of Respiratory Paediatrics, Great Ormond Street Hospital for Children, Great Ormond Street, London WC1N 3JH, UK. Electronic address:

Bronchopulmonary dysplasia (BPD) is a common complication of prematurity, and despite significant advances in neonatal care over recent decades its incidence has not diminished. Although most affected infants have mild disease requiring a short period of oxygen supplementation or respiratory support, severely affected infants can become dependent on positive pressure support for a prolonged duration. In such cases, investigations should be carried out to ascertain whether there are secondary disease processes exacerbating the child's respiratory status. Read More

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http://dx.doi.org/10.1016/j.earlhumdev.2018.08.015DOI Listing
November 2018
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Intrauterine growth restriction and later cardiovascular function.

Early Hum Dev 2018 Nov 8;126:23-27. Epub 2018 Sep 8.

Fetal Medicine Research Center, BCNatal - Barcelona Center for Maternal-Fetal and Neonatal Medicine (Hospital Clínic and Hospital Sant Joan de Deu), ICGON, IDIBAPS, University of Barcelona, Centre for Biomedical Research on Rare Diseases (CIBER-ER), Barcelona, Spain. Electronic address:

Intrauterine growth restriction is one of the most common obstetric conditions, affecting 7-10% of fetuses. Affected fetuses are actually exposed in utero to an adverse environment during the highly critical time of development and may face life-long health consequences such as increased cardiovascular risk in adulthood. Already in utero, fetuses affected by growth restriction show remodeled hearts with signs of systolic and diastolic dysfunction. Read More

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http://dx.doi.org/10.1016/j.earlhumdev.2018.08.013DOI Listing
November 2018

The efficacy of inhaled nitric oxide treatment in premature infants with acute pulmonary hypertension.

Early Hum Dev 2018 Dec 8;127:1-5. Epub 2018 Sep 8.

Imperial College Healthcare NHS Trust, Neonatal Unit, London, UK.

Background: Although inhaled nitric oxide (iNO) therapy in term infants with pulmonary hypertension (PHT) has demonstrated definite benefit, the use of iNO in preterm infants remains inconclusive.

Aims: To evaluate the impact of iNO treatment in premature infants with acute PHT.

Study Design: Retrospective cohort. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03783782183042
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http://dx.doi.org/10.1016/j.earlhumdev.2018.09.004DOI Listing
December 2018
8 Reads