Search Our Scientific Publications & Authors

Neurobiol Aging 2019 Jan 24;77:112-127. Epub 2019 Jan 24.

Department of Neuroscience Imaging and Clinical Sciences and CESI, University G d'Annunzio of Chieti-Pescara, Chieti, Italy.

Previous evidence has shown different resting-state eyes-closed electroencephalographic delta (<4 Hz) and alpha (8-10.5 Hz) source connectivity in subjects with dementia due to Alzheimer's (ADD) and Lewy body (DLB) diseases. The present study tested if the same differences may be observed in the prodromal stages of mild cognitive impairment (MCI). Read More

J Neurol Neurosurg Psychiatry 2019 Feb 13. Epub 2019 Feb 13.

Academic Unit of Neurology, Trinity College Dublin, the University of Dublin, Dublin, Ireland

Advanced neuroimaging has increased understanding of the pathogenesis and spread of disease, and offered new therapeutic targets. MRI and positron emission tomography have shown that neurodegenerative diseases including Alzheimer's disease (AD), Lewy body dementia (LBD), Parkinson's disease (PD), frontotemporal dementia (FTD), amyotrophic lateral sclerosis (ALS) and multiple sclerosis (MS) are associated with changes in brain networks. However, the underlying neurophysiological pathways driving pathological processes are poorly defined. Read More

J Alzheimers Dis Parkinsonism 2018 30;8(5). Epub 2018 Oct 30.

Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, Nevada, USA.

Background: Developing methods for accurately diagnosing prion diseases has been a challenge in the search for successful diagnosis and treatment of rapidly progressive dementia. prion diseases are rare. However, they should be considered in the differential diagnosis. Read More

Rinsho Shinkeigaku 2019 Feb 31;59(2):93-97. Epub 2019 Jan 31.

Department of Neurology, Nissan Tamagawa Hospital.

We herein report a 67-year-old female who presented with progressive dementia and disturbance of consciousness. Brain CT showed multiple subcortical calcifications with edema. Enhanced CT showed multiple abnormal vessels in the left hemisphere. Read More

PLoS One 2019 24;14(1):e0211184. Epub 2019 Jan 24.

Department of Anesthesiology and Intensive Care Medicine, University Medical Center Rostock, Rostock, Germany.

Sepsis-associated encephalopathy (SAE) contributes to mortality and neurocognitive impairment of sepsis patients. Neurofilament (Nf) light (NfL) and heavy (NfH) chain levels as biomarkers for neuroaxonal injury were not evaluated in cerebrospinal fluid (CSF) and plasma of patients with sepsis-associated encephalopathy (SAE) before. We conducted a prospective, pilot observational study including 20 patients with septic shock and five patients without sepsis serving as controls. Read More

Neuropsychobiology 2019 17;77(4):206-218. Epub 2019 Jan 17.

Department of Psychiatry, Osaka University Graduate School of Medicine, Osaka, Japan.

Background: Dementia with Lewy bodies (DLB) is characterized by progressive cognitive decline, fluctuating cognition, visual hallucinations, rapid eye movement sleep behavior disorder, and parkinsonism. DLB is the second most common type of degenerative dementia of all dementia cases. However, DLB, particularly in the early stage, is underdiagnosed and sometimes misdiagnosed with other types of dementia. Read More

Anaesthesia 2019 Mar 11;74(3):357-372. Epub 2019 Jan 11.

Homerton University Hospital NHS Foundation Trust, London, UK.

Ageing populations have greater incidences of dementia. People with dementia present for emergency and, increasingly, elective surgery, but are poorly served by the lack of available guidance on their peri-operative management, particularly relating to pharmacological, medico-legal, environmental and attitudinal considerations. These guidelines seek to deliver such guidance, by providing information for peri-operative care providers about dementia pathophysiology, specific difficulties anaesthetising patients with dementia, medication interactions, organisational and medico-legal factors, pre-, intra- and postoperative care considerations, training, sources of further information and care quality improvement tools. Read More

Singapore Med J 2018 12;59(12):634-641

Department of Diagnostic Radiology, Division of Radiological Sciences, Singapore General Hospital, Singapore.

A 68-year-old man presented with a three-week history of rapidly progressive dementia, gait ataxia and myoclonus. Subsequent electroencephalography showed periodic sharp wave complexes, and cerebrospinal fluid assay revealed the presence of a 14-3-3 protein. A probable diagnosis of sporadic Creutzfeldt-Jakob disease was made, which was further supported by magnetic resonance (MR) imaging of the brain showing asymmetric signal abnormality in the cerebral cortices and basal ganglia. Read More

eNeuro 2018 Nov-Dec;5(6). Epub 2018 Dec 14.

Department of Neurology and Weill Institute for Neurosciences, University of California, San Francisco, California 94158.

Alzheimer's disease (AD) begins several decades before the onset of clinical symptoms, at a time when women may still undergo reproductive cycling. Whether ovarian functions alter substrates of AD pathogenesis is unknown. Here we show that ovarian cycle stages significantly modulate AD-related alterations in neural network patterns, cognitive impairments, and pathogenic protein production in the hAPP-J20 mouse model of AD. Read More

eNeuro 2018 Nov-Dec;5(6). Epub 2018 Dec 21.

T.J. Watson IBM Research Center, Yorktown Heights, NY 10598.

Abnormal gamma band power across cortex and striatum is an important phenotype of Huntington's disease (HD) in both patients and animal models, but neither the origin nor the functional relevance of this phenotype is well understood. Here, we analyzed local field potential (LFP) activity in freely behaving, symptomatic R6/2 and Q175 mouse models and corresponding wild-type (WT) controls. We focused on periods of quiet rest, which show strong γ activity in HD mice. Read More

Probl Radiac Med Radiobiol 2018 Dec;23:373-409

State Institution «National Research Center for Radiation Medicine of the National Academy of Medical Sciences of Ukraine», Melnykova str., 53, Kyiv, 04050, Ukraine.

Relevance of the present work is determined by the considerable prevalence of both affective and cognitive disor-ders in the victims due to the Chornobyl accident, the pathogenesis of which is insufficiently studied.Objective is to identify the neuropsychiobiological mechanisms of the formation of the remote affective and cog-nitive disorders following exposure to ionizing radiation taking into account the specific gene polymorphisms.Design, object and methods of research. Read More

Brain 2019 Jan;142(1):59-69

Consultant in Neuropathology, Centro Hospitalar São João, Porto, Portugal.

Kufs disease is the major adult form of neuronal ceroid lipofuscinosis, but is rare and difficult to diagnose. Diagnosis was traditionally dependent on the demonstration of characteristic storage material, but distinction from normal age-related accumulation of lipofuscin can be challenging. Mutation of CLN6 has emerged as the most important cause of recessive Kufs disease but, remarkably, is also responsible for variant late infantile ceroid lipofuscinosis. Read More

Neurophysiol Clin 2018 Dec 25;48(6):337-359. Epub 2018 Oct 25.

Department of Radiology and Medical Informatics, University of Geneva, Geneva, Switzerland; Institute of Bioengineering, Center for Neuroprosthetics, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.

Impaired locomotion is a frequent and major source of disability in patients with neurological conditions. Different neuroimaging methods have been used to understand the brain substrates of locomotion in various neurological diseases (mainly in Parkinson's disease) during actual walking, and while resting (using mental imagery of gait, or brain-behavior correlation analyses). These studies, using structural (i. Read More

Elife 2018 11 12;7. Epub 2018 Nov 12.

Neuronal Oscillations Laboratory, Department of Neurobiology, Care Sciences and Society, Center for Alzheimer Research, Neurogeriatrics Division, Karolinska Institutet, Stockholm, Sweden.

Amyloid-β peptide (Aβ) forms plaques in Alzheimer's disease (AD) and is responsible for early cognitive deficits in AD patients. Advancing cognitive decline is accompanied by progressive impairment of cognition-relevant EEG patterns such as gamma oscillations. The endocannabinoid anandamide, a TrpV1-receptor agonist, reverses hippocampal damage and memory impairment in rodents and protects neurons from Aβ-induced cytotoxic effects. Read More

Dis Markers 2018 4;2018:5174815. Epub 2018 Oct 4.

Institut national de la recherche scientifique (INRS-EMT), University of Québec, Montreal, Canada.

Alzheimer's disease (AD) is a neurodegenerative disorder that accounts for nearly 70% of the more than 46 million dementia cases estimated worldwide. Although there is no cure for AD, early diagnosis and an accurate characterization of the disease progression can improve the quality of life of AD patients and their caregivers. Currently, AD diagnosis is carried out using standardized mental status examinations, which are commonly assisted by expensive neuroimaging scans and invasive laboratory tests, thus rendering the diagnosis time consuming and costly. Read More

Biomed Mater Eng 2018 ;29(5):551-566

Department of Computer Engineering and Mathematics, University Rovira i Virgili, Tarragona, 43007, Spain.

Alzheimer is a degenerative disorder that attacks neurons, resulting in loss of memory, thinking, language skills, and behavioral changes. Computer-aided detection methods can uncover crucial information recorded by electroencephalograms. A systematic literature search presents the wavelet transform as a frequently used technique in Alzheimer's detection. Read More

Sheng Li Xue Bao 2018 Oct;70(5):571-578

Department of Physiology, Shanxi Medical University, Taiyuan 030001, China.

APP/PS1/tau triple transgenic (3xTg) mouse is a classical animal model of Alzheimer's disease (AD), which has abnormalities in recognition and electrophysiological properties at early 6-month-old age. However, few studies were performed by using simultaneously recording cognitive behavior and brain electrical activity in the conscious 3xTg mice. By using a new wireless recording system, we recorded hippocampal Theta oscillations in 3xTg mice during the process of fear conditioning test. Read More

Rinsho Shinkeigaku 2018 Nov 27;58(11):682-687. Epub 2018 Oct 27.

Division of CJD Science and Technology, Department of Prion Research, Center for Translational and Advanced Animal Research on Human Diseases, Tohoku University School of Medicine.

A 57-year-old man developed rapidly progressive dementia and a gait disturbance over 4 months. The patient had a slowly progressive executive dysfunction and speech problems for 4 years and was previously monitored in our outpatient clinic following a diagnosis of frontotemporal dementia. Diffusion-weighted MRI revealed high signal intensities in the right caudate nucleus and the bilateral cortices. Read More

Rinsho Shinkeigaku 2018 Nov 27;58(11):673-676. Epub 2018 Oct 27.

Department of Neurology, The Jikei University Kashiwa Hospital.

We report the case of a 43-year-old female patient who presented with symptoms of abnormal behavior, hearing loss, ataxic gait, central hyperventilation which had appeared over the course of one month. Brain MRI showed no abnormal findings in DWI and EEG did not indicate periodic synchronous discharge (PSD). Over the course of the same month, she also presented with central apnea that intermittently showed spontaneous improvement and reappearance. Read More

J Med Syst 2018 Oct 27;42(12):243. Epub 2018 Oct 27.

Faculty of Computer and Information Science, University of Ljubljana, Večna pot 113, Ljubljana, Slovenia.

Machine learning and data mining approaches are being successfully applied to different fields of life sciences for the past 20 years. Medicine is one of the most suitable application domains for these techniques since they help model diagnostic information based on causal and/or statistical data and therefore reveal hidden dependencies between symptoms and illnesses. In this paper we give a detailed overview of the recent machine learning research and its applications for predicting cognitive diseases, especially the Alzheimer's disease, mild cognitive impairment and the Parkinson's disease. Read More

Behav Brain Res 2019 02 24;359:127-134. Epub 2018 Oct 24.

EA 3808, NEUVACOD, University of Poitiers France. Electronic address:

In order to contribute to a better knowledge on the relationship between amyloid and tau pathology, and electroencephalography (EEG) disturbances, the aim of this study was to evaluate the effects of injection of beta amyloid Abeta(1-42) peptide, tau (a recombinant AAV (Adeno-Associated Virus) containing the human transgene tau with the P301 L mutation on rats and the combination of both, on the power of brain's rhythm (delta, theta, alpha, beta and gamma waves) during the different sleep/wake states of animals by EEG recording. Currently, no preclinical studies explore the effect of the tau pathology on EEG. The experimentations were performed 3 weeks and 3 months post injections. Read More

Zh Nevrol Psikhiatr Im S S Korsakova 2018;118(9):94-97

Volgograd State Medical University of Health Ministry of the Russian Federation, Volgograd, Russia.

The familial form of the Creutzfeldt-Jakob disease (ffCJD) refers to a group of rare and severe neurodegenerative diseases associated with pathologic prion protein accumulation. The cause of disease is genetically determined. The disease has a continuously progressive course leading to death in 100% of cases. Read More

Dis Markers 2018 3;2018:6581490. Epub 2018 Sep 3.

Department of Neurology, Christian Doppler Klinik, Paracelsus Medical University, Salzburg, Austria.

The clinical distinction of frontotemporal dementia (FTD) and Alzheimer's disease (AD) may be difficult. In this narrative review we summarize and discuss the most relevant electroencephalography (EEG) studies which have been applied to demented patients with the aim of distinguishing the various types of cognitive impairment. EEG studies revealed that patients at an early stage of FTD or AD displayed different patterns in the cortical localization of oscillatory activity across different frequency bands and in functional connectivity. Read More

Neuropharmacology 2018 12 19;143:130-142. Epub 2018 Sep 19.

Department of Translational Biology, H. Lundbeck A/S, Valby, Denmark. Electronic address:

Cognitive impairments in Alzheimer's disease (AD) have been associated with alterations in neuronal oscillatory activity, of which hippocampal theta and gamma oscillations are essential for the coordination of neuronal networks during cognitive functions. Cognitive deterioration in AD is delayed by symptomatic treatment with donepezil and other acetylcholinesterase inhibitors (AChEIs). However, the efficacy of symptomatic monotherapy is insufficient. Read More

Comput Methods Programs Biomed 2018 Oct 27;164:1-13. Epub 2018 Jun 27.

Department of Psychology, Concordia University, Montreal, Quebec, Canada.

Background And Objective: In this study we investigate whether or not event-related potentials (ERP) and/or event-related (de)synchronization (ERD/ERS) can be used to differentiate between 27 healthy elderly (HE), 21 subjects diagnosed with mild cognitive impairment (MCI) and 15 mild Alzheimer's disease (AD) patients.

Methods: Using 32-channel EEG recordings, we measured ERP responses to a three-level (N-back, N = 0,1,2) visual working memory task. We also performed ERD analysis over the same EEG data, dividing the full-band signal into the well-known delta, theta, alpha, beta and gamma bands. Read More

Ann Biomed Eng 2019 Jan 30;47(1):282-296. Epub 2018 Aug 30.

Starlab Barcelona, Barcelona, Spain.

Idiopathic rapid eye movement sleep behavior disorder (RBD) is a serious risk factor for neurodegenerative processes such as Parkinson's disease (PD). We investigate the use of EEG algorithmic complexity derived metrics for its prognosis. We analyzed resting state EEG data collected from 114 idiopathic RBD patients and 83 healthy controls in a longitudinal study forming a cohort in which several RBD patients developed PD or dementia with Lewy bodies. Read More

Int J Environ Res Public Health 2018 08 15;15(8). Epub 2018 Aug 15.

Convergence Research Center for Diagnosis, Treatment and Care System of Dementia, Korea Institute of Science and Technology (KIST), 02792 Seoul, Korea.

Interest in research involving health-medical information analysis based on artificial intelligence, especially for deep learning techniques, has recently been increasing. Most of the research in this field has been focused on searching for new knowledge for predicting and diagnosing disease by revealing the relation between disease and various information features of data. These features are extracted by analyzing various clinical pathology data, such as EHR (electronic health records), and academic literature using the techniques of data analysis, natural language processing, etc. Read More

Can J Neurol Sci 2018 07;45(4):462-463

1Department of Clinical Neurological Sciences,Western University,London,Ontario,Canada.

Epilepsy Behav 2018 09 19;86:157-162. Epub 2018 Jul 19.

"La Sapienza" University, Department of Pediatrics, Child Neurology Division, Italy. Electronic address:

Introduction: Rolandic epilepsy, also known as benign childhood epilepsy with centrotemporal spikes (BECTS), is one of the most common epileptic syndromes in previously healthy children. Despite what was known about the benignity of this syndrome, there is always more evidence about the involvement of the cognitive functions with different deficits in several domains to be investigated.

Aim Of The Study: The aim of our study was to describe prognostic electroencephalogram (EEG) pattern of an adverse cognitive development to recognize patients at higher risk of lasting cognitive deficits that could need antiepileptic drugs (AEDs) or an improved neurocognitive therapy. Read More

Exp Mol Pathol 2018 08 23;105(1):98-109. Epub 2018 Jun 23.

Department of Molecular Biophysics, Faculty of Biology and Environmental Protection, University of Lodz, Pomorska Street No 141/143, 90-236 Lodz, Poland; The Military Medical Training Center, 6 Sierpnia Street No 92, 90-646 Lodz, Poland.

Since the first identification of fullerenes (C) and their synthesis in 1985, those compounds have been extensively studied in the biomedical field. In particular, their water-soluble derivatives, fullerenols (C(OH) n = 2-48), have recently been the subject of numerous investigations concerning their antioxidant and prooxidant properties in biological systems. A small fraction of that research has focused on the possible use of C and C(OH) in neuroscience and the therapy of pathologies such as dementia, amyloid-β (Aβ) formation, and Parkinson's disease. Read More

Methods Mol Biol 2018 ;1780:221-239

Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK.

The limitations of using small-brained rodents to model diseases that affect large-brain humans are becoming increasingly obvious as novel therapies emerge. Huntington's disease (HD) is one such disease. In recent years, the desirability of a large-brained, long-lived animal model of HD for preclinical testing has changed into a necessity. Read More

BMC Med Inform Decis Mak 2018 05 31;18(1):35. Epub 2018 May 31.

IRCCS Centro Neurolesi "Bonino-Pulejo", Contrada Casazza, SS113, Messina, 98124, Italy.

Background: Alzheimer's Disease (AD) is a neurodegenaritive disorder characterized by a progressive dementia, for which actually no cure is known. An early detection of patients affected by AD can be obtained by analyzing their electroencephalography (EEG) signals, which show a reduction of the complexity, a perturbation of the synchrony, and a slowing down of the rhythms.

Methods: In this work, we apply a procedure that exploits feature extraction and classification techniques to EEG signals, whose aim is to distinguish patient affected by AD from the ones affected by Mild Cognitive Impairment (MCI) and healthy control (HC) samples. Read More

Clin Neuropharmacol 2018 Jul/Aug;41(4):142-144

Hospital Israelita Albert Einstein, São Paulo, Brazil.

Myoclonic status epilepticus (MSE) in patients without epilepsy, or de novo MSE, is a rare condition associated with several acute symptomatic etiologies, including drugs and toxins. We describe a 94-year-old woman with Alzheimer dementia and long use of mirtazapine 30 mg/d and alprazolam 1 mg/d who developed MSE approximately 24 hours after abrupt discontinuation of alprazolam. The patient was taking sulfamethoxazole/trimethoprim for urinary tract infection, diagnosed 2 weeks before admission. Read More

PLoS Comput Biol 2018 05 24;14(5):e1006136. Epub 2018 May 24.

Biomedical Engineering Graduate Program, University of Calgary, Calgary, Alberta, Canada.

Brain stimulation can modulate the activity of neural circuits impaired by Alzheimer's disease (AD), having promising clinical benefit. However, all individuals with the same condition currently receive identical brain stimulation, with limited theoretical basis for this generic approach. In this study, we introduce a control theory framework for obtaining exogenous signals that revert pathological electroencephalographic activity in AD at a minimal energetic cost, while reflecting patients' biological variability. Read More

eNeuro 2018 Mar-Apr;5(2). Epub 2018 May 17.

Centre for Discovery Brain Sciences, University of Edinburgh, Edinburgh, EH8 9JZ, United Kingdom.

Network hyperexcitability is a feature of Alzheimer' disease (AD) as well as numerous transgenic mouse models of AD. While hyperexcitability in AD patients and AD animal models share certain features, the mechanistic overlap remains to be established. We aimed to identify features of network hyperexcitability in AD models that can be related to epileptiform activity signatures in AD patients. Read More

Brain Behav 2018 05 15;8(5):e00966. Epub 2018 Apr 15.

Department of Neurosurgery The Third Affiliated Hospital of Soochow University Changzhou Jiangsu China.

Objective: This study's aim was to investigate the features and neural mechanisms of sustained attention in patients with mild traumatic brain injury (mTBI) by comparing and analyzing neuropsychological, behavioral, event-related potentials, and event-related desynchronization and synchronization between mTBI patients and healthy controls.

Methods: Twenty mTBI patients with mTBI and 20 healthy controls underwent the Mini-Mental State Examination (MMSE) and a cued continuous performance task (AX-CPT). Neuropsychological, behavioral, and electroencephalogram (EEG) data were collected and analyzed. Read More

Int J Comput Assist Radiol Surg 2018 Jun 7;13(6):935-946. Epub 2018 May 7.

Wellcome/EPSRC Centre for Interventional and Surgical Sciences, UCL, London, UK.

Purpose: The accurate and automatic localisation of SEEG electrodes is crucial for determining the location of epileptic seizure onset. We propose an algorithm for the automatic segmentation of electrode bolts and contacts that accounts for electrode bending in relation to regional brain anatomy.

Methods: Co-registered post-implantation CT, pre-implantation MRI, and brain parcellation images are used to create regions of interest to automatically segment bolts and contacts. Read More

J Med Case Rep 2018 May 8;12(1):128. Epub 2018 May 8.

Chelsea and Westminster Hospitals NHS Foundation Trust, West Middlesex University Hospital, Twickenham Rd, Isleworth, TW7 6AF, UK.

Background: Creutzfeldt-Jakob disease is a rare and rapidly fatal neurodegenerative disease. Since clinicians may see only very few cases during their professional career, it is important to be familiar with the clinical presentation and progression, to perform appropriate investigations, and allow for quick diagnosis.

Case Presentation: A 73-year-old British Caucasian woman presented with acute confusion of 2 weeks' duration on a background of low mood following a recent bereavement. Read More

J Neurol 2018 Jul 3;265(7):1573-1579. Epub 2018 May 3.

Department of Neurology, Centre for Movement Disorders and Neuromodulation, Medical Faculty, Heinrich-Heine-University Düsseldorf, Moorenstrasse 5, 40225, Düsseldorf, Germany.

Background: Recently, therapeutic attempts to control motor choreatic hyperkinesia of Huntington's disease (HD) by means of pallidal deep brain stimulation (Gp-DBS) were successful. With respect to the clinical effects of Gp-DBS in juvenile hypokinetic-rigid HD (jHD; Westphal variant), only one single-case has been reported up to date. Oscillatory patterns of the Gp in jHD are not known. Read More

Clin Neurophysiol 2018 Aug 17;129(8):1720-1747. Epub 2018 Apr 17.

Institute for Learning & Brain Sciences, University of Washington, Seattle, WA, USA; Department of Physics, University of Washington, Seattle, WA, USA.

Magnetoencephalography (MEG) records weak magnetic fields outside the human head and thereby provides millisecond-accurate information about neuronal currents supporting human brain function. MEG and electroencephalography (EEG) are closely related complementary methods and should be interpreted together whenever possible. This manuscript covers the basic physical and physiological principles of MEG and discusses the main aspects of state-of-the-art MEG data analysis. Read More

Case Rep Crit Care 2018 14;2018:5053175. Epub 2018 Feb 14.

University of Nevada School of Medicine, Reno, NV, USA.

Creutzfeldt-Jakob disease (CJD), the most common form of human prion diseases, is a fatal condition with a mortality rate reaching 85% within one year of clinical presentation. CJD is characterized by rapidly progressive neurological deterioration in combination with typical electroencephalography (EEG) and magnetic resonance imaging (MRI) findings and positive cerebrospinal spinal fluid (CSF) analysis for 14-3-3 proteins. Unfortunately, CJD can have atypical clinical and radiological presentation in approximately 10% of cases, thus making the diagnosis often challenging. Read More

Neurobiol Aging 2018 07 19;67:75-83. Epub 2018 Mar 19.

Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands; Department of Neuroscience and Psychiatry, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands; Department of Biological and Medical Psychology, Faculty of Psychology, University of Bergen, Bergen, Norway.

We studied neurophysiological indicators of hallucinations in Alzheimer's disease patients with hallucinations (ADhall+), and compared them with nonhallucinating AD (ADhall-) and dementia with Lewy bodies (DLBhall+) patients. Thirty-six matched ADhall+ and 108 ADhall- and 29 DLBhall+ patients were selected from the Amsterdam Dementia Cohort. Electroencephalography (EEG) spectral and functional connectivity (FC) analyses (phase lag index) were performed. Read More

Medicine (Baltimore) 2018 Apr;97(15):e0299

Department of Neurology and Neuroscience Center, The First Hospital of JiLin University, Changchun.

Introduction: Progressive myoclonic epilepsy (PME) is rare epilepsy syndrome. Although EEG is a useful neurophysiological technique in the evaluation of epilepsy, few EEG abnormalities have been described in PME. So, how to use EEG hints to establish the suspected diagnosis of PME as soon as possible should be addressed. Read More

J Biol Chem 2018 06 9;293(22):8462-8472. Epub 2018 Apr 9.

the Department of Psychiatry, Douglas Mental Health University Institute, McGill University, Quebec H4H 1R3, Canada.

Tau hyperphosphorylation at several sites, including those close to the microtubule domain region (MDr), is considered a key pathological event in the development of Alzheimer's disease (AD). Recent studies indicate that at the very early stage of this disease, increased phosphorylation in Tau's MDr domain correlates with reduced levels of neuronal excitability. Mechanistically, we show that pyramidal neurons and some parvalbumin-positive interneurons in 1-month-old triple-transgenic AD mice accumulate hyperphosphorylated Tau protein and that this accumulation correlates with changes in theta oscillations in hippocampal neurons. Read More

Presse Med 2018 Mar 24;47(3):261-265. Epub 2018 Mar 24.

CHU de Pellegrin-Tripode, département des neurosciences cliniques, Bordeaux, France. Electronic address:

Epilepsy increases in frequency with age, above 60, with consequences in terms of independence. Stroke and dementia are the most frequent etiologies. Clinical diagnostic of epileptic seizure is challenging at this age, and a clinical algorithm is proposed. Read More

Multivariate Behav Res 2018 May-Jun;53(3):348-359. Epub 2018 Mar 22.

d Department of Neurology, Christian Doppler Medical Centre and Centre for Cognitive Neuroscience , Paracelsus Medical University.

To date, there is a lack of satisfactory inferential techniques for the analysis of multivariate data in factorial designs, when only minimal assumptions on the data can be made. Presently available methods are limited to very particular study designs or assume either multivariate normality or equal covariance matrices across groups, or they do not allow for an assessment of the interaction effects across within-subjects and between-subjects variables. We propose and methodologically validate a parametric bootstrap approach that does not suffer from any of the above limitations, and thus provides a rather general and comprehensive methodological route to inference for multivariate and repeated measures data. Read More

Medicine (Baltimore) 2018 Mar;97(12):e0162

Karolinska University Hospital Huddinge, Department of Infectious Diseases.

Rationale: Cognitive dysfunction is a common presenting symptom in patients with HIV/AIDS. It is usually directly associated with HIV infection or due to opportunistic infection. Rapidly progressive dementia, however, is rarely observed in acute HIV infection or during immune reconstitution. Read More

PLoS One 2018 20;13(3):e0193607. Epub 2018 Mar 20.

AP-HP, DHU FAST, GH Pitié-Salpêtrière-Charles Foix, Functional Exploration Unit of older patients, Ivry-sur-Seine, France.

This study addresses the problem of Alzheimer's disease (AD) diagnosis with Electroencephalography (EEG). The use of EEG as a tool for AD diagnosis has been widely studied by comparing EEG signals of AD patients only to those of healthy subjects. By contrast, we perform automated EEG diagnosis in a differential diagnosis context using a new database, acquired in clinical conditions, which contains EEG data of 169 patients: subjective cognitive impairment (SCI) patients, mild cognitive impairment (MCI) patients, possible Alzheimer's disease (AD) patients, and patients with other pathologies. Read More

BMJ Open 2018 03 17;8(3):e017079. Epub 2018 Mar 17.

Department of Anesthesiology, Washington University School of Medicine in St. Louis, Saint Louis, Missouri, USA.

Introduction: Postoperative delirium (POD) is a common complication in elderly patients, characterised by a fluctuating course of altered consciousness, disordered thinking and inattention. Preliminary research has linked POD with persistent cognitive impairment and decreased quality of life. However, these findings maybe confounded by patient comorbidities, postoperative complications and frailty. Read More

J Ethnopharmacol 2018 Aug 13;222:229-238. Epub 2018 Mar 13.

Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100193, China. Electronic address:

Ethnopharmacological Relevance: Vascular dementia (VaD) is the common cognitive disorder derived mainly from lacunar stroke (LS). The oxidative stress induced neurovascular coupling (NVC) dysfunction involves in the pathogenesis of VaD. Currently, there is no specific drug for VaD. Read More