5,018 results match your criteria EEG in Status Epilepticus

Automated Pupillometry for Assessment of Treatment Success in Nonconvulsive Status Epilepticus.

Neurocrit Care 2021 Jul 30. Epub 2021 Jul 30.

Department of Neurology, Klinikum Kassel, Kassel, Germany.

Background: Altered pupillary function may reflect nonconvulsive status epilepticus (NCSE). Neurological pupil index (NPi) assessed by automated pupillometry is a surrogate marker of global pupillary function. We aimed to assess NPi changes in relation to NCSE treatment response. Read More

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The Impacts of Surgery and Intracerebral Electrodes in C57BL/6J Mouse Kainate Model of Epileptogenesis: Seizure Threshold, Proteomics, and Cytokine Profiles.

Front Neurol 2021 12;12:625017. Epub 2021 Jul 12.

Department of Musculoskeletal Biology, Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool, United Kingdom.

Intracranial electroencephalography (EEG) is commonly used to study epileptogenesis and epilepsy in experimental models. Chronic gliosis and neurodegeneration at the injury site are known to be associated with surgically implanted electrodes in both humans and experimental models. Currently, however, there are no reports on the impact of intracerebral electrodes on proteins in the hippocampus and proinflammatory cytokines in the cerebral cortex and plasma in experimental models. Read More

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The Good, the Bad, and the Deadly: Adenosinergic Mechanisms Underlying Sudden Unexpected Death in Epilepsy.

Front Neurosci 2021 12;15:708304. Epub 2021 Jul 12.

Department of Neurosurgery, Robert Wood Johnson Medical School, Rutgers University, Piscataway, NJ, United States.

Adenosine is an inhibitory modulator of neuronal excitability. Neuronal activity results in increased adenosine release, thereby constraining excessive excitation. The exceptionally high neuronal activity of a seizure results in a surge in extracellular adenosine to concentrations many-fold higher than would be observed under normal conditions. Read More

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EEG spindles integrity in critical care adults. Analysis of a randomized trial.

Acta Neurol Scand 2021 Jul 26. Epub 2021 Jul 26.

Department of Clinical Neuroscience, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.

Objectives: Occurrence of EEG spindles has been recently associated with favorable outcome in ICU patients. Available data mostly rely on relatively small patients' samples, particular etiologies, and limited variables ascertainment. We aimed to expand previous findings on a larger dataset, to identify clinical and EEG patterns correlated with spindle occurrence, and explore its prognostic implications. Read More

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Chronic limbic epilepsy models for therapy discovery: Protocols to improve efficiency.

Epilepsia 2021 Jul 21. Epub 2021 Jul 21.

SEIN: Epilepsy Institute in the Netherlands Foundation Heemstede, Heemstede, The Netherlands.

Objective: There have been recommendations to improve therapy discovery for epilepsy by incorporating chronic epilepsy models into the preclinical process, but unpredictable seizures and difficulties in maintaining drug levels over prolonged periods have been obstacles to using these animals. We report new protocols in which drugs are administered through a new chronic gastric tube to rats with higher seizure frequencies to minimize these obstacles.

Methods: Adult rats with spontaneous limbic seizures following an episode of limbic status epilepticus induced by electrical hippocampal stimulation were monitored with long-term video- electroencephalography (EEG). Read More

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Scopolamine prevents aberrant mossy fiber sprouting and facilitates remission of epilepsy after brain injury.

Neurobiol Dis 2021 Jul 16;158:105446. Epub 2021 Jul 16.

Department of Pharmacology, Toxicology, and Pharmacy, University of Veterinary Medicine, Hannover, Germany; Center for Systems Neuroscience, Hannover, Germany. Electronic address:

Prevention or modification of acquired epilepsy in patients at risk is an urgent, yet unmet, clinical need. Following acute brain insults, there is an increased risk of mesial temporal lobe epilepsy (mTLE), which is often associated with debilitating comorbidities and reduced life expectancy. The latent period between brain injury and the onset of epilepsy may offer a therapeutic window for interfering with epileptogenesis. Read More

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Phenotype of heterozygous variants of dehydrodolichol diphosphate synthase.

Dev Med Child Neurol 2021 Jul 18. Epub 2021 Jul 18.

Department of Pediatrics, Peking University First Hospital, Beijing, China.

Aim: To further identify and broaden the phenotypic characteristics and genotype spectrum of the dehydrodolichol diphosphate synthase (DHDDS) gene.

Method: Pathogenic variants of DHDDS were identified by whole-exome sequencing; clinical data of 10 patients (six males, four females; age range 2-14y; mean age 5y 9mo, SD 3y 3mo) were collected and analysed.

Results: All patients had seizures, and myoclonic seizures could be seen in eight patients, with myoclonic status epilepticus in three. Read More

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Risk factors of epilepsy in children with complex febrile seizures; A Retrospective cohort study.

Pediatr Int 2021 Jul 17. Epub 2021 Jul 17.

Neurology Division, Pediatric Department, Chiang Mai University Hospital, Chiang Mai University, Faculty of Medicine.

Background: Febrile seizures are the most common seizures in children. Children with complex febrile seizures have a higher risk of subsequent epilepsy compared with children with simple febrile seizures. Multiple risks factors of epilepsy including focal status epilepticus, family history of epilepsy, neurodevelopmental abnormalities and abnormal EEG findings have been found with inconsistent results. Read More

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Seizures in Children with Cardiac Disease on Extracorporeal Membrane Oxygenation.

Neurocrit Care 2021 Jul 15. Epub 2021 Jul 15.

Division of Pediatric Critical Care Medicine, Department of Pediatrics, Indiana University School of Medicine and Riley Hospital for Children at Indiana University Health, 705 Riley Hospital Drive, Phase 2, Room 4900, Indianapolis, IN, 46202-5225, USA.

Background: Children supported with extracorporeal membrane oxygenation (ECMO) have been shown to be at risk for developing seizures. However, previous studies have consisted of heterogeneous patient populations. We aimed to describe the rate of seizures in pediatric patients receiving ECMO for cardiac indications and to identify risk factors for the occurrence of this complication. Read More

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Efficacy of lacosamide in neonatal-onset super-refractory status epilepticus: a case report.

Epileptic Disord 2021 Aug;23(4):655-660

Paediatric Neurology and Neurophysiology Unit, Department of Woman's and Child's Health, Padova University Hospital, Padova, Italy.

We report the case of a previously healthy newborn who developed super-refractory status epilepticus after Group B streptococcal meningoencephalitis. After administration of first-, second- and third-line anticonvulsants without resolution of status epilepticus, we started intravenous lacosamide as adjunctive therapy to phenobarbital, phenytoin and continuous infusion of ketamine and midazolam. After administration of lacosamide, we observed a clear-cut improvement in the neurological clinical condition coupled with seizure control on continuous video-EEG monitoring, even after suspension of all other medications except for phenobarbital. Read More

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Clinical phenotypes within nonconvulsive status epilepticus.

Epilepsia 2021 Jul 9. Epub 2021 Jul 9.

Neurology Unit, Baggiovara Civil Hospital, AOU Modena, Modena, Italy.

The study aimed to identify distinct phenotypes within nonconvulsive status epilepticus (NCSE). Consecutive episodes of NCSE in patients at least 14 years old were included. The level of consciousness was assessed through the Glasgow Coma Scale (GCS). Read More

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Simulation for Neurology training: Acute setting and beyond.

B Casolla

Rev Neurol (Paris) 2021 Jul 3. Epub 2021 Jul 3.

University Côte d'Azur (UCA), Department of Neurology, Stroke unit, CHU Nice, 06000 Nice, France. Electronic address:

Simulation-based training is adapted for teaching neurology, and it can offer multiple programs for general and specialized neurologists. Indeed, simulation training is "learner-centered", assuring sessions tailored to each learner level, and provides a realistic, safe, controlled and reproducible environment to improve knowledge, technical and non-technical skills, including situational awareness, communication, teamwork and leadership. Indeed, simulation tools allow multidisciplinary sessions with different team members (nurses, physician associates, specialist trainees, technicians) participating with their experiences. Read More

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Processed EEG from depth of anaesthesia monitors and seizures: A scoping review.

Seizure 2021 Jun 17;91:198-206. Epub 2021 Jun 17.

Department of Neurology, North Bristol NHS Trust, UK.

Purpose: Processed electroencephalogram (EEG) is used peri-operatively for monitoring depth of anaesthesia. Because these utilise EEG data, attempts have been made to investigate their use in diagnosing and monitoring seizures. This is important as formal EEG monitoring can be hard to obtain in many critical care environments. Read More

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Corpus callosotomy in pediatric patients with non-lesional epileptic encephalopathy with electrical status epilepticus during sleep.

Epilepsy Behav Rep 2021 8;16:100463. Epub 2021 Jun 8.

Department of Neurosurgery, National Center Hospital, National Center of Neurology and Psychiatry, Kodaira, Tokyo, Japan.

Epileptic encephalopathy with electrical status epilepticus during sleep (ESES) is often refractory to medical treatment and leads to poor cognitive outcomes. Corpus callosotomy may be an effective treatment option for drug-resistant ESES with no focal etiology. We retrospectively identified three patients who underwent corpus callosotomy for drug-resistant ESES in our institution. Read More

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Management of Neurological Emergencies in Children: An Updated Overview.

Neuropediatrics 2021 08 30;52(4):242-251. Epub 2021 Jun 30.

Child Neurology and Infantile Psychiatry Unit, Department of Human Neuroscience, Sapienza Università di Roma, Rome, Italy.

Neurological emergencies account for about one-third of the highest severity codes attributed in emergency pediatric departments. About 75% of children with acute neurological symptoms presents with seizures, headache, or other paroxysmal events. Life-threatening conditions involve a minor proportion of patients (e. Read More

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[Long-term EEG monitoring in patients with acute traumatic brain injury].

Zh Nevrol Psikhiatr Im S S Korsakova 2021 ;121(5):62-67

Sklifosovsky Research Institute of Emergenscy Medicine, Moscow, Russia.

Objective: To investigate the informativeness of long-term scalp EEG monitoring in patients with acute traumatic brain injury (TBI).

Material And Methods: The informativity of long-term EEG monitoring (LTM) was performed in 60 patients with acute severe TBI. Odd ratios (OR) of unfavorable outcome and non-convulsive status epilepticus (NCSE) among clinical, neurophysiological and radiological features were calculated. Read More

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Prospective evaluation of interrater agreement between EEG technologists and neurophysiologists.

Sci Rep 2021 Jun 28;11(1):13406. Epub 2021 Jun 28.

Epilepsy Center Frankfurt Rhine-Main and Department of Neurology, Center of Neurology and Neurosurgery, Goethe-University Frankfurt, Schleusenweg 2-16 (Haus 95), 60528, Frankfurt am Main, Germany.

We aim to prospectively investigate, in a large and heterogeneous population, the electroencephalogram (EEG)-reading performances of EEG technologists. A total of 8 EEG technologists and 5 certified neurophysiologists independently analyzed 20-min EEG recordings. Interrater agreement (IRA) for predefined EEG pattern identification between EEG technologists and neurophysiologits was assessed using percentage of agreement (PA) and Gwet-AC1. Read More

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Epilepsy Associated With Mitochondrial Encephalomyopathy, Lactic Acidosis, and Stroke-Like Episodes.

Front Neurol 2021 11;12:675816. Epub 2021 Jun 11.

Department of Neurology and Neuroscience Center, The First Hospital of Jilin University, Changchun, China.

The present study explored the clinical characteristics and prognostic factors of epilepsy in patients with mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS). Thirty-four MELAS patients were included in the present study. They were diagnosed by clinical characteristics, genetic testing, muscle biopsy, and retrospective analysis of other clinical data. Read More

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Non-Convulsive Status Epileptics Presenting with Periodic Lateralized Epileptiform Discharges and Coma after Cerebral Hemorrhage: A Case Report.

Neurol India 2021 May-Jun;69(3):733-736

Department of Neurology and Neuroscience Center, The First Hospital of Jilin University, Changchun, China.

Background: Non-convulsive status epileptics (NCSE) is a common neurological emergency necessitating rapid assessment and management, but is often underdiagnosed as it lacks specific electroencephalographic features. The diagnostic value of periodic lateralized epileptiform discharges (PLEDs) in NCSE is still unclear. Herein, we reported a case with NCSE manifesting as PLEDs and coma. Read More

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Limbic progesterone receptor activity enhances neuronal excitability and seizures.

Epilepsia 2021 Jun 24. Epub 2021 Jun 24.

Department of Neurology, University of Virginia-HSC, Charlottesville, VA, USA.

Objective: Emerging evidence raises the possibility that progesterone receptor (PR) signaling may contribute to the reproductive hormone fluctuation-linked seizure precipitation, called catamenial epilepsy. Therefore, we studied PR isoform expression in limbic regions involved in temporal lobe epilepsy and the effect of PR activation on neuronal activity and seizures.

Methods: We evaluated PR expression in the limbic regions, entorhinal cortex (EC), hippocampus, and amygdala in female rats using quantitative real-time polymerase chain reaction (qRT-PCR). Read More

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Clinical Electroencephalography Findings and Considerations in Hospitalized Patients With Coronavirus SARS-CoV-2.

Neurohospitalist 2021 Jul 3;11(3):204-213. Epub 2020 Dec 3.

Department of Neurology, Massachusetts General Hospital, Boston, MA, USA.

Background And Purpose: Reports have suggested that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes neurologic manifestations including encephalopathy and seizures. However, there has been relatively limited electrophysiology data to contextualize these specific concerns and to understand their associated clinical factors. Our objective was to identify EEG abnormalities present in patients with SARS-CoV-2, and to determine whether they reflect new or preexisting brain pathology. Read More

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Early and late-onset nonconvulsive status epilepticus after stroke.

Arq Neuropsiquiatr 2021 05;79(5):384-389

Antalya Education and Research Hospital, Department of Neurology, Antalya, Turkey.

Background: Nonconvulsive status epilepticus (NCSE) is a condition that needs timely diagnosis and treatment. It has insignificant clinical features and presents high risk of misdiagnosis.

Objective: To investigate NCSE among patients with stroke, given that stroke plays an important role in the etiology of NCSE. Read More

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Do Triphasic Waves and Nonconvulsive Status Epilepticus Arise From Similar Mechanisms? A Computational Model.

J Clin Neurophysiol 2021 Jun 18. Epub 2021 Jun 18.

Department of Technical Medicine, University of Twente, Enschede, the Netherlands; Department of Applied Mathematics, University of Twente, Enschede, the Netherlands; Northwest University, Xi'an, China; and Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts, U.S.A.

Purpose: Triphasic waves arising in patients with toxic metabolic encephalopathy (TME) are often considered different from generalized periodic discharges (GPDs) in patients with generalized nonconvulsive status epilepticus (GNCSE). The primary objective of this study was to investigate whether a common mechanism can explain key aspects of both triphasic waves in TME and GPDs in GNCSE.

Method: A neural mass model was used for the simulation of EEG patterns in patients with acute hepatic encephalopathy, a common etiology of TME. Read More

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Atypical or Typical Triphasic Waves-Is There a Difference? A Review.

J Clin Neurophysiol 2021 Jun 18. Epub 2021 Jun 18.

Clinical Neurophysiology Department, Marqués de Valdecilla University Hospital, Santander, Cantabria, Spain; Biomedical Research Institute (IDIVAL), Santander, Cantabria, Spain; and Department of Neurology, Johns Hopkins Bayview Medical Center, Baltimore, Maryland, U.S.A.

Summary: The entity of triphasic waves (TWs) and TW encephalopathy has derived from the subjective art of EEG interpretation. Indeed, there are few if any guidelines regarding many different aspects of TWs. The authors seek to shed light on the nature and the diagnostic characteristics of various types of TWs, differentiating "typical" from "atypical" forms. Read More

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Status Triphasicus Versus Status Epilepticus?

J Clin Neurophysiol 2021 Jun 18. Epub 2021 Jun 18.

Department of Neurology, Miller School of Medicine, University of Miami, Miami, Florida, U.S.A.; and Neurology Services, University of Miami Hospital and Clinics and Jackson Memorial Hospital, Miami, Florida, U.S.A.

Summary: Generalized periodic patterns with triphasic wave morphology, long referred to as triphasic waves [TWs], had been associated with metabolic encephalopathies, although other neurologic and systemic causes have since been identified. In a recent classification of periodic patterns, TWs were formally grouped with the generalized periodic discharges, which are often associated with ictal activity. The interpretation of generalized periodic patterns with TWs as nonictal can have significant implications in the management of comatose patients in nonconvulsive status epilepticus. Read More

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Triphasic Waves: Historical Overview of an Unresolved Mystery.

J Clin Neurophysiol 2021 Jun 18. Epub 2021 Jun 18.

Clinical Neurophysiology Department, Marqués de Valdecilla University Hospital, Santander, Cantabria, Spain; Biomedical Research Institute (IDIVAL), Santander, Cantabria, Spain; and Department of Neurology, Johns Hopkins Bayview Medical Center, Baltimore, Maryland, U.S.A.

Summary: Triphasic waves are a fascinating and mysterious EEG feature. We now have to accept that, at times, epileptiform discharges may have a blunted "triphasic morphology," and that there may be great difficulty in distinguishing between these often similar forms. The aim of this review was to describe the evolution in our understanding of triphasic waves that has occurred regarding the pathophysiology of triphasic waves, their most frequent causes, and the diagnostic difficulties involved in interpretation and differentiation from nonconvulsive status epilepticus. Read More

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An Electroencephalographic Voyage in Search of TWs-The Sirens and Corsairs on the Encephalopathy/EEG Horizon: A Survey of TWs.

J Clin Neurophysiol 2021 Jun 18. Epub 2021 Jun 18.

Department of Neurology, Johns Hopkins Bayview Medical Center, Baltimore, Maryland, U.S.A.; Department of Neurology, Epilepsy Unit Montpellier, Montpellier, France; Intensive Care Units and Department of Neurology, University Hospital Basel, Basel, Switzerland; and University of Basel, Basel, Switzerland.

Summary: Generalized periodic discharges with triphasic wave (TW) morphology, long referred to as TWs, are typical of many toxic, metabolic, infectious, and cerebral structural problems, often in concert. Identifying TWs has been challenging for the electroencephalographer and clinician, as has been their cause, significance, prognosis, and treatment. This review highlights the many different patterns of TWs with commentary on their various causes and etiologies, characteristics, different morbidities, differentiation from nonconvulsive status epilepticus, and their prognosis. Read More

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COVID-19: A Potential Cause of Non-convulsive Status Epilepticus.

Cureus 2021 May 15;13(5):e15041. Epub 2021 May 15.

Anesthesia and Critical Care, Cheikh Khalifa International University Hospital, Mohammed VI University of Health Sciences, Casablanca, MAR.

Coronavirus disease 2019 (COVID-19) has been described as being primarily responsible for respiratory symptoms. Although several case reports have shown the importance of neurological manifestations, only a few have reported non-convulsive status epilepticus (NCSE) as the first manifestation of COVID-19 infection. Here, we report the case of a 30-year-old male patient with no past medical history who was admitted with altered consciousness. Read More

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Ketogenic Diet in the Treatment of Super-Refractory Status Epilepticus at a Pediatric Intensive Care Unit: A Single-Center Experience.

Front Neurol 2021 3;12:669296. Epub 2021 Jun 3.

Department of Pediatrics and Adolescent Medicine, Medical University Vienna, Vienna, Austria.

To evaluate the use of the ketogenic diet (KD) for treatment of super-refractory status epilepticus (SRSE) at a pediatric intensive care unit (PICU). A retrospective analysis of all pediatric patients treated for SRSE with the KD at our center was performed using patient data from our prospective longitudinal KD database. SRSE is defined as refractory SE that continues or recurs 24 h or more after initiation of anesthetic drugs. Read More

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Indications for Inpatient Magnetoencephalography in Children - An Institution's Experience.

Front Hum Neurosci 2021 4;15:667777. Epub 2021 Jun 4.

Division of Child Neurology, Department of Pediatrics, McGovern Medical School, Houston, TX, United States.

Magnetoencephalography (MEG) is recognized as a valuable non-invasive clinical method for localization of the epileptogenic zone and critical functional areas, as part of a pre-surgical evaluation for patients with pharmaco-resistant epilepsy. MEG is also useful in localizing functional areas as part of pre-surgical planning for tumor resection. MEG is usually performed in an outpatient setting, as one part of an evaluation that can include a variety of other testing modalities including 3-Tesla MRI and inpatient video-electroencephalography monitoring. Read More

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