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Ophthalmology 2019 Feb 15. Epub 2019 Feb 15.

Casey Eye Institute, Oregon Health and Science University, Portland, OR, United States.

Purpose: To compare corneal higher-order aberrations (HOA) following ultrathin Descemet stripping automated endothelial keratoplasty (UT-DSAEK) and Descemet membrane endothelial keratoplasty (DMEK).

Design: Patient and outcome-masked, randomized controlled clinical trial.

Participants: Patients with damaged or diseased endothelium from Fuchs endothelial dystrophy or pseudophakic bullous keratopathy who were considered good candidates for DMEK or UT-DSAEK. Read More

Cornea 2019 Feb 7. Epub 2019 Feb 7.

Department of Ophthalmology, University Hospitals Leuven, Leuven, Belgium.

Purpose: To describe the first reported case of Mycobacterium chelonae-related interface keratitis after Descemet membrane endothelial keratoplasty (DMEK), successfully treated with DMEK exchange.

Methods: A case of donor-related DMEK interface keratitis, treated with medical therapy and DMEK exchange, was studied retrospectively.

Results: A patient with Fuchs endothelial dystrophy developed infectious interface keratitis after DMEK. Read More

Genet Med 2019 Feb 8. Epub 2019 Feb 8.

UCL Institute of Ophthalmology, London, UK.

Purpose: To demonstrate the utility of an amplification-free long-read sequencing method to characterize the Fuchs endothelial corneal dystrophy (FECD)-associated intronic TCF4 triplet repeat (CTG18.1).

Methods: We applied an amplification-free method, utilizing the CRISPR/Cas9 system, in combination with PacBio single-molecule real-time (SMRT) long-read sequencing, to study CTG18. Read More

J Med Case Rep 2019 Feb 6;13(1):31. Epub 2019 Feb 6.

Department of Ophthalmology, University Hospital of Tübingen, Elfriede-Aulhorn-Str. 7, 72076, Tübingen, Germany.

Background: We report the first histopathologically proven occurrence of a retrocorneal membrane after Descemet's membrane endothelial keratoplasty.

Case Presentation: A white Caucasian 76-year-old woman received penetrating keratoplasty on her right eye 2 years after Descemet's membrane endothelial keratoplasty surgery with combined cataract extraction and intraocular lens implantation for Fuchs' endothelial corneal dystrophy due to an allograft rejection with ensuing graft failure. Her preoperative vision was counting fingers (20/2000) caused by immunological debris, corneal edema, and secondary membrane formation. Read More

Cornea 2019 Feb 1. Epub 2019 Feb 1.

Division of Ophthalmology, NorthShore University HealthSystem, Glenview, IL.

Purpose: Fuchs corneal dystrophy (FD) is a common cause of endothelial keratoplasty. Recently, a series of FD cases treated with Descemet stripping only (DSO) demonstrated recovery of the central endothelium without transplantation of donor cells. Ripasudil, a rho kinase inhibitor, has been shown to promote corneal endothelial wound healing in animal models. Read More

Ophthalmology 2019 Feb;126(2):205-206

PLoS One 2019 25;14(1):e0210996. Epub 2019 Jan 25.

Tissue Engineering and Stem Cell Group, Singapore Eye Research Institute, Singapore, Singapore.

Purpose: To determine if CTG18.1 TNR expansion length prognosticates the clinical progression of Fuchs' Endothelial Corneal Dystrophy (FECD).

Methods: This was a prospective cohort study. Read More

Cornea 2019 Jan 22. Epub 2019 Jan 22.

Cornea Unit, Department of Ophthalmology, Ramón y Cajal University Hospital. Madrid, Spain.

Purpose: To characterize pachymetric, keratometric, and surface elevation parameters in pseudophakic eyes with Fuchs dystrophy that underwent Descemet membrane endothelial keratoplasty (DMEK) and to compare these characteristics with those in normal pseudophakic eyes.

Methods: Postoperative corneal tomography with a median follow-up of 20 months was evaluated using the Pentacam tomographer on 46 DMEK eyes. Results were compared with data from an age-matched cohort of 46 normal eyes. Read More

Nucleic Acid Ther 2019 Jan 24. Epub 2019 Jan 24.

1 Department of Pharmacology and Biochemistry, UT Southwestern Medical Center at Dallas, Dallas, Texas.

Fuchs' endothelial corneal dystrophy (FECD) leads to vision loss and is one of the most common inherited eye diseases. Corneal transplants are the only curative treatment available, and there is a major unmet need for treatments that are less invasive and independent of donor tissue. Most cases of FECD are associated with an expanded CUG repeat within the intronic region of TCF4 and the mutant RNA has been implicated as the cause of the disease. Read More

Cornea 2019 Jan 21. Epub 2019 Jan 21.

Division of Cornea and Refractive Surgery, Department of Ophthalmology, Duke University Eye Center, Durham, NC.

Purpose: To evaluate whether lens status influences clinical outcomes of Descemet membrane endothelial keratoplasty (DMEK) in patients who underwent DMEK in phakia, pseudophakia, or combined with cataract surgery (triple).

Methods: A retrospective review of 139 eyes (107 patients) with symptomatic Fuchs' dystrophy or secondary corneal edema was performed. Patients were divided into 3 groups: 1) DMEK + cataract surgery, 2) DMEK in pseudophakia, and 3) DMEK in phakia. Read More

Curr Pharm Des 2019 Jan 15. Epub 2019 Jan 15.

Chronic Diseases Research Unit, Department of Medical Technology, Faculty of Allied Health Sciences, Naresuan University, Naresuan University, 99 Moo 9 Tambon Tha Pho, Muang Phitsanulok 65000. Thailand.

Background: Oxidative stress, an increased free radicals or oxidant productions result in cellular degeneration and neurodegeneration by damage all macromolecules, inducing lipid peroxidation, protein modification, DNA damage and apoptosis or cell death.

Methods: Accumulation of the DNA damage (8HOdG) products and the end products of LPO (including aldehyde, diene, triene conjugates and Schiff's bases) were noted in the research studies. Significant higher in the levels of these products in comparison with the control were observed. Read More

Am J Ophthalmol 2019 Mar 3;199:259-260. Epub 2019 Jan 3.

Singapore.

Mol Diagn Ther 2019 Feb;23(1):97-112

Department of Ophthalmology, New Zealand National Eye Centre, Faculty of Medical and Health Sciences, University of Auckland, Private Bag 92019, Auckland, New Zealand.

Fuchs' endothelial corneal dystrophy (FECD) is a common disease resulting from corneal endothelial cell dysfunction. It is inherited in an autosomal dominant fashion with incomplete penetrance, and with a female bias. Approximately half of cases occur sporadically, and the remainder are familial. Read More

Exp Eye Res 2018 Dec 28;180:174-183. Epub 2018 Dec 28.

Eye Hospital, First Affiliated Hospital, Harbin Medical University, 23 Youzheng Street, Harbin, 150001, China. Electronic address:

Fuchs endothelial dystrophy (FED) and late cornea allograft failure of cornea transplantation are associated with human corneal endothelial cells (HCEC) senescence. Kojic acid has various functions, however, its anti-senescence effect has never been identified. In this study, we investigated the anti-senescence effect of kojic acid on HCEC. Read More

Am J Ophthalmol 2019 Mar 19;199:258-259. Epub 2018 Dec 19.

Rochester, Minnesota, USA.

Clin Exp Ophthalmol 2018 Dec 22. Epub 2018 Dec 22.

Department of Ophthalmology, University of Cologne, Cologne, Germany.

Cornea 2019 Mar;38(3):280-284

Department of Ophthalmology, Rothschild Foundation, Paris, France.

Purpose: To demonstrate the feasibility of Descemet membrane endothelial keratoplasty (DMEK) performed after previous penetrating keratoplasty (PK) failure and to describe primary outcomes.

Methods: Twenty-eight eyes of 28 patients who underwent DMEK after primary PK failure between January 2013 and November 2017 were included in this single-center retrospective study. Best spectacle-corrected visual acuity, endothelial cell density, and the recipient's central corneal thickness were recorded preoperatively and at 1, 3, and 6 months after surgery. Read More

Indian J Ophthalmol 2019 Jan;67(1):148-150

Department of Ophthalmology, The University of Texas Medical Branch College of Medicine, Galveston; Department of Ophthalmology, Blanton Eye Institute, Houston Methodist Hospital, Houston; Department of Ophthalmology, Houston Methodist Eye Associates, Houston Methodist Hospital, Houston, TX; Department of Ophthalmology, Weill Cornell Medicine, New York, NY, USA.

A 75-year-old male with a right eye history of chronic dry eye syndrome, glaucoma status post tube shunt, and Fuchs dystrophy status post Descemet stripping endothelial keratoplasty followed by penetrating keratoplasty (PKP) presented with a 2.7 × 4.2 mm corneal ulcer, culture positive for Shewanella algae and Klebsiella oxytoca. Read More

J BUON 2018 Sep-Oct;23(5):1563-1568

Department of History of Medicine, Medical School, National and Kapodistrian University of Athens, Athens, Greece.

Born in Vienna, in mid 19th century, Ernst Fuchs became an innovative ophthalmologist and is currently considered as the father of modern ophthalmology. Conditions like heterochromic uveitis and endothelial dystrophy were discovered by Fuchs and a series of ocular diseases are named after him. His work dealing with eye pathology, entitled: "Textbook of Ophthalmology", became known as the masterpiece of the 19th century ophthalmology. Read More

Ther Adv Ophthalmol 2018 Jan-Dec;10:2515841418815802. Epub 2018 Dec 7.

Ophthalmic Research Center, Labbafinejad Medical Center, Shahid Beheshti University of Medical Sciences, Tehran 16666, Iran.

A transparent cornea is essential for the formation of a clear image on the retina. The human cornea is arranged into well-organized layers, and each layer plays a significant role in maintaining the transparency and viability of the tissue. The endothelium has both barrier and pump functions, which are important for the maintenance of corneal clarity. Read More

Exp Eye Res 2018 Dec 14;180:86-91. Epub 2018 Dec 14.

School of Optometry, Indiana University Bloomington, Bloomington, IN, USA. Electronic address:

SLC4A11 mutations are associated with Fuchs' endothelial corneal dystrophy (FECD), congenital hereditary endothelial dystrophy (CHED) and Harboyan syndrome (endothelial dystrophy with auditory deficiency). Mice with genetically ablated Slc4a11 recapitulate CHED, exhibiting significant corneal edema and altered endothelial morphology. We recently demonstrated that SLC4A11 functions as an NH sensitive, electrogenic H transporter. Read More

Eye (Lond) 2018 Dec 5. Epub 2018 Dec 5.

Department of Ophthalmology, Rabin Medical Center, Petach Tikva, Israel.

Purpose: To assess Descemet's membrane endothelial keratoplasty (DMEK) without performing a peripheral iridotomy (PI) prior to or during surgery ("PI-less DMEK").

Materials And Methods: This retrospective study included consecutive patients that underwent PI-less DMEK by a single surgeon (E.L) between February 2016 and February 2017 at the Rabin Medical Center, a Tertiary Hospital. Read More

Antioxidants (Basel) 2018 Dec 4;7(12). Epub 2018 Dec 4.

Tissue Engineering and Stem Cell group, Singapore Eye Research Institute (SERI), Singapore 169856, Singapore.

The inner layer of the cornea, the corneal endothelium, is post-mitotic and unable to regenerate if damaged. The corneal endothelium is one of the most transplanted tissues in the body. Fuchs' endothelial corneal dystrophy (FECD) is the leading indication for corneal endothelial transplantation. Read More

Can J Ophthalmol 2018 Dec 9;53(6):580-587. Epub 2018 May 9.

Keenan Research Centre at the Li Ka Shing Knowledge Institute of St. Michael's Hospital, Toronto, Ont; Department of Ophthalmology and Vision Sciences, Faculty of Medicine, University of Toronto, Toronto, Ont; Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, Ont; Dalla Lana School of Public Health, University of Toronto, Toronto, Ont.. Electronic address:

Objective: To assess trends in surgical procedures and indications for all corneal transplants performed at the University of Toronto.

Design: Retrospective cross-sectional study.

Participants: One thousand one hundred and four consecutive corneal transplants performed at the Kensington Eye Institute (KEI). Read More

Am J Ophthalmol 2019 Mar 28;199:150-158. Epub 2018 Nov 28.

Netherlands Institute for Innovative Ocular Surgery (NIIOS), Rotterdam, Netherlands; Melles Cornea Clinic Rotterdam, Rotterdam, Netherlands; Amnitrans EyeBank Rotterdam, Rotterdam, Netherlands; NIIOS-USA, San Diego, California, USA. Electronic address:

Purpose: To evaluate the feasibility and clinical outcomes of Descemet membrane endothelial keratoplasty (DMEK) in eyes with a glaucoma drainage device (GDD).

Design: Retrospective, interventional case series.

Methods: Clinical outcomes of 23 DMEK procedures for bullous keratopathy (52%), failed previous transplant (39%), or Fuchs endothelial corneal dystrophy (9%) in 20 eyes (19 patients) with a GDD were retrospectively analyzed at 2 tertiary referral centers. Read More

PLoS One 2018 29;13(11):e0207891. Epub 2018 Nov 29.

Department of Surgical Sciences, Eye Clinic, University of Cagliari, Cagliari, Italy.

Purpose: To evaluate the feasibility of 3D anterior segment optical coherence tomography (AS-OCT) for the detection of corneal endothelial features in patients with Fuchs' Endothelial Corneal Dystrophy (FECD).

Methods: Twenty patients with clinical diagnosis of FECD (group A), and 20 control subjects (group B) were enrolled. In all patients a complete ophthalmological examination was performed, including best corrected visual acuity (BCVA), slit lamp examination for subjective grading of FECD and corneal endothelial specular microscopy. Read More

Invest Ophthalmol Vis Sci 2018 Nov;59(13):5627-5632

Laboratory for Ultrasonic Nondestructive Evaluation "LUNE", UMI Georgia Tech-CNRS 2958, Metz, France.

Purpose: To describe the application of scanning acoustic microscopy in the GHz-range (GHz-SAM) for qualitative imaging and quantitative characterization of the micromechanical properties of the Descemet's membrane and endothelial cells of cornea tissue.

Methods: Investigated were samples of a normal tissue and a tissue with Fuchs' endothelial dystrophy (FECD, cornea Guttata). Descemet's membranes were fixed on glass substrates and imaged utilizing a focused acoustic lens operating at a center frequency of 1 GHz. Read More

Ophthalmologe 2018 Nov 26. Epub 2018 Nov 26.

Zentrum für Augenheilkunde, Universität zu Köln, Kerpenerstr. 62, 50924, Köln, Deutschland.

Background: Descemet membrane endothelial keratoplasty (DMEK) has become the standard surgical treatment for Fuchs' endothelial corneal dystrophy (FECD) in Germany. In addition to classical FECD, there are endothelial disorders amenable to DMEK associated with complex changes in the anterior segment of the eye, such as anterior synechia of the iris, larger iris defects, after glaucoma surgery, after vitrectomy and after trauma.

Objective: This article provides an overview of the possibilities to treat patients with complex anterior segment situations in the presence of corneal endothelial decompensation with DMEK. Read More

Exp Eye Res 2018 Nov 22;180:18-22. Epub 2018 Nov 22.

Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, CA, United States; Department of Ophthalmology & Vision Sciences, School of Medicine, University of California, Davis, CA, United States. Electronic address:

Early-onset Fuchs endothelial corneal dystrophy (FECD) has been associated with nonsynonymous mutations in collagen VIII α2 (COL8A2), a key extracellular matrix (ECM) protein in Descemet's membrane (DM). Two knock-in strains of mice have been generated to each express a mutant COL8A2 protein (Col8a2 and Col8a2) that recapitulate the clinical phenotype of early-onset FECD including endothelial cell loss, cellular polymegathism and pleomorphism, and guttae. Due to abnormalities in ECM protein composition and structure in FECD, the stiffness of DM in Col8a2 knock-in mice and wildtype (WT) controls was measured using atomic force microscopy at 5 and 10 months of age, coinciding with the onset of FECD phenotypic abnormalities. Read More

Exp Eye Res 2019 Feb 13;179:188-192. Epub 2018 Nov 13.

Department of General Ophthalmology, Medical University of Lublin, Chmielna 1, 20-079, Lublin, Poland; Mossakowski Medical Research Centre Polish Academy of Sciences, Pawinskiego 5, 02-106, Warsaw, Poland. Electronic address:

We provide the evidence for G protein-coupled receptor 35 (GPR35) presence and distribution in the human cornea. The initial data on GPR35 gene expression were retrieved from microarray repositories and were further confirmed by western blotting and immunohistochemical analysis. Immunoblotting suggested that GPR35 exists predominantly as a dimer in corneal tissue. Read More

Cornea 2019 Feb;38(2):252-255

Department of Ophthalmology, Rabin Medical Center, Petach Tikva, Israel.

Purpose: To describe the ghost Descemet's membrane endothelial keratoplasty (DMEK) technique that allows for real-time evaluation of DMEK graft orientation, location, and folding status within the anterior chamber, by simple observation at the surgical microscope.

Methods: This is a retrospective case series done in a university hospital. The study included 10 patients who underwent ghost DMEK surgery because of corneal endothelial insufficiency for Fuchs' endothelial dystrophy (N = 5), pseudophakic bullous keratopathy (N = 2), and failed previous posterior lamellar keratoplasty (N = 3). Read More

JAMA Ophthalmol 2018 Oct 26. Epub 2018 Oct 26.

Verdier Eye Center, Grand Rapids, Michigan.

Importance: Determining factors associated with endothelial cell loss after Descemet stripping automated endothelial keratoplasty (DSAEK) could improve long-term graft survival.

Objective: To evaluate the associations of donor, recipient, and operative factors with endothelial cell density (ECD) 3 years after DSAEK in the Cornea Preservation Time Study.

Design, Setting, And Participants: This cohort study was a secondary analysis of data collected in a multicenter, double-masked, randomized clinical trial. Read More

Cornea 2019 Jan;38(1):30-34

Department of Ophthalmology, St. Paul's Eye Unit, Royal Liverpool University Hospital, Liverpool, United Kingdom.

Purpose: To evaluate the clinical outcomes of preloaded large-diameter ultra-thin grafts for Descemet stripping automated endothelial keratoplasty (UT-DSAEK) after cross-country shipment.

Methods: A laboratory study in an eye bank and a clinical cohort study in an academic tertiary care center were performed. UT-DSAEK (9. Read More

Ophthalmologe 2018 Nov 6. Epub 2018 Nov 6.

Klinik für Augenheilkunde, Universitätsklinikum Freiburg, Killianstr. 5, 79106, Freiburg, Deutschland.

Background: Following new treatment options for Fuchs' endothelial corneal dystrophy, our understanding of optical and structural changes in the patient's cornea is also starting to improve.

Objective: To provide an update on clinical evaluation of Fuchs' dystrophy.

Material And Methods: Standardized approaches to evaluate patients with Fuchs dystrophy in routine practice and research are discussed, accounting for the progressive and partially irreversible structural changes in all corneal layers. Read More

Cont Lens Anterior Eye 2019 Feb 2;42(1):92-103. Epub 2018 Nov 2.

OD, Private practice, Miami, USA. Electronic address:

Research and reviews have resulted in clear indications for scleral lens (SL) wear. Those indications include visual rehabilitation; therapeutic use in managing ocular surface diseases, lid and orbit disorders; and refractive correction to enhance visual quality, comfort and quality of life. In some cases, the use of SLs may be contraindicated: the presence of low endothelial cell density; Fuchs' endothelial corneal dystrophy; glaucoma (because of the risk of an increase in intraocular pressure and the existence and location of draining devices and blebs); or overnight wear. Read More

Med Hypothesis Discov Innov Ophthalmol 2018 ;7(3):101-111

HDR Research Center, Hoopes Vision, 11820 S. State Street Suite #200, Draper, UT 84020, USA.

The use of Rho Kinase (ROCK) inhibitors as therapeutic agents in ophthalmology has been a topic of discussion for several years, particularly in the realm of glaucoma, Fuchs' endothelial dystrophy, and diabetic retinopathy. In this review, the authors provide a detailed and comprehensive overview of the published literature on the use of Rho kinase inhibitors for the aforementioned purposes. A thorough search of several databases was conducted to find sufficient literature on ROCK inhibitors. Read More

Ophthalmologe 2018 Oct 26. Epub 2018 Oct 26.

Zentrum für Augenheilkunde, Universitätsklinik Köln, Kerpener Str. 62, 50924, Köln, Deutschland.

Background And Objective: Descemet membrane endothelial keratoplasty (DMEK) has increased in popularity since its introduction over 10 years ago. This article presents a summary of the experiences of the past years collected at the Department of Ophthalmology at the University of Cologne.

Methods: A literature review of DMEK studies primarily from the Department of Ophthalmology at the University of Cologne, Germany was carried out. Read More

Cornea 2019 Feb;38(2):166-172

Netherlands Institute for Innovative Ocular Surgery, Rotterdam, The Netherlands.

Purpose: To study the influence of different intraoperative air tamponade times on graft adherence after Descemet membrane endothelial keratoplasty (DMEK).

Methods: In this interventional case series, we evaluated 117 eyes with Fuchs endothelial corneal dystrophy (FECD) that underwent DMEK using intraoperative air tamponade times of 60 minutes (group I; n = 39), 45 minutes (group II; n = 39), or 30 minutes (group III; n = 39). At 1 and 6 months postoperatively, graft adherence status, endothelial cell density, central pachymetry, and postoperative complications were recorded. Read More

Curr Eye Res 2019 Feb 29;44(2):147-153. Epub 2018 Oct 29.

a Department of Ophthalmology , Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität Berlin, and Berlin Institute of Health , Berlin , Germany.

Purpose: The purpose of this study is to identify predictors for the best-corrected visual acuity (BCVA), central corneal thickness (CCT), and the endothelial cell density (ECD) after primary Descemet's membrane endothelial keratoplasty (DMEK).

Methods: In a prospective observational study, 108 eyes with Fuchs' endothelial dystrophy underwent a primary DMEK. Preoperative data, histologic parameters from host's Descemet's membrane, and follow-up data of the first eye were analyzed in regard to BCVA, CCT, and ECD, 12 months after surgery. Read More

Cornea 2019 Jan;38(1):24-29

Department of Ophthalmology, Eye Clinic Sulzbach, Knappschaft Hospital Saar, Sulzbach/Saar, Germany.

Purpose: To compare the clinical outcome after Descemet membrane endothelial keratoplasty (DMEK) either as precut or conventional Descemet membrane graft preparation under standard European eye bank organ culture conditions.

Methods: This was a prospective pilot study of patients receiving either precut or conventional DMEK. Graft preparation was performed using the liquid bubble technique. Read More

Acta Ophthalmol 2018 Oct 14. Epub 2018 Oct 14.

Department of Ophthalmology, University of Cologne, Cologne, Germany.

Purpose: To assess the effect of donor tissue diameter in Descemet Membrane Endothelial Keratoplasty (DMEK) on postoperative endothelial cell density (ECD) mainly in Fuchs Endothelial Corneal Dystrophy (FECD) patients.

Methods: Retrospective review of 693 consecutive DMEK surgeries from the prospective Cologne DMEK database performed between 07/2011 and 07/2016 at the Department of Ophthalmology, University of Cologne. Eight- versus ten-millimetre large donor DMEK grafts of two different surgeons using identical surgical techniques were compared. Read More

Cornea 2018 Nov;37 Suppl 1:S50-S54

Department of Ophthalmology, Harvard Medicial School, and Schepens Eye Research Institute, Massachusetts Eye and Ear, Boston, MA.

The corneal endothelium (CE) is vital for maintaining the water balance and clarity of the cornea. The CE is a cell layer that is particularly susceptible to aging because of its postmitotic arrest, high metabolic activity involving pumping of ions, and lifelong exposure to ultraviolet light. Despite gradual age-related cell loss, a sufficient number of CE cells are preserved during the lifespan of an individual. Read More

PLoS One 2018 5;13(10):e0203993. Epub 2018 Oct 5.

Rotterdam Eye Hospital, Rotterdam, The Netherlands.

Objective: Comparison of conventional Penetrating Keratoplasty (PKP), posterior mushroom PKP and Descemet's Stripping Automated Endothelial Keratoplasty (DSAEK) regarding overall graft survival of primary corneal transplants for Fuchs´ endothelial dystrophy (FED), best spectacle-corrected visual acuity (BSCVA) and astigmatism.

Methods: Single centre study using prospectively collected data from the national database for follow-up of corneal transplants. Main outcome parameters: 10 years graft survival, astigmatism at 24 months, pre- and post-operative BSCVA. Read More

Ophthalmology 2019 Feb 28;126(2):207-213. Epub 2018 Sep 28.

Bascom Palmer Eye Institute, University of Miami, Miami, Florida.

Purpose: To determine the cost-effectiveness of Descemet's membrane endothelial keratoplasty (DMEK) compared with Descemet's stripping automated endothelial keratoplasty (DSAEK) in the United States.

Design: Cost-effectiveness analysis in a surgical center in the United States.

Participants: Binocular adult patient undergoing endothelial keratoplasty. Read More

Invest Ophthalmol Vis Sci 2018 Sep;59(11):4748-4754

S. Fyodorov Eye Microsurgery Complex Federal State Institution, Ministry of Health of Russian Federation, Moscow, Russia.

Purpose: To assess the occurrence and diagnostic performance of nine single-nucleotide variants (SNVs) in the TCF4, SLC4A11, LOXHD1, and AGBL1 genes and the CTG18.1 trinucleotide repeat expansion in a Russian cohort of Fuchs' endothelial corneal dystrophy (FECD) patients.

Methods: This retrospective case-control study included 100 patients diagnosed with FECD (cases) and 100 patients with cataracts (controls). Read More

PLoS One 2018 27;13(9):e0204278. Epub 2018 Sep 27.

School of Biological Sciences, National Institute of Science Education and Research (NISER) Bhubaneswar, HBNI, P.O. Bhimpur-Padanpur, Jatni, Khurda, Odisha, India.

Fuchs' Endothelial Corneal Dystrophy (FECD) is a genetically complex disorder that affects individuals above 40 years of age; molecular pathogenesis of its associated genes is poorly understood. This study aims at assessing the association of flap endonuclease 1 (FEN1) polymorphisms, c.-69G>A (rs174538) and c. Read More

Cornea 2018 Nov;37 Suppl 1:S74-S77

Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.

Fuchs endothelial corneal dystrophy (FECD) is a bilateral progressive corneal endothelial disease characterized by guttae, which present as partial Descemet membrane thickening, inducing corneal edema at the final stage. Oxidative stress has been reported to play an important role in the pathogenesis of FECD. The electron transport chain and oxidative phosphorylation (oxphos) system in mitochondria are the main sources of endogenous oxidative stress, arising from superoxide generation through premature electron leakage to oxygen. Read More

Indian J Ophthalmol 2018 Oct;66(10):1478-1480

Department of Cornea, Anterior Segment and Refractive Services, C L Gupta Eye Institute, Ram Ganga Vihar Phase II, Moradabad, Uttar Pradesh, India.

We report a case of a 46-year-old female who developed infectious crystalline keratopathy (ICK) after Descemet's stripping endothelial keratoplasty (DSEK). She underwent DSEK for pseudophakic corneal edema in her left eye. Ten weeks after the procedure, the patient presented with complaints of blurred vision, redness in eye, and ocular pain. Read More

Am J Ophthalmol Case Rep 2018 Dec 6;12:65-67. Epub 2018 Sep 6.

Department of Ophthalmology, St. Paul's Eye Unit, Royal Liverpool University Hospital, Liverpool, United Kingdom.

Purpose: To report the management of an intraoperative complication during large (9.5 mm) ultra-thin Descemet Stripping Automated Endothelial Keratoplasty (UT-DSAEK) surgery in a patient with a large area of dysfunctional endothelium.

Observations: A single case study of an 89 y/o male with a history of Fuchs corneal endothelial dystrophy is presented. Read More

Acta Ophthalmol 2018 Dec 21;96(8):e970-e973. Epub 2018 Sep 21.

Department of Ophthalmology, Eberhard-Karls University, Tuebingen, Germany.

Purpose: To confirm the reproducibility of manual graft preparation using curvilinear forceps and evaluate the incidence and type of structural abnormalities of Descemet's membrane (DM) preventing successful grafts preparation.

Methods: Five hundred corneo-scleral buttons were prepared. Factors such as endothelial cell number before preparation, donor age, post-mortem time, time in culture, pigmentation of the trabecular meshwork and preparation characteristics of the fellow eye were analysed. Read More