Search Our Scientific Publications & Authors

Brain Sci 2020 Jun 23;10(6). Epub 2020 Jun 23.

Section for Experimental Neuropsychiatry, Department of Psychiatry and Psychotherapy, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, 79104 Freiburg, Germany.

Atypical Parkinsonian syndromes with prominent frontal lobe involvement can occur in the 4R-taupathies progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD). Secondary forms of movement disorders may occur in the context of autoimmune encephalitis with antineuronal antibodies, such as anti-glycine receptor (anti-GlyR) antibodies, which are typically associated with Stiff-Person spectrum syndrome, or progressive encephalomyelitis with rigidity and myoclonus. Overlaps between neurodegenerative and immunological mechanisms have been recently suggested in anti-IgLON5 disease. Read More

Case Rep Neurol Med 2020 2;2020:5269352. Epub 2020 Jun 2.

Department of Neurology, SUNY Upstate Medical University Hospital, 750 E Adams St., Syracuse, NY 13210, USA.

Introduction: Paraneoplastic limbic encephalitis (PLE) is a rare disease that presents as rapid onset dementia characterized by short-term memory loss (STM), anxiety, and behavioral changes. Anti-NMDAR antibodies are unfrequently reported in PLE associated with small-cell lung cancer (SCLC). Given that PLE can precede the diagnosis of cancer, it is very important that once infectious, metabolic, nutritional, or structural disorders associated with short-term memory loss are ruled out that vigorous effort must be made to rule out underlying malignancy. Read More

Psychiatry Res Neuroimaging 2020 May 17;302:111099. Epub 2020 May 17.

Division of Clinical Geriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden. Electronic address:

Cholinergic dysfunction is central in Alzheimer's disease (AD) and dementia with Lewy bodies (DLB). The electroencephalography-based acetylcholine index (EEG-Ach index) has been proposed as a biomarker of cholinergic dysfunction. However, it is unclear how the EEG-Ach index relates to amyloid-beta pathology and neurodegeneration. Read More

J Clin Neurophysiol 2020 May 26. Epub 2020 May 26.

Department of Neurology, Zentrum für Ambulante Rehabilitation, Kaiserslautern, Germany.

Purpose: Subcortical arteriosclerotic encephalopathy (SAE) is characterized by extensive white matter lesions in the MRI. Clinical symptoms are cognitive impairment, ranging from mild deficits to vascular dementia, impaired executive functioning, and gait disorders. In the EEG of SAE patients with vascular dementia, the lower frequencies are increased. Read More

Front Hum Neurosci 2020 7;14:155. Epub 2020 May 7.

Department of Neurology, Danish Dementia Research Centre, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.

Exercise has been shown to alter brain plasticity and is explored as a therapeutic intervention in a wide variety of neurological diseases. Electroencephalography (EEG) offers an inexpensive method of studying brain electrocortical activity shortly after exercise and thus offers a way of exploring the influence of exercise on the brain. We conducted a systematic review to summarize the current body of evidence regarding methods of EEG analysis and the reported effects of exercise interventions on EEG. Read More

Ann Neurol 2020 May 17. Epub 2020 May 17.

Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.

Coronavirus disease 2019 (COVID-19) infection has the potential for targeting the central nervous system, and several neurological symptoms have been described in patients with severe respiratory distress. Here, we described the case of a 60-year-old patient with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection but only mild respiratory abnormalities who developed an akinetic mutism attributable to encephalitis. Magnetic resonance imaging was negative, whereas electroencephalography showed generalized theta slowing. Read More

Clin EEG Neurosci 2020 May 13:1550059420917842. Epub 2020 May 13.

Johns Hopkins Bayview Medical Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Generalized periodic discharges with triphasic morphology (GPDs + TWm) have been reported with multiple metabolic and drug toxicities. Beta-lactam antibiotics in some cases can cause neurotoxicity with GPDs + TWm on EEG. There are no reports in the literature of aztreonam causing neurotoxicity and GPDs + TWm. Read More

Brain 2020 Jun;143(6):1889-1904

Dementia Research Centre and Department of Biomedical Sciences, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, 2109, NSW, Australia.

Hyperphosphorylation and deposition of tau in the brain characterizes frontotemporal dementia and Alzheimer's disease. Disease-associated mutations in the tau-encoding MAPT gene have enabled the generation of transgenic mouse models that recapitulate aspects of human neurodegenerative diseases, including tau hyperphosphorylation and neurofibrillary tangle formation. Here, we characterized the effects of transgenic P301S mutant human tau expression on neuronal network function in the murine hippocampus. Read More

Int J Psychophysiol 2020 Apr 27;155:9-15. Epub 2020 Apr 27.

Department of Cognitive Neuropsychology, Tilburg University, Tilburg, the Netherlands.

Introduction: Life expectancy in the US is 78.6 years, and although people are living longer, they are also living with chronic diseases. As women age, they are more susceptible to chronic disease including mental health conditions and Alzheimer's Disease (AD) dementia. Read More

J Med Life 2020 Jan-Mar;13(1):8-15

"RoNeuro" Institute for Neurological Research and Diagnostic, Cluj-Napoca, Romania.

Quantitative electroencephalography (QEEG) is a modern type of electroencephalography (EEG) analysis that involves recording digital EEG signals which are processed, transformed, and analyzed using complex mathematical algorithms. QEEG has brought new techniques of EEG signals feature extraction: analysis of specific frequency band and signal complexity, analysis of connectivity, and network analysis. The clinical application of QEEG is extensive, including neuropsychiatric disorders, epilepsy, stroke, dementia, traumatic brain injury, mental health disorders, and many others. Read More

CNS Spectr 2020 Apr;25(2):310-311

Assistant Professor Of Psychiatry, Campbell University Of Osteopathic School Of Medicine; Fayetteville, NC.

The term Catatonia was coined by Kraepelin in 1893 and was categorized as a subtype of dementia praecox. Bleuler in 1906 redefined it as catatonic Schizophrenia. Over the period of time by accumulating evidence of various case reports and studies its apparent that catatonia is not only seen in Schizophrenia, Affective disorders but is also seen secondary to various medical problems. Read More

Front Neurosci 2020 31;14:239. Epub 2020 Mar 31.

Institute of Cognitive Neurology and Dementia Research, Otto von Guericke University Magdeburg, Magdeburg, Germany.

Cognitive functions, such as working memory (WM) and attention, have been shown to benefit from physical exercise. Quantifying frequency-band-specific neural oscillatory patterns during the use of such cognitive functions can provide insight into exercise-induced benefits in the brain. Specifically, we investigated whether a 4-month physical exercise training influenced theta and alpha power measured in visual WM and attention tasks. Read More

Cureus 2020 Mar 8;12(3):e7211. Epub 2020 Mar 8.

Neurology, Saint Louis University Hospital, St. Louis, USA.

Creutzfeldt-Jakob disease (CJD) is the most common human prion disease presenting with subacute cognitive decline. Common MRI findings for CJD include the T2 prolongation signal of the putamen and head of caudate. Diffusion-weighted MRI (DW-MRI) is considered to be the most sensitive technique for the detection of CJD-related abnormalities, especially for cortical changes. Read More

Int J Psychophysiol 2020 Jun 30;152:15-25. Epub 2020 Mar 30.

Experimental Psychology Lab, Department of Psychology, Cluster for Excellence "Hearing for All", European Medical School, Carl von Ossietzky University, Oldenburg, Germany; Neuroimaging Unit, European Medical School, Carl von Ossietzky University, Oldenburg, Germany; Research Center Neurosensory Science, Carl von Ossietzky University Oldenburg, Germany. Electronic address:

Gamma oscillations (30-80 Hz) are well-known for their role in cortical signal transmission and cognitive brain functions. Aberrant gamma activity has been observed in various neuropsychiatric disorders, but the clinical potential of restoring gamma oscillations via noninvasive brain stimulation has been widely neglected. Only recently, therapeutic effects of gamma entrainment were documented in mouse models of Alzheimer's dementia (AD) using rhythmic sensory stimulation. Read More

Transl Psychiatry 2020 Mar 20;10(1):100. Epub 2020 Mar 20.

Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

This review summarizes the last decade of work by the ENIGMA (Enhancing NeuroImaging Genetics through Meta Analysis) Consortium, a global alliance of over 1400 scientists across 43 countries, studying the human brain in health and disease. Building on large-scale genetic studies that discovered the first robustly replicated genetic loci associated with brain metrics, ENIGMA has diversified into over 50 working groups (WGs), pooling worldwide data and expertise to answer fundamental questions in neuroscience, psychiatry, neurology, and genetics. Most ENIGMA WGs focus on specific psychiatric and neurological conditions, other WGs study normal variation due to sex and gender differences, or development and aging; still other WGs develop methodological pipelines and tools to facilitate harmonized analyses of "big data" (i. Read More

PLoS One 2020 12;15(3):e0229950. Epub 2020 Mar 12.

Department of Applied Mathematics, Northwestern Polytechnical University, Xi'an, PR China.

A decrease in alpha band power is defined as a hallmark of electroencephalogram (EEG) in Alzheimer's disease (AD). This study devotes to understanding the neuronal correlates of alpha rhythm slowing associated with AD from the view of neurocomputation. Firstly, a modified computational model of thalamo-cortico-thalamic (TCT) circuitry is constructed by incorporating two important biologically plausible ingredients. Read More

PLoS One 2020 11;15(3):e0230277. Epub 2020 Mar 11.

Center for Neuroscience, Korea Institute of Science and Technology, Seoul, Republic of Korea.

The amyloid-β (Aβ) oligomer is considered one of the major pathogens responsible for neuronal and synaptic loss in Alzheimer's disease (AD) brains. Although the neurotoxic mechanisms of Aβ have been widely investigated, experimental evidence for the direct linkage between neural signaling and cognitive impairments in association with peptide oligomers is lacking. Here, we conducted an auditory oddball paradigm utilizing an Aβ-infused Alzheimer's disease mouse model and interpreted the results based on Y-maze behavioral tests. Read More

Isr Med Assoc J 2020 Mar;22(3):178-184

Department of Radiology, New York University Langone Medical Center, New York, NY, USA.

Background: The authors reviewed the two most common current uses of brain 18F-labeled fluoro-2-deoxyglucose positron emission tomography (FDG-PET) at a large academic medical center. For epilepsy patients considering surgical management, FDG-PET can help localize epileptogenic lesions, discriminate between multiple or discordant EEG or MRI findings, and predict prognosis for post-surgical seizure control. In elderly patients with cognitive impairment, FDG-PET often demonstrates lobar-specific patterns of hypometabolism that suggest particular underlying neurodegenerative pathologies, such as Alzheimer's disease. Read More

BMC Neurol 2020 Feb 11;20(1):51. Epub 2020 Feb 11.

Department of Neurology, Mianyang Central Hospital, Changjia Alley 12#, Fucheng district, Mianyang City, 621000, Sichuan, China.

Background: Nonconvulsive status epilepticus (NCSE) is a state of ongoing seizure activity without convulsions. The heterogeneous and subtle clinical features of NCSE make diagnosis and treatment challenging. Here, we report a patient with NCSE who showed a main presenting symptom of acute visual impairment, which is a rare and atypical clinical symptom of NCSE. Read More

Conf Proc IEEE Eng Med Biol Soc 2019 07;2019:6434-6437

The aim of this study was to evaluate the effect of volume conduction on different connectivity metrics: Amplitude Envelope Correlation (AEC), Phase Lag Index (PLI), and Magnitude Squared Coherence (MSCOH). These measures were applied to: (i) a synthetic model of 64 coupled oscillators; and (ii) a resting-state EEG database of 72 patients with dementia due to Alzheimer's disease (AD) and 37 cognitively healthy controls. Our results revealed that AEC and PLI are weakly influenced by the simulated volume conduction compared to MSCOH, although the three metrics are not immune to this effect. Read More

Conf Proc IEEE Eng Med Biol Soc 2019 07;2019:5786-5789

The main objective of this study was to characterize EEG resting-state activity in 55 Alzheimer's disease (AD) patients and 29 healthy controls by means of TREND, a measure based on recurrence quantification analysis. TREND was computed from 60-second recordings of consecutive EEG activity, divided into non-overlapping windows of length 1, 2, 3, 5, 10, 15, 20 and 60 seconds. This measure was computed in the conventional EEG frequency bands (delta, theta, alpha, beta-1, beta-2 and gamma). Read More

Conf Proc IEEE Eng Med Biol Soc 2019 07;2019:4400-4403

Gastrin-releasing peptide (GRP) has been confirmed to exhibit a variety of physiological functions in the brain and play a role in many neurological diseases. Our previous research found that GRP could restore the impaired synaptic plasticity and the spatial learning and memory impairments induced by vascular dementia (VD). However, the specific mechanisms of GRP affecting hippocampus, especially the effects on the neuronal oscillations were still poorly understood. Read More

Neural Netw 2020 Mar 14;123:176-190. Epub 2019 Dec 14.

DICEAM, University Mediterranea of Reggio Calabria, Via Graziella, Feo di Vito, 89060 Reggio Calabria, Italy. Electronic address:

Electroencephalographic (EEG) recordings generate an electrical map of the human brain that are useful for clinical inspection of patients and in biomedical smart Internet-of-Things (IoT) and Brain-Computer Interface (BCI) applications. From a signal processing perspective, EEGs yield a nonlinear and nonstationary, multivariate representation of the underlying neural circuitry interactions. In this paper, a novel multi-modal Machine Learning (ML) based approach is proposed to integrate EEG engineered features for automatic classification of brain states. Read More

Am J Case Rep 2019 Dec 16;20:1883-1887. Epub 2019 Dec 16.

Department of Nuclear Medicine and Radiology, Institute of Development, Aging, and Cancer, Tohoku University, Sendai, Miyagi, Japan.

BACKGROUND The diagnosis of early non-convulsant status epilepticus (NCSE) can be challenging and can overlap with other critical conditions. Two patients with Alzheimer's disease are reported with clinically suspected NCSE presenting in the emergency setting who were diagnosed using arterial spin-labeling magnetic resonance imaging (ASL-MRI) sequences. CASE REPORT In Case 1, a 69-year-old woman with mild Alzheimer's disease and diabetes presented with acute worsening of cognitive status and fluctuating level of consciousness. Read More

Arq Neuropsiquiatr 2019 11;77(11):815-824

Universidade de São Paulo, Faculdade de Medicina, Hospital das Clínicas, Departamento de Neurologia, Grupo de Neurologia Cognitiva e do Comportamento, São Paulo SP, Brasil.

The association between Alzheimer's disease (AD) and sleep disturbances has received increasing scientific attention in the last decades. However, little is known about the impact of sleep and its disturbances on the development of preclinical AD stages, such as mild cognitive impairment. This review describes the evolution of knowledge about the potential bidirectional relationships between AD and sleep disturbances exploring recent large prospective studies and meta-analyses and studies of the possible mechanisms through which sleep and the neurodegenerative process could be associated. Read More

Hum Brain Mapp 2020 Apr 9;41(6):1573-1590. Epub 2019 Dec 9.

Institute of Neuroscience, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, UK.

The diagnosis of dementia with Lewy bodies (DLB) versus Alzheimer's disease (AD) can be difficult especially early in the disease process. However, one inexpensive and non-invasive biomarker which could help is electroencephalography (EEG). Previous studies have shown that the brain network architecture assessed by EEG is altered in AD patients compared with age-matched healthy control people (HC). Read More

Nat Commun 2019 11 22;10(1):5322. Epub 2019 Nov 22.

McGill University & Douglas Mental Health University Institute, Montreal, Canada.

Slow gamma oscillations (30-60 Hz) correlate with retrieval of spatial memory. Altered slow gamma oscillations have been observed in Alzheimer's disease. Here, we use the J20-APP AD mouse model that displays spatial memory loss as well as reduced slow gamma amplitude and phase-amplitude coupling to theta oscillations phase. Read More

Trials 2019 Nov 20;20(1):632. Epub 2019 Nov 20.

Institut du Cerveau et de la Moelle Epinière, ICM, INSERM U 1127, CNRS UMR 7225, Sorbonne Université, Frontlab team, Paris, France.

Background: Semantic dementia is a neurodegenerative disease that primarily affects the left anterior temporal lobe, resulting in a gradual loss of conceptual knowledge. There is currently no validated treatment. Transcranial stimulation has provided evidence for long-lasting language effects presumably linked to stimulation-induced neuroplasticity in post-stroke aphasia. Read More

Int J Environ Res Public Health 2019 11 6;16(22). Epub 2019 Nov 6.

Korea Institute of Oriental Medicine, Daejeon 34054, Korea.

We aimed to develop forest therapy programs (FTPs) to prevent dementia and related health problems in the elderly population, with the assumption that health benefits are FTP-type specific and depend on the participant's psychophysiological traits. For this purpose, we developed two distinct FTPs, namely, a guided-breathing meditation program (BP) and a walking program (WP); we adopted the approach of Sasang constitutional (SC) medicine, which categorizes individuals into one of three SC types (SC1, SC2, or SC3) for medical care. The FTPs ran 11 sessions over 11 weeks. Read More

Trop Doct 2020 Jan 6;50(1):81-83. Epub 2019 Nov 6.

Professor and Head, Department of Medicine, Dr. TMA Pai Hospital (Udupi), Melaka Manipal Medical College, Manipal Academy of Higher Education, Manipal, India.

Dengue infection can cause various effects on the central and peripheral nervous systems. Direct neurotropism and immunological mechanisms are responsible for most such neurological manifestations. We present the case of a 64-year-old woman with rapidly progressive dementia with seizures following dengue infection. Read More

Photobiomodul Photomed Laser Surg 2019 Oct;37(10):623-634

CNDD, Hanover, Pennsylvania.

A review of photobiomodulation (PBM) in Alzheimer's dementia is submitted. The addition of PBM in neurodegenerative diseases is a dual modality that is at present gaining traction as it is safe, antiviral, and anti-inflammatory for treating neurodegeneration with photons that stimulate mitochondria increasing adenosine triphosphate and proteasomes increasing misfolded protein removal. Neurofeedback provides neural plasticity with an increase in brain-derived nerve factor mRNA and an increase in dendrite production and density in the hippocampus coupled with overall growth in dendrites, density, and neuronal survival. Read More

J Neurosci 2019 11 22;39(48):9645-9659. Epub 2019 Oct 22.

Centenary Institute, University of Sydney, Camperdown 2006, New South Wales, Australia,

Sphingosine 1-phosphate (S1P) is a potent vasculoprotective and neuroprotective signaling lipid, synthesized primarily by sphingosine kinase 2 (SK2) in the brain. We have reported pronounced loss of S1P and SK2 activity early in Alzheimer's disease (AD) pathogenesis, and an inverse correlation between hippocampal S1P levels and age in females, leading us to speculate that loss of S1P is a sensitizing influence for AD. Paradoxically, SK2 was reported to mediate amyloid β (Aβ) formation from amyloid precursor protein (APP) To determine whether loss of S1P sensitizes to Aβ-mediated neurodegeneration, we investigated whether SK2 deficiency worsens pathology and memory in male J20 (PDGFB-APP) mice. Read More

Nat Commun 2019 10 16;10(1):4699. Epub 2019 Oct 16.

Department of Developmental Physiology, National Institute for Physiological Sciences, 38 Nishigonaka, Myodaiji, Okazaki, Aichi, 444-8585, Japan.

Regaining the function of an impaired limb is highly desirable in paralyzed individuals. One possible avenue to achieve this goal is to bridge the interrupted pathway between preserved neural structures and muscles using a brain-computer interface. Here, we demonstrate that monkeys with subcortical stroke were able to learn to use an artificial cortico-muscular connection (ACMC), which transforms cortical activity into electrical stimulation to the hand muscles, to regain volitional control of a paralysed hand. Read More

N Engl J Med 2019 Oct;381(16):1569-1578

From the Departments of Neurology (B.K.C., J.D.S.), Radiology (B.R.B.), and Pathology (W.R.S.), Massachusetts General Hospital, and the Departments of Neurology (B.K.C., J.D.S.), Radiology (B.R.B.), and Pathology (W.R.S.), Harvard Medical School - both in Boston.

BMJ Case Rep 2019 Sep 24;12(9). Epub 2019 Sep 24.

Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia.

Antemortem assessment of sporadic Creutzfeldt-Jakob disease (sCJD) can be significantly hampered due to its rarity, low index of clinical suspicion and its non-specific clinical features. We present an atypical case of definitive sCJD. The patient died within 5 weeks of the disease onset. Read More

Clin Neurophysiol 2019 11 28;130(11):2053-2059. Epub 2019 Aug 28.

Department of Neurology, Ulm University Hospital, Ulm, Germany. Electronic address:

Objective: A sensorimotor network structural phenotype predicted motor task performance in a previous study in Huntington's disease (HD) gene carriers. We investigated in the visual network whether structure - function - behaviour relationship patterns, and the effects of the HD mutation, extended beyond the sensorimotor network.

Methods: We used multimodal visual network MRI structural measures (cortical thickness and white matter connectivity), plus visual evoked potentials and task performance (Map Search; Symbol Digit Modalities Test) in healthy controls and HD gene carriers. Read More

Clin Neurophysiol 2019 11 26;130(11):2038-2052. Epub 2019 Aug 26.

Cognitive Neuroscience Section, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy.

Objective: To investigate whether anodal and cathodal transcranial direct current stimulation (tDCS) can modify cognitive performance and neural activity in healthy elderly and Alzheimer's disease (AD) patients.

Methods: Fourteen healthy elderly and twelve AD patients performed a working memory task during an electroencephalogram recording before and after receiving anodal, cathodal, and sham tDCS over the left dorsolateral prefrontal cortex. Behavioural performance, event-related potentials (P200, P300) and evoked cortical oscillations were studied as correlates of working memory. Read More

J Neurol 2019 Dec 20;266(12):3136-3143. Epub 2019 Sep 20.

IRCCS Istituto delle Scienze Neurologiche di Bologna, 40139, Bologna, Italy.

Prion real-time quaking-induced conversion (RT-QuIC) is emerging as the most potent assay for the in vivo diagnosis of Creutzfeldt-Jakob disease (CJD), but its full application, especially as a screening test, is limited by suboptimal substrate availability, reagent costs, and incomplete assay standardization. Therefore, the search for the most informative cerebrospinal fluid (CSF) surrogate biomarker is still of primary importance. We compared the diagnostic accuracy of CSF protein 14-3-3, measured with both western blot (WB) and enzyme-linked immunosorbent assay (ELISA), total (t)-tau and neurofilament light chain protein (NfL) alone or in combination with RT-QuIC in 212 subjects with rapidly progressive dementia in which we reached a highly probable clinical diagnosis at follow-up or a definite neuropathological diagnosis. Read More

Infect Dis (Auckl) 2019 9;12:1178633719874797. Epub 2019 Sep 9.

Department of Infectious Diseases, Saint Michael's Medical Center, Newark, NJ, USA.

Creutzfeldt-Jakob disease (CJD) is the most common prion disease in humans with an incidence of one case per million inhabitants worldwide. The sporadic form of CJD (sCJD) is spontaneous and accounts for 85% of cases. Its symptoms include rapidly progressive dementia, ataxic gait, personality changes, myoclonus, coma, and eventually death. Read More

Neuropathology 2019 Dec 12;39(6):452-460. Epub 2019 Sep 12.

Department of Neuropathology, Institute for Medical Science of Aging, Aichi Medical University, Nagakute, Japan.

Comprehensive analysis is required for the accurate diagnosis of MV2-type sporadic Creutzfeldt-Jakob disease (sCJD) because it shows a wide clinicopathological spectrum. Here, we describe the clinical findings and neuropathologic observations of an autopsy-confirmed MV2K-type sCJD case with extensive spongiform changes of the cerebral cortex. In the early disease stages, the patient exhibited gait disturbance with ataxia and gradually showed cognitive dysfunction. Read More

Postgrad Med 2019 Sep 16;131(7):501-508. Epub 2019 Sep 16.

1st Department of Neurology, Aiginition Hospital, National and Kapodistrian University of Athens, Medical School , Athens , Greece.

: Aiginition Longitudinal Biomarker Investigation Of Neurodegeneration (ALBION) is a longitudinal ongoing study initiated in 2018 that takes place in the Cognitive Disorders Clinic of Aiginition Hospital of the National and Kapodistrian University of Athens. Its aim is to address several research questions concerning the preclinical and prodromal stage of Alzheimer's disease and explore potential markers for early detection, prediction, and primary prevention of dementia. : We here present the design and the preliminary baseline characteristics of ALBION. Read More

Prog Mol Biol Transl Sci 2019 23;165:25-61. Epub 2019 May 23.

Laboratory of Cognitive and Computational Neuroscience (UCM-UPM), Centre for Biomedical Technology (CTB), Technical University of Madrid (UPM), Madrid, Spain; Department of Experimental Psychology, Complutense University of Madrid (UCM), Madrid, Spain; Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Zaragoza, Spain. Electronic address:

Magnetoencephalography (MEG) is a relatively modern neuroimaging technique able to study normal and pathological brain functioning with temporal resolution in the order of milliseconds and adequate spatial resolution. Although its clinical applications are still relatively limited, great advances have been made in recent years in the field of dementia and Alzheimer's disease (AD) in particular. In this chapter, we briefly describe the physiological phenomena underlying MEG brain signals and the different metrics that can be computed from these data in order to study the alterations disrupting brain activity not only in demented patients, but also in the preclinical and prodromal stages of the disease. Read More

Front Comput Neurosci 2019 13;13:54. Epub 2019 Aug 13.

Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Neurology, Brain Simulation Section, Berlin, Germany.

While the prevalence of neurodegenerative diseases associated with dementia such as Alzheimer's disease (AD) increases, our knowledge on the underlying mechanisms, outcome predictors, or therapeutic targets is limited. In this work, we demonstrate how computational multi-scale brain modeling links phenomena of different scales and therefore identifies potential disease mechanisms leading the way to improved diagnostics and treatment. The Virtual Brain (TVB; thevirtualbrain. Read More

Clin Interv Aging 2019 2;14:1387-1397. Epub 2019 Aug 2.

Department of Neurology, Seoul National University College of Medicine Seoul National University Bundang Hospital, Sungnam, Korea.

A novel prion variant, p.Tyr225Cys (c.674A>G; p. Read More

IEEE Trans Biomed Circuits Syst 2019 10 14;13(5):1101-1111. Epub 2019 Aug 14.

Rodent electroencephalography (EEG) in preclinical research is frequently conducted in behaving animals. However, the difficulty inherent in identifying EEG epochs associated with a particular behavior or cue is a significant obstacle to more efficient analysis. In this paper we highlight a new solution, using infrared event stamping to accurately synchronize EEG, recorded from superficial sites above the hippocampus and prefrontal cortex, with video motion tracking data in a transgenic Alzheimer's disease (AD) mouse model. Read More

Am J Med 2020 01 13;133(1):58-59. Epub 2019 Aug 13.

Department of Medicine, Denver Health Medical Center, University of Colorado School of Medicine, Denver. Electronic address:

Clin Neurophysiol 2019 10 29;130(10):1889-1899. Epub 2019 Jul 29.

Department of Neurology, Danish Dementia Research Centre (DDRC), Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.

Objective: Quantitative EEG power has not been as effective in discriminating between healthy aging and Alzheimer's disease as conventional biomarkers. But EEG coherence has shown promising results in small samples. The overall aim was to evaluate if EEG connectivity markers can discriminate between Alzheimer's disease, mild cognitive impairment, and healthy aging and to explore the early underlying changes in coherence. Read More

Prion 2019 01;13(1):156-159

a Department of Neurology, Universidade Federal de Ciências da Saúde de Porto Alegre, Irmandade Santa Casa de Misericórdia de Porto Alegre , Porto Alegre , Brazil.

We describe a case of probable sporadic Creutzfeldt-Jakob disease in the setting of well-controlled HIV and discuss whether exist, in fact, HIV-related factors that may predispose to the development of prion disease. To the best of our knowledge, this is the third report of this association. Read More

MEDICC Rev 2019 Apr-Jul;21(2-3):54-58

The Panama Aging Research Initiative is a cohort study of 423 adults aged ≥65 years recruited from an outpatient geriatric department of Panama's largest public hospital, the Social Security Fund's Dr Arnulfo Arias Madrid Hospital Complex (Complejo Hospitalario Dr Arnulfo Arias Madrid de la Caja de Seguro Social). The study provides the first reports of modifiable and non-modifiable risk factors of cognitive impairment and dementia, as well as various health conditions common among older adults in Panama, including chronic illnesses, polypharmacy and rates of comorbidity. The initial study, conducted September 2012-May 2016, included a clinical interview; physical assessments of body mass index and handgrip strength; and cognitive testing, plus non-fasting blood draws for measurements of genetic (Apolipoprotein E genotype) and blood-based biological markers. Read More

Acta Neurol Scand 2019 Nov 9;140(5):366-371. Epub 2019 Sep 9.

Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.

Introduction: Previous studies showed concordance between the typical Periodic Sharp Wave Complex (PSWC) activity in EEG of Creutzfeldt-Jakob Disease (CJD) patients and the MRI findings, while the concordance with slow activity in EEG is less established. The aim of this study was to better characterize the association between MRI findings and EEG changes using quantitative EEG (qEEG) analysis.

Methods: The demographics, clinical features, and the MRI findings of 12 familial E200K patients with CJD were gathered. Read More