4,406 results match your criteria EEG in Status Epilepticus


Subacute Encephalopathy With Seizures in Alcoholics Syndrome: A Subtype of Nonconvulsive Status Epilepticus.

Epilepsy Curr 2019 Mar-Apr;19(2):77-82

4 Department of Neurology, Johns Hopkins University School of Medicine, Johns Hopkins Bayview Medical Center, Baltimore, MD, USA.

A recent assessment of the classification of nonconvulsive status epilepticus (NCSE) has incorporated the specific electroencephalographic (EEG) patterns on a syndromic basis. Such a clinical EEG syndromic approach may enable more accurate and expedited diagnosis of particular subtypes of NCSE so as to improve therapy. Herein, we review the characteristics of subacute encephalopathy with seizures in alcoholics syndrome, a subtype of focal NCSE occurring in chronic alcoholism with specific features, including encephalopathy, lateralized periodic discharges on the EEG, chronic microvascular ischemia on neuroimaging studies, and possible recurrence when chronic antiseizure treatment is stopped. Read More

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http://dx.doi.org/10.1177/1535759719835676DOI Listing
April 2019
2 Reads

Epilepsy in patients with EAST syndrome caused by mutation in the KCNJ10.

Brain Dev 2019 Apr 2. Epub 2019 Apr 2.

Genetic and Metabolic Department, King Fahad Specialist Hospital, Dammam, Saudi Arabia.

Objective: EAST syndrome comprises of epilepsy, ataxia, sensorineural deafness, and tubulopathy. It is caused by a mutation in KCNJ10 gene. Less than thirty cases have been reported in the literature with emphasis on genetic mutation and renal tubulopathy. Read More

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http://dx.doi.org/10.1016/j.braindev.2019.03.009DOI Listing
April 2019
2 Reads

Role of Epileptic Activity in Older Adults With Delirium, a Prospective Continuous EEG Study.

Front Neurol 2019 19;10:263. Epub 2019 Mar 19.

Neurology Department, ULB-Hôpital Erasme, Université Libre de Bruxelles (ULB), Brussels, Belgium.

Delirium occurs in up to 50 % of hospitalized old patients and is associated with increased morbidity and mortality. Acute medical conditions favor delirium, but the pathophysiology is unclear. Preliminary evidence from retrospective and prospective studies suggests that a substantial minority of old patients with unexplained delirium have non-convulsive seizures or status epilepticus (NCSE). Read More

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http://dx.doi.org/10.3389/fneur.2019.00263DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434717PMC
March 2019
3 Reads

Inducible nitric oxide synthase inhibitor, 1400W, mitigates DFP-induced long-term neurotoxicity in the rat model.

Neurobiol Dis 2019 Mar 30. Epub 2019 Mar 30.

Department of Biomedical Sciences, College of Veterinary Medicine, Iowa State University, Ames, IA 50011, United States. Electronic address:

Chemical nerve agents (CNA) are increasingly becoming a threat to both civilians and military personnel. CNA-induced acute effects on the nervous system have been known for some time and the long-term consequences are beginning to emerge. In this study, we used diisopropylfluorophosphate (DFP), a seizurogenic CNA to investigate the long-term impact of its acute exposure on the brain and its mitigation by an inducible nitric oxide synthase (iNOS) inhibitor, 1400W as a neuroprotectant in the rat model. Read More

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http://dx.doi.org/10.1016/j.nbd.2019.03.031DOI Listing
March 2019
2 Reads
5.078 Impact Factor

Prevalence of electrographic seizure in dogs and cats undergoing electroencephalography and clinical characteristics and outcome for dogs and cats with and without electrographic seizure: 104 cases (2009-2015).

J Am Vet Med Assoc 2019 Apr;254(8):967-973

Objective: To determine the prevalence of electrographic seizure (ES) and electrographic status epilepticus (ESE) in dogs and cats that underwent electroencephalography (EEG) because of suspected seizure activity and to characterize the clinical characteristics, risk factors, and in-hospital mortality rates for dogs and cats with ES or ESE.

Design: Retrospective case series.

Animals: 89 dogs and 15 cats. Read More

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http://dx.doi.org/10.2460/javma.254.8.967DOI Listing
April 2019
3 Reads

Epilepsy Emergencies: Status Epilepticus, Acute Repetitive Seizures, and Autoimmune Encephalitis.

Continuum (Minneap Minn) 2019 04;25(2):454-476

Purpose Of Review: This article reviews epilepsy emergencies, including status epilepticus, acute repetitive seizures, autoimmune encephalitis, and the current perspective on their diagnosis and treatment.

Recent Findings: Recent guidelines on the treatment of status epilepticus from the Neurocritical Care Society in 2012 and the American Epilepsy Society in 2016 highlight areas of consensus in the treatment of status epilepticus as well as areas of uncertainty. The TRENdS (Treatment of Recurrent Electrographic Nonconvulsive Seizures) trial is the first prospective randomized clinical trial to evaluate the efficacy of IV antiseizure medications in controlling nonconvulsive seizures on continuous EEG. Read More

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http://dx.doi.org/10.1212/CON.0000000000000716DOI Listing
April 2019
1 Read

Electroencephalography in Epilepsy Evaluation.

Continuum (Minneap Minn) 2019 04;25(2):431-453

Purpose Of Review: Epilepsy is a heterogeneous disorder that is often associated with abnormal electroencephalogram (EEG) findings. This article provides an overview of common EEG findings in epileptic disorders. The physiologic basis of EEG and intracranial EEG studies is also discussed. Read More

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http://dx.doi.org/10.1212/CON.0000000000000705DOI Listing
April 2019
3 Reads

Non convulsive status epilepticus in the elderly.

Authors:
Sophie Dupont

Geriatr Psychol Neuropsychiatr Vieil 2019 Mar;17(S1):25-30

Epilepsy Unit, Hôpital de la Pitié-Salpêtrière, AP-HP, Paris, France, Rehabilitation Unit, Hôpital de la Pitié-Salpêtrière, AP-HP, Paris, France, Centre de recherche de l'Institut du cerveau et de la moelle épinière (ICM), UMPC-UMR 7225 CNRS-UMRS 975 Inserm, Paris, France, Université Paris Sorbonne, France.

Non-convulsive status epilepticus (NCSE) is common in the elderly. It most often corresponds to prolonged focal seizures with impaired contact ("complex partial status epilepticus"). A form of de novo absence status epilepticus, much rarer, can also meet. Read More

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http://dx.doi.org/10.1684/pnv.2019.0782DOI Listing
March 2019
1 Read

Early seizures after ischemic stroke: focus on thrombolysis.

CNS Spectr 2019 Mar 27:1-13. Epub 2019 Mar 27.

Department of Neurology, Medical School,University of Pecs,Pécs,Hungary.

Introduction: Stroke is a significant underlying cause of epilepsy. Seizures due to ischemic stroke (IS) are generally categorized into early seizures (ESs) and late seizures (LSs). Seizures in thrombolysis situations may raise the possibility of other etiology than IS. Read More

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http://dx.doi.org/10.1017/S1092852919000804DOI Listing
March 2019
3 Reads

Cefepime-Induced Encephalopathy and Nonconvulsive Status Epilepticus: Dispelling an Artificial Dichotomy.

Neurohospitalist 2019 Apr 15;9(2):100-104. Epub 2018 Oct 15.

Department of Neurology, Duke University Medical Center, Durham, NC, USA.

Cefepime is a fourth-generation cephalosporin antibiotic known to have neurotoxic side effects. Recent reports have described patients on cefepime presenting with altered mentation and concurrent triphasic wave discharges on electroencephalogram (EEG). Some have described this clinical presentation as cefepime-induced encephalopathy, while others have termed it as cefepime-induced nonconvulsive status epilepticus (NCSE). Read More

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http://dx.doi.org/10.1177/1941874418803225DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429673PMC

Transition from status epilepticus to interictal spiking in a rodent model of mesial temporal epilepsy.

Epilepsy Res 2019 05 11;152:73-76. Epub 2019 Mar 11.

Montreal Neurological Institute and Departments of Neurology & Neurosurgery, and of Physiology, McGill University, 3801 University Street, Montréal, H3A 2B4, QC, Canada. Electronic address:

Status epilepticus (SE) is a serious, life-threatening condition requiring immediate care to prevent neuronal injury and long-term functional deficits. SE is modeled in rodents by systemic injection of chemoconvulsants such as pilocarpine, which induces EEG and behavioral activities similar to what seen in humans. Combined injection of diazepam and ketamine is commonly used to terminate SE in rodents but, to date, no study has analysed the EEG activity and behavior during SE and after diazepam + ketamine administration. Read More

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http://dx.doi.org/10.1016/j.eplepsyres.2019.03.005DOI Listing
May 2019
1 Read

WIN 55,212-2 Reverted Pilocarpine-Induced Status Epilepticus Early Changes of the Interaction among 5-HT/NMDA/CB Receptors in the Rat Hippocampus.

ACS Chem Neurosci 2019 Mar 26. Epub 2019 Mar 26.

Laboratory of Neurophysiology, Department of Physiology and Biochemistry, Faculty of Medicine and Surgery , University of Malta , Msida MSD 2080 , Malta.

The molecular basis for temporal lobe epileptogenesis  remains poorly defined. Recent evidence shows that serotonin 2C receptors (5-HTRs), NR2A and NR2B subunit-containing N-methyl-d-aspartate receptors (NMDARs) and cannabinoid 1 receptors (CBRs) may be involved in the progression of the epileptic disorders. Moreover, CBR activation has been reported to modulate the activity of 5-HT and NMDA receptors. Read More

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http://dx.doi.org/10.1021/acschemneuro.9b00080DOI Listing
March 2019
1 Read

Persistent behavior deficits, neuroinflammation, and oxidative stress in a rat model of acute organophosphate intoxication.

Neurobiol Dis 2019 Mar 21. Epub 2019 Mar 21.

Department of Molecular Biosciences, School of Veterinary Medicine, University of California-Davis, 1089 Veterinary Medicine Drive, Davis, CA 95616, USA; MIND Institute, School of Medicine, University of California-Davis, 2825 50th Street, Sacramento, CA 95817, USA. Electronic address:

Current medical countermeasures for organophosphate (OP)-induced status epilepticus (SE) are not effective in preventing long-term morbidity and there is an urgent need for improved therapies. Rat models of acute intoxication with the OP, diisopropylfluorophosphate (DFP), are increasingly being used to evaluate therapeutic candidates for efficacy in mitigating the long-term neurologic effects associated with OP-induced SE. Many of these therapeutic candidates target neuroinflammation and oxidative stress because of their implication in the pathogenesis of persistent neurologic deficits associated with OP-induced SE. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09699961193007
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http://dx.doi.org/10.1016/j.nbd.2019.03.019DOI Listing
March 2019
3 Reads

Short burst Clobazam dosing at discharge from VEEG evaluation reduces re-presentation with seizures.

Seizure 2019 Mar 16;67:61-64. Epub 2019 Mar 16.

Mater Advanced Epilepsy Unit, Mater Hospital, Brisbane, Australia.

Purpose: Recurrent seizures and status epilepticus after medication reduction for inpatient Video Electroencephalograph (VEEG) monitoring is a well-known complication of this investigation. In the literature this is reported to occur at a rate of approximately 3-7%. We review the use of short burst Clobazam dosing on discharge from the Epilepsy monitoring unit (EMU) to determine if this might reduce rates of representation with seizures. Read More

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http://dx.doi.org/10.1016/j.seizure.2019.03.008DOI Listing
March 2019
1 Read

Language and behavioral outcomes of treatment with pulse-dose prednisone for electrical status epilepticus in sleep (ESES).

Epilepsy Behav 2019 Mar 18;94:93-99. Epub 2019 Mar 18.

Minnesota Epilepsy Group, P.A., St. Paul, Minnesota, USA; Children's Hospitals and Clinics of Minnesota, St. Paul, Minnesota, USA.

Few studies have examined treatment response in electrical status epilepticus in sleep (ESES), and fewer still have evaluated the effect of corticosteroid treatment employing a pulse-dose regimen. The aim of this study was to examine the effectiveness of pulse-dose prednisone in treating language and behavioral disturbances that often accompany ESES. The sample included 17 patients age 5 to 10 years at time of baseline electroencephalogram (EEG) and neuropsychological assessments. Read More

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http://dx.doi.org/10.1016/j.yebeh.2019.02.016DOI Listing
March 2019
1 Read

Continuous EEG Monitoring in a Consecutive Patient Cohort with Sepsis and Delirium.

Neurocrit Care 2019 Mar 19. Epub 2019 Mar 19.

Department of Clinical Neurophysiology, The Neuroscience Centre, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.

Background: Delirium is common during sepsis, although under-recognized. We aimed to assess the value of continuous electroencephalography (cEEG) to aid in the diagnosis of delirium in septic patients.

Methods: We prospectively evaluated 102 consecutive patients in a medical intensive care unit (ICU), who had sepsis or septic shock, without evidence of acute primary central nervous system disease. Read More

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http://dx.doi.org/10.1007/s12028-019-00703-wDOI Listing
March 2019
7 Reads

Non-convulsive status epilepticus associated with neuronal intranuclear inclusion disease: A case report and literature review.

Epilepsy Behav Case Rep 2019 26;11:103-106. Epub 2019 Jan 26.

Department of Neurology, University of Yamanashi, Yamanashi, Japan.

We report a case of neuronal intranuclear inclusion disease (NIID) confirmed by detection of intranuclear inclusions in a skin biopsy specimen. Brain magnetic resonance imaging showed mild cerebral atrophy and linear hyperintensities at the corticomedullary junction on diffusion-weighted images. This patient developed nonconvulsive status epilepticus with generalized periodic discharges on electroencephalography after recurrent symptoms of paroxysmal nausea and slowly progressive cognitive decline. Read More

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http://dx.doi.org/10.1016/j.ebcr.2019.01.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6403408PMC
January 2019

Incidence, Recurrence, and Risk Factors for Peri-ictal Central Apnea and Sudden Unexpected Death in Epilepsy.

Front Neurol 2019 1;10:166. Epub 2019 Mar 1.

Department of Neurology, University of Texas Health Science Center at Houston, Houston, TX, United States.

Peri-ictal breathing dysfunction was proposed as a potential mechanism for SUDEP. We examined the incidence and risk factors for both ictal (ICA) and post-convulsive central apnea (PCCA) and their relationship with potential seizure severity biomarkers (i. e. Read More

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http://dx.doi.org/10.3389/fneur.2019.00166DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413671PMC
March 2019
1 Read

Continuous Electroencephalogram as a Biomarker of Disease Progression and Severity in Herpes Simplex Virus-1 Encephalitis.

Clin EEG Neurosci 2019 Mar 15:1550059419835705. Epub 2019 Mar 15.

2 Department of Neurology, University of Maryland School of Medicine, Baltimore, MD, USA.

Objective: Herpes simplex virus encephalitis (HSE) is the most common cause of sporadic fatal encephalitis worldwide and remains a devastating disease despite antiviral therapy. EEG can be an important tool in the diagnosis of HSE, and we propose that it can be used to monitor the progression of the disease in patients with treatment refractory HSE.

Methods: This is a case report of a patient with HSE who was monitored on continuous EEG (CEEG) throughout course of her disease. Read More

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http://dx.doi.org/10.1177/1550059419835705DOI Listing
March 2019
4 Reads

Spatiotemporal expression and inhibition of prolyl oligopeptidase contradict its involvement in key pathologic mechanisms of kainic acid-induced temporal lobe epilepsy in rats.

Epilepsia Open 2019 Mar 24;4(1):92-101. Epub 2018 Dec 24.

Laboratory of Experimental Hematology, Vaxinfectio University of Antwerp Antwerp Belgium.

Objective: Prolyl oligopeptidase (PREP) has been implicated in neuroinflammatory processes and neuroplasticity and has been suggested as a target for the treatment of neurodegenerative disease. The aim of this investigation was to explore the involvement of PREP in the neuropathologic mechanisms relevant to temporal lobe epilepsy (TLE) using a PREP inhibitor in a well-established rat model.

Methods: PREP activity and expression was studied in Sprague-Dawley rats 2 and 12 weeks following kainic acid-induced status epilepticus (KASE). Read More

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http://dx.doi.org/10.1002/epi4.12293DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6398098PMC
March 2019
2 Reads

A universal automated tool for reliable detection of seizures in rodent models of acquired and genetic epilepsy.

Epilepsia 2019 Apr 13;60(4):783-791. Epub 2019 Mar 13.

Departments of Neuroscience and Medicine, Central Clinical School, Monash University, Melbourne, Victoria, Australia.

Objective: Prolonged electroencephalographic (EEG) monitoring in chronic epilepsy rodent models has become an important tool in preclinical drug development of new therapies, in particular those for antiepileptogenesis, disease modification, and treating drug-resistant epilepsy. We have developed an easy-to-use, reliable, computational tool for automated detection of electrographic seizures from prolonged EEG recordings in rodent models of epilepsy.

Methods: We applied a novel method based on advanced time-frequency analysis that detects EEG episodes with excessive activity in certain frequency bands. Read More

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http://dx.doi.org/10.1111/epi.14691DOI Listing
April 2019
1 Read

Lateralized periodic discharges in insular status epilepticus: A case report of a periodic EEG pattern associated with ictal manifestation.

Clin Neurophysiol Pract 2019 24;4:27-29. Epub 2019 Jan 24.

Department of Neurology, SS Annunziata Hospital, Chieti, Italy.

Objective: Insular lobe seizures generally represent a misconceived ictal phenomenon characterized by specific neurological signs. Aphasia can be a rare presenting sign associated with insular lobe epilepsy which could be easily mistaken for a manifestation of other acute brain diseases.

Method: We describe an insular status epilepticus (SE) characterized by sudden onset of language disturbance associated with hypersalivation and paraesthesia. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S2467981X193000
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http://dx.doi.org/10.1016/j.cnp.2019.01.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6395825PMC
January 2019
9 Reads

How and Whom to Monitor for Seizures in an ICU: A Systematic Review and Meta-Analysis.

Crit Care Med 2019 Apr;47(4):e366-e373

Section for Clinical Epidemiology and Biostatistics, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Thailand.

Objectives: To pool prevalence of nonconvulsive seizure, nonconvulsive status epilepticus, and epileptiform activity detected by different electroencephalography types in critically ills and to compare detection rates among them.

Data Sources: MEDLINE (via PubMed) and SCOPUS (via Scopus) STUDY SELECTION:: Any type of study was eligible if studies were done in adult critically ill, applied any type of electroencephalography, and reported seizure rates. Case reports and case series were excluded. Read More

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http://Insights.ovid.com/crossref?an=00003246-900000000-9604
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http://dx.doi.org/10.1097/CCM.0000000000003641DOI Listing
April 2019
10 Reads

(-)-Epigallocatechin-3-Gallate Protects Against Lithium-Pilocarpine-Induced Epilepsy by Inhibiting the Toll-Like Receptor 4 (TLR4)/Nuclear Factor-κB (NF-κB) Signaling Pathway.

Med Sci Monit 2019 Mar 7;25:1749-1758. Epub 2019 Mar 7.

Key Laboratory of Neurology of Hebei Province, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, China (mainland).

BACKGROUND Temporal lobe epilepsy (TLE) is the most common type of intractable epilepsy in humans, and it is often accompanied by cognitive impairment. In this study, we examined the effects of (-)-Epigallocatechin-3-gallate (EGCG) after SE on behavior in the rat lithium-pilocarpine model of TLE. MATERIAL AND METHODS The rats were randomly divided into 3 groups: (1) the control group, in which 12 rats received no treatment); (2) the epilepsy (EP) group, in which 15 rats were treated with saline after status epilepticus (SE); and (3) the EP+EGCG group, in which 15 rats were treated with EGCG (25 mg/kg/d, intraperitoneal) after SE. Read More

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http://dx.doi.org/10.12659/MSM.915025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417148PMC
March 2019
9 Reads

Perampanel: A therapeutic alternative in refractory status epilepticus associated with MELAS syndrome.

Epilepsy Behav Case Rep 2019 7;11:92-95. Epub 2019 Feb 7.

Epilepsy Unit, Department of Neurology, Vall d'Hebron University Hospital, Barcelona, Spain.

To our knowledge, there are no reports of status epilepticus (SE) associated with mitochondrial diseases and treated with perampanel (PER). We present three cases of patients with refractory SE associated with MELAS syndrome who responded favorably to PER. All cases were diagnosed as non-convulsive SE (focal without impairment of level of consciousness). Read More

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http://dx.doi.org/10.1016/j.ebcr.2019.01.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6384302PMC
February 2019

Tonic status epilepticus in a centenarian woman.

Epileptic Disord 2019 Feb;21(1):92-96

Department of Neurology, Marqués de Valdecilla University Hospital, Santander, Spain.

Generalized tonic status epilepticus (TSE) is a rare epileptic condition. It occurs usually in the context of symptomatic generalized epilepsy, in particular, in subjects with a diagnosis of Lennox-Gastaut syndrome, atypical forms of idiopathic (genetic) generalized epilepsy, or as a paradoxical effect during treatment with diverse antiepileptic drugs. Herein, we describe the case of an elderly woman on chronic treatment with psychotropic drugs who developed an episode of generalized TSE. Read More

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http://dx.doi.org/10.1684/epd.2019.1031DOI Listing
February 2019
6 Reads

The Different Clinical Features Between Autoimmune and Infectious Status Epilepticus.

Front Neurol 2019 13;10:25. Epub 2019 Feb 13.

Department of Neurology, Kaohsiung Chang Gung Memorial Hospital, College of Medicine, Chang Gung University, Kaohsiung, Taiwan.

The prognosis of status epilepticus (SE) is highly related to the underlying etiology. Inflammation of the central nervous system (CNS), including infection and autoimmune encephalitis, is one of the treatable conditions causing SE. The initial presentation of infectious and autoimmune CNS disorders can be quite similar, which may be difficult to differentiate at the beginning. Read More

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http://dx.doi.org/10.3389/fneur.2019.00025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381771PMC
February 2019
2 Reads

Endosulfan-Induced Prolonged Super-Refractory Status Epilepticus.

J Epilepsy Res 2018 Dec 31;8(2):93-96. Epub 2018 Dec 31.

Department of Neurology, Inje University Ilsan Paik Hospital, Inje University College of Medicine, Goyang, Korea.

Endosulfan is a highly toxic pesticide that causes hyperstimulation of the central nervous system by antagonizing gamma aminobutyric acid-mediated inhibition. Seizure is the most important manifestation of endosulfan poisoning, frequently progressing to status epilepticus and refractory status epilepticus. Here, we report a recent case of a 64-year-old man with endosulfan-induced super-refractory status epilepticus, which persisted for a remarkably longer period than has been described in previous reports. Read More

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http://j-epilepsy.org/journal/view.php?doi=10.14581/jer.1801
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http://dx.doi.org/10.14581/jer.18016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374535PMC
December 2018
5 Reads

Acute Ischemic Stroke Mimicking Non-Convulsive Status Epilepticus.

J Epilepsy Res 2018 Dec 31;8(2):90-92. Epub 2018 Dec 31.

Department of Neurology, Seoul Metropolitan Government Seoul National University Boramae Medical Center, Seoul National University College of Medicine, Seoul, Korea.

Status epilepticus and stroke are occasionally characterized by indistinguishable symptoms. Diffusion-weighted imaging (DWI) could not only help differentiating seizure from stroke, but also assist in localizing a focus of seizure and reflect resolution of seizure. We report a case of non-convulsive status epilepticus that presented as acute ischemic stroke, mimicking the latter's clinical manifestations. Read More

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http://dx.doi.org/10.14581/jer.18015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374534PMC
December 2018

Vagus Nerve Stimulation (VNS) in Super Refractory New Onset Refractory Status Epilepticus (NORSE).

Case Rep Neurol Med 2019 21;2019:7852017. Epub 2019 Jan 21.

Department of Neurocritical Care, Inova Fairfax Hospital, Falls Church, VA, USA.

The treatment protocol of status epilepticus has many associated toxicities so there is interest in alternate nonmedicinal therapies for managing New Onset Refractory Status Epilepticus (NORSE) patients. Vagus nerve stimulation (VNS) is an FDA-approved therapy for refractory epilepsy that has been shown to decrease the frequency and severity of seizures. We present the case of a patient with new-onset refractory status epilepticus (NORSE) whose seizures were successfully treated with vagus nerve stimulation. Read More

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http://dx.doi.org/10.1155/2019/7852017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360559PMC
January 2019
3 Reads

In vivo measurement of brain network connectivity reflects progression and intrinsic disease severity in a model of temporal lobe epilepsy.

Neurobiol Dis 2019 Feb 21;127:45-52. Epub 2019 Feb 21.

Laboratory of Experimental Hematology, University of Antwerp, Belgium. Electronic address:

Different types of brain injury, such as status epilepticus (SE), trauma, or stroke may initiate the process of epileptogenesis and lead to the development of temporal lobe epilepsy. Epileptogenesis is characterized by an initial latent period during which impaired network communication and synaptic circuit alterations are occurring. Ultimately, these modifications result in the development of spontaneous recurrent seizures (SRS). Read More

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http://dx.doi.org/10.1016/j.nbd.2019.02.012DOI Listing
February 2019

Validating a model of benzodiazepine refractory nerve agent-induced status epilepticus by evaluating the anticonvulsant and neuroprotective effects of scopolamine, memantine, and phenobarbital.

J Pharmacol Toxicol Methods 2019 Feb 19;97:1-12. Epub 2019 Feb 19.

Neuroscience Branch, Nerve Agent Countermeasures, U.S. Army Medical Research Institute of Chemical Defense, MD, USA. Electronic address:

Introduction: Organophosphorus nerve agents (OPNAs) irreversibly block acetylcholinesterase activity, resulting in accumulation of excess acetylcholine at neural synapses, which can lead to a state of prolonged seizures known as status epilepticus (SE). Benzodiazepines, the current standard of care for SE, become less effective as latency to treatment increases. In a mass civilian OPNA exposure, concurrent trauma and limited resources would likely cause a delay in first response time. Read More

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http://dx.doi.org/10.1016/j.vascn.2019.02.006DOI Listing
February 2019
4 Reads

Probable sporadic Creutzfeldt-Jakob disease mimicking focal epilepsy.

Epilepsy Behav Case Rep 2019 26;11:77-80. Epub 2019 Jan 26.

Division of Neurology, Department of Internal Medicine, National Yang-Ming University Hospital, No.169, Siaoshe Rd., Yilan City, Yilan County 26058, Taiwan.

Creutzfeldt-Jakob disease (CJD) presents with seizures as an early symptom in only approximately 3% of cases. These seizures often present as nonconvulsive status epilepticus (NCSE) or epilepsia partialis continua (EPC). Here, we describe a case of probable sporadic CJD (sCJD) in an 83-year-old man whose manifest an unusual presentation of left-hand tonic seizures without evolution to EPC, as well as brain MRI findings interpreted as peri-ictal changes, which led to an initial misdiagnosis of focal epilepsy. Read More

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http://dx.doi.org/10.1016/j.ebcr.2019.01.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369248PMC
January 2019
4 Reads

[Continuous spike-waves during slow-wave sleep: Experience during 20 years].

An Pediatr (Barc) 2019 Feb 13. Epub 2019 Feb 13.

Sección de Neuropediatría, Hospital Materno Infantil Gregorio Marañón, Madrid, España.

Introduction: Continuous spikes and waves during slow sleep (CSWS) is an EEG pattern that appears during childhood, and is often associated with cognitive impairment. It can appear in the course of epileptic syndromes, as well as in benign epilepsy. The aim of this study is to analyse epidemiological and clinical characteristic of patients with CSWS, in order to describe possible predictive factors in their outcome. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S16954033193002
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http://dx.doi.org/10.1016/j.anpedi.2018.12.016DOI Listing
February 2019
12 Reads

Functional brain connectivity in electrical status epilepticus in sleep.

Epileptic Disord 2019 Feb;21(1):55-64

Department of Neurological Sciences, Larner College of Medicine, University of Vermont, Burlington, Vermont, USA.

Electrical status epilepticus in sleep (ESES) is an age-related, self-limited epileptic encephalopathy. The syndrome is characterized by cognitive and behavioral abnormalities and a specific EEG pattern of continuous spikes and waves during slow-wave sleep. While spikes and sharp waves are known to result in transient cognitive impairment during learning and memory tasks performed during the waking state, the effect of epileptiform discharges during sleep on cognition and behavior is unclear. Read More

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http://dx.doi.org/10.1684/epd.2019.1027DOI Listing
February 2019
3 Reads

Clinical, Electroencephalographic Features and Prognostic Factors of Cefepime-Induced Neurotoxicity: A Retrospective Study.

Neurocrit Care 2019 Feb 12. Epub 2019 Feb 12.

Section of Epilepsy, Department of Neurology, Chang Gung Memorial Hospital at Linkou Medical Center and Chang Gung University College of Medicine, 5 Fuxing St., Guishan Dist., Taoyuan, 333, Taiwan.

Background: The incidence of cefepime-induced neurotoxicity (CIN) has been previously underestimated, and there have only been sporadic reports from critical neurological settings. The present study aimed to investigate the potential factors associated with disease development, electroencephalography (EEG) sub-classification, and outcome measures.

Methods: The 10-year medical records of patients who underwent EEG between 2007 and 2016 at a tertiary medical center in Taiwan, and developed encephalopathy after cefepime therapy were retrospectively reviewed. Read More

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http://dx.doi.org/10.1007/s12028-019-00682-yDOI Listing
February 2019
1 Read
2.440 Impact Factor

Effects of High- and Low-Frequency Stimulation of the Thalamic Reticular Nucleus on Pentylentetrazole-Induced Seizures in Rats.

Neuromodulation 2019 Feb 11. Epub 2019 Feb 11.

Laboratorio de Neurofisiología del Control y la Regulación. Dirección de Investigaciones en Neurociencias, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Ciudad de México, Mexico.

Rationale: The use of electrical stimulation therapy to treat epilepsy is currently being studied in experimental animals and patients. Our study was designed to evaluate the effects of electrical stimulation applied in the thalamic reticular nucleus (TRN) on the development of pentylentetrazole-induced seizures.

Materials And Methods: Experiments were performed using male Wistar rats with electrodes stereotaxically implanted in the left TRN. Read More

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http://dx.doi.org/10.1111/ner.12926DOI Listing
February 2019
2 Reads

Agomelatine alleviates neuronal loss through BDNF signaling in the post-status epilepticus model induced by kainic acid in rat.

Brain Res Bull 2019 Apr 7;147:22-35. Epub 2019 Feb 7.

Institute of Information and Communication Technologies, BAS, Sofia, Bulgaria.

Recently, we have reported that while agomelatine (Ago) is unable to prevent development of epilepsy it exerts a strong neuroprotective and anti-inflammatory response in the KA post-status epilepticus (SE) rat model. In the present study, we aimed to explore whether the brain-derived neurotrophic factor (BDNF) in the hippocampus is involved in the neuroprotective effect of Ago against the KA-induced SE and epileptiform activity four months later in rats. Lacosamide (LCM) was used as a positive control. Read More

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http://dx.doi.org/10.1016/j.brainresbull.2019.01.017DOI Listing
April 2019
2 Reads

Status epilepticus after C-4 ingestion: using liquid chromatography to quantify toxicity.

Clin Toxicol (Phila) 2019 Feb 7:1-3. Epub 2019 Feb 7.

c Department of Neurology , William Beaumont Army Medical Center , El Paso , TX , USA.

Context: C-4, a commonly used explosive in military operations, is sometimes consumed by soldiers as a rite of passage. The primary component of C-4 is cyclotrimethylenetrinitramine, or Research Department Explosive (RDX), which causes euphoria along with nausea, vomiting, renal injury, encephalopathy and convulsions when consumed in toxic amounts. We present a case of status epilepticus caused by known ingestion of C-4, in which serum levels of the compound were measured with high-performance liquid chromatography (HPLC). Read More

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http://dx.doi.org/10.1080/15563650.2018.1562069DOI Listing
February 2019
4 Reads

Synergistic action of CB and 5-HT receptors in preventing pilocarpine-induced status epilepticus in rats.

Neurobiol Dis 2019 May 1;125:135-145. Epub 2019 Feb 1.

Laboratory of Neurophysiology, Department of Physiology and Biochemistry, Faculty of Medicine and Surgery, University of Malta, Msida, Malta; School of Biosciences, Cardiff University, Cardiff, UK. Electronic address:

Endocannabinoids (eCBs) and serotonin (5-HT) play a neuromodulatory role in the central nervous system. Both eCBs and 5-HT regulate neuronal excitability and their pharmacological potentiation has been shown to control seizures in pre-clinical and human studies. Compelling evidence indicates that eCB and 5-HT systems interact to modulate several physiological and pathological brain functions, such as food intake, pain, drug addiction, depression, and anxiety. Read More

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http://dx.doi.org/10.1016/j.nbd.2019.01.026DOI Listing
May 2019
4 Reads

Adult-onset Rasmussen's Syndrome with associated cortical dysplasia.

Epilepsy Behav Case Rep 2019 28;11:54-57. Epub 2018 Nov 28.

Department of Neurosurgery, UT Health San Antonio, San Antonio, TX, United States of America.

We describe a 23-year-old woman with previous right temporal lobe surgeries for underlying cortical dysplasia, presenting with right hemispheric seizures and epilepsia partialis continua (EPC). After anti-seizure medication adjustments, she developed focal status epilepticus with progressive EEG and neuroimaging changes. Cerebrospinal fluid and serum autoimmune panels were negative except for an elevated serum acetylcholine-receptor antibody titer, but she underwent immunosuppressive therapy. Read More

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http://dx.doi.org/10.1016/j.ebcr.2018.11.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6349012PMC
November 2018
11 Reads

[Subcortical calcification on CT in Borden type III intracranial dural arteriovenous fistula].

Rinsho Shinkeigaku 2019 Feb 31;59(2):93-97. Epub 2019 Jan 31.

Department of Neurology, Nissan Tamagawa Hospital.

We herein report a 67-year-old female who presented with progressive dementia and disturbance of consciousness. Brain CT showed multiple subcortical calcifications with edema. Enhanced CT showed multiple abnormal vessels in the left hemisphere. Read More

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http://dx.doi.org/10.5692/clinicalneurol.cn-001200DOI Listing
February 2019
6 Reads

[Rhythmic and periodic EEG patterns. Classification and clinical significance.]

Zh Nevrol Psikhiatr Im S S Korsakova 2018;118(10. Vyp. 2):9-20

Evdokimov Moscow State University of Medical Dentistry, Moscow, Russia; Sklifosovsky Research Institute of Emergency Medicine, Moscow, Russia.

The review presents the methodology of electroencephalography (EEG) background analysis, sporadic epileptiform discharges classification, and description of the rhythmic and periodic patterns in patients with primary and secondary brain damage. It describes the process of decision making in starting non-convulsive status epilepticus treatment of patients with EEG-verified non-convulsive status epilepticus and the signs of 'malignant' patterns indicating the irreversibility of brain injury. Read More

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http://dx.doi.org/10.17116/jnevro20181181029DOI Listing
January 2018
1 Read

Clinical and EEG Characteristics of Ifosfamide-Related Encephalopathy.

J Clin Neurophysiol 2019 Mar;36(2):150-154

Department of Neurology, Memorial Sloan Kettering Cancer Center, New York, New York, U.S.A.

Purpose: Ifosfamide can lead to a syndrome of central nervous system toxicity. Here, we investigate the clinical and EEG characteristics of patients with ifosfamide-related encephalopathy.

Methods: Retrospective data were collected on patients from Memorial Sloan Kettering Cancer Center, who developed encephalopathy associated with ifosfamide between 2007 and 2017. Read More

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http://Insights.ovid.com/crossref?an=00004691-900000000-9948
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http://dx.doi.org/10.1097/WNP.0000000000000539DOI Listing
March 2019
7 Reads

Baclofen Neurotoxicity: A Metabolic Encephalopathy Susceptible to Exacerbation by Benzodiazepine Therapy.

J Clin Neurophysiol 2019 Jan 24. Epub 2019 Jan 24.

Department of Neurology, Royal Perth Hospital, Perth, Australia.

Purpose: Baclofen has been reported to cause both a metabolic encephalopathy and nonconvulsive status epilepticus. Baclofen is typically used in the management of muscle spasticity but is being increasingly used to manage alcohol withdrawal and opiate dependency. Given the increasing use of baclofen we describe the clinical and electrographical features of baclofen neurotoxicity seen at our institution. Read More

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http://dx.doi.org/10.1097/WNP.0000000000000565DOI Listing
January 2019
3 Reads

Use of Continuous EEG Monitoring in Children Presenting With Encephalopathy Following Convulsive Status Epilepticus.

J Clin Neurophysiol 2019 Jan 24. Epub 2019 Jan 24.

Division of Neurology, Carman and Ann Adams Department of Pediatrics, Children's Hospital of Michigan, Detroit, Michigan, U.S.A.

Purpose: The Critical Care Continuous EEG Task Force of the American Clinical Neurophysiology Society recommends continuous EEG (cEEG) monitoring in patients with persistent encephalopathy following convulsive status epilepticus. This recommendation is based on data, which correlates prolonged nonconvulsive seizures and nonconvulsive status epilepticus with worse neurologic outcomes. Compliance with these recommendations may be limited by barriers such as inadequate resource and staff availability. Read More

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http://dx.doi.org/10.1097/WNP.0000000000000566DOI Listing
January 2019
7 Reads

Serious central nervous system side effects of cephalosporins: A national analysis of serious reports registered in the French Pharmacovigilance Database.

J Neurol Sci 2019 Mar 16;398:196-201. Epub 2019 Jan 16.

Centre Régional de Pharmacovigilance, Service de Pharmacologie Clinique et Pharmacovigilance, APHM, INSERM, Inst Neurosci Syst, Aix Marseille Univ, Marseille, France. Electronic address:

Introduction: Among antibiotics, Central Nervous System (CNS) adverse drug reactions (ADRs) are often under-suspected and overlooked. Cephalosporins are an important cause of drug-induced CNS ADRs but the characteristics of such ADR have not been fully explored. We aimed to characterize the profile of cephalosporins serious CNS ADRs. Read More

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http://dx.doi.org/10.1016/j.jns.2019.01.018DOI Listing
March 2019
2 Reads

Comparing the efficacy of sodium valproate and levetiracetam following initial lorazepam in elderly patients with generalized convulsive status epilepticus (GCSE): A prospective randomized controlled pilot study.

Seizure 2019 Feb 15;65:111-117. Epub 2019 Jan 15.

Department of Neurology, National Institute of Mental Health and NeuroSciences (NIMHANS), Bangalore, India. Electronic address:

Purpose: This randomized control study was conducted to compare the efficacy of sodium valproate (SVP) and levetiracetam (LEV) following initial intravenous lorazepam in elderly patients (age: >60years) with generalized convulsive status epilepticus (GCSE) and to identify predictors of poor seizure control.

Methods: A total of 118 patients (mean age: 67.5 ± 7. Read More

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http://dx.doi.org/10.1016/j.seizure.2019.01.015DOI Listing
February 2019
4 Reads