328,107 results match your criteria EXPLORE: The Journal of Science and Healing [Journal]


Convergent neural connectivity in motor impulsivity and high-fat food binge-like eating in male Sprague-Dawley rats.

Neuropsychopharmacology 2019 Apr 19. Epub 2019 Apr 19.

Center for Addiction Research and Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, TX, USA.

Food intake is essential for survival, but maladaptive patterns of intake, possibly encoded by a preexisting vulnerability coupled with the influence of environmental variables, can modify the reward value of food. Impulsivity, a predisposition toward rapid unplanned reactions to stimuli, is one of the multifaceted determinants underlying the etiology of dysregulated eating and its evolving pathogenesis. The medial prefrontal cortex (mPFC) is a major neural director of reward-driven behavior and impulsivity. Read More

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http://dx.doi.org/10.1038/s41386-019-0394-8DOI Listing

Wax esters of uropygial gland secretion as biomarkers of endocrine disruption in birds exposed to treated sewage water.

Environ Pollut 2019 Apr 10;250:323-330. Epub 2019 Apr 10.

Instituto de Investigación en Recursos Cinegéticos, IREC (CSIC, UCLM, JCCM), Ronda de Toledo 12, 13005, Ciudad Real, Spain. Electronic address:

The chemical composition of the uropygial gland secretion of birds shows seasonal, sex and age-related variations following sex hormones fluctuations. We explore the use of the composition of the uropygial gland secretion as a non-invasive biomarker of endocrine disruption in 137 common moorhens (Gallinula chloropus) from Navaseca Pond, which receives the effluent of a wastewater treatment plant, and from the more pristine Tablas de Daimiel National Park in Spain. Wax ester and fatty acid compositions were measured by means gas chromatography - mass spectrometry (GC-MS) in the uropygial gland secretion of moorhens from both wetlands. Read More

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http://dx.doi.org/10.1016/j.envpol.2019.04.039DOI Listing

Trajectories of PTSD symptoms among children who survived the Lushan earthquake: A four-year longitudinal study.

J Affect Disord 2019 Apr 9;252:421-427. Epub 2019 Apr 9.

CAS Key Laboratory of Mental Health, Institute of Psychology, 16 Lincui Road, Chaoyang District, Beijing 100101, China. Electronic address:

Background: This study aimed to explore the trajectories of posttraumatic stress disorder (PTSD) symptoms among child survivors of the Lushan earthquake by using latent category growth analysis.

Methods: In total, 304 students from a school located in Lushan County were assessed by UCLA PTSD-RI at 1.5, 6, 12, 24 and 48 months after the earthquake. Read More

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http://dx.doi.org/10.1016/j.jad.2019.04.047DOI Listing
April 2019
2 Reads

Bioaccessibility estimates by gastric SBRC method to determine relationships to bioavailability of nickel in ultramafic soils.

Sci Total Environ 2019 Apr 6;673:685-693. Epub 2019 Apr 6.

School of Environmental Sciences, University of Guelph, Guelph, ON, Canada.

Frameworks for human health risk assessment often include the opportunity to correct the estimate of exposure for bioavailability, which could be predicted from bioaccessibility. Lead and As are the only metallic elements for which bioavailability and bioaccessibility have been correlated across a spectrum of mineralogy and particle types. The objective of the present study is to correlate in vivo bioavailability with ex vivo bioaccessibility for elevated Ni in soils of ultramafic origin and explore attribution of any variation in this correlation to mineralogical characterization of the Ni. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2019.04.059DOI Listing

LncRNA ENST00000602558.1 regulates ABCG1 expression and cholesterol efflux from vascular smooth muscle cells through a p65-dependent pathway.

Atherosclerosis 2019 Apr 8;285:31-39. Epub 2019 Apr 8.

Key Laboratory of Cardiovascular Epidemiology & Department of Epidemiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, 167 Beilishi Road, Beijing 100037, China.

Background And Aims: Long non-coding RNAs (lncRNAs) have proven to be involved in the progression of atherosclerosis and dyslipidemia. In addition, vascular smooth muscle cells (VSMCs) phenotype switching, including VSMCs-derived foam cells formation, plays a key role in the pathogenesis of atherosclerosis. LncRNA ENST00000602558. Read More

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http://dx.doi.org/10.1016/j.atherosclerosis.2019.04.204DOI Listing

Unconscious versus conscious thought in creative science problem finding: Unconscious thought showed no advantage!

Conscious Cogn 2019 Apr 16;71:109-113. Epub 2019 Apr 16.

Department of Psychology, Education and Child Studies, Erasmus University, Rotterdam, the Netherlands.

Unconscious thought theory (UTT) suggests that creativity benefits more from unconscious thought than conscious thought. However, previous studies have only focused on creative problem solving. This study aims to explore the effect of unconscious thought and conscious thought in creative science problem finding (CSPF). Read More

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http://dx.doi.org/10.1016/j.concog.2019.03.010DOI Listing
April 2019
2 Reads

Red blood cell membrane cholesterol in type 2 diabetes mellitus.

Thromb Res 2019 Apr 7;178:91-98. Epub 2019 Apr 7.

Department of Physiological Sciences, Stellenbosch University, Stellenbosch, Private Bag X1 Matieland, 7602, South Africa. Electronic address:

Type II diabetes mellitus (T2DM) affects an estimate of 450 million individuals. Hence, there remains an urgent need to explore the use of novel biomarkers with the aim of preventing and managing cardiovascular risk among these individuals. Hallmarks of this condition are lipid and glucose dyshomeostasis which are accompanied by a prothrombotic phenotype; these pose as eminent links between T2DM and cardiovascular disease. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00493848193018
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http://dx.doi.org/10.1016/j.thromres.2019.04.005DOI Listing
April 2019
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Psychological Distress among Adolescents in Laos, Mongolia, Nepal, and Sri Lanka.

Asian Nurs Res (Korean Soc Nurs Sci) 2019 Apr 16. Epub 2019 Apr 16.

Hanyang University, College of Medicine, Department of Preventive Medicine; Hanyang University, Institute for Health and Society, Seoul, Republic of Korea.

Purpose: The purpose of this study was to explore psychological distress and examine the relationship between this distress and individual, family, and school factors among adolescents in four low- and middle-income countries (LAMICs) in Asia (i.e., Laos, Mongolia, Nepal, and Sri Lanka). Read More

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http://dx.doi.org/10.1016/j.anr.2019.04.001DOI Listing

PM2.5 induces EMT and promotes CSC properties by activating Notch pathway in vivo and vitro.

Ecotoxicol Environ Saf 2019 Apr 16;178:159-167. Epub 2019 Apr 16.

Department of Respiratory and Critical Care Medicine, Peking University First Hospital, Beijing, China. Electronic address:

Fine particulate matter (PM2.5) has been closely linked to increased morbidity and mortality of lung cancer worldwide. However, the role of PM2. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01476513193035
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http://dx.doi.org/10.1016/j.ecoenv.2019.03.086DOI Listing
April 2019
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"I was considering surgery because I believed that was how it was treated": A qualitative study on willingness for joint surgery after completion of a digital management program for osteoarthritis.

Osteoarthritis Cartilage 2019 Apr 16. Epub 2019 Apr 16.

Department of Health Sciences, Lund University, Lund, Sweden; The PRO-CARE Group, School of Health and Society, Kristianstad University, Kristianstad, Sweden.

Objective: To explore, using a qualitative approach, reasons for patients' continued willingness or their shift in willingness for total joint replacement (TJR) surgery, following participation in Joint Academy, a Swedish, digital, non-surgical treatment program for osteoarthritis (OA).

Design: Nineteen patients with hip or knee OA were interviewed after finishing their first six weeks in the treatment program, using a semi-structured interview guide. The interviews were transcribed verbatim and analyzed using a systematic text condensation method. Read More

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http://dx.doi.org/10.1016/j.joca.2019.04.004DOI Listing

Abnormality of hepatic triglyceride metabolism in Apc mice with colon cancer cachexia.

Life Sci 2019 Apr 16. Epub 2019 Apr 16.

Jilin Provincial Key Laboratory of Animal Embryo Engineering, College of Animal Sciences, Jilin University, No.5333 Xi'an Road, Lvyuan District, Changchun 130062, Jilin Province, China. Electronic address:

Aims: Colorectal cancer syndrome has been one of the greatest concerns in the world. Although several epidemiological studies have shown that hepatic low lipoprotein lipase (LPL) mRNA expression may be associated with dyslipidemia and tumor progression, it is still not known whether the liver plays an essential role in hyperlipidemia of Apc mice.

Main Methods: We measured the expression of metabolic enzymes that involved fatty acid uptake, de novo lipogenesis (DNL), β-oxidation and investigated hepatic triglyceride production in the liver of wild-type and Apc mice. Read More

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http://dx.doi.org/10.1016/j.lfs.2019.04.041DOI Listing

Maternal hyperuricemia superimposed on maternal hypertension aggravates the risk of small-for-gestational-age fetus.

Life Sci 2019 Apr 16. Epub 2019 Apr 16.

Department of Endocrinology, Shandong Provincial Hospital affiliated to Shandong University, Institute of Endocrinology and Metabolism, Shandong Academy of Clinical Medicine, Shandong Clinical Medical Center of Endocrinology and Metabolism, Jinan, Shandong 250021, China. Electronic address:

Aims: Small-for-gestational-age (SGA) fetus is an important public health issue because of its high mortality and long-term effects on health. Maternal hyperuricemia is associated with diverse adverse pregnant outcomes and neonatal disturbance. We aimed to evaluate whether maternal hyper-uric acid (HUA) is associated with the risk of SGA fetus and to explore whether it can modify the association between maternal hyper-blood pressure (HBP) and SGA fetus. Read More

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http://dx.doi.org/10.1016/j.lfs.2019.04.033DOI Listing

Protective Effects of Mesenchymal Stem Cells Overexpressing Extracellular Regulating Kinase 1/2 Against Stroke in Rats.

Brain Res Bull 2019 Apr 16. Epub 2019 Apr 16.

Department of Neurology, Shanghai Tongji hospital, Tongji University School of Medicine, Shanghai, 200065, China. Electronic address:

Objective: Although transplantation of bone marrow-derived mesenchymal stem cells (MSCs) has shown beneficial effects on stroke, lower survival of MSCs limits effects. Extracellular regulating kinase 1/2 signaling (ERK1/2) is crucial for cell survival, differentiation, and proliferation. This study was designed to explore whether MSCs modified by over-expressing ERK1/2 may reinforce beneficial effects on stroke in rats. Read More

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http://dx.doi.org/10.1016/j.brainresbull.2019.04.006DOI Listing

NF-κB inhibitor, BAY11-7082, suppresses M2 tumor-associated macrophage induced EMT potential via miR-30a/NF-κB/Snail signaling in bladder cancer cells.

Gene 2019 Apr 16. Epub 2019 Apr 16.

Department of Ultrasonography, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou 310014, China. Electronic address:

Background: Chronic inflammatory microenvironment has been shown to play a key role in initiating tumorigenesis and facilitating malignant progression. Primary tumors surrounded with and infiltrated by tumor-associated macrophages (TAMs) significantly promote the epithelial-to-mesenchymal transition (EMT) and distant metastasis in urothelial bladder cancer.

Methods: In this study, we aimed to explore the potential of targeting TAMs for the treatment of malignant bladder cancer. Read More

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http://dx.doi.org/10.1016/j.gene.2019.04.039DOI Listing

Antileishmanial activity of H1-antihistamine drugs and cellular alterations in Leishmania (L.) infantum.

Acta Trop 2019 Apr 16. Epub 2019 Apr 16.

Center for Parasitology and Mycology, Instituto Adolfo Lutz, Sao Paulo, Brazil. Electronic address:

Leishmaniases are infectious diseases caused by protozoan parasites Leishmania and transmitted by sand flies. Drug repurposing is a therapeutic approach that has shown satisfactory results in their treatment. Analyses of antihistaminic drugs have revealed their in vitro and in vivo activity against trypanosomatids. Read More

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http://dx.doi.org/10.1016/j.actatropica.2019.04.017DOI Listing

Assessor teaching and the development of the capacity to innovate and to imitate.

J Theor Biol 2019 Apr 16. Epub 2019 Apr 16.

Departamento de Producción Agraria, ETSIAAB-UPM, Spain. Electronic address:

Human beings have generated a system of cumulative cultural learning with great adaptive value. The evolution of this system required an increase in the capacity to innovate and to imitate in hominin lineage. However that development is costly and, moreover, imitation may restrain the adaptive advantage of a greater investment on innovation. Read More

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http://dx.doi.org/10.1016/j.jtbi.2019.04.004DOI Listing

Core catalysis of the reductive glycine pathway demonstrated in yeast.

ACS Synth Biol 2019 Apr 19. Epub 2019 Apr 19.

One-carbon (C1) compounds are attractive microbial feedstocks as they can be efficiently produced from widely available resources. Formate, in particular, represents a promising growth substrate, as it can be generated from electrochemical reduction of CO2 and fed to microorganisms in a soluble form. We previously identified the synthetic reductive glycine pathway as the most efficient route for aerobic growth on formate. Read More

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http://pubs.acs.org/doi/10.1021/acssynbio.8b00464
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http://dx.doi.org/10.1021/acssynbio.8b00464DOI Listing
April 2019
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Biogenesis, quality control and structural dynamics of proteins as explored in living cells via site-directed photo-crosslinking.

Protein Sci 2019 Apr 19. Epub 2019 Apr 19.

State Key Laboratory of Protein and Plant Gene Research, School of Life Sciences, Peking University, Center for Protein Science, Beijing 100871, China.

Protein biogenesis and quality control are essential for maintaining a functional pool of proteins and involve numerous protein factors that dynamically and transiently interact with each other and with the substrate proteins in living cells. Conventional methods are hardly effective for studying such dynamic, transient, and weak protein-protein interactions as occur in cells. Herein we review how the site-directed photo-crosslinking approach, which relies on the genetic incorporation of a photo-reactive unnatural amino acid into a protein of interest at selected individual amino acid residue position and the covalent trapping of the interacting proteins upon ultraviolent (UV) irradiation, has become a highly efficient way to explore these aspects of protein contacts in living cells. Read More

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http://dx.doi.org/10.1002/pro.3627DOI Listing

Fluctuating environments select for short-term phenotypic variation leading to long-term exploration.

PLoS Comput Biol 2019 Apr 19;15(4):e1006445. Epub 2019 Apr 19.

Department of Computer Science and Engineering, Michigan State University, East Lansing, MI, USA.

Genetic spaces are often described in terms of fitness landscapes or genotype-to-phenotype maps, where each genetic sequence is associated with phenotypic properties and linked to other genotypes that are a single mutational step away. The positions close to a genotype make up its "mutational landscape" and, in aggregate, determine the short-term evolutionary potential of a population. Populations with wider ranges of phenotypes in their mutational neighborhood are known to be more evolvable. Read More

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http://dx.doi.org/10.1371/journal.pcbi.1006445DOI Listing

Larger Area Facilitates Richness-Function Effects in Experimental Microcosms.

Am Nat 2019 May 18;193(5):738-747. Epub 2019 Mar 18.

Species-area relationships (SAR) and biodiversity-ecosystem function (BEF) relationships are central patterns in community ecology. Although research on both patterns often invokes mechanisms of community assembly, both SARs and BEFs are generally treated as separate phenomena. Here we link the two by creating an experimental SAR in microcosm communities and show that greater species richness in larger areas is accompanied by greater ecosystem function. Read More

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http://dx.doi.org/10.1086/702705DOI Listing

When Do Shifts in Trait Dynamics Precede Population Declines?

Am Nat 2019 May 27;193(5):633-644. Epub 2019 Mar 27.

Predicting population responses to environmental change is an ongoing challenge in ecology. Studies investigating the links between fitness-related phenotypic traits and demography have shown that trait dynamic responses to environmental change can sometimes precede population dynamic responses and thus can be used as an early warning signal. However, it is still unknown under which ecological and evolutionary circumstances shifts in fitness-related traits can precede population responses to environmental perturbation. Read More

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http://dx.doi.org/10.1086/702849DOI Listing

Emergency nurses' perceptions of their roles and practices during epidemics: a qualitative study.

Br J Nurs 2019 Apr;28(8):523-527

Professor, the Chinese University of Hong Kong, New Territories, Hong Kong.

Background: although emergency nurses have a pivotal role in the public health response to epidemics, little is known about their responsibilities and practice in terms of epidemic management.

Aims: this study aimed to explore how emergency nurses understand and perform their professional roles and practice during epidemics.

Methods: a qualitative descriptive study design was used. Read More

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http://dx.doi.org/10.12968/bjon.2019.28.8.523DOI Listing
April 2019
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International scoping exercise into expertise in children's orthopaedic nursing and educational pathways.

Authors:
Julia Judd

Br J Nurs 2019 Apr;28(8):518-522

Advanced Nurse Practitioner, Southampton University Hospital.

Maintaining competence and keeping skills and knowledge in children's orthopaedic nursing alive are problematic in both the UK and Australia. The dearth of dedicated postgraduate courses for this specialty has resulted in an array of unregulated in-house training, nurses' individual educational needs not being met and potential for children with an orthopaedic problem being put at risk of not receiving optimal care. This paper reports on a travel scholarship used to compare and contrast the UK with Australia, which supported an international scoping exercise to identify nurses' beliefs regarding expertise in children's orthopaedic nursing and explore provision for maintaining pertinent knowledge and skills. Read More

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http://dx.doi.org/10.12968/bjon.2019.28.8.518DOI Listing

Pediatric drug safety signal detection of non-chemotherapy drug-induced neutropenia and agranulocytosis using electronic healthcare records.

Expert Opin Drug Saf 2019 Apr 19:1-7. Epub 2019 Apr 19.

a Clinical Research Center , National Center for Children's Health, Beijing Children's Hospital, Capital Medical University , Beijing , China.

Objectives: This study aimed to develop a procedure to explore the adverse drug reaction signals of drug-induced neutropenia (DIN) or drug-induced agranulocytosis (DIA) in children using an electronic health records (EHRs) database.

Methods: A two-stage design was presented. First, the suspected drugs to induce DIN or DIA were selected. Read More

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http://dx.doi.org/10.1080/14740338.2019.1604682DOI Listing

Assessing for Fetal Alcohol Spectrum Disorder.

J Popul Ther Clin Pharmacol 2019 Jan 23;26(1):e39-e55. Epub 2019 Jan 23.

Canada FASD Research Network.

Background The recommended "gold standard" for Fetal Alcohol Spectrum Disorder (FASD) assessment involves a multidisciplinary diagnostic team and comprehensive battery of neuropsychological tests to evaluate functioning across 10 brain domains. The current Canadian Guideline for diagnosis of FASD outlines a list of test measures for assessment; however, very little research exists to explore which specific tools are being used in clinical practice. Objectives The purpose of the current study was to gain a better understanding of the testing measures used by FASD clinicians in Alberta, Canada. Read More

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http://jptcp.com/index.php/jptcp/article/view/54
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http://dx.doi.org/10.22374/1710-6222.26.1.4DOI Listing
January 2019
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Heterogeneous macrophages: supersensors of exogenous inducing factors.

Scand J Immunol 2019 Apr 19:e12768. Epub 2019 Apr 19.

School of Basic Medical Sciences, Nanchang University, Nanchang, Jiangxi, 330006, China.

As heterogeneous immune cells, macrophages mount effective responses to various internal and external changes during disease progression. Macrophage polarization, rather than macrophage heterogenization, is often used to describe the functional differences between macrophages. While macrophage polarization partially contributes to heterogeneity, it does not completely explain the concept of macrophage heterogeneity. Read More

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http://dx.doi.org/10.1111/sji.12768DOI Listing

Why the c-Fos/c-Jun complex is extremely conserved: An in vitro evolution exploration by combining cDNA display and proximity ligation.

FEBS Lett 2019 Apr 19. Epub 2019 Apr 19.

Hubei Key Laboratory of Agricultural Bioinformatics, College of Informatics, Huazhong Agricultural University, Wuhan, 430070, P. R. China.

Transcriptional regulation involves a series of sophisticated protein-protein and protein-DNA interactions (PPI and PDI). Some transcriptional complexes, such as c-Fos/c-Jun and their binding DNA fragments, have been conserved over the past one billion years. Considering the thermodynamic principle for transcriptional complex formation, we hypothesised that the c-Fos/c-Jun complex may represent a thermodynamic summit in the evolutionary space. Read More

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http://dx.doi.org/10.1002/1873-3468.13388DOI Listing

Upregulation of LGMNP1 confers radiotherapy resistance in glioblastoma.

Oncol Rep 2019 Apr 18. Epub 2019 Apr 18.

Department of Neurosurgery, Shanghai Pudong Hospital, Fudan University, Pudong, Shanghai 200120, P.R. China.

Glioblastoma is a lethal brain tumor type, which is frequently resistant to radiotherapy. The aim of the present study was to explore the function of legumain pseudogene 1 (LGMNP1) on radioresistance in glioblastoma. Reverse transcription‑quantitative PCR was used to detect the relative expression of LGMNP1 in glioma cell lines after radiotherapy. Read More

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http://dx.doi.org/10.3892/or.2019.7128DOI Listing

Shedding Light on the Intrinsic Characteristics of 3D Distorted Fluorite-Type Zirconium Tellurite Single Crystals.

Inorg Chem 2019 Apr 19. Epub 2019 Apr 19.

State Key Laboratory of Crystal Materials , Shandong University , Jinan , Shandong 250100 , People's Republic of China.

Transition-metal tellurites have motivated growing research interest in both fundamental and applied chemistry, and the corresponding single crystals could serve as rich and fascinating platforms to regulate, explore, and elucidate the intrinsic characteristics of different structures from 0D to 3D architectures. In this context, a zirconium tellurite (namely, ZrTeO) single crystal featuring a 3D distorted fluorite-type structure with a size of 35 × 32 × 21 mm was successfully harvested by the top-seeded solution growth (TSSG) technique. The X-ray diffraction rocking curve reflects that the crystallinity of the as-grown ZrTeO crystal is quite perfect with a small full-width at half-maximum (fwhm) value (∼39 arcsec). Read More

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http://dx.doi.org/10.1021/acs.inorgchem.9b00424DOI Listing

Work, Stress and Play: Students' perceptions of factors impacting on their studies and wellbeing.

Eur J Dent Educ 2019 Apr 19. Epub 2019 Apr 19.

DCT 1 Special Care Dental Services, Buckinghamshire Priority Dental Service, Eaglestone Health Centre, Standing Way, Milton Keynes, MK6 5AZ.

Introduction: This study gathered information about life outside of the course for undergraduates studying at the School of Dentistry, Cardiff University. The aim was to explore how these external factors to the course may affect an individual's academic performance and well-being.

Materials And Methods: A cross-sectional study design was used. Read More

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http://dx.doi.org/10.1111/eje.12436DOI Listing

Highly expressed microRNA-940 promotes early abortion by regulating placenta implantation by targeting ZNF672.

Eur Rev Med Pharmacol Sci 2019 Apr;23(7):2693-2700

Department of Obstetrics, Xinchang People Hospital, Xinchang, China.

Objective: Our study aims to explore whether microRNA-940 could participate in early abortion by inhibiting placenta implantation and its underlying mechanism.

Patients And Methods: Expressions of microRNA-940 and ZNF672 in the placental villi of 6 early abortion pregnancies and 6 normal pregnancies were detected by quantitative Real Time-Polymerase Chain Reaction (qRT-PCR). Expressions of microRNA-940 and ZNF672 in trophoblast cells (BeWo, JEG3, Wish and HTR-8) were also detected. Read More

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http://www.europeanreview.org/article/17539
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http://dx.doi.org/10.26355/eurrev_201904_17539DOI Listing
April 2019
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Lycopene protects myocardial ischemia injury through anti-apoptosis and anti-oxidative stress.

Eur Rev Med Pharmacol Sci 2019 Apr;23(7):3096-3104

Department of Pharmacy, Emergency General Hospital, Beijing, China.

Objective: The aim of this research was to explore the protective effect of lycopene (Lyc) on myocardial ischemia injury through anti-apoptosis and anti-oxidative stress.

Materials And Methods: 75 rats were divided into 5 groups: sham operation group (control group), model group, low-dose group (Lyc+2 mg/kg), medium-dose group (Lyc+4 mg/kg) and high-dose group (Lyc+6 mg/kg). The rat model of myocardial ischemia was established by a subcutaneous injection of isoproterenol (85 mg/kg) for two consecutive days. Read More

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http://www.europeanreview.org/article/17593
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http://dx.doi.org/10.26355/eurrev_201904_17593DOI Listing
April 2019
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MiR-92a contributes to the cardiovascular disease development in diabetes mellitus through NF-κB and downstream inflammatory pathways.

Eur Rev Med Pharmacol Sci 2019 Apr;23(7):3070-3079

International Medical Center, Tianjin First Central Hospital, Tianjin, China.

Objective: To explore the role of microRNA-92a (miR-92a) during the development of cardiovascular disease (CAD) in diabetes mellitus (DM) patients, and to investigate its correlation with NF-κB and downstream inflammatory cytokines in diabetes mellitus-associated cardiovascular disease (DM-CAD).

Patients And Methods: Expression of miR-92a in DM and DM-CAD patients was estimated by quantitative Real Time-Polymerase Chain Reaction (qRT-PCR). Receiver operating characteristic (ROC) analysis was used to estimate the capability of miR-92a to discriminate between DM-CAD and DM patients. Read More

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http://dx.doi.org/10.26355/eurrev_201904_17589DOI Listing

MiR-181b regulates atherosclerotic inflammation and vascular endothelial function through Notch1 signaling pathway.

Eur Rev Med Pharmacol Sci 2019 Apr;23(7):3051-3057

Department of Cadre Health Protection, Liaocheng People's Hospital, Liaocheng, China.

Objective: To explore the influences of micro ribonucleic acid (miR)-181b on the inflammation and vascular endothelial function in atherosclerosis (AS), and its specific molecular regulatory mechanism.

Materials And Methods: 44 apolipoprotein E (ApoE)-/- 7 weeks old male rats were randomly divided into normal diet group (NC group) and AS model group (high-fat diet feeding). Rat aorta was dissected and the serum sample was collected in both groups. Read More

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http://dx.doi.org/10.26355/eurrev_201904_17587DOI Listing

IL-10 inhibits apoptosis in brain tissue around the hematoma after ICH by inhibiting proNGF.

Eur Rev Med Pharmacol Sci 2019 Apr;23(7):3005-3011

Department of Geratology, Yantai Yuhuangding Hospital, Yantai, China.

Objective: To explore the roles of interleukin-10 (IL-10), proNGF and p75NTR in apoptosis of brain tissues induced by intracerebral hemorrhage (ICH).

Patients And Methods: According to the time of sample collection after ICH, brain tissue samples were divided into < 6 h group, 6-24 h group (including 24 h), 24-72 h group (including 72 h) and > 72 h group. Meanwhile, 10 tissues that dropped from the beginning at the cortical stoma (distal part of the hematoma) were harvested as controls. Read More

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http://www.europeanreview.org/article/17582
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http://dx.doi.org/10.26355/eurrev_201904_17582DOI Listing
April 2019
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Correlation analysis of TLR9 and IL-23 expression in patients with lupus nephritis.

Eur Rev Med Pharmacol Sci 2019 Apr;23(7):2944-2949

Department of Rheumatology and Immunology, Affiliated Hospital of Jining Medical College, Jining, China.

Objective: The aim of this study was to investigate the expression levels of toll-like receptor 9 (TLR9) and interleukin-23 (IL-23) in renal tissue and serum of patients with lupus nephritis (LN), and to explore their clinical correlation.

Patients And Methods: LN patients and healthy controls were enrolled in the experimental group and the control group, respectively. Blood samples, serum, and peripheral blood mononuclear cells (PBMCs) were collected. Read More

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http://www.europeanreview.org/article/17574
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http://dx.doi.org/10.26355/eurrev_201904_17574DOI Listing
April 2019
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Overexpression of miR-770 indicates a favorable prognosis and suppresses tumorigenesis by modulating PI3K-AKT pathway in glioma.

Eur Rev Med Pharmacol Sci 2019 Apr;23(7):2870-2879

Department of Neurosurgery, The Second Hospital of Shanxi Medical University, Taiyuan, Shanxi, China.

Objective: Previous studies showed that miR-770 expression was deregulated in many tumors. However, the effect of miR-770 function on glioma remains as a mystery. The present study aimed to explore its expression, cellular function and clinic features in glioma. Read More

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http://dx.doi.org/10.26355/eurrev_201904_17565DOI Listing

MiR-506 suppresses papillary thyroid carcinoma cell proliferation and metastasis via targeting IL17RD.

Eur Rev Med Pharmacol Sci 2019 Apr;23(7):2856-2862

Department of Surgical Oncology, Taizhou Municipal Hospital, Taizhou, China.

Objective: The aim of this study was to determine the role of microRNA-506-3p (miR-506) in papillary thyroid carcinoma (PTC), and to further explore the underlying mechanism.

Patients And Methods: The expression level of miR-506 in clinical cases was detected by Real Time-fluorescence quantitative Polymerase Chain Reaction (RT-qPCR). Meanwhile, RT-qPCR was performed to determine miR-506 expression in different PTC cell lines. Read More

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http://www.europeanreview.org/article/17563
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http://dx.doi.org/10.26355/eurrev_201904_17563DOI Listing
April 2019
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MiR-98-5p regulates proliferation and metastasis of MCF-7 breast cancer cells by targeting Gab2.

Eur Rev Med Pharmacol Sci 2019 Apr;23(7):2847-2855

Department of Acupuncture, Taizhou Hospital Affiliated to Nanjing University of Chinese Medicine, Taizhou, China.

Objective: The aim of this study was to explore the mechanism of miR-98-5p in influencing the malignant proliferation and metastasis capacities of breast cancer cells.

Patients And Methods: Quantitative Reverse Transcription-Polymerase Chain Reaction (qRT-PCR) was used to detect the expression level of miR-98-5p and GRB2-associated-binding protein 2 (Gab2) in breast cancer samples and cells. On-line target gene prediction software and Dual-Luciferase reporter assay were used to predict and verify the target genes of miR-98-5p, respectively. Read More

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http://www.europeanreview.org/article/17562
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http://dx.doi.org/10.26355/eurrev_201904_17562DOI Listing
April 2019
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LncRNA MAFG-AS1 promotes the aggressiveness of breast carcinoma through regulating miR-339-5p/MMP15.

Eur Rev Med Pharmacol Sci 2019 Apr;23(7):2838-2846

Department of Obstetrics and Gynecology, Shandong Jiyang Public Hospital, Ji'nan, Shandong, China.

Objective: The main purposes of this study are to investigate the possible effects of long noncoding RNAs (lncRNAs) MAFG-AS1 on the growth and metastasis of breast carcinoma.

Patients And Methods: The quantitative Real Time-Polymerase Chain Reaction (qRT-PCR) assay was used to assess the MAFG-AS1 level in breast cancer tissues and cells. The wound healing and transwell invasion analysis were applied to explore the invasion and migration of breast cancer cell in vitro. Read More

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http://dx.doi.org/10.26355/eurrev_201904_17561DOI Listing

CircRNA ZNF609 promotes growth and metastasis of nasopharyngeal carcinoma by competing with microRNA-150-5p.

Eur Rev Med Pharmacol Sci 2019 Apr;23(7):2817-2826

Department of Otolaryngology Head and Neck Surgery, the Affiliated Hospital of Southwest Medical University, Luzhou, China.

Objective: This study aims to explore the biological function of circular RNA ZNF609 (circ-ZNF609) in regulating the occurrence and progression of nasopharyngeal carcinoma (NPC), and to investigate the possible underlying mechanism.

Patients And Methods: The expression levels of circ-ZNF609, microRNA-150-5p and Sp1 in NPC tissues and normal nasopharyngeal epithelial tissues were detected by quantitative Real Time-Polymerase Chain Reaction (qRT-PCR). Circ-ZNF609 expression was silenced in NPC cell lines (5-8F and HONE-1). Read More

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http://dx.doi.org/10.26355/eurrev_201904_17558DOI Listing

HCP5 promotes colon cancer development by activating AP1G1 via PI3K/AKT pathway.

Eur Rev Med Pharmacol Sci 2019 Apr;23(7):2786-2793

Department of Radiotherapy, Harbin Medical University Cancer Hospital, Harbin, China.

Objective: To explore whether HCP5 participates in the pathogenic progression of colon cancer (CC) and its underlying mechanism.

Patients And Methods: HCP5 expression in CC tissues and cell lines was detected by quantitative Real Time-Polymerase Chain Reaction (qRT-PCR). The correlation between the HCP5 expression and tumor stage of CC patients was then analyzed. Read More

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http://dx.doi.org/10.26355/eurrev_201904_17553DOI Listing

SGK2 promotes renal cancer progression via enhancing ERK 1/2 and AKT phosphorylation.

Eur Rev Med Pharmacol Sci 2019 Apr;23(7):2756-2767

Department of Urology, the First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.

Objective: Increasing studies reported that the serum- and glucocorticoid-inducible kinases (SGKs) contributed to the tumorigenesis of various cancer. In this article, we are aiming to explore the function of SGK2 in renal cell cancer (RCC).

Patients And Methods: In this study, the SGK2 expression was quantified by Western blot (WB) in multiple RCC cell lines. Read More

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http://www.europeanreview.org/article/17549
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http://dx.doi.org/10.26355/eurrev_201904_17549DOI Listing
April 2019
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MicroRNA-448 inhibits the regeneration of spinal cord injury through PI3K/AKT/Bcl-2 axis.

Eur Rev Med Pharmacol Sci 2019 Apr;23(7):2719-2726

Department of Spine Surgery, Jining No. 1 People's Hospital, Jining, China.

Objective: This study aims to elucidate the potential role of microRNA-448 in the recovery of spinal cord injury (SCI), and to explore the underlying mechanism.

Materials And Methods: MicroRNA-448 expression was determined by microarray and the established SCI model in mice. The target gene of microRNA-448 was predicted using bioinformatics. Read More

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http://www.europeanreview.org/article/17543
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http://dx.doi.org/10.26355/eurrev_201904_17543DOI Listing
April 2019
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MiR-543-3p promotes locomotor function recovery after spinal cord injury by inhibiting the expression of tumor necrosis factor superfamily member 15 in rats.

Eur Rev Med Pharmacol Sci 2019 Apr;23(7):2701-2709

Department of Spine Surgery, Jining No. 1 People's Hospital, Jining, China.

Objective: To explore the effect of miR-543-3p on the recovery of locomotor function after spinal cord injury (SCI) by regulating tumor necrosis factor superfamily member 15 (TNFSF15) mediated inflammation and apoptosis.

Materials And Methods: Macrophages were isolated from the abdominal cavity of 2-3 months old Sprague-Dawley (SD) rats and cultured. The levels of miR-543-3p, tumor necrosis factor superfamily member 15 (TNFSF15), TNF-like molecule 1A (TL1A) and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) after transfection of miR-92b-5p into activated macrophages were detected by quantitative Real-time polymerase chain reaction (qRT-PCR). Read More

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http://dx.doi.org/10.26355/eurrev_201904_17540DOI Listing

Fine scale genomic signals of admixture and alien introgression among Asian rice landraces.

Genome Biol Evol 2019 Apr 19. Epub 2019 Apr 19.

UMR AGAP, CIRAD, F-34398 Montpellier, France.

Modern rice cultivars are adapted to a range of environmental conditions and human preferences. At the root of this diversity is a marked genetic structure, owing to multiple foundation events. Admixture and recurrent introgression from wild sources have played upon this base to produce the myriad adaptations existing today. Read More

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https://academic.oup.com/gbe/advance-article/doi/10.1093/gbe
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http://dx.doi.org/10.1093/gbe/evz084DOI Listing
April 2019
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Correlation Analysis Between Stride Characteristics and Racing Ability of 2-year-old Yili Horses in Track Conditions.

J Equine Vet Sci 2019 Apr 30;75:19-24. Epub 2018 Dec 30.

College of Animal Science, Xinjiang Agricultural University, Urumqi, China. Electronic address:

In this study, we aimed to explore correlations among stride characteristics, time records, and bonus amounts to identify relevant indices for evaluating racing abilities of 2-year-old Yili horses. In total, 41 and 26 Yili horses were enrolled in the 1600 and 3600 m races, respectively. This experiment was performed by measuring their stride characteristics using a high-speed video and collecting time records during the competition and the bonus amounts. Read More

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http://dx.doi.org/10.1016/j.jevs.2018.12.022DOI Listing

Investigating associations between pain and complicated grief symptoms in bereaved Japanese older adults.

Aging Ment Health 2019 Apr 19:1-7. Epub 2019 Apr 19.

a Brookdale Center for Healthy Aging , Hunter College of the City University of New York , New York , New York , USA.

Objectives: About 10% of those who lose a loved one in hospice or palliative care settings will experience a mental health condition characterized by severe, prolonged grief responses. Criteria for this condition have evolved; we refer to this condition as Complicated Grief (CG) because it is one of the more common names. While there are some indications of associations between CG and poor physical health, explorations of the association between CG and pain is limited. Read More

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http://dx.doi.org/10.1080/13607863.2019.1594166DOI Listing

Patients' experience regarding therapeutic person-centered relationships in physiotherapy services: A qualitative study.

Physiother Theory Pract 2019 Apr 19:1-11. Epub 2019 Apr 19.

f Nursing and Physical Therapy Department, Health Sciences School , Universidad de León , Ponferrada , León , Spain.

Introduction: Person-centered care has emerged as a key principle in the provision of health and rehabilitation services. To implement this approach, health professionals must strive to develop a person-centered therapeutic relationship. The aim of this study was to explore the barriers and facilitators for the establishment of a person-centered relationship, based on the experience of physiotherapy patients. Read More

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http://dx.doi.org/10.1080/09593985.2019.1603258DOI Listing

Chrysin Inhibits Proinflammatory Factor-Induced EMT Phenotype and Cancer Stem Cell-Like Features in HeLa Cells by Blocking the NF-κB/Twist Axis.

Cell Physiol Biochem 2019 ;52(5):1236-1250

Department of Gynecology and Obstetrics, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China,

Background/aims: TNF-α and TGF-β associated epithelial-mesenchymal transition (EMT) occurs via NF-κB-dependent transcriptional upregulation of Twist1.Chrysin (ChR) is a major active ingredient ofpropolis, which inhibits various cancer cells and possesses anti-inflammatory activities. This study aimed to assess whether and how ChR inhibits proinflammatory cytokine-induced EMT phenotype and cancer stem-like cell (CSLC) features in the HeLa cell line. Read More

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http://dx.doi.org/10.33594/000000084DOI Listing
January 2019