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Zhongguo Zhong Yao Za Zhi 2021 Apr;46(8):1960-1966

School of Chinese Medicine, Beijing University of Chinese Medicine Beijing 100029, China.

Aspalathus linearis is a needle-shaped shrub that grows in the Cedarberg mountains in southern South Africa, with an extremely high medicinal value. In 2014, China has approved A. linearis as a new food material. Read More

Curr Dev Nutr 2021 May 9;5(5):nzab064. Epub 2021 Apr 9.

Department of Cellular and Molecular Function Analysis, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan.

Background: Skipping breakfast is associated with dysmenorrhea in young women. This suggests that the delay of food intake in the active phase impairs uterine functions by interfering with circadian rhythms.

Objectives: To examine the relation between the delay of feeding and uterine circadian rhythms, we investigated the effects of the first meal occasion in the active phase on the uterine clock. Read More

Front Pharmacol 2021 26;12:658628. Epub 2021 Apr 26.

The First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, Guiyang, China.

(Franch.) T.N. Read More

Cochrane Database Syst Rev 2021 May 11;5:CD011169. Epub 2021 May 11.

Isala Hospitals Zwolle, Zwolle, Netherlands.

Background: Endometriosis is defined as the presence of endometrial tissue outside the uterine cavity. This chronic and recurring condition occurs in women of reproductive age. It is a common cause of pain or infertility and can cause non-specific symptoms such as lower back pain, dyspareunia (pain during or after intercourse), and dysmenorrhoea (menstrual pain). Read More

Int J Clin Pract 2021 May 11:e14350. Epub 2021 May 11.

Department of Obstetrics and Gynecology, School of Medical Sciences, University of Campinas.

Aims: Deep infiltrative endometriosis (DIE) may cause pelvic pain and thus negatively affect the function of different structures. We hypothesized that women with DIE may have dysfunctions of the pelvic floor muscles (PFM) and lower limb muscles (LLM).

Methods: This cross-sectional study included 160 women (80 with DIE under hormonal treatment and 80 women without DIE), who were assessed to determine the presence of pelvic symptoms (dysmenorrhea, chronic pelvic pain (CPP), deep/penetration dyspareunia, dysuria, dyschezia, and vulvodynia), PFM function (PERFECT scheme, presence of hypertonia and trigger points, and muscle contraction and relaxation), abdominal muscle pain (Carnett's test), and muscle shortening in LLM (Thomas, Pace, and Ober tests). Read More

Food Funct 2021 May 10. Epub 2021 May 10.

Royal Society of Chemistry, Thomas Graham House, Science Park, Milton Road, Cambridge, CB4 0WF, UK.

Retraction of 'Ginsenoside Rf alleviates dysmenorrhea and inflammation through the BDNF-TrkB-CREB pathway in a rat model of endometriosis' by Xuying Qin et al., Food Funct., 2019, 10, 244-249, DOI: 10. Read More

Sex Reprod Health Matters 2021 Dec;29(1):1915940

Professor, The Water Institute, Department of Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.

Reports of school and work absences due to unmet menstrual needs have prompted increased attention to menstruation in policy and practice. However, there appear to be few quantitative studies reported in published literature capturing the prevalence of this hypothesised absenteeism. This study undertook secondary analysis of nationally representative Performance Monitoring and Accountability 2020 (PMA2020) data from Burkina Faso and Nigeria, and city-representative data from Niamey, Niger to determine the extent of women's and girls' self-reported absence from school and work due to menstruation. Read More

J Complement Integr Med 2021 May 10. Epub 2021 May 10.

Laboratories for Biomembrane Research and Biotechnology, Department of Biochemistry, University of Ibadan, Ibadan, Nigeria.

Objectives: Decoction of fruit is used in folkloric medicine for treating dysmenorrhea and gonorrhea. Phytochemicals from may be potent in inducing mitochondrial-dependent apoptosis via the opening of the mitochondrial permeability transition (MPT) pore. Therefore, this study investigated the effects of stigmasterol isolated from the chloroform fraction of (CFAB) and also the increasing concentration of CFAB on the opening of rat liver mitochondrial permeability transition (MPT) pore. Read More

Br J Gen Pract 2021 May 4. Epub 2021 May 4.

The Healthcare Improvement Studies Institute, Cambridge, United Kingdom.

Background: Endometriosis affects approximately 10% of women, with well-documented delays between initial presentation with symptoms and diagnosis. In England, women typically seek help first in primary care, making this setting pivotal in women's pathways to diagnosis and treatment. English General Practitioner (GP) perspectives on managing possible endometriosis have not been previously reported. Read More

Int J Environ Res Public Health 2021 Apr 29;18(9). Epub 2021 Apr 29.

Department of Gynecology, Obstetrics and Oncological Gynecology, Medical University of Silesia in Katowice, Markiefki 87, 40-211 Katowice, Poland.

Endometriosis is a common chronic gynecological disorder that undoubtedly impacts on quality of life, and is one of the more complex and mysterious illnesses of our century, which is associated with the improper growth of endometrial tissue outside of the uterine cavity. This pathologically implanted tissue can be found most frequently in the minor pelvis, but also in the peritoneal cavity, and can affect many organs, leading to chronic pelvic pain syndrome, infertility, and dysmenorrhea. Endometrial tissue is a particularly dynamic tissue that has a direct impact on the progression of the disease, with altered immunity, as well as cytokine storms within the metaplastic endometriotic site, as possible key factors. Read More

PLoS One 2021 3;16(5):e0250685. Epub 2021 May 3.

Centre for Health, Activity, and Rehabilitation Research, School of Physiotherapy, University of Otago, Dunedin, Otago, New Zealand.

Background: Chinese herbal footbaths are an external therapy of traditional Chinese medicine that has been widely used to treat dysmenorrhea. This review aims to systematically evaluate its efficacy and safety for the treatment of dysmenorrhea.

Methods: Databases of PubMed, EMBASE, Cochrane Library, CIHAHL, Web of Science, Chinese National Knowledge Infrastructure(CNKI), Chinese Scientific Journals Database (VIP), Wanfang Database, China Biomedical Literature Database(CBM), and Chinese Biomedical Literature Service System (SinoMed) will be searched from the inception to September 30, 2020. Read More

Int J Gynecol Pathol 2021 May 3. Epub 2021 May 3.

Department of Laboratory Medicine, Divison of Clinical Pathology, Sahlgrenska University Hospital (G.M., L.M.A.) Gynecology Outpatient Center, Frölunda Specialist Hospital (F.R.) Department of Infectious Diseases, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg (S.A., C.W.) Department of Clinical Microbiology, Sahlgrenska University Hospital (C.W.), Göteborg, Sweden.

Increased number of eosinophils in the uterus has been reported under physiological and pathologic conditions. However, eosinophilic infiltration limited to the myometrium is very unusual. A rare finding of isolated eosinophilic infiltration in the myometrium without involvement of endometrium or pathologies in the cervix or ovaries was observed in a 31-yr-old woman seeking medical attention for unexplained infertility, abnormal uterine bleeding, and dysmenorrhea. Read More

Am Fam Physician 2021 May;103(9):525-526

Fairfax Family Practice, Fairfax, VA, USA.

Acta Neurol Belg 2021 Apr 29. Epub 2021 Apr 29.

Department of Neurology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.

Many studies have described the features of menstrually related migraines but there is a lack of knowledge regarding the features of migraine in combined hormonal contraceptive users (CHC). Hormone-withdrawal migraines in the pill-free period could differ from those in the natural cycle. Gynaecologic comorbidities, like dysmenorrhea and endometriosis, but also depression or a family history might modify the course of migraine. Read More

Nutrients 2021 Apr 2;13(4). Epub 2021 Apr 2.

Clinical Pharmacy Department, Faculty of Pharmacy, Ain Shams University, Cairo 11566, Egypt.

Diet and nutrition are fundamental in maintaining the general health of populations, including women's health. Health status can be affected by nutrient deficiency and vice versa. Gene-nutrient interactions are important contributors to health management and disease prevention. Read More

Int J Environ Res Public Health 2021 Apr 7;18(8). Epub 2021 Apr 7.

School of Nursing, Kaohsiung Medical University, No. 100, Shih-Chuan 1st Road, Kaohsiung 807, Taiwan.

Irritable bowel syndrome (IBS) is a common recurrent functional gastrointestinal disorder that impacts on patients physically and mentally. Studies on IBS have focused on adults, yet few studies have examined IBS among female university students. The aim of this study was to investigate the prevalence of IBS for female university students and its related factors. Read More

J Pediatr Adolesc Gynecol 2021 Apr 25. Epub 2021 Apr 25.

Department of Pediatrics, Division of Adolescent Medicine, Hacettepe University Faculty of Medicine, Ankara, Turkey. Electronic address:

Study Objective: This study aimed to evaluate the presence of anovulation in adolescents with Primary Dysmenorrhea (PD).

Design: Prospective cohort study SETTING: Hacettepe University Children's Hospital, Adolescent Medicine outpatient clinic between September 2018 and September 2019 PARTICIPANTS: Healthy female adolescents (between 11-18 years of age) with regular menstruation with a score of 1-3 according to 'Numerical rating scale' (NRS), and grade 0 (no limitation for daily activities, no analgesic need and systemic symptoms) according to the 'Verbal multidimensional scoring system' (VBSS) were recruited as control group. The participants who met the diagnostic criteria for PD with a NRS score ≥ 4, had analgesic need in at least the last 3 menstrual cycles, defined moderate-severe PD according to VMSS (Grade 2-3) and had analgesic need every time were accepted as the PD group. Read More

Medicine (Baltimore) 2021 Apr;100(17):e25757

Department of Gynecology, Tongde Hospital of Zhejiang Province, Hangzhou, Zhejiang, PR China.

Abstract: The purpose of this study was to explore the relevant factors that affect the risk of cesarean scar diverticulum (CSD).A retrospective, case-control study was designed among women with a history of cesarean section (CS) who were admitted in Zhejiang Tongde Hospital from January 2017 to December 2019. Women with missing information were excluded. Read More

Minerva Obstet Gynecol 2021 Apr 27. Epub 2021 Apr 27.

Department of Radiological, Oncological and Pathological Sciences, Policlinico Umberto I, Sapienza, University of Rome, Rome, Italy -

Introduction: Endometriosis affects 10%-15% of women in reproductive age and may cause no-cyclic chronic pelvic pain, dysmenorrhea, dyspareunia, urinary tract symptoms, and it is frequently associated with infertility. The peak of incidence is between 24 and 29 years old and the clinical diagnosis of endometriosis is generally delayed by 6-7 years. Laparoscopy with surgical biopsies is the "gold standard" for the diagnosis of endometriosis, with histological verification of endometrial ectopic glands and/or stroma. Read More

Minerva Obstet Gynecol 2021 Apr 27. Epub 2021 Apr 27.

Department of Maternal and Child Health and Urological Sciences, Policlinico Umberto I, Sapienza University of Rome, Rome, Italy -

Endometriosis is a chronic inflammatory disease that affects approximately 10% of women of reproductive age. Its clinical manifestations are highly heterogeneous, but pelvic pain is the most frequent, causing functional disability. Cyclic or acyclic chronic pelvic pain (CPP), dysmenorrhea and dyspareunia are frequent symptoms which often compromise all aspects of the women's quality of life (QoL). Read More

J Matern Fetal Neonatal Med 2021 Apr 25:1-7. Epub 2021 Apr 25.

Department of Sanitary Chemistry, School of Public Health, Guangxi Medical University, Nanning, China.

Objective: Little is known about the association between maternal history of dysmenorrhea and perinatal outcomes. The aim of this study was to investigate the association between maternal history of dysmenorrhea and low birth weight (LBW).

Methods: A total of 6754 pregnant women were recruited from the ongoing prospective cohort study in Guangxi, China, in 2015-2018. Read More

PLoS One 2021 23;16(4):e0250046. Epub 2021 Apr 23.

Crispi Institute of Minimally Invasive Surgery, Rio de Janeiro, Rio de Janeiro, Brazil.

Study Objective: To assess individual changes of deep dyspareunia (DDyspareunia) six months after laparoscopic nerve-sparing complete excision of endometriosis, with or without robotic assistance.

Methods: This preplanned interdisciplinary observational study with a retrospective analysis of intervention enrolled 126 consecutive women who underwent surgery between January 2018 and September 2019 at a private specialized center. Demographics, medical history and surgery details were recorded systematically. Read More

Facts Views Vis Obgyn 2021 Mar 31;13(1):41-49. Epub 2021 Mar 31.

Department of Obstetrics and Gynecology, University Hospitals Schleswig-Holstein, Campus Kiel, Arnold-Heller-Str. 3, 24105 Kiel, Germany.

A septate uterus with a non-communicating hemicavity was first described by Robert in 1969/70 as a specific malformation of the uterus. The condition is commonly associated with a blind uterine hemicavity, unilateral haematometra, a contralateral unicornuate uterine cavity and a normal external uterine fundus. The main symptoms are repetitive attacks of pain at four-weekly intervals around menarche, repeated dysmenorrhea, recurrent pregnancy loss and infertility. Read More

Trials 2021 Apr 21;22(1):299. Epub 2021 Apr 21.

University of New South Wales, Royal Hospital for Women, Randwick, NSW, 2031, Australia.

Background: Endometriosis is the presence of tissue similar to that of the endometrium outside the uterine cavity and is the most common cause of chronic pelvic pain. Current non-surgical treatments such as non-steroidal anti-inflammatories, oral contraceptive pills and hormonal treatments have limited effectiveness, and the side effect profile is bothersome. This study will evaluate the efficacy of Gynoclear™ by change in endometriosis-related pain based on the Endometriosis Pain Daily Diary (EPPD) scores. Read More

Medicine (Baltimore) 2021 Apr;100(16):e25329

Department of Obstetrics and Gynecology, Peking University Ninth School of Clinical Medicine, Beijing Shijitan Hospital, Capital Medical University.

Abstract: Menstruation is an important indicator of women's health. Identification of abnormal menstrual patterns in adolescence may improve early diagnosis of potential health concerns in adulthood. This study aimed to evaluate menstrual patterns and disorders of Chinese women of reproductive age based on an APP. Read More

J Manipulative Physiol Ther 2021 Apr 17. Epub 2021 Apr 17.

Health, RAND Corporation, Santa Monica, California.

Objective: The purpose of this article is to discuss a literature review-a recent systematic review of nonmusculoskeletal disorders-that demonstrates the potential for faulty conclusions and misguided policy implications, and to offer an alternate interpretation of the data using present models and criteria.

Methods: We participated in a chiropractic meeting (Global Summit) that aimed to perform a systematic review of the literature on the efficacy and effectiveness of mobilization or spinal manipulative therapy (SMT) for the primary, secondary, and tertiary prevention and treatment of nonmusculoskeletal disorders. After considering an early draft of the resulting manuscript, we identified points of concern and therefore declined authorship. Read More

J Minim Invasive Gynecol 2021 Apr 17. Epub 2021 Apr 17.

Hospital Israelita Albert Einstein, São Paulo, Brazil.

Objective: To show the challenging diagnosis and safe robotic surgical approach of a rare case of disseminated peritoneal leiomyomatosis (DPL).

Design: A clinical case shown by a sequential demonstration of investigation, diagnosis and surgical approach, with narrated video footage.

Setting: DPL is a rare disease, with just over 150 cases reported in literature. Read More