288 results match your criteria Eales Disease


Choroidal Tuberculoma Manifesting in A Patient of Eales Disease 6 Years after Initial Presentation.

Ocul Immunol Inflamm 2018 Oct 19:1-3. Epub 2018 Oct 19.

b Department of Uvea and Intraocular Inflammation , Medical and Vision Research Foundations, Sankara Nethralaya , Chennai , Tamil Nadu , India.

Purpose: To describe a case of choroidal tubercle in a patient with Eales disease after 6 years, whose initial work-ups were negative for systemic diseases.

Methods: A retrospective chart review Results: This case report describes a 39-year-old male with a 6-year history of Eales disease characterized by recurrent inflammations and vitreous hemorrhages in his both eyes. His systemic work-up at the initial presentation was normal which included a negative Mantoux test and a normal chest X-ray. Read More

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https://www.tandfonline.com/doi/full/10.1080/09273948.2018.1
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http://dx.doi.org/10.1080/09273948.2018.1536792DOI Listing
October 2018
10 Reads

Progression of Eales' disease post-partum and long-term follow-up: a case report.

J Med Case Rep 2018 Oct 17;12(1):310. Epub 2018 Oct 17.

Opticlass, Coriolan Brediceanu no. 29, Timisoara, Romania.

Background: Eales' disease is a difficult to treat idiopathic form of retinal vasculitis. We present such a case with peculiar epidemiology in which the only efficient therapeutic approach in order to maintain functional vision was repeated intravitreal dexamethasone implants (Ozurdex®). To the best of our knowledge this is the first report of this kind in the literature. Read More

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http://dx.doi.org/10.1186/s13256-018-1768-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6192282PMC
October 2018
4 Reads

Ultra-widefield angiography in the diagnosis and management of uveitis.

Taiwan J Ophthalmol 2018 Jul-Sep;8(3):159-163

Department of Ophthalmology, China Medical University Hospital, China Medical University, Taichung, Taiwan.

Purpose: The aim of this study is to evaluate the clinical use of ultra-widefield angiography (UWFA) in uveitis.

Materials And Methods: We showed the UWFA and traditional 55° fluorescein angiography (FA) of four cases with Eales' disease, idiopathic retinal vasculitis, aneurysms, and neuroretinitis syndrome, Behçet's disease, and idiopathic panuveitis in a tertiary medical center. Comparison of UWFA with traditional 55°FA in the diagnosis and management of uveitis and review of the literature is also presented. Read More

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http://www.e-tjo.org/text.asp?2018/8/3/159/240731
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http://dx.doi.org/10.4103/tjo.tjo_115_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6169334PMC
October 2018
6 Reads

Pediatric Eales Disease: An Indian Tertiary Eye Center Experience.

J Pediatr Ophthalmol Strabismus 2018 Jul 1;55(4):270-274. Epub 2018 May 1.

Purpose: To report the clinical profiles, etiologies, treatment modalities, and outcomes for Eales disease in patients younger than age 16 years in India.

Methods: Retrospective review of medical records of patients with Eales disease who had a minimum 5-year follow-up period.

Results: A total of 25 eyes of 13 patients were included. Read More

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http://dx.doi.org/10.3928/01913913-20180213-01DOI Listing
July 2018
1 Read

Outcomes of transconjunctival sutureless 27-gauge vitrectomy for vitreoretinal diseases.

Int J Ophthalmol 2018 18;11(3):408-415. Epub 2018 Mar 18.

Department of Ophthalmology, Sichuan Academy of Medical Science & Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu 610072, Sichuan Province, China.

Aim: To evaluate the safety and efficacy profile of 27-gauge (27G) pars plana vitrectomy (PPV) for the treatment of various vitreoretinal diseases.

Methods: The clinical outcomes of 61 eyes (58 patients) with various vitreoretinal diseases following 27G PPV were retrospectively reviewed.

Results: Surgical indications included rhegmatogenous retinal detachment (=24), full-thickness macular hole (=12), diabetic retinopathy (=11), vitreous hemorrhage (=6), Eales disease (=4), pathological myopia-related vitreous floater (=2), and macular epiretinal membrane (=2). Read More

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http://dx.doi.org/10.18240/ijo.2018.03.10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5861230PMC
March 2018
2 Reads

Retinal vasculitis and Eales disease.

Med Clin (Barc) 2018 Oct 26;151(8):336. Epub 2018 Mar 26.

Unidad de Enfermedades Sistémicas, Servicio de Medicina Interna, Hospital San Cecilio, Granada, España.

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http://dx.doi.org/10.1016/j.medcli.2018.01.026DOI Listing
October 2018
3 Reads
1.252 Impact Factor

Eales disease in a young adult man Case report.

Rom J Ophthalmol 2017 Oct-Dec;61(4):306-309

Department of Ophthalmology, University of Medicine Cluj-Napoca, Romania.

Purpose: To report the case of a 39-year-old man with bilateral Eales disease.

Methods: The clinical, angiographic, and ultrasonographic evaluations of the patient were thoroughly and specifically carried out.

Results: The treatment consisted of pars plana vitrectomy and endolaser treatment at the time of surgery to the left eye and laser scatter retinal photocoagulation to the right eye. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5827149PMC

Spectral domain optical coherence tomography evaluation of macular changes in Eales disease.

Indian J Ophthalmol 2018 Mar;66(3):433-438

Guru Nanak Eye Centre, Maulana Azad Medical College, New Delhi, India.

Purpose: The purpose of the study was to describe macular changes in treatment-naïve eyes with Eales disease using spectral domain optical coherence tomography (SD-OCT).

Methods: A cross-sectional study was done on 79 eyes of 66 patients with Eales disease. Best-corrected visual acuity (BCVA), slit-lamp biomicroscopy (SLB), indirect ophthalmoscopy, fundus fluorescein angiography (FFA), and quantitative (central macular thickness [CMT]) and qualitative analysis on SD-OCT were performed. Read More

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http://dx.doi.org/10.4103/ijo.IJO_845_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5859602PMC
March 2018
2 Reads

Unilateral Eales' disease a case report.

Rom J Ophthalmol 2017 Apr-Jun;61(2):144-149

Department of Ophthalmology, University of Medicine and Pharmacy of Craiova, Craiova, Romania.

Eales disease is an idiopathic peripheral vascular occlusive disease characterized by inflammation, ischemia, and retinal neovascularization and is hallmarked by recurrent vitreous hemorrhages and vision loss. We present a case of a 48-year-old female with recurrent floaters and decreased vision in her right eye. The onset of symptoms was in 2007 when a diagnose of retinal vasculitis was made. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5710024PMC

A rare presentation of exudative macroaneurysms in unilateral Eales' disease.

Nepal J Ophthalmol 2017 Jan;9(18):95-98

Background: A case of exudative macroaneurysms in unilateral Eales' disease is reported. 'Eales disease' is an idiopathic bilateral occlusive periphlebitis with neovascularisation and mostly presents with vitreous hemorrhage.

Case: A 30 year old male presented with diminution of vision in left eye (6/36) for 1 month. Read More

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http://dx.doi.org/10.3126/nepjoph.v9i1.17544DOI Listing
January 2017
2 Reads

Eales Disease.

J Ayub Med Coll Abbottabad 2016 Oct-Dec;28(4):816-817

Community Medicine Department, Khyber Medical College, Peshawar.

Eales disease is an eponym after a British ophthalmologist Henry Eales. The aetiology behind Eales disease is ill-understood and stands controversial. Various systemic diseases associated with peripheral retinal revascularization and Retinal vasculitis could imitate the proliferative and inflammatory phases of Eales' disease, respectively. Read More

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November 2017
14 Reads

Long-Term Outcomes of a Large Cohort of Patients with Eales' Disease.

Ocul Immunol Inflamm 2018 27;26(6):870-876. Epub 2017 Apr 27.

d Sankara Nethralaya , Medical Research Foundation , Chennai , Tamil Nadu , India.

Purpose: To analyze the long-term visual outcomes of Eales' patients.

Methods: A retrospective review of Eales' patients diagnosed between 1985 and 1995 with >10 years follow-up done.

Results: We included 500 patients (898 eyes) with mean follow-up duration of 15. Read More

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http://dx.doi.org/10.1080/09273948.2017.1298817DOI Listing
September 2018
22 Reads

Role of high-resolution computerized tomography chest in identifying tubercular etiology in patients diagnosed as Eales' disease.

J Ophthalmic Inflamm Infect 2017 Dec 18;7(1). Epub 2017 Jan 18.

Director of Uvea and Ocular Pathology, Medical and Vision Research Foundations, Sankara Nethralaya, 18- College Road, 600006, Chennai, India.

Background: The high resolution computerized tomography of chest is an important diagnostic imaging tool to identify any pulmonary tubercular lesion. It's role in Eales' disease to identify any possible association with pulomonary tuberculosis has not been studied earlier. So, this study was conducted to assess the role of high resolution computerized tomography (HRCT) chest in identifying tuberculous etiology in Eales' disease. Read More

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http://dx.doi.org/10.1186/s12348-016-0120-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5241593PMC
December 2017
6 Reads

The 88-kDa Eales' protein in serum is a complex of haptoglobin, complement C3, and galectin-1 as identified by liquid chromatography coupled mass spectrometry.

Proteomics Clin Appl 2017 01 11;11(1-2). Epub 2016 Nov 11.

R. S. Mehta Jain Department of Biochemistry and Cell Biology, Vision Research Foundation, Sankara Nethralaya, Chennai, India.

Purpose: Eales' disease (ED), an enigmatic inflammatory disease, affects peripheral retinal veins and thereby vision in males. This study was aimed at identifying and deciphering the role of a novel 88-kDa protein reported in the serum and vitreous of patients with ED.

Experimental Design: The purified 88-kDa protein was identified by UPLC coupled ESI-QTOF-MS. Read More

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http://dx.doi.org/10.1002/prca.201600068DOI Listing
January 2017
19 Reads

Management of postvitrectomy retinal detachment due to multiple laser-induced retinal holes.

BMJ Case Rep 2016 Sep 23;2016. Epub 2016 Sep 23.

Dr Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India.

A 25-year-old man presented with retinal detachment in his right eye 20 days after pars plana vitrectomy, epiretinal membrane peeling and endolaser assisted panretinal photocoagulation performed for non-resolving vitreous haemorrhage secondary to Eales disease. Inferior retina of the right eye showed multiple (around 120) retinal holes in relation to the previous photocoagulation marks. The patient was managed with repeat vitrectomy, endolaser and silicone oil infusion. Read More

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http://dx.doi.org/10.1136/bcr-2016-216887DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5051423PMC
September 2016
5 Reads

Ultra-wide field angiography in the management of Eales disease.

Indian J Ophthalmol 2016 Jul;64(7):504-7

Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India.

Aims: This study aims to evaluate the use of ultra-wide field (UWF) angiography in patients with Eales disease (ED).

Settings And Design: Prospective observational case series in tertiary eye care center.

Subjects And Methods: This study involved 17 patients diagnosed with ED, who underwent UWF fluorescein angiography. Read More

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http://dx.doi.org/10.4103/0301-4738.190138DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5026075PMC
July 2016
4 Reads
0.930 Impact Factor

[Eales' disease].

J Fr Ophtalmol 2016 May 13;39(5):474-82. Epub 2016 May 13.

Inserm-DHOS CIC 1423, service d'ophtalmologie IV, médecine interne, laboratoire, université Pierre-et-Marie-Curie-Paris 6, centre hospitalier national des Quinze-Vingts, DHU SightRestore, 28, rue de Charenton, 75012 Paris, France.

The syndrome of recurrent vitreous hemorrhages in young men was described for the first time by Henry Eales in 1880. The association with a clinical manifestation of ocular inflammation was reported 5years later. Eales disease affects young adults who present with ischemic retinal vasculitis, with the peripheral retina most commonly affected. Read More

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http://dx.doi.org/10.1016/j.jfo.2016.03.001DOI Listing
May 2016
4 Reads

Nd:YAG laser hyaloidotomy in the management of Premacular Subhyaloid Hemorrhage.

BMC Ophthalmol 2016 Apr 18;16:41. Epub 2016 Apr 18.

Tilganga Institute of Ophthalmology, Kathmandu, Nepal.

Background: Premacular subhyaloid hemorrhage results in a sudden profound loss of vision. Among the modalities for its treatment, Nd:YAG laser hyaloidotomy is a non invasive method enabling rapid drainage of the obstructed macular area and improved vision within days. This study was aimed to evaluate the efficacy, visual outcome and complications following Nd:YAG laser hyaloidotomy for premacular subhyaloid hemorrhage. Read More

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http://dx.doi.org/10.1186/s12886-016-0218-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4835902PMC
April 2016
5 Reads

Steroid-responsive painful ophthalmoplegia: Tolosa-Hunt syndrome, Eales disease, or both?

Cephalalgia 2017 Feb 11;37(2):191-194. Epub 2016 Jul 11.

1 Neurology Department, Hospital Egas Moniz - Centro Hospitalar de Lisboa Ocidental, Lisbon, Portugal.

Introduction Tolosa-Hunt syndrome (THS) is one of the most common 'benign' causes of painful ophthalmoplegia. Diagnosis is based on clinical and imaging findings and the exclusion of other causes because there is no specific biomarker for the syndrome. Eales disease, an idiopathic inflammatory venous disease that primarily affects the eye, can also affect the central (as stroke or myelitis) and peripheral nervous system. Read More

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http://dx.doi.org/10.1177/0333102416631282DOI Listing
February 2017
11 Reads

[Eales disease and tuberculosis: A case report].

J Fr Ophtalmol 2016 Mar 29;39(3):e77-9. Epub 2016 Jan 29.

Service d'ophtalmologie, hôpital militaire d'instruction Mohamed V, Madinat Al Irfane, 10000 Rabat, Maroc.

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http://dx.doi.org/10.1016/j.jfo.2015.03.029DOI Listing
March 2016
1 Read

Localization of Human Copper Transporter 1 in the Eye and its Role in Eales Disease.

Ocul Immunol Inflamm 2016 Dec 25;24(6):678-683. Epub 2016 Jan 25.

a RS Mehta Jain Department of Biochemistry and Cell Biology , Vision Research Foundation, Sankara Nethralaya , Chennai , India.

Purpose: Copper (Cu) is an essential trace element; however excess is toxic due to the pro-oxidant activity. Increased intracellular Cu levels in vitreous and monocyte were reported in Eales disease (ED) previously. Copper transporter1 (CTR1) maintains copper homeostasis and hence, we studied the presence of CTR1 in ocular tissues and its role in ED. Read More

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http://dx.doi.org/10.3109/09273948.2015.1071404DOI Listing
December 2016
8 Reads

Man With Blurry Vision and Eye Pain.

JAMA Ophthalmol 2016 Jan;134(1):101-2

Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pennsylvania2Mid Atlantic Retina, The Retina Service of Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pennsylvania.

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http://archopht.jamanetwork.com/article.aspx?doi=10.1001/jam
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http://dx.doi.org/10.1001/jamaophthalmol.2015.2131DOI Listing
January 2016
4 Reads

Detection of Mycobacterium tuberculosis with nested polymerase chain reaction analysis in enucleated eye ball in Eales' disease.

Int Ophthalmol 2016 Jun 24;36(3):413-7. Epub 2015 Oct 24.

L&T Microbiology Research Centre, Vision Research Foundation, Chennai, India.

Nested polymerase chain reaction (nPCR) was performed on enucleated eyeball for detection of Mycobacterium tuberculosis (M. tb) genome in a patient with Eales' disease. PCR analysis in all previous studies has been done mainly using aqueous, vitreous and epiretinal membranes from these patients. Read More

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http://link.springer.com/content/pdf/10.1007%2Fs10792-015-01
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http://link.springer.com/10.1007/s10792-015-0144-9
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http://dx.doi.org/10.1007/s10792-015-0144-9DOI Listing
June 2016
6 Reads

A New Insight of Herbal Promises Against Ocular Disorders: An Occuloinformatics Approach.

Curr Top Med Chem 2016 ;16(6):634-54

AMITY Institute of Biotechnology, AMITY University Uttar Pradesh, Lucknow, U.P., India.

Ocular biology is a prominent area of research and advancement, as eyes are the most precious for us to see this beautiful world. Though we have overcome many ocular problems, but still challenges, no doubt exist in the path of the journey. Many ocular disorders still either have surgery or symptomatic drugs as a treatment. Read More

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August 2016
1 Read

Interleukin-1β Level Is Increased in Vitreous of Patients with Neovascular Age-Related Macular Degeneration (nAMD) and Polypoidal Choroidal Vasculopathy (PCV).

PLoS One 2015 15;10(5):e0125150. Epub 2015 May 15.

Department of Ophthalmology, Peking University People's Hospital, Beijing, China; Key Laboratory of Vision Loss and Restoration, Ministry of Education, Beijing, China; Beijing Key Laboratory of Diagnosis and Therapy of Retinal and Choroid Diseases, Beijing, China.

Purpose: To examine the expression of pro-interleukin-1β (pro-IL-1β) and interleukin-1β (IL-1β) in the vitreous body of patients with neovascular age-related macular degeneration(nAMD), polypoidal choroidal vasculopathy (PCV), proliferative diabetic retinopathy (PDR), retinal vein occlusion (RVO) or Eales' disease to further elucidate the role of IL-1β and inflammation in the pathogenesis of neovascular retinal disease.

Design: Prospective clinical laboratory investigation study.

Methods: All patients enrolled had vitreous hemorrhage due to nAMD, PCV, PDR, RVO or Eales' disease that required vitrectomy. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0125150PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4433218PMC
March 2016
2 Reads

Association of Mycobacterium tuberculosis in the causation of Eales' disease: an institutional experience.

Indian J Med Microbiol 2015 Feb;33 Suppl:43-5

Department of Microbiology, ? All India Institute of Medical Sciences, New Delhi, India.

Background: Eales' disease is an idiopathic retinal vasculitis characterized by retinal inflammation, ischemia, and neo-vascularisation. It frequently causes massive vitreous haemorrhage and retinal detachment leading to blindness. Although the exact etiology is unknown, this condition is considered to be a consequence of hypersensitivity reaction to tubercular protein due to previous Mycobacterium tuberculosis (M. Read More

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http://dx.doi.org/10.4103/0255-0857.148829DOI Listing
February 2015
3 Reads

Eales disease: no typical clinical presentation.

Pan Afr Med J 2014 26;17:136. Epub 2014 Feb 26.

University Mohamed V Souissi, Hôpital des Spécialités, Ophtalmologie A Department, Morocco.

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http://www.panafrican-med-journal.com/content/article/17/136
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http://dx.doi.org/10.11604/pamj.2014.17.136.4019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4218641PMC
July 2015
6 Reads

Angiogenic potential of vitreous from Proliferative Diabetic Retinopathy and Eales' Disease patients.

PLoS One 2014 13;9(10):e107551. Epub 2014 Oct 13.

Department of Immunology and Cell Biology, Aravind Medical Research Foundation, Dr.G.Venkataswamy Eye Research Institute, Madurai, India.

Purpose: Proliferative Diabetic Retinopathy (PDR) and Eales' Disease (ED) have different aetiologies although they share certain common clinical symptoms including pre-retinal neovascularization. Since there is a need to understand if the shared end-stage angiogenic pathology of PDR and ED is driven by common stimulating factors, we have studied the cytokines contained in vitreous from both patient groups and analyzed the angiogenic potential of these samples in vitro.

Material And Methods: Vitreous samples from patients with PDR (n = 13) and ED (n = 5) were quantified for various cytokines using a cytokine biochip array and sandwich ELISA. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0107551PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4195571PMC
June 2015
2 Reads

Combination of intravitreal bevacizumab and peripheral photocoagulation: an alternative treatment in eales disease.

Med Hypothesis Discov Innov Ophthalmol 2013 ;2(2):30-4

Department of Ophthalmology, Centro de Ojos Romagosa-Fundación VER, Córdoba, Argentina.

To report the efficacy of combination therapy (bevacizumab and photocoagulation) in a case of Eales Disease this study has been performed. Bevacizumab (Avastin, 1.25 mg/0. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3939753PMC
March 2014
2 Reads

Sickle cell retinopathy: diagnosis and treatment.

Arq Bras Oftalmol 2013 Oct;76(5):320-7

Hemoglobinopathies are a group of inherited disorders characterized by quantitative or qualitative malformations of hemoglobin (Hb). Some of these diseases present vaso-occlusive phenomena that are responsible for high morbidity in clinical and/or ophthalmologic terms. Diagnosis of hemoglobinopathies is performed exclusively through hemoglobin electrophoresis. Read More

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October 2013
3 Reads

Clinical features and etiology of retinal vasculitis in Northern Thailand.

Indian J Ophthalmol 2013 Dec;61(12):739-42

Department of Ophthalmology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.

Purpose: To report on the clinical features and etiology of patients with retinal vasculitis (RV).

Materials And Methods: We reviewed medical records of 47 patients (75 affected eyes) diagnosed with RV. Clinical presentations, ocular complications, associated systemic diseases, and treatment regimens were registered. Read More

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http://dx.doi.org/10.4103/0301-4738.120216DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3917393PMC
December 2013
3 Reads

Surgical outcomes of minimally invasive vitrectomy surgery in Eales' disease.

Nepal J Ophthalmol 2013 Jul-Dec;5(2):182-9

Introduction: The results of surgical outcomes of 20 gauge pars plana vitrectomy in Eales' disease are available in the scientific literature. However, all these studies have been done using the 20 gauge vitrectomy systems and most studies have been conducted in a retrospective manner.

Objective: To evaluate the outcomes and safety of 23 gauge vitrectomy in complications of Eales' disease. Read More

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http://dx.doi.org/10.3126/nepjoph.v5i2.8710DOI Listing
March 2015
4 Reads

Eales' disease with neurological complications.

Neurol India 2013 Jul-Aug;61(4):428-9

Department of Neurology, NRS Medical College and Hospital, Kolkata, West Bengal, India.

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http://dx.doi.org/10.4103/0028-3886.117593DOI Listing
February 2014
3 Reads

Increased homocysteine, homocysteine-thiolactone, protein homocysteinylation and oxidative stress in the circulation of patients with Eales' disease.

Ann Clin Biochem 2013 Jul 10;50(Pt 4):330-8. Epub 2013 Jun 10.

Department of Biochemistry and Cell Biology, Vision Research Foundation, Sankara Nethralaya, Chennai, India.

Background: Eales' disease (ED) is an idiopathic retinal vascular disorder. It presents with inflammation and neovascularization in the retina. Adult men, aged between 15 and 40 years are more susceptible than women. Read More

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http://acb.sagepub.com/content/early/2013/06/10/000456321349
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http://acb.sagepub.com/lookup/doi/10.1177/0004563213492146
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http://dx.doi.org/10.1177/0004563213492146DOI Listing
July 2013
4 Reads

Tubercular retinal vasculitis.

BMJ Case Rep 2013 Jun 3;2013. Epub 2013 Jun 3.

Department of Ophthalmology, Hospital de Egas Moniz, Lisbon, Portugal.

Intraocular tuberculosis (TB) infection can have different clinical manifestations including retinal vasculitis. It more frequently involves the veins and is associated with retina haemorrhages and neovascularisation. The diagnosis may be difficult and presumptive being based on clinical findings and evidence of systemic TB infection. Read More

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http://dx.doi.org/10.1136/bcr-2013-008924DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3702819PMC
June 2013
2 Reads

Eales' disease - current concepts in diagnosis and management.

J Ophthalmic Inflamm Infect 2013 Jan 14;3(1):11. Epub 2013 Jan 14.

Department of Uveitis and Ocular Pathology, Vision Research Foundation, Sankara Nethralaya, No, 41, College Road, Nungambakkam, Chennai, 600006, India.

Eales' disease, first described by the British ophthalmologist Henry Eales in 1880, is characterized by three overlapping stages of venous inflammation (vasculitis), occlusion, and retinal neovascularization. Diagnosis is mostly clinical and requires exclusion of other systemic or ocular conditions that could present with similar retinal features. In recent years, immunological, molecular biological, and biochemical studies have indicated the role of human leukocyte antigen, retinal autoimmunity, Mycobacterium tuberculosis genome, and free radical-mediated damage in the etiopathogenesis of this disease. Read More

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http://dx.doi.org/10.1186/1869-5760-3-11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3605068PMC
January 2013
3 Reads

Vitreous hemorrhage in children and adolescents in India.

J AAPOS 2013 Feb;17(1):64-9

Shri Bhagwan Mahavir Vitreoretinal Services, Sankara Nethralya, Tamil Nadu, India.

Purpose: To report the clinical profile, etiologies, treatment modalities, and outcomes for vitreous hemorrhage in patients <18 years of age in India.

Methods: The medical records of patients presenting with vitreous hemorrhage between January 2000 and January 2010 were retrospectively reviewed.

Results: A total of 261 eyes of 246 patients (201 males) were included. Read More

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http://dx.doi.org/10.1016/j.jaapos.2012.10.013DOI Listing
February 2013
1 Read

Profiling of human leukocyte antigens in Eales disease and tuberculosis.

Int Ophthalmol 2013 Oct 6;33(5):475-9. Epub 2013 Feb 6.

Department of Ophthalmology, The Affiliated Hospital of Zunyi Medical College, Zunyi, 563003, China,

To analyze the association between Eales disease, histocompatibility leukocyte antigen alleles (HLA-A/B, HLA-DRB/DQB) and tuberculosis infection, and to explore susceptible genes and protective genes associated with Eales disease and tuberculosis infection in a population of Han nationals from Zunyi City in Guizhou Province, China. The subjects were analyzed by a case-control study consisting of three groups--Eales disease group (47 cases), pulmonary tuberculosis group (36 cases) and normal control group (100 cases). The Eales disease group was divided into four parts. Read More

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http://dx.doi.org/10.1007/s10792-013-9718-6DOI Listing
October 2013
2 Reads

Eales' disease following hypothyroidism secondary to Hashimotos thyroiditis.

J Med Assoc Ga 2012 ;101(3):30, 41

Southwest Georgia Family Residency, Albany, USA.

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December 2012
2 Reads

Vitreopapillary and vitreomacular traction in proliferative Eales' disease.

BMJ Case Rep 2012 Oct 29;2012. Epub 2012 Oct 29.

Department of Ophthalmology, CSM Medical University (Erstwhile King George's Medical University), Lucknow, Uttar Pradesh, India.

Vitreoretinal interface alterations leading to vitreopapillary and vitreomacular traction in a 29-year case of proliferative Eales' disease is described for the first time. On fundus examination, an ellipsoid area of vitreomacular traction was noted temporal to the optic disc. A triangular-shaped infolding of the retina was observed superior to the fovea. Read More

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http://dx.doi.org/10.1136/bcr-2012-007231DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4543417PMC
October 2012
3 Reads

Quantitative polymerase chain reaction for Mycobacterium tuberculosis in so-called Eales' disease.

Ocul Immunol Inflamm 2012 Jun 9;20(3):153-7. Epub 2012 Apr 9.

Advanced Eye Centre, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

Purpose: To report mycobacterial load in the vitreous of patients labeled as having Eales' disease.

Methods: Eighty-eight patients were prospectively enrolled into 3 groups: 28 patients with so-called Eales' disease (group A); 30 positive controls with specific uveitis syndromes (group B), and 30 negative controls (group C). The undiluted vitreous humor samples were collected and subjected to real-time PCR assay for MPB64 gene of Mycobacterium tuberculosis (MTB) and load quantified. Read More

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http://dx.doi.org/10.3109/09273948.2012.658134DOI Listing
June 2012
7 Reads

[Eales disease presenting with vitreous hemorrhage].

J Fr Ophtalmol 2012 Oct 31;35(8):646-8. Epub 2012 Mar 31.

Service d'ophtalmologie, hôpital Mère-Enfant, CHU Mohammed VI, avenue Ibn-Sina-Ammerchich, BP 2360 Allal Elfassi, 40055 Marrakech, Maroc.

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http://dx.doi.org/10.1016/j.jfo.2011.09.014DOI Listing
October 2012
2 Reads

The use of a vascular endothelial growth factor inhibitor (ranibizumab) in macular edema due to eales disease.

Retin Cases Brief Rep 2012 ;6(1):122-4

From the Casey Eye Institute, Department of Ophthalmology, Oregon Health & Science University, Portland, Oregon.

Purpose: To report the results of intravitreal use of ranibizumab in a patient with macular edema due to Eales disease.

Method: This was an open-label, Phase 1, 6-month study of the safety and efficacy of intravitreally administered ranibizumab in patients with macular edema due to Eales disease. A single patient was eligible for the study during the 2 years of recruitment. Read More

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http://dx.doi.org/10.1097/ICB.0b013e31821608e8DOI Listing
November 2014
4 Reads

Protein-ligand interaction studies of retinol-binding protein 3 with herbal molecules using AutoDock for the management of Eales' disease.

J Ocul Biol Dis Infor 2012 30;5(2):40-3. Epub 2012 Dec 30.

Amity Institute of Biotechnology, Amity University Uttar Pradesh, Lucknow, India.

Eales' disease is an idiopathic retinal vasculitis of the eye. The disease is predominantly characterized by recurrent vitreous hemorrhage. Interphotoreceptor retinol-binding protein 3 plays a significant role in the etiopathogenesis of this condition. Read More

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http://dx.doi.org/10.1007/s12177-012-9098-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3572241PMC
December 2013
3 Reads

Secondary rhegmatogenous retinal detachment following intravitreal bevacizumab in patients with vitreous hemorrhage or tractional retinal detachment secondary to Eales' disease.

Graefes Arch Clin Exp Ophthalmol 2012 May 15;250(5):685-90. Epub 2011 Dec 15.

Dr Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, 110029, India.

Background: To report the occurrence of secondary rhegmatogenous retinal detachment (RRD) after intravitreal bevacizumab injection in patients with Eales' disease.

Methods: This is a retrospective, non-controlled, comparative case series. We reviewed 14 eyes of 14 patients with Eales' disease who had received pretreatment with intravitreal bevacizumab (1. Read More

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http://link.springer.com/content/pdf/10.1007/s00417-011-1890
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http://dx.doi.org/10.1007/s00417-011-1890-7DOI Listing
May 2012
7 Reads

Intravitreal bevacizumab as an adjunct to vitrectomy in advanced Eales' disease.

J Ophthalmic Inflamm Infect 2012 Jun 17;2(2):105-8. Epub 2011 Nov 17.

Maulana Azad Medical College, New Delhi, India.

Purpose: This study aimed to report the use of intravitreal bevacizumab as an adjunctive treatment in two cases of advanced Eales' disease with vitreous haemorrhage and tractional retinal detachment, prior to vitreoretinal surgery.

Method: In two patients presenting with vitreous haemorrhage, retinal neovascularisation and localised tractional retinal detachment, 1.25 mg of intravitreal bevacizumab was injected prior to vitrectomy, membrane peeling and endolaser photocoagulation of retina. Read More

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http://dx.doi.org/10.1007/s12348-011-0049-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3345052PMC
June 2012
2 Reads

[Sudden decrease in visual acuity and pulmonary infiltrates].

Enferm Infecc Microbiol Clin 2012 Mar 10;30(3):161-2. Epub 2011 Nov 10.

Servicio de Medicina Interna, Hospital Son Llàtzer, Palma de Mallorca, España.

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http://dx.doi.org/10.1016/j.eimc.2011.06.008DOI Listing
March 2012
3 Reads

Impact of interleukin-6 promoter polymorphism and serum interleukin-6 level on the acute inflammation and neovascularization stages of patients with Eales' disease.

Mol Vis 2011 1;17:2552-63. Epub 2011 Oct 1.

Department of Biochemistry, Dr. B C Roy Post Graduate Institute of Basic Medical Education and Research (IPGME&R), Kolkata, India.

Purpose: To evaluate the role of interleukin-6 (IL-6) in the inflammatory and proliferative stages of Eales' disease (ED) and to determine the influence of IL-6-174G/C polymorphism in the IL-6 and IL-6-regulated protein expression, as well as the development of ED.

Methods: One hundred and twenty-one patients diagnosed with ED, 223 matched healthy controls, and 16 control patients with macular holes were recruited from the eastern Indian population. Serum and vitreous levels of IL-6 and vascular endothelial growth factors (VEGF) were measured by enzyme-linked immunosorbent assay. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3198485PMC
February 2012
7 Reads
7 Citations
1.990 Impact Factor

Elevated tumor necrosis factor in serum is associated with increased retinal ischemia in proliferative eales' disease.

Pathobiology 2011 17;78(5):261-5. Epub 2011 Aug 17.

Department of Ophthalmology, CSM Medical University, Lucknow, India. sandeepsaxena2020@ yahoo.com

Objective: Tumor necrosis factor (TNF) was evaluated in the serum of patients with proliferative stage of Eales' disease to study its relation with the area of retinal capillary non-perfusion (ischemic retina).

Methods: Quantification of the levels of TNF was done using sandwich ELISA in 52 cases with proliferative Eales' disease and in 32 healthy controls. Seven 50° photographs of different fields of the fundus were taken on fluorescein angiography. Read More

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http://dx.doi.org/10.1159/000329589DOI Listing
January 2012
3 Reads
2 Citations
2.320 Impact Factor