4,312 results match your criteria EEG in Status Epilepticus


Human induced pluripotent stem cell-derived MGE cell grafting after status epilepticus attenuates chronic epilepsy and comorbidities via synaptic integration.

Proc Natl Acad Sci U S A 2018 Dec 17. Epub 2018 Dec 17.

Institute for Regenerative Medicine, Texas A&M Health Science Center College of Medicine, Temple, TX 76502;

Medial ganglionic eminence (MGE)-like interneuron precursors derived from human induced pluripotent stem cells (hiPSCs) are ideal for developing patient-specific cell therapy in temporal lobe epilepsy (TLE). However, their efficacy for alleviating spontaneous recurrent seizures (SRS) or cognitive, memory, and mood impairments has never been tested in models of TLE. Through comprehensive video- electroencephalographic recordings and a battery of behavioral tests in a rat model, we demonstrate that grafting of hiPSC-derived MGE-like interneuron precursors into the hippocampus after status epilepticus (SE) greatly restrained SRS and alleviated cognitive, memory, and mood dysfunction in the chronic phase of TLE. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1814185115DOI Listing
December 2018

The clinical utility of ambulatory EEG in childhood.

Seizure 2018 Nov 29;64:45-49. Epub 2018 Nov 29.

School of Medicine, College of Medical & Veterinary Life Sciences, University of Glasgow, United Kingdom; Paediatric Neurosciences Research Group & EEG Department, Royal Hospital for Children, Glasgow, United Kingdom. Electronic address:

Purpose: To evaluate the clinical utility of the ambulatory electroencephalogram (AEEG) in children.

Method: Data from 199 consecutive referrals for a paediatric AEEG were reviewed retrospectively. Information was gathered on various aspects of the referral process, the characteristics of the children referred and the reasons for referral. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S10591311183058
Publisher Site
http://dx.doi.org/10.1016/j.seizure.2018.11.020DOI Listing
November 2018
1 Read

Acute non-convulsive status epilepticus after experimental traumatic brain injury in rats.

J Neurotrauma 2018 Dec 13. Epub 2018 Dec 13.

University of Eastern Finalnd , Neulaniementie 2 , Kuopio, Finland , 70211 ;

Severe traumatic brain injury (TBI) induces seizures or status epilepticus (SE) in 20%-30% of patients during the acute phase. We hypothesized that severe TBI induced with lateral fluid-percussion injury (FPI) triggers post-impact SE. Adult Sprague-Dawley male rats were anesthetized with isoflurane and randomized into sham-operated experimental control or lateral FPI-induced severe TBI groups. Read More

View Article

Download full-text PDF

Source
https://www.liebertpub.com/doi/10.1089/neu.2018.6107
Publisher Site
http://dx.doi.org/10.1089/neu.2018.6107DOI Listing
December 2018
1 Read

New-Onset Geriatric Epilepsy in China: A Single-Center Study.

Chin Med J (Engl) 2018 Dec;131(24):2915-2920

Department of Neurology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.

Background: Few studies have been published on new-onset geriatric epilepsy especially in older Chinese people. This study was to have a comprehensive understanding of new-onset geriatric epilepsy and find a more reasonable diagnosis and management of epilepsy in older people.

Methods: One hundred and three patients with onset age 60 years and older were admitted between January 2008 and December 2016. Read More

View Article

Download full-text PDF

Source
http://www.cmj.org/text.asp?2018/131/24/2915/247194
Publisher Site
http://dx.doi.org/10.4103/0366-6999.247194DOI Listing
December 2018
2 Reads

De novo absence status epilepticus in three paediatric patients: a new idiopathic epilepsy syndrome?

Epileptic Disord 2018 Dec 10. Epub 2018 Dec 10.

Hospital de Pediatría "La madre y el Niño", Formosa, Argentina.

Absence status epilepticus (ASE) is a prolonged generalized absence seizure that usually lasts for hours and can even last for days. The main symptom is the altered content of consciousness while the patient may be alert and partly responsive. We describe the electroclinical features, treatment, and evolution of three paediatric patients with de novo ASE with an excellent response to valproic acid (VPA). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1684/epd.2018.1008DOI Listing
December 2018

KCNQ2 mutation in an infant with encephalopathy of infancy with migrating focal seizures.

Epileptic Disord 2018 Dec 10. Epub 2018 Dec 10.

Department of Pediatrics (Neurology), McMaster University, 1280 Main St., W. Hamilton, Ontario L8S 4K1, Canada.

A male neonate presented with seizures at 18 hours of life, characterized by tonic posturing with eye deviation to the right, apnoea, bradycardia, and oxygen desaturation. Initial structural, metabolic, and infectious work-up was unremarkable. He continued to have seizures refractory to a variety of antiepileptic medications. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1684/epd.2018.1011DOI Listing
December 2018

Juvenile absence epilepsy relapsing as recurrent absence status, mimicking transient global amnesia, in an elderly patient.

Epileptic Disord 2018 Dec 10. Epub 2018 Dec 10.

IRCCS Institute of Neurological Sciences, Bologna, Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy.

We describe a 68-year-old woman who had typical absence seizures since 14 years of age. The absences were refractory to treatment and persisted into adulthood, with no seizure-free periods until seizure control at 59 years of age. After six years of being seizure-free, she presented with an episode characterized by mental confusion, abnormal behaviour, and amnesia, lasting for several hours. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1684/epd.2018.1016DOI Listing
December 2018

Nonconvulsive Seizure Detection by Reduced-Lead Electroencephalography in Children with Altered Mental Status in the Emergency Department.

J Pediatr 2018 Dec 7. Epub 2018 Dec 7.

Department of Pediatrics, Kobe University Graduate School of Medicine, Kobe, Japan.

Objectives: To evaluate the proportion of children presenting to the emergency department (ED) with altered mental status who demonstrate nonconvulsive seizures on reduced-lead electroencephalography (EEG), and to further investigate the characteristics, treatment, and outcomes in these patients compared with patients without nonconvulsive seizures.

Study Design: In this retrospective cohort study, we reviewed the database and medical records of pediatric patients (aged <18 years) in a single ED between May 1, 2016, and April 30, 2018. We first determined the proportion of nonconvulsive seizures among patients with altered mental status (Glasgow Coma Scale <15). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jpeds.2018.11.019DOI Listing
December 2018

Conventional and quantitative EEG in status epilepticus.

Seizure 2018 Oct 6. Epub 2018 Oct 6.

Departments of Neurology and Pediatrics, The Children's Hospital of Philadelphia and the University of Pennsylvania; 3501 Civic Center Blvd. Philadelphia, PA, 19104.

Purpose: To summarize the use of continuous electroencephalographic monitoring (cEEG) in the diagnosis and management of pediatric convulsive status epilepticus (CSE) and subsequent non-convulsive seizures (NCS) with a focus on available guidelines and infrastructure. In addition, we provide an overview of quantitative EEG (QEEG) for the identification of NCS in critically ill children.

Methods: We performed a review of the medical literature on the use of cEEG and QEEG in pediatric CSE. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.seizure.2018.09.011DOI Listing
October 2018

Pupillary hippus as clinical manifestation of refractory autonomic nonconvulsive status epilepticus: Pathophysiological implications.

Seizure 2018 Dec 15;63:102-104. Epub 2018 Nov 15.

Department of Intensive Medicine, Marqués de Valdecilla University Hospital, Santander, Cantabria, Spain; Department of Biomedical Research Institute (IDIVAL), Santander, Spain.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.seizure.2018.11.006DOI Listing
December 2018

Creutzfeldt-Jakob Disease Presenting as Nonconvulsive Status Epilepticus.

Case Rep Neurol Med 2018 4;2018:3092018. Epub 2018 Nov 4.

Department of Neurology and Neurosurgery, University of Tartu, Estonia.

Creutzfeldt-Jakob disease is a rare, rapidly progressive spongiform encephalopathy in humans. EEG plays an important role in diagnosing this disease. In some patients, epileptic activity and encephalopathy from various aetiologies may share morphological features on EEG. Read More

View Article

Download full-text PDF

Source
https://www.hindawi.com/journals/crinm/2018/3092018/
Publisher Site
http://dx.doi.org/10.1155/2018/3092018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6241237PMC
November 2018
6 Reads

Continuous EEG is associated with favorable hospitalization outcomes for critically ill patients.

Neurology 2018 Nov 30. Epub 2018 Nov 30.

From the Department of Neurology (C.E.H., L.J.B., D.T., K.A.D., N.D., B.L., A.W.W.), Leonard Davis Institute of Health Economics (C.E.H., N.D., A.W.W.), Translational Center of Excellence for Neurology Outcomes Research, Department of Neurology (D.T., A.W.W.), and Department of Biostatistics, Epidemiology and Informatics (A.W.W.), University of Pennsylvania, Philadelphia.

Objective: To characterize continuous EEG (cEEG) use patterns in the critically ill and to determine the association with hospitalization outcomes for specific diagnoses.

Methods: We performed a retrospective cross-sectional study with National Inpatient Sample data from 2004 to 2013. We sampled hospitalized adult patients who received intensive care and then compared patients who underwent cEEG to those who did not. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1212/WNL.0000000000006689DOI Listing
November 2018
1 Read

Status Epilepticus, Refractory Status Epilepticus, and Super-refractory Status Epilepticus.

Continuum (Minneap Minn) 2018 Dec;24(6):1683-1707

Purpose Of Review: Status epilepticus, refractory status epilepticus, and super-refractory status epilepticus can be life-threatening conditions. This article presents an overview of the three conditions and discusses their management and outcomes.

Recent Findings: Status epilepticus was previously defined as lasting for 30 minutes or longer but now is more often defined as lasting 5 minutes or longer. Read More

View Article

Download full-text PDF

Source
http://Insights.ovid.com/crossref?an=00132979-201812000-0000
Publisher Site
http://dx.doi.org/10.1212/CON.0000000000000668DOI Listing
December 2018
8 Reads

Characterisation of neonatal seizures and their treatment using continuous EEG monitoring: a multicentre experience.

Arch Dis Child Fetal Neonatal Ed 2018 Nov 24. Epub 2018 Nov 24.

Irish Centre for Fetal and Neonatal Translational Research (INFANT), Cork, Ireland.

Objective: The aim of this multicentre study was to describe detailed characteristics of electrographic seizures in a cohort of neonates monitored with multichannel continuous electroencephalography (cEEG) in 6 European centres.

Methods: Neonates of at least 36 weeks of gestation who required cEEG monitoring for clinical concerns were eligible, and were enrolled prospectively over 2 years from June 2013. Additional retrospective data were available from two centres for January 2011 to February 2014. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/archdischild-2018-315624DOI Listing
November 2018
3 Reads

Efficacy, safety, and pharmacokinetics of intravenous midazolam in Japanese children with status epilepticus.

J Neurol Sci 2018 Oct 4;396:150-158. Epub 2018 Oct 4.

Department of Pediatrics, Tokyo Women's Medical University, 8-1 Kawada-cho, Shinjuku-ku, Tokyo 162-8666, Japan. Electronic address:

Background: No dosing regimen has been established for the initial treatment of pediatric status epilepticus with intravenous midazolam. We therefore evaluated the efficacy, safety, and pharmacokinetics of bolus and continuous midazolam infusion.

Methods: This open-label, prospective, multicenter study involved 34 Japanese children with status epilepticus unresponsive to diazepam. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S0022510X183041
Publisher Site
http://dx.doi.org/10.1016/j.jns.2018.09.035DOI Listing
October 2018
6 Reads

Defining the electroclinical phenotype and outcome of PCDH19-related epilepsy: A multicenter study.

Epilepsia 2018 Dec 19;59(12):2260-2271. Epub 2018 Nov 19.

Neurology Unit, Department of Neuroscience, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.

Objective: PCDH19-related epilepsy is an epileptic syndrome with infantile onset, characterized by clustered and fever-induced seizures, often associated with intellectual disability (ID) and autistic features. The aim of this study was to analyze a large cohort of patients with PCDH19-related epilepsy and better define the epileptic phenotype, genotype-phenotype correlations, and related outcome-predicting factors.

Methods: We retrospectively collected genetic, clinical, and electroencephalogram (EEG) data of 61 patients with PCDH19-related epilepsy followed at 15 epilepsy centers. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/epi.14600
Publisher Site
http://dx.doi.org/10.1111/epi.14600DOI Listing
December 2018
11 Reads
4.571 Impact Factor

Ictal vomiting after cerebellar hemorrhage: A case report.

Epilepsy Behav Case Rep 2018 11;10:137-140. Epub 2018 Sep 11.

Department of Neurosurgery, Tokyo Women's Medical University, Tokyo, Japan.

Vomiting is a typical symptom of cerebellar hemorrhage. Usually only supportive care such as antiemetic drugs are available. A 76-year-old woman presented in a light coma. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ebcr.2018.08.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6226560PMC
September 2018
1 Read

Rapid Annotation of Seizures and Interictal-ictal Continuum EEG Patterns.

Conf Proc IEEE Eng Med Biol Soc 2018 Jul;2018:3394-3397

Seizures, status epilepticus, and seizure-like rhythmic or periodic activities are common, pathological, harmful states of brain electrical activity seen in the electroencephalogram (EEG) of patients during critical medical illnesses or acute brain injury. Accumulating evidence shows that these states, when prolonged, cause neurological injury. In this study we developed a valid method to automatically discover a small number of homogeneous pattern clusters, to facilitate efficient interactive labelling by EEG experts. Read More

View Article

Download full-text PDF

Source
https://ieeexplore.ieee.org/document/8513059/
Publisher Site
http://dx.doi.org/10.1109/EMBC.2018.8513059DOI Listing
July 2018
6 Reads

Electroencephalography in Pediatric Epilepsy.

Indian Pediatr 2018 Oct;55(10):893-901

Department of Pediatrics, BL Kapur Superspeciality Hospital, Delhi; India.

Surface electroencephalography (EEG) is a useful electrophysiological investigation for evaluating a paroxysmal event in children. It measures the electro potential difference between two points on the scalp. It is a non-invasive tool that analyzes neuronal maturation and abnormal cortical excitability. Read More

View Article

Download full-text PDF

Source
October 2018
2 Reads

The epidemiology of drug-resistant epilepsy: A systematic review and meta-analysis.

Epilepsia 2018 Dec 13;59(12):2179-2193. Epub 2018 Nov 13.

Refractory Epilepsy Unit, Neurology Service, Hospital Universitario y Politécnico La Fe, Valencia, Spain.

Objective: The definition of drug-resistant epilepsy (DRE) affects case identification and treatment, and impacts prevalence or incidence estimates and health burden estimation in epidemiology. The objective of this systematic review is to evaluate the consistency between definitions of DRE in the literature and the official definition in the International League Against Epilepsy (ILAE) guidelines, and to estimate the incidence, prevalence, and risk factors for DRE.

Methods: MEDLINE and EMBASE were searched for observational studies of DRE published between January 1980 and July 2015. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/epi.14596
Publisher Site
http://dx.doi.org/10.1111/epi.14596DOI Listing
December 2018
3 Reads

Protective effects of the ROCK inhibitor fasudil against cognitive dysfunction following status epilepticus in male rats.

J Neurosci Res 2018 Nov 12. Epub 2018 Nov 12.

Pediatric Research Institute, Children's Hospital of Chongqing Medical University, Ministry of Education Key Laboratory of Child Development and Disorders, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing Key Laboratory of Pediatrics, Chongqing, China.

Despite remarkable advances in epilepsy research, prevention and reversal of cognitive deficits following epilepsy remain a challenge. It was reported that the Rho kinase (ROCK) inhibitor fasudil hydrochloride (FH) could improve cognitive deficits in animal models of Alzheimer's disease (AD). Thus, the aim of the present study was to determine whether FH-mediated inhibition of the effects of ROCK signaling could improve cognitive deficits in male rats (postnatal 21-day old) following status epilepticus (SE) induced by lithium-pilocarpin, the therapeutic window of opportunity and to elucidate the underlying mechanisms. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/jnr.24355
Publisher Site
http://dx.doi.org/10.1002/jnr.24355DOI Listing
November 2018
3 Reads

Neurologic phenotypes associated with / mutations: Expanding the spectrum of disease.

Neurology 2018 Nov 9;91(22):e2078-e2088. Epub 2018 Nov 9.

From the Department of Clinical and Experimental Epilepsy (S.Z., Z.M., L.H.-H., S.K., S. Balestrini, S.M.S.) and Division of Neuropathology (Z.M., M.T.), UCL Institute of Neurology, London, UK; Clinic of Neurology (S.Z.), Department of Experimental and Clinical Medicine, Marche Polytechnic University, Ancona, Italy; Department of Pediatric Neurology and Neurological Rehabilitation (C.S., T.H., P.W., G.J.K.) and Neurosurgery Clinic and Clinic for Epilepsy Surgery (M.K.), Schön Klinik Vogtareuth; Department of Pediatrics (C.S., M.S.), Children's Hospital Augsburg, Germany; UCL Great Ormond Street Institute of Child Health (J.R.N., K.V., S.M.V., J.H.C.), London, UK; Paediatric Neurology and Neurogenetics Unit and Laboratories (D.M., R.G.), A. Meyer Children's Hospital, University of Florence, Italy; Chalfont Centre for Epilepsy (Z.M., L.H.-H., S.K., S. Balestrini, S.M.S.), Chalfont-St-Peter, Buckinghamshire, UK; CeGaT-Center for Genomics and Transcriptomics (A.P., S. Biskup), Tübingen, Germany; Neurogenetics Unit (M.L.), Department of Medical Genetics, Hospital de São João, Porto, Portugal; Department of Pediatrics and Adolescent Medicine (J.G.), University Medical Center Göttingen; Hospital for Children and Adolescents (A.M.), University Clinic Leipzig, Germany; Freiburg Medical Laboratory (M.J.), Dubai; The Danish Epilepsy Centre (R.S.M., E.G.), Dianalund; Institute for Regional Health Services (R.S.M., E.G.), University of Southern Denmark, Odense; Department of Clinical Genetics (B.S.K.), Odense University Hospital; Hans Christian Andersen Children's Hospital (L.K.H.), Odense, Denmark; Pediatric Neurology and Muscular Diseases Unit (M.S.V., P.S.), Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, and Maternal and Child Health, University of Genoa "G. Gaslini" Institute, Italy; Division of Neurology (K.L.H.), Children's Hospital of Philadelphia, PA; Department of Neurology (S.D., C.L.S.-H.), Division of Neurogenetics, Kennedy Krieger Institute, Baltimore, MD; Center for Genomic Medicine (N.H.-F.), Tohoku University; Department of Pediatrics (N.H.-F.), Tohoku University School of Medicine, Sendai, Japan; Department of Pediatrics (T.T., R.L.) and Institute of Clinical Medicine (K.O.), University of Tartu; Children's Clinic (T.T., R.L.), Department of Radiology (P.I.), and Department of Clinical Genetics, United Laboratories (K.O.), Tartu University Hospital, Estonia; Ludwig-Maximilians-University Munich (I.K.); Department of Pediatric Neurology (A.H.), Clinic Traunstein; Children's Hospital (M.K.), Dr. Horst Schmidt Klinik, Wiesbaden; Altona Children's Hospital (J.H.), Hamburg; Department of Pediatrics (C. Makowski), Technische Universität München, Germany; Department of Clinical Genetics (S.G.), Royal North Shore Hospital, St Leonards; John Hunter Children's Hospital (G.M.S.), New Lambton Heights, New South Wales, Australia; Department of Neurology (R.T.), University Hospital of Wales; Institute of Psychological Medicine and Clinical Neurosciences (R.H.T.), Cardiff University; Division of Neuroradiology (C. Micallef), National Hospital for Neurology and Neurosurgery, London; Department of Brain Repair & Rehabilitation (D.J.W.), Stroke Research Centre, UCL Institute of Neurology, London, UK; Paracelsus Medical University (G.J.K.), Salzburg, Austria; and IRCCS Stella Maris Foundation (R.G.), Pisa, Italy.

Objective: To characterize the neurologic phenotypes associated with mutations and to seek genotype-phenotype correlation.

Methods: We analyzed clinical, EEG, and neuroimaging data of 44 new and 55 previously reported patients with mutations.

Results: Childhood-onset focal seizures, frequently complicated by status epilepticus and resistance to antiepileptic drugs, was the most common phenotype. Read More

View Article

Download full-text PDF

Source
http://www.neurology.org/lookup/doi/10.1212/WNL.000000000000
Publisher Site
http://dx.doi.org/10.1212/WNL.0000000000006567DOI Listing
November 2018
5 Reads

Development of permanent brain damage after subacute encephalopathy with seizures in alcoholics.

J Neurol Sci 2018 Oct 25;396:12-17. Epub 2018 Oct 25.

Unit of Neurology and Clinical Neurophysiology, University hospital Bretonneau, Tours, France.

Purpose: To describe additional cases of subacute encephalopathy with seizures in alcoholics (SESA) syndrome, and to question the clinical and radiological course.

Methods: We retrospectively analyzed the clinical characteristics, electroencephalography (EEG), MRI studies at the admission and over the following 6 months of 5 cases of SESA syndrome visited our neurology department between 2010 and 2016.

Results: Five middle-aged males with history of chronic alcohol abuse were admitted for confusion, neurological deficit and seizures. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S0022510X183043
Publisher Site
http://dx.doi.org/10.1016/j.jns.2018.10.022DOI Listing
October 2018
27 Reads

Treatment Options for Anti-N-methyl-D-aspartate Receptor Encephalitis.

Neurodiagn J 2018 Nov 2:1-9. Epub 2018 Nov 2.

a CISSS Montérégie Center, Charles-Le Moyne Hospital, Neurology Department , Sherbrooke University Affiliated , Greenfield Park , Québec , Canada.

Anti-NMDAR encephalitis is an autoimmune limbic disorder with an unknown cause, which affects mostly young women. Behavioral changes, seizures, orofacial muscle contractions, and memory impairment are usually observed. The variability of the symptoms depends on which part of the brain is inflamed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/21646821.2018.1523640DOI Listing
November 2018
4 Reads

Neurologic outcome of postanoxic refractory status epilepticus after aggressive treatment.

Neurology 2018 Dec 31;91(23):e2153-e2162. Epub 2018 Oct 31.

From the Epilepsy Center (S.B., C.Z., D.C. A.S., G.P., G.B., C.F.), Department of Neurology, and Department of Intensive Care (A.C., E.S., A.G., G.F., L.A.), San Gerardo Hospital ASST Monza, University of Milano Bicocca, Monza; Department of Neuroscience (E.B., E.B.), IRCCS Mario Negri Institute for Pharmacological Research; and Department of Anesthesia (A.P.), Critical Care and Emergency, IRCCS Ospedale Maggiore Policlinico, Milano, Italy.

Objective: To investigate neurologic outcome of patients with cardiac arrest with refractory status epilepticus (RSE) treated with a standardized aggressive protocol with antiepileptic drugs and anesthetics compared to patients with other EEG patterns.

Methods: In the prospective cohort study, 166 consecutive patients with cardiac arrest in coma were stratified according to 4 independent EEG patterns (benign, RSE, generalized periodic discharges [GPDs], malignant nonepileptiform) and multimodal prognostic indicators. Primary outcomes were survival and cerebral performance category (CPC) at 6 months. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1212/WNL.0000000000006615DOI Listing
December 2018
2 Reads

Variability in pharmacologically-induced coma for treatment of refractory status epilepticus.

PLoS One 2018 31;13(10):e0205789. Epub 2018 Oct 31.

Massachusetts General Hospital, Harvard Medical School, Cambridge, Massachusetts, United States of America.

Objective: To characterize the amount of EEG suppression achieved in refractory status epilepticus (RSE) patients treated with pharmacologically-induced coma (PIC).

Methods: We analyzed EEG recordings from 35 RSE patients between 21-84 years-old who received PIC that target burst suppression and quantified the amount of EEG suppression using the burst suppression probability (BSP). Then we measured the variability of BSPs with respect to a reference level of BSP 0. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0205789PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6209214PMC
October 2018
5 Reads

Cefepime-induced encephalopathy: Neural mass modeling of triphasic wave-like generalized periodic discharges with a high negative component (Tri-HNC).

Psychiatry Clin Neurosci 2018 Oct 29. Epub 2018 Oct 29.

Department of Neuropsychiatry, Tokyo Metropolitan Tama Medical Center, Tokyo, Japan.

Aim: Cefepime, a fourth-generation cephalosporin, acts as a GABA receptor antagonist. Cefepime-induced encephalopathy (CIE) is frequently overlooked. We aimed to clarify the clinical features, characteristic electroencephalography (EEG), and mechanisms of CIE to aid in its early recognition. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/pcn.12795
Publisher Site
http://dx.doi.org/10.1111/pcn.12795DOI Listing
October 2018
4 Reads

Soman-induced status epilepticus, epileptogenesis, and neuropathology in carboxylesterase knockout mice treated with midazolam.

Epilepsia 2018 Dec 25;59(12):2206-2218. Epub 2018 Oct 25.

US Army Medical Research Institute of Chemical Defense, Aberdeen Proving Ground, Maryland.

Objective: Exposure to chemical warfare nerve agents (CWNAs), such as soman (GD), can induce status epilepticus (SE) that becomes refractory to benzodiazepines when treatment is delayed, leading to increased risk of epileptogenesis, severe neuropathology, and long-term behavioral and cognitive deficits. Rodent models, widely used to evaluate novel medical countermeasures (MCMs) against CWNA exposure, normally express plasma carboxylesterase, an enzyme involved in the metabolism of certain organophosphorus compounds. To better predict the efficacy of novel MCMs against CWNA exposure in human casualties, it is crucial to use appropriate animal models that mirror the human condition. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/epi.14582
Publisher Site
http://dx.doi.org/10.1111/epi.14582DOI Listing
December 2018
3 Reads

Improved seizure control and regaining cognitive milestones after vagus nerve stimulation revision surgery in Lennox-Gastaut syndrome.

Epilepsy Behav Case Rep 2018 11;10:111-113. Epub 2018 Sep 11.

Department of Neurosurgery, Maastricht UMC +, P. Debyelaan 25, 6202 AZ Maastricht, the Netherlands.

We report a child with Lennox-Gastaut syndrome with an increase in seizure frequency and loss of psychomotor skills due to a disintegrated cervical VNS lead, not detected during standard device monitoring. The lead was completely removed and replaced by a new 303 lead on the same nerve segment. After reinitiating VNS, side effects forced us to switch it off, resulting in immediate seizure recurrence. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ebcr.2018.08.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6197149PMC
September 2018
2 Reads

Multimodal Predictions of Super-Refractory Status Epilepticus and Outcome in Status Epilepticus Due to Acute Encephalitis.

Front Neurol 2018 8;9:832. Epub 2018 Oct 8.

Department of Neurology, Xijing Hospital, Fourth Military Medical University, Xi'an, China.

Status epilepticus (SE) is one of the most critical symptoms of encephalitis. Studies on early predictions of progression to super-refractory status epilepticus (SRSE) and poor outcome in SE due to acute encephalitis are scarce. We aimed to investigate the values of neuroimaging and continuous electroencephalogram (EEG) in the multimodal prediction. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fneur.2018.00832DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6186801PMC
October 2018
1 Read

External validation of the epidemiology-based mortality score in status epilepticus in an American intensive care population.

Epilepsy Res 2018 Dec 3;148:32-36. Epub 2018 Oct 3.

Department of Neurosurgery, UT Health San Antonio Lozano School of Medicine, United States.

Introduction: Although overall mortality of status epilepticus is high, baseline patient characteristics and co-morbidities may be helpful to predict outcomes and shape treatment decisions. Two previously published scoring systems exist to predict outcomes: the Status Epilepticus Severity Score (STESS) and the Epidemiology-based Mortality Score in Status Epilepticus (EMSE). However, a comparison of the two scores has not previously been completed in an American intensive care unit. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.eplepsyres.2018.10.001DOI Listing
December 2018
1 Read

Clinical and electrographic characteristics of seizures in LGI1-antibody encephalitis.

Epilepsy Behav 2018 Nov 15;88:277-282. Epub 2018 Oct 15.

Department of Neurology, First Affiliated Hospital of Zhengzhou University, China. Electronic address:

Purpose: The purpose of this study was to analyze the clinical and electrographic characteristics of seizures in LGI1-antibody encephalitis.

Methods: The methods utilized in this study were prospective analysis of the clinical manifestations, types of seizures, electroencephalogram (EEG), adjuvant examination, treatment and prognosis of 19 cases of LGI1-antibody encephalitis diagnosed from January 2017 to February 2018 in First Affiliated Hospital of Zhengzhou University, and reviewed related literatures.

Results: The 15/19 (79%) patients were male, and the average onset age was 58 years (23-82). Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S15255050183051
Publisher Site
http://dx.doi.org/10.1016/j.yebeh.2018.08.019DOI Listing
November 2018
10 Reads

Prognostic value of continuous electroencephalography in children undergoing therapeutic hypothermia after cardiac arrest: A pilot study.

Neurophysiol Clin 2018 Oct 12. Epub 2018 Oct 12.

Division of pulmonary and critical care, department of pediatrics, faculty of medicine, Chulalongkorn University, Thailand.

Objective: To determine the prognostic value of continuous electroencephalography (EEG) in children undergoing therapeutic hypothermia after cardiac arrest.

Method: We retrospectively reviewed medical records and continuous EEG of all patients undergoing therapeutic hypothermia after cardiac arrest from November 2013 to September 2016. Demographic, clinical data and immediate complications were collected. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neucli.2018.09.002DOI Listing
October 2018
1 Read

Early Diagnosis of Nonconvulsive Status Epilepticus Recurrence with Raw EEG of a Bispectral Index Monitor.

Authors:
Aristide Ntahe

Case Rep Crit Care 2018 12;2018:1208401. Epub 2018 Sep 12.

Département d'Anesthésie-Réanimation, Hôpital Saint-Louis, Assistance Publique-Hôpitaux de Paris, 1 Avenue Claude Vellefaux, 75010 Paris, France.

Background: Seizures are frequent in ICU and their diagnosis is challenging, often delayed or missed. Their diagnosis requires a conventional EEG recording. When cEEG is not available, there is no consensus on how patients should be monitored when there is high risk of seizure. Read More

View Article

Download full-text PDF

Source
https://www.hindawi.com/journals/cricc/2018/1208401/
Publisher Site
http://dx.doi.org/10.1155/2018/1208401DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6157206PMC
September 2018
1 Read

Epilepsy-predictive magnetic resonance imaging changes following experimental febrile status epilepticus: Are they translatable to the clinic?

Epilepsia 2018 Nov 6;59(11):2005-2018. Epub 2018 Sep 6.

Department of Anatomy/Neurobiology, University of California, Irvine, Irvine, California.

Objective: A subset of children with febrile status epilepticus (FSE) are at risk for development of temporal lobe epilepsy later in life. We sought a noninvasive predictive marker of those at risk that can be identified soon after FSE, within a clinically realistic timeframe.

Methods: Longitudinal T -weighted magnetic resonance imaging (T WI MRI) of rat pups at several time points after experimental FSE (eFSE) was performed on a high-field scanner followed by long-term continuous electroencephalography. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/epi.14561DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6217797PMC
November 2018
4 Reads

Prevalence of Seizures in Pediatric Extracorporeal Membrane Oxygenation Patients as Measured by Continuous Electroencephalography.

Pediatr Crit Care Med 2018 Dec;19(12):1162-1167

Department of Neurology, New York - Presbyterian, Columbia University Herbert and Florence Irving Medical Center, New York, NY.

Objectives: Standards for neuromonitoring during extracorporeal membrane oxygenation support do not currently exist, and there is wide variability in practice. We present our institutional experience at an academic children's hospital since establishment of a continuous electroencephalography monitoring protocol for extracorporeal membrane oxygenation patients.

Design: Retrospective, single-center study. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/PCC.0000000000001730DOI Listing
December 2018
2 Reads

Degeneration of cholinergic basal forebrain nuclei after focally evoked status epilepticus.

Neurobiol Dis 2019 Jan 20;121:76-94. Epub 2018 Sep 20.

I.R.C.C.S. I.N.M. Neuromed, via dell'Elettronica 4, 86077, Pozzilli, Italy; Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, via Roma 55, Pisa 56126, Italy. Electronic address:

Status epilepticus (SE) of limbic onset might cause degenerative phenomena in different brain structures, and may be associated with chronic cognitive and EEG effects. In the present study SE was evoked focally by microinfusing picomolar doses of cyclothiazide+bicuculline into the anterior extent of the piriform cortex (APC) in rats, the so-called area tempestas, an approach which allows to evaluate selectively the effects of seizure spreading through the natural anatomical circuitries up to secondary generalization. In the brain of rats submitted to SE we analyzed neuronal density, occurrence of degenerative phenomena (by Fluoro-Jade B-FJB- staining) and expression of heat shock protein-70 (HSP-70) in the piriform cortex, the hippocampus and ventromedial thalamus. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S09699961183060
Publisher Site
http://dx.doi.org/10.1016/j.nbd.2018.09.019DOI Listing
January 2019
7 Reads

The Free Radical Scavenger N-Tert-Butyl-α-Phenylnitrone (PBN) Administered to Immature Rats During Status Epilepticus Alters Neurogenesis and Has Variable Effects, Both Beneficial and Detrimental, on Long-Term Outcomes.

Front Cell Neurosci 2018 28;12:266. Epub 2018 Aug 28.

Department of Developmental Epileptology, Institute of Physiology of the Czech Academy of Sciences, Prague, Czechia.

Status epilepticus (SE), especially in immature animals, is known to produce recurrent spontaneous seizures and behavioral comorbidities later in life. The cause of these adverse long-term outcomes is unknown, but it has been hypothesized that free radicals produced by SE may play a role. We tested this hypothesis by treating immature (P25) rats with the free radical scavenger N-tert-butyl-α-phenylnitrone (PBN) at the time of lithium chloride (LiCl)/pilocarpine (PILO)-induced SE. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fncel.2018.00266DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6121067PMC
August 2018
2 Reads

Electrographic Seizures in Patients with Acute Encephalitis.

Neurocrit Care 2018 Sep 10. Epub 2018 Sep 10.

Department of Neurology, Henry Ford Hospital, 2799 W Grand Blvd, Detroit, MI, 48202, USA.

Introduction: Clinical seizures and status epilepticus are frequent complications of encephalitis, can lead to depressed level of consciousness, and are associated with poor outcome. We sought to determine the frequency, risk factors, and clinical impact of electrographic seizures detected with continuing electroencephalography (cEEG) in patients with encephalitis and altered level of consciousness.

Methods: We retrospectively identified all patients with presumed or definite viral or autoimmune encephalitis who underwent cEEG monitoring at Henry Ford Hospital from January 2012 to October 2017. Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s12028-018-0599-4
Publisher Site
http://dx.doi.org/10.1007/s12028-018-0599-4DOI Listing
September 2018
5 Reads

Potential consequences of high-dose infusion of ketamine for refractory status epilepticus: case reports and systematic literature review.

Anaesth Intensive Care 2018 Sep;46(5):516-528

Professor, Departments of Medicine, Anesthesiology, Neurology and Neurosurgery, NYU School of Medicine, New York, NY, USA.

Our goal was to provide comprehensive data on the effectiveness of ketamine in refractory status epilepticus (RSE) and to describe the potential consequences of long-term ketamine infusion. Ketamine, an N-methyl D-aspartate (NMDA) receptor antagonist, blocks excitatory pathways contributing to ongoing seizure. While ketamine use is standard in anaesthetic induction, no definitive protocol exists for its use in RSE, and little is known about its adverse effects in long-term, high-dose administration. Read More

View Article

Download full-text PDF

Source
September 2018
1 Read

Epilepsia partialis continua following a Western variant tick-borne encephalitis.

J Neurovirol 2018 Dec 5;24(6):773-775. Epub 2018 Sep 5.

Clinical Unit of Neurology, Department of Medicine, Surgery and Health Sciences, University Hospital and Health Services of Trieste, University of Trieste, Trieste, Italy.

Epilepsia partialis continua (EPC) is a rare entity, first described in 1894 by Koževnikov, as a variant of simple focal motor status epilepticus. EPC is most frequently characterized by motor symptoms, but as recently described, non-motor manifestations may occur, such as somatosensory symptoms or aura continua. EPC in adults has been attributed to various etiologies: infectious, vascular, neoplastic, and metabolic. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s13365-018-0671-zDOI Listing
December 2018
2 Reads

The Imaging of Localization Related Symptomatic Epilepsies: The Value of Arterial Spin Labelling Based Magnetic Resonance Perfusion.

Korean J Radiol 2018 Sep-Oct;19(5):965-977. Epub 2018 Aug 6.

Department of Imaging Sciences & Interventional Radiology, Sree Chitra Tirunal Institute for Medical Sciences & Technology (SCTIMST), Trivandrum 695011, India.

Accurate identification of the epileptogenic zone is an important prerequisite in presurgical evaluation of refractory epilepsy since it affects seizure-free outcomes. Apart from structural magnetic resonance imaging (sMRI), delineation has been traditionally done with electroencephalography and nuclear imaging modalities. Arterial spin labelling (ASL) sequence is a non-contrast magnetic resonance perfusion technique capable of providing similar information. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3348/kjr.2018.19.5.965DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6082755PMC
August 2018
6 Reads

Addition of ketamine to standard-of-care countermeasures for acute organophosphate poisoning improves neurobiological outcomes.

Neurotoxicology 2018 Dec 30;69:37-46. Epub 2018 Aug 30.

Biomedical Advanced Research and Development Authority (BARDA), Washington, DC, United States.

Rats poisoned with sarin enter into ahyper-cholinergic crisis characterized by excessive salivation, respiratory distress, tremors, seizures, and death. Through the use of rescue medications and an anticonvulsant, death can be avoided in many animals, with the long-term consequences of poisoning partly ameliorated, especially when countermeasures are made available immediately after exposure. However, when anticonvulsant measures are delayed by as little as 30 min, clinical, neurological, cognitive, and psychiatric abnormalities may persist long after the initial exposure. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S0161813X183034
Publisher Site
http://dx.doi.org/10.1016/j.neuro.2018.08.011DOI Listing
December 2018
8 Reads

The phenotype of developmental and epileptic encephalopathy.

Neurology 2018 Sep 31;91(12):e1112-e1124. Epub 2018 Aug 31.

From the Department of Clinical Neurophysiology (E.G., S.B.), Danish Epilepsy Centre, Dianalund; Institute for Regional Health Services (E.G., K.M.J., R.S.M.), University of Southern Denmark, Odense, Denmark; Neuroscience Department (C.M., R.G., M.M.), Children's Hospital A. Meyer, University of Florence; Department of Neuroscience (M.T., N.S., F.V.), Bambino Gesù Children's Hospital, IRCCS, Rome, Italy; Division of Neurology (M.P.F., I.H.), The Children's Hospital of Philadelphia; Departments of Pediatrics and Neurology (M.P.F., I.H.), Perelman School of Medicine at the University of Pennsylvania, Philadelphia; Universitätskinderklinik Tübingen (M.A., M.W.), Germany; Department of Neurology (K.H.), Royal Children's Hospital Melbourne; Department of Paediatrics (K.H.), University of Melbourne; Australia Neurosciences Group (K.H.), Murdoch Children's Research Institute, Melbourne, Australia; Servizio di Neuropsichiatria Infantile (F.D., E.F.), Policlinico G.B. Rossi, Universita Degli Studi di Verona; Department of Child Neurology (S.S., G.A.), Ospedale Pediatrico G. Salesi-Ospedali Riuniti, Ancona, Italy; Division of Clinical Neurophysiology (B.B.), Children's Research Center, University Children's Hospital Zurich, Switzerland; Brain and Behaviour Department (S.M.), University of Pavia; Department of Pediatric Neuroradiology (A.P.), IRCCS "C. Mondino" National Neurological Institute, Pavia, Italy; Department of Epilepsy Genetics (K.J., R.S.M.), Danish Epilepsy Centre Dianalund; Department of Child Neurology (B.J.), Danish Epilepsy Centre, Dianalund, Denmark; Cytogenetic and Molecular Genetic Laboratory (S.R., F.C.), Istituto Auxologico Italiano, IRCCS, Milano, Italy; Department of Adult Neurology (G.R.), Danish Epilepsy Centre, Dianalund; University of Copenhagen (G.R.), Denmark; Struttura Complessa di Neurologia Pediatrica Ospedale Vittore Buzzi (P.V.), Milano; Dipartimento di Scienze Biomediche e Cliniche L. Sacco (P.V.), Università di Milano, Italy; Århus University (S.B.), Denmark; Department of Child Neurology (I.E.S.), University of Melbourne, Austin Health, Florey Institute; and Department of Child Neurology (I.E.S.), The Royal Children's Hospital, Melbourne, Australia.

Objective: To delineate the electroclinical features of infantile developmental and epileptic encephalopathy (EIEE13, OMIM #614558).

Methods: Twenty-two patients, aged 19 months to 22 years, underwent electroclinical assessment.

Results: Sixteen of 22 patients had mildly delayed development since birth. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1212/WNL.0000000000006199DOI Listing
September 2018
6 Reads

Investigation of the Video-EEG Findings and Clinical Data in Patients Diagnosed With Epilepsy and Psychosis.

Neurologist 2018 Sep;23(5):167-174

Departments of Neurology and Clinical Neurophysiology.

Background: Studies on electrophysiological characteristics of patients with epilepsy and concomitant psychosis are limited. We aimed to investigate the clinical and video-electroencephalography (EEG) findings of patients with epilepsy-related psychosis (EP).

Materials And Methods: Fifteen patients diagnosed with EP, assessed at the video-EEG monitoring unit and were under follow-up at both epilepsy and psychiatry clinics, were included. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/NRL.0000000000000195DOI Listing
September 2018
12 Reads

Neuroimaging of status epilepticus.

Epilepsia 2018 Oct 29;59 Suppl 2:113-119. Epub 2018 Aug 29.

Department of Neurosciences, OCSAE Hospital, AOU Modena, Modena, Italy.

In the past 2 decades we have observed an extensive use of different neuroimaging techniques to evaluate patients with status epilepticus. Magnetic resonance imaging (MRI) in particular may show a broad spectrum of abnormalities that are either the causes or the consequences of sustained epileptic activity. Neuroimaging techniques can offer a contribution both in the clinical management of individual patients, identifying hemodynamic patterns that support the diagnosis, and also in the recognition of periictal reversible or irreversible alterations. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/epi.14499DOI Listing
October 2018
6 Reads

Periodic Slow Waves Presenting as Ictal Electroencephalography Findings in Complex Partial Status Epilepticus.

Case Rep Neurol 2018 May-Aug;10(2):199-206. Epub 2018 Jul 25.

Department of Neuropsychiatry, The University of Tokyo Hospital, Tokyo, Japan.

The diagnosis of nonconvulsive status epilepticus (NCSE) largely relies on electroencephalography (EEG) findings, but the existing diagnostic criteria for EEG results are sometimes inconsistent. Much debate has centered on periodic epileptic discharges (PEDs) and their relationship with seizures. The recently published Salzburg Consensus Criteria for diagnosis of NCSE, which consider PEDs to be ictal findings under several conditions, have been proven to have high diagnostic accuracy. Read More

View Article

Download full-text PDF

Source
https://www.karger.com/Article/FullText/490939
Publisher Site
http://dx.doi.org/10.1159/000490939DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6103353PMC
July 2018
9 Reads

Clinicopathologic Findings of CARS2 Mutation.

Pediatr Neurol 2018 Oct 4;87:65-69. Epub 2018 Jul 4.

Neurology Divison, Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, Arkansas.

Objectives: We describe a 13-year-old girl with a past medical history of epilepsy, intellectual impairment, dysphagia with gastric tube dependence, and autism spectrum disorder who presented with focal status epilepticus.

Methods: Video-electroencephalography revealed left occipital pseudoperiodic epileptiform discharges and frequent seizures originating from the left hemisphere. The seizure was refractory to antiepileptic medications and pharmacologic coma. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S08878994183033
Publisher Site
http://dx.doi.org/10.1016/j.pediatrneurol.2018.06.009DOI Listing
October 2018
6 Reads

Incidence of neonatal seizures, perinatal risk factors for epilepsy and mortality after neonatal seizures in the province of Parma, Italy.

Epilepsia 2018 Sep 22;59(9):1764-1773. Epub 2018 Aug 22.

Department of Neuroscience, IRCCS Istituto Mario Negri, Milan, Italy.

Objective: Information about the incidence of neonatal seizures (NS) is scarce. Previous studies relied primarily on a clinical diagnosis of seizures. This population-based, retrospective study evaluated the incidence of electroencephalography (EEG)-confirmed seizures in neonates born in the province of Parma and the perinatal risk factors for mortality and epilepsy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/epi.14537DOI Listing
September 2018
11 Reads