Int Forum Allergy Rhinol 2017 Dec 11. Epub 2017 Dec 11.
Department of Otolaryngology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA.
Background: No high-fidelity animal model exists to examine prospective wound healing following vascularized reconstruction of the skull base. Such a model would require the ability to study the prospective behavior of vascularized mucosal repairs of large dural and arachnoid defects within the intranasal environment. The objective of this study was to therefore develop and validate a novel, in vivo, transfrontal sheep model of cranial base repair using vascularized sinonasal mucosa. Read More