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J Clin Med 2022 May 9;11(9). Epub 2022 May 9.

Clinic of Gynecology, Obstetrics and Gynecological Oncology, University Hospital for Gynecology, Pius-Hospital Oldenburg, Medical Campus University of Oldenburg, 26121 Oldenburg, Germany.

(1) Background: Uterine niche is a frequent condition in patients with a history of cesarean section. Although the relation to uterotomy seems to be clear, the exact pathogenesis is not fully understood. Uterine niche can easily be diagnosed by transvaginal ultrasound. Read More

Reprod Sci 2022 May 13. Epub 2022 May 13.

Department of Physiotherapy and Rehabilitation, Faculty of Physical Therapy and Rehabilitation, Hacettepe University, 06100, Samanpazari, Ankara, Turkey.

The aim of this study was to identify the effects of connective tissue manipulation (CTM) in primary dysmenorrhea (PD) in a randomized, placebo-controlled design. Thirty-eight nulliparous women with PD were randomly allocated into 3 groups: CTM (n = 13), placebo therapeutic ultrasound (US) (n = 13), and control (n = 12). The primary outcome measure was the maximum and mean menstrual pain intensity at the last menstrual period on the visual analogue scale (VAS). Read More

FASEB J 2022 May;36 Suppl 1

Ponce Health Sciences University-Ponce Research Institute, Ponce, PR.

Introduction: Endometriosis is a complex gynecological disorder characterized by the ectopic growth of endometrial tissue. Symptoms of endometriosis are known to impair the quality of life of patients, among these symptoms are dysmenorrhea, chronic pelvic pain, and gastrointestinal (GI) issues. These GI issues are one of the common reasons for misdiagnosis with irritable bowel syndrome (IBS), a pain syndrome characterized by abdominal pain, painful bowel movements, diarrhea, and constipation, all of which are often present in endometriosis and persist even after treatment. Read More

J Minim Invasive Gynecol 2022 May 9. Epub 2022 May 9.

Department of Obstetrics and Gynecology, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.

Objective: To show a conservative surgical treatment for women affected by Wunderlich syndrome with didelphyc uterus and obstructed hemivagina.

Design: Stepwise demonstration of the technique with narrated video footage.

Setting: In the context of obstructive congenital Mullerian anomalies, involving a stagnation of menstrual blood, the Wunderlich syndrome is the most common and constantly characterized by the duplicity of the uterine body, by the presence of an imperforate hemivagina and by renal agenesis ipsilateral to the obstructed hemivagina. Read More

Medicine (Baltimore) 2022 May 6;101(18):e29155. Epub 2022 May 6.

Department of Acupuncture and Tuina, Changchun University of Chinese Medicine, Changchun, China.

Background: Primary dysmenorrhea (PD) is a painful disease that severely affects the daily lives of young women. External therapy using traditional Chinese medicine (TCM) is widely used in the clinical treatment of this disease and has achieved a good effect. There are many kinds of TCM external therapies, but the effectiveness, safety, and advantages of various methods have not been confirmed by high-quality meta-analyses. Read More

Case Rep Obstet Gynecol 2022 2;2022:7931391. Epub 2022 May 2.

Crispi Institute of Minimally Invasive Surgery, Rio de Janeiro, RJ, Brazil.

A 36-year-old Caucasian, nulliparous patient sought care at a private gynecology clinic after 6 months of attempting to conceive. During the initial consultation, the patient reported severe dysmenorrhea and deep dyspareunia. During the gynecological examination, a nodule in the left lateral vaginal fornix was palpable. Read More

Pain 2022 May 10. Epub 2022 May 10.

Department of Obstetrics and Gynecology, NorthShore University HealthSystem, Evanston, IL, USA.

Abstract: Dysmenorrhea is characterized by high rates of transition to chronic pain. In a previous study using structural equation modeling we demonstrated that several symptom domains associated with the emerging concept of nociplastic pain can be described using two symptom groups: generalized sensory sensitivity (GSS; composed of widespread pain, interceptive sensitivity, and environmental sensitivity) and SPACE (composed of unrefreshing Sleep, Pain, Affective disturbances, Cognitive issues, and reduced Energy). Here we perform a secondary cross-sectional analysis examining the same symptoms groups in a cohort of dysmenorrhea patients without a diagnosis of chronic pain. Read More

Curr Probl Pediatr Adolesc Health Care 2022 May 3:101186. Epub 2022 May 3.

Division of Adolescent Medicine, Cohen Children's Medical Center, Northwell Health, 410 Lakeville Road, Suite 108, New Hyde Park, New York, USA; Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, New York, USA.

Studies show that between 41% and 91.5% of young women, school-aged and university-aged, are affected by dysmenorrhea. Primary dysmenorrhea, which is caused by the production of prostaglandins, is defined as cramping pain in the lower abdomen and/or pelvis occurring just before or during menstruation, in the absence of other diseases such as endometriosis, and typically lasting 1-3 days and with a negative physical examination. Read More

Value Health 2022 May 3. Epub 2022 May 3.

Department of Reproductive Medicine, Xiangya Hospital, Central South University, Changsha, Hunan Province, China; The Clinical Research Center for Women's Reproductive Health in Hunan Province, Changsha, Hunan Province, China. Electronic address:

Objectives: Primary dysmenorrhea (PD), as the most common complaint among students, is also one of the public problems worldwide. Prevalence and risk factors of PD were variant between studies; as the main population, no meta-analysis for PD has hitherto been conducted in students.

Methods: We searched the published literature in PubMed, Embase, the Cochrane Library, Web of Science, National Knowledge Infrastructure, WANFANG, and VIP database. Read More

BMJ Case Rep 2022 May 6;15(5). Epub 2022 May 6.

Department of Fetal Medicine, Liverpool Women's NHS Foundation Trust, Liverpool, UK.

Müllerian anomalies such as Robert's uterus, which was first described by the French gynaecologist Dr Helene Robert in 1969, are rare clinical entities and have been reported in <3% of the female population. Robert's uterus is a rare phenomenon with a relative dearth of reported cases. Affected individuals may present with pelvic pain and dysmenorrhoea that intensifies near menses or acutely, with severe abdominal pain to the emergency department. Read More

Front Surg 2022 19;9:873698. Epub 2022 Apr 19.

Department of Pharmacy, Zhoushan Hospital of Zhejiang Province, Zhoushan, China.

Objective: To explore the curative effect of laparoscopic surgery combined with leuprorelin in the treatment of endometriosis with infertility and the related factors of recurrence after treatment.

Methods: A total of 158 patients with endometriosis and infertility were selected in our hospital from January 2019 to June 2020. Patients were randomly divided into the control group and the observation group, with 79 patients in each group. Read More

Acta Obstet Gynecol Scand 2022 May 5. Epub 2022 May 5.

Department of Obstetrics and Gynecology, Erlangen University Hospital, Friedrich Alexander University of Erlangen-Nuremberg, Erlangen, Germany.

Introduction: Cryopreservation of ovarian tissue with subsequent transplantation is an efficient option for restoring fertility in women at risk of premature ovarian failure. The association between infertility and endometriosis is well recognized. Although endometriosis usually ends with the onset of natural or iatrogen menopause due to declining estrogen levels, endometriosis can in rare cases occur after menopause. Read More

Sci Rep 2022 May 3;12(1):7146. Epub 2022 May 3.

Department of Physiotherapy, Faculty of Allied Health Sciences, University of Peradeniya, Peradeniya, 20400, Sri Lanka.

Primary dysmenorrhea (PD) is a common gynecological condition among adolescent and adult women. Several pharmacological and alternative therapies (e.g. Read More

Clin Nurs Res 2022 May 2:10547738221086984. Epub 2022 May 2.

Institute of Chinese Acuology, Perth, WA, Australia.

Acupuncture and moxibustion have been accepted as add-on options for primary dysmenorrhea (PD); however, the clinical evidence is still inadequate. We searched AMED, CENTRAL, EMBASE, PubMed, Web of Science, CBM, CNKI, VIP, Wangfang database, ANZCTR, ClinicalTrials.gov, and the WHO ICTRP, from their inception to February 2021. Read More

Front Med (Lausanne) 2022 15;9:804494. Epub 2022 Apr 15.

Department of Radiology, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, China.

Objective: Ethiodized poppy seed oil for hysterosalpingography (HSG) is reported to display some therapeutic effect on infertility, but big a sample-size study under real clinical settings is still lacking to verify the speculation. Thus, this real-world study enrolled 1,053 infertile patients who underwent ethiodized poppy seed oil-based HSG to explore its fertility enhancement value.

Method: A total of 1,053 infertile patients who underwent HSG using ethiodized poppy seed oil as the contrast medium were retrospectively analyzed. Read More

Prog Urol 2022 Apr 28. Epub 2022 Apr 28.

Université Paris Sorbonne, Assistance Publique Hôpitaux de Paris (AP-HP), Hôpital Tenon, 4, rue de la Chine, 75020 Paris, France.

Sex Reprod Healthc 2022 Apr 26;32:100730. Epub 2022 Apr 26.

Sexual Health Sheffield, United Kingdom.

We aimed to observe the continuation of Emergency IUD beyond the index cycle and reasons for removal. We analysed data from the patients' electronic records of fifty consecutive women who had an IUD fitted at Sexual Health Sheffield for emergency contraception. 48 (96%) women continued with the IUD beyond the index cycle and 31 (62%) women for more than 1 year. Read More

J Osteopath Med 2022 May 2. Epub 2022 May 2.

Women's Health Department, Faculty of Physical Therapy, Cairo University, Giza, Egypt.

Context: Research is lacking regarding osteopathic approaches in treating polycystic ovary syndrome (PCOS), one of the prevailing endocrine abnormalities in reproductive-aged women. Limited movement of pelvic organs can result in functional and structural deficits, which can be resolved by applying visceral manipulation (VM).

Objectives: This study aims to analyze the effect of VM on dysmenorrhea, irregular, delayed, and/or absent menses, and premenstrual symptoms in PCOS patients. Read More

J Pediatr Surg 2022 Apr 15. Epub 2022 Apr 15.

Department of Pediatric Surgery, Bambino Gesù Pediatric Hospital, Piazza di Sant'Onofrio, 4, Roma 00165, Italy.

Background: OHVIRA (Obstructed Hemivagina and Ipsilateral Renal Anomaly or Herlyn-Werner-Wunderlich syndrome) is a rare Müllerian malformation. Usually, symptoms begin with worsening dysmenorrhea in post-menarche adolescents. The management in pre-menarche period is controversial and has only recently been subject of study. Read More

J Minim Invasive Gynecol 2022 Apr 26. Epub 2022 Apr 26.

Department of Public Health, University of Naples Federico II. Naples, Italy.

Objective: To describe the diagnostic work up and laparoscopic management of a non-communicating left Uterine Rudimentary Horn (Class U4aC0V0 ESHRE/ESGE Classification) with communicating endometriotic bladder nodule.

Design: Step-by-step description of the surgical treatment.

Patient: A 33-years-old woman with unicornuate uterus and a left-side non-communicating rudimentary horn affected by primary infertility, mild dysmenorrhea (VAS Score 6), severe catamenial dysuria (VAS Score 10) and catamenial hematuria. Read More

Arch Gynecol Obstet 2022 Apr 29. Epub 2022 Apr 29.

Department of Center for Reproductive Medicine, Center for Prenatal Diagnosis, First Hospital, Jilin University, 71 Xinmin Street, Chaoyang District, Changchun, 130021, Jilin Province, China.

Purpose: To summarize the clinical characteristics and surgical option of Robert's uterus.

Methods: We reported a rare case of Robert's uterus with severe uterine adhesion with successive laparoscopic and hysteroscopic surgery. To our knowledge, such a case has not been reported previously. Read More

Zhonghua Fu Chan Ke Za Zhi 2022 Apr;57(4):265-270

Center for Gynecology, Women's and Children's Hospital Affiliated to Qingdao University, Qingdao 266011, China.

To retrospectively analyze the pregnancy outcomes of patients with adenomyosis requiring fertility in a single center under real world condition. From June 2015 to May 2020, 231 cases of pregnancy complicated with adenomyosis diagnosed by ultrasound with fertility requirements were treated in the Women's and Children's Hospital Affiliated to Qingdao University with complete clinical data. And they were divided into three groups according to the treatment of adenomyosis before pregnancy: expectation group, drug group and operation group. Read More

Zhonghua Fu Chan Ke Za Zhi 2022 Apr;57(4):259-264

State Key Laboratory of Ultrasound in Medicine and Engineering, College of Biomedical Engineering, Chongqing Medical University, Chongqing 400016, China.

To investigate the relationship between the clinical efficacy and the ablated area of endometrium in patients with internal adenomyosis treated with focused ultrasound ablation surgery (FUAS). From January 2015 to December 2018, 122 patients in Chongqing Haifu Hospital who were diagnosed as internal adenomyosis through history, clinical symptoms and enhanced magnetic resonance imaging (MRI) and treated with FUAS were enrolled in this study. According to the patient's wishes, patients were given whether to ablate the adenomyotic lesion alone or ablate the adenomyotic lesion and the endometrium that involved in adenomyotic lesions together. Read More

Appl Immunohistochem Mol Morphol 2022 Apr 28. Epub 2022 Apr 28.

Department of Pathology, State University of New York-Upstate Medical University, Syracuse, NY.

Transcription factor E3 (TFE3) represents a useful target for immunohistochemistry assays in routine surgical pathology practice. This protein has shown nuclear expression in a variety of normal tissues; however, this expression is usually at very low levels, while strong nuclear immunoreactivity of TFE3 has been seen almost exclusively in tumors. We present the case of a 30-year-old female on oral contraceptive pill (drospirenone/ethinylestradiol) and with complaints of dysmenorrhea and menorrhagia. Read More

Dtsch Arztebl Int 2022 May 23(Forthcoming). Epub 2022 May 23.

Background: Endometriosis is a chronic, benign disease that affects approximately 10% of women of childbearing age. Its characteristic clinical features are dysmenorrhea, dyschezia, dysuria, dyspareunia, and infertility. The manifestations of extragenital endometriosis (EE) are a diagnostic challenge, as this disease can mimic other diseases due to its unusual location with infiltration of various organs and corresponding symptoms. Read More

Am J Chin Med 2022 Apr 26:1-17. Epub 2022 Apr 26.

Department of Gynecology, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, People's Republic of China.

Endometriosis is a chronic, estrogen-dependent condition that causes dysmenorrhea and pelvic pain. Chinese herbal medicine (CHM) has been used for endometriosis for many years in Asian populations. This is a retrospective study in a territory teaching hospital of the China Academy of Chinese Medical Sciences in Beijing, China to compare the short- and long-term effectiveness and safety of CHM for endometriosis associated pain (EAP) before and after CHM treatment. Read More

J Integr Complement Med 2022 Apr 26. Epub 2022 Apr 26.

Osher Center for Integrative Medicine, Harvard Medical School and Brigham and Women's Hospital, Boston, MA, USA.

Despite substantial progress made in the field of acupuncture research, the existence and specificity of acupoints remain controversial. In recent years, the concept of acupoint sensitization has emerged as a theoretical framework for understanding acupoints as dynamic functional entities that are sensitized in pathological conditions. Based on this premise, some have claimed that specific acupoints are thermally distinct between healthy and clinical populations, but no systematic review has been conducted to synthesize and evaluate the quality of studies supporting such claims. Read More

Biol Reprod 2022 Apr 26. Epub 2022 Apr 26.

Department of Obstetrics and Gynecology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, People's Republic of China.

Background: Endometriosis is a benign gynecologic disease that causes chronic pelvic pain, dysmenorrhea and infertility and shares several characteristics with malignant tumors, afflicting women of reproductive age. Hexokinase 2 (HK2) plays an essential role as the first rate-limiting enzyme in the metabolic glycolysis pathway, and its abnormal elevation in tumors is associated with tumor genesis and metastasis. However, the expression and role of HK2 in endometriosis remain unclear. Read More

J Chiropr Med 2021 Sep 31;20(3):148-157. Epub 2022 Jan 31.

National University of Health Sciences Basic Science Department, Pinellas Park, Florida.

Objective: The purpose of this case report is to describe the conservative management of a patient with headaches, lumbopelvic pain, and dysmenorrhea.

Clinical Features: A 36-year-old woman presented with intense pelvic and daily lumbar pain. She had difficulty sleeping and focusing and had 3 to 4 headaches per week. Read More