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Obstet Gynecol Sci 2020 May 19;63(3):357-362. Epub 2020 Mar 19.

Department of Obstetrics and Gynecology, Bucheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Objective: To evaluate the clinical and pathological characteristics of lower anterior abdominal wall masses suspicious for endometriosis.

Methods: A retrospective review of 38 patients who underwent surgery for a lower anterior abdominal wall mass suspicious for endometriosis was performed. Those with skin and intraperitoneal masses, lipomas, hernias, and metastatic malignant masses were excluded. Read More

Zhongguo Zhong Yao Za Zhi 2020 Apr;45(8):1933-1941

Affiliated Hospital of Nanjing University of Chinese Medicine Nanjing 210029, China.

To systemically evaluate the efficacy and safety of Kuntai Capsules combined with GnRH-a in the treatment of endome-triosis. The databases of CNKI, WanFang, VIP, PubMed, EMbase and Cochrane Library were searched from their establishment to May 2019 to collect the randomized controlled trials of Kuntai Capsules combined with GnRH-a in the treatment of endometriosis. The data were searched, screened and extracted by two researchers according to the inclusion and exclusion criteria, and the data were analyzed by using RevMan 5. Read More

Perspect Psychiatr Care 2020 Jun 3. Epub 2020 Jun 3.

Nursing Department, Gynecology and Obstetric Nursıng Department, Faculty of Health Sciences, Gazi University, Ankara, Turkey.

Purpose: This study was conducted to define the relationship of experiencing premenstrual syndrome (PMS) and dysmenorrhea with the personality structure of women.

Design And Methods: The sample of this descriptive relation-seeker-type study comprised 353 women. Data were collected using the PMS Scale, Quick Big Five Personality Test, and The Questionnaire Form between 1 April and 31 August 2019 in a city in the Mediterranean region in Turkey. Read More

Hum Reprod 2020 Jun 3. Epub 2020 Jun 3.

Centre for Reproductive Health, The Hudson Institute of Medical Research, 27-31 Wright Street, Clayton 3168, Australia.

Study Question: Does NLRP3 (NOD-, LRR- and pyrin domain-containing protein 3) inflammasome activation within decidualized endometrial stromal cells accompany menstruation and is this reflected systemically?

Summary Answer: Components of the NLRP3 inflammasome immunolocalize to decidualized endometrial stromal cells immediately prior to menstruation, and are activated in an in vitro model of menstruation, as evidenced by downstream interleukin (IL)-1beta and IL-18 release, this being reflected systemically in vivo.

What Is Known Already: Menstruation is a highly inflammatory event associated with activation of NFκB (nuclear factor kappa-light-chain-enhancer of activated B cells), local release of chemokines and cytokines and inflammatory leukocyte influx. Systemically, chemokines and cytokines fluctuate across the menstrual cycle. Read More

Pain Med 2020 Jun 3. Epub 2020 Jun 3.

Department of Obstetrics and Gynecology, NorthShore University HealthSystem & Pritzker School of Medicine, University of Chicago, Chicago, Illinois, USA.

Objective: Incomplete pain relief after administration of nonsteroidal anti-inflammatory drugs (NSAIDs) is common, but it is unknown whether malabsorption or heightened metabolism contributes to NSAID resistance. To explain the etiology of NSAID resistance, we evaluated naproxen absorption and metabolism in relation to pain relief in a pilot study of women with dysmenorrhea.

Methods: During menses, participants completed before and after naproxen ingestion pain assessments. Read More

Medicine (Baltimore) 2020 May;99(22):e20421

Department of Obstetrics and Gynecology.

To evaluate the efficacy and feasibility of levonorgestrel-releasing intrauterine device (LNG-IUD) use longer than 5 years in women with adenomyosis.Data were retrospectively collected from patients who were treated with LNG-IUD longer than 5 years at the Chungnam National University hospital for adenomyosis diagnosed with ultrasonography from January 2006 to November 2013.A total of 131 patients who were diagnosed with adenomyosis had treated with LNG-IUD longer than 5 years. Read More

J Gynecol Obstet Hum Reprod 2020 May 29:101798. Epub 2020 May 29.

Department of Obstetrics and Gynecology, Faculty of Medicine, Cairo University, Cairo, Egypt.

Our objective was to assess and rank different pharmacological interventions for relieving endometriosis-related pain. We conducted an online bibliographic search in different databases from their inception until March 2019. We included randomized controlled trials (RCTs) that assessed different medical therapies in the management of endometriosis-related pain. Read More

J Obstet Gynaecol Can 2020 Apr 4. Epub 2020 Apr 4.

Department of Obstetrics and Gynecology, University of British Columbia, Vancouver, BC.

Objective: Primary dysmenorrhea and provoked vestibulodynia (PVD) are common pain conditions in young women. The purpose of this study was to document the severity of dysmenorrhea in women with confirmed PVD to further clarify reports of comorbidity. Since central sensitisation (CS) of the nervous system is present in both conditions, diagnosis of either, but especially both conditions, may reflect past chronic stress. Read More

J Cancer Res Ther 2020 ;16(2):365-371

Department of Oncology, The Tumor Hospital of Liaocheng, Liaocheng, China.

Aim: This study aims to assess the use of contrast-enhanced ultrasonography (CEUS) and dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) in the evaluation of percutaneous microwave ablation (PMWA) of localized adenomyosis.

Materials And Methods: Sixty-six patients with single-onset adenomyosis who underwent PMWA at the Liaocheng Tumor Hospital of Shandong Province from January 2013 to February 2019 were enrolled. Venous CEUS and DCE-MRI examinations were performed before and 1-2 days after the surgery. Read More

J Minim Invasive Gynecol 2020 May 28. Epub 2020 May 28.

Department of Gynaecological Surgery, Vita Batel Hospital, Curitiba, Brazil.

Objective: The objective of this video is to demonstrate different clinical presentations of peritoneal defects (peritoneal retraction pockets) and their anatomical relationships with the pelvic innervation, justifying the occurrence of some neurological symptoms in association with these disease.

Design: Surgical demonstration of complete excision of different types of peritoneal retraction pockets and a comparison with a laparoscopic retroperitoneal cadaveric dissection of the pelvic innervation.

Setting: Private hospital in Curitiba, Paraná, Brazil. Read More

Clin Diabetes Endocrinol 2020 14;6. Epub 2020 May 14.

Endocrinology Research Centre, 11, ulitsa Dmitriya Ulianova, Moscow, Russian Federation 117036 Russia.

Background: Congenital generalized lipodystrophy (CGL) is a rare disorder characterized by the lack of adipose tissue and metabolic complications with predominantly autosomal recessive inheritance. There are 6 different genes known to cause CGL with 4 main types recognized to date, which differ by the degree of fat loss, association with mental retardation and metabolic disorders, with CGL type 1 and 2 being the most common. Twenty seven cases of СGL type 4 from Japan, Oman, UK, Turkey, Mexico, Saudi Arabia, USA were reported previously. Read More

Int J Surg Case Rep 2020 May 12;71:179-182. Epub 2020 May 12.

Department of Obstetrics and Gynecology, The First Affiliated Hospital of Anhui Medical University, no. 218 Jixi Road, Hefei, 230022, China. Electronic address:

Introduction: We describe a patient with a large cystic adenomyosis of the uterus who was treated by a laparoscopic approach.

Case Presentation: A 38-year-old woman presented with dysmenorrhoea for 4 months. A 104 mm × 55 mm × 60 mm cystic mass was detected on the right side of the posterior wall of the uterus by ultrasound. Read More

Int J Environ Res Public Health 2020 May 21;17(10). Epub 2020 May 21.

1st Department of Obstetrics and Gynecology, Medical University of Warsaw, 02-015 Warsaw, Poland.

The objective was to evaluate the quality of life and the incidence of depression among women suffering from endometriosis. Afterwards, the dependency between pelvic pain, its severity and stages of endometriosis were analyzed. The study protocol included women of reproductive ages with confirmed endometriosis. Read More

J Minim Invasive Gynecol 2020 May 23. Epub 2020 May 23.

Endoscopica Malzoni, Center for Advanced Endoscopic Gynecologic Surgery, Avellino, Italy. Electronic address:

Objective: To show the surgical steps used to perform rectal disc excision in a context of deep infiltrating endometriosis characterized by contiguity between intestinal lesion and retrocervical region.

Design: Step-by-step video demonstration of the technique.

Setting: Although surgical options for the management of rectosigmoid endometriosis have increasingly been investigated, there is no consensus regarding patient eligibility for shaving, discoid or segmental resection. Read More

Arch Gynecol Obstet 2020 Jul 23;302(1):165-172. Epub 2020 May 23.

Endometriosis Center, Acibadem Fulya Hospital, Istanbul, Turkey.

Purpose: This is a retrospective cohort study that evaluates the postoperative pain findings of a consecutive series of laparoscopic surgeries for deep endometriosis (DE).

Methods: This multi-center retrospective cohort study was carried out in university hospitals (Istanbul, Turkey). Sixty-five patients diagnosed through bimanual gynecologic examination, gynecologic ultrasound or magnetic resonance imaging-confirmed endometrioma and DE together; who underwent a laparoscopic surgery between 2013 and 2019 by a team of gynecologists, colorectal surgeons, and a urologist were retrospectively evaluated. Read More

Sleep Breath 2020 May 23. Epub 2020 May 23.

Sleep Medicine Center, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China.

Purpose: We aimed to investigate the association between sleep disturbance and menstrual problems in female Chinese university students.

Methods: A convenience sample of 1006 female university students participated in this study. Sleep duration, sleep quality, and insomnia symptoms were assessed by the Pittsburgh Sleep Quality Index and the Insomnia Severity Index. Read More

Acta Obstet Gynecol Scand 2020 May 22. Epub 2020 May 22.

The Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University hospital, Helsinki, Finland.

Introduction: Women experience pain during medical abortion, yet optimal pain management remains unclear. We studied the pain experience and need of analgesics during early medical abortion (≤63 days of gestation) among teenaged and adult women. We also assessed predictive factors of severe pain. Read More

Int J Womens Health 2020 4;12:327-338. Epub 2020 May 4.

Department of Physical Medicine and Rehabilitation, Tohoku University, Sendai, Japan.

Background: Dysmenorrhea affects approximately 80% of women in Japan and has a negative impact on health-related quality of life (HRQoL). Low-dose estrogen/progestin combined oral contraceptives have been shown to reduce the severity of dysmenorrhea symptoms. This study characterized HRQoL in Japanese women with dysmenorrhea before and after ethinylestradiol/drospirenone (EE/DRSP) treatment. Read More

Phytother Res 2020 May 20. Epub 2020 May 20.

Department of Biology, College of Science, University of Bahrain, Zallaq, Bahrain.

Ginger has a pain-reducing effect and it can modulate pain through various mechanisms: inhibition of prostaglandins via the COX and LOX-pathways, antioxidant activity, inibition of the transcription factor nf-kB, or acting as agonist of vanilloid nociceptor. This narrative review summarizes the last 10-year of randomized controlled trials (RCTs), in which ginger was traditionally used as a pain reliever for dysmenorrhea, delayed onset muscle soreness (DOMS), osteoarthritis (AO), chronic low back pain (CLBP), and migraine. Regarding dysmenorrhea, six eligible studies suggest a promising effect of oral ginger. Read More

J Ethnopharmacol 2020 May 11;259:112942. Epub 2020 May 11.

Hospital of Chengdu University of Traditional Chinese Medicine, No.37 Shierqiao Road, Chengdu, 610072, China. Electronic address:

Ethnopharmacological Relevance: Euonymus alatus (Thunb.) Siebold (E. alatus), a well-known medicinal plant, has been widely used thousands of years in China for the treatment of various diseases such as urticaria, dysmenorrhea, wound, dysentery, blood stasis, rheumatism and arthritis. Read More

Evid Based Complement Alternat Med 2020 29;2020:8306165. Epub 2020 Apr 29.

The Affiliated Hospital of Jiangxi University of TCM, Nanchang, Jiangxi, China.

Background: Acupuncture and moxibustion have been accepted as treatment options for primary dysmenorrhea (PD). So far, several systematic reviews (SRs) and meta-analyses (MAs) have reported on the efficacy and safety of acupuncture and moxibustion in treating PD.

Objectives: The aim of this study was to critically summarize the evidence from relevant SRs and MAs reporting on the efficacy and safety of acupuncture and moxibustion in treatment of PD. Read More

Res Social Adm Pharm 2020 May 7. Epub 2020 May 7.

Sydney Pharmacy School, Faculty of Medicine and Health, The University of Sydney, Sydney, Australia.

Background: Implicit bias is prejudice shown towards an individual or group without consciously meaning to do so. This bias may occur due to age, race, and gender among other factors. Implicit bias has been examined and identified in a variety of health care professionals, primarily using Implicit Association Tests. Read More

Fertil Steril 2020 Jun 13;113(6):1224-1231.e1. Epub 2020 May 13.

Department of Obstetrics, Gynecology and Reproductive Sciences, Yale School of Medicine, New Haven, Connecticut, USA.

Objective: To determine the relationship between steroid receptor expression and pain symptoms in endometriosis.

Design: Cross-sectional SETTING: University Hospital PATIENT(S): Women with endometriosis (N = 92).

Intervention(s): Tissue samples were obtained from patients with surgically diagnosed endometriosis. Read More

Arch Gynecol Obstet 2020 Jul 15;302(1):153-163. Epub 2020 May 15.

Faculty of Health Sciences, Department of Physiotherapy and Rehabilitation, Eastern Mediterranean University, Famagusta, North Cyprus, via Mersin-10, Turkey.

Purpose: Primary dysmenorrhea is the most common gynecological problem in young women and adolescents. Exercise therapy provides positive effects on women with primary dysmenorrhea. The aim of the study was to investigate the effects of a combined exercise program on pain, sleep and menstrual symptoms in patients with primary dysmenorrhea. Read More

Adv Exp Med Biol 2020 ;1242:73-87

Department of Minimally Invasive Gynecologic Surgery, NYU-Winthrop University Hospital, Mineola, NY, USA.

Endometriosis is a gynecologic disease that affects over 10% of women of reproductive age causing pelvic pain, dysmenorrhea, and infertility, resulting in significant disability and reduced quality of life. Very recent genetic studies have suggested that endometriosis is a clonal disease in the epithelium and its development is independent of stroma, providing new insight into the genesis of endometriosis. The endometrioid tissue lining may also react by epithelial atypical hyperplasia and even neoplasia, in a manner somehow similar to that in the uterine cavity and under the same hormonal influences. Read More

J Ethnopharmacol 2020 May 5:112935. Epub 2020 May 5.

Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education and Yunnan Province, School of Chemical Science and Technology, Yunnan University, Kunming 650091, People's Republic of China; State Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, People's Republic of China. Electronic address:

Ethnopharmacological Relevance: "Curcumae Radix", the dried rhizomes of Curcuma kwangsiensis documented in Chinese pharmacopoeia, has been traditionally used for the treatment of inflammatory and pain diseases, such as jaundice and red urine, cleaning the heart-fire and depression, arthralgia, and dysmenorrhea. However, according to literature surveys, anti-inflammatory and antinociceptive studies of C. kwangsiensis have been seldom reported so far. Read More

Medicine (Baltimore) 2020 May;99(19):e19881

School of Nursing, Jilin University.

Background: Primary dysmenorrhea is common and troublesome. The comparative efficacy of over-the-counter analgesics (OTCAs) for dysmenorrhea is unclear. This study was aimed at conducting a network meta-analysis to assess the efficacy and safety of 5 OTCAs - naproxen, ibuprofen,diclofenac, aspirin, and ketoprofen - in patients with primary dysmenorrhea. Read More

Complement Ther Clin Pract 2020 May 30;39:101160. Epub 2020 Mar 30.

Department of Nursing, College of Health Science, Kangwon National University, 346 Hwangjo-gil, Dogye-eup, Samcheok-si, Gangwon-do, 25949, Republic of Korea. Electronic address:

Objectives: This study assessed the quality of safety reporting in complementary and alternative therapies randomized controlled trials for primary dysmenorrhea.

Methods: Methodologic systematic review of randomized controlled trials published until August 25, 2019 without language restrictions. The adequacies of safety reporting are reported as frequencies and percentages and their predictors were analyzed by multiple least-squares and logistic regressions. Read More

Complement Ther Clin Pract 2020 May 18;39:101148. Epub 2020 Mar 18.

Faculty of Medicine, Department of Biostatistics, Ankara Yildirim Beyazit University, Ankara, Turkey. Electronic address:

Aim: To investigate the effects of kinesio tape (KT) application on pain, anxiety, and menstrual complaints in women with PD and compare this application with control and sham tape (ST).

Methods: Fifty-one women with PD were randomized into three groups: KT, ST, and control groups. No tape application was performed in the control group. Read More

Complement Ther Clin Pract 2020 May 22;39:101120. Epub 2020 Feb 22.

Hacettepe University, Faculty of Physiotherapy and Rehabilitation, 06100, Saman pazarı, Ankara, Turkey. Electronic address:

The aim of this study was to investigate the effects of kinesio taping and lifestyle changes on pain, body awareness, and quality of life in individuals with primary dysmenorrhea (PD). Subjects in the first group underwent kinesio taping and lifestyle changes and subjects in the second group were instructed only lifestyle changes. The pain levels were evaluated using a visual analogue scale, menstrual symptoms using the Menstrual Symptom Questionnaire, health-related life quality using the Short Form-36, and changes in body awareness using the Body Awareness Questionnaire form. Read More

Reprod Biomed Online 2020 Jun 26;40(6):842-850. Epub 2020 Feb 26.

Department of Diagnostic Radiology, Faculty of Medicine, Mansoura University, Mansoura Dakahlia 35516, Egypt.

Research Question: Adenomyosis has been reported in a high proportion (24.4%) of infertile women, but this may be over-representative. What is the exact prevalence of adenomyosis in an infertility clinic population?

Design: In this cross-sectional study, 320 infertile women ≤41 years of age attending the infertility clinic of a university teaching hospital were screened by two-dimensional transvaginal ultrasound (2D-TVS) to look for the sonographic markers of adenomyosis, with subsequent magnetic resonance imaging (MRI) if suspected. Read More

Nutrients 2020 May 2;12(5). Epub 2020 May 2.

Department of Obstetrics and Gynecology, Graduate School of Medical Science, Kanazawa University, Kanazawa 920-8640, Japan.

There are growing concerns that poor dietary behaviors at young ages will increase the future risk of chronic diseases in adulthood. We found that female college students who skipped breakfast had higher incidences of dysmenorrhea and irregular menstruation, suggesting that meal skipping affects ovarian and uterine functions. Since dysmenorrhea is more prevalent in those with a past history of dieting, we proposed a novel concept that inadequate dietary habits in adolescence become a trigger for the subsequent development of organic gynecologic diseases. Read More

Clin Obstet Gynecol 2020 May 1. Epub 2020 May 1.

Department of Pediatric and Adolescent Gynecology and Obstetrics, Nationwide Children's Hospital.

Dysmenorrhea is common in adolescents. Most have primary dysmenorrhea and respond to empiric treatment with nonsteroidal anti-inflammatory drugs and/or hormonal therapies. Infrequently, patients have persistent symptoms requiring further evaluation including a pelvic examination, ultrasonography, and/or diagnostic laparoscopy. Read More

Medicine (Baltimore) 2020 May;99(18):e19737

Department of Obstetrics and Gynecology, College of Korean Medicine.

Introduction: Hypothyroidism, the most common endocrine disease, comprises a deficiency of thyroid hormone, causing coldness, fatigue, and dysmenorrhea. Here, we report the improvement of hypothyroidism symptoms and thyroid hormone level normalization by using Korean herbal medicine and acupuncture therapy.

Patient Concerns: A 30-year-old woman (Case 1) presented at the clinic with continuous seborrheic dermatitis on the scalp, accompanied by dysmenorrhea. Read More

Br J Sports Med 2020 Apr 29. Epub 2020 Apr 29.

School of Health and Life Sciences, University of West of Scotland, Lanarkshire, UK

Objectives: To explore athletes' past and current experiences and perceptions of the menstrual cycle in relation to its impact on sporting performance.

Methods: 15 international female rugby players participated in individual semi-structured interviews (age: 24.5±6. Read More

Sci Rep 2020 Apr 27;10(1):7063. Epub 2020 Apr 27.

Department of Genetics and Evolution, Federal University of São Carlos, São Carlos, SP, Brazil.

Tahiti lemon juice (Citrus latifolia) (TLJ), as a natural source of flavonoids, has been used as an alternative to anti-inflammatory drugs for the treatment of dysmenorrhea and menstrual excessive bleeding, often associated with an imbalance of the prostaglandins (PG) levels. However, despite the positive effects, the mechanisms that rule menstruation control are still unknown. Therefore, the objectives were to characterize the TLJ and analyze its effect on the production of PGF2α, PGE2 and pro-inflammatory cytokines involved inmenstruation. Read More

J Gynecol Obstet Hum Reprod 2020 Apr 20:101761. Epub 2020 Apr 20.

Department of Gynecology, Obstetrics and Gynecology Hospital, Fudan University, China; Shanghai Key Laboratory of Female Reproductive Endocrine-Related Disease, Fudan University, Shanghai, China. Electronic address:

Objective: To identify the risk factors associated with dysmenorrhea in adenomyosis and to discuss the potential hormone-based understanding of pain mechanisms.

Study Design: Adenomyosis patients with mild or no dysmenorrhea (n = 40, Group 1) and moderate-to-severe dysmenorrhea (n = 80, Group 2) were recruited. Charts of all patients were recorded. Read More

Int J Oncol 2020 Apr 31;56(4):969-985. Epub 2020 Jan 31.

Department of Biochemistry, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand.

Breast cancer is the most common type of cancer and is also the second leading cause of cancer‑associated death in women worldwide. Thus, there is an urgent requirement for the development of effective treatments for this disease. Bridelia ovata and Croton oblongifolius are herbs used in Thai traditional medicine that have been used to treat various health problems; B. Read More

BMC Womens Health 2020 Apr 21;20(1):75. Epub 2020 Apr 21.

Institute of Pediatrics, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, 9 Jinsui Road, Zhujiang Newtown, Tianhe District, Guangzhou, 510623, China.

Background: Diverticulum, one of the long-term sequelae of cesarean section, can cause abnormal uterine bleeding, dysmenorrhea and chronic pelvic pain. Hysteroscopic resection of diverticula is thought to reduce abnormal uterine bleeding and chronic pelvic pain. In this study, we aim to describe the improvement after hysteroscopic resection of cesarean section diverticula (CSD) in women without childbearing intention, and to explore the variables associated with poor prognosis. Read More

Complement Med Res 2020 Apr 21:1-5. Epub 2020 Apr 21.

Physical Therapy and Rehab Private Naturel Health Clinic, Istanbul, Turkey.

Background: In this study, we aimed to assess the effect of neural therapy in the prevention of post-tubal syndrome, which is the combination of dysmenorrhea, bloating, dyspareunia, heavy menstrual bleeding, chronic vaginitis, and cystitis, after elective bilateral tubal ligation with modified Pomeroy technique.

Material And Methods: In total, 113 patients who have undergone bilateral tubal ligation with modified Pomeroy technique between January 2016 and December 2018 in our clinic have been included. Postoperatively, patients were divided into two groups. Read More

J Obstet Gynaecol 2020 Apr 21:1-14. Epub 2020 Apr 21.

Gynaecology and Human Reproduction Physiopathology, Dipartimento di Scienze Mediche e Chirurgiche (DIMEC), S. Orsola Hospital, University of Bologna, Bologna, Italy.

Endometriosis, defined as the presence of functional endometrial tissue outside the uterine cavity, presents mainly with pelvic pain and infertility. Acute abdominal pain in non-pregnant patients with endometriosis might be minimised as a typical feature of the disease, while endometriosis is rarely considered in the differential diagnosis of acute abdominal pain. Our objective was to conduct a systematic review of the current literature of cases of acute abdomen/acute abdominal pain in non-pregnant endometriotic patients. Read More

J Ethnopharmacol 2020 Aug 18;258:112874. Epub 2020 Apr 18.

Department of Oriental Medicine Biotechnology, College of Life Sciences, Kyung Hee University, Yongin, 17104, Republic of Korea. Electronic address:

Ethnopharmacological Relevance: Salvia miltiorrhiza is a traditional oriental medicine widely used for preventing and treating disorders of the liver, menstrual, and blood circulation systems. Osteoporosis, loss of bone with age and/or estrogen deficiency, is an important causal factor of fracture. S. Read More

Int J Womens Health 2020 5;12:243-251. Epub 2020 Apr 5.

Health Science Center, Federal University of Rio Grande do Norte, Rio Grande do Norte, Brazil.

Background: Primary dysmenorrhea is a common and often debilitating condition affecting 40-90% of menstruating women. This condition reduces functionality, quality of life, and social activities. Transcranial direct current stimulation (tDCS) has been used in many chronic pain syndromes, with evidence of improved pain, functionality, and mood in women with primary dysmenorrhea. Read More

Horm Mol Biol Clin Investig 2020 Apr 17. Epub 2020 Apr 17.

Department of Obstetrics and Gynaecology, Universiti Kebangsaan Malaysia Medical Centre, Kuala Lumpur, Malaysia.

Background The objective was to compare the effectiveness and tolerability of mefenamic acid and celecoxib in women with primary dysmenorrhea (PD) and to compare the quality of life of study participants pre- and post-treatment. Materials and methods This was a randomized crossover clinical trial conducted among sexually inactive female adults aged 18-25 years with PD. Participants were asked to rate their pain score and answer a validated quality of life questionnaire (EQ-5D-3L) before and after consumption of each medication in two menstrual cycles. Read More

Adv Ther 2020 May 16;37(5):2528-2537. Epub 2020 Apr 16.

Bayer AG, 13353, Berlin, Germany.

Introduction: Endometriosis is a common gynecologic disease associated with a significant burden on women's health and healthcare systems. Currently approved hormonal treatments for endometriosis can be effective in controlling symptoms, but may have clinically relevant side effects that limit their long-term use. Dienogest 2 mg (Visanne; Bayer AG, Berlin, Germany) is a 19-nortestosterone derivative that significantly reduces menstrual bleeding, dysmenorrhea, premenstrual pain, dyspareunia, and pelvic pain in women with endometriosis. Read More

Integr Med Res 2020 Jun 21;9(2):100394. Epub 2020 Feb 21.

Jaseng Hospital of Korean Medicine, 536 Gangnam-daero, Gangnam-gu, Seoul, 06110, Republic of Korea.

Background: Dangguijagyag-san, also known as Dangguishaoyao-san in Chinese and Toki-shakuyakui-san in Japanese, has been frequently used to treat symptoms associated with dysmenorrhea. The purpose of this trial is to evaluate the efficacy and safety of the herbal medicine, Dangguijagyag-san, relative to those of active control, Gamisoyo-san, and a placebo control for primary dysmenorrhea.

Methods: This protocol details a randomized, double-blind, parallel-group, multi-center, investigator-initiated, controlled trial evaluating treatment of primary dysmenorrhea. Read More

J Caring Sci 2020 Mar 1;9(1):47-56. Epub 2020 Mar 1.

Department of Midwifery, School of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Primary dysmenorrhea is considered as one of the main problems in women. This review study aimed to characterize the effect of micronutrients on primary dysmenorrhea. In this systematic and meta-analysis study, the articles were searched at Cochrane library, PubMed, Scopus, Web of Science databases. Read More

PLoS One 2020 15;15(4):e0231201. Epub 2020 Apr 15.

Department of Social Medicine and Health Management, School of Medicine, Hunan Normal University, Changsha, China.

Background: Emerging studies have found inconsistent results on the potential relationship between cigarette smoking and dysmenorrhea. Therefore, the aim of this study was to quantitatively synthesize the previous findings on the preceding relationship using meta-analysis.

Methods: Previous studies on the association between cigarette smoking and dysmenorrhea, published not later than November 2019, were systematically searched, using MeSH heading and/or relevant terms, in the electronic databases of PubMed, Medline, Web of Science and EMBASE. Read More

Sci Rep 2020 Apr 14;10(1):6341. Epub 2020 Apr 14.

The Department of Public Health, Faculty of Health Sciences, Ben-Gurion University of the Negev, POB 653, Beer-Sheva, 84105, Israel.

The ratio between the length of second and fourth digits (2D:4D) is a putative biomarker for prenatal testosterone and estrogen exposure. The aim of the study was to examine the association between 2D:4D and women's general and reproductive health. This analysis was conducted within a prospective pregnancy cohort study. Read More

J Clin Endocrinol Metab 2020 Jul;105(7)

Shanghai OB/GYN Hospital, Fudan University, Shanghai, China.

Context: Whether endometriosis is a progressive disease is a highly contentious issue. While progression is reported to be unlikely in asymptomatic deep endometriosis, progression in symptomatic deep endometriosis has recently been reported, especially in menstruating women. However, pathophysiological reasons for these differences are unclear. Read More