999 results match your criteria EEG in Common Epilepsy Syndromes


Co-existence of Rolandic and 3 Hz Spike-Wave Discharges on EEG in Children with Epilepsy.

Can J Neurol Sci 2018 Dec 3:1-7. Epub 2018 Dec 3.

1Department of Pediatrics, Division of Neurology,BC Children's Hospital,Vancouver, British Columbia,Canada.

Objective: Benign epilepsy of childhood with central temporal spikes (BECTS) and absence epilepsy are common epilepsy syndromes in children with similar age of onset and favorable prognosis. However, the co-existence of the electrocardiogram (EEG) findings of rolandic spike and 3 Hz generalized spike-wave (GSW) discharges is extremely rare, with few cases reported in the literature. Our objective was to characterize the EEG findings of these syndromes in children in our center and review the electro-clinical features. Read More

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http://dx.doi.org/10.1017/cjn.2018.364DOI Listing
December 2018
1 Read

The prevalence of neural antibodies in temporal lobe epilepsy and the clinical characteristics of seropositive patients.

Seizure 2018 Dec 17;63:1-6. Epub 2018 Sep 17.

Department of Neurology, Second Faculty of Medicine, Charles University, Motol University Hospital, Czech Republic.

Purpose: Epileptic seizures are a common manifestation of autoimmune encephalitis, but the role of neural antibodies in long-term epilepsy remains unclear. The aim of this study was to assess the prevalence of neural-surface antibodies (NSAbs) and antibodies against glutamic acid decarboxylase (GAD) in patients with chronic temporal lobe epilepsy (TLE).

Method: Patients with an electro-clinical diagnosis of TLE and a disease duration longer than one year were included. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10591311183005
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http://dx.doi.org/10.1016/j.seizure.2018.09.009DOI Listing
December 2018
7 Reads

Does pain sensitivity increase during ictal period? Evidence from absence epileptic WAG/Rij rats.

Epilepsy Behav 2018 Aug 25;87:14-17. Epub 2018 Aug 25.

Karadeniz Technical University, Faculty of Medicine, Department of Physiology, Trabzon, Turkey.

Objective: The hyperexcitable brain provides a common ground for comorbidity of pain syndromes and epilepsy. There are controversial reports about pain sensitivity during the ictal period. We analyzed the pain sensitivity during the ictal period in the genetic absence epilepsy animal model, Wistar Albino Glaxo/Rijswijk (WAG/Rij) rats. Read More

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http://dx.doi.org/10.1016/j.yebeh.2018.08.001DOI Listing
August 2018
2 Reads

Could Rolandic spikes be a prognostic factor of the neurocognitive outcome of children with BECTS?

Epilepsy Behav 2018 Sep 19;86:157-162. Epub 2018 Jul 19.

"La Sapienza" University, Department of Pediatrics, Child Neurology Division, Italy. Electronic address:

Introduction: Rolandic epilepsy, also known as benign childhood epilepsy with centrotemporal spikes (BECTS), is one of the most common epileptic syndromes in previously healthy children. Despite what was known about the benignity of this syndrome, there is always more evidence about the involvement of the cognitive functions with different deficits in several domains to be investigated.

Aim Of The Study: The aim of our study was to describe prognostic electroencephalogram (EEG) pattern of an adverse cognitive development to recognize patients at higher risk of lasting cognitive deficits that could need antiepileptic drugs (AEDs) or an improved neurocognitive therapy. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15255050183010
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http://dx.doi.org/10.1016/j.yebeh.2018.03.022DOI Listing
September 2018
4 Reads

Quantitative and qualitative analysis of ictal vocalization in focal epilepsy syndromes.

Seizure 2018 Aug 11;60:178-183. Epub 2018 Jul 11.

Epilepsy Center, Department of Neurology, University Hospital, LMU Munich, Munich, Germany.

Purpose: To investigate the frequency, localizing significance, and intensity characteristics of ictal vocalization in different focal epilepsy syndromes.

Methods: Up to four consecutive focal seizures were evaluated in 277 patients with lesional focal epilepsy, excluding isolated auras and subclinical EEG seizure patterns. Vocalization was considered to be present if observed in at least one of the analyzed seizures and not being of speech quality. Read More

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http://dx.doi.org/10.1016/j.seizure.2018.07.008DOI Listing
August 2018
11 Reads

Genetic etiologies of the electrical status epilepticus during slow wave sleep: systematic review.

BMC Genet 2018 Jul 6;19(1):40. Epub 2018 Jul 6.

Department of Pediatrics, Xiangya Hospital, Central South University, 87 Xiang Ya Road, Changsha, 410008, Hunan Province, China.

Background: Electrical status epilepticus during slow-wave sleep (ESESS) which is also known as continuous spike-wave of slow sleep (CSWSS) is type of electroencephalographic (EEG) pattern which is seen in ESESS/CSWSS/epilepsy aphasia spectrum. This EEG pattern can occur alone or with other syndromes. Its etiology is not clear, however, brain malformations, immune disorders, and genetic etiologies are suspected to contribute. Read More

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http://dx.doi.org/10.1186/s12863-018-0628-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6034250PMC
July 2018
27 Reads

Asynchronous suppression of visual cortex during absence seizures in stargazer mice.

Nat Commun 2018 05 16;9(1):1938. Epub 2018 May 16.

Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

Absence epilepsy is a common childhood disorder featuring frequent cortical spike-wave seizures with a loss of awareness and behavior. Using the calcium indicator GCaMP6 with in vivo 2-photon cellular microscopy and simultaneous electrocorticography, we examined the collective activity profiles of individual neurons and surrounding neuropil across all layers in V1 during spike-wave seizure activity over prolonged periods in stargazer mice. We show that most (~80%) neurons in all cortical layers reduce their activity during seizures, whereas a smaller pool activates or remains neutral. Read More

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http://dx.doi.org/10.1038/s41467-018-04349-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5955878PMC
May 2018
2 Reads

De novo late-onset absence status epilepticus or late-onset idiopathic generalized epilepsy? A case report and systematic review of the literature.

Epileptic Disord 2018 Apr;20(2):123-131

Department of Neurology, Christian Doppler Medical Centre, Paracelsus Medical University, Salzburg, Center for Cognitive Neuroscience, Salzburg, University for Health Sciences, Medical Informatics and Technology, Hall IT, Austria.

Idiopathic (genetic) generalized epilepsies (IGEs) are age-related epileptic syndromes with typical age onset in childhood or adolescence. We report a patient with de novo late-onset absence status epilepticus (ASE) occurring at the age of 64 years, with clinical and EEG features suggestive of late-onset IGE. We also discuss the relationship between de novo late-onset ASE and late-onset IGE, and provide a comprehensive and critical review of the available literature on late-onset (i. Read More

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http://dx.doi.org/10.1684/epd.2018.0961DOI Listing
April 2018
4 Reads

Panayiotopoulos syndrome and benign partial epilepsy with centro-temporal spikes: A comparative incidence study.

Seizure 2018 Apr 5;57:66-69. Epub 2018 Mar 5.

Alder Hey Children's Hospital, Liverpool, United Kingdom.

Purpose: To compare the de novo incidence of Panayiotopoulos syndrome (PS, early-onset childhood occipital epilepsy) and a common epilepsy syndrome, benign epilepsy with centro-temporal spikes (BECTS), in children and young people.

Methods: The incidence of PS and BECTS was recorded over 16 months in a population of children and young people (aged <16 years) living within a specific geographic area and epilepsy network within the North West of England and North Wales and the catchment area of the tertiary paediatric epilepsy centre. Monthly data collection proformas were circulated to the paediatricians and paediatric neurologists responsible for the evaluation of epilepsy in children within this area. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10591311173079
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http://dx.doi.org/10.1016/j.seizure.2018.03.002DOI Listing
April 2018
5 Reads

The Pilocarpine Model of Temporal Lobe Epilepsy and EEG Monitoring Using Radiotelemetry System in Mice.

J Vis Exp 2018 02 27(132). Epub 2018 Feb 27.

Department of Pharmacology, Catholic Neuroscience Institute, College of Medicine, The Catholic University of Korea;

Temporal lobe epilepsy (TLE) is a common neurological disorder in adulthood. For translational studies of chronic epilepsy, pilocarpine-induced status epilepticus (SE) is frequently selected to recapitulate spontaneous recurrent seizures (SRS). Here we present a protocol of SE induction by intraperitoneal (i. Read More

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http://dx.doi.org/10.3791/56831DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5931368PMC
February 2018
5 Reads

Electroclinical and prognostic characteristics of epilepsy patients with photosensitivity.

Ideggyogy Sz 2018 Jan;71(1-02):43-48

İstanbul University Institute of Forensic Medicine, Istanbul, Turkey.

Background And Purpose: Epilepsy with photosensitivity (PSE) is one of the reflex epilepsy types with pathophysiology still unexplained. In our study we aimed to evaluate the clinical, electroencephalogram (EEG) and prognosis of patients with PSE diagnosis.

Methods: A total of 44 patients with PSE diagnosis according to international classification were included in this retrospective and cross-sectional study. Read More

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http://dx.doi.org/10.18071/isz.71.0043DOI Listing
January 2018
4 Reads

Insulo-opercular cortex generates oroalimentary automatisms in temporal seizures.

Epilepsia 2018 03 2;59(3):583-594. Epub 2018 Feb 2.

Epilepsy Center, Cleveland Clinic Neurological Institute, Cleveland, OH, USA.

Objective: Oroalimentary automatisms (OAAs) resembling normal alimentary behavior are stereotyped complex movements that may occur during epileptic seizures. They are considered common clinical signs in temporal lobe seizures, but their anatomofunctional mechanisms are not established. We took the opportunity of presurgical intracerebral recordings to study the relations between the occurrence of OAAs and temporal/spatial features of ictal activities. Read More

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http://dx.doi.org/10.1111/epi.14011DOI Listing

The interictal mesial temporal lobe epilepsy network.

Epilepsia 2018 01 5;59(1):244-258. Epub 2017 Dec 5.

Department of Neurosurgery, University of Texas Health Science Center at Houston, Houston, TX, USA.

Objective: Identification of patient-specific epileptogenic networks is critical to designing successful treatment strategies. Multiple noninvasive methods have been used to characterize epileptogenic networks. However, these methods lack the spatiotemporal resolution to allow precise localization of epileptiform activity. Read More

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http://dx.doi.org/10.1111/epi.13959DOI Listing
January 2018
2 Reads

Efficacy and safety of vigabatrin in Japanese patients with infantile spasms: Primary short-term study and extension study.

Authors:
Yoko Ohtsuka

Epilepsy Behav 2018 01 22;78:134-141. Epub 2017 Dec 22.

Department of Child Neurology, Asahigawaso Rehabilitation and Medical Center, 866 Gion, Kita-ku, Okayama, Japan. Electronic address:

Vigabatrin was approved for the treatment of infantile spasms by the US Food and Drug Administration, but not in Japan at the time of initiating this clinical study because of concerns about irreversible peripheral visual field defects (VFDs). This study evaluated the efficacy and safety of vigabatrin for Japanese patients with infantile spasms. Of 15 patients (aged ≥4weeks and <2years) enrolled, with the exception of two patients who did not receive vigabatrin, 13 were treated with a titrated dosage of vigabatrin (50-150mg/kg/day; limited to 3000mg/day). Read More

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http://dx.doi.org/10.1016/j.yebeh.2017.09.010DOI Listing
January 2018
2 Reads

Recognition of Infantile Spasms Is Often Delayed: The ASSIST Study.

J Pediatr 2017 11;190:215-221.e1

Department of Neurology, David Geffen School of Medicine and Mattel Children's Hospital UCLA, Los Angeles, CA; Department of Neurology, University of Colorado School of Medicine, Aurora, CO.

Objectives: To characterize and quantify diagnostic and treatment delay among children with infantile spasms, and to estimate the developmental impact of this delay.

Study Design: In this cohort study, we surveyed the parents of 100 patients with infantile spasms about their experiences with diagnosis and treatment, and ascertained medical and sociodemographic factors potentially related to care of these infants. We specifically determined the latency to first visit an "effective provider," defined as a provider who identified infantile spasms, and prescribed an appropriate first-line treatment, namely adrenocorticotropic hormone, corticosteroids, or vigabatrin. Read More

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http://dx.doi.org/10.1016/j.jpeds.2017.08.009DOI Listing
November 2017
3 Reads

Benign Rolandic epilepsy presenting like paradoxical vocal fold motion.

Int J Pediatr Otorhinolaryngol 2017 Nov 22;102:154-156. Epub 2017 Sep 22.

Washington University School of Medicine, Department of Otolaryngology, 660 South Euclid Avenue, Saint Louis, Missouri 63110, USA. Electronic address:

Paradoxical vocal fold motion (PVFM) is characterized by vocal fold adduction during respiration. Benign Rolandic epilepsy (BRE) is the most common childhood epilepsy and can cause oropharyngolaryngeal or facial manifestations. A 9-year-old male presented with intermittent apnea lasting 30-60 seconds and presumed PVFM. Read More

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http://dx.doi.org/10.1016/j.ijporl.2017.09.021DOI Listing
November 2017
12 Reads

Cognitive and behavioral comorbidities in Rolandic epilepsy and their relation with default mode network's functional connectivity and organization.

Epilepsy Behav 2018 01 2;78:179-186. Epub 2017 Nov 2.

Faculty of Medicine, University of Freiburg, Germany; Clinic for Radiology, Medical Physics, Medical Center - University of Freiburg, Germany.

Objective: Rolandic epilepsy (RE) is characterized by typical interictal-electroencephalogram (EEG) patterns mainly localized in centrotemporal and parietooccipital areas. An aberrant intrinsic organization of the default mode network (DMN) due to repeated disturbances from spike-generating areas may be able to account for specific cognitive deficits and behavioral problems in RE. The aim of the present study was to investigate cognitive development (CD) and socioemotional development (SED) in patients with RE during active disease in relation to DMN connectivity and network topology. Read More

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http://dx.doi.org/10.1016/j.yebeh.2017.10.013DOI Listing
January 2018
9 Reads

Sub-cortical brain morphometry and its relationship with cognition in rolandic epilepsy.

Epilepsy Res 2017 12 7;138:39-45. Epub 2017 Oct 7.

CHU Sainte-Justine, Montreal, Quebec, Canada; University of Montreal, Department of Psychology, Montreal, Quebec, Canada.

Purpose: Rolandic epilepsy (RE), also called benign epilepsy with centrotemporal spikes (BECTS) is the most common childhood epilepsy syndrome. RE is associated with cognitive difficulties, which can affect children's quality of life. The underlying causes of these cognitive impairments are unclear. Read More

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http://dx.doi.org/10.1016/j.eplepsyres.2017.09.007DOI Listing
December 2017
11 Reads

A quinidine non responsive novel KCNT1 mutation in an Indian infant with epilepsy of infancy with migrating focal seizures.

Brain Dev 2018 Mar 14;40(3):229-232. Epub 2017 Oct 14.

Child Neurology Division, Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, India. Electronic address:

Epilepsy of infancy with migrating focal seizures {a.k.a malignant migrating partial seizures of infancy (MMPSI)} is an uncommon epileptic encephalopathy with a poor prognosis. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03877604173026
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http://dx.doi.org/10.1016/j.braindev.2017.09.008DOI Listing
March 2018
9 Reads

"Atypical forms" of benign epilepsy with centrotemporal spikes (BECTS): How to diagnose and guide these children. A practical/scientific approach.

Epilepsy Behav 2017 10 1;75:165-169. Epub 2017 Sep 1.

Child Neurology, Headache Paediatric Center, Paediatric Sleep Disorders, NESMOS Department, Chair of Pediatrics, Faculty of Medicine and Psychology, Sapienza University, c/o Sant'Andrea Hospital, Rome, Italy.

Benign epilepsy with centrotemporal spikes (BECTS) epilepsy, also known as rolandic epilepsy, is the most common childhood type of epilepsy. There is debate on its "benign" definition given the numerous literature data on its correlation to cognitive morbidity. Although its prognosis is often favorable, BECTS can present or evolve however to an atypical form, characterized by a worse prognosis and negative impact on cognitive development. Read More

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http://dx.doi.org/10.1016/j.yebeh.2017.08.001DOI Listing
October 2017
13 Reads

Establishment of a rhesus monkey model of chronic temporal lobe epilepsy using repetitive unilateral intra-amygdala kainic acid injections.

Brain Res Bull 2017 Sep 7;134:273-282. Epub 2017 Sep 7.

The National Key Clinic Specialty, The Engineering Technology Research Center of Education Ministry of China, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, Department of Neurosurgery, Zhujiang Hospital, Southern Medical University, Guangzhou, 510282, China. Electronic address:

Objective: Temporal lobe epilepsy (TLE) is a common type of acquired epilepsy refractory to medical treatment. As such, establishing animal models of this disease is critical to developing new and effective treatment modalities. Because of their small head size, rodents are not suitable for comprehensive electroencephalography (EEG) evaluation via scalp or subdural electrodes. Read More

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http://dx.doi.org/10.1016/j.brainresbull.2017.08.010DOI Listing
September 2017
10 Reads

Atonic seizures in children with surgically remediable epilepsy: a motor system seizure phenotype?

Epileptic Disord 2017 Sep;19(3):315-326

Medical and Surgical Epilepsy Unit, Hautepierre Hospital, University of Strasbourg, Strasbourg, IDEE Epilepsy Institute, Lyon, France.

Atonic seizures are common in some epileptic syndromes beginning in infancy or early childhood but they are rarely described in epilepsy with focal seizures of structural aetiology. We aimed to characterize the electroclinical features of atonic seizures in surgically remediable paediatric patients and to study the spatiotemporal organization of the underlying epileptogenic networks. We retrospectively analysed two consecutive, longitudinally evaluated and surgically treated paediatric patients presenting with atonic seizures as a manifestation of pharmacoresistant epilepsy of structural aetiology, evidenced by scalp- and stereotactic intracerebral video-EEG-recordings. Read More

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http://dx.doi.org/10.1684/epd.2017.0930DOI Listing
September 2017
8 Reads

Epilepsy in fragile-X-syndrome mimicking panayiotopoulos syndrome: Description of three patients.

Am J Med Genet A 2017 Oct 16;173(10):2753-2757. Epub 2017 Aug 16.

Scientific Institute, IRCCS Eugenio Medea, Conegliano, Treviso, Italy, Epilepsy and Neurophysiology Unit.

Fragile-X-syndrome is the most common cause of inherited intellectual disability. Epilepsy is reported to occur in 10-20% of individuals with Fragile-X-syndrome. A frequent seizure/electroencephalogram (EEG) pattern resembles that of benign rolandic epilepsy. Read More

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http://dx.doi.org/10.1002/ajmg.a.38373DOI Listing
October 2017
28 Reads

Subclinical Rhythmic EEG Discharge of Adult (SREDA) in a Child With Generalized Epilepsy and Literature Review of SREDA in Children.

J Clin Neurophysiol 2018 May;35(3):270-272

Division of Neurology, Children's Mercy Hospital, Kansas City, Missouri, U.S.A.

Subclinical rhythmic discharges of adult (SREDA) is a rare benign EEG variant in adults and is of unknown clinical significance. Its occurrence in children is extremely rare. In review of the literature, it has been described in only four children. Read More

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http://dx.doi.org/10.1097/WNP.0000000000000408DOI Listing
May 2018
16 Reads

Rationale for an adjunctive therapy with fenofibrate in pharmacoresistant nocturnal frontal lobe epilepsy.

Epilepsia 2017 10 2;58(10):1762-1770. Epub 2017 Aug 2.

Neuroscience Institute, National Research Council of Italy, Cagliari, Italy.

Objective: Nocturnal frontal lobe epilepsy (NFLE) is an idiopathic partial epilepsy with a family history in about 25% of cases, with autosomal dominant inheritance (autosomal dominant NFLE [ADNFLE]). Traditional antiepileptic drugs are effective in about 55% of patients, whereas the rest remains refractory. One of the key pathogenetic mechanisms is a gain of function of neuronal nicotinic acetylcholine receptors (nAChRs) containing the mutated α4 or β2 subunits. Read More

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http://dx.doi.org/10.1111/epi.13863DOI Listing
October 2017
9 Reads

Profile of neonatal epilepsies: Characteristics of a prospective US cohort.

Neurology 2017 Aug 21;89(9):893-899. Epub 2017 Jul 21.

From the Department of Pediatrics & Communicable Diseases (R.A.S.), University of Michigan, Ann Arbor; Departments of Neurology & Pediatrics (C.J.W.), Stanford University, Palo Alto, CA; Department of Neurology (T.N.T., N.W.), Children's National Health System, George Washington University School of Medicine, Washington, DC; Departments of Neurology and Pediatrics (H.C.G., M.R.C.), UCSF Benioff Children's Hospital, and Department of Epidemiology & Biostatistics (H.C.G.), University of California San Francisco; Department of Neurology (C.J.C.), Massachusetts General Hospital, Boston; Departments of Neurology and Pediatrics (S.L.M., N.S.A.), The Children's Hospital of Philadelphia and The Perelman School of Medicine at the University of Pennsylvania; and Department of Neurology (J.S.S.), Boston Children's Hospital, MA.

Objective: Although individual neonatal epilepsy syndromes are rare, as a group they represent a sizable subgroup of neonatal seizure etiologies. We evaluated the profile of neonatal epilepsies in a prospective cohort of newborns with seizures.

Methods: Consecutive newborns with seizures were enrolled in the Neonatal Seizure Registry (an association of 7 US children's hospitals). Read More

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http://dx.doi.org/10.1212/WNL.0000000000004284DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5577964PMC
August 2017
5 Reads

Pretreatment seizure semiology in childhood absence epilepsy.

Neurology 2017 Aug 19;89(7):673-679. Epub 2017 Jul 19.

From the Children's Hospital of Philadelphia (S.K.K., D.D.), Perelman School of Medicine, University of Pennsylvania; Montefiore Medical Center (S.S., S.L.M.), Albert Einstein College of Medicine, Bronx, NY; Children's National Health System (A.C., J.C., F.H.), Washington, DC; National Institute of Neurological Disorders and Stroke (D.G.H.), Bethesda, MD; Comprehensive Epilepsy Center (C.L., P.C., T.A.G.), Division of Neurology, Cincinnati Children's Hospital Medical Center, OH; and Baylor College of Medicine (E.M.M.), Houston, TX.

Objective: To determine seizure semiology in children with newly diagnosed childhood absence epilepsy and to evaluate associations with short-term treatment outcomes.

Methods: For participants enrolled in a multicenter, randomized, double-blind, comparative-effectiveness trial, semiologic features of pretreatment seizures were analyzed as predictors of treatment outcome at the week 16 to 20 visit.

Results: Video of 1,932 electrographic absence seizures from 416 participants was evaluated. Read More

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http://www.neurology.org/lookup/doi/10.1212/WNL.000000000000
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http://dx.doi.org/10.1212/WNL.0000000000004226DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5562968PMC
August 2017
16 Reads

Mouse epileptic seizure detection with multiple EEG features and simple thresholding technique.

J Neural Eng 2017 Dec;14(6):066006

Centre for Advanced Imaging, The University of Queensland, Brisbane, Queensland, Australia.

Objective: Epilepsy is a common neurological disorder characterized by recurrent, unprovoked seizures. The search for new treatments for seizures and epilepsy relies upon studies in animal models of epilepsy. To capture data on seizures, many applications require prolonged electroencephalography (EEG) with recordings that generate voluminous data. Read More

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http://stacks.iop.org/1741-2552/14/i=6/a=066006?key=crossref
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http://dx.doi.org/10.1088/1741-2552/aa8069DOI Listing
December 2017
3 Reads

A clinical and neurophysiological motor signature of Unverricht-Lundborg disease.

Rev Neurol (Paris) 2018 Jan - Feb;174(1-2):56-65. Epub 2017 Jul 5.

Unité de neurophysiologie, département DéPAS, hôpital Saint-Antoine, AP-HP, 184, rue du Faubourg-Saint-Antoine, 75012 Paris, France; Inserm U1127, CNRS UMR7225, institut du cerveau et de la moelle épinière, ICM, Paris Sorbonne universités, UPMC, université de Paris 06, UMR S1127, 47, boulevard de l'hôpital, 75651 Paris cedex 13, France. Electronic address:

Objectives: Unverricht-Lundborg disease (ULD) is the most common form of progressive myoclonus epilepsy. Cerebellar dysfunction may appear over time, contributing along with myoclonus to motor disability. The purpose of the present work was to clarify the motor and neurophysiological characteristics of ULD patients. Read More

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http://dx.doi.org/10.1016/j.neurol.2017.06.005DOI Listing
November 2018
14 Reads

Seizure-associated aphasia has good lateralizing but poor localizing significance.

Epilepsia 2017 09 4;58(9):1551-1555. Epub 2017 Jul 4.

Department of Neurology, Epilepsy Center, University of Munich, Munich, Germany.

Objective: To investigate the occurrence of ictal and postictal aphasia in different focal epilepsy syndromes.

Methods: We retrospectively analyzed the video-electroencephalographic monitoring data of 1,118 patients with focal epilepsy for seizure-associated aphasia (SAA). Statistical analysis included chi-square analysis and Fisher's exact test. Read More

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http://dx.doi.org/10.1111/epi.13835DOI Listing
September 2017
2 Reads

Epileptic Encephalopathies as Neurodegenerative Disorders.

Adv Neurobiol 2017 ;15:295-315

Division of Child Neurology, The Children's Hospital of Philadelphia, 34th St and Civic Center Blvd, Philadelphia, PA, 19104, USA.

The epileptic encephalopathies are severe and often treatment-resistant conditions that are associated with a progressive disturbance of brain function, resulting in a broad range of neurological and non-neurological comorbidities. The concept of epileptic encephalopathies entails that the encephalopathy aspect of the overall condition is primarily driven by the epileptic activity of the disease, which often manifests as specific and pathological features on the electroencephalogram. Genetic factors in epileptic encephalopathies are increasingly recognized. Read More

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http://dx.doi.org/10.1007/978-3-319-57193-5_11DOI Listing
November 2018
8 Reads

De novo 12q22.q23.3 duplication associated with temporal lobe epilepsy.

Seizure 2017 Aug 15;50:80-82. Epub 2017 Jun 15.

Laboratory of Neurogenetics and Neuroscience, "G. Gaslini" Institute, Genova, Italy.

Purpose: Temporal lobe epilepsy (TLE) is the most common form of focal epilepsy and may be associated with acquired central nervous system lesions or could be genetic. Various susceptibility genes and environmental factors are believed to be involved in the aetiology of TLE, which is considered to be a heterogeneous, polygenic, and complex disorder. Rare point mutations in LGI1, DEPDC5, and RELN as well as some copy number variations (CNVs) have been reported in families with TLE patients. Read More

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http://dx.doi.org/10.1016/j.seizure.2017.06.011DOI Listing
August 2017
8 Reads

Role of Electroencephalography in the Diagnosis and Treatment of Neuropsychiatric Border Zone Syndromes.

Indian J Psychol Med 2017 May-Jun;39(3):243-249

Department of Psychiatry, National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka, India.

Border zone disorders involve neurological disorders with psychiatric symptoms and signs as well as psychiatric disorders with soft neurological features. This becomes a cause for great diagnostic and therapeutic concerns. We, in this paper, analyzed some of the imitators such as epilepsy, dementia, some forms of encephalitis, and pure psychiatric diseases which produce problems in decision making due to soft neurological features and the utility of electroencephalography (EEG) as a simple diagnostic tool in differentiating some of these conditions from each other as well as the therapeutic role of EEG in some of these disorders. Read More

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http://dx.doi.org/10.4103/0253-7176.207336DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5461831PMC
June 2017
2 Reads

Functional Network Connectivity Patterns between Idiopathic Generalized Epilepsy with Myoclonic and Absence Seizures.

Front Comput Neurosci 2017 23;11:38. Epub 2017 May 23.

Department of Neurology, First Affiliated Hospital of Hainan Medical UniversityHaikou, China.

The extensive cerebral cortex and subcortical structures are considered as the major regions related to the generalized epileptiform discharges in idiopathic generalized epilepsy. However, various clinical syndromes and electroencephalogram (EEG) signs exist across generalized seizures, such as the loss of consciousness during absence seizures (AS) and the jerk of limbs during myoclonic seizures (MS). It is presumed that various functional systems affected by discharges lead to the difference in syndromes of these seizures. Read More

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http://dx.doi.org/10.3389/fncom.2017.00038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5440462PMC
May 2017
13 Reads

Benign childhood epilepsy with centrotemporal spikes (BECTS) and developmental co-ordination disorder.

Epilepsy Behav 2017 07 7;72:122-126. Epub 2017 Jun 7.

Welsh Epilepsy Centre, University Hospital of Wales, Cardiff, UK. Electronic address:

Background: Benign epilepsy with centro-temporal spikes (BECTS) is a common childhood epilepsy syndrome also known as Rolandic Epilepsy (RE). Neurocognitive phenotypes have been described with greater focus on attention, reading and language domains but there have been far fewer studies focusing on motor functioning. This study included measures of motor, language and cognition in order to investigate the range, degree and pattern of difficulties associated with BECTS in a case series of children, but with a particular emphasis on motor skills. Read More

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http://dx.doi.org/10.1016/j.yebeh.2017.04.014DOI Listing
July 2017
41 Reads

Juvenile myoclonic epilepsy as a spectrum disorder: A focused review.

Seizure 2017 Jul 18;49:36-41. Epub 2017 May 18.

Danish Epilepsy Centre, Kolonivej 1, 4293 Dianalund, Denmark; Programa de Pós-Graduação em Ciências Médicas, Universidad Federal de Santa Catarina, Florianópolis, SC, Brazil. Electronic address:

In consequence of newer research juvenile myoclonic epilepsy (JME) is no longer seen as a homogeneous disease. The causes of the existing variance are only partially known yet. We discuss to what extent the phenotypical spectrum of this polygenetically determined disorder expresses genetically defined endophenotypes, or is due to mere quantitative differences in the expression of the core phenotype. Read More

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http://dx.doi.org/10.1016/j.seizure.2017.05.011DOI Listing
July 2017
13 Reads

Disease-Modifying Effects of Neural Regeneration Peptide 2945 in the GAERS Model of Absence Epilepsy.

Neurochem Res 2017 Jul 16;42(7):2055-2064. Epub 2017 May 16.

Department of Medicine (Royal Melbourne Hospital), Melbourne Brain Centre, University of Melbourne, Parkville, VIC, 3052, Australia.

Epilepsy is a common neurological condition characterised by spontaneous recurrent seizures. Current anti-epileptic drugs are only effective and tolerated in ~70% of patients, leaving a substantial proportion of patients untreated. As such, there is a pressing need to develop new therapies. Read More

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http://dx.doi.org/10.1007/s11064-017-2305-xDOI Listing
July 2017
8 Reads

Enriched environment attenuates behavioral seizures and depression in chronic temporal lobe epilepsy.

Epilepsia 2017 07 8;58(7):1148-1158. Epub 2017 May 8.

Department of Neurophysiology, National Institute of Mental Health and Neuro Sciences, Bengaluru, India.

Objective: Temporal lobe epilepsy (TLE) is commonly associated with depression, anxiety, and cognitive impairment. Despite significant progress in our understanding of the pathophysiology of TLE, it remains the most common form of refractory epilepsy. Enriched environment (EE) has a beneficial effect in many neuropsychiatric disorders. Read More

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http://dx.doi.org/10.1111/epi.13767DOI Listing
July 2017
31 Reads

The Characteristics and Long-Term Course of Epilepsy in Lipoid Proteinosis: A Spectrum From Mild to Severe Seizures in Relation to ECM1 Mutations.

Clin EEG Neurosci 2018 May 23;49(3):192-196. Epub 2017 Apr 23.

1 Departments of Neurology and Clinical Neurophysiology, Faculty of Medicine, Istanbul University, Istanbul, Turkey.

Lipoid proteinosis (LP) is a rare autosomal recessive disease characterized by deposition of hyaline material in skin and mucosae. Epilepsy, as an extracutaneous manifestation associated with typical mesial temporal calcifications, has already been identified, but its characteristics and long-term prognosis have not been thoroughly investigated. We included 7 consecutive patients with LP with typical intracranial calcifications out of 16 patients with ECM1 mutations and investigated the semiologic features, ictal and interictal EEG findings, and long-term prognosis of epilepsy in this genodermatosis. Read More

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http://journals.sagepub.com/doi/10.1177/1550059417705280
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http://dx.doi.org/10.1177/1550059417705280DOI Listing
May 2018
18 Reads

Acute Symptomatic Seizures in Geriatric Patients with Multiple Risk Factors - A Diagnostic Challenge.

Curr Aging Sci 2017 ;10(4):263-269

Klinik fur Neurologie, Westpfalz-Klinikum, Hellmut-Hartert-Str. 1, D-67655 Kaiserslautern. Germany.

Background: Acute symptomatic seizures and epileptic disorders are frequent health problems of elderly patients. An early and reliable distinction of the seizure etiology is important to ensure adequate treatment, and to prevent unwarranted diagnostic and therapeutic procedures.

Methods: We review the current literature based on a MEDLINE search, describe age-related problems in detail, with particular attention to clinical practice, discuss possible criteria and potential pitfalls for diagnostics, and provide a compilation of etiologic factors for acute symptomatic seizures. Read More

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http://dx.doi.org/10.2174/1874609810666170413123317DOI Listing
June 2018
9 Reads

Refractory Lesional Parietal Lobe Epilepsy: Clinical, Electroencephalographic and Neurodiagnostic Findings.

Noro Psikiyatr Ars 2016 Sep 1;53(3):213-221. Epub 2016 Mar 1.

Department of Neurology, Hacettepe University School of Medicine, Ankara, Turkey.

Introduction: Specialized centers, in the management and surgical treatment of medically refractory epilepsy, emphasize the importance of differentiating the varieties of localization related epilepsies. There has been considerable recent interest in temporal and frontal lobe epileptic syndromes and less attention has been paid to parietal and occipital lobe epilepsies.

Methods: Here we report the clinical, electroencephalographic and neuroimaging characteristics of 46 patients with medically refractory lesional parietal lobe epilepsy who have been followed up for 1-10 years. Read More

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http://dx.doi.org/10.5152/npa.2016.13790DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5378203PMC
September 2016
7 Reads

Epileptic Discharge Related Functional Connectivity Within and Between Networks in Benign Epilepsy with Centrotemporal Spikes.

Int J Neural Syst 2017 Nov 10;27(7):1750018. Epub 2017 Jan 10.

* Key Laboratory for Neuroinformation of Ministry of Education, Center for Information in BioMedicine, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 610054, P. R. China.

Benign epilepsy with centrotemporal spikes (BECTS) is a common childhood epilepsy syndrome associated with abnormalities in neurocognitive domains, particularly during interictal epileptiform discharges (IEDs). Here, we investigated the effects of IEDs on brain's intrinsic connectivity networks in 43 BECTS patients and 28 matched healthy controls (HCs). Patients were further divided into IED and non-IED subgroups based on simultaneous EEG-fMRI recordings. Read More

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http://dx.doi.org/10.1142/S0129065717500186DOI Listing
November 2017
14 Reads

A Mesiotemporal Lobe Epilepsy Mouse Model.

Neurochem Res 2017 Jul 23;42(7):1919-1925. Epub 2017 Mar 23.

SynapCell SAS, Bâtiment Biopolis, 5 Avenue du Grand Sablon, 38700, La Tronche, France.

Among the different forms of epilepsies, mesiotemporal lobe epilepsy (MTLE) is one of the most common and represents the main pharmaco-resistant form of epilepsy. There is therefore an urgent need to better understand this form of epilepsy to develop better anti-epileptic drugs. Many rodent models are mimicking some aspects of the human temporal lobe epilepsy but only few are addressing most of the human mesiotemporal lobe epilepsy. Read More

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http://dx.doi.org/10.1007/s11064-017-2239-3DOI Listing
July 2017
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Epileptic spasms in congenital disorders of glycosylation.

Epileptic Disord 2017 Mar;19(1):15-23

Department of Clinical Neurophysiology, Necker Enfants Malades Hospital, Paris, INSERM U1129, Paris, France; Paris Descartes University, CEA, Gif sur Yvette, Paris, France.

Congenital disorders of glycosylation (CDG) are a group of rare metabolic diseases, characterized by impaired glycosylation. Multisystemic involvement is common and neurological impairment is notably severe and disabling, concerning the central and peripheral nervous system. Epilepsy is frequent, but detailed electroclinical description is rare. Read More

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http://dx.doi.org/10.1684/epd.2017.0901DOI Listing
March 2017
27 Reads

Blood DNA methylation pattern is altered in mesial temporal lobe epilepsy.

Sci Rep 2017 03 9;7:43810. Epub 2017 Mar 9.

Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China.

Mesial temporal lobe epilepsy (MTLE) is a common epileptic disorder; little is known whether it is associated with peripheral epigenetic changes. Here we compared blood whole genomic DNA methylation pattern in MTLE patients (n = 30) relative to controls (n = 30) with the Human Methylation 450 K BeadChip assay, and explored genes and pathways that were differentially methylated using bioinformatics profiling. The MTLE and control groups showed significantly different (P < 1. Read More

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http://dx.doi.org/10.1038/srep43810DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5343463PMC
March 2017
7 Reads
5.080 Impact Factor

Effect of temperature on sleep regulation in an animal epilepsy model.

Conf Proc IEEE Eng Med Biol Soc 2016 08;2016:1644-1647

Besides recurring seizures, disordered sleep is common in individuals with epilepsy and may present as reduced sleep depth, altered proportions of different stages of sleep, intermittent arousal, and other phenomena. Sleep loss can in turn precipitate seizures, thus sustaining a vicious cycle. It is well known that changes in ambient temperature elicit thermoregulatory responses that alter the dynamics of sleep. Read More

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http://dx.doi.org/10.1109/EMBC.2016.7591029DOI Listing
August 2016
2 Reads

MRI-negative temporal lobe epilepsy-What do we know?

Epilepsia 2017 05 7;58(5):727-742. Epub 2017 Mar 7.

University of California San Francisco (UCSF), San Francisco, California, U.S.A.

Temporal lobe epilepsy (TLE) is the most common focal epilepsy in adults. TLE has a high chance of becoming medically refractory, and as such, is frequently considered for further evaluation and surgical intervention. Up to 30% of TLE cases, however, can have normal ("nonlesional" or negative) magnetic resonance imaging (MRI) results, which complicates the presurgical workup and has been associated with worse surgical outcomes. Read More

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http://dx.doi.org/10.1111/epi.13699DOI Listing
May 2017
7 Reads

Atypical features of benign rolandic epilepsy in Chinese children: Retrospective study.

Pediatr Int 2017 Jul;59(7):793-797

Department of Neurology, Qilu Hospital, Shandong University, Jinan, Shandong, China.

Background: Benign rolandic epilepsy (BRE) is one of the most common focal epilepsies in childhood, but less typical clinical presentations may lead to misdiagnosis and incorrect treatment. The focus of this study was therefore to retrospectively investigate the less typical features of BRE in Chinese children.

Methods: Data on 316 Chinese children with BRE were collected and analyzed. Read More

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http://dx.doi.org/10.1111/ped.13274DOI Listing
July 2017
12 Reads