321,167 results match your criteria EXPLORE: The Journal of Science and Healing [Journal]


Improved survival of glioblastoma patients treated at academic and high-volume facilities: a hospital-based study from the National Cancer Database.

J Neurosurg 2019 Feb 15:1-12. Epub 2019 Feb 15.

1The Vivian L. Smith Department of Neurosurgery, The University of Texas Health Science Center at Houston McGovern Medical School.

OBJECTIVEThe present study was designed to explore the association between facility type (academic center [AC] vs non-AC), facility volume (high-volume facility [HVF] vs low-volume facility [LVF]), and outcomes of glioblastoma (GBM) treatment.METHODSBased on the National Cancer Database (NCDB), GBM patients were categorized by treatment facility type (non-AC vs AC) and volume [4 categories (G1-G4): < 5.0, 5. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3171/2018.10.JNS182247DOI Listing
February 2019

Perceptions of the possible impact of dyslexia on nursing and midwifery students and of the coping strategies they develop and/or use to help them cope in clinical practice.

Authors:
Anna T Crouch

Nurse Educ Pract 2019 Jan 4;35:90-97. Epub 2019 Jan 4.

The University of Northampton, Faculty of Health and Society, Waterside Campus, University Drive, Northampton, NN1 5PH, United Kingdom. Electronic address:

This qualitative grounded theory case study aimed to explore the perceptions of the impact of dyslexia on nursing and midwifery students and of the coping strategies they develop and/or use to help them cope in practice. The questions addressed were: 1. What is the perceived impact of dyslexia on the nursing and midwifery student in clinical practice? 2. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.nepr.2018.12.008DOI Listing
January 2019

Long non-coding RNA activated by transforming growth factor beta alleviates lipopolysaccharide-induced inflammatory injury via regulating microRNA-223 in ATDC5 cells.

Int Immunopharmacol 2019 Feb 13;69:313-320. Epub 2019 Feb 13.

Department of Orthopaedics, China-Japan Union Hospital of Jilin University, Changchun 130033, Jilin, China. Electronic address:

Osteoarthritis (OA) is a conversant joint disease, which seriously threatens the health of the elderly, and even leads to disability. Long non-coding RNA-activated by transforming growth factor beta (lncRNA-ATB) has been reported in diverse cancers. However, the functions of lncRNA-ATB in OA remain uninvestigated. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.intimp.2019.01.056DOI Listing
February 2019

Impaired prefrontal cortex-thalamus pathway in intractable temporal lobe epilepsy with aberrant executive control function: MRI evidence.

Clin Neurophysiol 2019 Jan 18;130(4):484-490. Epub 2019 Jan 18.

Department of Radiology, Xuanwu Hospital, Capital Medical University, Beijing, PR China; Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics, Beijing, PR China. Electronic address:

Objectives: This study aimed to assess structural and functional connectivity alterations of the prefrontal cortex (PFC)-thalamus axis in individuals with unilateral intractable temporal lobe epilepsy (TLE) showing executive control function (ECF) impairment and to explore the potential mechanism.

Methods: Thirty-eight individuals with intractable left TLE and twenty-nine healthy controls (HCs) were recruited for diffusion tensor imaging (DTI) and resting-state fMRI (rs-fMRI) scanning. According to the ECF state, patients were assigned to normal and impaired ECF groups. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.clinph.2018.12.007DOI Listing
January 2019

SELDI-TOF MS Analysis of Hepatocellular Carcinoma in an Australian Cohort.

J Surg Res 2019 Feb 13;238:127-136. Epub 2019 Feb 13.

Cancer Surgery and Metabolism Research Group, University of Sydney, Kolling Institute of Medical Research, St Leonards, NSW, Australia; Upper GI Surgical Unit, Royal North Shore Hospital and North Shore Private Hospital, St Leonards, NSW, Australia; Discipline of Surgery, The University of Sydney, Camperdown, NSW, Australia.

Background: Hepatocellular carcinoma (HCC) is a common cause of cancer death worldwide. Resection offers the best chance of long-term survival, but a consistent adverse prognostic factor is the presence of microvascular invasion (MVI). In this study, surface-enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF MS), a high throughput method of analyzing complex samples, was used to explore differentially expressed proteins between HCC and adjacent nontumour liver tissue (ANLT). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jss.2019.01.008DOI Listing
February 2019

Facile thermal activation of non-reactive cryptocrystalline magnesite and its application on the treatment of acid mine drainage.

J Environ Manage 2019 Feb 13;236:499-509. Epub 2019 Feb 13.

Council for Scientific and Industrial Research (CSIR), Built Environment (BE), Hydraulic Infrastructure Engineering (HIE), P.O Box 395, Pretoria 0001, South Africa.

In this study, the authors report a facile thermal activation of non-reactive cryptocrystalline magnesite and explore its application on the treatment of acid mine drainage (AMD). The primary aim was to optimize the calcination-water interface reactive conditions. Parameters evaluated include calcination temperature, calcination time, AMD-calcination temperature interface, and AMD-calcination duration interface. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jenvman.2019.02.030DOI Listing
February 2019

Maternal employment and child health in Nepal: The importance of job type and timing across the child's first five years.

Soc Sci Med 2019 Feb 6;224:94-105. Epub 2019 Feb 6.

Population Studies Center, University of Michigan, 426 Thompson Street, P.O. Box 1248, Ann Arbor, MI, 48106-1248, USA; Institute for Social and Environmental Research Nepal, Bharatpur Metropolitan City, Ward No. 15, Chitwan, Nepal. Electronic address:

The increase in female labor force participation (FLFP) in the paid labor market since the mid-1900s is one of the most pronounced family transitions and increasingly a global phenomenon. While this may improve income and bargaining power of the women, it may also increase stress and decrease time with children. Using the Chitwan Valley Family Study in Nepal, we explore the consequences of this transition for children's health by combining newly collected data on child health outcomes, quarterly data on women's employment, and data on households and neighborhoods. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.socscimed.2019.02.009DOI Listing
February 2019

Depression is associated with diabetes status of family members: NHANES (1999-2016).

J Affect Disord 2019 Feb 6;249:121-126. Epub 2019 Feb 6.

School of Life Sciences, Beijing University of Chinese Medicine, Beijing, China. Electronic address:

Background: The majority of the studies in this area focus on the psychological impact of having diabetic children or adolescents on parents, while a limited number of studies have investigated the effect of diabetes on the mental health status of family members in the general population. Thus, the aim of the current study is to explore the possible association between mental health disorders (depression, anxiety and panic) and diabetes status of family members among a national sample of adults in the United States.

Methods: Our analysis included 1,787 and 25,574 participants in the National Health and Nutrition Examination Survey (NHANES) 1999-2004 and 2005-2016, respectively. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jad.2019.02.019DOI Listing
February 2019

Efficient and rapid removal of EDTA-chelated Pb(II) by the Fe(III)/flue gas desulfurization gypsum (FGDG) system.

J Colloid Interface Sci 2019 Jan 31;542:379-386. Epub 2019 Jan 31.

Jiangsu Key Laboratory of Chemical Pollution Control and Resources Reuse, School of Environmental and Biological Engineering, Nanjing University of Science and Technology, Nanjing 210094, China. Electronic address:

This study introduces the application of the Fe(III)/flue gas desulfurization gypsum (FGDG) system to remove EDTA-chelated Pb(II). Systematic experiments were conducted to explore the possibility of removing EDTA-chelated Pb(II) and the crucial factors of the removal process, as well as to determine the underlying removal mechanism. The results showed that the removal reaction was a quick process, with the removal rate exceeding 90% after 1 min. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jcis.2019.01.129DOI Listing
January 2019

TFAP2C-Activated MALAT1 Modulates the Chemoresistance of Docetaxel-Resistant Lung Adenocarcinoma Cells.

Mol Ther Nucleic Acids 2019 Jan 18;14:567-582. Epub 2019 Jan 18.

Department of Medical Oncology, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, Jiangsu 210002, China. Electronic address:

Chemoresistance remains a great obstacle in effective lung adenocarcinoma (LUAD) treatment. Previously, we verified the role of microRNA-200b (miR-200b) in the formation of docetaxel (DTX)-resistant LUAD cells. This study aims to investigate the mechanism underlying the low level of miR-200b in DTX-resistant LUAD cells. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.omtn.2019.01.005DOI Listing
January 2019

'Poetry in motion' a place in the classroom: Using poetry to develop writing confidence and reflective skills.

Nurse Educ Today 2019 Feb 6;76:73-77. Epub 2019 Feb 6.

University of Essex, Wivenhoe Park, Colchester CO4 3SQ, United Kingdom of Great Britain and Northern Ireland. Electronic address:

Background: Non-traditional students entering nursing programmes at university often experience difficulties with the academic literacy requirements of their courses, in particular academic and reflective writing. Levels of student anxiety may also be affected by other issues including the pressures of managing work, family and study commitments.

Objectives: To explore how classroom-based poetry writing activities might support students in developing their skills as student-writers and reflective practitioners. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.nedt.2019.01.026DOI Listing
February 2019

Exploring the experiences of early career academic nurses as they shape their career journey: A qualitative study.

Nurse Educ Today 2019 Feb 5;76:68-72. Epub 2019 Feb 5.

IMPACCT (Centre for Improving Palliative, Aged and Chronic Care through Clinical Research and Translation), University of Technology Sydney, Australia; Johns Hopkins University, Baltimore, MD, United States of America. Electronic address:

Objective: This study aimed to explore the experiences of early career academic nurses as they shape their career path in one Australian university.

Background: The early years of academic career development can be challenging as individuals learn to adjust to the teaching, research and service mission of universities. Tertiary institutions have an obligation to provide future nursing leaders with relevant and timely support during the formative phase of career development, to be successful in a competitive global environment. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.nedt.2019.01.021DOI Listing
February 2019

Student perceptions, experiences and support within their current Bachelor of Nursing.

Nurse Educ Today 2019 Feb 6;76:56-61. Epub 2019 Feb 6.

Western Sydney University, School of Nursing & Midwifery, Locked Bag 1797, Penrith, South NSW 2751, Australia. Electronic address:

Background: This study was developed to assist academics and curriculum designers to understand the perspectives and expectations of students when designing a program of study and inclusive of students as partners. The purpose of this qualitative study was to explore the perceptions and experiences of students enrolled in the Bachelor of Nursing (BN).

Settings, Participants, Methods: The setting is a multi-campus university in Australia. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.nedt.2019.01.032DOI Listing
February 2019

Mobile obstetric and neonatal simulation based skills training in India.

Midwifery 2019 Feb 7;72:14-22. Epub 2019 Feb 7.

Department of Paediatrics, Monash University, Melbourne, Australia.

Background: The developing world has a significantly high risk of women and babies dying during childbirth. Interprofessional simulation training has improved birth practices and outcomes by impacting clinical and non-technical skills like communication, teamwork, leadership and effective use of resources. While these programs have become a training requirement in many high-income countries, they have not been widely introduced in the low-income, low-resource settings. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.midw.2019.02.006DOI Listing
February 2019

A simple benzimidazole styryl-based colorimetric chemosensor for dual sensing application.

Spectrochim Acta A Mol Biomol Spectrosc 2019 Feb 7;214:111-118. Epub 2019 Feb 7.

Department of Chemistry, Institute of Chemical Technology, Matunga, Mumbai 400019, India. Electronic address:

A new colorimetric styryl-benzimidazole based receptor to recognize more than one analyte trans-2-[4'-(dimethylamino)styryl]benzimidazole) (L1) has been synthesized and fully characterized by C and H NMR, elemental analysis, UV-vis spectroscopy, and HRMS. Investigation of sensing ability of receptor L1 was carried out in presence of multiple anions (Br, CN, Cl, ClO, F, HSO, PF, NO, S, OH, AcO and HPO) and cations (Cu, Cr, Al, Mg, Cd, Ni, Fe, K, Fe, Mn, Ag, Hg, Ca, Co, Pb, Na, and Zn) by using UV-vis spectroscopy. Receptor L1 showed colorimetric response towards only for HSO ion. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.saa.2019.02.009DOI Listing
February 2019

Predictors of epilepsy presentation in unruptured brain arteriovenous malformations: a quantitative evaluation of location and radiomics features on T2 weighted imaging.

World Neurosurg 2019 Feb 13. Epub 2019 Feb 13.

Departments of Interventional Neuroradiology, Beijing Neurosurgical Institute and Beijing Tiantan Hospital, Capital Medical University, Beijing, China. Electronic address:

Objective: To explore predictors of epilepsy presentation in unruptured bAVMs with quantitative evaluation of location and radiomics features on T2 weighted imaging.

Methods: This retrospective study identified 117 patients with unruptured bAVMs. Cases were randomly split into training (n=90) and test dataset (n=27). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.wneu.2019.01.229DOI Listing
February 2019

Amelioration of adjuvant induced arthritis in Sprague Dawley rats through modulation of inflammatory mediators by Ribes alpestre Decne.

J Ethnopharmacol 2019 Feb 13. Epub 2019 Feb 13.

Prince Abdullah Ben Khaled Celiac Disease Research Chair, Department of Pediatrics, Faculty of Medicine, King Saud University, Riyadh, Saudi Arabia.

Ethnopharmacological Relevance: Ribes alpestre Decne has been commonly used in the treatment of joint complaints.

Aim Of Study: The present study was undertaken to evaluate the antiarthritic potential of ethanolic extract and fractions of Ribes alpestre and to explore its probable mechanism of action.

Material And Methods: Complete Freunds adjuvant induced arthritis in Sprague Dawley rats was used to assess antiarthritic activity of aqueous ethanol extract, butanol and aqueous fractions at 200mg/kg oral dose for 28 days. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jep.2019.02.025DOI Listing
February 2019

Human Papillomavirus Infection in Senegalese Female Sex Workers.

Papillomavirus Res 2019 Feb 13. Epub 2019 Feb 13.

Bacteriology-Virology Laboratory, CHU Aristide le Dantec, Dakar, Senegal.

Objectives: Several studies have documented the HPV genotypes in the Senegalese general population. The objective was to explore the HPV genotype distribution in Senegalese FSWs in order to assess the potential relevance of currently-available vaccines.

Methods: Vaginal swabs samples collected as part of the National Integrated Biological and Behavioral Survey in 14 regions throughout the country were randomly selected for HPV testing using bead-based multiplex genotyping (TS-MPG). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.pvr.2019.02.003DOI Listing
February 2019

Objective physical activity and physical performance in middle-aged and older adults.

Exp Gerontol 2019 Feb 13. Epub 2019 Feb 13.

Framingham Heart Study, Framingham, MA, USA; Department of General Internal Medicine, Boston University School of Medicine, Boston, MA, USA.

Background: Older adults may have difficulty meeting the Physical Activity (PA) Guidelines. A favorable balance between PA and sedentary time (SED) is an important determinant of physical performance in older adults. Our objective was to explore associations of PA/SED with physical performance across mid-older age in adults without overt mobility disability. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.exger.2019.02.003DOI Listing
February 2019

Comparative transcriptomics reveals mechanisms underlying cln3-deficiency phenotypes in Dictyostelium.

Cell Signal 2019 Feb 13. Epub 2019 Feb 13.

Department of Biology, Trent University, Peterborough, Ontario, Canada.

Mutations in CLN3 cause a juvenile form of neuronal ceroid lipofuscinosis (NCL). This devastating neurological disorder, commonly known as Batten disease, is currently untreatable due to a lack of understanding of the physiological role of the protein. Recently, work in the social amoeba Dictyostelium discoideum has provided valuable new insight into the function of CLN3 in the cell. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cellsig.2019.02.004DOI Listing
February 2019

p38 MAP kinases: plausible diagnostic and prognostic serum protein marker of non small cell lung cancer.

Exp Mol Pathol 2019 Feb 13. Epub 2019 Feb 13.

Department of Biophysics, All India Institute of Medical Sciences, New Delhi, India. Electronic address:

Introduction: p38 MAPK signaling molecules plays a dual role in cancer, both progression and suppression. Elevated expression of p38α was reported in lung cancer tissue in rat model. Our objective was to explore the concentration of all 4 isoforms of p38MAPK in serum of Non Small Cell Lung Cancer (NSCLC). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.yexmp.2019.01.009DOI Listing
February 2019

Enrichment of CLDN18-ARHGAP fusion gene in gastric cancers in young adults.

Cancer Sci 2019 Feb 16. Epub 2019 Feb 16.

Division of Screening for Molecular Target of Cancer, Graduate School of Medicine, Tohoku University, Sendai, Japan.

Gastric cancer in young adults has been pointed out to comprise a subgroup associated with distinctive clinicopathological features, including an equal gender distribution, advanced disease and diffuse-type histology. Comprehensive molecular analyses of gastric cancers have led to molecular-based classifications and to specific and effective treatment options available. The molecular traits of gastric cancers in young adults await investigations, which should provide a clue to explore therapeutic strategies. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/cas.13967DOI Listing
February 2019

Longitudinal assessment of cerebral blood flow changes following carotid artery stenting and endarterectomy.

Radiol Med 2019 Feb 15. Epub 2019 Feb 15.

Department of Radiology, Chinese PLA General Hospital, 28 Fuxing Road, Beijing, 100853, China.

Background: Carotid artery stenting (CAS) and endarterectomy (CEA) are major treatment strategies for patients with internal carotid artery (ICA) stenosis; however, the dynamic cerebral blood flow (CBF) changes after CAS and CEA remain unclear.

Purpose: This study aimed to monitor consecutive CBF changes at 24-h intervals in patients who underwent CAS and CEA to explore the potential pattern of CBF alternation and compare the effect on CBF changes of different surgical methods.

Methods: Thirty-two patients (28 males and 4 females; age = 63. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11547-018-00986-7DOI Listing
February 2019

Resveratrol Abrogates Hypoxia-Induced Up-Regulation of Exosomal Amyloid-β Partially by Inhibiting CD147.

Neurochem Res 2019 Feb 15. Epub 2019 Feb 15.

Department of Neurology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, 301 Middle Yanchang Road, Shanghai, 200072, China.

Hypoxia promotes both total extracellular and exosomal amyloid-β (Aβ) production and aggravates Alzheimer's disease (AD). Resveratrol (RSV) has been proved to be neuroprotective in AD models, and down-regulated the expression of CD147, an additional subunit of γ-secretase. In this study, we aimed to explore the role and mechanisms of RSV in hypoxia-induced upregulation of Aβ, especially exosomal Aβ. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11064-019-02742-3DOI Listing
February 2019

Community pharmacists' role in preventing opioid substitution therapy-related deaths: a qualitative investigation into current UK practice.

Int J Clin Pharm 2019 Feb 15. Epub 2019 Feb 15.

Department of Pharmacy and Pharmacology, University of Bath, C/O: 5 West 3.26, Claverton Down, Bath, BA2 7AY, UK.

Background Opioid substitution therapy involves prescribing of medical substitutes like methadone and buprenorphine to patients who are addicted to opioids. The majority of opioid substitution therapy dispensing in the UK is done by community pharmacists and they often see the patients on daily basis. It is unknown to what extent community pharmacists implement the policy to prevent overdose in patients receiving such treatment. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11096-019-00790-xDOI Listing
February 2019

A Comparison of Video Prompting to Least-to-Most Prompting among Children with Autism and Intellectual Disability.

J Autism Dev Disord 2019 Feb 15. Epub 2019 Feb 15.

Department of Teaching and Learning, Florida International University, 11200 S.W. 8th Street, Miami, FL, 33199, USA.

Students with autism spectrum disorder (ASD) and intellectual disability (ID) may experience challenges when learning tasks that are complex and require numerous steps. This difficulty can lead to employment issues for this population of learners. Therefore, researchers have explored methods to teach employment-related tasks to students with ASD and ID. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10803-019-03929-xDOI Listing
February 2019

Change in Mental Health Stigma After a Brief Intervention Among Internally Displaced Persons in Central Sudan.

Community Ment Health J 2019 Feb 15. Epub 2019 Feb 15.

Department of Public Health, Innlandet University Collage, Elverum, Norway.

Stigmatizing attitudes towards people with mental illness is a worldwide phenomenon, This Longitudinal study aimed to determine the level of stigma, among the internal displaced persons in central Sudan and explore possible changes in stigma associated with an intervention. 1549 persons were interviewed using standardized stigma attitude tools. The study reveled high level of stigma among our respondents and there was no significant difference in attitudes towards mental illness observed after the intervention. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10597-019-00375-yDOI Listing
February 2019

LATS2 Inhibits Malignant Behaviors of Glioma Cells via Inactivating YAP.

J Mol Neurosci 2019 Feb 15. Epub 2019 Feb 15.

Institute of Nervous System Diseases, Xuzhou Medical University, 84 West Huai-hai Road, Xuzhou, 221002, Jiangsu, People's Republic of China.

We previously reported that LATS2, the upstream serine/threonine kinase of Yes-associated protein (YAP), is downregulated in gliomas and exhibits negative correlation with the prognosis of glioma patients. In this work, we aimed to explore the role and mechanism of large tumor suppressor kinase (LATS2) in the progression of malignant gliomas. We found that over-expression of LATS2 inhibited glioma cell proliferation and migration/invasion, while LATS2 downregulation promoted them. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12031-019-1262-zDOI Listing
February 2019

Pathologic findings of the removed stomach during sleeve gastrectomy.

Surg Endosc 2019 Feb 15. Epub 2019 Feb 15.

Department of Bariatric Surgery, Orlando Regional Medical Center, Orlando Health, Orlando, FL, USA.

Background: Laparoscopic sleeve gastrectomy (LSG) is the preferred surgical intervention to treat morbid obesity. Despite the rising popularity of LSG, little is known on the histopathologic findings of the resected partial stomach specimens. Our study aims to identify prevalent pathologic findings of the removed stomach and explore the association between patient characteristics and abnormal findings. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00464-019-06689-yDOI Listing
February 2019

Impact of Peppermint Therapy on Dysphagia and Non-cardiac Chest Pain: A Pilot Study.

Dig Dis Sci 2019 Feb 15. Epub 2019 Feb 15.

Department of Medicine, Division of Gastroenterology and Hepatology, Medical University of South Carolina, 30 Courtenay Drive, Suite 249, MSC 702, Charleston, SC, 29425-2900, USA.

Background: Due to its smooth muscle relaxing properties, peppermint oil (PO) may relieve dysphagia and chest pain due to esophageal motility disorders.

Aim: To explore the impact of PO on dysphagia and/or chest pain in patients referred for motility testing.

Methods: Patients initiated on PO for dysphagia and/or chest pain from 2013 to 2016 were identified. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10620-019-05523-8DOI Listing
February 2019

Diabetes Management in Older Adults With Chronic Kidney Disease.

Curr Diab Rep 2019 Feb 15;19(3):11. Epub 2019 Feb 15.

Department of Medicine, Division of Nephrology, Stanford University School of Medicine, Stanford, CA, USA.

Purpose Of Review: Older adults often live with chronic disease including diabetes and its complications. In this review, we examine the complexity and heterogeneity of older adults with diabetes and chronic kidney disease, explore the nuances in their diabetes-related monitoring, and discuss their best diabetes management.

Recent Findings: Although there remains an overall lack of studies in older adults with diabetes and chronic kidney disease, recent reports have highlighted their vulnerabilities. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11892-019-1128-3DOI Listing
February 2019

Investigation of Urinary Sestrin2 in Patients with Obstructive Sleep Apnea.

Lung 2019 Feb 15. Epub 2019 Feb 15.

Department of Respiratory and Critical Care Medicine, First Affiliated Hospital, Kunming Medical University, Kunming, China.

Background: Obstructive sleep apnea (OSA) is a disease seriously threatening individual health, which results in serious complications such as hypertension and stroke. These complications are associated with oxidative stress triggered by intermittent hypoxia in OSA. Sestrin2 is a crucial factor involved in oxidative stress. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00408-019-00205-8DOI Listing
February 2019

Energy drinks in children and adolescents: demographic data and immediate effects.

Eur J Pediatr 2019 Feb 15. Epub 2019 Feb 15.

Pediatric Department, Saint Vincent De Paul Hospital, Faculty of Medicine, Bar-Ilan University, PO box 50294, 16102, Nazareth, Israel.

Energy drinks consumption has become increasingly common in the last few years, despite evidence associating these products with vast adverse health effects. This led us to explore the phenomenon of energy drinks consumption in adolescents in the Israeli Arab population of the Nazareth area (Northern Israel), examining their awareness of risks associated with consumption of energy drinks, investigating their immediate effects on the body. Our study revealed that the consumption of energy drinks is very common in adolescents of both sexes, though more common in boys. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00431-019-03342-7DOI Listing
February 2019

Determinants of disease severity among patients with atopic dermatitis: association with components of the atopic march.

Arch Dermatol Res 2019 Feb 15. Epub 2019 Feb 15.

Department of Dermato-venereology, Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark.

We aimed to explore the association of key clinical characteristics with disease severity in atopic dermatitis (AD) and its relation to components of the atopic march in a large hospital cohort. Outpatients with AD referred to the Department of Dermatology, Bispebjerg Hospital, Copenhagen, Denmark, between January 2012 and December 2017, were compared based on disease severity (SCORAD); mild (< 25), moderate (25-50) and severe (> 50). A total of 470 AD patients were included: 122 small children (< 4 years of age), 103 children/adolescents (age 4-15 years) and 245 adults (> 15 years of age). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00403-019-01895-zDOI Listing
February 2019

Multi-cohort study identifies social determinants of systemic inflammation over the life course.

Nat Commun 2019 Feb 15;10(1):773. Epub 2019 Feb 15.

LEASP, UMR 1027, Inserm-Université Toulouse III Paul Sabatier, Toulouse, 31000, France.

Chronic inflammation has been proposed as having a prominent role in the construction of social inequalities in health. Disentangling the effects of early life and adulthood social disadvantage on inflammation is key in elucidating biological mechanisms underlying socioeconomic disparities. Here we explore the relationship between socioeconomic position (SEP) across the life course and inflammation (as measured by CRP levels) in up to 23,008 participants from six European cohort studies from three countries conducted between 1958 and 2013. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41467-019-08732-xDOI Listing
February 2019

A multi-substrate screening approach for the identification of a broadly applicable Diels-Alder catalyst.

Nat Commun 2019 Feb 15;10(1):770. Epub 2019 Feb 15.

Max-Planck-Institut für Kohlenforschung, Kaiser-Wilhelm-Platz 1, D-45470, Mülheim an der Ruhr, Germany.

When developing a synthetic methodology, chemists generally optimize a single substrate and then explore the substrate scope of their method. This approach has led to innumerable and widely-used chemical reactions. However, it frequently provides methods that only work on model substrate-like compounds. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41467-019-08374-zDOI Listing
February 2019

Autoantibody against β-adrenoceptor promotes the differentiation of natural regulatory T cells from activated CD4 T cells by up-regulating AMPK-mediated fatty acid oxidation.

Cell Death Dis 2019 Feb 15;10(3):158. Epub 2019 Feb 15.

Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Capital Medical University, 100069, Beijing, China.

Therapeutic adoptive transfer of natural regulatory T cells (nTreg, CD4 CD25 Foxp3 T cells) or in vivo selective expansion of nTreg cells has been demonstrated to improve the cardiac function in various cardiovascular disease models. The differentiation of nTreg cells is mediated by catecholamines via β-adrenergic receptor (β-AR) activation. Autoantibody against β-adrenoceptor (β-AA) as a β-AR agonist is closely associated with the occurrence and deterioration of cardiac dysfunction. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41419-018-1209-2DOI Listing
February 2019

Social determinants and cardiovascular disease mortality in Panama, 2012-2016.

BMC Public Health 2019 Feb 15;19(1):199. Epub 2019 Feb 15.

Gorgas Memorial Institute for Health Studies, Panama City, Panama.

Background: The aims of this study were to determine the geographic and time variation of social determinants of health (SDH) and cardiovascular disease (CVD) mortality in Panama from 2012 to 2016, and to identify which of the SDH has the strongest correlation with a socioeconomic index (SEI).

Methods: We conducted an ecological study obtaining mortality from the National Mortality Register and socioeconomic variables derived from the National Household Survey (NHS). The International Classification of Diseases 10th revision codes I20-I25 and I60-I69 were used for ischemic heart disease (IHD) and stroke, respectively. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12889-019-6508-8DOI Listing
February 2019

Resilience acts as a moderator in the relationship between infertility-related stress and fertility quality of life among women with infertility: a cross-sectional study.

Health Qual Life Outcomes 2019 Feb 15;17(1):38. Epub 2019 Feb 15.

Department of Social Medicine, School of Public Health, China Medical University, No.77 Puhe Road, Shenyang North New Area, Shenyang, 110122, China.

Background: Infertility-related stress can seriously impact the fertility quality of life (QoL) of infertile women. Resilience, as a coping resource, can effectively combat psychological stress. This study aimed to evaluate the fertility QoL of infertile women and to examine whether resilience moderates the association of infertility-related stress with fertility QoL. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12955-019-1099-8DOI Listing
February 2019

The expression profile analysis of atrial mRNA in rats with atrial fibrillation: the role of IGF1 in atrial fibrosis.

BMC Cardiovasc Disord 2019 Feb 15;19(1):40. Epub 2019 Feb 15.

Department of Cardiology, Shandong Provincial Qianfoshan Hospital, Shandong University, No. 16766 Jingshi Road, 250014, Jinan, People's Republic of China.

Background: Structural remodeling is critical to the initiation and maintenance of atrial fibrillation (AF). IGF1, insulin like growth factor 1, has been recognized as contributor to fibrosis. However, the roles and mechanisms of IGF1 in structural remodeling during AF is still unclear. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12872-019-1013-7DOI Listing
February 2019

[Consideration of Application of Insulin Pen Needles and Supervision].

Authors:
Na Zhan

Zhongguo Yi Liao Qi Xie Za Zhi 2019 Jan;43(1):63-64

Center for Medical Device Evaluation, CFDA, Beijing, 100081.

With the increasing incidence of diabetes mellitus in China, hypodermic injection of artificial insulin to control blood sugar has been popularized. Insulin pen needles are widely used in hospitals, communities and families. This article attempts to explore and think about the harm and countermeasures brought about by the reuse of insulin pen needles from the perspective of medical device supervision. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3969/j.issn.1671-7104.2019.01.016DOI Listing
January 2019

Low-intensity pulsed ultrasound combination with iPSCs-NCSCs and GDF5 promotes sciatic nerve regeneration and functional recovery.

J Tissue Eng Regen Med 2019 Feb 15. Epub 2019 Feb 15.

Key Laboratory of Biorheological Science and Technology (Chongqing University), Ministry of Education, Bioengineering College, Chongqing University, Chongqing, P. R. China.

The treatment of lengthy peripheral nerve defect is challenging in the field of nerve regeneration. Our previous studies have shown that low-intensity pulsed ultrasound (LIPUS) could promote the proliferation, cell viability, and neural differentiation of induced pluripotent stem cells-derived neural crest stem cells (iPSCs-NCSCs) and improve the regeneration of damaged peripheral nerve. In this study, the mechanical signal transduction pathway of LIPUS promoting iPSCs-NCSCs proliferation and differentiation was further explored, and the effects of LIPUS combined with iPSCs-NCSCs, perfluorotributylamine (PFTBA), and growth differentiation factor 5 (GDF5) on the repair of peripheral nerve injury were evaluated. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/term.2823DOI Listing
February 2019

LEF1-AS1, long non-coding RNA, inhibits proliferation in myeloid malignancy.

J Cell Mol Med 2019 Feb 15. Epub 2019 Feb 15.

Hematology and Hemotherapy Center, Hemocentro-Unicamp, São Paulo, Brazil.

LEF1 antisense RNA 1 (LEF1-AS1) is an antisense long non-coding RNA encoded in the lymphoid enhancer-binding factor 1 (LEF1) locus. LEF1-AS1 is a conserved transcript dysregulated in hematopoiesis. This study aimed to functionally characterize the role of this transcript in myeloid malignancy and explore a possible regulatory effect of LEF1-AS1 upon LEF1. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jcmm.14152DOI Listing
February 2019

The burden of proof: The process of involving young people in research.

Health Expect 2019 Feb 15. Epub 2019 Feb 15.

Institute of Health and Society, Newcastle University, Newcastle upon Tyne, UK.

Patient and public involvement in research includes non-academics working with researchers, on activities from consultative tasks, to joint working, and on user-led initiatives. Health and social care funding bodies require involvement in research projects. A current debate focuses on a perceived lack of empirical "proof" to demonstrate the impact of involvement upon the quality of research. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/hex.12870DOI Listing
February 2019

Ras-PI3K-AKT signaling promotes the occurrence and development of uveal melanoma by downregulating H3K56ac expression.

J Cell Physiol 2019 Feb 15. Epub 2019 Feb 15.

Department of Vascular Surgery, China-Japan Union Hospital of Jilin University, Changchun, Jilin, China.

Background: Uveal melanoma (UM) is an intraocular malignant tumor characterized by rapid progression and recurrence. The current conventional treatments are unsatisfactory. Histone acetylation at H3 lysine 56 (H3K56ac) has been reported to be a tumor suppressor in breast cancer. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jcp.28261DOI Listing
February 2019

Tetramethylpyrazine partially relieves hypoxia-caused damage of cardiomyocytes H9c2 by downregulation of miR-449a.

J Cell Physiol 2019 Feb 15. Epub 2019 Feb 15.

Department of Cardiovascular Surgery, Heze Municipal Hospital, Heze, China.

Inadequate oxygen supply is probably one of the most important pathophysiological mechanisms of cardiomyocyte damage in ischemic heart disease. Tetramethylpyrazine (TMP, also known as ligustrazine) is the main active ingredient isolated from the rhizome of Ligusticum chuanxiong Hort. A previous study reported that the TMP could exert cardioprotective activity. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jcp.28151DOI Listing
February 2019

Live Music Therapy During Rehabilitation After Total Knee Arthroplasty: A Randomized Controlled Trial.

Authors:
Hakeem Leonard

J Music Ther 2019 Feb;56(1):61-89

Shenandoah University, Winchester, VA, USA.

Total knee arthroplasty (TKA) is a common orthopedic surgery known to be very painful. Emphasis has been placed on TKA pain management for postoperative care and during rehabilitation. Music therapy is used as a nonpharmacologic intervention for pain management and to promote rehabilitation exercise adherence. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/jmt/thy022DOI Listing
February 2019

Outcomes of a Course-based Undergraduate Research Experience (CURE) for Music Therapy and Music Education Students.

J Music Ther 2019 Feb;56(1):30-60

Arizona State University, Tempe, AZ, USA.

Course-based undergraduate research experiences (CUREs) involve entire classes of students researching a question or problem that is of interest to the scholarly community with an unknown outcome to both students and instructor. The purpose of this pre-experimental one-group posttest design study was to explore outcomes of a CURE for music therapy and music education students enrolled in a music psychology course. Specifically, we examined differences in scientific thinking, personal gains, research skills, and attitudes and behaviors of students resulting from their participation in a CURE experience, as well as students' perceived benefits of a CURE experience. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/jmt/thy020DOI Listing
February 2019

A Dose Finding Study of a Wild-Type Influenza A/H3N2 virus in a Healthy Volunteer Human Challenge Model.

Clin Infect Dis 2019 Feb 16. Epub 2019 Feb 16.

LID Clinical Studies Unit, Viral Pathogenesis and Evolution Section, Laboratory of Infectious Diseases, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.

Background: The development of vaccines and therapeutics have relied on healthy volunteer influenza challenge studies. A validated human infection model with wild-type A(H1N1)pdm09 was reported previously.

Objective: To characterize a wild-type Influenza A/Bethesda/MM1/H3N2 challenge virus in healthy volunteers. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/cid/ciz141DOI Listing
February 2019

Exploring barriers and challenges in protecting residential fire-related injuries: a qualitative study.

J Inj Violence Res 2019 Feb 16;11(1). Epub 2019 Feb 16.

Safety Promotion and Injury Prevention Research Center, School of Public Health and Safety, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Background: Building fires can be a great threat to the safety of residents, and can lead to economic and social damage. Exploring the views of stakeholders is a great source for understanding the factors that affect fires. The purpose of this study was to explore stakeholders' experiences of unintentional fire-related injuries in residential buildings in Iran. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5249/jivr.v11i1.1059DOI Listing
February 2019