165,577 results match your criteria EEG in Dementia and Encephalopathy


Therapeutic Hypothermia in Brazil: A MultiProfessional National Survey.

Am J Perinatol 2018 Dec 15. Epub 2018 Dec 15.

Department of Pediatrics, Neonatal Division, McGill University Health Center, Montreal, Quebec, Canada.

Objective:  To determine the rate of therapeutic hypothermia (TH) use, current practices, and long-term follow-up.

Study Design:  Prospective cross-sectional national survey with 19 questions related to the assessment of hypoxic-ischemic encephalopathy (HIE) and TH practices. An online questionnaire was made available to health care professionals working in neonatal care in Brazil. Read More

View Article
December 2018
1 Read

Electrophysiological and behavioral measures of some speech contrasts in varied attention and noise.

Hear Res 2018 Dec 6;373:1-9. Epub 2018 Dec 6.

Lund University Department of Psychology, Paradisgatan 5, Lund, 22100, Sweden. Electronic address:

This paper investigates the salience of speech contrasts in noise, in relation to how listening attention affects scalp-recorded cortical responses. The contrasts that were examined with consonant-vowel syllables, were place of articulation, vowel length and voice-onset time (VOT) and our analysis focuses on the correspondence between the effect of attention on the electrophysiology and the decrement in behavioral results when noise was added to the stimuli. Normal-hearing subjects (n = 20) performed closed-set syllable identification in no noise, 0, 4 and 8 dB signal-noise ratio (SNR). Read More

View Article
December 2018

Effects of acute psychosocial stress on the neural correlates of episodic encoding: Item versus associative memory.

Neurobiol Learn Mem 2018 Dec 12. Epub 2018 Dec 12.

Saarland University.

Acute stress is known to modulate episodic memory, but little is known about the extent to, and the circumstances under, which stress affects encoding of item vs. inter-item associative information for words of different valences. Furthermore, the precise neuro-cognitive mechanisms underlying stress effects on episodic encoding in humans are largely unknown. Read More

View Article
December 2018

ADHD symptoms are associated with decreased activity of fast sleep spindles and poorer procedural overnight learning during adolescence.

Neurobiol Learn Mem 2018 Dec 12. Epub 2018 Dec 12.

Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, 00014 Helsinki, Finland.

ADHD and its subclinical symptoms have been associated with both disturbed sleep and weakened overnight memory consolidation. As sleep spindle activity during NREM sleep plays a key role in both sleep maintenance and memory consolidation, we examined the association between subclinical ADHD symptoms and sleep spindle activity. Furthermore, we hypothesized that sleep spindle activity mediates the effect of ADHD symptoms on overnight learning outcome in a procedural memory task. Read More

View Article
December 2018

Higher sleep spindle activity is associated with fewer false memories in adolescent girls.

Neurobiol Learn Mem 2018 Dec 12. Epub 2018 Dec 12.

Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Helsinki, Finland.

Background: Sleep facilitates the extraction of semantic regularities amongst newly encoded memories, which may also lead to increased false memories. We investigated sleep stage proportions and sleep spindles in the recollection of adolescents' false memories, and their potential sex-specific differences.

Methods: 196 adolescents (mean age 16. Read More

View Article
December 2018

Differential executive functioning in young adulthood as a function of experienced child abuse.

Int J Psychophysiol 2018 Dec 12. Epub 2018 Dec 12.

University of North Dakota, United States of America.

Introduction: Previous research has shown cognitive dysfunction in adults with a history of child abuse. The purpose of the present study was to measure differences that exist in executive functioning skills between individuals who have been abused as children versus those without the history of childhood abuse.

Methods: The present study recruited 43 students from the University of North Dakota (33 women) between ages 18 and 23 years of age. Read More

View Article
December 2018

On the (Non-)equivalency of monopolar and bipolar settings for deep brain stimulation fMRI studies of Parkinson's disease patients.

J Magn Reson Imaging 2018 Dec 15. Epub 2018 Dec 15.

GE Global Research Center, Bangalore, India.

Background: The majority of Parkinson's disease patients with deep brain stimulation (DBS) use a monopolar configuration, which presents challenges for EEG and MRI studies. The literature reports algorithms to convert monopolar to bipolar settings.

Purpose/hypothesis: To assess brain responses of Parkinson's disease patients implanted with DBS during fMRI studies using their clinical and presumed equivalent settings using a published conversion recipe. Read More

View Article
December 2018

Power and phase coherence in sensorimotor mu and temporal lobe alpha components during covert and overt syllable production.

Exp Brain Res 2018 Dec 14. Epub 2018 Dec 14.

Department of Hearing, Speech, and Language Sciences, Gallaudet University, 800 Florida Ave, Washington, DC, USA.

The sensorimotor dorsal stream is known to activate in both overt and covert speech production. However, overt production produces sensory consequences that are absent during covert production. Thus, the purpose of the current study is to investigate differences in dorsal stream activity between these two production conditions across the time course of utterances. Read More

View Article
December 2018

Individual spindle detection and analysis in high-density recordings across the night and in thalamic stroke.

Sci Rep 2018 Dec 14;8(1):17885. Epub 2018 Dec 14.

Department of Neurology, University Hospital (Inselspital) and University of Bern, Bern, Switzerland.

Sleep spindles are thalamocortical oscillations associated with several behavioural and clinical phenomena. In clinical populations, spindle activity has been shown to be reduced in schizophrenia, as well as after thalamic stroke. Automatic spindle detection algorithms present the only feasible way to systematically examine individual spindle characteristics. Read More

View Article
December 2018

Sleep-disordered breathing among patients admitted for inpatient video-EEG monitoring.

Neurology 2018 Dec 14. Epub 2018 Dec 14.

From the Departments of Medicine (S.S., Z.C., A.P., C.J.R., N.C.J., C.F., P.P., P.K., T.J.O.), Neurology (S.S., E.J.W., A.P., C.H., J.C., C.J.R., R.Y., C.F., P.P., P.K., T.J.O.), and Respiratory and Sleep Disorders Medicine (T.M., J.G.), The Royal Melbourne Hospital, The University of Melbourne, Parkville; Department of Neuroscience (S.S., Z.C., A.P., N.C.J., C.F., P.P., P.K., T.J.O.), Central Clinical School, Monash University; Department of Neurology (S.S., A.P., P.P., P.K., T.J.O.), The Alfred Hospital; and Neuropsychiatry Unit (S.F., D.V.), The Royal Melbourne Hospital and Melbourne Neuropsychiatry Centre, Australia.

Objective: To examine the prevalence and risk factors of sleep-disordered breathing (SDB) in individuals with epilepsy and psychogenic nonepileptic seizures (PNES).

Methods: We conducted a cross-sectional study of consecutive patients admitted for inpatient video-EEG monitoring at The Royal Melbourne Hospital, Australia, between December 1, 2011, and July 31, 2017. Participants underwent routine clinical investigations during their monitoring period including polysomnography, neurocognitive testing, and screening instruments of daytime somnolence, sleep quality, and quality of life. Read More

View Article
December 2018

Cortical networks are disturbed in people with cirrhosis even in the absence of neuropsychometric impairment.

Clin Neurophysiol 2018 Nov 26. Epub 2018 Nov 26.

UCL Institute for Liver & Digestive Health, Division of Medicine, Royal Free Campus, University College London, Hampstead, London, UK. Electronic address:

Objective: Hepatic encephalopathy is a common complication of cirrhosis; it is characterised by neuropsychometric/neurophysiological abnormalities. Its pathophysiology is complex but glial neuronal communication is likely to be disrupted and to impact on oscillatory networks and cortical connectivity. The aim of this study was to use multichannel electroencephalography (EEG) to investigate functional connectivity, as a surrogate for cortical networks, in patients with cirrhosis. Read More

View Article
November 2018

Psychological and electrophysiological indices of inattention in hoarding.

Psychiatry Res 2018 Dec 5;270:915-921. Epub 2018 Nov 5.

School of Psychology, University of New South Wales, Sydney, New South Wales 2052, Australia.

Individuals with elevated hoarding symptoms report elevated symptoms of ADHD and these symptoms are related to impaired daily functioning. Neuropsychological studies have found specific deficits in attention, and a recent review of attentional data from numerous hoarding studies concluded that inattention likely represents an etiological factor in hoarding, rather than a comorbidity. Our study aimed to examine which symptoms of ADHD, inattention or hyperactivity, are related to hoarding symptom severity, and whether individuals with hoarding symptoms display a neurophysiological marker of poor attention (Theta/Beta Ratio; THBR) that might explain these associations. Read More

View Article
December 2018

HLA class II expression on tumor cells and low numbers of tumor-associated macrophages predict clinical outcome in oropharyngeal cancer.

Head Neck 2018 Dec 14. Epub 2018 Dec 14.

Division of Medical Oncology, Antoni van Leeuwenhoek, The Netherlands Cancer Institute, Amsterdam, The Netherlands.

Background: Human papillomavirus (HPV)-positive oropharyngeal squamous cell carcinoma (OPSCC) is a highly immunogenic tumor and differences in tumor microenvironment might contribute to the improved survival of HPV-positive OPSCC patient.

Methods: A comprehensive multivariate analysis with clinical and immune variables (human leukocyte antigen [HLA] I/II, programmed death ligand 1 (PD-L1), programmed death receptor 1 (PD1), T cells, and macrophages) was performed in 142 OPSCC patients.

Results: We found an inverse correlation between the expression of HLA class II molecules on tumor cells and CD68+ CD163+ tumor-associated macrophages (TAMs). Read More

View Article
December 2018

Effects of antiepileptic drugs on cortical excitability in humans: A TMS-EMG and TMS-EEG study.

Hum Brain Mapp 2018 Dec 13. Epub 2018 Dec 13.

Department of Neurology & Stroke, and Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.

Brain responses to transcranial magnetic stimulation (TMS) recorded by electroencephalography (EEG) are emergent noninvasive markers of neuronal excitability and effective connectivity in humans. However, the underlying physiology of these TMS-evoked EEG potentials (TEPs) is still heavily underexplored, impeding a broad application of TEPs to study pathology in neuropsychiatric disorders. Here we tested the effects of a single oral dose of three antiepileptic drugs with specific modes of action (carbamazepine, a voltage-gated sodium channel (VGSC) blocker; brivaracetam, a ligand to the presynaptic vesicle protein VSA2; tiagabine, a gamma-aminobutyric acid (GABA) reuptake inhibitor) on TEP amplitudes in 15 healthy adults in a double-blinded randomized placebo-controlled crossover design. Read More

View Article
December 2018

Cervical Spinal Cord Stimulation for the Vegetative State: A Preliminary Result of 12 Cases.

Neuromodulation 2018 Dec 13. Epub 2018 Dec 13.

Department of Neurosurgery, West China Hospital of Sichuan University, Chengdu, China.

Objectives: Data on the treatment of the vegetative state (VS) with cervical spinal cord stimulation (cSCS) are limited and prognostic factors are inconclusive. In this study, we present our experience of treating 12 VS patients with cSCS and discuss the prognostic factors.

Methods: Twelve VS patients were enrolled. Read More

View Article
December 2018

Threat-conditioned contexts modulate the late positive potential to faces-A mobile EEG/virtual reality study.

Psychophysiology 2018 Dec 13:e13308. Epub 2018 Dec 13.

Department of Psychology, University of Marburg, Marburg, Germany.

In everyday life, the motivational value of faces is bound to the contexts in which faces are perceived. Electrophysiological studies have demonstrated that inherent negatively valent contexts modulate cortical face processing as assessed with ERP components. However, it is not well understood whether learned (rather than inherent) and three-dimensional aversive contexts similarly modulate the neural processing of faces. Read More

View Article
December 2018

Identification of a de novo splicing variant in the Coffin-Siris gene, SMARCE1, in a patient with Angelman-like syndrome.

Mol Genet Genomic Med 2018 Dec 11. Epub 2018 Dec 11.

Genetics Laboratory, UDIAT-Centre Diagnòstic, Parc Taulí Hospital Universitari, Institut d'Investigació i Innovació Parc Taulí I3PT, Universitat Autònoma de Barcelona, Sabadell, Spain.

Background: Patients affected by Angelman syndrome (AS) present severe intellectual disability, lack of speech, ataxia, seizures, abnormal electroencephalography (EEG), and a characteristic behavioral phenotype. Around 10% of patients with a clinical diagnosis of AS (AS-like) do not have an identifiable molecular defect. Some of these patients harbor alternative genetic defects that present overlapping features with AS. Read More

View Article
December 2018

Prediction error and repetition suppression have distinct effects on neural representations of visual information.

Elife 2018 Dec 14;7. Epub 2018 Dec 14.

Queensland Brain Institute, The University of Queensland, St Lucia, Australia.

Predictive coding theories argue that recent experience establishes expectations in the brain that generate when violated. Prediction errors provide a possible explanation for , where evoked neural activity is attenuated across repeated presentations of the same stimulus. The predictive coding account argues repetition suppression arises because repeated stimuli are expected, whereas non-repeated stimuli are unexpected and thus elicit larger neural responses. Read More

View Article
December 2018
1 Read

Utility of Magnetic Resonance Imaging Brain Epilepsy Protocol in New-Onset Seizures: How is it Different in Developing Countries?

J Clin Imaging Sci 2018 15;8:43. Epub 2018 Nov 15.

Department of Radiodiagnosis, Kempegowda Institute of Medical Sciences, Bengaluru, Karnataka, India.

Introduction: Magnetic resonance imaging (MRI) is the current imaging tool of choice in the investigation of patients with seizures. The advent of high-resolution MRI with a dedicated seizure protocol has significantly increased the chances of identifying a cause, resulting in a positive clinical impact on the management of these patients.

Aims: The aims of this study were to evaluate the diagnostic efficacy of standard MRI, identify whether there is an increase in the diagnostic yield with the addition of dedicated seizure protocol, and compare the diagnostic yields of MRI and electroencephalogram (EEG) individually and in combination. Read More

View Article
November 2018

Surgical strategy for temporal lobe epilepsy with dual pathology and incomplete evidence from EEG and neuroimaging.

Exp Ther Med 2018 Dec 19;16(6):4886-4892. Epub 2018 Sep 19.

Department of Neurosurgery, The Second Hospital of Dalian Medical University, Dalian, Liaoning 116000, P.R. China.

Coexistence of hippocampal sclerosis (HS) and a temporal neocortical lesion, including focal cortical dysplasia, vascular malformations or benign primary brain tumors, is defined as dual pathology. In the majority of cases, the complete evidence based on electroencephalogram (EEG) and magnetic resonance imaging (MRI) for each of the dual pathological lesions is difficult to obtain. As a result, patients with dual pathology are poor surgical candidates due to potential incomplete resection of the epileptogenic zone. Read More

View Article
December 2018

A network analysis based approach to characterizing periodic sharp wave complexes in electroencephalograms of patients with sporadic CJD.

Int J Med Inform 2019 Jan 14;121:19-29. Epub 2018 Nov 14.

Dipartimento di Scienze Mediche e Chirurgiche, University "Magna Graecia" of Catanzaro, Italy.

Creutzfeldt-Jacob disease (CJD) is a rapidly progressive, uniformly fatal transmissible spongiform encephalopathy. Sporadic CJD (sCJD) is the most common form of CJD. Electroencephalography (EEG) is one of the main methods to perform clinical diagnosis of CJD, mainly because of periodic sharp wave complexes (PSWCs). Read More

View Article
January 2019

Ictal networks of temporal lobe epilepsy: views from high-frequency oscillations in stereoelectroencephalography.

Authors:

J Neurosurg 2018 Nov 1:1-9. Epub 2018 Nov 1.

OBJECTIVEIn this study, the authors investigated high-frequency oscillation (HFO) networks during seizures in order to determine how HFOs spread from the focal cerebral cortex and become synchronized across various areas of the brain.METHODSAll data were obtained from stereoelectroencephalography (SEEG) signals in patients with drug-resistant temporal lobe epilepsy (TLE). The authors calculated intercontact cross-coefficients between all pairs of contacts to construct HFO networks in 20 seizures that occurred in 5 patients. Read More

View Article
November 2018

Effective accuracy of stereoelectroencephalography: robotic 3D versus Talairach orthogonal approaches.

Authors:

J Neurosurg 2018 Dec 1:1-9. Epub 2018 Dec 1.

OBJECTIVEStereoelectroencephalography (SEEG) was first developed in the 1950s by Jean Talairach using 2D angiography and a frame-based, orthogonal approach through a metallic grid. Since then, various other frame-based and frameless techniques have been described. In this study the authors sought to compare the traditional orthogonal Talairach 2D angiographic approach with a frame-based 3D robotic procedure that included 3D angiographic interoperative imaging guidance. Read More

View Article
December 2018

Evaluation of Electroencephalogram Using Exact Low-Resolution Electromagnetic Tomography During Photic Driving Response in Patients with Migraine.

Neuropsychobiology 2018 Dec 13:1-6. Epub 2018 Dec 13.

Department of Neurology, Dokkyo Medical University, Mibu,

Background: Photophobia is a common feature of migraine, which may involve abnormal cortical information processing. In electroencephalograms (EEG), photic driving is known as a reaction to visual stimulation. Both photophobia and photic driving response are present during light stimulation. Read More

View Article
December 2018

Parental neural responsivity to infants' visual attention: How mature brains influence immature brains during social interaction.

PLoS Biol 2018 Dec 13;16(12):e2006328. Epub 2018 Dec 13.

Cambridge University, Cambridge, United Kingdom.

Almost all attention and learning-in particular, most early learning-take place in social settings. But little is known of how our brains support dynamic social interactions. We recorded dual electroencephalography (EEG) from 12-month-old infants and parents during solo play and joint play. Read More

View Article
December 2018

Acute non-convulsive status epilepticus after experimental traumatic brain injury in rats.

J Neurotrauma 2018 Dec 13. Epub 2018 Dec 13.

University of Eastern Finalnd , Neulaniementie 2 , Kuopio, Finland , 70211 ;

Severe traumatic brain injury (TBI) induces seizures or status epilepticus (SE) in 20%-30% of patients during the acute phase. We hypothesized that severe TBI induced with lateral fluid-percussion injury (FPI) triggers post-impact SE. Adult Sprague-Dawley male rats were anesthetized with isoflurane and randomized into sham-operated experimental control or lateral FPI-induced severe TBI groups. Read More

View Article
December 2018

Prognostic evaluation of child patients with infectious encephalitis through AEEG and REEG.

Exp Ther Med 2018 Dec 19;16(6):5243-5247. Epub 2018 Oct 19.

Department of Internal Medicine, Weifang People's Hospital, Weifang, Shandong 261000, P.R. China.

This study investigated prognostic evaluation of child patients with viral encephalitis through ambulatory electroencephalogram (AEEG) and regular electroencephalogram (REEG). A total of 94 child patients who were clinically diagnosed with viral encephalitis in Yantaishan Hospital of Yantai from May 2010 to July 2014, was examined with AEEG and REEG, respectively and randomly divided into AEEG group (n=47) and REEG group (n=47). The probabilities of detecting abnormal electroencephalographic activities with two examination methods were compared. Read More

View Article
December 2018

Effects of dexmedetomidine on postoperative cognitive function in patients undergoing coronary artery bypass grafting.

Exp Ther Med 2018 Dec 19;16(6):4685-4689. Epub 2018 Sep 19.

Department of Anesthesiology, The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi 530021, P.R. China.

Effects of dexmedetomidine on postoperative cognitive function in patients undergoing coronary artery bypass grafting were investigated. Eighty patients undergoing systemic anesthesia with extracorporeal coronary artery bypass grafting in The People's Hospital of Guangxi Zhuang Autonomous Region from January 2015 to August 2017 were selected and randomly divided into the observation group (n=40) and control group (n=40). The two groups were treated with dexmedetomidine and equal volume of normal saline, respectively. Read More

View Article
December 2018

Consciousness in Neurocritical Care Cohort Study Using fMRI and EEG (CONNECT-ME): Protocol for a Longitudinal Prospective Study and a Tertiary Clinical Care Service.

Front Neurol 2018 27;9:1012. Epub 2018 Nov 27.

Department of Neurology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.

To facilitate individualized assessment of unresponsive patients in the intensive care unit for signs of preserved consciousness after acute brain injury. Physicians and neuroscientists are increasingly recognizing a disturbing dilemma: Brain-injured patients who appear entirely unresponsive at the bedside may show signs of covert consciousness when examined by functional MRI (fMRI) or electroencephalography (EEG). According to a recent meta-analysis, roughly 15% of behaviorally unresponsive brain-injured patients can participate in mental tasks by modifying their brain activity during EEG- or fMRI-based paradigms, suggesting that they are conscious and misdiagnosed. Read More

View Article
November 2018

fMRI BOLD Correlates of EEG Independent Components: Spatial Correspondence With the Default Mode Network.

Front Hum Neurosci 2018 27;12:478. Epub 2018 Nov 27.

Bender Institute of Neuroimaging, Justus Liebig University Giessen, Giessen, Germany.

: We aimed to identify electroencephalographic (EEG) signal fluctuations within independent components (ICs) that correlate to spontaneous blood oxygenation level dependent (BOLD) activity in regions of the default mode network (DMN) during eyes-closed resting state. : We analyzed simultaneously acquired EEG and functional magnetic resonance imaging (fMRI) eyes-closed resting state data in a convenience sample of 30 participants. IC analysis (ICA) was used to decompose the EEG time-series and common ICs were identified using data-driven IC clustering across subjects. Read More

View Article
November 2018

No Effect of Transcranial Direct Current Stimulation of the Auditory Cortex on Auditory-Evoked Potentials.

Front Neurosci 2018 27;12:880. Epub 2018 Nov 27.

Division of Systems Neuroscience of Psychopathology, Translational Research Center, University Hospital of Psychiatry Bern, Bern, Switzerland.

Transcranial direct current stimulation (tDCS) is a non-invasive brain stimulation technique to change cortical excitability. Its effects are shown for cognitive processing, and behavior in the motor and perceptual domains. However, evidence of tDCS effects in the perceptual domain particularly for auditory processing is rare. Read More

View Article
November 2018

Imbalance of Functional Connectivity and Temporal Entropy in Resting-State Networks in Autism Spectrum Disorder: A Machine Learning Approach.

Front Neurosci 2018 27;12:869. Epub 2018 Nov 27.

Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, United States.

Two approaches to understanding the etiology of neurodevelopmental disorders such as Autism Spectrum Disorder (ASD) involve network level functional connectivity (FC) and the dynamics of neuronal signaling. The former approach has revealed both increased and decreased FC in individuals with ASD. The latter approach has found high frequency EEG oscillations and higher levels of epilepsy in children with ASD. Read More

View Article
November 2018

Antiepileptic Drug of Levetiracetam Decreases Centrotemporal Spike-Associated Activation in Rolandic Epilepsy.

Front Neurosci 2018 27;12:796. Epub 2018 Nov 27.

Department of Medical Imaging, Jinling Hospital, Southern Medical University, Nanjing, China.

The objective was to study the modulation effects of levetiracetam on the fMRI activation/deactivation patterns associated with centrotemporal spikes (CTS) in Rolandic epilepsy. Forty patients with Rolandic epilepsy, including levetiracetam-medicated patients ( = 20) and drug-naive patients ( = 20), were studied. Single and sequential hemodynamic response functions-based EEG-fMRI analysis was performed to detect dynamic activation/deactivation associated with CTS. Read More

View Article
November 2018

The role of meaning in visual memory: Face-selective brain activity predicts memory for ambiguous face stimuli.

J Neurosci 2018 Dec 12. Epub 2018 Dec 12.

Department of Psychology, University of California, San Diego, La Jolla, CA, 92093, USA.

How people process images is known to affect memory for those images, but these effects have typically been studied using explicit task instructions to vary encoding. Here, we investigate the effects of intrinsic variation in processing on subsequent memory, testing whether recognizing an ambiguous stimulus as meaningful (as a face vs. as shape blobs) predicts subsequent visual memory even when matching the perceptual features and the encoding strategy between subsequently remembered and subsequently forgotten items. Read More

View Article
December 2018

Right temporal alpha oscillations as a neural mechanism for inhibiting obvious associations.

Proc Natl Acad Sci U S A 2018 Dec 12. Epub 2018 Dec 12.

Department of Psychology, Goldsmiths, University of London, London SE14 6NW, United Kingdom.

Creative cognition requires mental exploration of remotely connected concepts while suppressing dominant ones. Across four experiments using different samples of participants, we provide evidence that right temporal alpha oscillations play a crucial role in inhibiting habitual thinking modes, thereby paving the way for accessing more remote ideas. In the first experiment, participants completed the compound remote associate task (RAT) in three separate sessions: during right temporal alpha (10 Hz) transcranial alternating current brain stimulation (tACS), left temporal alpha tACS, and sham tACS. Read More

View Article
December 2018

encephalopathy: A distinctive generalized developmental and epileptic encephalopathy.

Neurology 2018 Dec 12. Epub 2018 Dec 12.

From the Epilepsy Research Centre (D.R.M.V., B.J.S., R.B., M.F.B., S.F.B., M.S.H., I.E.S.), Department of Medicine, University of Melbourne, Austin Health, Australia; Departments of Genetics (D.R.M.V., C.M.A.v.R.-A.) and Neurology (D.R.M.V.), University Medical Center Groningen, University of Groningen, the Netherlands; Pediatric Neurology Unit and Laboratories (D.M., M.M.) and Pediatric Neurology (R.G.), Neurogenetics and Neurobiology Unit and Laboratories, A. Meyer Children's Hospital, University of Florence, Italy; Department of Pediatrics and Pediatric Epilepsy Centre (H.X., W.X.W., Y.J.), Peking University First Hospital, Beijing, China; Department of Pediatrics (C.T.M., H.C.M.), Division of Genetic Medicine, University of Washington, Seattle; Population Health and Immunity Division (M.F.B.), Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia; Department of Medical Biology (M.F.B.), University of Melbourne, Australia; Caulfield (D.W.), Melbourne, Australia; Department of Clinical Genetics (S.M.M.), Academic Medical Centre, Amsterdam, the Netherlands; Department of Clinical Genetics (A.S.B., G.M.S.M., I.M.B.H.v.d.L.), Erasmus University Medical Centre, Rotterdam, the Netherlands; Department of Clinical Genetics (J.M.v.H.), VU University Medical Center, Amsterdam, the Netherlands; Tasmanian Health Service (T.L.W.), Women's and Children's Services, Launceston General Hospital, Tasmania, Australia; TY Nelson Department of Neurology and Neurosurgery (R.I.W.) and Institute of Neuroscience and Muscle Research (R.I.W.), Children's Hospital at Westmead, Sydney, New South Wales, Australia; Department of Neurosciences (S.M.), Lady Cilento Children's Hospital, Brisbane, Australia; Department of Anatomical Pathology (R.M.K.), Austin Hospital, Melbourne, Australia; IRCCS Stella Maris Foundation (F.S., R.G.), Pisa, Italy; Klinikum Oldenburg (G.C.K.), Zentrum für Kinder-und Jugendmedizin, Klinik für Neuropädiatrie u.angeborene Stoffwechselerkrankungen, Germany; Centre of Epilepsy (Y.J.), Beijing Institute for Brain Disorders, China; Department of Paediatrics (I.E.S.), University of Melbourne, Royal Children's Hospital, Australia; and Florey Institute of Neurosciences and Mental Health (I.E.S.), Australia.

Objective: To delineate the epileptology, a key part of the phenotypic spectrum, in a large patient cohort.

Methods: Patients were recruited via investigators' practices or social media. We included patients with (likely) pathogenic variants or chromosome 6p21. Read More

View Article
December 2018
2 Reads

Developmental differences in the neural correlates supporting semantics and syntax during sentence processing.

Dev Sci 2018 Dec 7:e12782. Epub 2018 Dec 7.

The University of Texas at Dallas.

School-aged and adolescent children continue to demonstrate improvements in how they integrate and comprehend real-time, auditory language over this developmental time period, which can have important implications for academic and social success. To better understand developmental changes in the neural processes engaged during language comprehension in this age group, we use electroencephalography (EEG) to investigate how 8-9 year old, 12-13 year olds, and adults process semantics and syntax in naturally-paced, auditory sentences. Participants listened to semantically and syntactically correct and incorrect sentences and were asked to complete an acceptability judgment task. Read More

View Article
December 2018

Quantitative analysis and EEG markers of KCNT1 epilepsy of infancy with migrating focal seizures.

Epilepsia 2018 Dec 7. Epub 2018 Dec 7.

INSERM Unit U1129 Infantile Epilepsies and Brain Plasticity, University Paris Descartes, Sorbonne Paris Cité, Paris, France.

Objective: We aimed to characterize epilepsy of infancy with migrating focal seizures (EIMFS), a rare, severe early onset developmental epilepsy related to KCNT1 mutation, and to define specific electroencephalography (EEG) markers using EEG quantitative analysis. The ultimate goal would be to improve early diagnosis and to better understand seizure onset and propagation of EIMFS as compared to other early onset developmental epilepsy.

Methods: EEG of 7 EIMFS patients with KCNT1 mutations (115 seizures) and 17 patients with other early onset epilepsies (30 seizures) was included in this study. Read More

View Article
December 2018

Running-down phenomenon captured with chronic electrocorticography.

Epilepsia Open 2018 Dec 19;3(4):528-534. Epub 2018 Oct 19.

Department of Neurology NYU School of Medicine New York New York U.S.A.

The running-down phenomenon refers to 2 analogous but distinct entities that may be seen after epilepsy surgery. The first is clinical, and denotes a progressive diminution in seizures after epilepsy surgery in which the epileptogenic zone could not be completely removed (Modern Problems of Psychopharmacology 1970;4:306, Brain 1996:989). The second is electrographic, and refers to a progressive deactivation of a secondary seizure focus after removal of the primary epileptogenic zone. Read More

View Article
December 2018

A retrospective observational study of EEG findings and antiepileptic drug use among children referred for EEG to Zambia's University Teaching Hospital.

Epilepsia Open 2018 Dec 16;3(4):503-510. Epub 2018 Oct 16.

Epilepsy Division Department of Neurology University of Rochester Rochester New York U.S.A.

Objective: Despite the heavy burden of epilepsy in Sub-Saharan Africa, there remains a relative paucity of neurophysiology services and limited published data on electroencephalography (EEG) features among African children. The aim of this study was to describe clinical characteristics, EEG findings, and antiepileptic drug (AED) use among children referred for EEG to the University Teaching Hospital in Zambia.

Methods: EEG referrals and reports from 2013-2015 were reviewed. Read More

View Article
December 2018

mutations cause variable phenotypes of developmental and epileptic encephalopathy.

Epilepsia Open 2018 Dec 1;3(4):495-502. Epub 2018 Nov 1.

Department of Pediatrics Showa University School of Medicine Shinagawa-ku, Tokyo Japan.

Objective: Vitamin B-dependent epilepsies are treatable disorders caused by variants in several genes, such as ,, and others. Recently, biallelic variants in formerly known as , were identified as a novel cause of vitamin B-dependent epilepsies. Our objective was to further delineate the phenotype of mutation. Read More

View Article
December 2018

Unravelling the brain networks driving spike-wave discharges in genetic generalized epilepsy-common patterns and individual differences.

Epilepsia Open 2018 Dec 23;3(4):485-494. Epub 2018 Aug 23.

Department of Neurology and Epileptology Hertie-Institute for Clinical Brain Research University of Tübingen Tübingen Germany.

Objective: Genetic generalized epilepsies (GGEs) are characterized by generalized spike-wave discharges (GSWDs) in electroencephalography (EEG) recordings without underlying structural brain lesions. The origin of the epileptic activity remains unclear, although several studies have reported involvement of thalamus and default mode network (DMN). The aim of the current study was to investigate the networks involved in the generation and temporal evolution of GSWDs to elucidate the origin and propagation of the underlying generalized epileptic activity. Read More

View Article
December 2018

Methodologic recommendations and possible interpretations of video-EEG recordings in immature rodents used as experimental controls: A TASK1-WG2 report of the ILAE/AES Joint Translational Task Force.

Epilepsia Open 2018 Dec 11;3(4):437-459. Epub 2018 Oct 11.

Laboratory of Developmental Epilepsy Saul R. Korey Department of Neurology Dominick P. Purpura Department of Neuroscience Isabelle Rapin Division of Child Neurology Albert Einstein College of Medicine Einstein/Montefiore Epilepsy Center Montefiore Medical Center Bronx New York U.S.A.

The use of immature rodents to study physiologic aspects of cortical development requires high-quality recordings electroencephalography (EEG) with simultaneous video recording (vEEG) of behavior. Normative developmental vEEG data in control animals are fundamental for the study of abnormal background activity in animal models of seizures or other neurologic disorders. Electrical recordings from immature, freely behaving rodents can be particularly difficult because of the small size of immature rodents, their thin and soft skull, interference with the recording apparatus by the dam, and other technical challenges. Read More

View Article
December 2018

Artificial Immune System-Negative Selection Classification Algorithm (NSCA) for Four Class Electroencephalogram (EEG) Signals.

Front Hum Neurosci 2018 20;12:439. Epub 2018 Nov 20.

Department of Mechatronics Engineering, National University of Sciences & Technology, Islamabad, Pakistan.

Artificial immune systems (AIS) are intelligent algorithms derived from the principles inspired by the human immune system. In this study, electroencephalography (EEG) signals for four distinct motor movements of human limbs are detected and classified using a negative selection classification algorithm (NSCA). For this study, a widely studied open source EEG signal database (BCI IV-Graz dataset 2a, comprising nine subjects) has been used. Read More

View Article
November 2018

Tracking Feature-Based Attention.

J Neural Eng 2018 Oct 31. Epub 2018 Oct 31.

Department of Cognitive Sciences, University of California Irvine, UC Irvine, CA 92697-5100, USA, Irvine, 92697, UNITED STATES.

Objective: Feature-based attention (FBA) helps one detect objects with a particular color, motion, or orientation. FBA works globally; the attended feature is enhanced at all positions in the visual field. This global property of FBA lets one use stimuli presented in the peripheral visual field to track attention in a task presented centrally. Read More

View Article
October 2018

Feature relevance in physiological networks for classification of obstructive sleep apnea.

Physiol Meas 2018 Nov 14. Epub 2018 Nov 14.

Center for Biomedical Image and Information Processing, University of Applied Sciences Berlin, Berlin, GERMANY.

Objective: Physiological networks (PN) model couplings between organs in a high- dimensional parameter space. Machine learning methods, in particular artifical neural networks (ANNs), are powerful on high-dimensional classification tasks. However, lack of interpretability of the resulting models has been a drawback in research. Read More

View Article
November 2018

Inter-subject transfer learning with end-to-end deep convolutional neural network for EEG-based BCI.

J Neural Eng 2018 Nov 26. Epub 2018 Nov 26.

School of Computer Science and Engineering, Nanyang Technological University, Singapore, Singapore, SINGAPORE.

Objective: Despite the effective application of deep learning in brain-computer interface (BCI) systems, the successful execution of this technique especially for inter-subject classification in cognitive BCI has not been accomplished yet. In this paper, we propose a framework based on deep convolutional neural network (CNN) to detect attentive mental state from single-channel raw electroencephalography (EEG) data.

Approach: We develop an end-to-end deep CNN to decode the attentional information from EEG time-series. Read More

View Article
November 2018

Combination of high-frequency SSVEP-based BCI and computer vision for controlling a robotic arm.

J Neural Eng 2018 Dec 3. Epub 2018 Dec 3.

Department of Biomedical Engineering School of Medicine, Tsinghua University, Beijing 100084, PR CHINA, Beijing, CHINA.

Objective: Recent attempts in developing brain-computer interface (BCI)-controlled robots have shown the potential of this area in the field of assistive robots. However, implementing the process of objects picking and placing using BCI-controlled robotic arm still remains challenging. BCI performance, system portability, and user comfortableness need to be further improved. Read More

View Article
December 2018

Neural correlates of speech quality dimensions analyzed using electroencephalography (EEG).

J Neural Eng 2018 Nov 15. Epub 2018 Nov 15.

Quality and Usability Lab, Technische Universitat Berlin Fakultat IV Elektrotechnik und Informatik, Ernst-Reuter-Platz 7, TEL-18 /QULab, Berlin, Berlin, 10587, GERMANY.

Objective: By means of subjective psychophysical methods, quality of transmitted speech has been decomposed into three perceptual dimensions named "discontinuity" (F), "noisiness" (N) and "coloration" (C). Previous studies using electroencephalography (EEG) already reported effects of perceived intensity of single quality dimensions on electrical brain activity. However, it has not been investigated so far, whether the dimensions themselves are dissociable on a electrophysiological level of analysis. Read More

View Article
November 2018

A comprehensive review of EEG-based brain-computer interface paradigms.

J Neural Eng 2018 Nov 15. Epub 2018 Nov 15.

Mechanical, Aerospace and Biomedical Engineering, University of Tennessee, Knoxville, TN 37996-2210, USA, Knoxville, Tennessee, UNITED STATES.

Advances in brain science and computer technology in the past decade have led to exciting developments in Brain-Computer Interface (BCI), thereby making BCI a top research area in applied science. The renaissance of BCI opens new methods of neurorehabilitation for physically disabled people (e.g. Read More

View Article
November 2018