310 results match your criteria Eales Disease


Optical coherence tomography angiography features of macular epiretinal neovascularization in Eales' disease: a case report.

J Ophthalmic Inflamm Infect 2022 May 6;12(1):16. Epub 2022 May 6.

Vitreoretinal Division, King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia.

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Quantile-Dependent Expressivity of Serum Interleukin-6 Concentrations as a Possible Explanation of Gene-Disease Interactions, Gene-Environment Interactions, and Pharmacogenetic Effects.

Authors:
Paul T Williams

Inflammation 2022 Jun 7;45(3):1059-1075. Epub 2022 Jan 7.

Lawrence Berkeley National Laboratory, Molecular Biophysics & Integrated Bioimaging Division, 1 Cyclotron Road, Berkeley, CA, 94720, USA.

Interleukin 6 (IL-6) is a moderately heritable pleiotropic cytokine whose elevated concentrations in coronary artery disease, peripheral arterial disease, pulmonary arterial hypertension, Eales' disease, Sjògren's syndrome, osteoarthritis, adenocarcinoma, neuroblastoma, polymyalgia rheumatica, pulmonary tuberculosis, and enterovirus 71 infection, and following coronary artery bypass graft show larger genetic effects than in unaffected low IL-6 controls. We hypothesize that genetic effects may depend upon whether average IL-6 concentrations are high or low, i.e. Read More

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Eales' disease: epidemiology, diagnostic and therapeutic concepts.

Int J Retina Vitreous 2022 Jan 4;8(1). Epub 2022 Jan 4.

Instituto Privado de Oftalmología, La Paz, Bolivia.

Background: To describe the epidemiological traits, clinical characteristics, diagnostic procedures, therapeutic interventions and evolution in a large series of patients with diagnosis of Eales' disease.

Methods: A clinical retrospective review of patients with Eales' disease, evaluated and treated between April 2009 and April 2018, with a 1-year minimum follow-up. Thirty patients (59 eyes), were included. Read More

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January 2022

Advanced Eales' Disease With Neovascular Glaucoma at First Presentation.

Cureus 2021 Sep 26;13(9):e18302. Epub 2021 Sep 26.

Ophthalmology, Dhahran Eye Specialist Hospital, Dhahran, SAU.

Eales' disease is an idiopathic vasculitis that affects the peripheral retina. It is characterized by recurrent vitreous hemorrhage as a complication of retinal neovascularization. It is more prevalent in India and affects young males. Read More

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September 2021

Histopathological, immunohistochemical and molecular biologic study of an enucleated specimen of a case of Eales' disease.

J Ophthalmic Inflamm Infect 2021 Sep 1;11(1):29. Epub 2021 Sep 1.

Uvea Department, Medical Research Foundation, Sankara Nethralaya, 18 College Road, Tamilnadu, 600006, Chennai, India.

Eales' disease is a retinal vasculitis characterized by retinal inflammation, ischemia, and neovascularization. Exact pathogenesis of this disease is yet to be found out. We present a 29-year-old male, diagnosed with Eales' disease in both eyes with persistent intraocular inflammation. Read More

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September 2021

Eales' Disease: When the Rare Sounds Frequent.

Case Rep Ophthalmol Med 2021 9;2021:1056659. Epub 2021 Aug 9.

Department of Ophthalmology, Beatriz Ângelo Hospital, Loures, Portugal.

Eales' disease is a peripheral occlusive retinal phlebitis, with an unclear pathogenesis. The classic association with hypersensitivity to protein infers that immunologic disturbance may be involved. Here, we described three cases of Eales' disease. Read More

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Reply to Comments on Manuscript "Role of Ultra-widefield Imaging in Eales' Disease: A Case Series".

Ocul Immunol Inflamm 2021 Jul 13. Epub 2021 Jul 13.

Larsen & Toubro Ocular Pathology Department, Medical Research Foundation, SankaraNethralaya, Chennai, India.

In a comment on our article ''Role of Ultra-widefield Imaging in Eales' Disease: A Case Series", the author asserts that Widefield fluorescein angiography (FA) detected significantly more number of active vasculitis as compared to Optos in our study which is not in line with our conclusion. We agree that Widefield FA is the gold standard for detecting activity in uveitic eye, and in fact, we have mentioned that 'FA was considered the gold standard for diagnosing active vasculitis and clinical examination and Optos findings were compared to FA' in our Materials and methods section. Read More

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Vitrectomy Due to Vitreous Hemorrhage and Tractional Retinal Detachment Secondary to Eales' Disease

Turk J Ophthalmol 2021 04;51(2):102-106

İstanbul Retina Institute, İstanbul, Turkey

Objectives: To investigate visual and anatomical outcomes of vitreoretinal surgeries in patients with Eales' disease.

Materials And Methods: In this retrospective study, 22 eyes of 21 patients with vitreous hemorrhage (VH) or tractional retinal detachment (TRD) secondary to Eales' disease who underwent vitreoretinal surgery between January 1997 and December 2015 and had at least 1 year of follow-up were included.

Results: The mean best corrected visual acuity (BCVA) was significantly higher at final visit (0. Read More

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Intravitreal Aflibercept as a Rescue Therapy for Retinal Neovascularization and Macular Edema due to Eales Disease.

Case Rep Ophthalmol Med 2021 11;2021:8887362. Epub 2021 Feb 11.

Department of Ophthalmology, China Medical University Hospital, China Medical University, Taichung, Taiwan.

We report the rescue effect of intravitreal aflibercept injections on retinal neovascularization and macular edema due to Eales disease. Case 1 was a 36-year-old female. Intravitreal aflibercept was administered as rescue therapy after persistent retinal neovascularization following retinal photocoagulation, periocular triamcinolone, and intravitreal ranibizumab injection. Read More

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February 2021

Papillophlebitis as an initial presentation of Eales' disease.

Oman J Ophthalmol 2020 Sep-Dec;13(3):161-163. Epub 2020 Nov 2.

Department of Uvea, Medical and Vision Research Foundations, Chennai, Tamil Nadu, India.

Eales' disease (ED), which is an idiopathic obliterative vasculitis, is a diagnosis of exclusion. The optic nerve involvement in ED is not very common. We report a case of ED in a 36-year-old male who initially presented as papillephlebitis. Read More

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November 2020

Comparison of fundus fluorescein angiography, optical coherence tomography and optical coherence tomography angiography features of macular changes in Eales disease: a case series.

J Ophthalmic Inflamm Infect 2020 Dec 14;10(1):34. Epub 2020 Dec 14.

Guru Nanak Eye Centre, Near Zakir Hussain College, Maharaja Ranjeet Singh Marg, 64 Khamba, New Delhi, Delhi, 110002, India.

Purpose: To study the macular features in Eales disease patients observed with fundus fluorescein angiography (FA), optical coherence tomography (OCT) and optical coherence tomography angiography (OCTA).

Methods: A cross-sectional study was done on treatment naïve 31 eyes (23 patients) with Eales disease. Baseline parameters such as Best-corrected visual acuity (BCVA), slit-lamp bio microscopy (SLB), indirect ophthalmoscopy, FA, spectral-domain OCT {quantitative (central macular thickness [CMT]) and qualitative analysis on SD-OCT} and OCTA were performed. Read More

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December 2020

Young Male with Paraparesis and Vision Loss- A Rare Presentation of Eales' Disease.

Ann Indian Acad Neurol 2020 Jul-Aug;23(4):563-566. Epub 2020 Jun 29.

Department of Neurology, Govind Ballabh Pant Institute of Post Graduate Medical Education and Research (GIPMER), New Delhi, India.

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Further evidence of the association of latent Mycobacterium tuberculosis in Eales' disease.

Int Ophthalmol 2021 Mar 16;41(3):901-906. Epub 2020 Nov 16.

Department of Uvea, Medical and Vision Research Foundation, Sankara Nethralaya, No. 41 (old 18), College RoadTamil Nadu, Chennai, 600006, India.

Purpose: To find out association of Eales' disease with Mycobacterium tuberculosis.

Methods: A retrospective study was done recruiting patients visiting the uvea clinic with diagnosis of Eales' disease from 2015-2019. Seventy-nine eyes of 50 patients diagnosed as Eales' disease underwent Mantoux test, QuantiFERON-TB Gold test, high resolution computed tomography (HRCT) of the chest and anterior chamber or vitreous tap for TB genome polymerase chain reaction(PCR). Read More

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Ultrasound findings in a case of Eales' disease and ocular trauma with anterior chamber cholesterolosis.

BMC Ophthalmol 2020 Oct 6;20(1):393. Epub 2020 Oct 6.

State Key Laboratory of Ophthalmology, Department of Glaucoma, Zhongshan Ophthalmic Center, Sun Yat-sen University, 7 Jinsui Road, Guangzhou, 510623, China.

Background: Anterior chamber cholesterolosis is a rare phenomenon which occurs mostly in chronically blind eyes. We present the anterior and posterior ultrasound findings in a case of anterior chamber cholesterolosis secondary to Eales' disease and ocular trauma, which may contribute to the understanding of the potential mechanism of this phenomenon.

Case Presentation: A 48-year-old man presented with "sparking" right eye, which appeared soon after the ocular trauma. Read More

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October 2020

Letter to the Editor: Reply to Manuscript "Role of Ultra-widefield Imaging in Eales' Disease: A Case Series".

Ocul Immunol Inflamm 2022 Jan 23;30(1):136. Epub 2020 Sep 23.

DR R. P. Centre for Ophthalmic Sciences, All India Institute of Medical Sciences (AIIMS), New Delhi, India.

We read with interest the article "Role of Ultra-widefield Imaging in Eales' Disease: A Case Series" by Agarwal et al. We would like to congratulate the authors for their nice work and make few observations.We noted few discrepancies between the results and conclusions. Read More

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January 2022

Role of Ultra-widefield Imaging in Eales' Disease: A Case Series.

Ocul Immunol Inflamm 2020 Nov 28;28(8):1187-1191. Epub 2020 May 28.

Larsen & Toubro Ocular Pathology Department, SankaraNethralaya , Chennai, India.

: To describe and quantify the benefit of ultra-widefield imaging in cases of Eales' disease during primary and follow-up visits. : This was a retrospective cross-sectional observational study screening case records of Eales' disease patients. Disease activity of each patient visit was assessed on clinical examination with indirect-ophthalmoscopy, ultra-widefield images (Optos) and widefield fluorescein angiography (FA) images. Read More

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November 2020

[Treatment of ocular tuberculosis-an update].

Ophthalmologe 2020 Nov;117(11):1080-1086

Berner Augenklinik am Lindenhofspital, Swiss Eye Institute, Bremgartenstr. 119, 3012, Bern, Schweiz.

Background: Tuberculous uveitis (TU) is initially usually not acute, accompanied by only slight visual disorders and affects otherwise healthy individuals so that the diagnosis is frequently primarily overlooked.

Objective: This study was carried out to provide an update of the treatment options in suspected TU.

Material And Methods: A PubMed search was undertaken using the key terms uveitis AND tuberculosis AND treatment for manuscripts published within the last decade. Read More

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November 2020

Diagnosis of Eales disease from a macular epiretinal membrane.

Arch Soc Esp Oftalmol (Engl Ed) 2019 Nov 19;94(11):556-560. Epub 2019 Jul 19.

Sección de Retina Médica, Servicio de Oftalmología, Hospital Universitario Virgen del Rocío, Sevilla, España.

Macular involvement is a common finding in patients with Eales disease. The purpose of this communication is to describe the diagnosis of Eales disease from the finding of a macular epiretinal membrane in a young patient. The case is presented of a 38-year-old man referred to this medical service unit with blurred vision developed over the past 3 months, and was associated with vitreoretinal traction and a macular epiretinal membrane. Read More

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November 2019

Wide-field angiography for diagnosis and follow-up of Eales disease: a case series.

Arq Bras Oftalmol 2019 05 20;82(4):339-344. Epub 2019 May 20.

Retina and Vitreous Research Unit, Ophthalmic Center Macula D&T, Lima, Peru.

Wide-field angiography enables assessing peripheral areas with better quality and gives greater deep focus, which improves the image periphery. Some studies have proposed the usefulness of these angiographic systems in inflammatory diseases of the retina. However, few studies have evaluated this technique in Eales disease. Read More

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Choroidal Tuberculoma Manifesting in A Patient of Eales Disease 6 Years after Initial Presentation.

Ocul Immunol Inflamm 2020 19;28(1):100-102. Epub 2018 Oct 19.

Department of Uvea and Intraocular Inflammation, Medical and Vision Research Foundations, Sankara Nethralaya, Chennai, Tamil Nadu, India.

To describe a case of choroidal tubercle in a patient with Eales disease after 6 years, whose initial work-ups were negative for systemic diseases. A retrospective chart review This case report describes a 39-year-old male with a 6-year history of Eales disease characterized by recurrent inflammations and vitreous hemorrhages in his both eyes. His systemic work-up at the initial presentation was normal which included a negative Mantoux test and a normal chest X-ray. Read More

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December 2020

Progression of Eales' disease post-partum and long-term follow-up: a case report.

J Med Case Rep 2018 Oct 17;12(1):310. Epub 2018 Oct 17.

Opticlass, Coriolan Brediceanu no. 29, Timisoara, Romania.

Background: Eales' disease is a difficult to treat idiopathic form of retinal vasculitis. We present such a case with peculiar epidemiology in which the only efficient therapeutic approach in order to maintain functional vision was repeated intravitreal dexamethasone implants (Ozurdex®). To the best of our knowledge this is the first report of this kind in the literature. Read More

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October 2018

Ultra-widefield angiography in the diagnosis and management of uveitis.

Taiwan J Ophthalmol 2018 Jul-Sep;8(3):159-163

Department of Ophthalmology, China Medical University Hospital, China Medical University, Taichung, Taiwan.

Purpose: The aim of this study is to evaluate the clinical use of ultra-widefield angiography (UWFA) in uveitis.

Materials And Methods: We showed the UWFA and traditional 55° fluorescein angiography (FA) of four cases with Eales' disease, idiopathic retinal vasculitis, aneurysms, and neuroretinitis syndrome, Behçet's disease, and idiopathic panuveitis in a tertiary medical center. Comparison of UWFA with traditional 55°FA in the diagnosis and management of uveitis and review of the literature is also presented. Read More

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October 2018

Pediatric Eales Disease: An Indian Tertiary Eye Center Experience.

J Pediatr Ophthalmol Strabismus 2018 Jul 1;55(4):270-274. Epub 2018 May 1.

Purpose: To report the clinical profiles, etiologies, treatment modalities, and outcomes for Eales disease in patients younger than age 16 years in India.

Methods: Retrospective review of medical records of patients with Eales disease who had a minimum 5-year follow-up period.

Results: A total of 25 eyes of 13 patients were included. Read More

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Ocular Involvement in Sarcoidosis.

J Rheumatol 2018 04;45(4):580

Department of Ophthalmology, SUNY Downstate Medical Center, Brooklyn, New York, USA.

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Outcomes of transconjunctival sutureless 27-gauge vitrectomy for vitreoretinal diseases.

Int J Ophthalmol 2018 18;11(3):408-415. Epub 2018 Mar 18.

Department of Ophthalmology, Sichuan Academy of Medical Science & Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu 610072, Sichuan Province, China.

Aim: To evaluate the safety and efficacy profile of 27-gauge (27G) pars plana vitrectomy (PPV) for the treatment of various vitreoretinal diseases.

Methods: The clinical outcomes of 61 eyes (58 patients) with various vitreoretinal diseases following 27G PPV were retrospectively reviewed.

Results: Surgical indications included rhegmatogenous retinal detachment (=24), full-thickness macular hole (=12), diabetic retinopathy (=11), vitreous hemorrhage (=6), Eales disease (=4), pathological myopia-related vitreous floater (=2), and macular epiretinal membrane (=2). Read More

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Retinal vasculitis and Eales disease.

Med Clin (Barc) 2018 10 26;151(8):336. Epub 2018 Mar 26.

Unidad de Enfermedades Sistémicas, Servicio de Medicina Interna, Hospital San Cecilio, Granada, España.

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October 2018

Eales disease in a young adult man Case report.

Rom J Ophthalmol 2017 Oct-Dec;61(4):306-309

Department of Ophthalmology, University of Medicine Cluj-Napoca, Romania.

Purpose: To report the case of a 39-year-old man with bilateral Eales disease.

Methods: The clinical, angiographic, and ultrasonographic evaluations of the patient were thoroughly and specifically carried out.

Results: The treatment consisted of pars plana vitrectomy and endolaser treatment at the time of surgery to the left eye and laser scatter retinal photocoagulation to the right eye. Read More

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Spectral domain optical coherence tomography evaluation of macular changes in Eales disease.

Indian J Ophthalmol 2018 Mar;66(3):433-438

Guru Nanak Eye Centre, Maulana Azad Medical College, New Delhi, India.

Purpose: The purpose of the study was to describe macular changes in treatment-naïve eyes with Eales disease using spectral domain optical coherence tomography (SD-OCT).

Methods: A cross-sectional study was done on 79 eyes of 66 patients with Eales disease. Best-corrected visual acuity (BCVA), slit-lamp biomicroscopy (SLB), indirect ophthalmoscopy, fundus fluorescein angiography (FFA), and quantitative (central macular thickness [CMT]) and qualitative analysis on SD-OCT were performed. Read More

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