73,666 results match your criteria Dysplasia Epiphysealis Hemimelica


A multimodal (FACILE) classification for optical diagnosis of inflammatory bowel disease associated neoplasia.

Endoscopy 2018 Dec 12. Epub 2018 Dec 12.

Division of Gastroenterology, HSK Hospital, Wiesbaden, Germany.

Background:  Characterization of colonic lesions in inflammatory bowel disease (IBD) remains challenging. We developed an endoscopic classification of visual characteristics to identify colitis-associated neoplasia using multimodal advanced endoscopic imaging (Frankfurt Advanced Chromoendoscopic IBD LEsions [FACILE] classification).

Methods:  The study was conducted in three phases: 1) development - an expert panel defined endoscopic signs and predictors of dysplasia in IBD and, using multivariable logistic regression created the FACILE classification; 2) validation - using 60 IBD lesions from an image library, two assessments of diagnostic accuracy for neoplasia were performed and interobserver agreement between experts using FACILE was determined; 3) reproducibility - the reproducibility of the FACILE classification was tested in gastroenterologists, trainees, and junior doctors after completion of a training module. Read More

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December 2018

Wide-area transepithelial sampling with computer-assisted 3-dimensional analysis (WATS) markedly improves detection of esophageal dysplasia and Barrett's esophagus: analysis from a prospective multicenter community-based study.

Dis Esophagus 2018 Dec 12. Epub 2018 Dec 12.

Gastroenterology, New York University Langone Medical Center, New York, NY, USA.

The 4-quadrant forceps biopsy (FB) protocol for identifying Barrett's esophagus (BE) and esophageal dysplasia (ED) suffers from poor sensitivity due to significant sampling error. We investigated the benefit of wide-area transepithelial sampling with 3-dimensional computer-assisted analysis (WATS) used adjunctively to the combination of random and targeted FB in the detection of ED, and as a secondary outcome, BE. In this multicenter prospective trial, community endoscopists at 21 sites utilized WATS as an adjunct to both targeted and random FB in patients undergoing BE screening and surveillance. Read More

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December 2018
2 Reads

Comparison of ground reaction force measurements in a population of Domestic Shorthair and Maine Coon cats.

PLoS One 2018 12;13(12):e0208085. Epub 2018 Dec 12.

Department for Companion Animals and Horses, University Clinic for Small Animals, Small Animal Surgery, Section for Physical Therapy, University of Veterinary Medicine, Veterinärplatz, Vienna, Austria.

Current research on gait analysis mostly involves horses and dogs. Feline kinetics and kinematics are being investigated and receiving more clinical interest at present. Ground reaction forces measured on pressure-sensitive mattresses have been established in healthy Domestic Shorthair cats (DSH). Read More

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December 2018

Impact of surfactant administration through a thin catheter in the delivery room: A quality control chart analysis coupled with a propensity score matched cohort study in preterm infants.

PLoS One 2018 12;13(12):e0208252. Epub 2018 Dec 12.

Department of Pediatrics, University of Rennes 1,Rennes, France.

Introduction: Most infants born before 30 weeks gestational age (GA) develop respiratory distress syndrome soon after birth. Methods of surfactant administration that avoid ventilation have been recently introduced. The aim of this study was to evaluate the impact of implementing a new procedure of less invasive surfactant administration (LISA) and determine whether it is associated with an improvement in respiratory outcome. Read More

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December 2018

Diagnostic and Prognostic Impact of Neutrophil-to-Lymphocyte Ratio for Intraductal Papillary Mucinous Neoplasms of the Pancreas With High-Grade Dysplasia and Associated Invasive Carcinoma.

Pancreas 2019 Jan;48(1):99-106

From the Departments of Surgery.

Objectives: The aim of this study was to evaluate the diagnostic and prognostic impact of systemic inflammatory markers for IPMN with high-grade dysplasia (HGD)/invasive carcinoma.

Methods: Neutrophil-to-lymphocyte ratio (NLR), derived NLR, platelet-to-lymphocyte ratio, and C-reactive protein-to-albumin ratio were compared across the different histological grades of 205 IPMN cases. We also tested the diagnostic performance for IPMN with HGD/invasive carcinoma. Read More

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January 2019

Hypohidrotic Ectodermal Dysplasia: A Rare Disorder with Bilateral Infantile Glaucoma.

J Glaucoma 2018 Dec 11. Epub 2018 Dec 11.

Glaucoma and anterior segment, Dr. Shroff's charity eye hospital, Delhi.

Ectodermal dysplasia is a disorder that occurs due to abnormalities of ectodermal structures such as skin, teeth, hair, nails, and eccrine glands. Approximately 200 different conditions have been identified as ectodermal dysplasia, the most common being hypohidrotic ectodermal dysplasia (HED). It is characterized by hypotrichosis (sparse scalp or body hair), hypodontia (absent or malformed teeth) and hypohidrosis (reduced ability to sweat). Read More

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December 2018
2 Reads

Evaluation of dual pathology among drug-resistant epileptic patients with hippocampal sclerosis.

Neurol Sci 2018 Dec 11. Epub 2018 Dec 11.

Isfahan Neurosciences Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.

Purpose: Dual pathology (DP) is defined as simultaneous presence of hippocampal sclerosis (HS) and any other pathology in the brain. Since this is a less probed concept, we aimed to evaluate the frequency and characteristics of DP among drug-resistant epileptic patients with HS.

Methods: This is a cross-sectional study conducted during 2007-2016 in Kashani Comprehensive Epilepsy Center, Isfahan, Iran. Read More

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December 2018

Identification of salivary metabolites for oral squamous cell carcinoma and oral epithelial dysplasia screening from persistent suspicious oral mucosal lesions.

Clin Oral Investig 2018 Dec 11. Epub 2018 Dec 11.

Department of Dentistry, Oral and Maxillofacial Plastic and Reconstructive Surgery, Faculty of Medicine, Yamagata University, 2-2-2 Iida-nishi, Yamagata, 990-9585, Japan.

Objective: To identify salivary metabolite biomarkers to differentiate patients with oral squamous cell carcinoma and oral epithelial dysplasia (OSCC/OED) from those with persistent suspicious oral mucosal lesions (PSOML).

Subjects And Methods: Whole unstimulated saliva samples were collected from age-, sex-, and race-matched patients who had a lesion in the oral cavity and for whom open biopsies were performed. The patients included OSCC (n = 6), OED (n = 10), and PSOML (n = 32). Read More

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December 2018

Application of MRI Post-processing in Presurgical Evaluation of Non-lesional Cingulate Epilepsy.

Front Neurol 2018 27;9:1013. Epub 2018 Nov 27.

Epilepsy Center, Cleveland Clinic, Cleveland, OH, United States.

Surgical management of patients with cingulate epilepsy (CE) is highly challenging, especially when the MRI is non-lesional. We aimed to use a voxel-based MRI post-processing technique, implemented in a morphometric analysis program (MAP), to facilitate detection of subtle epileptogenic lesions in CE, thereby improving surgical evaluation of patients with CE with non-lesional MRI by visual inspection. Included in this retrospective study were 9 patients with CE (6 with negative 3T MRI and 3 with subtly lesional 3T MRI) who underwent surgery and became seizure-free or had marked seizure improvement with at least 1-year follow-up. Read More

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November 2018

First two cases of craniomaxillofacial fibrous dysplasia from Nepal - case series.

Clin Cosmet Investig Dent 2018 26;10:269-274. Epub 2018 Nov 26.

Department of Oral and Maxillofacial Surgery, Chitwan Medical College and Teaching Hospital, Bharatpur-10, Chitwan, Nepal.

Fibrous dysplasia is a benign fibro-osseous disease of the bone, which is most commonly associated with congenital mutations in cAMP regulating protein Gsα coded by gene. Often it is seen involving the craniofacial skeleton and can range from an asymptomatic monostotic form to polyostotic variant involving almost all the bones of the skull, thereby leading to functional and esthetic problems. This requires a continuous monitoring of the involved region throughout the life of the patient, even after the surgical interventions. Read More

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November 2018

A novel de novo mutation in a patient with Holt-Oram syndrome.

Appl Clin Genet 2018 23;11:157-162. Epub 2018 Nov 23.

Center for Research on Congenital Anomalies and Rare Diseases (CIACER), Department of Basic Medical Sciences, Universidad Icesi, Cali, Valle del Cauca, Colombia,

Holt-Oram syndrome (HOS) is an autosomal dominant disorder characterized by congenital cardiac defects and congenital deformities of the upper limbs. Herein, we report the case of a 2-year-old patient presenting with clinical diagnostic criteria of HOS with interatrial and interventricular communication associated with hip dysplasia and upper limb reduction composed of radial ray anomaly. A novel de novo, potentially pathogenic variant in the gene at NM_181486. Read More

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November 2018

Neonatal intermittent hypoxemia events are associated with diagnosis of bronchopulmonary dysplasia at 36 weeks postmenstrual age.

Pediatr Res 2018 Dec 12. Epub 2018 Dec 12.

Division of Neonatology, Rainbow Babies & Children's Hospital, Department of Pediatrics, Case Western Reserve University, Cleveland, OH, USA.

Background: Bronchopulmonary dysplasia (BPD) is a chronic lung disease and major pulmonary complication after premature birth. We have previously shown that increased intermittent hypoxemia (IH) events have been correlated to adverse outcomes and mortality in extremely premature infants. We hypothesize that early IH patterns are associated with the development of BPD. Read More

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December 2018

TNFα-stimulated protein 6 (TSG-6) reduces lung inflammation in an experimental model of bronchopulmonary dysplasia.

Pediatr Res 2018 Dec 11. Epub 2018 Dec 11.

Department of Pediatrics, University of Miami Miller School of Medicine, Miami, FL, USA.

Background: Inflammation is a key factor in the pathogenesis of bronchopulmonary dysplasia (BPD). Tumor necrosis factor-stimulated protein 6 (TSG-6) is a glycoprotein that modulates inflammation. Here we tested the hypothesis that intra-tracheal (IT) administration of an adenovirus overexpressing TSG-6 (AdTSG-6) would decrease inflammation and restore lung structure in experimental BPD. Read More

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December 2018

Iliac artery fibromuscular dysplasia successfully treated by balloon angioplasty guided by intravascular ultrasound and pressure wire measurements: A case report.

J Cardiol Cases 2014 May 28;9(5):203-207. Epub 2014 Feb 28.

Department of Cardiology, Kishiwada Tokushukai Hospital, Osaka, Japan.

A 71-year-old woman was admitted with a 6-month history of lower limb intermittent claudication. She had well-controlled hypertension and no other risk factor of atherosclerosis. Angiographic findings revealed the "string of beads" pattern in bilateral renal arteries and external iliac arteries. Read More

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Successful coronary intervention for spontaneous coronary dissection in a patient with fibromuscular dysplasia.

J Cardiol Cases 2013 Nov 2;8(5):158-160. Epub 2013 Oct 2.

Department of Cardiology and Renal Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu 807-8556, Japan.

Spontaneous coronary artery dissection (SCAD) is a reported rare cause of acute coronary syndrome (ACS) and sudden death among middle-aged women. Some institutes have recently reported fibromuscular dysplasia (FMD) concomitant with SCAD. Therefore, a survey of the presence of comorbid FMD in SCAD patients is important to obtain a definitive diagnosis and for the prediction of possible SCAD recurrence. Read More

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November 2013

In vivo intravascular ultrasound imaging of fibromuscular dysplastic region and intravascular pressure gradient-guided percutaneous transluminal renal angioplasty.

J Cardiol Cases 2011 Dec 15;4(3):e163-e167. Epub 2011 Sep 15.

Department of Cardiovascular Medicine, Faculty of Life Sciences, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.

Fibromuscular dysplasia (FMD) is one of the etiologies of renal artery stenosis (RAS) and secondary hypertension. Balloon angioplasty has emerged as the mainstay of treatment because patients with FMD usually show substantial clinical and anatomic response to renal angioplasty without stenting. We report a 21-year-old male case of FMD-induced RAS treated with intravascular ultrasound- and pressure gradient-guided renal angioplasty. Read More

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December 2011

New onset hypertension-rare intimal variant fibromuscular dysplasia.

J Cardiol Cases 2011 Aug 21;4(1):e50-e54. Epub 2011 Jul 21.

Michigan State University/Kalamazoo Center for Medical Studies, Borgess Medical Center, Kalamazoo, MI, USA.

Fibromuscular dysplasia (FMD) involving the renal arteries commonly presents as hypertension secondary to renal artery stenosis. Atypical patterns involving intima are rare and contribute to less than 10% cases of FMD. We present a relatively uncommon case of new onset hypertension in a 30-year-old woman resulting from intimal variant FMD involving the left renal artery. Read More

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Systemic Arterial Hypertension in Childhood: A Challenge Related to the Increasing Survival of Very Low Birth Weight Preterm Infants.

Am J Perinatol 2018 Dec 11. Epub 2018 Dec 11.

Department of Pediatrics, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.

Objective:  To verify the prevalence of systemic arterial hypertension (SAH) and to identify possible early predictors of SAH at ages 2 and 4 years in very low birth weight (VLBW) infants.

Study Design:  This is a prospective cohort study including inborn children with birth weight (BW) <1,500 g. Arterial blood pressure measurements were performed at 2 and 4 years. Read More

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December 2018

Timing of postnatal corticosteroid treatment for bronchopulmonary dysplasia and its effect on outcomes.

Pediatr Pulmonol 2018 Dec 10. Epub 2018 Dec 10.

Division of Neonatology, Children's Mercy Kansas City, Kansas City, Missouri.

Objective: To determine the association of timing of steroid therapy for bronchopulmonary dysplasia (BPD) and outcomes.

Methods: Retrospective cohort study of preterm infants treated with low-dose dexamethasone for BPD. Infants treated with steroids at day of life (DOL) 14-28 (moderately late group) were compared to infants treated at DOL 29-42 (delayed group). Read More

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December 2018

High versus low dose caffeine in preterm infants.

Acta Paediatr 2018 Dec 11. Epub 2018 Dec 11.

Department of Paediatrics, Lund University, Skane University Hospital, Lund, Sweden.

We are grateful to Vliegenthart et al for their letter (1) commenting on our systematic review, which compared the use of high versus low dose caffeine in preterm infants (2). A clear definition of the inclusion criteria in a systematic review is an essential step to minimise the risk of intellectual bias. Vliegenthart et al state that pooling the results of the studies they identified did not affect the estimate of the effect size of the outcome of bronchopulmonary dysplasia. Read More

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December 2018

Dynamic changes of Sonic Hedgehog signaling pathway in gastric mucosa of rats with MNNG-induced gastric precancerous lesions.

J Cell Physiol 2018 Dec 7. Epub 2018 Dec 7.

Department of Digestive, Hangzhou Traditional Chinese Medical Hospital, Hangzhou, China.

Objective: To explore the changes of Sonic Hedgehog (Shh) signaling pathway in the stomach mucosa during the formation of gastric precancerous lesions.

Methods: A total of 72 suckling rats in half genders were randomly and equally divided into the normal group and model group. The rats in the model group were administered with 0. Read More

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December 2018

Model that predicted death or disabilities in premature infants was valid at seven years of age.

Acta Paediatr 2018 Dec 8. Epub 2018 Dec 8.

Neonatologist. 12 de Octubre University Hospital, Madrid, Spain.

Aim: Validated a model that used bronchopulmonary dysplasia (BPD), brain injuries measured using ultrasound and retinopathy of prematurity (ROP) to predict late death or disability in premature infants at seven years of age.

Methods: A retrospective study was performed at the 12 de Octubre Hospital neonatal unit in Madrid. A logistic model was applied to estimate the independent prognostic contribution of each morbidity and the effect that the combination of morbidities had on the seven-year outcomes. Read More

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December 2018

[Patellofemoral instability in children and adolescents].

Unfallchirurg 2018 Dec 7. Epub 2018 Dec 7.

AUVA Traumazentrum Wien, Standort Meidling, Kundratstr. 37, 1120, Wien, Österreich.

Dislocation of the patella is one of the most common knee injuries in childhood and adolescence. After detailed clinical and radiological clarification, conservative functional treatment with special orthotic devices is most commonly applied in patients with a primary dislocation without concomitant injuries; however, the redislocation rate after conservative treatment has been reported in the literature to be between 35% and 70%, depending on the risk factors present. Therefore, numerous surgical treatment options exist which are sometimes again associated with high redislocation rates and others can lead to early arthrosis of the patellofemoral joint when used indiscriminately. Read More

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December 2018

[Suspected vascular ehlers danlos syndrome. Case report].

Rev Med Chil 2018 Aug;146(8):938-942

Departamento de Dermatología, Pontificia Universidad Católica de Chile, Santiago, Chile.

Ehlers Danlos Syndrome comprises a heterogeneous group of genetic disorders of the connective tissue, due to defects in collagen or its modifying enzymes. We report a 21 years old male presenting with translucent skin revealing the subcutaneous venous pattern. He had a thin face, large-appearing eyes, thin lips, thin nose, joint hypermotility and history of hip dysplasia. Read More

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Non-invasive imaging techniques for early diagnosis of radiation-induced squamous cell carcinoma of the lip.

Rom J Morphol Embryol 2018 ;59(3):949-953

"Victor Babeş" National Institute for Research and Development in Pathology and Biomedical Sciences, Bucharest, Romania;

Ionizing radiation was used in the past for treatment of several benign cutaneous conditions, and particularly hemangiomas. Even though radiotherapy was generally effective, it significantly augmented the risk for malignancies, resulting in a consequent heavy decline of its use for benign conditions. However, radiation-induced neoplasia is still encountered in adult patients irradiated during childhood or adolescence. Read More

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January 2018

One-stage Hip Reconstruction for Developmental Hip Dysplasia in Children over 8 Years of Age.

Hip Pelvis 2018 Dec 6;30(4):260-268. Epub 2018 Dec 6.

Department of Orthopaedic and Spine Surgery, Ghurki Trust Teaching Hospital, Lahore, Pakistan.

Purpose: This study was performed to assess the clinical and radiological outcomes following one-stage hip reconstruction, consisting of open reduction femoral shortening and pelvic osteotomy, for neglected developmental dislocation of the hip (DDH).

Materials And Methods: This is a retrospective analysis of 77 hips in 65 patients (46 females and 19 males; 12 had bilateral dislocations), operated at a Ghurki Trust Teaching Hospital in Pakistan between 2013 and 2015. The average age at surgery was 11. Read More

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December 2018

Correlation of matrix metalloproteinase-9 expression with morphometric analysis of mucosal vasculature in oral squamous cell carcinoma, oral epithelial dysplasia, and normal oral mucosa.

Int J Health Sci (Qassim) 2018 Nov-Dec;12(6):36-43

Department of Oral Pathology, KLE Vishwanath Katti Institute of Dental Sciences, Belgaum, Karnataka, India.

Objective: Oral squamous cell carcinoma (OSCC) invades and metastasizes, by degrading the extracellular matrix (ECM) and is associated with poor prognosis. Matrix-metalloproteinase (MMP-9) can initiate ECM degradation and angiogenesis which brings a significant change in tumor microenvironment favoring tumor progression. A major thrust has been laid on understanding this key enzyme as it has significant implications for cancer therapy. Read More

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December 2018

Reactive Oxygen Species, Biomarkers of Microvascular Maturation and Alveolarization, and Antioxidants in Oxidative Lung Injury.

React Oxyg Species (Apex) 2018 Nov;6(18):373-388

Department of Pediatrics, Division of Neonatal-Perinatal Medicine, State University of New York, Downstate Medical Center, Brooklyn, NY 11203, USA.

The lungs of extremely low gestational age neonates (ELGANs) are deficient in pulmonary surfactant and are incapable of efficient gas exchange necessary for successful transition from a hypoxic intrauterine environment to ambient air. To improve gas exchange and survival, ELGANs often receive supplemental oxygen with mechanical ventilation which disrupts normal lung developmental processes, including microvascular maturation and alveolarization. Factors that regulate these developmental processes include vascular endothelial growth factor and matrix metalloproteinases, both of which are influenced by generation of oxygen byproducts, or reactive oxygen species (ROS). Read More

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November 2018

Concomitant Arthroscopy With Labral Reconstruction and Periacetabular Osteotomy for Hip Dysplasia.

Arthrosc Tech 2018 Nov 15;7(11):e1141-e1147. Epub 2018 Oct 15.

American Hip Institute, Westmont, Illinois, U.S.A.

In the setting of true hip dysplasia, the high prevalence of intra-articular pathology may lead to recurrent symptoms and failure after periacetabular osteotomy (PAO). Femoral neck osteochondroplasty, microfracture, removal of loose bodies, and labral repair are examples of procedures that are performed with concomitant arthroscopy. When damage to the labrum is too severe to repair, reconstruction instead of extensive debridement before PAO can be more effective in restoring the labral seal to maintain joint lubrication and chondral protection. Read More

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November 2018

Comparison of gene expression in liver regeneration and hepatocellular carcinoma formation.

Cancer Manag Res 2018 15;10:5691-5708. Epub 2018 Nov 15.

College of Life Science, Henan Normal University, Xinxiang, Henan 453007, China,

Background: Liver -cell proliferation occurs in hepatocellular carcinoma (HCC) and liver regeneration (LR). The development and progression of HCC and LR have many similar molecular pathways with very different results. In simple terms, LR is a controllable process of organ recovery and function reconstruction, whereas liver cancer is uncontrollable. Read More

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November 2018
1 Read

Novel Use of Responsive Neurostimulation (RNS System) in the Treatment of Super Refractory Status Epilepticus.

J Clin Neurophysiol 2018 Dec 6. Epub 2018 Dec 6.

Departments of Neurology and.

There are very few randomized controlled trials studying treatment of super refractory status epilepticus (SE), despite estimated occurrence in about 15% of SE cases and its association with high morbidity and mortality rates. Small case series and case reports have described use of neurostimulation, including vagal nerve stimulation, transcranial magnetic stimulation, and deep brain stimulation, to treat super refractory SE when medical interventions have failed. To our knowledge, this is the first reported case of responsive neurostimulation being used to successfully treat a case of super refractory SE. Read More

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December 2018

AQP1 and AQP3 Expression are Associated With Severe Symptoms and Poor-prognosis of the Pancreatic Ductal Adenocarcinoma.

Appl Immunohistochem Mol Morphol 2019 Jan;27(1):40-47

Department of Pathology, Third Xiangya Hospital, Central South University, Changsha, Hunan, China.

Background: Approximately 80% of patients with pancreatic ductal adenocarcinoma (PDAC) have metastatic disease with poor prognosis, but clinically available biomarkers for the diagnosis, prediction of prognosis, and target therapy have not yet been identified.

Objective: To investigate the expression of aquaporin-1 (AQP1) and AQP3 protein and their clinicopathological significances in PDACs.

Materials And Method: AQP1 and AQP3 protein expression in 106 PDAC, 35 peritumoral tissues, 55 benign pancreatic lesions, and 13 normal pancreatic tissues was measured by immunohistochemistry. Read More

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January 2019

[Function of synaptic vesicle protein 2A (SV2A) as a novel therapeutic target for epilepsy].

Nihon Yakurigaku Zasshi 2018 ;152(6):275-280

Department of Pharmacology, Osaka University of Pharmaceutical Sciences.

Epilepsy is a chronic neurologic disease characterized by recurrent seizures, affecting nearly 1% of the population. Synaptic vesicle protein 2A (SV2A) is a membrane protein specifically expressed in synaptic vesicles and is now implicated in the pathogenesis of epileptic disorders. This is because 1) Sv2a-knockout mice exhibit severe seizures, 2) SV2A serves as a specific binding site for certain antiepileptics (e. Read More

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January 2018

Rasmussen syndrome: an atypical presentation in ten patients.

Epileptic Disord 2018 Dec 10. Epub 2018 Dec 10.

Department of Neurosurgery, Hospital de Pediatría "Prof Dr Juan P Garrahan", Buenos Aires, Argentina.

The aim of this study was to analyse the electroclinical and imaging findings and outcome of patients with Rasmussen syndrome (RS) with atypical manifestations. We conducted a retrospective, descriptive study of 10 of 44 consecutive patients with RS with atypical features, followed between 1999 and 2017. Six patients were boys and four were girls. Read More

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December 2018
2 Reads

Age-dependent semiology of frontal lobe seizures.

Epilepsy Res 2018 Oct 23;149:83-87. Epub 2018 Oct 23.

Epilepsy Center, University Medical Center, University of Freiburg, Germany; Faculty of Medicine, University of Freiburg, Germany. Electronic address:

Introduction: Frontal lobe epilepsy is the second most frequent origin of focal epilepsy. Various studies have discussed localizing aspects of ictal signs in frontal lobe epilepsy; the effect of age on semiological manifestations has, however, not been analyzed so far.

Material And Methods: We retrospectively analyzed video-documented semiological signs in a cohort of 122 consecutive patients aged 0-70 years (mean age: 24. Read More

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October 2018
1 Read

No Association Between Pseudopolyps and Colorectal Neoplasia in Patients With Inflammatory Bowel Diseases.

Gastroenterology 2018 Dec 6. Epub 2018 Dec 6.

Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Electronic address:

Background & Aims: Patients with inflammatory bowel diseases (IBD) who have post-inflammatory polyps (PIPs) have an increased risk of colorectal neoplasia (CRN). European guidelines propose that patients with PIPs receive more frequent surveillance colonoscopies, despite limited evidence of this increased risk. We aimed to define the risk of CRN and colectomy in patients with IBD and PIPs. Read More

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December 2018

Dental and Maxillofacial Signs in Leri-Weill Dyschondrosteosis.

J Oral Maxillofac Surg 2018 Nov 12. Epub 2018 Nov 12.

Professor and Department Head, INSERM U1008, Controlled Drug Delivery Systems and Biomaterials, Lille; Université Lille 2 Droit et Santé, Lille; Oral and Maxillofacial Department, Roger Salengro Hospital, CHU Lille, Lille, France.

One of the most common causes of short stature is a defect of the short stature homeobox-containing (SHOX) gene, which is located in pseudoautosomal region 1 on the distal end of the short arm of chromosomes Xp22.33 and Yp11.32. Read More

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November 2018
1 Read

Persistent intestinal metaplasia after endoscopic eradication therapy of neoplastic Barrett's esophagus increases the risk of dysplasia recurrence: meta-analysis.

Gastrointest Endosc 2018 Dec 7. Epub 2018 Dec 7.

Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester. Electronic address:

Background And Aims: Endoscopic eradication therapy (EET) is the main treatment for dysplastic Barrett's esophagus and intramucosal adenocarcinoma. Although the goal of EET is to achieve complete remission of intestinal metaplasia (CRIM), treatment might achieve complete remission of dysplasia (CR-D) only, without achieving CRIM. Persistent intestinal metaplasia after eradication of dysplasia might carry a higher risk for progression into advanced neoplasia. Read More

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December 2018

Glucocorticoid-activation system mediated glucocorticoid-insulin-like growth factor 1 (GC-IGF1) axis programming alteration of adrenal dysfunction induced by prenatal caffeine exposure.

Toxicol Lett 2018 Dec 6. Epub 2018 Dec 6.

Department of Pharmacology, Basic Medical School of Wuhan University, Wuhan 430071, China; Hubei Provincial Key Laboratory of Developmentally Originated Disorder, Wuhan 430071, China. Electronic address:

Glucocorticoids play a major factor in fetal maturation and fate decision after birth. We have previously demonstrated that prenatal caffeine exposure (PCE) resulted in adrenal dysplasia. However, its molecular mechanism has not been clarified. Read More

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December 2018

Current epidemiology and antenatal presentation of posterior urethral valves: Outcome of BAPS CASS National Audit.

J Pediatr Surg 2018 Nov 7. Epub 2018 Nov 7.

Department of Paediatric Urology, Birmingham Children's Hospital, UK. Electronic address:

Aim: Posterior urethral valves (PUVs) are the most common cause of congenital bladder outlet obstruction (BOO) in boys and end-stage renal failure (ESRF) in childhood. In the 1980s, 1 in 4000 boys had PUV. Presentation was 1/3 antenatal/neonatally, 1/3 postnatal, 1/3 late (>1 year). Read More

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November 2018

Scedosporium apiospermum invasive sinusitis presenting as extradural abscess.

Eur Ann Otorhinolaryngol Head Neck Dis 2018 Dec 4. Epub 2018 Dec 4.

Département d'otorhinolaryngologie/chirurgie cervico-faciale/chirurgie de la base du crâne, université Paris-Diderot, hôpital Lariboisière, AP-HP, Paris, France.

Introduction: Chronic invasive fungal rhinosinusitis (CIFR) is a rare entity generally observed in immunodepressed subjects. The pathogen most frequently identified is Aspergillus spp. Imaging generally reveals invasive pseudoneoplastic features. Read More

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December 2018

Total Hip Arthroplasty Reduces Pain and Improves Function in Patients With Spondyloepiphyseal Dysplasia: A Long-Term Outcome Study of 50 Cases.

J Arthroplasty 2018 Oct 30. Epub 2018 Oct 30.

Department of Orthopedic Surgery, Mayo Clinic, Rochester, MN.

Background: Spondyloepiphyseal dysplasia (SED) is rare genetic condition which leads to skeletal and joint deformities that can predispose patients to degenerative joint disease. There are limited reports on the results of total hip arthroplasty (THA) in this patient population. The purpose of this study is to review clinical and radiographic outcomes of THA performed in patients with SED at one institution. Read More

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October 2018

Pregnancy induced hypertension and outcomes in early and moderate preterm infants.

Pregnancy Hypertens 2018 Oct 9;14:68-71. Epub 2018 Aug 9.

Division of Neonatology, Children's Hospital of Fudan University, Shanghai, China. Electronic address:

Objective: To identify the effect of pregnancy induced hypertension on neonatal outcomes in early and moderate preterm infants of gestational age less than 34 weeks.

Study Design: Prospectively collected data in 773 premature deliveries less than 34 weeks from 10 centers in China between July 2014 and July 2016 were analyzed in this cohort study. Univariate and Multivariate regression analyses were conducted to exam the effect of pregnancy induced hypertension on neonatal outcomes, including mortality to discharge, intrauterine growth restriction, severe brain injury, neonatal respiratory distress syndrome, bronchopulmonary dysplasia, necrotizing enterocolitis, early onset of sepsis and retinopathy of prematurity. Read More

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October 2018
2 Reads

Conservation analysis and pathogenicity prediction of mutant genes of ectodysplasin a.

BMC Med Genet 2018 Dec 7;19(1):209. Epub 2018 Dec 7.

Department of Prosthodontics, Changsha Stomatological Hospital, Changsha, 410004, Hunan, China.

Background: Hypohidrotic ectodermal dysplasia (HED) is a common recessive X-linked hereditary disease that affects the development of ectoderm. Gene mutations of ectodysplasin A (EDA) play key roles in process of this disease. In our preliminary study, three unknown mutation sites (c. Read More

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December 2018

Three-year perinatal outcomes of less invasive beractant administration in preterm infants with respiratory distress syndrome.

J Matern Fetal Neonatal Med 2018 Dec 9:1-171. Epub 2018 Dec 9.

a Neonatology Department , Hospital Universitario Gregorio Marañón , Biomedical Research Institute Gregorio Marañón , Complutense University of Madrid , Madrid , Spain.

Objective: To assess the impact of beractant treatment using the less invasive surfactant administration (LISA) technique on perinatal outcomes in a prospective cohort of preterm infants with respiratory distress syndrome (RDS). RDS Design: Single-center prospective study conducted in a Department of Neonatology of a tertiary care university-affiliated hospital in Madrid, Spain.

Methods: Preterm infants born at < 31 + 6 weeks' gestation attended in the neonatal intensive care unit (NICU) between 2012 and 2016. Read More

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December 2018

Suggestion for new 4.4 mm pubo-femoral distance cut-off value for hip instability in lateral position during DDH screening.

Acta Orthop 2018 Dec 10:1-8. Epub 2018 Dec 10.

a Department of Children's Orthopaedics , Aarhus University Hospital , Aarhus.

Background and purpose - Current selective screening algorithms for developmental dysplasia of the hip (DDH) are insufficient. Universal screening programs have been proposed but so far have been deemed too expensive and time consuming. The pubo-femoral distance may solve this problem as a quick, low-cost, highly sensitive, and specific sonographic measurement for DDH, but this has only been validated in the supine position. Read More

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December 2018

Outcomes of Treating Early Glottic Neoplasms With a Potassium Titanyl Phosphate Laser.

Ann Otol Rhinol Laryngol 2018 Dec 11:3489418806914. Epub 2018 Dec 11.

2 Auckland City Hospital, Auckland, New Zealand.

Objectives:: The aim of this study was to assess the outcome of treating glottic dysplasia and early squamous cell carcinoma (SCC) with potassium titanyl phosphate (KTP) photoangiolytic laser ablation.

Methods:: Patient demographics, comorbidities, and tumor characteristics were recorded. Perceptual, patient-reported, and objective voice outcomes were assessed. Read More

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December 2018
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Long-term seizure outcome in frontal lobe epilepsy surgery.

Epilepsy Behav 2018 Dec 3;90:93-98. Epub 2018 Dec 3.

IRCCS "NEUROMED", Pozzilli, IS, Italy; Department of Neurology and Psychiatry, "Sapienza" University of Rome, Italy.

Purpose: The purpose of this study was to report long-term seizure outcome in patients who underwent frontal lobe epilepsy (FLE) surgery.

Method: This retrospective study included 44 consecutive subjects who underwent resective surgery for intractable FLE at IRCCS NEUROMED (period 2001-2014), followed up for at least 2 years (mean: 8.7 years). Read More

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December 2018
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[Morbidity in Prematurity Associated with Fetal Growth Restriction: Experience of a Tertiary Care Center].

Acta Med Port 2018 Nov 30;31(11):648-655. Epub 2018 Nov 30.

Serviço de Neonatologia. Departamento de Pediatria. Hospital Universitário de Santa Maria. Centro Hospitalar Lisboa Norte. Lisboa. Clínica Universitária de Pediatria. Faculdade de Medicina. Universidade de Lisboa. Lisboa. Portugal.

Introduction: Prematurity and low birth weight have been associated with increased neonatal morbidity and mortality. This study aimed to evaluate possible risk factors for prematurity associated with fetal growth restriction and being small for gestational age and to determine the incidence of morbidity in these two groups of infants.

Material And Methods: Retrospective case-control study of newborns with gestational age of less than 32 weeks, with obstetric diagnosis of fetal growth restriction and with the clinical diagnosis of small for gestational age, admitted to the Neonatal Intensive Care Unit of a tertiary hospital for a period of six years. Read More

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November 2018