63,750 results match your criteria Dysphagia


Relationship Between Body Mass Index and Rehabilitation Outcomes in Subacute Stroke with Dysphagia.

Am J Phys Med Rehabil 2019 Feb 12. Epub 2019 Feb 12.

Clinical Laboratory of Experimental Neurorehabilitation, IRCCS Santa Lucia Foundation. Via Ardeatina, 306 - 00179. Rome, Italy.

Objective: To investigate the association between body mass index (BMI) and rehabilitation outcome in hemiparetic patients with stroke in subacute phase.

Design: This was a prospective study testing the correlation between BMI and the effectiveness of rehabilitation, measured using Barthel Index (BI) scores. We enrolled patients with subacute stroke (n=664, age 68±14 years, length of hospital stay 84±34 days). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/PHM.0000000000001159DOI Listing
February 2019

Clinical features of thirty-two patients with anti-melanoma differentiation-associated gene 5 antibodies.

Clin Exp Rheumatol 2019 Feb 11. Epub 2019 Feb 11.

Department of Rheumatology and Immunology of the Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Objectives: To investigate the clinical characteristics of patients positive for anti-melanoma differentiation-associated gene 5 (MDA5) antibodies, and to analyse the potential pathogenesis of anti-MDA5 antibodies.

Methods: The clinical manifestations, serological tests, imaging features, treatments, and prognoses of 32 anti-MDA5 antibody-positive patients diagnosed in the Rheumatology and Immunology Department of the Second Affiliated Hospital of Chongqing Medical University from September 2015 to August 2018 were analysed.

Results: Of the 32 anti-MDA5 antibody-positive patients, eleven patients were clinically diagnosed with interstitial pneumonia with autoimmune features (IPAF), ten patients were diagnosed with clinically amyopathic dermatomyositis (CADM), six patients were diagnosed with dermatomyositis (DM) and five patients were diagnosed with anti-synthetase syndrome (ASS). Read More

View Article

Download full-text PDF

Source
February 2019

Simultaneous Radiological and Fiberendoscopic Evaluation of Swallowing ("SIRFES") in Patients After Surgery of Oropharyngeal/Laryngeal Cancer and Postoperative Dysphagia.

Dysphagia 2019 Feb 14. Epub 2019 Feb 14.

Division of Phoniatrics-Logopedics, Department of Otorhinolaryngology, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria.

To compare the results of a simultaneously performed videofluoroscopic swallowing study and fiberendoscopic evaluation of swallowing in patients with dysphagia after surgery and radiotherapy for oropharyngeal or laryngeal cancer. This prospective study included 31 patients who were examined simultaneously with a standardized protocol. The fiberendoscopic and videofluoroscopic swallowing loops were independently scored by two otorhinolaryngologists/phoniatricians and two radiologists. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00455-019-09979-8DOI Listing
February 2019

Congenital myasthenic syndrome caused by novel COL13A1 mutations.

J Neurol 2019 Feb 14. Epub 2019 Feb 14.

Department of Neurology, Friedrich-Baur-Institute, University Hospital, LMU Munich, Marchioninistrasse 17, 81377, Munich, Germany.

Collagen XIII is a non-fibrillar transmembrane collagen which has been long recognized for its critical role in synaptic maturation of the neuromuscular junction. More recently, biallelic COL13A1 loss-of-function mutations were identified in three patients with congenital myasthenic syndrome (CMS), a rare inherited condition with defective neuromuscular transmission, causing abnormal fatigability and fluctuating muscle weakness and often successfully treated with acetylcholinesterase inhibitors. Here we report six additional CMS patients from three unrelated families with previously unreported homozygous COL13A1 loss-of-function mutations (p. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00415-019-09239-7DOI Listing
February 2019

Management of Zenker's diverticulum using flexible endoscopy.

VideoGIE 2019 Feb 30;4(2):87-90. Epub 2019 Jan 30.

Department of Surgery, St George Hospital, Sydney, New South Wales, Australia.

Background And Aims: Zenker's diverticulum is a false diverticulum through Killian's dehiscence. Symptoms include halitosis, dysphagia, regurgitation, cough, and aspiration pneumonia. Treatment options include open transcervical cricopharyngeal myotomy, trans-oral rigid endoscopic stapling, and minimally invasive endoscopic myotomy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.vgie.2018.12.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363821PMC
February 2019
1 Read

Lung adenocarcinoma and anti-transcriptional intermediary factor 1-gamma positive dermatomyositis complicated with spontaneous oesophageal rupture.

Respirol Case Rep 2019 Apr 4;7(3):e00403. Epub 2019 Feb 4.

Department of Respiratory Medicine Kyorin University School of Medicine Tokyo Japan.

A 58-year-old man presented with a two-month history of facial erythema and dry cough. Physical examination revealed typical cutaneous manifestations of dermatomyositis (DM), including heliotrope rash and shawl sign. A chest X-ray revealed a 4-cm mass in the right middle lung. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/rcr2.403DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360367PMC

Feeding difficulties in infants with unrepaired cleft lip and palate and HIV-exposure.

Afr Health Sci 2018 Dec;18(4):1098-1108

Department of Speech-Language Pathology and Audiology, Faculty of Humanities, University of Pretoria Private Bag X20, Hatfield 0028.

Background: There is limited description of the feeding characteristics of infants with unrepaired cleft lip and palate, exposed to HIV, but not necessarily infected.

Objective: To compare the feeding characteristics of infants with unrepaired cleft lip and palate and HIV-exposure, to infants with unrepaired cleft lip and palate only.

Method: A two-group comparative design with a validated measure, the Neonatal Feeding Assessment Scale was used. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4314/ahs.v18i4.31DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354895PMC
December 2018

Desmin and dystrophin abnormalities in upper airway muscles of snorers and patients with sleep apnea.

Respir Res 2019 Feb 14;20(1):31. Epub 2019 Feb 14.

Department of Integrative Medical Biology, Laboratory of Muscle Biology, Umeå University, SE-901 87, Umeå, Sweden.

Background: The pathophysiology of obstruction and swallowing dysfunction in snores and sleep apnea patients remains unclear. Neuropathy and to some extent myopathy have been suggested as contributing causes. Recently we reported an absence and an abnormal isoform of two cytoskeletal proteins, desmin, and dystrophin, in upper airway muscles of healthy humans. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12931-019-0999-9DOI Listing
February 2019

Primary Esophageal Diffuse Large B-Cell Lymphoma: A Comparative Review of 15 Cases.

J Investig Med High Impact Case Rep 2018 Jan-Dec;6:2324709618820887

5 Abington - Jefferson Health, Abington, PA, USA.

Primary esophageal diffuse large B-cell lymphoma (DLBCL) is an extremely rare clinicopathologic entity. We report one case from our clinical experience and undertake a review of the previously published cases. A systematic literature search of the medical databases PubMed and Google Scholar was conducted. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/2324709618820887DOI Listing
February 2019

[Laryngeal Tuberculosis Diagnosed in a Pathological Laboratory in Senegal (2011-2015)].

Bull Soc Pathol Exot 2018 ;111(1):5-8

Laboratoire d'anatomie et cytologie pathologiques, de l'hôpital Aristide-Le-Dantec, Dakar, Sénégal.

Laryngeal tuberculosis (LT) is a rare disease. The therapy for LT is easy but the diagnosis remains a challenge for the pathologist and the laryngologist because of the absence of specific signs. The objective was to analyze the epidemiological and pathological profiles of LT cases in Dakar (Senegal) with a view to better understand this pathology. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3166/bspe-2018-0010DOI Listing
January 2018

Solitary nasopharynx metastasis from hepatocellular carcinoma after liver transplantation: A case report.

Medicine (Baltimore) 2019 Feb;98(7):e14368

Rationale: Hepatocellular carcinoma (HCC) is the fifth most common cancer and third leading cause of cancer-related deaths worldwide. Nasopharyngeal metastasis of hepatocellular carcinoma is very rare. This is the first report of posttransplantation nasopharyngeal metastasis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MD.0000000000014368DOI Listing
February 2019

Stroke Severity Versus Dysphagia Screen as Driver for Post-stroke Pneumonia.

Front Neurol 2019 29;10:16. Epub 2019 Jan 29.

Stroke and Ageing Research (STARC), Department of Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, VIC, Australia.

Post-stroke pneumonia is a feared complication of stroke as it is associated with greater mortality and disability than in those without pneumonia. Patients are often kept "Nil By Mouth" (NBM) after stroke until after receiving a screen for dysphagia and declared safe to resume oral intake. We aimed to assess the proportional contribution of stroke severity and dysphagia screen to pneumonia by borrowing idea from coalition game theory on fair distribution of marginal profit (Shapley value). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fneur.2019.00016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361825PMC
January 2019

Primary malignant melanoma of esophagus: clinicopathologic characterization of 20 cases including molecular genetic profiling of 15 tumors.

Mod Pathol 2019 Feb 13. Epub 2019 Feb 13.

Laboratory of Pathology, National Cancer Institute, National Institute of Health, Bethesda, MD, USA.

Primary malignant melanoma of esophagus is very rare, and its clinicopathologic and genetic features have not been extensively investigated. In this study, 20 tumors from 14 male and 6 female patients (40-79 years old) were evaluated. Dysphagia, chest pain, and weight loss were frequent symptoms. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41379-018-0163-yDOI Listing
February 2019

[The effectiveness of the complete lateral position method in elderly patients with severe dysphagia].

Nihon Ronen Igakkai Zasshi 2019 ;56(1):59-66

Department of Surgery, Hida City Hospital.

Aim: This study aimed to clarify the effectiveness of using the complete lateral position method to treat elderly patients with severe dysphagia.

Methods: We enrolled 47 patients >65 years of age who had been diagnosed with severe dysphagia using a video endoscopic examination of swallowing at Hida City Hospital between February 1, 2015, and October 31, 2017. We collected and analyzed data pertaining to patient characteristics, the onset of aspiration pneumonia, and treatment outcomes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3143/geriatrics.56.59DOI Listing
January 2019

Unexpected Complication of a Multinodular Goitre.

Eur J Case Rep Intern Med 2016 22;3(2):000363. Epub 2016 Jan 22.

Department of Endocrinology, Rijnstate Hospital Arnhem, Arnhem, The Netherlands.

Multinodular goitre is the most common thyroid gland disorder. It can cause hyperthyroidism and mechanical complaints such as tracheal compression or dysphagia. We report a unique case of a patient with a toxic multinodular goitre presenting with a deep venous thrombosis of the left arm due to direct local compression of blood flow. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.12890/2016_000363DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346951PMC
January 2016

Polymyositis and the Spectrum of Scleroderma Disorders.

Eur J Case Rep Intern Med 2016 22;3(1):000346. Epub 2015 Dec 22.

Internal Medicine Department, Coimbra Hospital and Universitary Centre, Coimbra, Portugal.

Polymyositis (PM) is usually associated to other autoimmune or connective tissue diseases. The authors report the case of a 59-year-old man with pulmonary fibrosis, who presented with constitutional symptoms and gradually developed proximal muscle weakness, Raynaud phenomenon, and dysphagia. Besides creatine kinase (CK) elevation, he had positive anti-Polymyositis-Scleromyositis (PM-Scl) and anti-Sjögren's-syndrome A (SSA) antibodies. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.12890/2015_000346DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346825PMC
December 2015

Anterior Dor or Posterior Toupet with Heller Myotomy for Achalasia Cardia: A Systematic Review and Meta-Analysis.

World J Surg 2019 Feb 12. Epub 2019 Feb 12.

Mayne Medical School, School of Medicine, University of Queensland, Brisbane, QLD, Australia.

Background And Aims: Partial fundoplication is commonly performed in conjunction with Heller Myotomy. It is, however, controversial whether anterior Dor or posterior Toupet partial fundoplication is the antireflux procedure of choice. The aim was to perform a systematic review and meta-analysis of studies comparing these two procedures. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00268-019-04945-9DOI Listing
February 2019

Delayed Diagnosis of Atypical Presentation of Myasthenia Gravis.

Eur J Case Rep Intern Med 2018 22;5(2):000785. Epub 2018 Feb 22.

Internal Medicine Department, St. Luke General Hospital, Kilkenny, Ireland.

Myasthenia gravis is an autoimmune disorder affecting the neuromuscular junction, resulting in muscle fatiguability and weakness. The pathological characteristics of the disorder include ocular weakness resulting in diplopia and/or ptosis. More generally, the disease can result in fluctuant weakness of skeletal muscle, predominantly affecting ocular, bulbar and respiratory muscles. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.12890/2017_000785DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346934PMC
February 2018

A Novel Mutation in the Adult-Onset Alexander's Disease Gene.

Case Rep Med 2019 10;2019:2986538. Epub 2019 Jan 10.

Brookwood Baptist Health Medical Education, 817 Princeton Ave SW, POB2, Suite 106, Birmingham, AL 35211, USA.

The case describes a 25-year-old Caucasian female diagnosed with Alexander's disease (AxD) as an outpatient after extensive inpatient workup. Her presenting complaints included incontinence, clumsiness, seizures, dysphagia, and dysarthria. She was also found to have pancytopenia and dysautonomia. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1155/2019/2986538DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348877PMC
January 2019

Eosinophilic esophagitis and achalasia - just a coincidence?

Z Gastroenterol 2019 Feb 12;57(2):151-155. Epub 2019 Feb 12.

Medizinische Klinik II, HELIOS Klinikum Krefeld, Germany.

Background:  Eosinophilic esophagitis (EoE) is detected frequently in dysphagia and noncardiac chest pain. Management of patients with EoE may be complicated because EoE is associated frequently with esophageal motility disorders. We present the rare case of esophageal achalasia (EA) associated with eosinophilic infiltration and a literature review. Read More

View Article

Download full-text PDF

Source
http://www.thieme-connect.de/DOI/DOI?10.1055/a-0808-5043
Publisher Site
http://dx.doi.org/10.1055/a-0808-5043DOI Listing
February 2019

Neonatal vocal fold motion impairment after complex aortic arch reconstruction: What should parents expect after diagnosis?

Int J Pediatr Otorhinolaryngol 2019 Feb 5;120:40-43. Epub 2019 Feb 5.

University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States.

Objectives: To study the incidence, sequelae, follow up, and recovery rate of vocal fold motion impairment (VFMI) after complex aortic arch reconstruction in neonates.

Study Design: Retrospective case control study.

Methods: We retrospectively evaluated 105 neonates who underwent complex aortic arch reconstruction from 2014 to 2016. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijporl.2019.02.006DOI Listing
February 2019

Recurrent oral squamous cell carcinoma-incorporating advance care planning in education and practice.

Spec Care Dentist 2019 Feb 12. Epub 2019 Feb 12.

Department of Nursing, Michigan Medicine, Ann Arbor, Michigan.

This reflection describes a life-limiting case of oral squamous cell carcinoma (SCC) that required thoughtful management facilitated by an advance care plan (ACP). A 70-year-old female was diagnosed with a T4aN2bM0 biopsy-proven invasive, well-differentiated keratinizing SCC. Surgical wide-local excision included teeth #11-16 with left unilateral neck dissection, levels I-V. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/scd.12369DOI Listing
February 2019

Redo Surgery after Failure of Antireflux Surgery.

Am Surg 2018 Nov;84(11):1819-1824

Surgery for refractory gastroesophageal reflux disease (GERD) has a satisfactory outcome for most patients; however, sometimes redo surgery is required. The Outcome and morbidity of a redo are suggested to be less successful than those of primary surgery. The aim of this study was to describe our experience, long-term results, and complications in redo surgery. Read More

View Article

Download full-text PDF

Source
November 2018
1 Read

The Use of Rigiflex Pneumatic Balloon Dilator during Laparoscopic Heller's Myotomy in Patients with Achalasia: A Novel Technical Method and Its Surgical Outcomes.

Am Surg 2018 Nov;84(11):1796-1800

Pneumatic balloon dilatation (BD) and laparoscopic Heller's myotomy (LHM) are usually preferred treatment options for relieving dysphagia symptoms in achalasia. The aim of the present study was to describe a new technical method for a safe and effective LHM. Endoscopic BD tube (Rigiflex 30-mm pneumatic balloon) is simultaneously insufflated and desufflated in the esophagus during LHM to assess myotomy in 50 consecutive patients. Read More

View Article

Download full-text PDF

Source
November 2018

Relationship between jaw-opening force and neck circumference in healthy older individuals.

Geriatr Gerontol Int 2019 Feb 12. Epub 2019 Feb 12.

Division of Gerontology and Gerodontology, Department of Gerodontology, Tokyo Medical and Dental University, Tokyo, Japan.

Aim: In recent years, the relationships of arm circumference and calf circumference with swallowing function have been reported. However, the efficacy of using the neck circumference, which is closer to the swallowing-related muscles, has never been verified. Jaw-opening force, an indicator of suprahyoid muscle strength, is known to be useful for screening for dysphagia. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/ggi.13620DOI Listing
February 2019

Challenges to assumptions regarding oral shear rate during oral processing and swallowing based on sensory testing with thickened liquids.

Food Hydrocoll 2018 Nov 23;84:173-180. Epub 2018 May 23.

Department of Food Science, University of Guelph, 50 Stone Road East, Guelph, ON N1G 2W1, Canada.

For people with dysphagia, or difficulty swallowing, thickened liquids are used to slow bolus flow to make them easier to control. For these liquids, the oral shear rate of 50 s has been adopted as the standard at which viscosity measurements are taken. However, there is evidence to suggest that other shear rates may be more appropriate to model the processes in the mouth and throat. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.foodhyd.2018.05.043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367734PMC
November 2018

Selected ENT symptoms in functional disorders of the upper cervical spine and temporomandibular joints.

HNO 2019 Feb 11. Epub 2019 Feb 11.

HNO Universitätsklinikum Magdeburg, Magdeburg, Germany.

This paper discusses otorhinolaryngological symptoms associated with functional disorders of the upper cervical spine. Hints aimed to avoid misdiagnoses of cross-organ otorhinolaryngological symptoms as phobic or psychogenic disorders are presented. Clinically relevant neuroanatomical convergence of the upper cervical spine (occiput to C3) is fundamental for the interpretation of functional otorhinolaryngological symptoms. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00106-019-0610-1DOI Listing
February 2019

Development and Validation of a Prognostic Model of Swallowing Recovery and Enteral Tube Feeding After Ischemic Stroke.

JAMA Neurol 2019 Feb 11. Epub 2019 Feb 11.

Department of Neurology, Kantonsspital St Gallen, St Gallen, Switzerland.

Importance: Predicting the duration of poststroke dysphagia is important to guide therapeutic decisions. Guidelines recommend nasogastric tube (NGT) feeding if swallowing impairment persists for 7 days or longer and percutaneous endoscopic gastrostomy (PEG) placement if dysphagia does not recover within 30 days, but, to our knowledge, a systematic prediction method does not exist.

Objective: To develop and validate a prognostic model predicting swallowing recovery and the need for enteral tube feeding. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1001/jamaneurol.2018.4858DOI Listing
February 2019
1 Read

Optimising Radiation Therapy Dose to the Swallowing Organs at Risk: An In Silico Study of feasibility for Patients with Oropharyngeal Tumours.

Dysphagia 2019 Feb 11. Epub 2019 Feb 11.

Radiation Oncology, Nelune Comprehensive Cancer Centre, POWH, Sydney, NSW, 2031, Australia.

Recent evidence suggests that reducing radiotherapy dose delivered to specific anatomical swallowing structures [Swallowing Organs at Risk (SWOARs)] may improve swallowing outcomes post-treatment for patients with head and neck cancer. However, for those patients with tumours of the oropharynx, which typically directly overlap the SWOARs, reducing dose to these structures may be unachievable without compromising on the treatment of the disease. To assess the feasibility of dose reduction in this cohort, standard IMRT plans (ST-IMRT) and plans with reduced dose to the SWOARs (SW-IMRT) were generated for 25 oropharyngeal cancer patients (Brouwer et al. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00455-019-09983-yDOI Listing
February 2019
1 Read

Neuromuscular electrical stimulation for treatment of dysphagia in infants and young children with neurological impairment: a prospective pilot study.

BMJ Paediatr Open 2019 23;3(1):e000382. Epub 2019 Jan 23.

Division of Pediatric Medicine, Department of Paediatrics, University of Toronto, Toronto, Ontario, Canada.

Objectives: To describe the acceptability, safety and effectiveness of neuromuscular electrical stimulation (NMES) in infants and young children with neurological impairment (NI) who have severe dysphagia.

Design: A prospective pilot study using a before and after study design.

Setting: The Hospital for Sick Children, Toronto, Canada. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bmjpo-2018-000382DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347906PMC
January 2019

Current strategies of reduce the rate of dysphagia and dysphonia after anterior cervical spine surgery and role of corticosteroids.

Ann Transl Med 2018 Dec;6(Suppl 2):S99

Department of Spine Surgery, Zhejiang Spine Surgery Centre, Orthopaedic Hospital, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, The Second School of Medicine Wenzhou Medical University, the Key Laboratory of Orthopaedics of Zhejiang Province, Wenzhou 325027, China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.21037/atm.2018.11.29DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330607PMC
December 2018

Phase Ib evaluation of a self-adjuvanted protamine formulated mRNA-based active cancer immunotherapy, BI1361849 (CV9202), combined with local radiation treatment in patients with stage IV non-small cell lung cancer.

J Immunother Cancer 2019 Feb 8;7(1):38. Epub 2019 Feb 8.

Medical Oncology, University Hospital Basel, Basel, Switzerland.

Background: Preclinical studies demonstrate synergism between cancer immunotherapy and local radiation, enhancing anti-tumor effects and promoting immune responses. BI1361849 (CV9202) is an active cancer immunotherapeutic comprising protamine-formulated, sequence-optimized mRNA encoding six non-small cell lung cancer (NSCLC)-associated antigens (NY-ESO-1, MAGE-C1, MAGE-C2, survivin, 5T4, and MUC-1), intended to induce targeted immune responses.

Methods: We describe a phase Ib clinical trial evaluating treatment with BI1361849 combined with local radiation in 26 stage IV NSCLC patients with partial response (PR)/stable disease (SD) after standard first-line therapy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s40425-019-0520-5DOI Listing
February 2019
1 Read

Retropharyngeal granulation: A delayed complication of anterior cervical discectomy and fusion in C2-3.

World Neurosurg 2019 Feb 5. Epub 2019 Feb 5.

Department of Neurosurgery, Chonnam National University Hospital and Medical School, Gwangju, Republic of Korea. Electronic address:

Introduction: A 26-year-old man presented with acute quadriparesis owing to a traffic accident. A computed tomography scan revealed a hangman fracture and locking of the left facet joint at C2-3. Magnetic resonance imaging showed a high signal change of the spinal cord on T2-weighted image and hemorrhage in the C2-3 level. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.wneu.2019.01.156DOI Listing
February 2019
1 Read

Associations between Spontaneous Swallowing Frequency at Admission, Dysphagia and Stroke Related Outcomes in Acute Care.

Arch Phys Med Rehabil 2019 Feb 5. Epub 2019 Feb 5.

Swallowing Research Laboratory, University of Central Florida.

Objective: To expand the scope of prior spontaneous swallowing frequency analysis (SFA) studies, by evaluating the role of SFA in dysphagia-and stroke-related outcomes at acute stroke discharge.

Design: Period prevalence study SETTING: Tertiary care university hospital PARTICIPANTS: 96 patients with acute stroke.

Interventions: Subjects were screened for dysphagia using SFA. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.apmr.2019.01.009DOI Listing
February 2019
1 Read

First Experience with Banded Anti-reflux Mucosectomy (ARMS) for GERD: Feasibility, Safety, and Technique (with Video).

J Gastrointest Surg 2019 Feb 7. Epub 2019 Feb 7.

Department of Surgery, NorthShore University HealthSystem, Evanston, IL, USA.

Background: Anti-reflux mucosectomy (ARMS) is a relatively new endoscopic procedure for gastroesophageal reflux disease (GERD). A hemi-circumferential endoscopic mucosal resection (EMR) is performed around the gastroesophageal junction (GEJ), which then contracts and tightens during healing. The aim of this study was to assess the feasibility and safety of the procedure. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11605-019-04115-1DOI Listing
February 2019
2 Reads

Burkitt's Lymphoma of the Gastrohepatic Omentum: A Malignant Presentation of Pseudoachalasia.

Case Rep Gastrointest Med 2019 13;2019:1803036. Epub 2019 Jan 13.

Division of Gastroenterology and Hepatology, SBH Health System, 4422 Third Ave, Bronx, New York 10457, USA.

Achalasia is an intrinsic disorder of the esophagus that results from loss of ganglion cells in the lower esophageal sphincter. Clinically it is manifested by dysphagia to solids and liquids, weight loss, regurgitation, and chest pain. Pseudoachalasia, in contrast, is a rare entity that causes identical symptoms, but has a divergent underlying pathogenesis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1155/2019/1803036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348844PMC
January 2019
1 Read

Pneumonia in hospitalized neurologic patients: trends in pathogen distribution and antibiotic susceptibility.

Antimicrob Resist Infect Control 2019 1;8:25. Epub 2019 Feb 1.

1Department of Neurology, Laboratory for Neurotherapeutics, Biomedical Research Institute, Seoul National University Hospital, 101 Daehak-ro, Jongno-gu, Seoul, 110-744 South Korea.

Background: Bed-ridden state, dysphagia, altered mental state, or respiratory muscle weakness are common in neurologic patients and increase the risk of pneumonia. The major causes of pneumonia in neurologic patients may differ from those in the general population, resulting in a different pathogen distribution. We investigated the trends of pathogen distribution in culture-positive pneumonia in hospitalized neurologic patients and the related antibiotic resistance in those with hospital-acquired pneumonia (HAP). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13756-019-0475-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359823PMC
February 2019
1 Read

Intramural oesophageal abscess: an unusual complication of tonsillitis.

BMJ Case Rep 2019 Feb 6;12(2). Epub 2019 Feb 6.

Department of General Surgery, University Hospital Crosshouse, Kilmarnock, Scotland.

Tonsillitis is an extremely common condition, usually it is self-limiting, of viral origin, and managed conservatively in general practice. Rarely patients require inpatient management, usually when bacterial infection is present or when the cause is virulent organisms such as Epstein Barr virus. Complications can be divided into non-suppurative; sepsis, scarlet fever, rheumatic fever, glomerulonephritis and Lemierres disease, and suppurative; quinsy, parapharyngeal abscess and retropharyngeal abscess, respectively. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bcr-2018-226010DOI Listing
February 2019
1 Read

Self-expandable metal stent for dysphagia caused by mediastinal masses in patients with lung cancer.

Arab J Gastroenterol 2019 Feb 4. Epub 2019 Feb 4.

Endoscopy Unit, Department of Gastroenterology and Hepatology, University Hospital Centre Zagreb, Croatia.

Background And Study Aims: We intended to evaluate the role of self-expandable metal stents (SEMS) for palliation of malignant dysphagia in patients with lung cancer.

Patients And Methods: During the period between May 2015 and September 2017, 42 SEMS have been placed for malignant dysphagia in patients with lung cancer. Stents have been placed under combined fluoroscopic and endoscopic guidance. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ajg.2019.01.004DOI Listing
February 2019
1 Read

Impact of carbonation on neurogenic dysphagia and an exploration of the clinical predictors of a response to carbonation.

Int J Lang Commun Disord 2019 Feb 7. Epub 2019 Feb 7.

The University of Queensland, School of Health & Rehabilitation Sciences, St Lucia, QLD, Australia.

Background: The need for effective compensatory strategies in neurogenic dysphagia management has led to the exploration of sensory enhancement strategies (SES), such as carbonated liquids. Despite some positive findings, evidence related to the efficacy of carbonation as an SES is limited.

Aims: To determine if carbonated thin liquids reduced dysphagia symptoms and to explore clinical factors associated with response to carbonation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/1460-6984.12458DOI Listing
February 2019

Screening and evaluation tools of dysphagia in adults with neuromuscular diseases: a systematic review.

Ther Adv Chronic Dis 2019 31;10:2040622318821622. Epub 2019 Jan 31.

Institut de Recherche Expérimentale et Clinique (IREC), Pôle de Pneumologie, ORL & Dermatologie, Université Catholique de Louvain, Brussels, Belgium.

Background: The purpose of this systematic review was to summarize the different dysphagia screening and evaluation tools, and to identify their measurement properties in adults with neuromuscular diseases (NMDs).

Methods: A systematic review was performed based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The search strategy was conducted across three databases ( and ). Read More

View Article

Download full-text PDF

Source
http://journals.sagepub.com/doi/10.1177/2040622318821622
Publisher Site
http://dx.doi.org/10.1177/2040622318821622DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357297PMC
January 2019
3 Reads

Variations in the Clinical Course of Patients with Herpes Simplex Virus Esophagitis Based on Immunocompetence and Presence of Underlying Esophageal Disease.

Dig Dis Sci 2019 Feb 6. Epub 2019 Feb 6.

Division of Gastroenterology and Hepatology, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.

Background And Aims: Herpes simplex esophagitis (HSE) is the second most common cause of infectious esophagitis and occurs in both immunocompetent and immunocompromised patients. The aim of this study was to reappraise the clinical course of HSE in different patient populations based on degree of immunocompetence and the presence or absence of underlying esophageal disease.

Methods: Patients with histopathologically confirmed HSE identified from the Mayo Clinic pathology database from 2006 to 2016 were included in this study. Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s10620-019-05493-x
Publisher Site
http://dx.doi.org/10.1007/s10620-019-05493-xDOI Listing
February 2019
3 Reads

[Validation of the eat-10 score to detect dysphagia in older people].

Rev Med Chil 2018 Sep;146(9):1008-1015

Instituto de Nutrición y Tecnología en Alimentos, Universidad de Chile, Santiago, Chile.

Background: In Chile, comprehensive geriatric assessment does not include the identification of dysphagia, despite being considered a geriatric syndrome. The Eating Assessment Tool 10 (EAT-10) questionnaire is a 10-question instrument that specifically describes the perception of dysphagia and has a Spanish translation.

Aim: To validate and test the reliability of the EAT-10 questionnaire in Chilean older people living in the community. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4067/s0034-98872018000901008DOI Listing
September 2018
1 Read

Prevalence and Characteristics Associated with Modified Texture Food Use in Long Term Care: An Analysis of Making the Most of Mealtimes (M3) Project.

Can J Diet Pract Res 2019 02 7:1-7. Epub 2019 Feb 7.

e Toronto Rehabilitation Institute, University Health Network, Toronto, ON.

Purpose: To describe the prevalence and characteristics of modified-texture food (MTF) consumers when applying standard diet terminology.

Methods: Making the Most of Mealtimes (M3) is a cross-sectional multi-site study including 32 long-term care (LTC) homes located in 4 Canadian provinces. Resident characteristics were collected from health records using a defined protocol and extraction form. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3148/cjdpr-2018-045DOI Listing
February 2019
1 Read

Dysphagia optimized radiotherapy to reduce swallowing dysfunction severity in patients undergoing treatment for head and neck cancer: A systematized scoping review.

Head Neck 2019 Feb 5. Epub 2019 Feb 5.

Division of Speech Pathology, School of Health and Rehabilitation Sciences, The University of Queensland, St Lucia, Queensland, Australia.

This study involved a systematized scoping review to coalesce current evidence on dysphagia outcomes achieved through active sparing of the swallowing structures in patients receiving radiotherapy for head and neck cancer. Eligible publications between 2007 and 2017 were reviewed and synthesized regarding participant demographics, treatment regimens, swallowing structures chosen for optimization, dosimetric constraints, and dysphagia measures. Nine prospective cohort studies were included. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/hed.25688DOI Listing
February 2019
1 Read

Heller Myotomy for Epiphrenic Diverticula Compared to Nondiverticula Esophageal Motility Disorders, A Single Institution Experience and Appraisal of Patient Characteristics, High-Resolution Manometry and Outcomes.

Dig Surg 2019 Feb 5:1-9. Epub 2019 Feb 5.

Division of General Surgery, Morsani College of Medicine, University of South Florida, Tampa, Florida,

Purpose: The purpose of this study was to compare demographics, symptoms, prior interventions, operation, and outcomes of patients who underwent Heller myotomy for esophageal motility disorders and epiphrenic diverticulectomy with Heller myotomy.

Methods: We identified all patients who underwent Heller myotomy for esophageal motility disorders with and without esophageal diverticulectomy over an 80-month period. Primary data points included patient demographics, presenting symptoms, prior intervention, high-resolution manometry, surgery performed with rate of laparoscopic, conversion to open, and open procedures; postoperative complications, and symptom resolution. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000496804DOI Listing
February 2019
1 Read