3,367 results match your criteria EEG in Brain Tumors


Neurological toxicities associated with chimeric antigen receptor T-cell therapy.

Brain 2019 Mar 19. Epub 2019 Mar 19.

Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

Chimeric antigen receptor T cell therapy has become an important tool in the treatment of relapsed and refractory malignancy; however, it is associated with significant neurological toxicity. We characterized the neurological toxicity associated with chimeric antigen receptor T-cell therapy in a consecutive series of 100 patients up to 2 months post transfusion, 28 of whom were obtained from chart review and the others by prospective observation. The underlying neoplasms were lymphoma (74%), myeloma (14%), leukaemia (10%), and sarcoma (2%). Read More

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http://dx.doi.org/10.1093/brain/awz053DOI Listing
March 2019
3 Reads
9.196 Impact Factor

Variations in electroencephalography with mobile phone usage in medical students.

Neurol India 2019 Jan-Feb;67(1):235-241

Department of Neurology, King George's Medical University, Lucknow, Uttar Pradesh, India.

Background: Electromagnetic fields (EMFs) emitted by cellular telephones may cause neurological ill effects like cognitive dysfunction, emotional instability, and even brain tumors. Slowing of brain activity on electroencephalography (EEG) has been shown. However, these findings need further validation. Read More

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http://dx.doi.org/10.4103/0028-3886.253610DOI Listing
March 2019
4 Reads

Diagnostic and therapeutic values of intraoperative electrophysiological neuromonitoring during resection of intradural extramedullary spinal tumors: a single-center retrospective cohort and meta-analysis.

J Neurosurg Spine 2019 Mar 1:1-11. Epub 2019 Mar 1.

1Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, Maryland.

OBJECTIVEWith the advent of intraoperative electrophysiological neuromonitoring (IONM), surgical outcomes of various neurosurgical pathologies, such as brain tumors and spinal deformities, have improved. However, its diagnostic and therapeutic value in resecting intradural extramedullary (ID-EM) spinal tumors has not been well documented in the literature. The objective of this study was to summarize the clinical results of IONM in patients with ID-EM spinal tumors. Read More

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http://dx.doi.org/10.3171/2018.11.SPINE181095DOI Listing
March 2019
3 Reads

[Clinical analysis of 71 cases of anti-N-methyl-D-aspartate receptor encephalitis in children].

Zhonghua Er Ke Za Zhi 2019 Feb;57(2):125-130

Department of Pediatrics, Xiangya Hospital of Central South University, Hunan Intellectual and Developmental Disabilities Research Center, Changsha 410008, China.

To investigate the clinical features, treatment strategies and long term outcomes of children with anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis. The data of clinical features, auxiliary examinations, treatments and prognosis in children with anti-NMDAR encephalitis in Xiangya Hospital of Central South University from March 2014 to October 2017 were collected and retrospectively analyzed. A total of 71 patients were enrolled, including 33 males and 38 females. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0578-1310.2019.02.012DOI Listing
February 2019

A miniature multi-contrast microscope for functional imaging in freely behaving animals.

Nat Commun 2019 01 9;10(1):99. Epub 2019 Jan 9.

Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.

Neurovascular coupling, cerebrovascular remodeling and hemodynamic changes are critical to brain function, and dysregulated in neuropathologies such as brain tumors. Interrogating these phenomena in freely behaving animals requires a portable microscope with multiple optical contrast mechanisms. Therefore, we developed a miniaturized microscope with: a fluorescence (FL) channel for imaging neural activity (e. Read More

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http://dx.doi.org/10.1038/s41467-018-07926-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327063PMC
January 2019
2 Reads

The Resistivity of Human Brain Tumours In Vivo.

Authors:
J Latikka H Eskola

Ann Biomed Eng 2019 Mar 4;47(3):706-713. Epub 2019 Jan 4.

Faculty of Biomedical Sciences and Engineering, Tampere University of Technology, Tampere, Finland.

The histological structure of tumour tissues differs from healthy brain tissues. It can therefore be assumed that there are differences also in the electrical characteristics of these tissues. The electrical characteristics of the tissues define how electric current is distributed within volume conductors, such as the human body or head. Read More

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http://dx.doi.org/10.1007/s10439-018-02189-7DOI Listing
March 2019
5 Reads

The Influence of Anesthesia on Corticocortical Evoked Potential Monitoring Network Between Frontal and Temporoparietal Cortices.

World Neurosurg 2019 Mar 18;123:e685-e692. Epub 2018 Dec 18.

Department of Neurosurgery, Sapporo Medical University, Sapporo, Hokkaido, Japan. Electronic address:

Background: Previous studies have reported the usefulness of intraoperative corticocortical evoked potentials (CCEPs) for preserving language function during brain surgery.

Objective: This study aimed to assess the influence of depth of anesthesia on CCEP to establish its clinical utility.

Methods: Twenty patients with brain tumors or epilepsy who underwent awake craniotomy were included in this study. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18788750183282
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http://dx.doi.org/10.1016/j.wneu.2018.11.253DOI Listing
March 2019
20 Reads

Surgical strategy for temporal lobe epilepsy with dual pathology and incomplete evidence from EEG and neuroimaging.

Exp Ther Med 2018 Dec 19;16(6):4886-4892. Epub 2018 Sep 19.

Department of Neurosurgery, The Second Hospital of Dalian Medical University, Dalian, Liaoning 116000, P.R. China.

Coexistence of hippocampal sclerosis (HS) and a temporal neocortical lesion, including focal cortical dysplasia, vascular malformations or benign primary brain tumors, is defined as dual pathology. In the majority of cases, the complete evidence based on electroencephalogram (EEG) and magnetic resonance imaging (MRI) for each of the dual pathological lesions is difficult to obtain. As a result, patients with dual pathology are poor surgical candidates due to potential incomplete resection of the epileptogenic zone. Read More

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http://dx.doi.org/10.3892/etm.2018.6774DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6256846PMC
December 2018

Age-dependent semiology of frontal lobe seizures.

Epilepsy Res 2019 01 23;149:83-87. Epub 2018 Oct 23.

Epilepsy Center, University Medical Center, University of Freiburg, Germany; Faculty of Medicine, University of Freiburg, Germany. Electronic address:

Introduction: Frontal lobe epilepsy is the second most frequent origin of focal epilepsy. Various studies have discussed localizing aspects of ictal signs in frontal lobe epilepsy; the effect of age on semiological manifestations has, however, not been analyzed so far.

Material And Methods: We retrospectively analyzed video-documented semiological signs in a cohort of 122 consecutive patients aged 0-70 years (mean age: 24. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09201211183040
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http://dx.doi.org/10.1016/j.eplepsyres.2018.10.007DOI Listing
January 2019
28 Reads

Histopathologic and Clinical Correlation of Aberrant Neuromagnetic Activities with Low to High Frequency of Gliomas.

World Neurosurg 2019 Mar 8;123:e609-e620. Epub 2018 Dec 8.

Department of Neurosurgery, the First Affiliated Hospital of Nanjing Medical University, Nanjing, China. Electronic address:

Objective: To quantify the low- to high-frequency range of abnormal brain activities and assess the histopathologic and clinical correlation in patients with glioma.

Methods: Twenty-five patients with glioma and 20 healthy controls were examined with a magnetoencephalography (MEG) system. MEG data collected in 6 frequency bands, including 1-4 Hz, 4-8 Hz, 8-12 Hz, 12-30 Hz, 30-45 Hz, and 55-75 Hz, were analyzed by neuropathology to assess neuromagnetic signatures of glioma grade. Read More

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http://dx.doi.org/10.1016/j.wneu.2018.11.235DOI Listing
March 2019
1 Read

Migraine-like visual aura: Can it be an early-onset symptom of astrocytoma?

Agri 2018 Oct;30(4):202-205

Department of Neurology, Kocaeli Derince Training and Research Hospital, Kocaeli, Turkey.

Photopsia, fortification spectra, and the slow propagation of a scintillating scotoma across the visual field are typical diagnostic features of the visual aura of migraine. In the vast majority of cases, the diagnosis can be made without the need for further investigations. Herein, we report three consecutive cases with an astrocytoma and discuss clinical features of migraine-like visual aura. Read More

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http://dx.doi.org/10.5505/agri.2017.77598DOI Listing
October 2018
3 Reads

Ictal SPECT reveals different epileptogenic zones in frontal lobe epilepsy.

Epileptic Disord 2018 Oct;20(5):447-450

Epilepsy Center, Department of Neurology, University of Munich, Munich, Germany.

We report a patient with frontal lobe epilepsy due to a right frontal astrocytoma (WHO Grade III) in whom two ictal SPECTs (single photon emission tomography) were performed during two seizures with different semiology and different EEG seizure patterns. Subtraction of ictal and interictal SPECT showed right lateral frontal hyperperfusion during a left face clonic seizure, and right mesial fronto-polar hyperperfusion during a subclinical seizure. This report demonstrates that ictal SPECT may reflect different seizure semiology from the frontal lobe of the same individual and that simultaneous EEG is indispensable for the correct interpretation of SPECT in epilepsy. Read More

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http://dx.doi.org/10.1684/epd.2018.0991DOI Listing
October 2018
18 Reads

CD34 Expression in Low-Grade Epilepsy-Associated Tumors: Relationships with Clinicopathologic Features.

World Neurosurg 2019 Jan 9;121:e761-e768. Epub 2018 Oct 9.

Neurosurgery Unit, Department of Neuroscience, Bambino Gesù Children's Hospital IRCCS, Rome, Italy.

Objective: To analyze relationships between CD34 expression and several demographic, clinical, and pathologic features in patients with histopathologic evidence of low-grade epilepsy-associated tumors who underwent epilepsy surgery.

Methods: A retrospective study enrolling 187 patients with low-grade epilepsy-associated tumors who underwent surgery between January 2009 and June 2015 at 8 Italian epilepsy surgery centers was conducted. All cases were histologically diagnosed according to the World Health Organization classification of central nervous system tumors. Read More

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http://dx.doi.org/10.1016/j.wneu.2018.09.212DOI Listing
January 2019
5 Reads

Hypermetabolism Caused by Seizure Mimicking Tumor Recurrence.

Clin Nucl Med 2018 Dec;43(12):930-932

Neurology, Chinese Academy of Medical Sciences and Peking Union Medical College Hospital, Beijing, China.

A 41-year-old man had a right frontal grade I glioma resection 17 years ago. He was tumor free since. However, 1 month ago, he presented with an uncontrollable seizure, which raised the possibility of recurrent tumor. Read More

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http://Insights.ovid.com/crossref?an=00003072-900000000-9743
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http://dx.doi.org/10.1097/RLU.0000000000002305DOI Listing
December 2018
2 Reads

Can Early Postoperative O-(2-Fluoroethyl)-l-Tyrosine Positron Emission Tomography After Resection of Glioblastoma Predict the Location of Later Tumor Recurrence?

World Neurosurg 2019 Jan 27;121:e467-e474. Epub 2018 Sep 27.

Department of Neurosurgery, Klinikum Rechts der Isar, Technische Universität München, Munich, Germany; Department of Neurosurgery, Universitätsmedizin der Johannes Gutenberg Universität Mainz, Mainz, Germany.

Objective: Glioblastoma inevitably recurs despite aggressive therapy. Therefore, it would be helpful to predict the location of tumor recurrence from postoperative imaging to customize further treatment. O-(2-fluoroethyl)-l-tyrosine (FET) positron emission tomography (PET) might be a helpful technique, because tumor tissue can be differentiated from normal brain tissue with high specificity. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18788750183218
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http://dx.doi.org/10.1016/j.wneu.2018.09.139DOI Listing
January 2019
2 Reads

Seizure characteristics are related to tumor pathology in children with brain tumors.

Epilepsy Res 2018 11 23;147:15-21. Epub 2018 Aug 23.

Pediatric Brain Tumor Program, Taipei Cancer Center, Taipei Medical University, Taipei, Taiwan; Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan; Division of Pediatric Neurosurgery, Department of Neurosurgery, Taipei Medical University Hospital, Taipei, Taiwan; Neuroscience Research Center, Taipei Medical University Hospital, Taipei, Taiwan. Electronic address:

Objectives: Brain tumors are found in 1-3% of children with newly onset of seizures. Understanding the impact of seizures on pediatric brain tumors and factors between seizures and brain tumors are crucial. This study aimed to evaluate the association of pediatric brain tumors on seizure occurrence and the relationships between seizures and the diagnosis and prognosis of brain tumors. Read More

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http://dx.doi.org/10.1016/j.eplepsyres.2018.08.007DOI Listing
November 2018
5 Reads

Parenteral phenobarbital in status epilepticus revisited: Mayo Clinic experience.

Epilepsia 2018 10 29;59 Suppl 2:193-197. Epub 2018 Aug 29.

Department of Neurology, Mayo Clinic, Rochester, MN, USA.

Despite phenobarbital (PB) being a key component in status epilepticus (SE) treatment algorithms for decades, it has fallen out of favor compared to newer nonsedating medications due to potential for respiratory suppression and prolonged sedation. We retrospectively analyzed all nonintubated patients with refractory SE treated with parenteral PB. Forty patients were identified as having received PB in the neurologic intensive care unit at Mayo Clinic over a 7-year period through our pharmacy dispensing database. Read More

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http://doi.wiley.com/10.1111/epi.14488
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http://dx.doi.org/10.1111/epi.14488DOI Listing
October 2018
24 Reads

Susceptibility to hippocampal kindling seizures is increased in aging C57 black mice.

IBRO Rep 2017 Dec 24;3:33-44. Epub 2017 Sep 24.

Krembil Research Institute, University Health Network, Canada.

The incidence of seizures increases with old age. Stroke, dementia and brain tumors are recognized risk factors for new-onset seizures in the aging populations and the incidence of these conditions also increased with age. Whether aging is associated with higher seizure susceptibility in the absence of the above pathologies remains unclear. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S24518301173002
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http://dx.doi.org/10.1016/j.ibror.2017.08.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6084868PMC
December 2017
27 Reads

Oscillatory brain activity associates with neuroligin-3 expression and predicts progression free survival in patients with diffuse glioma.

J Neurooncol 2018 Nov 9;140(2):403-412. Epub 2018 Aug 9.

Department of Anatomy & Neurosciences, VU University Medical Center, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands.

Introduction: Diffuse gliomas have local and global effects on neurophysiological brain functioning, which are often seen as 'passive' consequences of the tumor. However, seminal preclinical work has shown a prominent role for neuronal activity in glioma growth: mediated by neuroligin-3 (NLGN3), increased neuronal activity causes faster glioma growth. It is unclear whether the same holds true in patients. Read More

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http://dx.doi.org/10.1007/s11060-018-2967-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6244774PMC
November 2018
3 Reads

Dense array EEG estimated the epileptic focus in a patient with epilepsy secondary to tuberous sclerosis complex.

Brain Dev 2019 Jan 1;41(1):116-120. Epub 2018 Aug 1.

Facility Comprehensive Epilepsy Center, Seirei Hamamatsu General Hospital, Japan.

Purpose: Tuberous sclerosis complex (TSC) is a leading cause of epilepsy, with seizures affecting almost 80-90% of children. We used the concordance between magnetic resonance imaging (MRI) and dense array electroencephalography (dEEG) findings to detect epileptic focus in a patient with TSC.

Methods: A 9-year-old boy with TSC exhibited daily choking spells. Read More

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http://dx.doi.org/10.1016/j.braindev.2018.07.010DOI Listing
January 2019
5 Reads

Seizures with Migraine-like Attacks after Radiation Therapy (SMART): A new meaning of an old acronym.

Seizure 2018 Aug 18;60:94-95. Epub 2018 Jun 18.

Department of Medical and Surgical Sciences, Magna Graecia University, Viale Europa, Catanzaro, Italy; Regional Epilepsy Centre, Great Metropolitan Hospital, Via Melacrino, Reggio Calabria, Italy; Institute of Molecular Bioimaging and Physiology, National Research Council, Viale Europa, Catanzaro, Italy. Electronic address:

Stroke-like migraine attacks after radiation therapy (SMART) is a late-onset complication of cerebral irradiation, clinically characterized by headache, seizures and focal deficits. We describe two patients with SMART presenting with focal status epilepticus and headache. We believe that SMART is a misnomer that misjudge seizures among clinical features and we suggest to rename this entity as " Seizure with Migraine-like Attacks after Radiation Therapy". Read More

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http://dx.doi.org/10.1016/j.seizure.2018.06.014DOI Listing
August 2018
4 Reads

Alterations of EEG rhythms during motor preparation following awake brain surgery.

Brain Cogn 2018 08 2;125:45-52. Epub 2018 Jun 2.

CAMIN Team, INRIA, LIRMM, Université de Montpellier, 34095 Montpellier, France; Cognition, Action et Plasticité Sensorimotrice, INSERM U1093, UFR STAPS, Université Bourgogne Franche-Comté, 21078 Dijon, France; Institut Universitaire de France, 75231 Paris, France. Electronic address:

Slow-growing, infiltrative brain tumours may modify the electrophysiological balance between the two hemispheres. To determine whether and how asymmetry of EEG rhythms during motor preparation might occur following "awake brain surgery" for this type of tumour, we recorded electroencephalograms during a simple visuo-manual reaction time paradigm performed by the patients between 3 and 12 months after surgery and compared them to a control group of 8 healthy subjects. Frequency analyses revealed imbalances between the injured and healthy hemispheres. Read More

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http://dx.doi.org/10.1016/j.bandc.2018.05.010DOI Listing
August 2018
2 Reads

[Analysis of olfactory dysfunction after endoscopic and microscopic endonasal transsphenoidal surgery for pituitary adenoma].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2017 Oct;31(19):1512-1518

Department of Neurosurgery,General Hospital of Ningxia Medical University,Yinchuan,750001,China.

To analyze the clinical data of patients with olfactory dysfunction after endoscopic or microscopic endonasal transsphenoidal approach,and to screen out the possible related factors,to guide clinical diagnosis and treatment,and to improve the patients' quality of life.In the retrospective study,we analyze patients' data,and follow up them with telephone,records the olfactory levels before and after surgery. In the prospective study,five odors were applied to test the olfactory function before the surgery,then one week,3 weeks and 6 weeks after that. Read More

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http://www.cnki.net/kcms/doi/10.13201/j.issn.1001-1781.2017.
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http://dx.doi.org/10.13201/j.issn.1001-1781.2017.19.012DOI Listing
October 2017
1 Read

Cutaneous Manifestations of Tuberous Sclerosis.

Acta Dermatovenerol Croat 2018 Apr;26(1):73-74

Vladimir Prelević, MD, Clinic for Nephrology Clinical Center of Montenegro, Ljubljanska bb 81101 Podgorica, Montenegro;

Dear Editor, Tuberous sclerosis (TS) is an autosomal dominant multisystem disease, which occurs due to genetically determined hyperplasia of ectodermal and mesodermal cells. Clinical manifestations present on the skin and in the nervous system, kidneys, heart, and other organs. Recent studies estimate the incidence of TS at 1/6000 to 1/10,000 live births, and a prevalence in the general population of approximately 1 in 20,000 (1). Read More

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April 2018
27 Reads

Neuronavigation-Guided Corticospinal Tract Mapping in Brainstem Tumor Surgery: Better Preservation of Motor Function.

World Neurosurg 2018 Aug 4;116:e291-e297. Epub 2018 May 4.

Beijing Neurosurgical Institute, Capital Medical University, Beijing, China; Department of Neuroelectrophysiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China. Electronic address:

Objective: To evaluate a new technique in brainstem surgery, neuronavigation (NN)-guided corticospinal tract (CST) mapping, in a retrospective study of patients undergoing brainstem tumor surgery.

Methods: We studied 40 patients with a brainstem tumor who were enrolled in this study. Patients whose worst preoperative muscle strength of the 4 limbs was greater than 3 levels from normal on the Lovett scale were divided into 2 groups: a treatment group of 21 patients who underwent NN-guided CST mapping and routine intraoperative neurophysiology monitoring (IONM) and a control group of 19 patients who underwent routine NN and IONM. Read More

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http://dx.doi.org/10.1016/j.wneu.2018.04.189DOI Listing
August 2018
12 Reads

Intracranial Space-occupying Lesion Inducing Intracranial Hypertension Increases the Encephalographic Effects of Isoflurane in a Swine Model.

J Neurosurg Anesthesiol 2019 Jan;31(1):70-75

Department of Anesthesiology and Intensive Care, Hamamatsu University School of Medicine, Handayama, Hamamatsu, Japan.

Background: Patients with a brain tumor are susceptible to the hypnotic effect of anesthetics depending on the tumor's size. We investigated whether intracranial space-occupying lesions (ICSOLs) inducing intracranial hypertension increase isoflurane's effect on electroencephalographic (EEG) results.

Materials And Methods: After anesthetic induction with isoflurane, 11 swine were studied with regard to isoflurane's effect on EEGs at 0. Read More

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http://dx.doi.org/10.1097/ANA.0000000000000503DOI Listing
January 2019
4 Reads

Continuous Electroencephalography in the Critically Ill: Clinical and Continuous Electroencephalography Markers for Targeted Monitoring.

J Clin Neurophysiol 2018 Jul;35(4):325-331

Cleveland Clinic, Epilepsy Center, Neurological Institute, Cleveland, Ohio, U.S.A.

Purpose: Electrographic seizures detected by continuous electroencephalography (CEEG) in critically ill patients with altered mental status is becoming increasingly recognized. Data guiding the appropriate selection of patients to be monitored on CEEG are lacking. The aims of this article were to study the incidence of seizures in the critical care setting and to evaluate for clinical predictors to improve the efficiency of CEEG monitoring. Read More

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http://dx.doi.org/10.1097/WNP.0000000000000475DOI Listing
July 2018
5 Reads

Time rescaling reproduces EEG behavior during transition from propofol anesthesia-induced unconsciousness to consciousness.

Sci Rep 2018 Apr 16;8(1):6015. Epub 2018 Apr 16.

Institut de Neurosciences des Systèmes - Inserm UMR1106 - Aix-Marseille Université - Faculté de Médecine, 27, Boulevard Jean Moulin, 13005, Marseille, France.

General anesthesia (GA) is a reversible manipulation of consciousness whose mechanism is mysterious at the level of neural networks leaving space for several competing hypotheses. We recorded electrocorticography (ECoG) signals in patients who underwent intracranial monitoring during awake surgery for the treatment of cerebral tumors in functional areas of the brain. Therefore, we recorded the transition from unconsciousness to consciousness directly on the brain surface. Read More

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http://dx.doi.org/10.1038/s41598-018-24405-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5902625PMC
April 2018
2 Reads

Lateral prefrontal cortex lesion impairs regulation of internally and externally directed attention.

Neuroimage 2018 07 28;175:91-99. Epub 2018 Mar 28.

Helen Wills Neuroscience Institute, University of California - Berkeley, 132 Barker Hall, Berkeley, CA, 94720, USA; Department of Psychology, University of California - Berkeley, 130 Barker Hall, Berkeley, CA, 94720, USA. Electronic address:

Our capacity to flexibly shift between internally and externally directed attention is crucial for successful performance of activities in our daily lives. Neuroimaging studies have implicated the lateral prefrontal cortex (LPFC) in both internally directed processes, including autobiographical memory retrieval and future planning, and externally directed processes, including cognitive control and selective attention. However, the causal involvement of the LPFC in regulating internally directed attention states is unknown. Read More

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http://dx.doi.org/10.1016/j.neuroimage.2018.03.063DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5960633PMC
July 2018
5 Reads

Seizures in children with neurofibromatosis type 1: is neurofibromatosis type 1 enough?

Ital J Pediatr 2018 Mar 22;44(1):41. Epub 2018 Mar 22.

Centro di Riferimento Pediatrico delle Neurofibromatosi, Dipartimento della Donna, del Bambino e di Chirurgia Generale e Specialistica, Università degli Studi della Campania "L. Vanvitelli", Caserta, Italy.

Background: Neurofibromatosis type 1 (NF1) is related to a generally increased prevalence of seizures. The mechanism underlying the increased predisposition to seizures has not been fully elucidated. The aim of the study was to evaluate the role of NF1 in seizures pathogenesis in a cohort of children with NF1 and seizures. Read More

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http://dx.doi.org/10.1186/s13052-018-0477-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5863905PMC
March 2018
8 Reads

Efficacy of microwave ablation versus radiofrequency ablation for the treatment of hepatocellular carcinoma in patients with chronic liver disease: a randomised controlled phase 2 trial.

Lancet Gastroenterol Hepatol 2018 05 2;3(5):317-325. Epub 2018 Mar 2.

Department of Radiology and Interventional Radiology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.

Background: Radiofrequency ablation is the recommended treatment for patients with hepatocellular carcinoma who have lesions smaller than 3 cm and are therefore not candidates for surgery. Microwave ablation is a more recent technique with certain theoretical advantages that have not yet been confirmed clinically. We aimed to compare the efficacy of both techniques in the treatment of hepatocellular carcinoma lesions of 4 cm or smaller. Read More

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http://dx.doi.org/10.1016/S2468-1253(18)30029-3DOI Listing
May 2018
5 Reads

A case report of limbic encephalitis in a metastatic colon cancer patient during first-line bevacizumab-combined chemotherapy.

Medicine (Baltimore) 2018 Mar;97(9):e0011

Department of Clinical Medicine and Surgery.

Rationale: Paraneoplastic limbic encephalitis (PLE) is one of the most common causes of neurologic paraneoplastic syndromes, with unclear pathogenesis. While several reports published in the last decades showed the occurrence of PLE in a variety of cancers, only a few cases have been associated with colon cancer.

Patient Concerns: In February 2017, a 54-year-old man with clinical history of radically resected colon cancer started first line chemotherapy with FOLFOXIRI plus bevacizumab, after radiological diagnosis of multiple liver and bone metastases. Read More

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http://dx.doi.org/10.1097/MD.0000000000010011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5851735PMC
March 2018
14 Reads

New clinicopathological associations and histoprognostic markers in ILAE types of hippocampal sclerosis.

Brain Pathol 2018 09 10;28(5):644-655. Epub 2018 Apr 10.

Department of Neuropathology, AP-HP, Hôpitaux Universitaires Pitié-Salpêtrière Charles Foix, Paris, France.

Mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE-HS) is a heterogeneous syndrome. Surgery results in seizure freedom for most pharmacoresistant patients, but the epileptic and cognitive prognosis remains variable. The 2013 International League Against Epilepsy (ILAE) histopathological classification of hippocampal sclerosis (HS) has fostered research to understand MTLE-HS heterogeneity. Read More

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http://dx.doi.org/10.1111/bpa.12596DOI Listing
September 2018
15 Reads

Changes of the brain's bioelectrical activity in cognition, consciousness, and some mental disorders.

Med J Islam Repub Iran 2017;31:53. Epub 2017 Sep 3.

Department of Neurosciences, School of Advanced Medical Technologies, Tehran University of Medical Sciences, Tehran, Iran.

An electroencephalogram (EEG) is an accepted method in neurophysiology with a wide application. Different types of brain rhythms indicate that simultaneous activity of the brain cortex neurons depend on the person's mental state. we have focus on reviewing the existing literature pertaining to changes of the brain's bioelectrical activity that recorded from the scalp in different conditions such as cognition and some mental disorders. Read More

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http://dx.doi.org/10.14196/mjiri.31.53DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5804435PMC
September 2017
8 Reads

Status Epilepticus: Behavioral and Electroencephalography Seizure Correlates in Kainate Experimental Models.

Front Neurol 2018 23;9. Epub 2018 Jan 23.

Epilepsy Research Laboratory, Department of Biomedical Sciences, College of Veterinary Medicine, Iowa State University, Ames, IA, United States.

Various etiological factors, such as head injury, chemical intoxication, tumors, and gene mutation, can induce epileptogenesis. In animal models, (SE) triggers epileptogenesis. In humans, convulsive SE for >30 min can be a life-threatening medical emergency. Read More

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http://journal.frontiersin.org/article/10.3389/fneur.2018.00
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http://dx.doi.org/10.3389/fneur.2018.00007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5787145PMC
January 2018
8 Reads

Performance monitoring in lung cancer patients pre- and post-chemotherapy using fine-grained electrophysiological measures.

Neuroimage Clin 2018 28;18:86-96. Epub 2017 Dec 28.

Cognition and Brain Plasticity Group, Bellvitge Biomedical Research Institute-IDIBELL, L'Hospitalet de Llobregat, 08907 Barcelona, Spain.

No previous event-related potentials (ERPs) study has explored the error-related negativity (ERN) - an ERP component indexing performance monitoring - associated to cancer and chemotherapy-induced cognitive impairment in a lung cancer population. The aim of this study was to examine differences in performance monitoring in a small-cell lung cancer group (SCLC, C +) 1-month following chemotherapy and two control groups: a non-small cell lung cancer patient group (NSCLC, C -) prior to chemotherapy and a healthy control group (HC). Seventeen SCLC (C +) underwent a neuropsychological assessment and an ERP study using a flanker and a stop-signal paradigm. Read More

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http://dx.doi.org/10.1016/j.nicl.2017.12.032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5789765PMC
January 2019

Early diagnosis of tuberous sclerosis complex: a race against time. How to make the diagnosis before seizures?

Orphanet J Rare Dis 2018 01 29;13(1):25. Epub 2018 Jan 29.

Department of Neurology and Epileptology, The Children's Memorial Health Institute, Al. Dzieci Polskich 20, 04-730, Warszawa, Poland.

Background: Tuberous sclerosis complex (TSC) is a genetic disorder with an incidence of 1:6000 live births and associated with the development of benign tumors in several organs. It is also characterized by high rates of neurological and neuropsychiatric abnormalities, including epilepsy affecting 70-90% of patients and being one of the major risk factors of intellectual disability. The first seizures in TSC patients appear usually between the 4th and the 6th months of life. Read More

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https://ojrd.biomedcentral.com/articles/10.1186/s13023-018-0
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http://dx.doi.org/10.1186/s13023-018-0764-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5789613PMC
January 2018
23 Reads

The dysfunction of processing task-irrelevant emotional faces in pituitary patients: an evidence from expression-related visual mismatch negativity.

Neuroreport 2018 03;29(4):328-333

Evidence showed impaired cognitive ability of patients with pituitary adenoma as an intracranial tumor. In the present study, we investigated the preattentive processing of emotional faces in pituitary adenoma patients by recording and analyzing the visual mismatch negativity elicited by deviant emotional faces. In the normal control group, deviant emotional faces elicited expression-related mismatch negativity (EMMN), with a more pronounced negative waveform for sad than happy face conditions. Read More

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http://dx.doi.org/10.1097/WNR.0000000000000965DOI Listing
March 2018
11 Reads
1.640 Impact Factor

Need for surgical treatment of epilepsy and excision of tumors and post-traumatic epileptogenic lesions in Kinshasa, RDC.

Med Sante Trop 2017 Nov;27(4):415-420

Université de Gant, Belgique.

Surgery is a treatment to consider in epilepsy when the condition is refractory or epileptic events are related to a clearly identified brain abnormality. The tropical climate of the DRC explains the high risk of epilepsy and the potentially large number of refractory cases. The number of patients with epilepsy in Kinshasa is estimated to be at least 120 000, and almost one third may be refractory. Read More

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http://dx.doi.org/10.1684/mst.2017.0742DOI Listing
November 2017
7 Reads

Intractable epilepsy due to a rosette-forming glioneuronal tumor with a dysembryoplastic neuroepithelial background.

Neuropathology 2018 Jun 18;38(3):300-304. Epub 2017 Dec 18.

Department of Child Neurology, National Center Hospital, National Center of Neurology and Psychiatry (NCNP), Tokyo, Japan.

A rosette-forming glioneuronal tumor (RGNT) was initially reported as an infratentorial tumor that comprised both small neurocytic rosettes and astrocytic components. However, a few studies have reported supratentorial RGNTs arising in the cerebral hemispheres. Here, we report an unusual case involving a 9-year-old boy with a supratentorial RGNT who presented with intractable epilepsy and behavioral changes. Read More

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http://dx.doi.org/10.1111/neup.12450DOI Listing
June 2018
14 Reads

Seizure and cognitive outcomes after resection of glioneuronal tumors in children.

Epilepsia 2018 01 26;59(1):170-178. Epub 2017 Nov 26.

Great Ormond Street Hospital, London, United Kingdom.

Objective: Glioneuronal tumors (GNTs) are well-recognized causes of chronic drug-resistant focal epilepsy in children. Our practice involves an initial period of radiological surveillance and antiepileptic medications, with surgery being reserved for those with radiological progression or refractory seizures. We planned to analyze the group of patients with low-grade GNTs, aiming to identify factors affecting seizure and cognitive outcomes. Read More

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http://dx.doi.org/10.1111/epi.13961DOI Listing
January 2018
68 Reads

Brain tumors associated with psychogenic non-epileptic seizures: Case series.

Clin Neurol Neurosurg 2018 01 22;164:53-56. Epub 2017 Nov 22.

Department of Medicine, University of Kentucky, Lexington, KY, United States; Department of Neurology, University of Kentucky, Lexington, KY, United States; Department of Neurosurgery, University of Kentucky, Lexington, KY, United States; Markey Cancer Center, University of Kentucky, Lexington, KY, United States. Electronic address:

Objective: The association of psychogenic non-epileptic seizures (PNES) with primary or secondary brain tumors has not been well described in the literature. We aim to discuss their association, and their impact in brain tumor treatment.

Patients And Methods: We identified four patients retrospectively from our practice. Read More

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http://dx.doi.org/10.1016/j.clineuro.2017.11.013DOI Listing
January 2018
9 Reads

Surgical Management and Long-Term Seizure Outcome After Surgery for Temporal Lobe Epilepsy Associated with Cerebral Cavernous Malformations.

World Neurosurg 2018 Feb 22;110:e659-e670. Epub 2017 Nov 22.

Department of Epileptology, Fuzhou General Hospital, Fujian Medical University, Fuzhou, China.

Objective: Operative strategies for cerebral cavernous malformation (CCM)-associated temporal lobe epilepsy and timing of surgical intervention continue to be debated. This study aimed to establish an algorithm to evaluate the efficacy of surgical intervention strategies, to maximize positive surgical outcomes and minimize postsurgical neurologic deficits.

Methods: 47 patients having undergone operation for CCM-associated temporal lobe epilepsy were retrospectively reviewed. Read More

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http://dx.doi.org/10.1016/j.wneu.2017.11.067DOI Listing
February 2018
12 Reads

Case 34-2017. A 76-Year-Old Man with Fever, Weight Loss, and Weakness.

N Engl J Med 2017 11;377(19):1878-1886

From the Departments of Neurology (J.L.L., T.A.C.), Radiology (P.W.S.), and Pathology (M.M.A.), Harvard Medical School, the Department of Neurology, Brigham and Women's Hospital (J.L.L.), and the Departments of Neurology (T.A.C.), Radiology (P.W.S.), and Pathology (M.M.A.), Massachusetts General Hospital - all in Boston.

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http://dx.doi.org/10.1056/NEJMcpc1707557DOI Listing
November 2017
3 Reads

Similarities and differences in neuroplasticity mechanisms between brain gliomas and nonlesional epilepsy.

Epilepsia 2017 12 3;58(12):2038-2047. Epub 2017 Nov 3.

Department of Neurosurgery, Gui de Chauliac Hospital, Montpellier, France.

Objective: To analyze the conceptual and practical implications of a hodotopic approach in neurosurgery, and to compare the similarities and the differences in neuroplasticity mechanisms between low-grade gliomas and nonlesional epilepsy.

Methods: We review the recent data about the hodotopic organization of the brain connectome, alongside the organization of epileptic networks, and analyze how these two structures interact, suggesting therapeutic prospects. Then we focus on the mechanisms of neuroplasticity involved in glioma natural course and after glioma surgery. Read More

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https://www.researchgate.net/profile/Caroline_Apra/publicati
Web Search
https://onlinelibrary.wiley.com/doi/pdf/10.1111/epi.13935
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https://amedeo.com/medicine/epi/epileps.htm
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http://doi.wiley.com/10.1111/epi.13935
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http://dx.doi.org/10.1111/epi.13935DOI Listing
December 2017
43 Reads

Alcoholic liver disease confers a worse prognosis than HCV infection and non-alcoholic fatty liver disease among patients with cirrhosis: An observational study.

PLoS One 2017 27;12(10):e0186715. Epub 2017 Oct 27.

Division of Gastroenterology and Hepatology, Centre Hospitalier Universitaire Vaudois, Université de Lausanne, Lausanne, Switzerland.

Background: Cirrhosis is a heterogeneous clinical condition that includes patients at wide-ranging stages of severity. The role of the underlying liver disease on patient prognosis remains unclear.

Aim: To assess the impact of the underlying liver disease on the occurrence of hepatocellular carcinoma (HCC) and death. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0186715PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5659599PMC
November 2017
21 Reads

[The management of patients with new epileptic seizures in the early period after resection of hemispheric tumors: two case reports and a literature review].

Zh Vopr Neirokhir Im N N Burdenko 2017;81(5):96-103

Burdenko Neurosurgical Institute, Moscow, Russia.

Epileptic seizures developing for the first time after a neurosurgical intervention (de novo seizures) are a challenge for choosing an optimal treatment. The pathogenesis of these seizures is often associated with factors that become inactive in the early postoperative period. These seizures can not serve the basis for diagnosing symptomatic epilepsy and should be regarded as a brain response to surgery, and patients do not need anticonvulsant therapy that reduces the quality of life. Read More

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http://dx.doi.org/10.17116/neiro201781596-103DOI Listing
April 2018
4 Reads

Prevalence, Characteristics, and Long-Term Prognosis of Epilepsy Associated with Pediatric Brain Tumors.

World Neurosurg 2018 Jan 17;109:e594-e600. Epub 2017 Oct 17.

The Pediatric Neurosurgery Unit, Rambam Health Care Campus, Haifa, Israel. Electronic address:

Objective: We investigated the prevalence, onset, characteristics, and long-term course of epilepsy disease in children who underwent surgical intervention for diagnosed brain tumors.

Methods: We reviewed the medical records of children with diagnosed brain tumors who underwent surgery during 2004-2014 at the Hadassah Medical Center. All patients with epilepsy were invited to a clinical visit that included a neurologic examination. Read More

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http://dx.doi.org/10.1016/j.wneu.2017.10.038DOI Listing
January 2018
17 Reads

Biobibliometrics (UGDH-TP53-BRCA1) Genes Connections in the Possible Relationship Between Breast Cancer and EEG.

Adv Exp Med Biol 2017 ;987:99-107

Medical School of Ioannina, University of Ioannina, Ioannina, Greece.

In recent years there has been an increasingly amount of data stored in biomedical Databases due to the breakthroughs in biology and bioinformatics, biomedical information is growing exponentially making efficient information retrieval from scientist more and more challenging. New Scientific fields as Bioinformatics seem to be the tool needed to extract scientifically important data based on experimental results and information provided by papers and journals. In this paper we are going to implement a custom made IT system in order to find connections between genes in the breast cancer pathways such the BRCA1 with the electrical energy in the human brain with UGDH gene via the TP53 tumor gene. Read More

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http://dx.doi.org/10.1007/978-3-319-57379-3_10DOI Listing