234 results match your criteria EEG Triphasic Waves


[ANTIBIOTIC-ASSOCIATED ENCEPHALOPATHY].

Harefuah 2020 May;159(5):364-369

Department of Medicine A, Laniado Hospital, Sanz Medical Center, Netanya.

Introduction: Antibiotic-associated encephalopathy (AAE) is a relatively uncommon adverse drug event, mostly encountered in hospitalized patients undergoing intravenous antibiotic treatment. A typical case is reported and the literature is reviewed. Most antibiotic drugs have been implicated in the pathogenesis. Read More

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Generalized Periodic Discharges With Triphasic Morphology in the Setting of Aztreonam Neurotoxicity.

Clin EEG Neurosci 2020 May 13:1550059420917842. Epub 2020 May 13.

Johns Hopkins Bayview Medical Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Generalized periodic discharges with triphasic morphology (GPDs + TWm) have been reported with multiple metabolic and drug toxicities. Beta-lactam antibiotics in some cases can cause neurotoxicity with GPDs + TWm on EEG. There are no reports in the literature of aztreonam causing neurotoxicity and GPDs + TWm. Read More

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http://dx.doi.org/10.1177/1550059420917842DOI Listing

Clinical characteristics and epilepsy in genomic imprinting disorders: Angelman syndrome and Prader-Willi syndrome.

Ci Ji Yi Xue Za Zhi 2019 Apr-Jun;32(2):137-144. Epub 2019 Oct 31.

Department of Pediatrics, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei, Taiwan.

Angelman syndrome (AS) and Prader-Willi syndrome (PWS) are considered sister imprinting disorders. Although both AS and PWS congenital neurodevelopmental disorders have chromosome 15q11.3-q13 dysfunction, their molecular mechanisms differ owing to genomic imprinting, which results in different parent-of-the-origin gene expressions. Read More

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http://dx.doi.org/10.4103/tcmj.tcmj_103_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7137370PMC
October 2019

Clinical and Radiological Correlates of Different Electroencephalographic Pattern in Hospitalized Patients.

Authors:
Saima Nazish

Clin EEG Neurosci 2020 Mar 6:1550059420910559. Epub 2020 Mar 6.

Department of Neurology, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia.

. The present study aimed to determine the clinical and radiological correlates of different electroencephalographic (EEG) patterns in hospitalized patients. . Read More

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http://dx.doi.org/10.1177/1550059420910559DOI Listing

A novel neural computational model of generalized periodic discharges in acute hepatic encephalopathy.

J Comput Neurosci 2019 12 11;47(2-3):109-124. Epub 2019 Sep 11.

The Department of Neurology, Massachusetts General Hospital, Boston, MA, USA.

Acute hepatic encephalopathy (AHE) due to acute liver failure is a common form of delirium, a state of confusion, impaired attention, and decreased arousal. The electroencephalogram (EEG) in AHE often exhibits a striking abnormal pattern of brain activity, which epileptiform discharges repeat in a regular repeating pattern. This pattern is known as generalized periodic discharges, or triphasic-waves (TPWs). Read More

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http://link.springer.com/10.1007/s10827-019-00727-3
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http://dx.doi.org/10.1007/s10827-019-00727-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6881550PMC
December 2019
3 Reads

Clinical EEG slowing correlates with delirium severity and predicts poor clinical outcomes.

Neurology 2019 09 29;93(13):e1260-e1271. Epub 2019 Aug 29.

From the Department of Neurology (E.Y.K., A.N., W.W., A.R.S., S.L.R., G.G., D.G., M.B.W.) and Clinical Data Animation Center (M.B.W.), Massachusetts General Hospital, Boston.

Objective: To determine which findings on routine clinical EEGs correlate with delirium severity across various presentations and to determine whether EEG findings independently predict important clinical outcomes.

Methods: We prospectively studied a cohort of nonintubated inpatients undergoing EEG for evaluation of altered mental status. Patients were assessed for delirium within 1 hour of EEG with the 3-Minute Diagnostic Interview for Confusion Assessment Method (3D-CAM) and 3D-CAM severity score. Read More

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http://www.neurology.org/lookup/doi/10.1212/WNL.000000000000
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http://dx.doi.org/10.1212/WNL.0000000000008164DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7011865PMC
September 2019
6 Reads

Clinical neurophysiology of altered states of consciousness: Encephalopathy and coma.

Handb Clin Neurol 2019 ;161:73-88

Department of Neurology, Johns Hopkins Hospital, Baltimore, MD, United States. Electronic address:

The neurophysiologist will commonly encounter patients with encephalopathy/delirium (altered consciousness with impaired cognition, usually with sleep-wake cycle alteration and lethargy) or coma (an eyes-closed state of unresponsiveness) in the hospital setting. Assessing the background frequency of the EEG, as well as the presence or absence of other features (reactivity, periodic discharges such as triphasic waves), can provide insight into the patient's underlying condition and in some cases may provide prognostic information. The literature of postanoxic arrest EEG patterns continues to expand. Read More

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http://dx.doi.org/10.1016/B978-0-444-64142-7.00041-2DOI Listing
January 2020
6 Reads

Cephalosporin-related neurotoxicity: Metabolic encephalopathy or non-convulsive status epilepticus?

J Clin Neurosci 2019 Sep 11;67:163-166. Epub 2019 Jun 11.

Royal Perth Hospital, Department of Neurology, Perth, Western Australia, Australia; Western Australian Adult Epilepsy Service, Perth, Western Australia, Australia; University of Western Australia, Faculty of Medicine, Perth, Western Australia, Australia.

Metabolic encephalopathy and Non-Convulsive Status Epilepticus (NCSE) have been reported with cephalosporin use, particularly cefepime. We aimed to analyze the clinical and EEG findings in patients with cephalosporin-related neurotoxicity (CRN) at our hospital identified via the hospital EEG database, and to critically review CRN case reports in the literature. A Medline search was performed to identify CRN cases where a representative sample of EEG was provided. Read More

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http://dx.doi.org/10.1016/j.jocn.2019.05.035DOI Listing
September 2019
7 Reads

Young-onset sporadic Creutzfeldt-Jakob disease with atypical phenotypic features: a case report.

J Med Case Rep 2019 May 29;13(1):163. Epub 2019 May 29.

Department of Neurology, Bangur Institute of Neurosciences, IPGMER and SSKM Hospital, Kolkata, West Bengal, 700025, India.

Background: Sporadic Creutzfeldt-Jakob disease, with a mean survival of 6 months, is duly considered among the most fatal neurological disorders. Rapidly progressive dementia with multi-axial involvement of the nervous system is the known presentation. Although, the peak age at onset is between sixth and eighth decades, cases of young-onset sporadic Creutzfeldt-Jakob disease have also been reported in the literature. Read More

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http://dx.doi.org/10.1186/s13256-019-2089-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6540443PMC
May 2019
25 Reads

Clinical features and genetic characteristics of two Chinese pedigrees with fatal family insomnia.

Prion 2019 01;13(1):116-123

b National Clinical Research Center for Geriatric Disorders , Changsha , Hunan , China.

: Fatal familial insomnia (FFI) is a rare autosomal-dominant inherited prion disease characterized clinically by severe sleep disorder, motor signs, dysautonomia and abnormal behaviour. FFI is caused by a missense mutation at codon 178 of the prion protein gene (PRNP). Our study is aimed to explore typical clinical and genetic features of two Chinese pedigrees with FFI and review the related literatures. Read More

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http://dx.doi.org/10.1080/19336896.2019.1617027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6629183PMC
January 2019
9 Reads
2.241 Impact Factor

Atypical Interictal Epileptiform Discharges in Electroencephalography.

J Epilepsy Res 2018 Dec 31;8(2):55-60. Epub 2018 Dec 31.

King Khalid Hospital (KKH), Hail, Saudi Arabia.

Background And Purpose: A great deal of attention has been focused on "typical" interictal epileptiform discharges (IEDs) in the electroencephalography (EEG) literature. However, there is a paucity of data on "atypical" IEDs, namely, positive sharp waves (PSWs), focal triphasic sharp waves and spikes (FTSWs), sharp slow waves (SSWs), bifid spikes, and "notched" delta. In this present study, we sought to address the pathophysiology, characteristics, and diagnostic significance of "atypical" IEDs in clinical neuroscience. Read More

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http://j-epilepsy.org/journal/view.php?doi=10.14581/jer.1800
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http://dx.doi.org/10.14581/jer.18009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374539PMC
December 2018
13 Reads

Encephalopathy Induced by High Plasma and Cerebrospinal Fluid Ceftriaxone Concentrations in a Hemodialysis Patient.

Intern Med 2019 Jun 25;58(12):1775-1779. Epub 2019 Feb 25.

Department of Nephrology, Tokyo Medical and Dental University, Japan.

Encephalopathy is a rare side effect of cephalosporin treatment. We herein present a case of encephalopathy induced by ceftriaxone, a third-generation cephalosporin, in a patient with renal failure. An 86-year-old woman on maintenance hemodialysis received ceftriaxone for Helicobacter cinaedi bacteremia. Read More

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http://dx.doi.org/10.2169/internalmedicine.1785-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6630125PMC
June 2019
2 Reads
0.967 Impact Factor

Clinical, Electroencephalographic Features and Prognostic Factors of Cefepime-Induced Neurotoxicity: A Retrospective Study.

Neurocrit Care 2019 10;31(2):329-337

Section of Epilepsy, Department of Neurology, Chang Gung Memorial Hospital at Linkou Medical Center and Chang Gung University College of Medicine, 5 Fuxing St., Guishan Dist., Taoyuan, 333, Taiwan.

Background: The incidence of cefepime-induced neurotoxicity (CIN) has been previously underestimated, and there have only been sporadic reports from critical neurological settings. The present study aimed to investigate the potential factors associated with disease development, electroencephalography (EEG) sub-classification, and outcome measures.

Methods: The 10-year medical records of patients who underwent EEG between 2007 and 2016 at a tertiary medical center in Taiwan, and developed encephalopathy after cefepime therapy were retrospectively reviewed. Read More

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http://dx.doi.org/10.1007/s12028-019-00682-yDOI Listing
October 2019
7 Reads
2.440 Impact Factor

Similarities and differences between the interictal epileptiform discharges of green-spikes and red-spikes zones of human neocortex.

Authors:
Ruggero Serafini

Clin Neurophysiol 2019 03 19;130(3):396-405. Epub 2019 Jan 19.

Department of Neurology, University of Utah, Clinical Neuroscience Center, George E. Wahlen VA Medical Center, Salt Lake City, UT, USA. Electronic address:

Objective: This study looks for differences in the waveforms of interictal epileptiform discharges (IEDs) between cortices expressing only isolated discharges (green-spikes zones) vs those manifesting seizures (red-spikes zones): these can help to understand ictogenesis mechanisms and improve clinical decision in surgical epilepsy. Typical IEDs are triphasic, exhibiting in sequence: a negative-sharp-wave, a positive-baseline-shift and a negative-slow-wave. Negative-slow-waves are thought to reflect neurophysiological inhibition: their features at a focus' edge may reflect peripheral inhibition, a mechanism characterized in experimental models, curbing seizures' spread. Read More

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http://dx.doi.org/10.1016/j.clinph.2018.12.011DOI Listing

Baclofen Neurotoxicity: A Metabolic Encephalopathy Susceptible to Exacerbation by Benzodiazepine Therapy.

J Clin Neurophysiol 2019 May;36(3):209-212

Department of Neurology, Royal Perth Hospital, Perth, Australia.

Purpose: Baclofen has been reported to cause both a metabolic encephalopathy and nonconvulsive status epilepticus. Baclofen is typically used in the management of muscle spasticity but is being increasingly used to manage alcohol withdrawal and opiate dependency. Given the increasing use of baclofen we describe the clinical and electrographical features of baclofen neurotoxicity seen at our institution. Read More

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http://dx.doi.org/10.1097/WNP.0000000000000565DOI Listing
May 2019
15 Reads

Hepatic encephalopathy revisited: Beyond the triphasic waves.

Clin Neurophysiol 2019 03 20;130(3):408-409. Epub 2018 Dec 20.

Department of Neurology, Utano National Hospital, National Hospital Organization, Kyoto, Japan.

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http://dx.doi.org/10.1016/j.clinph.2018.12.003DOI Listing
March 2019
2 Reads

A Mean Field Model of Acute Hepatic Encephalopathy.

Conf Proc IEEE Eng Med Biol Soc 2018 07;2018:2366-2369

Acute hepatic encephalopathy (AHE) is a common form of delirium, a state of confusion, impaired attention, and decreased arousal due to acute liver failure. However, the neurophysiological mechanisms underlying AHE are poorly understood. In order to develop hypotheses for mechanisms of AHE, our work builds on an existing neural mean field model for similar EEG patterns in cerebral anoxia, the bursting Liley model. Read More

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http://dx.doi.org/10.1109/EMBC.2018.8512786DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7088433PMC
July 2018
36 Reads

Triphasic Waves and Encephalopathy in the Setting of Pregabalin Toxicity.

J Clin Neurophysiol 2018 Nov;35(6):515-517

Department of Neurology, Johns Hopkins Bayview Medical Center, Baltimore, Maryland, U.S.A.

EEG triphasic waves are usually seen in the setting of metabolic encephalopathies, but may also occur secondary to medication toxicity. There are few reports of medications causing continuous triphasic waves, and only rare reports in the literature show an association between these discharges and pregabalin toxicity. Here, we describe triphasic waves in a patient with underlying white matter lesions, as well as pregabalin toxicity, secondary to renal insufficiency. Read More

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http://dx.doi.org/10.1097/WNP.0000000000000511DOI Listing
November 2018
38 Reads

[Clinical, neuroimaging and genetic features of two Chinese families with fatal familial insomnia].

Zhonghua Yi Xue Za Zhi 2018 Aug;98(31):2501-2504

Department of Neurology, the Navy General Hospital, Beijing 100048, China.

To examine clinical, neuroimaging and genetic features of two Chinese families with fatal familial insomnia (FFI). The clinical data, including case history, physical examination, biochemical analysis of blood and neuroimaging of two pedigrees with FFI who admitted to the Navy General Hospital in 2014 and 2017 were collected. The D178N prion protein (PRNP) mutation were determined by DNA sequencing among the proband and family members. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0376-2491.2018.31.010DOI Listing
August 2018
5 Reads

Baclofen-induced encephalopathy in overdose - Modeling of the electroencephalographic effect/concentration relationships and contribution of tolerance in the rat.

Prog Neuropsychopharmacol Biol Psychiatry 2018 08 18;86:131-139. Epub 2018 May 18.

Inserm UMRS-1144, Paris-Descartes University, Paris, France.

Baclofen, a γ-amino-butyric acid type-B receptor agonist with exponentially increased use at high-dose to facilitate abstinence in chronic alcoholics, is responsible for increasing poisonings. Baclofen overdose may induce severe encephalopathy and electroencephalographic (EEG) abnormalities. Whether prior prolonged baclofen treatment may influence the severity of baclofen-induced encephalopathy in overdose has not been established. Read More

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http://dx.doi.org/10.1016/j.pnpbp.2018.05.016DOI Listing
August 2018
24 Reads

Low mood, visual hallucinations, and falls - heralding the onset of rapidly progressive probable sporadic Creutzfeldt-Jakob disease in a 73-year old: a case report.

J Med Case Rep 2018 May 8;12(1):128. Epub 2018 May 8.

Chelsea and Westminster Hospitals NHS Foundation Trust, West Middlesex University Hospital, Twickenham Rd, Isleworth, TW7 6AF, UK.

Background: Creutzfeldt-Jakob disease is a rare and rapidly fatal neurodegenerative disease. Since clinicians may see only very few cases during their professional career, it is important to be familiar with the clinical presentation and progression, to perform appropriate investigations, and allow for quick diagnosis.

Case Presentation: A 73-year-old British Caucasian woman presented with acute confusion of 2 weeks' duration on a background of low mood following a recent bereavement. Read More

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http://dx.doi.org/10.1186/s13256-018-1649-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5938807PMC
May 2018
15 Reads

The Relationship of Triphasic Waves with Intracranial Pressure as a Possible Prognostic Marker in Traumatic Brain Injury.

Case Rep Neurol Med 2017 28;2017:4742026. Epub 2017 Nov 28.

Department of Neurology, University of Missouri, 5 Hospital Drive, CE 540, Columbia, MO 65211, USA.

Background: Continuous electroencephalography (CEEG) monitoring is used for detection of convulsive and nonconvulsive seizures and assessing the degree of encephalopathy in critically ill patients. A commonly seen encephalopathic pattern on CEEG is generalized periodic discharges with triphasic wave (TW) morphology. The underlying role and prognostic significance of TW in relationship to intracranial pressure (ICP) remain unknown. Read More

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http://dx.doi.org/10.1155/2017/4742026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5727623PMC
November 2017
13 Reads

Cefepime induced neurotoxicity: A case series and review of the literature.

eNeurologicalSci 2017 Sep 4;8:40-43. Epub 2017 Aug 4.

Department of Neurology, Boston University School of Medicine, Boston, MA, United States.

Cefepime is a fourth generation cephalosporin which is bactericidal for broad spectrum of organisms. This is a case-series of three patients who presented to our hospital with confusion secondary to cefepime use to treat urinary tract infection (UTI) and health care associated pneumonia (HCAP), after excluding other common etiologies of altered mental status (AMS). Of these three patients, one had progressive expressive aphasia and the other two demonstrated asynchronous myoclonic activity of the limbs. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S24056502173002
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http://dx.doi.org/10.1016/j.ensci.2017.08.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5730896PMC
September 2017
16 Reads

Generalized Periodic Discharges With and Without Triphasic Morphology.

J Clin Neurophysiol 2018 Mar;35(2):144-150

Neurological Institute, University Hospitals Cleveland Medical Center, Case Western Reserve University, Cleveland, Ohio, U.S.A.

Purpose: Generalized periodic discharges (GPDs) with a triphasic morphology have been associated with nonepileptic encephalopathies. We conducted the study to assess the reliability in which electroencephalographers can differentiate triphasic from nontriphasic periodic discharges and to evaluate for the presence of electroencephalogram and clinical characteristics that are associated with a higher risk of seizures.

Methods: We studied prospectively 92 patients between May 2016 and February 2017. Read More

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http://Insights.ovid.com/crossref?an=00004691-201803000-0001
Publisher Site
http://dx.doi.org/10.1097/WNP.0000000000000441DOI Listing
March 2018
17 Reads
1.600 Impact Factor

[Portal-systemic encephalopathy with bilateral thalamic and internal capsule lesions using diffusion-weighted MRI in a super-aged patient].

Rinsho Shinkeigaku 2017 Dec 28;57(12):759-763. Epub 2017 Nov 28.

Department of Neurology, Nanpuh Hospital.

We describe the case of a 90-year-old woman who was hospitalized in July 2016 and subsequently experienced a sudden decline in consciousness level resulting in a state of deep coma. Involuntary movements were not observed, and bilateral Babinski signs were inconclusive. Diffusion-weighted MRI (DWI) of the brain showed bilateral hyperintensity in the thalamus and internal capsule, laboratory testing detected high levels of plasma ammonia, and an electroencephalogram showed delta waves and triphasic waves predominantly in the frontal lobe. Read More

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http://dx.doi.org/10.5692/clinicalneurol.cn-001068DOI Listing
December 2017
22 Reads

Cefepime-induced neurotoxicity: a systematic review.

Crit Care 2017 Nov 14;21(1):276. Epub 2017 Nov 14.

Department of Pharmacy and Critical Care, Maine Medical Center, 22 Bramhall St, Portland, ME, 04102, USA.

Background: Cefepime is a widely used antibiotic with neurotoxicity attributed to its ability to cross the blood-brain barrier and exhibit concentration-dependent ϒ-aminobutyric acid (GABA) antagonism. Neurotoxic symptoms include depressed consciousness, encephalopathy, aphasia, myoclonus, seizures, and coma. Data suggest that up to 15% of ICU patients treated with cefepime may experience these adverse effects. Read More

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http://dx.doi.org/10.1186/s13054-017-1856-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5686900PMC
November 2017
63 Reads

Pregabalin Toxicity Manifesting as Reversible Encephalopathy With Continuous Triphasic Waves in Electroencephalogram.

Clin Neuropharmacol 2017 Sep/Oct;40(5):226-228

*Department of Neurology, and †Department of Nephrology, Narayana Health City, Bangalore, India.

A 74-year-old man with peripheral neuropathy due to diabetes presented with deliberate ingestion of 450 mg of pregabalin (PBG) over a period of 8 hours followed by altered mental status. A bedside electroencephalogram was performed to rule out nonconvulsive status epilepticus, which showed continuous triphasic waves (TWs) with slow background activity. He recovered after 48 hours of stopping PBG, and his repeat electroencephalogram after 72 hours did not show any TWs. Read More

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http://dx.doi.org/10.1097/WNF.0000000000000245DOI Listing
May 2018
5 Reads

Outcomes of patients with altered level of consciousness and abnormal electroencephalogram: A retrospective cohort study.

PLoS One 2017 8;12(9):e0184050. Epub 2017 Sep 8.

Department of Clinical Neurophysiology, Hospital Israelita Albert Einstein, São Paulo, Brazil.

Introduction: Nonconvulsive seizures (NCS) are frequent in hospitalized patients and may further aggravate injury in the already damaged brain, potentially worsening outcomes in encephalopathic patients. Therefore, both early seizure recognition and treatment have been advocated to prevent further neurological damage.

Objective: Evaluate the main EEG patterns seen in patients with impaired consciousness and address the effect of treatment with antiepileptic drugs (AEDs), continuous intravenous anesthetic drugs (IVADs), or the combination of both, on outcomes. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0184050PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5590878PMC
November 2017
29 Reads

Electroencephalographic findings in patients with circumscribed thalamic lesions.

Epilepsy Res 2017 09 15;135:115-122. Epub 2017 Jun 15.

Department of Neurology, University Hospital Ulm, Oberer Eselsberg 45, 89081 Ulm, Germany; Epilepsy Center Bethel, Mara Hospital, Maraweg 21, 33617 Bielefeld, Germany. Electronic address:

Introduction: Thalamo-cortical networks have mainly been studied in the generation of idiopathic (genetic) epilepsies. The purpose of this study was to analyze EEG patterns and the occurrence of focal (symptomatic) epileptic seizures in patients with acquired circumscribed thalamic lesions.

Patients And Methods: Among 596 patients with thalamic lesions, we identified 47 patients in whom circumscribed thalamic lesions were detected by MRI and who underwent an EEG examination at the same stay at hospital. Read More

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http://dx.doi.org/10.1016/j.eplepsyres.2017.06.009DOI Listing
September 2017
29 Reads

Diagnostic Yield of Routine Electroencephalography With Concurrent Video Recording in Detecting Interictal Epileptiform Discharges in Relation to Reasons for Request: A Prospective Study of 1,080 Video-Electroencephalograms.

J Clin Neurophysiol 2017 Sep;34(5):434-437

Department of Neurosciences, Hospital Universitari Germans Trias i Pujol, Badalona, Spain.

Purpose: The aim of this study was to prospectively analyze the sensitivity and specificity of routine electroencephalography with concurrent video recording (vEEG) in relation to the reasons for requesting the test and to investigate when routine vEEG should be requested.

Methods: We prospectively analyzed 1,080 consecutive vEEGs performed between April 2015 and April 2016. The requests for vEEG were classified as requests with a low suspicion of epilepsy (syncope, confusion or delirium, suspicion of psychogenic nonepileptic seizures, and paroxysmal focal neurological deficit) or requests with a high suspicion of epilepsy (first clinical seizure, suspected status epilepticus, follow-up study of a patient with epilepsy, and acute symptomatic seizures). Read More

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http://dx.doi.org/10.1097/WNP.0000000000000390DOI Listing
September 2017
34 Reads

The relationship between epileptiform discharges and background activity in the visual analysis of electroencephalographic examinations in dogs with seizures of different etiologies.

Vet J 2017 Apr 16;222:41-51. Epub 2017 Mar 16.

Department of Neurology, Wrocław Medical University, ul. Borowska 213, 50-556 Wrocław, Poland.

Electroencephalographic (EEG) recordings in 125 outpatient dogs with various epileptiform encephalopathies were acquired under medetomidine sedation using subdermal wire electrodes. The features of canine EEG (background activity [BGA] and epileptiform discharges [EDs]) were assessed, described and compared. The dogs included neurologically healthy controls (N, n = 19), dogs with portosystemic shunt (PSS, n = 9), dogs with intracranial pathologies (IP, n = 27) and dogs with idiopathic epilepsy (IE, n = 70). Read More

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http://dx.doi.org/10.1016/j.tvjl.2017.03.003DOI Listing
April 2017
24 Reads

Minimal EEG montage with high yield for the detection of status epilepticus in the setting of postanoxic brain damage.

Acta Neurol Belg 2017 Mar 1;117(1):145-152. Epub 2016 Jul 1.

Department of Neurology, University Hospitals Leuven, Herestraat 49, 3000, Leuven, Belgium.

For the diagnosis of electrographic seizures or status epilepticus, we reduced the number of EEG-electrodes to make urgent EEG monitoring more feasible. Unlike the current existing research, with mixed results, we studied a specific population with postanoxic brain damage, expecting a higher yield of detection of ictal EEG patterns. In a population treated with therapeutic hypothermia post-cardiac arrest, the initial EEGs were reformatted in a longitudinal, a hairline and an 8-lead montage, and independently reviewed by two investigators. Read More

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http://dx.doi.org/10.1007/s13760-016-0663-9DOI Listing
March 2017
19 Reads

Associated Factors and Prognostic Implications of Stimulus-Induced Rhythmic, Periodic, or Ictal Discharges.

JAMA Neurol 2016 May;73(5):585-90

Department of Neurology, Mayo Clinic, Rochester, Minnesota.

Importance: The implications of stimulus-induced rhythmic, periodic, or ictal discharges (SIRPIDs) sometimes found on prolonged electroencephalographic (EEG) recordings are uncertain.

Objective: To evaluate the incidence of SIRPIDs and their clinical implications in critically ill patients.

Design, Setting, And Participants: A multicenter, international retrospective study was performed from October 1, 2012, through September 30, 2014, of consecutive adult patients hospitalized in intensive care units with alteration of consciousness who underwent EEG recordings at 3 separate centers. Read More

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http://dx.doi.org/10.1001/jamaneurol.2016.0006DOI Listing
May 2016
30 Reads

Syndrome of transient headache and neurological deficits with cerebrospinal fluid lymphocytosis (HaNDL): A case report with serial electroencephalography (EEG) recordings.. Is there an association with human herpes virus type 7 (HHV-7) infection?

Cephalalgia 2016 Nov 20;36(13):1296-1301. Epub 2016 Jul 20.

1 Department of Neurology and Clinical Neurophysiology, Canisius Wilhelmina Hospital, The Netherlands.

Introduction The syndrome of transient headache and neurological deficits with cerebrospinal fluid lymphocytosis (HaNDL) is a diagnosis made by exclusion. In the literature, different etiological explanations are proposed for HaNDL, including an immune-mediated reaction after a viral infection. Case description We present a case of a 23-year-old woman with several episodes of transient headache, neurological deficits and cerebrospinal fluid lymphocytosis. Read More

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http://dx.doi.org/10.1177/0333102415618616DOI Listing
November 2016
81 Reads

Affair With Triphasic Waves-Their Striking Presence, Mysterious Significance, and Cryptic Origins: What are They?

J Clin Neurophysiol 2015 Oct;32(5):401-5

*Department of Neurology, Johns Hopkins Bayview Medical Center, Baltimore, Maryland, U.S.A.; †Clinic for Intensive Care Medicine, University Hospital Base, Basel, Switzerland; and ‡Department of Neurology, Division of Clinical Neurophysiology, University Hospital Basel, Basel, Switzerland.

Triphasic waves, which have been recorded in the EEG of encephalopathy for more than 50 years, remain clearly identifiable but historically purportedly of uncertain significance. Initially described with liver failure and high serum ammonias, they came to be reported in an ever-expanding list of metabolic, toxic, and structural conditions. Often a dynamic finding (in which the occurrence of triphasic waves might increase or decrease with stimulation or arousal of the patient during EEG), there has been increasing insight into their correlation with multiple concurrent conditions, including subcortical white-matter disease, infections and metabolic disturbances, and their prognostic significance. Read More

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http://dx.doi.org/10.1097/WNP.0000000000000151DOI Listing
October 2015
82 Reads
6 Citations
1.600 Impact Factor

Stimulus-induced reflex epileptic spasms in 5p- syndrome.

Brain Dev 2016 Feb 18;38(2):261-5. Epub 2015 Aug 18.

Division of Child Neurology, Institute of Neurological Sciences, Faculty of Medicine, Tottori University, Yonago, Tottori, Japan.

Here we describe two patients with 5p- syndrome who suffered from epilepsy characterised by stimulus-induced epileptic spasms manifesting as head nodding. In patient 1, a series of spasms were exclusively triggered by eating, and were associated with diffuse high-voltage slow waves on ictal EEG, particularly presenting as a positive slow potential at the left mid-temporal area. Clusters of sharp waves with negative polarity emerged in the same area during the inter-spasm periods during eating. Read More

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http://dx.doi.org/10.1016/j.braindev.2015.08.002DOI Listing
February 2016
25 Reads

Generalized periodic discharges and 'triphasic waves': A blinded evaluation of inter-rater agreement and clinical significance.

Clin Neurophysiol 2016 Feb 7;127(2):1073-1080. Epub 2015 Aug 7.

Emory University School of Medicine, Department of Neurology, 1365 Clifton Rd, Atlanta, GA 30322, USA.

Objectives: Generalized periodic discharges (GPDs) are associated with nonconvulsive seizures. Triphasic waves (TWs), a subtype of GPDs, have been described in relation to metabolic encephalopathy and not felt to be associated with seizures. We sought to establish the consistency of use of this descriptive term and its association with seizures. Read More

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http://dx.doi.org/10.1016/j.clinph.2015.07.018DOI Listing
February 2016
54 Reads

Ictal and interictal EEG patterns in patients with nonconvulsive and subtle convulsive status epilepticus.

Epilepsy Behav 2015 Aug 14;49:263-7. Epub 2015 Jun 14.

National Neuroscience Institute and Singapore General Hospital, Singapore; Dukes-NUS Medical School, Singapore. Electronic address:

Background: Electroencephalography findings in nonconvulsive or subtle convulsive status epilepticus (NCSE and SCSE, respectively) can be heterogenous. We aimed to study the different patterns on EEG in our cohort of patients.

Objective: Our objective was to study ictal and interictal EEG patterns in patients with NCSE and SCSE. Read More

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http://dx.doi.org/10.1016/j.yebeh.2015.05.011DOI Listing
August 2015
38 Reads

Response Rates to Anticonvulsant Trials in Patients with Triphasic-Wave EEG Patterns of Uncertain Significance.

Neurocrit Care 2016 Apr;24(2):233-9

Department of Neurology, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, WACC 735, Boston, MA, 02114, USA.

Background: Generalized triphasic waves (TPWs) occur in both metabolic encephalopathies and non-convulsive status epilepticus (NCSE). Empiric trials of benzodiazepines (BZDs) or non-sedating AED (NSAEDs) are commonly used to differentiate the two, but the utility of such trials is debated. The goal of this study was to assess response rates of such trials and investigate whether metabolic profile differences affect the likelihood of a response. Read More

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http://dx.doi.org/10.1007/s12028-015-0151-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4870012PMC
April 2016
13 Reads

Atypical sporadic CJD-MM phenotype with white matter kuru plaques associated with intranuclear inclusion body and argyrophilic grain disease.

Neuropathology 2015 Aug 18;35(4):336-42. Epub 2015 Mar 18.

Institute of Neurology and Austrian Reference Center for Human Prion Diseases, Medical University of Vienna, Vienna, Austria.

We describe an atypical neuropathological phenotype of sporadic Creutzfeldt-Jakob disease in a 76-year-old man. The clinical symptoms were characterized by progressive dementia, gait ataxia, rigidity and urinary incontinence. The disease duration was 6 weeks. Read More

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http://doi.wiley.com/10.1111/neup.12192
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http://dx.doi.org/10.1111/neup.12192DOI Listing
August 2015
20 Reads

Nonconvulsive status epilepticus and Creutzfeldt-Jakob-like EEG changes in a case of lithium toxicity.

Authors:
B K Madhusudhan

Epilepsy Behav Case Rep 2014 28;2:203-5. Epub 2014 Nov 28.

Department of Neurology, M.S. Ramaiah Medical College, New BEL Road, Mathikere, Bangalore -560054, India.

We report a case of a 63-year-old lady with bipolar affective disorder on lithium who was brought to our emergency center in a comatose state. Neurologically, the patient was comatose and had generalized hypotonia and hyporeflexia. Lithium toxicity was considered. Read More

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http://dx.doi.org/10.1016/j.ebcr.2014.08.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4308059PMC
February 2015
13 Reads

Correlates of a single cortical action potential in the epidural EEG.

Neuroimage 2015 Apr 30;109:357-67. Epub 2014 Dec 30.

Neurophysics Group, Department of Neurology, Campus Benjamin Franklin, Charité-Universitätsmedizin Berlin, 12200 Berlin, Germany; Bernstein Center for Computational Neuroscience Berlin, 10115 Berlin, Germany; Bernstein Focus Neurotechnology Berlin, 10587 Berlin, Germany.

To identify the correlates of a single cortical action potential in surface EEG, we recorded simultaneously epidural EEG and single-unit activity in the primary somatosensory cortex of awake macaque monkeys. By averaging over EEG segments coincident with more than hundred thousand single spikes, we found short-lived (≈ 0.5 ms) triphasic EEG deflections dominated by high-frequency components >800 Hz. Read More

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http://dx.doi.org/10.1016/j.neuroimage.2014.12.057DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4349634PMC
April 2015
11 Reads

A study of clinical profile, radiological and electroencephalographic characteristics of suspected Creutzfeldt-Jakob disease in a tertiary care centre in South India.

J Neurosci Rural Pract 2015 Jan;6(1):39-50

Department of Neurology, MS Ramaiah Medical College and Hospital, Bangalore, Karnataka, India.

Introduction: Creutzfeldt-Jakob disease (CJD) is a progressive, fatal, neurodegenerative disease classified under transmissible spongiform encephalopathies (TSE) or prion diseases. It is characterized by long asymptomatic period followed by rapid clinical deterioration leading to the death within months. The disease is still under-reported in India. Read More

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http://search.proquest.com/openview/6baa217449d5bd798bad7e80
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http://www.ruralneuropractice.com/text.asp?2015/6/1/39/14318
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http://dx.doi.org/10.4103/0976-3147.143189DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4244786PMC
January 2015
39 Reads

Clinical neurophysiological assessment of sepsis-associated brain dysfunction: a systematic review.

Crit Care 2014 Dec 8;18(6):674. Epub 2014 Dec 8.

Department of Intensive Care, Erasme University Hospital, Université Libre de Bruxelles, Route de Lennik 808, 1070, Brussels, Belgium.

Introduction: Several studies have reported the presence of electroencephalography (EEG) abnormalities or altered evoked potentials (EPs) during sepsis. However, the role of these tests in the diagnosis and prognostic assessment of sepsis-associated encephalopathy remains unclear.

Methods: We performed a systematic search for studies evaluating EEG and/or EPs in adult (≥ 18 years) patients with sepsis-associated encephalopathy. Read More

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http://dx.doi.org/10.1186/s13054-014-0674-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4277650PMC
December 2014
14 Reads

Electroencephalographic changes in sporadic Creutzfeldt-Jakob disease and correlation with clinical stages: a retrospective analysis.

J Clin Neurophysiol 2014 Dec;31(6):586-93

*Department of Neuroscience, Monash Medical Centre, Clayton, Victoria, Australia; and †Department of Medicine, Monash University, Melbourne, Victoria, Australia.

Purpose: To analyze clinical features and EEG changes in patients with sporadic Creutzfeldt-Jakob disease and study the association between different EEG patterns and clinical stages.

Methods: We retrospectively analyzed the clinical features and EEG patterns of 3 patients with clinical stage II and 10 patients with stage III sporadic Creutzfeldt-Jakob disease (EEG n = 17). Chi-square test was used to study the association between EEG features and disease stages. Read More

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http://dx.doi.org/10.1097/WNP.0000000000000097DOI Listing
December 2014
18 Reads

Significance of triphasic waves in acute encephalopathy.

Authors:
N K Sethi

Eur J Neurol 2014 Nov;21(11):e93

Department of Neurology, New York Presbyterian Hospital, Weill Cornell Medical Center, New York, NY, USA.

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http://dx.doi.org/10.1111/ene.12493DOI Listing
November 2014
14 Reads

Focal triphasic sharp waves and spikes in the electroencephalogram.

Neurol Sci 2015 Feb 26;36(2):221-6. Epub 2014 Aug 26.

Center for Neurology, Fairfax, VA, USA,

There is a plethora of data in the EEG literature on the characteristics of the most prominent component of interictal epileptiform discharges (IED), namely the negative (fast) phase. Surprisingly, however, little attention has been drawn to the after-coming slow wave (ASW), and its pathological as well as clinical significance. In this paper, we will address the significance of prominent (high amplitude) ASW, giving rise to a triphasic morphology of the IED (focal triphasic sharp waves and spikes—FTSW). Read More

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http://www.internationalbrain.org/media/files/files/e799c5b8
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http://link.springer.com/content/pdf/10.1007/s10072-014-1923
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http://link.springer.com/10.1007/s10072-014-1923-1
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http://dx.doi.org/10.1007/s10072-014-1923-1DOI Listing
February 2015
75 Reads
1 Citation
1.500 Impact Factor

Interrater agreement for Critical Care EEG Terminology.

Epilepsia 2014 Sep 2;55(9):1366-73. Epub 2014 Jun 2.

Department of Neurology, Comprehensive Epilepsy Center, Yale University School of Medicine, New Haven, Connecticut, U.S.A.

Objective: The interpretation of critical care electroencephalography (EEG) studies is challenging because of the presence of many periodic and rhythmic patterns of uncertain clinical significance. Defining the clinical significance of these patterns requires standardized terminology with high interrater agreement (IRA). We sought to evaluate IRA for the final, published American Clinical Neurophysiology Society (ACNS)-approved version of the critical care EEG terminology (2012 version). Read More

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http://dx.doi.org/10.1111/epi.12653DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4879939PMC
September 2014
46 Reads

Application of subhairline EEG montage in intensive care unit: comparison with full montage.

J Clin Neurophysiol 2014 Jun;31(3):181-6

*GE Healthcare Finland Oy, Helsinki, Finland; and Departments of †Anesthesia and Perioperative Medicine, ‡Program in Critical Care, and §Clinical Neurological Science, of Western Ontario, London, Ontario, Canada.

Purpose: Problems with the availability of standard EEG monitoring in the intensive care unit have led to the use of recordings that have limited spatial coverage. We studied the performance of limited coverage EEG compared with more traditional full-montage EEG.

Methods: Continuous EEG recordings were performed on 170 patients using the full-montage 10-20 placement of electrodes as a reference recording and an abbreviated montage of electrodes applied below the hairline (subhairline). Read More

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http://pdfs.journals.lww.com/clinicalneurophys/2014/06000/Ap
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http://dx.doi.org/10.1097/WNP.0000000000000049DOI Listing
June 2014
40 Reads