4,355 results match your criteria EEG in Status Epilepticus


Validating a model of benzodiazepine refractory nerve agent-induced status epilepticus by evaluating the anticonvulsant and neuroprotective effects of scopolamine, memantine, and phenobarbital.

J Pharmacol Toxicol Methods 2019 Feb 18. Epub 2019 Feb 18.

Neuroscience Branch, Nerve Agent Countermeasures, U.S. Army Medical Research Institute of Chemical Defense, MD, USA. Electronic address:

Introduction: Organophosphorus nerve agents (OPNAs) irreversibly block acetylcholinesterase activity, resulting in accumulation of excess acetylcholine at neural synapses, which can lead to a state of prolonged seizures known as status epilepticus (SE). Benzodiazepines, the current standard of care for SE, become less effective as latency to treatment increases. In a mass civilian OPNA exposure, concurrent trauma and limited resources would likely cause a delay in first response time. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.vascn.2019.02.006DOI Listing
February 2019

Probable sporadic Creutzfeldt-Jakob disease mimicking focal epilepsy.

Epilepsy Behav Case Rep 2019 26;11:77-80. Epub 2019 Jan 26.

Division of Neurology, Department of Internal Medicine, National Yang-Ming University Hospital, No.169, Siaoshe Rd., Yilan City, Yilan County 26058, Taiwan.

Creutzfeldt-Jakob disease (CJD) presents with seizures as an early symptom in only approximately 3% of cases. These seizures often present as nonconvulsive status epilepticus (NCSE) or epilepsia partialis continua (EPC). Here, we describe a case of probable sporadic CJD (sCJD) in an 83-year-old man whose manifest an unusual presentation of left-hand tonic seizures without evolution to EPC, as well as brain MRI findings interpreted as peri-ictal changes, which led to an initial misdiagnosis of focal epilepsy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ebcr.2019.01.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369248PMC
January 2019

[Continuous spike-waves during slow-wave sleep: Experience during 20 years].

An Pediatr (Barc) 2019 Feb 13. Epub 2019 Feb 13.

Sección de Neuropediatría, Hospital Materno Infantil Gregorio Marañón, Madrid, España.

Introduction: Continuous spikes and waves during slow sleep (CSWS) is an EEG pattern that appears during childhood, and is often associated with cognitive impairment. It can appear in the course of epileptic syndromes, as well as in benign epilepsy. The aim of this study is to analyse epidemiological and clinical characteristic of patients with CSWS, in order to describe possible predictive factors in their outcome. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S16954033193002
Publisher Site
http://dx.doi.org/10.1016/j.anpedi.2018.12.016DOI Listing
February 2019
1 Read

Functional brain connectivity in electrical status epilepticus in sleep.

Epileptic Disord 2019 Feb 15. Epub 2019 Feb 15.

Department of Neurological Sciences, Larner College of Medicine, University of Vermont, Burlington, Vermont, USA.

Electrical status epilepticus in sleep (ESES) is an age-related, self-limited epileptic encephalopathy. The syndrome is characterized by cognitive and behavioral abnormalities and a specific EEG pattern of continuous spikes and waves during slow-wave sleep. While spikes and sharp waves are known to result in transient cognitive impairment during learning and memory tasks performed during the waking state, the effect of epileptiform discharges during sleep on cognition and behavior is unclear. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1684/epd.2019.1027DOI Listing
February 2019

Clinical, Electroencephalographic Features and Prognostic Factors of Cefepime-Induced Neurotoxicity: A Retrospective Study.

Neurocrit Care 2019 Feb 12. Epub 2019 Feb 12.

Section of Epilepsy, Department of Neurology, Chang Gung Memorial Hospital at Linkou Medical Center and Chang Gung University College of Medicine, 5 Fuxing St., Guishan Dist., Taoyuan, 333, Taiwan.

Background: The incidence of cefepime-induced neurotoxicity (CIN) has been previously underestimated, and there have only been sporadic reports from critical neurological settings. The present study aimed to investigate the potential factors associated with disease development, electroencephalography (EEG) sub-classification, and outcome measures.

Methods: The 10-year medical records of patients who underwent EEG between 2007 and 2016 at a tertiary medical center in Taiwan, and developed encephalopathy after cefepime therapy were retrospectively reviewed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12028-019-00682-yDOI Listing
February 2019
1 Read

Effects of High- and Low-Frequency Stimulation of the Thalamic Reticular Nucleus on Pentylentetrazole-Induced Seizures in Rats.

Neuromodulation 2019 Feb 11. Epub 2019 Feb 11.

Laboratorio de Neurofisiología del Control y la Regulación. Dirección de Investigaciones en Neurociencias, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Ciudad de México, Mexico.

Rationale: The use of electrical stimulation therapy to treat epilepsy is currently being studied in experimental animals and patients. Our study was designed to evaluate the effects of electrical stimulation applied in the thalamic reticular nucleus (TRN) on the development of pentylentetrazole-induced seizures.

Materials And Methods: Experiments were performed using male Wistar rats with electrodes stereotaxically implanted in the left TRN. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/ner.12926DOI Listing
February 2019
1 Read

Agomelatine alleviates neuronal loss through BDNF signaling in the post-status epilepticus model induced by kainic acid in rat.

Brain Res Bull 2019 Feb 7;147:22-35. Epub 2019 Feb 7.

Institute of Information and Communication Technologies, BAS, Sofia, Bulgaria.

Recently, we have reported that while agomelatine (Ago) is unable to prevent development of epilepsy it exerts a strong neuroprotective and anti-inflammatory response in the KA post-status epilepticus (SE) rat model. In the present study, we aimed to explore whether the brain-derived neurotrophic factor (BDNF) in the hippocampus is involved in the neuroprotective effect of Ago against the KA-induced SE and epileptiform activity four months later in rats. Lacosamide (LCM) was used as a positive control. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.brainresbull.2019.01.017DOI Listing
February 2019
1 Read

Status epilepticus after C-4 ingestion: using liquid chromatography to quantify toxicity.

Clin Toxicol (Phila) 2019 Feb 7:1-3. Epub 2019 Feb 7.

c Department of Neurology , William Beaumont Army Medical Center , El Paso , TX , USA.

Context: C-4, a commonly used explosive in military operations, is sometimes consumed by soldiers as a rite of passage. The primary component of C-4 is cyclotrimethylenetrinitramine, or Research Department Explosive (RDX), which causes euphoria along with nausea, vomiting, renal injury, encephalopathy and convulsions when consumed in toxic amounts. We present a case of status epilepticus caused by known ingestion of C-4, in which serum levels of the compound were measured with high-performance liquid chromatography (HPLC). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/15563650.2018.1562069DOI Listing
February 2019
2 Reads

Synergistic action of CB and 5-HT receptors in preventing pilocarpine-induced status epilepticus in rats.

Neurobiol Dis 2019 Feb 1;125:135-145. Epub 2019 Feb 1.

Laboratory of Neurophysiology, Department of Physiology and Biochemistry, Faculty of Medicine and Surgery, University of Malta, Msida, Malta; School of Biosciences, Cardiff University, Cardiff, UK. Electronic address:

Endocannabinoids (eCBs) and serotonin (5-HT) play a neuromodulatory role in the central nervous system. Both eCBs and 5-HT regulate neuronal excitability and their pharmacological potentiation has been shown to control seizures in pre-clinical and human studies. Compelling evidence indicates that eCB and 5-HT systems interact to modulate several physiological and pathological brain functions, such as food intake, pain, drug addiction, depression, and anxiety. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.nbd.2019.01.026DOI Listing
February 2019
2 Reads

Adult-onset Rasmussen's Syndrome with associated cortical dysplasia.

Epilepsy Behav Case Rep 2019 28;11:54-57. Epub 2018 Nov 28.

Department of Neurosurgery, UT Health San Antonio, San Antonio, TX, United States of America.

We describe a 23-year-old woman with previous right temporal lobe surgeries for underlying cortical dysplasia, presenting with right hemispheric seizures and epilepsia partialis continua (EPC). After anti-seizure medication adjustments, she developed focal status epilepticus with progressive EEG and neuroimaging changes. Cerebrospinal fluid and serum autoimmune panels were negative except for an elevated serum acetylcholine-receptor antibody titer, but she underwent immunosuppressive therapy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ebcr.2018.11.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6349012PMC
November 2018
5 Reads

[Subcortical calcification on CT in Borden type III intracranial dural arteriovenous fistula].

Rinsho Shinkeigaku 2019 Jan 31. Epub 2019 Jan 31.

Department of Neurology, Nissan Tamagawa Hospital.

We herein report a 67-year-old female who presented with progressive dementia and disturbance of consciousness. Brain CT showed multiple subcortical calcifications with edema. Enhanced CT showed multiple abnormal vessels in the left hemisphere. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5692/clinicalneurol.cn-001200DOI Listing
January 2019
2 Reads

[Rhythmic and periodic EEG patterns. Classification and clinical significance.]

Zh Nevrol Psikhiatr Im S S Korsakova 2018 ;118(10. Vyp. 2):9-20

Evdokimov Moscow State University of Medical Dentistry, Moscow, Russia; Sklifosovsky Research Institute of Emergency Medicine, Moscow, Russia.

The review presents the methodology of electroencephalography (EEG) background analysis, sporadic epileptiform discharges classification, and description of the rhythmic and periodic patterns in patients with primary and secondary brain damage. It describes the process of decision making in starting non-convulsive status epilepticus treatment of patients with EEG-verified non-convulsive status epilepticus and the signs of 'malignant' patterns indicating the irreversibility of brain injury. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.17116/jnevro20181181029DOI Listing
January 2018
1 Read

Clinical and EEG Characteristics of Ifosfamide-Related Encephalopathy.

J Clin Neurophysiol 2019 Jan 30. Epub 2019 Jan 30.

Department of Neurology, Memorial Sloan Kettering Cancer Center, New York, New York, U.S.A.

Purpose: Ifosfamide can lead to a syndrome of central nervous system toxicity. Here, we investigate the clinical and EEG characteristics of patients with ifosfamide-related encephalopathy.

Methods: Retrospective data were collected on patients from Memorial Sloan Kettering Cancer Center, who developed encephalopathy associated with ifosfamide between 2007 and 2017. Read More

View Article

Download full-text PDF

Source
http://Insights.ovid.com/crossref?an=00004691-900000000-9948
Publisher Site
http://dx.doi.org/10.1097/WNP.0000000000000539DOI Listing
January 2019
1 Read

Baclofen Neurotoxicity: A Metabolic Encephalopathy Susceptible to Exacerbation by Benzodiazepine Therapy.

J Clin Neurophysiol 2019 Jan 24. Epub 2019 Jan 24.

Department of Neurology, Royal Perth Hospital, Perth, Australia.

Purpose: Baclofen has been reported to cause both a metabolic encephalopathy and nonconvulsive status epilepticus. Baclofen is typically used in the management of muscle spasticity but is being increasingly used to manage alcohol withdrawal and opiate dependency. Given the increasing use of baclofen we describe the clinical and electrographical features of baclofen neurotoxicity seen at our institution. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/WNP.0000000000000565DOI Listing
January 2019
2 Reads

Use of Continuous EEG Monitoring in Children Presenting With Encephalopathy Following Convulsive Status Epilepticus.

J Clin Neurophysiol 2019 Jan 24. Epub 2019 Jan 24.

Division of Neurology, Carman and Ann Adams Department of Pediatrics, Children's Hospital of Michigan, Detroit, Michigan, U.S.A.

Purpose: The Critical Care Continuous EEG Task Force of the American Clinical Neurophysiology Society recommends continuous EEG (cEEG) monitoring in patients with persistent encephalopathy following convulsive status epilepticus. This recommendation is based on data, which correlates prolonged nonconvulsive seizures and nonconvulsive status epilepticus with worse neurologic outcomes. Compliance with these recommendations may be limited by barriers such as inadequate resource and staff availability. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/WNP.0000000000000566DOI Listing
January 2019
2 Reads

Serious central nervous system side effects of cephalosporins: A national analysis of serious reports registered in the French Pharmacovigilance Database.

J Neurol Sci 2019 Jan 16. Epub 2019 Jan 16.

Centre Régional de Pharmacovigilance, Service de Pharmacologie Clinique et Pharmacovigilance, APHM, INSERM, Inst Neurosci Syst, Aix Marseille Univ, Marseille, France. Electronic address:

Introduction: Among antibiotics, Central Nervous System (CNS) adverse drug reactions (ADRs) are often under-suspected and overlooked. Cephalosporins are an important cause of drug-induced CNS ADRs but the characteristics of such ADR have not been fully explored. We aimed to characterize the profile of cephalosporins serious CNS ADRs. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jns.2019.01.018DOI Listing
January 2019
2 Reads

FDG-PET and MRI in the Evolution of New-Onset Refractory Status Epilepticus.

AJNR Am J Neuroradiol 2019 Feb 24;40(2):238-244. Epub 2019 Jan 24.

Department of Nuclear Medicine (G.W., M.L.).

Background And Purpose: New-onset refractory status epilepticus is a clinical condition characterized by acute and prolonged pharmacoresistant seizures without a pre-existing relevant neurologic disorder, prior epilepsy, or clear structural, toxic, or metabolic cause. New-onset refractory status epilepticus is often associated with antineuronal antibodies and may respond to early immunosuppressive therapy, reflecting an inflammatory element of the condition. FDG-PET is a useful diagnostic tool in inflammatory and noninflammatory encephalitis. Read More

View Article

Download full-text PDF

Source
http://www.ajnr.org/lookup/doi/10.3174/ajnr.A5929
Publisher Site
http://dx.doi.org/10.3174/ajnr.A5929DOI Listing
February 2019
3 Reads

[Emergency management and medical care of adults with first epileptic seizures].

Dtsch Med Wochenschr 2019 Jan 23;144(2):83-92. Epub 2019 Jan 23.

Suspected epileptic seizures are a frequent cause of emergency hospital care. After single seizures, the emergency management includes safety measures and diagnostic efforts to distinguish epileptic seizures from its manifold mimics and to possibly detect acute causes of epileptic seizures. Convulsive status epilepticus requires rapid anticonvulsant treatment according to established protocols and diagnostics to rule out underlying acute brain diseases. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1055/a-0660-3174DOI Listing
January 2019

Factors affecting epilepsy prognosis in patients with tuberous sclerosis.

Childs Nerv Syst 2019 Mar 23;35(3):463-468. Epub 2019 Jan 23.

Department of Biostatistics, Cukurova University, Adana, Turkey.

Purpose: We aimed to determine the characteristics of epileptic seizures that significantly affect the cognitive functions of 83 patients followed with tuberous sclerosis complex (TSC), their resistance to treatment and risk factors causing this resistance.

Materials-methods: In order to determine the prognosis, the seizure-free/seizure-controlled group and the group with refractory seizures were compared. In addition, risk factors affecting cognitive functions in the patients were determined. Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s00381-019-04066-7
Publisher Site
http://dx.doi.org/10.1007/s00381-019-04066-7DOI Listing
March 2019
3 Reads

Adult neurogenesis in the mouse dentate gyrus protects the hippocampus from neuronal injury following severe seizures.

Hippocampus 2019 Jan 23. Epub 2019 Jan 23.

Center for Dementia Research, The Nathan Kline Institute of Psychiatric Research, Orangeburg, New York.

Previous studies suggest that reducing the numbers of adult-born neurons in the dentate gyrus (DG) of the mouse increases susceptibility to severe continuous seizures (status epilepticus; SE) evoked by systemic injection of the convulsant kainic acid (KA). However, it was not clear if the results would be the same for other ways to induce seizures, or if SE-induced damage would be affected. Therefore, we used pilocarpine, which induces seizures by a different mechanism than KA. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/hipo.23062
Publisher Site
http://dx.doi.org/10.1002/hipo.23062DOI Listing
January 2019
3 Reads
4.162 Impact Factor

Nonconvulsive status epilepticus secondary to acute porphyria crisis.

Epilepsy Behav Case Rep 2019 28;11:43-46. Epub 2018 Nov 28.

Department of Neurology, Mayo Clinic, 5777 East Mayo Boulevard, Phoenix, AZ 85054, USA.

Both variegate and acute intermittent porphyria can manifest with various neurological symptoms. Although acute symptomatic seizures have been previously described, they are typically tonic-clonic and focal impaired awareness seizures. Convulsive status epilepticus and epilepsia partialis continua are rare and have been described on a case report basis. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S22133232183012
Publisher Site
http://dx.doi.org/10.1016/j.ebcr.2018.11.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327909PMC
November 2018
10 Reads

Identification of non-convulsive status epilepticus with bradylalia using arterial spin-labeling magnetic resonance imaging.

Acute Med Surg 2019 Jan 23;6(1):73-77. Epub 2018 Sep 23.

Department of Nuclear Medicine and Radiology Institute of Development, Aging and Cancer Tohoku University Aoba-kuSendai Japan.

Case: Non-convulsive status epilepticus (NCSE) is among the differential diagnoses of decreased consciousness, but often presents a diagnostic challenge. A 65-year-old woman was admitted to our emergency department with bradylalia. No abnormal finding was detected by computed tomography or magnetic resonance imaging. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ams2.369DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6328911PMC
January 2019
4 Reads

Differences in neurodegeneration between kainic acid-injected GAERS and Wistar rats.

Turk Neurosurg 2018 Aug 7. Epub 2018 Aug 7.

Marmara University School of Medicine.

Aim: The aim of this study was to compare neurodegenerative changes, using fluorojade-B staining, following status epilepticus induced by intraamygdaloid injection of kainic acid in Genetic Absence Epileptic Rats from Strasbourg (GAERS) and nonepileptic control Wistar animals.

Material And Methods: Adult male GAERS and Wistar rats received a single unilateral intraamygdaloid kainic acid injection (750 ng) to induce status epilepticus. EEG and behavioral changes were recorded throughout the experiments. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5137/1019-5149.JTN.23019-18.3DOI Listing
August 2018
2 Reads

EEG in WNV Neuroinvasive Disease.

J Clin Neurophysiol 2019 Jan 21. Epub 2019 Jan 21.

Department of Neurology, Mayo Clinic, Scottsdale, AZ, U.S.A.

Purpose: Neuroinvasive West Nile virus (WNV) is rare, occurring in less than 1% of those infected, and may manifest as meningitis, encephalitis, and/or acute flaccid paralysis. Patients may present initially with nonspecific symptoms including fevers. Although rare, neuroinvasive WNV is associated with significant morbidity and mortality. Read More

View Article

Download full-text PDF

Source
http://Insights.ovid.com/crossref?an=00004691-900000000-9948
Publisher Site
http://dx.doi.org/10.1097/WNP.0000000000000558DOI Listing
January 2019
6 Reads

Erratum to "Early Diagnosis of Nonconvulsive Status Epilepticus Recurrence with Raw EEG of a Bispectral Index Monitor".

Authors:
Aristide Ntahe

Case Rep Crit Care 2018 16;2018:7147626. Epub 2018 Dec 16.

Département d'Anesthésie-Réanimation, Hôpital Saint-Louis, Assistance Publique-Hôpitaux de Paris, 1 Avenue Claude Vellefaux, 75010 Paris, France.

[This corrects the article DOI: 10.1155/2018/1208401.]. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1155/2018/7147626DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311314PMC
December 2018

Follow-up of patients with epilepsy harboring antiglycine receptor antibodies.

Epilepsy Behav 2019 Jan 11;92:103-107. Epub 2019 Jan 11.

Department of Neuroscience, Istanbul University, Institute of Experimental Medicine, Istanbul, Turkey.

Objective: The long-term follow-up of patients with epilepsy harboring autoantibodies against the glycine receptor (also glycine receptor antibodies or GlyR-Ab) is not well-known. Our aim was to investigate the 5-year prognosis and treatment response of patients with epilepsy who were seropositive for GlyR-Ab.

Methods: Clinical features; electroencephalogram (EEG), neuroradiological, and neuropathological findings; and treatment responses of patients with epilepsy with GlyR-Ab seropositivity were investigated. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S15255050183060
Publisher Site
http://dx.doi.org/10.1016/j.yebeh.2018.09.034DOI Listing
January 2019
10 Reads

Evaluation of cerebral blood flow in older patients with status epilepticus using arterial spin labeling.

eNeurologicalSci 2019 Mar 17;14:56-59. Epub 2018 Dec 17.

Department of Neurology, Aomori Prefectural Central Hospital, Aomori, Japan.

Introduction: Although older patients with status epilepticus (SE) have a high mortality rate and poor outcome, it is difficult to perform emergent electroencephalography (EEG) to diagnose SE in community hospitals. Arterial spin labeling (ASL) is a non-invasive magnetic resonance imaging (MRI) technique that can rapidly assess cerebral blood flow (CBF). Further, ASL can detect increased CBF in the ictal period. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ensci.2018.12.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6313842PMC

Comparative efficacy of valnoctamide and sec-butylpropylacetamide (SPD) in terminating nerve agent-induced seizures in pediatric rats.

Epilepsia 2019 Feb 7;60(2):315-321. Epub 2019 Jan 7.

Institute for Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel.

Objectives: Children and adults are likely to be among the casualties in a civilian nerve agent exposure. This study evaluated the efficacy of valnoctamide (racemic-VCD), sec-butylpropylacetamide (racemic-SPD), and phenobarbital for stopping nerve agent seizures in both immature and adult rats.

Methods: Female and male postnatal day (PND) 21, 28, and 70 (adult) rats, previously implanted with electroencephalography (EEG) electrodes were exposed to seizure-inducing doses of the nerve agents sarin or VX and EEG was recorded continuously. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/epi.14630DOI Listing
February 2019
3 Reads

EEG analysis in anti-NMDA receptor encephalitis: Description of typical patterns.

Clin Neurophysiol 2019 Feb 29;130(2):289-296. Epub 2018 Nov 29.

Department of Neurology, University Hospital Center of Saint-Etienne, France; NeuroPain Lab, Lyon Neuroscience Research Centre, CRNL-InsermU 1028/CNRS UMR5292, University of Lyon, France. Electronic address:

Objective: To describe different electroencephalogram (EEG) patterns and epileptic features in patients with anti-N-methyl-D-aspartate receptor encephalitis (anti-NMDARE), their timeline in the course of the disease, their correlation with clinical data and outcome.

Methods: We retrospectively analyzed EEG recordings between November 2007 and June 2016 in 24 consecutive patients.

Results: Three EEG patterns were described: Excessive Beta Activity range 14-20 Hz (EBA) in 71% of patients, Extreme Delta Brush (EDB) in 58% and Generalized Rhythmic Delta Activity (GRDA) in 50%. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.clinph.2018.10.017DOI Listing
February 2019
3 Reads

Levodropropizine suppresses seizure activity in rats with pentylenetetrazol-induced epilepsy.

Epilepsy Res 2019 Feb 29;150:32-37. Epub 2018 Dec 29.

Department of Physiology, Faculty of Medicine, Bilim University, Istanbul, Turkey. Electronic address:

Background: Millions of individuals worldwide suffer from epilepsy, and up to 25% of patients have seizures that are resistant to currently available antiepileptic drugs. Hence, there continues to be a need for more seizure medications that are effective yet tolerable. Levodropropizine (LVDP) is an established antitussive drug that, based on preclinical data, may also have antiepileptic activity. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S09201211183039
Publisher Site
http://dx.doi.org/10.1016/j.eplepsyres.2018.12.011DOI Listing
February 2019
4 Reads

Epilepsy in Children: From Diagnosis to Treatment with Focus on Emergency.

J Clin Med 2019 Jan 2;8(1). Epub 2019 Jan 2.

Department of Anesthesiology, AOU Policlinico-Vittorio Emanuele, University of Catania Via S. Sofia, 78, 95123 Catania, Italy.

Seizures are defined as a transient occurrence of signs and symptoms due to the abnormal, excessive, or synchronous neuronal activity in the brain characterized by abrupt and involuntary skeletal muscle activity. An early diagnosis, treatment, and specific medical support must be performed to prevent Status Epilepticus (SE). Seizure onset, especially in the child population, is related to specific risk factors like positive family history, fever, infections, neurological comorbidity, premature birth, mother's alcohol abuse, and smoking in pregnancy. Read More

View Article

Download full-text PDF

Source
http://www.mdpi.com/2077-0383/8/1/39
Publisher Site
http://dx.doi.org/10.3390/jcm8010039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352402PMC
January 2019
8 Reads

Epidemiology-Based Mortality Score is Associated with Long-Term Mortality after Status Epilepticus.

Neurocrit Care 2019 Jan 3. Epub 2019 Jan 3.

Department of Neurology, University Hospital of Odense, Sdr. Boulevard 10, 5000, Odense C, Denmark.

Background/objective: Status epilepticus (SE) is a life-threatening condition with a high long-term mortality. The correct prediction of the individual patient's outcome is crucial for stratifying treatment. Status epilepticus severity score (STESS) and the epidemiology-based mortality score (EMSE) are well established for predicting in-hospital mortality; however, scores indicating long-term mortality are lacking. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12028-018-0663-0DOI Listing
January 2019

Successful use of pure cannabidiol for the treatment of super-refractory status epilepticus.

Epilepsy Behav Case Rep 2018 17;10:141-144. Epub 2018 Jul 17.

Department of Pediatrics (Division of Neurology), David Geffen School of Medicine and UCLA Mattel Children's Hospital, Los Angeles, CA, USA.

We present the case of a child with long-standing, super-refractory status epilepticus (SRSE) who manifested prompt and complete resolution of SRSE upon exposure to pure cannabidiol. SRSE emerged in the context of remote suspected encephalitis with previously well-controlled epilepsy. We discuss the extent to which response may be specifically attributed to cannabidiol, with consideration and discussion of multiple potential drug-drug interactions. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ebcr.2018.07.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306515PMC
July 2018
1 Read

Generalized Convulsive Status Epilepticus Secondary to Jarisch-Herxheimer Reaction in Neurosyphilis: A Case Report and Literature Review.

Neurologist 2019 Jan;24(1):29-32

Department of Neurology, Health Sciences Center, Federal University of Santa Maria, Rio Grande do Sul, Brazil.

Introduction: Jarisch-Herxheimer reaction (JHR) is defined as a transient immunologic reaction, classically seen in patients during syphilis treatment. JHR is a rare cause of status epilepticus (SE) in neurosyphilis. We describe a case of generalized convulsive SE (GCSE) probably secondary to JHR in a patient with neurosyphilis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/NRL.0000000000000219DOI Listing
January 2019
2 Reads

Nonconvulsive Status Epilepticus: Validating the Salzburg Criteria Against an Expert EEG Examiner.

J Clin Neurophysiol 2018 Dec 21. Epub 2018 Dec 21.

Department of Neurology, Odense University Hospital, Odense, Denmark.

Purpose: Rapid and correct diagnosis of nonconvulsive status epilepticus (NCSE) is crucial for optimal treatment. However, electroencephalographic diagnosis can be challenging. Salzburg Consensus Criteria (SCC) have been proposed to facilitate correct diagnosis, but their validity needs to be further established. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/WNP.0000000000000556DOI Listing
December 2018

[Etiology and clinical features of epilepsia partialis continua: an analysis of six cases].

Zhongguo Dang Dai Er Ke Za Zhi 2018 Dec;20(12):1008-1014

Department of Emergency, Xiangya Hospital, Central South University, Changsha 410008, China.

Objective: To investigate the etiology and clinical features of epilepsia partialis continua (EPC) in children.

Methods: A retrospective analysis was performed for the clinical features, diagnosis and treatment of six children with EPC, and the clinical and laboratory features and prognosis were compared between the children with different etiologies.

Results: There were five girls and one boy, with an onset age ranging from one year and seven months to nine years. Read More

View Article

Download full-text PDF

Source
December 2018
6 Reads

Human induced pluripotent stem cell-derived MGE cell grafting after status epilepticus attenuates chronic epilepsy and comorbidities via synaptic integration.

Proc Natl Acad Sci U S A 2019 01 17;116(1):287-296. Epub 2018 Dec 17.

Institute for Regenerative Medicine, Texas A&M Health Science Center College of Medicine, Temple, TX 76502;

Medial ganglionic eminence (MGE)-like interneuron precursors derived from human induced pluripotent stem cells (hiPSCs) are ideal for developing patient-specific cell therapy in temporal lobe epilepsy (TLE). However, their efficacy for alleviating spontaneous recurrent seizures (SRS) or cognitive, memory, and mood impairments has never been tested in models of TLE. Through comprehensive video- electroencephalographic recordings and a battery of behavioral tests in a rat model, we demonstrate that grafting of hiPSC-derived MGE-like interneuron precursors into the hippocampus after status epilepticus (SE) greatly restrained SRS and alleviated cognitive, memory, and mood dysfunction in the chronic phase of TLE. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1814185115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320542PMC
January 2019
9.809 Impact Factor

The clinical utility of ambulatory EEG in childhood.

Seizure 2019 Jan 29;64:45-49. Epub 2018 Nov 29.

School of Medicine, College of Medical & Veterinary Life Sciences, University of Glasgow, United Kingdom; Paediatric Neurosciences Research Group & EEG Department, Royal Hospital for Children, Glasgow, United Kingdom. Electronic address:

Purpose: To evaluate the clinical utility of the ambulatory electroencephalogram (AEEG) in children.

Method: Data from 199 consecutive referrals for a paediatric AEEG were reviewed retrospectively. Information was gathered on various aspects of the referral process, the characteristics of the children referred and the reasons for referral. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S10591311183058
Publisher Site
http://dx.doi.org/10.1016/j.seizure.2018.11.020DOI Listing
January 2019
8 Reads

Acute non-convulsive status epilepticus after experimental traumatic brain injury in rats.

J Neurotrauma 2018 Dec 13. Epub 2018 Dec 13.

University of Eastern Finalnd , Neulaniementie 2 , Kuopio, Finland , 70211 ;

Severe traumatic brain injury (TBI) induces seizures or status epilepticus (SE) in 20%-30% of patients during the acute phase. We hypothesized that severe TBI induced with lateral fluid-percussion injury (FPI) triggers post-impact SE. Adult Sprague-Dawley male rats were anesthetized with isoflurane and randomized into sham-operated experimental control or lateral FPI-induced severe TBI groups. Read More

View Article

Download full-text PDF

Source
https://www.liebertpub.com/doi/10.1089/neu.2018.6107
Publisher Site
http://dx.doi.org/10.1089/neu.2018.6107DOI Listing
December 2018
2 Reads

New-Onset Geriatric Epilepsy in China: A Single-Center Study.

Chin Med J (Engl) 2018 Dec;131(24):2915-2920

Department of Neurology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.

Background: Few studies have been published on new-onset geriatric epilepsy especially in older Chinese people. This study was to have a comprehensive understanding of new-onset geriatric epilepsy and find a more reasonable diagnosis and management of epilepsy in older people.

Methods: One hundred and three patients with onset age 60 years and older were admitted between January 2008 and December 2016. Read More

View Article

Download full-text PDF

Source
http://www.cmj.org/text.asp?2018/131/24/2915/247194
Publisher Site
http://dx.doi.org/10.4103/0366-6999.247194DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6302641PMC
December 2018
11 Reads

De novo absence status epilepticus in three paediatric patients: a new idiopathic epilepsy syndrome?

Epileptic Disord 2018 Dec;20(6):502-507

Hospital de Pediatría "La madre y el Niño", Formosa, Argentina.

Absence status epilepticus (ASE) is a prolonged generalized absence seizure that usually lasts for hours and can even last for days. The main symptom is the altered content of consciousness while the patient may be alert and partly responsive. We describe the electroclinical features, treatment, and evolution of three paediatric patients with de novo ASE with an excellent response to valproic acid (VPA). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1684/epd.2018.1008DOI Listing
December 2018
2 Reads

KCNQ2 mutation in an infant with encephalopathy of infancy with migrating focal seizures.

Epileptic Disord 2018 Dec;20(6):541-544

Department of Pediatrics (Neurology), McMaster University, 1280 Main St., W. Hamilton, Ontario L8S 4K1, Canada.

A male neonate presented with seizures at 18 hours of life, characterized by tonic posturing with eye deviation to the right, apnoea, bradycardia, and oxygen desaturation. Initial structural, metabolic, and infectious work-up was unremarkable. He continued to have seizures refractory to a variety of antiepileptic medications. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1684/epd.2018.1011DOI Listing
December 2018
1 Read

Juvenile absence epilepsy relapsing as recurrent absence status, mimicking transient global amnesia, in an elderly patient.

Epileptic Disord 2018 Dec;20(6):557-561

IRCCS Institute of Neurological Sciences, Bologna, Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy.

We describe a 68-year-old woman who had typical absence seizures since 14 years of age. The absences were refractory to treatment and persisted into adulthood, with no seizure-free periods until seizure control at 59 years of age. After six years of being seizure-free, she presented with an episode characterized by mental confusion, abnormal behaviour, and amnesia, lasting for several hours. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1684/epd.2018.1016DOI Listing
December 2018

Nonconvulsive Seizure Detection by Reduced-Lead Electroencephalography in Children with Altered Mental Status in the Emergency Department.

J Pediatr 2018 Dec 7. Epub 2018 Dec 7.

Department of Pediatrics, Kobe University Graduate School of Medicine, Kobe, Japan.

Objectives: To evaluate the proportion of children presenting to the emergency department (ED) with altered mental status who demonstrate nonconvulsive seizures on reduced-lead electroencephalography (EEG), and to further investigate the characteristics, treatment, and outcomes in these patients compared with patients without nonconvulsive seizures.

Study Design: In this retrospective cohort study, we reviewed the database and medical records of pediatric patients (aged <18 years) in a single ED between May 1, 2016, and April 30, 2018. We first determined the proportion of nonconvulsive seizures among patients with altered mental status (Glasgow Coma Scale <15). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jpeds.2018.11.019DOI Listing
December 2018
1 Read

Conventional and quantitative EEG in status epilepticus.

Seizure 2018 Oct 6. Epub 2018 Oct 6.

Departments of Neurology and Pediatrics, The Children's Hospital of Philadelphia and the University of Pennsylvania; 3501 Civic Center Blvd. Philadelphia, PA, 19104.

Purpose: To summarize the use of continuous electroencephalographic monitoring (cEEG) in the diagnosis and management of pediatric convulsive status epilepticus (CSE) and subsequent non-convulsive seizures (NCS) with a focus on available guidelines and infrastructure. In addition, we provide an overview of quantitative EEG (QEEG) for the identification of NCS in critically ill children.

Methods: We performed a review of the medical literature on the use of cEEG and QEEG in pediatric CSE. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.seizure.2018.09.011DOI Listing
October 2018
6 Reads

Pupillary hippus as clinical manifestation of refractory autonomic nonconvulsive status epilepticus: Pathophysiological implications.

Seizure 2018 Dec 15;63:102-104. Epub 2018 Nov 15.

Department of Intensive Medicine, Marqués de Valdecilla University Hospital, Santander, Cantabria, Spain; Department of Biomedical Research Institute (IDIVAL), Santander, Spain.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.seizure.2018.11.006DOI Listing
December 2018
2 Reads

Creutzfeldt-Jakob Disease Presenting as Nonconvulsive Status Epilepticus.

Case Rep Neurol Med 2018 4;2018:3092018. Epub 2018 Nov 4.

Department of Neurology and Neurosurgery, University of Tartu, Estonia.

Creutzfeldt-Jakob disease is a rare, rapidly progressive spongiform encephalopathy in humans. EEG plays an important role in diagnosing this disease. In some patients, epileptic activity and encephalopathy from various aetiologies may share morphological features on EEG. Read More

View Article

Download full-text PDF

Source
https://www.hindawi.com/journals/crinm/2018/3092018/
Publisher Site
http://dx.doi.org/10.1155/2018/3092018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6241237PMC
November 2018
11 Reads

Continuous EEG is associated with favorable hospitalization outcomes for critically ill patients.

Neurology 2019 Jan 30;92(1):e9-e18. Epub 2018 Nov 30.

From the Department of Neurology (C.E.H., L.J.B., D.T., K.A.D., N.D., B.L., A.W.W.), Leonard Davis Institute of Health Economics (C.E.H., N.D., A.W.W.), Translational Center of Excellence for Neurology Outcomes Research, Department of Neurology (D.T., A.W.W.), and Department of Biostatistics, Epidemiology and Informatics (A.W.W.), University of Pennsylvania, Philadelphia.

Objective: To characterize continuous EEG (cEEG) use patterns in the critically ill and to determine the association with hospitalization outcomes for specific diagnoses.

Methods: We performed a retrospective cross-sectional study with National Inpatient Sample data from 2004 to 2013. We sampled hospitalized adult patients who received intensive care and then compared patients who underwent cEEG to those who did not. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1212/WNL.0000000000006689DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6336162PMC
January 2019
1 Read

Status Epilepticus, Refractory Status Epilepticus, and Super-refractory Status Epilepticus.

Continuum (Minneap Minn) 2018 12;24(6):1683-1707

Purpose Of Review: Status epilepticus, refractory status epilepticus, and super-refractory status epilepticus can be life-threatening conditions. This article presents an overview of the three conditions and discusses their management and outcomes.

Recent Findings: Status epilepticus was previously defined as lasting for 30 minutes or longer but now is more often defined as lasting 5 minutes or longer. Read More

View Article

Download full-text PDF

Source
http://Insights.ovid.com/crossref?an=00132979-201812000-0000
Publisher Site
http://dx.doi.org/10.1212/CON.0000000000000668DOI Listing
December 2018
13 Reads