181,002 results match your criteria Ear and Hearing [Journal]


Cellular responses to thermoresponsive stiffness memory elastomer nanohybrid scaffolds by 3D-TIPS.

Acta Biomater 2018 Dec 14. Epub 2018 Dec 14.

Centre for Biomaterials in Surgical Reconstruction and Regeneration, Division of Surgery & Interventional Science, University College London, London, NW3 2PF, United Kingdom. Electronic address:

Increasing evidence suggests the contribution of the dynamic mechanical properties of the extracellular matrix (ECM) to regulate tissue remodeling and regeneration. Following our recent study on a family of thermoresponsive 'stiffness memory' elastomeric nanohybrid scaffolds manufactured via an indirect 3D printing guided thermo-induced phase separation process (3D-TIPS), this work reports in vitro and in vivo cellular responses towards these scaffolds with different initial stiffness and hierarchical interconnected porous structure. The viability of mouse embryonic dermal fibroblasts in vitro and the tissue responses during the stiffness softening of the scaffolds subcutaneously implanted in rats for three months were evaluated by immunohistochemistry and histology. Read More

View Article
December 2018

CUTICULAR DRUSEN: Risk of Geographic Atrophy and Macular Neovascularization.

Retina 2018 Dec 14. Epub 2018 Dec 14.

LuEsther T. Mertz Retinal Research Center, Manhattan Eye, Ear, and Throat Hospital, New York, New York.

Purpose: Cuticular drusen (CD) have been associated with manifestations of age-related macular degeneration such as atrophy and neovascularization in the macula. In this study, eyes with CD were followed and investigated for the estimated 5-year risk of progression to sequelae of age-related macular degeneration such as geographic atrophy (GA) and macular neovascularization (MNV).

Methods: A consecutive series of patients with CD were followed for the development of GA and MNV. Read More

View Article
December 2018
1 Read

Masking Release for Speech in Modulated Maskers: Electrophysiological and Behavioral Measures.

Ear Hear 2018 Dec 14. Epub 2018 Dec 14.

Department of Otolaryngology-Head & Neck Surgery.

Objectives: The purpose of this study was to obtain an electrophysiological analog of masking release using speech-evoked cortical potentials in steady and modulated maskers and to relate this masking release to behavioral measures for the same stimuli. The hypothesis was that the evoked potentials can be tracked to a lower stimulus level in a modulated masker than in a steady masker and that the magnitude of this electrophysiological masking release is of the same order as that of the behavioral masking release for the same stimuli.

Design: Cortical potentials evoked by an 80-ms /ba/ stimulus were measured in two steady maskers (30 and 65 dB SPL), and in a masker that modulated between these two levels at a rate of 25 Hz. Read More

View Article
December 2018

A Laboratory Evaluation of Contextual Factors Affecting Ratings of Speech in Noise: Implications for Ecological Momentary Assessment.

Ear Hear 2018 Dec 14. Epub 2018 Dec 14.

School of Audiology & Speech Sciences, University of British Columbia, Vancouver, British Columbia, Canada.

Objectives: As hearing aid outcome measures move from retrospective to momentary assessments, it is important to understand how contextual factors influence subjective ratings. Under laboratory-controlled conditions, we examined whether subjective ratings changed as a function of acoustics, response timing, and task variables.

Design: Eighteen adults (age 21 to 85 years; M = 51. Read More

View Article
December 2018

WHO World Hearing Forum: Guest Editorial: Ear and Hearing Care: A Global Public Health Priority.

Authors:
Sharon G Curhan

Ear Hear 2018 Dec 14. Epub 2018 Dec 14.

Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA; and Harvard Medical School, Boston, Massachusetts, USA.

View Article
December 2018

Pneumolabyrinth and Recurrent Paroxysmal Positional Vertigo After Traumatic Stapes Fracture.

Ann Otol Rhinol Laryngol 2018 Dec 17:3489418819553. Epub 2018 Dec 17.

3 Institute of Otolaryngology, Department of Neurosciences, Padova University, Padova, Italy.

Objectives:: The development of pneumolabyrinth without previous head trauma is a rare event; the associated symptoms may be nonspecific, and they can simulate various cochleo-vestibular pathological entities. The aim of the present study is to describe one of these rare occurrences, characterized by a peculiar onset.

Methods:: We report a case of stapes fracture secondary to ear pick penetration into the middle ear with a pneumolabyrinth that caused a recurrent paroxysmal positional vertigo (PPV) mimicking a canalolithiasis. Read More

View Article
December 2018

Prolactin-induced protein (PIP)-characterization and role in breast cancer progression.

Am J Cancer Res 2018 1;8(11):2150-2164. Epub 2018 Nov 1.

Department of Human Morphology, Division of Histology and Embryology, Wroclaw Medical University Wroclaw, Poland.

Prolactin-induced protein (PIP) is a small secreted glycoprotein carrying several N-linked carbohydrate chains. The expression of PIP is generally restricted to cells with apocrine properties. It was found in apocrine glands of the axilla, vulva, eyelid, ear canal, and seminal vesicle. Read More

View Article
November 2018

The orphan nuclear receptor EAR-2 (NR2F6) inhibits hematopoietic cell differentiation and induces myeloid dysplasia in vivo.

Biomark Res 2018 7;6:36. Epub 2018 Dec 7.

3Department of Medical Biophysics, University of Toronto, Sunnybrook Research Institute, Toronto, ON M4N 3M5 Canada.

Background: In patients with myelodysplastic syndrome (MDS), bone marrow cells have an increased predisposition to apoptosis, yet MDS cells outcompete normal bone marrow (BM)-- suggesting that factors regulating growth potential may be important in MDS. We previously identified v-Erb A related-2 (EAR-2, NR2F6) as a gene involved in control of growth ability.

Methods: Bone marrow obtained from C57BL/6 mice was transfected with a retrovirus containing EAR-2-IRES-GFP. Read More

View Article
December 2018

Segmental Maternal UPD of Chromosome 7q in a Patient With Pendred and Silver Russell Syndromes-Like Features.

Front Genet 2018 30;9:600. Epub 2018 Nov 30.

Division of Endocrine and Metabolic Diseases, Laboratory of Endocrine and Metabolic Research, IRCCS Istituto Auxologico Italiano, Milan, Italy.

Pendred syndrome (PS) is an autosomal recessive disorder due to mutations in the gene (chr7q22. 3) and characterized by sensorineural hearing loss and variable thyroid phenotype. Silver-Russell syndrome (SRS) is a heterogeneous imprinting disorder including severe intrauterine and postnatal growth retardation, and dysmorphic features. Read More

View Article
November 2018

PlantEAR: Functional Analysis Platform for Plant EAR Motif-Containing Proteins.

Front Genet 2018 30;9:590. Epub 2018 Nov 30.

State Key Laboratory of Plant Physiology and Biochemistry, College of Biological Sciences, China Agricultural University, Beijing, China.

The Ethylene-responsive element binding factor-associated Amphiphilic Repression (EAR) motifs, which were initially identified in members of the ethylene response factor (ERF) family, are transcriptional repression motifs in plants and are defined by the consensus sequence patterns of either LxLxL or DLNxxP. EAR motif-containing proteins can function as transcription repressors, thus interacting with co-repressors, such as TOPLESS and AtSAP18, affecting the structure of chromatin by histone modifications and thereby repressing gene transcription. EAR motif-containing proteins are highly conserved across diverse plant species and play important roles in hormone signal transduction, stress responses and development, but they have not been identified in most plants. Read More

View Article
November 2018

Corrigendum: Adenoviromics: Mining the Human Adenovirus Species D Genome.

Front Microbiol 2018 4;9:3005. Epub 2018 Dec 4.

Howe Laboratory, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA, United States.

[This corrects the article DOI: 10.3389/fmicb.2018. Read More

View Article
December 2018

Prevalence of hearing impairment and associated factors in school-aged children and adolescents: a systematic review.

Braz J Otorhinolaryngol 2018 Dec 1. Epub 2018 Dec 1.

Universidade Federal do Rio Grande do Norte (UFRN), Faculdade de Ciências da Saúde de Trairi (FACISA), Santa Cruz, RN, Brazil.

Introduction: Hearing impairment is one of the communication disorders of the 21st century, constituting a public health issue as it affects communication, academic success, and life quality of students. Most cases of hearing loss before 15 years of age are avoidable, and early detection can help prevent academic delays and minimize other consequences.

Objective: This study researched scientific literature for the prevalence of hearing impairment in school-aged children and adolescents, with its associated factors. Read More

View Article
December 2018

Who is pirating medical literature? A bibliometric review of 28 million Sci-Hub downloads.

Lancet Glob Health 2019 Jan;7(1):e30-e31

Harvard Medical School Program in Global Surgery and Social Change, Boston, MA 02115, USA; Massachusetts Eye and Ear Infirmary, Boston, MA, USA.

View Article
January 2019

Hazardous noise exposure from noisy toys may increase after purchase and removal from packaging: A call for advocacy.

Int J Pediatr Otorhinolaryngol 2019 Jan 22;116:84-87. Epub 2018 Oct 22.

Department of Otolaryngology, University of Minnesota School of Medicine, 516 Delaware St. SE, Suite 8-240, Minneapolis, MN, 55455, USA. Electronic address:

Objective: Previous studies identified hazardous noise levels from packaged toys. Sound levels may increase when packaging is removed and therefore, complicate the ability to accurately assess noise levels before purchase. The goal of this study was to evaluate how packaging affects the decibel (dB) level of toys by: 1) Assessing dB level of toys with and without packaging. Read More

View Article
January 2019

Findings from aetiological investigation of Auditory Neuropathy Spectrum Disorder in children referred to cochlear implant programs.

Int J Pediatr Otorhinolaryngol 2019 Jan 11;116:79-83. Epub 2018 Oct 11.

Cochlear Implant Department, Great Ormond Street Hospital, London, United Kingdom. Electronic address:

Objectives: Auditory neuropathy spectrum disorder (ANSD) is an audiological diagnosis characterised by hearing dysfunction in the presence of intact outer hair cell function in the cochlea. ANSD is thought to account for 7-10% of all childhood permanent hearing impairment, and can result from a range of pathological processes. This paper describes the rationale, methods and findings from the aetiological investigation of ANSD. Read More

View Article
January 2019

The diagnostic role of triple endoscopy in pediatric patients with chronic cough.

Int J Pediatr Otorhinolaryngol 2019 Jan 13;116:58-61. Epub 2018 Oct 13.

Pediatric Department Massachusetts Eye and Ear Infirmary, Airway and Swallowing Center Massachusetts Eye and Ear Infirmary, United States.

Objective/hypothesis: Multi-disciplinary aero-digestive centers provide high quality health care through improved outcomes and treatment costs over separate sub specialty clinics. These outcomes are often the result of a common investigative tool known as triple endoscopy: a rigid bronchoscopy performed by an otolaryngologist, flexible bronchoscopy and lavage obtained by a pulmonologist, and an endoscopy with guided biopsies performed by a gastroenterologist. Combining such procedures into one 'triple endoscopy' allows for diagnoses which otherwise might have been missed with just one procedure. Read More

View Article
January 2019

Management of velopharyngeal dysfunction in patients with 22q11.2 deletion syndrome: A survey of practice patterns.

Int J Pediatr Otorhinolaryngol 2019 Jan 12;116:43-48. Epub 2018 Oct 12.

The Children's Hospital of Philadelphia, 3400 Civic Center Boulevard, Philadelphia, PA, 19104, USA.

Objective: To determine demographics and practice patterns of surgeons treating velopharyngeal dysfunction (VPD) in patients with 22q11.2 deletion syndrome (22q11.2DS). Read More

View Article
January 2019

Treatment of objective tinnitus with transpalatal Botox injection in a pediatric patient with middle ear myoclonus: A case report.

Int J Pediatr Otorhinolaryngol 2019 Jan 25;116:22-24. Epub 2018 Sep 25.

Department of Otolaryngology Head and Neck Surgery, Baylor College of Medicine/Texas Children's Hospital, Houston, TX, USA. Electronic address:

We describe a case of bilateral middle ear myoclonus (MEM) that was treated with trans-palatal Botox injection after failing surgery to section the tensor tympani and stapedial tendons. MEM is a rare disorder resulting from rhythmic contraction of middle ear muscles. An 8-year old girl presented with audible clicking tinnitus, and resultant inability to focus in school. Read More

View Article
January 2019

Characteristics of children with refractory acute otitis media treated at the pediatric emergency department.

Int J Pediatr Otorhinolaryngol 2019 Jan 31;116:173-176. Epub 2018 Oct 31.

Department of Pediatric Otolaryngology - Head and Neck Surgery, Université de Montréal, Centre Hospitalier Universitaire Sainte-Justine, 3175 Côte Sainte-Catherine, Montréal, Québec, H3T 1C5, Canada.

Introduction: Refractory acute otitis media (rAOM) is defined as the persistence of signs and symptoms of AOM for more than 48 to 72 hours after the initiation of antibiotic treatment. These patients are often referred to the pediatric emergency department (PED). We sought to study rAOM cases referred to our PED, and to evaluate their clinical characteristics and response to our local management guidelines. Read More

View Article
January 2019

Prevalence and etiology of sensorineural hearing loss in children with down syndrome: A cross-sectional study.

Int J Pediatr Otorhinolaryngol 2019 Jan 3;116:168-172. Epub 2018 Nov 3.

Department of Otorhinolaryngology, Head and Neck Surgery, Antwerp University Hospital, Belgium. Electronic address:

Background: The prevalence and causes of sensorineural hearing loss (SNHL) in children with Down syndrome (DS) are poorly delineated.

Objective: To describe the prevalence, severity, laterality and underlying etiology of SNHL in a cohort of children with DS.

Methods: A cross-sectional study was performed among all children with DS followed at the multidisciplinary Downteam of the Antwerp University Hospital. Read More

View Article
January 2019

Short-term swallowing outcomes following type 1 laryngeal cleft injection.

Int J Pediatr Otorhinolaryngol 2019 Jan 1;116:159-163. Epub 2018 Nov 1.

Massachusetts Eye and Ear, Department of Otolaryngology, Boston, MA, USA. Electronic address:

Introduction: Interarytenoid injection augmentation at the time of initial diagnostic endoscopy for aspiration and dysphagia may result in near-immediate improvement in swallowing function, potentially obviating the need for future formal endoscopic repair of type 1 laryngeal cleft. Interarytenoid injection augmentation may also address physiologic aspiration. Early treatment of type 1 laryngeal cleft may allow for expedited liberalization of feedings. Read More

View Article
January 2019

Genotyping and audiological characteristics of infants with a single-allele SLC26A4 mutation.

Int J Pediatr Otorhinolaryngol 2019 Jan 1;116:153-158. Epub 2018 Nov 1.

Beijing Tongren Hospital, Capital Medical University, Beijing, China; Beijing Institute of Otolaryngology, Beijing, China; Key Laboratory of Otolaryngology, Head and Neck Surgery, Ministry of Education, Beijing, China.

Objectives: To identify second-allele variant in infants with a known single-allele mutation of the SLC26A4 gene and to determine the frequency of their occurrence; and to investigate the clinical audiological characteristics of infants with bi-allelic mutations in SLC26A4.

Methods: The study subjects were 371 patients with a single-allele SLC26A4 mutation detected by neonatal deafness gene screening (4 genes and 9 pathogenic variants) who were treated at the otology outpatient department of Beijing Tongren Hospital. The exonic and flanking splice site regions of the SLC26A4 gene were sequenced for all patients. Read More

View Article
January 2019

Human papillomavirus types causing recurrent respiratory papillomatosis in Zimbabwe.

Int J Pediatr Otorhinolaryngol 2019 Jan 26;116:147-152. Epub 2018 Oct 26.

Harare Eye, Ear, Nose and Throat Institute, Milton Park, Harare, Zimbabwe; Department of Surgery, Faculty of Medicine, University of Zimbabwe, Harare, Zimbabwe.

Objective: Recurrent respiratory papillomatosis (RRP) caused by human papillomavirus (HPV) is preventable through vaccination. This study was motivated by the recent thrust of the Zimbabwean government to reduce incidence of HPV related cervical cancer in Zimbabwe through vaccination against HPV. We therefore set out to type HPV genotypes causing RRP in Zimbabwe. Read More

View Article
January 2019
1 Read

Parent perspectives on multidisciplinary pediatric hearing healthcare.

Int J Pediatr Otorhinolaryngol 2019 Jan 31;116:141-146. Epub 2018 Oct 31.

The Ohio State Wexner Medical Center, College of Medicine, Department of Otolaryngology - Head & Neck Surgery, OSU Eye and Ear Institute, 915 Olentangy River Road, Columbus, OH, 43212, USA; Nationwide Children's Hospital- Pediatric Otology & Hearing Program, 700 Children's Drive, Suite 2A, Columbus, OH, 43205, USA.

Introduction: Family-centered healthcare demands that families provide input regarding the care of their children. Very little is known, however, about how families perceive their experience in different types of multidisciplinary team models, and specifically, in the multidisciplinary setting currently utilized in many pediatric hearing clinics.

Methods: Quantitative and qualitative parent survey responses were collected and analyzed in a tertiary care pediatric medical center after a one-day multidisciplinary assessment clinical appointment. Read More

View Article
January 2019

Speech development in young children with Mondini dysplasia who had undergone cochlear implantation.

Int J Pediatr Otorhinolaryngol 2019 Jan 12;116:118-124. Epub 2018 Oct 12.

Department of Otolaryngology, Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, And Beijing Institute of Otolaryngology, Beijing, 100005, China. Electronic address:

Objective: The purpose of this study was to investigate the development of speech skills in young children with Mondini dysplasia and age-matched deaf children with radiologically normal inner ears over a period of 5 years after cochlear implantation (CI).

Methods: In total, 700 congenitally severely to profoundly deaf children (281 girls and 419 boys) participated in this study. All of the participants had undergone unilateral CI surgery before 36 months of age. Read More

View Article
January 2019

Effects of socioeconomic status on children with hearing loss.

Int J Pediatr Otorhinolaryngol 2019 Jan 23;116:114-117. Epub 2018 Oct 23.

Cleveland Clinic, Head and Neck Institute, 9500 Euclid Avenue, Cleveland, OH, 44995, USA. Electronic address:

Objective: Health care disparities are noted between different socioeconomic groups; it is crucial to recognize and correct disparities, if present, that extend to children with hearing loss. The objective of the study is to evaluate the effect of socioeconomic status (SES) on access to hearing rehabilitation and speech and language therapy and outcomes in children with hearing loss.

Methods: Retrospective Chart Review of children diagnosed with hearing loss at 3 tertiary care academic centers from 2010 to 2012. Read More

View Article
January 2019

Is transcanal tympanoplasty an appropriate surgical treatment for congenital middle ear cholesteatoma with ossicular involvement?

Int J Pediatr Otorhinolaryngol 2019 Jan 23;116:102-106. Epub 2018 Oct 23.

Department of Otolaryngology, Ajou University School of Medicine, Suwon, Republic of Korea. Electronic address:

Objectives: The aims of this study are to analyze the clinical characteristics of congenital middle ear cholesteatoma (CMC), to evaluate the treatment results according to the types of surgical approach, and to suggest the appropriate surgical treatment option in each stage.

Methods: One hundred fifteen children (≤15 years old) with surgically confirmed CMC, who underwent surgery at a tertiary hospital during 1994-2012 and were followed up more than 2 years, were enrolled in this study. CMC was classified into four stages by the staging system proposed by Potsic. Read More

View Article
January 2019

Psychobiological response to an anger induction task in schizophrenia: The key role of anxiety.

Psychiatry Res 2018 Dec 7;271:541-547. Epub 2018 Dec 7.

Unitat de Psiquiatria i Psicologia Mèdica, Facultat de Medicina, Universitat de València, Avda. Blasco Ibáñez 15, València E. 46010, Spain; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM); Hospital Clínico Universitario de Valencia . Instituto de Investigación Sanitaria (INCLIVA).

In this study an anger induction laboratory task was applied to men with schizophrenia, and resulted in significant changes in different psychophysiological parameters that were measured in a pre-post design. We observed a significantly greater self-reported anger mood and negative affection, lower self-reported positive affection, an increase in cardiovascular reactivity (with blood pressure in deeper affection compared to controls), higher salivary testosterone levels, lower salivary cortisol levels, and an increase in right ear items reported in dichotic listening. Furthermore, clinical risk factors related to anger in our patients were analyzed by Stepwise Regression analyses. Read More

View Article
December 2018

Using a deep learning algorithm and integrated gradients explanation to assist grading for diabetic retinopathy.

Ophthalmology 2018 Nov 28. Epub 2018 Nov 28.

Google Research, Google Inc, Mountain View, CA, USA.

Objective: To understand the impact of deep learning diabetic retinopathy (DR) algorithms on physician readers in computer-assisted settings.

Design: Evaluation of diagnostic technology PARTICIPANTS: 1,796 retinal fundus images from 1,612 diabetic patients.

Methods: 10 ophthalmologists (5 general ophthalmologists, 4 retina specialists, 1 retina fellow) read images for DR severity based on the International Clinical Diabetic Retinopathy disease severity scale in one of 3 conditions: Unassisted, Grades Only, or Grades + Heatmap. Read More

View Article
November 2018
7 Reads

Age-related changes in neural coding of envelope cues: peripheral declines and central compensation.

Neuroscience 2018 Dec 13. Epub 2018 Dec 13.

Department of Otolaryngology, Harvard Medical School, and Eaton-Peabody Laboratories, Massachusetts Eye and Ear Infirmary, Boston, MA, 02114, USA.

Aging listeners often experience difficulties in perceiving temporally complex acoustic cues in noisy environments. These difficulties likely have neurophysiological contributors from various levels of auditory processing. Cochlear synapses between inner hair cells and auditory nerve fibers exhibit a progressive decline with age which is not reflected in the threshold audiogram. Read More

View Article
December 2018

Molecular characterization and antimicrobial susceptibility of Staphylococcus aureus isolated from children with acute otitis media in Liuzhou, China.

BMC Pediatr 2018 Dec 15;18(1):388. Epub 2018 Dec 15.

Children's Hospital of Michigan, Detroit, MI, USA.

Background: There have been few studies focused on the prevalence, bacterial etiology, antibiotic resistance, and genetic background of Staphylococcus aureus (S. aureus) in children with acute otitis media (AOM) in China.

Methods: A retrospective study was conducted in Liuzhou Maternity and Child Healthcare Hospital. Read More

View Article
December 2018

Analgesic and anti-edemic properties of etifoxine in models of inflammatory sensitization.

Eur J Pharmacol 2018 Dec 12. Epub 2018 Dec 12.

Centre National de la Recherche Scientifique and University of Strasbourg, Institut des Neurosciences Cellulaires et Intégratives, 67000 Strasbourg, France. Electronic address:

Inflammatory processes are critical promoting factors of chronic pain states, mostly by inducing peripheral and central sensitization of the nociceptive system. These processes are associated with a massive increase in glutamatergic transmission, sometimes facilitated by spinal disinhibition. In this study, we used etifoxine, a non-benzodiazepine anxiolytic known to amplify inhibition mediated by gamma-aminobutyric acid type A (GABA) receptors in pain processing regions, either directly (through allosteric modulation) or indirectly (through the synthesis of endogenous neurosteroids). Read More

View Article
December 2018
1 Read

The Impact of Prefilled Syringes on Endophthalmitis following Intravitreal Injection of Ranibizumab.

Am J Ophthalmol 2018 Dec 12. Epub 2018 Dec 12.

Mid Atlantic Retina, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, PA. Electronic address:

Purpose: To compare the rates of infectious endophthalmitis following intravitreal injection of ranibizumab using prefilled syringes vs. conventional preparation.

Design: Multicenter, retrospective, cohort study METHODS: All eyes receiving intravitreal injection of 0. Read More

View Article
December 2018

Apigetrin treatment attenuates LPS-induced acute otitis media though suppressing inflammation and oxidative stress.

Biomed Pharmacother 2019 Jan 26;109:1978-1987. Epub 2018 Nov 26.

Clinical Laboratory, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450000, China.

The natural course of otitis media in children is acute and self-limiting. Nevertheless, about 10-20% children could experience recurrent or persistent otitis media. Thus, finding effective candidate to prevent acute otitis media is urgently required. Read More

View Article
January 2019
1 Read

A CCR4 antagonist ameliorates atopic dermatitis-like skin lesions induced by dibutyl phthalate and a hydrogel patch containing ovalbumin.

Biomed Pharmacother 2019 Jan 13;109:1437-1444. Epub 2018 Nov 13.

Division of Chemotherapy, Kindai University, Faculty of Pharmacy, Kowakae 3-4-1, Higashi-Osaka, Osaka 577-8502, Japan. Electronic address:

CCR4 is a chemokine receptor highly expressed by Th2 cells, and regarded as a potential therapeutic target for atopic dermatitis (AD). CCL17 and CCL22 are the CCR4 ligands, and thymic stromal lymphopoietin (TSLP) is shown to promote the expression of CCL17 and CCL22 by dendritic cells. Here, by using dibutyl phthalate (DBP), a TSLP inducer, and a hydrogel patch as a transcutaneous delivery device for ovalbumin, we developed a novel murine AD model and investigated the effect of Compound 22, a CCR4 antagonist. Read More

View Article
January 2019
1 Read

Risk Factors for Severe Dry Eye Disease: Crowdsourced Research Using DryEyeRhythm.

Ophthalmology 2018 Dec 11. Epub 2018 Dec 11.

Juntendo University Faculty of Medicine, Department of Ophthalmology, Tokyo Japan.

This large-scale crowdsourced study using the iPhone application DryEyeRhythm identified the risk factors for severe dry eye disease-type symptoms, which included female sex, collagen disease, hay fever, depression, current contact-lens use, extended screen time, and smoking. Read More

View Article
December 2018
1 Read

The Analysis of Computed Tomography of Paranasal Sinuses in Nasal Septal Deviation.

Authors:
Demet Yazici

J Craniofac Surg 2018 Dec 13. Epub 2018 Dec 13.

Adana Numune Training and Research Hospital, Ear Nose and Throat Department, Adana, Turkey.

Objectives: Anatomic variations of paranasal sinuses are frequent among population that should be analyzed and interpreted accurately. The purpose of this study is to analyze anatomical variants and their relationships of paranasal sinuses in patients with nasal septal deviation undergoing septoplasty.

Methods: A total number of 150 patients (74 males, 76 females) with nasal septal deviation undergoing septal surgery were included in this retrospective study. Read More

View Article
December 2018

[Endoscopic keel placementto treat and prevent-bilateral vocal cord adhension].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Dec;32(23):1821-1825

Department of Otorhinolaryngology Head and Neck Surgery, Eye Ear Nose Throat Hospital of Fudan University, Shanghai, 200031, China.

To investigate the effectiveness of endoscopic keel placement for the prevention and treatment of bilateral vocal cord adhesion. There are 47 cases with bilateral vocal cord lesions and 38 cases with laryngeal adhesion in this study. Bilateral vocal cord lesions were removed and laryngeal adhesion was cut and divided. Read More

View Article
December 2018
1 Read

[MicroRNA and sensorineural hearing loss].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Oct;32(19):1523-1526

Hearing loss caused by disorders throughout the cochlea or auditory pathway called sensorineural hearing loss. The etiology of sensorineural deafness is complex and diverse, and the sensory epithelial cell damage of the inner ear spiral is the main pathological change. MicroRNAs play a role in the regulation of gene expression by inhibiting or degrading the mRNA of target genes. Read More

View Article
October 2018

[The clinical characteristics of pediatric external auditory canal keratosis obturans].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Oct;32(19):1502-1503

Department of Otolaryngology Head and Neck Surgery, Children's Hospital of Soochow University, Suzhou, 215003, China.

To analyze the clinical characteristics of pediatric external auditory canalkeratosis obturans(KO). Retrospective analyze the clinical data of twenty-three patients were diagnosed with external auditory canal cholesteatoma(EACC). Their chief complaint, the course of the disease, clinical characteristics,CT manifestations,surgical procedure and prognosis were retrospectively analyzed. Read More

View Article
October 2018

[Clinical application of seven-item Eustachian Tube Dysfunction Questionnaire].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Oct;32(19):1483-1486

Department of Otorhinolaryngology Head and Neck Surgery, Shaanxi Provincial People's Hospital.

To investigate the clinical value of the seven-item Eustachian Tube Dysfunction Questionnaire(ETDQ-7) in evaluating Eustachian tube dysfunction before and after treatment. A retrospective analysis of 50 patients with Eustachian tube dysfunction diagnosed. All the patients were given chymotrypsin 4 000 IU and dexamethasone injection 5 mg by blowing through the Eustachian tube under nasal endoscopic guidance once daily for 3-6 consecutive days. Read More

View Article
October 2018
1 Read

[The study for the characteristics of secondary acquired cholesteatoma].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Sep;32(18):1383-1386;1390

Department of Otolaryngology Head and Neck Surgery, the Air Force Military Medical University, Xijing Hospital, Xi'an, 710032, China.

Retrospctive analysed the Characteristics and outcomes of surgical treatment of 18 patients who were diagnosed as secondary acquired cholesteatoma (SAC).Patients with SAC accepted operations were enrolled in this study. Then the factors such as sex, age, cource of history, otorrhea before operation, the size of perforation of tympanic membrane, entry site of epithelium, extension direction, ossicular destruction, tympanosclerosis, tympanum tympani tendon involvement, stage of cholesteatoma(JOS, 2015, Japan),degree of gasification of mastoid(JOS,2015,Japan),air conductive threshold, bone conductive threshold, air-bone gap, the healing of tympanic membrane and the auditory improvement were analyzed. Read More

View Article
September 2018

[Clinical treatment of congenital middle ear cholesteatoma in children].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Jul;32(14):1097-1101

Children's National Medical Center, Department of Otolaryngology, Head and Neck Surgery, Beijing Children's Hospital, Capital Medical University, Beijing Key Laboratory for Pediatric Diseases of Otolaryngology, Head and Neck Surgery, Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, Beijing,100045, China.

To summarize the clinical characteristics and clinical treatment of congenital cholesteatoma (CC) of the middle ear in children, provide early diagnosis methods and explore standardized diagnosis and treatment plan.A retrospective chart review of 94 patients with a diagnosis of middle ear cholesteatoma, in Beijing Children's Hospital, between 2009 and 2015 was carried on. 14 patients with CC were identified using the criteria proposed by Levenson, and were divided into two groups according to the course of disease. Read More

View Article

[Analysis of features of ocular tilt reaction for patients with vestibular neuritis].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Jul;32(14):1091-1094

Department of Ophthalmology, Guangxi Zhuang Autonomous Region People's Hospital.

To analyze the clinical characteristics of ocular tilt reaction in vestibular neuritis patients and discuss its value to the diagnosis of vestibular neuritis.Thirty-five patients with vestibular neuritis confirmed between January 2016 and March 2018 underwent bedside vestibular function physical examination including nystagmus, head impulse test(HIT),head shaking nystagmus(HSN), ocular tilt reaction(OTR), Romberg sign, Fukuda stepping. All patients underwent head CT scan and brain MRI scan + DWI to exclude bleeding and infarction. Read More

View Article

[The application of cartilage in middle ear surgery].

Authors:
Y X Zhao L S Yu

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Dec;32(24):1912-1916

The aim of this study is to review the application, techniques and procedures of cartilage in the middle ear surgery. Cartilage offers the advantage of higher mechanical stability in tympanoplasty, which is the most common procedure in the middle ear surgery, thus apply to much complicated situation especially for tubal dysfunction and adhesive processes. There are many variations on the shape, size, thickness and technical matters of the cartilage grafts. Read More

View Article
December 2018
1 Read

[Involvement of Th17/Treg imbalance in bacterial biofilm induced chronic rhinosinusitis].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Dec;32(24):1870-1875

Department of Otolaryngology, Affiliated Eye Ear Nose and Throat Hospital, Fudan University, Shanghai, 200031, China.

The aim of this study is to investigate the involvement of Th17/Treg imbalance in the pathogenesis of bacterial biofilm (BBF) induced chronic rhinosinusitis(CRS). CRS nasal sinus mucosa was collected, and BBF was examined by BacLight/CSLM detection. Forty CRS cases(20 BBF positive cases and 20 negative cases) and 10 controls were enrolled. Read More

View Article
December 2018
1 Read

A homozygous MITF mutation leads to familial Waardenburg syndrome type 4.

Am J Med Genet A 2018 Dec 14. Epub 2018 Dec 14.

Department of Otolaryngology - Head and Neck Surgery, The Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.

Waardenburg syndrome (WS) is a genetic disorder characterized by hearing loss and pigmentary abnormalities with variable penetrance. Though heterozygous mutations in MITF are a major cause for Waardenburg syndrome type 2 (WS2), homozygous mutations in this gene and the associated phenotype have been rarely characterized. In this study, we identified a novel p. Read More

View Article
December 2018
1 Read

FDG-PET/CT for diagnosis and follow-up of necrotizing (malignant) external otitis.

Laryngoscope 2018 Dec 14. Epub 2018 Dec 14.

Department of Otolaryngology-Head and Neck Surgery, Petach Tikva, Israel.

Objective: Imaging is important for the diagnosis and follow-up of necrotizing external otitis (NEO). The best imaging modality is controversy. To suggest 2-deoxy-2-[fluorine-18] fluoro-D-glucose-positron emission tomography/computed tomography (18F-FDG-PET/CT) as an alternative to technetium-99m and gallium-67 scans for diagnosis and assessment of response to treatment for patients with NEO. Read More

View Article
December 2018

Tetanus outbreak in a sheep flock due to ear tagging.

Vet Med Sci 2018 Dec 13. Epub 2018 Dec 13.

Department of Internal Medicine, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran.

Tetanus is an acute, often fatal, infectious neuromuscular disease in all farmed mammals caused by Clostridium tetani. The disease is sporadic but outbreaks of tetanus have been described, as a result of wound contaminated with spores of C. tetani, which sporulates to the vegetative form and produce toxins. Read More

View Article
December 2018

Association of epistaxis with atherosclerotic cardiovascular disease.

Laryngoscope 2018 Dec 13. Epub 2018 Dec 13.

Department of Otorhinolaryngology-Head and Neck Surgery, University Hospital Zurich, Zurich, Switzerland.

Objectives/hypothesis: To investigate the association between epistaxis and atherosclerotic cardiovascular disease.

Study Design: Case-control cohort study.

Methods: This study included patients from the tertiary-care ear, nose, and throat department at the University Hospital of Zurich between December 1, 2016 and June 1, 2017. Read More

View Article
December 2018