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Sci Rep 2019 Feb 18;9(1):2194. Epub 2019 Feb 18.

Department of Obstetrics and Gynecology, NorthShore University HealthSystem, Evanston IL, 60201, USA.

Menstrual pain, also known as dysmenorrhea, is a leading risk factor for bladder pain syndrome (BPS). A better understanding of the mechanisms that predispose dysmenorrheic women to BPS is needed to develop prophylactic strategies. Abnormal autonomic regulation, a key factor implicated in BPS and chronic pain, has not been adequately characterized in women with dysmenorrhea. Read More

BMC Womens Health 2019 Feb 18;19(1):35. Epub 2019 Feb 18.

Department of Obstetrics and Gynaecology, The First Affiliated Hospital of Wenzhou Medical University, Nanbaixiang, Street, Ouhai District, Wenzhou, Zhejiang Province, 325000, People's Republic of China.

Background: Until now, no previous study has addressed the menstrual patterns among female international students in China. In this present study, our objectives are to ascertain the menstrual characteristics and address the menstrual problems together with their associated risk factors among international students in China.

Methods: A cross-sectional survey was carried out with 500 previously piloted self-structured questionnaires which were administered to female international students enrolled in 15 universities in Zhejiang Province, China from May 2-August 31, 2016. Read More

Int J Reprod Biomed (Yazd) 2018 Nov;16(11):665-678

Department of Epidemiology and Reproductive Health, Reproductive Epidemiology Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran.

Background: Understanding the prevalence of menstrual disorders has important implications for both health service planning and risk factor epidemiology.

Objective: The aim of this review is to identify and collate studies describing the prevalence of menstrual disorders in Iran.

Materials And Methods: Studies with original data related to the prevalence of menstrual disorders were identified via searching six electronic databases and reviewing citations. Read More

Prz Menopauzalny 2018 Dec 31;17(4):141-143. Epub 2018 Dec 31.

3 Chair and Department of Gynaecology, Medical University of Lublin, Lublin, Poland.

Uterine fibroids are considered to be the most common benign tumours in females. The vast majority of these tumours are incidental findings and do not require any treatment. Symptomatic fibroids, with ailments such as abnormal uterine bleeding, dysmenorrhoea, pelvic pain, impaired urination, bowel dysfunction, infertility, and recurrent pregnancy loss, are indicated for medical treatment. Read More

Neuroreport 2019 Feb 11. Epub 2019 Feb 11.

Department of Acupuncture and Tuina, Chengdu University of Traditional Chinese Medicine.

Neuroimaging studies have manifested functional abnormalities in pain-related brain regions in patients with primary dysmenorrhea (PDM). However, as the key region in brain pain matrix, whether and how the amygdala functional network alteration in PDM is unclear. In this study, we aimed to investigate the intrinsic amygdala functional connectivity (AFC) network alteration in patients with PDM during ovulatory period. Read More

Int Braz J Urol 2019 Jan 25;45. Epub 2019 Jan 25.

Department of Gynae-Oncology, Asian Cancer Institute, Mumbai, India.

We demonstrate robot assisted radical nephrectomy with hysterectomy in the same sitting position followed by specimen retrieval per vagina (NOSE- Natural Orifice Specimen Extraction) A 36 year old female P2L2, presented with long standing dysmenorrhoea. Abdominal sonography detected incidental large left renal mass with a large fundal fibroid. CT scan revealed 8cmx8cm mass arising from mid and lower zone of the left kidney without vascular invasion and lymphadenopathy with a large fundal fibroid. Read More

Niger J Clin Pract 2019 Feb;22(2):174-180

Department of Chemical Pathology, College of Medicine, University of Ibadan, Ibadan, Nigeria.

Introduction: Oxidative stress has been associated with primary dysmenorrhea, but studies that have assessed multiple markers of peroxidation are scarce. This study investigated malondialdehyde (MDA), nitrotyrosine (3-NT), and protein carbonyls (PrCarb) as markers of oxidative stress and antioxidant status by serum alpha tocopherol level in young Nigerian women with dysmenorrhea.

Materials And Methods: In a case-control design, 45 female undergraduates who had had regular menses for at least six previous cycles were recruited consecutively from a university clinic as cases and 45 apparently healthy age-matched counterparts in their hall of residences as controls. Read More

Gynecol Endocrinol 2019 Feb 6:1-3. Epub 2019 Feb 6.

a Department of Gynecology and Gynecological Oncology, Gynecologic Cancer Unit Comprehensive Cancer Center Medical University of Vienna, Vienna , Austria.

In this case report, we present a case of false positive CA 19-9 and CA 125 levels in a patient with suspected endometriotic cysts. The patient is a 34-year-old nulliparous woman with heavy black tea consumption and elevated CA 19-9 and CA 125 levels. After discontinuation of black tea intake and careful exploration of other possible factors, CA 19-9 and CA 125 levels dropped markedly. Read More

J Comp Eff Res 2019 Feb 6. Epub 2019 Feb 6.

Center for Endometriosis Research & Treatment, University of California, San Diego, La Jolla, CA 92037, USA.

Aim: To assess the cost-effectiveness of elagolix versus leuprolide acetate in women with moderate to severe endometriosis pain.

Methods: A Markov model was developed. The efficacy of leuprolide acetate was derived from statistical prediction models using elagolix trial data. Read More

Pain 2019 Jan 31. Epub 2019 Jan 31.

Pediatric Pain and Palliative Care Program David Geffen School of Medicine at UCLA 10833 Le Conte Ave., 22-464 MDCC Los Angeles, CA 90095-1752 United States of America Phone: (310) 825-6953 Fax: (310) 794-2104

Primary dysmenorrhea (PD; menstrual pain without an underlying medical condition) is associated with enhanced pain sensitivity and temporal summation in adult women, which may reflect the presence of central pain processes. Research in this area has been limited by focusing on only adult populations and incomplete assessments of central sensitization. The current study explored both excitatory and inhibitory measures of pain processing in girls and young adult women with and without PD. Read More

Medicine (Baltimore) 2019 Feb;98(5):e14170

Department of Korean Medicine Obstetrics & Gynecology, College of Korean Medicine, Kyung Hee University, Seoul, South Korea.

Background: Primary dysmenorrhea is a condition characterized by painful menstrual cramps that usually occurs in the absence of any identifiable pathological condition among menstruating women, with the prevalence estimates varying between 45% and 95%. Nonsteroidal anti-inflammatory drugs (NSAIDs) are considered as a standard treatment for primary dysmenorrhea; however, the failure rate of NSAIDs is often 20% to 25% and these drugs commonly cause adverse effects. In this review, we investigated the current evidence related to the effectiveness of Xuefu Zhuyu decoction (XZD) or Hyeolbuchukeo-tang, a traditional herbal formula, as a treatment for primary dysmenorrhea. Read More

Med Hypotheses 2019 Feb 21;123:50-54. Epub 2018 Dec 21.

Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hung Hom, Hong Kong.

The popular accepted explanation for the pathogenesis of primary dysmenorrhea is elevated levels of uterine prostaglandins. Aetiological studies report that production of prostaglandins is controlled by the sex hormone progesterone, with prostaglandins and progesterone displaying an inverse relationship (i.e. Read More

Minerva Ginecol 2019 Jan 28. Epub 2019 Jan 28.

3 Unit of Gynecology and Human Reproduction Physiopathology, Department of Obstetrics and Gynecology, S. Orsola Hospital, University of Bologna, Bologna, Italy.

Dysmenorrhea and chronic pelvic pain occur in a significantly higher percentage in women with endometriosis; this benign condition has an incidence ranging from 5 to 10% in the general population, while 35% to 50% of infertile women are affected. Treatment of the symptoms demands integrated approaches with the use of anti-inflammatory substances or drugs and lifestyle changes, including attention to diet. The use of traditional anti-inflammatory drugs over the long term is not very successful because of the fear of side effects so they are almost always used with a short-term formula of 7-10 days when the woman's general condition becomes difficult to bear. Read More

J Bodyw Mov Ther 2019 Jan 2;23(1):94-98. Epub 2018 Feb 2.

Consultant Laparoscopic Surgeon, RMV Hospital, Bangalore, India.

Background: Abdominal wall pain is considered as pain that arises from the abdominal muscles rather than the underlying viscera or the spine. It is frequently overlooked and is often misdiagnosed, as these patients continue to suffer with pain. Many such patients would have even been subjected to a psychiatric evaluation in view of the absence of any ostensible clinical cause for the pain. Read More

J Sep Sci 2019 Jan 23. Epub 2019 Jan 23.

Innovation Center of Chinese Medicine, China State Institute of Pharmaceutical Industry, Shanghai, P. R. China.

The Wen-Jing decoction, a traditional Chinese medicine formula, has been used as a blood-activating and stasis-eliminating drug to treat gynaecological syndromes, such as dysmenorrhea, amenorrhea, and menstrual disorders. However, its pharmacodynamic material basis and mechanism of action have not been thoroughly elucidated to date. The goal of this study was to characterize and identify multiple constituents and metabolites in Wen-Jing decoction. Read More

Colorectal Dis 2019 Jan 23. Epub 2019 Jan 23.

Royal Liverpool and Broadgreen University Hospital NHS Trust, Liverpool, United Kingdom.

Trans anal endoscopic microsurgery (TEMS) is a recognized technique for treating benign rectal polyps and early rectal cancer. We report that TEMS is a treatment option for rectal endometriosis [1,2]. A 35 year old otherwise healthy nulliparous lady presented with cyclical dyschezia, chronic pelvic pain, severe dysmenorrhea and rectal bleeding. Read More

Obstet Gynecol Sci 2019 Jan 27;62(1):1-10. Epub 2018 Dec 27.

Department of Obstetrics and Gynecology, Fertility Center of CHA Gangnam Medical Center, CHA University School of Medicine, Seoul, Korea.

Endometriosis is a chronic inflammatory condition that affects fertility and could be toxic to the ovary. Endometrioma per se and surgical interventions for endometrioma significantly reduce the ovarian reserve. Therefore, to prepare for surgical intervention for endometrioma, the high-risk group with decreased ovarian reserve must be considered. Read More

Complement Ther Med 2019 Feb 13;42:438-444. Epub 2018 Nov 13.

Tübingen University Children´s Hospital, Germany; Dept of Pediatrics, Filderklinik, Filderstadt, Germany; Chair of Medical Theory, Integrative and Anthroposophic Medicine, Witten/Herdecke University, Germany.

Background: 20-90% of all women suffer from dysmenorrhea. Standard therapy of primary dysmenorrhea (PD) are NSAIDs and oral contraceptives, effective but not without possible side effects.

Objective: To examine the efficacy of rhythmical massage (Anthroposophic Medicine) and heart rate variability biofeedback compared to usual care (control group) on pain intensity in women with primary dysmenorrhea. Read More

Reprod Sci 2019 Jan 22:1933719118820469. Epub 2019 Jan 22.

1 Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China.

Background:: This study aimed to investigate potential factors, especially early-life exposures, associated with endometrioma (OMA) and/or deep infiltrating endometriosis (DIE) in Chinese women.

Methods:: This is a subgroup analyses of the FEELING study, which was a case-control study that investigated the clinical, lifestyle, and environmental factors associated with OMA and/or DIE in China, Russia, and France. In this subgroup analysis, the data for the Chinese participants were further analyzed using logistic regression model. Read More

Gynecol Endocrinol 2019 Jan 22:1-4. Epub 2019 Jan 22.

c Department of Cardio-Thoracic and Respiratory Science , University of Campania "Luigi Vanvitelli ," Naples , Italy.

Introduction: The link between obesity epidemic in fertile age and fertility reduction, in relation with BMI increase, has been demonstrated. An inverse proportionality between BMI and anti-Müller hormone (AMH) has been investigated. This hormone is strictly related to ovarian function. Read More

Eur J Contracept Reprod Health Care 2019 Jan 21:1-10. Epub 2019 Jan 21.

a Department of Medical and Surgical Sciences for Mothers, Children and Adults , University of Modena and Reggio Emilia, Azienda Ospedaliero Universitaria Policlinico , Modena , Italy.

Objective: A systematic review was carried out of studies of women with endometriosis, to examine the evidence for efficacy of the use of hormonal contraception to improve disease-related pain and decrease postoperative risk of disease recurrence.

Methods: A search of the Medline/PubMed and Embase databases was performed to identify all published English language studies on hormonal contraceptive therapies (combined hormonal contraceptives [CHCs], combined oral contraceptives [COCs], progestin-only pills [POPs] and progestin-only contraceptives [POCs]) in women with a validated endometriosis diagnosis, in comparison with placebo, comparator therapies or other hormonal therapies. Main outcome measures were endometriosis-related pain (dysmenorrhoea, pelvic pain and dyspareunia), quality of life (QoL) and postoperative rate of disease recurrence during treatment. Read More

Eur J Pain 2019 Jan 21. Epub 2019 Jan 21.

Department of Medical Imaging, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.

Background: Primary dysmenorrhoea (PDM), characterized as menstrual pain without pelvic pathology, is associated with pain-related negative mood and hormone fluctuations. Previous studies strongly supported the link between pain and negative mood in affected individuals; however, it remains largely unknown in patients with PDM.

Methods: We focused on the effects how spontaneous pain, negative mood and hormone levels played on the central nervous system in 34 PDM women and 33 matched healthy controls across their cycles (periovulatory phase and menstruation phase) by using T1-weighted and functional imaging. Read More

BMC Complement Altern Med 2019 Jan 17;19(1):22. Epub 2019 Jan 17.

School of Science and Health, Western Sydney University, Sydney, Australia.

Background: Menstrual pain is very common amongst young women. Despite the significant impact that menstrual pain has on academic attendance and performance, social activities and quality of life, most young women do not seek medical treatment but prefer to use self-care; commonly OTC analgesic medications and rest. Many women do not get significant pain relief from these methods, therefore other low cost, easy to learn self-care methods may be a valuable approach to management. Read More

J Womens Health (Larchmt) 2019 Feb 16;28(2):162-169. Epub 2019 Jan 16.

1 Vanderbilt-Meharry Center of Excellence in Sickle Cell Disease, Vanderbilt University Medical Center, Nashville, Tennessee.

Background: Acute vaso-occlusive pain episodes in sickle cell disease (SCD) are associated with increased rates of hospitalization and early mortality. Despite the observation that women have higher rates of acute vaso-occlusive pain episodes than men, sex-specific risk factors for acute vaso-occlusive pain have not been identified. We tested the hypothesis that acute vaso-occlusive pain is temporally associated with the onset of menstruation in women with SCD. Read More

BMC Complement Altern Med 2019 Jan 15;19(1):17. Epub 2019 Jan 15.

NICM Health Research Institute, Western Sydney University, Building 5, Campbelltown Campus, Locked Bag 1797, Penrith, Sydney, NSW, 2751, Australia.

Background: Endometriosis has a significant negative impact on the lives of women, and current medical treatments often do not give sufficient pain relief or have intolerable side effects for many women. The majority of women with primary dysmenorrhea use self-management strategies (including self-care techniques or lifestyle choices) to help manage period related symptoms, but little is known about self-management in women with endometriosis. The aim of this survey was to determine the prevalence of use, safety, and self-rated effectiveness of common forms of self-management. Read More

Indian J Pediatr 2019 Jan 12;86(Suppl 1):25-33. Epub 2019 Jan 12.

Unit of Biostatistics, Epidemiology Public Health, Department of Cardiac, Thoracic, Vascular Science and Public Health, University of Padua, Padua, Italy.

Objective: This population-based study on school-aged girls aimed to estimate the rate of peri-menstrual headache, evaluate headache pain pattern during the menstrual cycle, and verify its relationships with physical, psychosocial and life-style factors.

Methods: The students (n = 4973) fulfilled a self-administered questionnaire on demographic and behavioral characteristics, menarche, menstrual pattern and features including headache and dysmenorrhea. The prevalence of headache and the mean pain intensity score at the three menstrual cycle phases (premenstrual, menstrual, in-between period) were estimated, both overall and by gynecological year. Read More

Int J Reprod Med 2018 2;2018:3806856. Epub 2018 Dec 2.

PhD, Professor, Department of Obstetrics and Gynecology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, SP, Brazil.

Aim: To evaluate the clinical features, diagnostic routine, treatment, and prognosis of patients with double uterus with obstructed hemivagina and ipsilateral renal agenesis at a University Hospital.

Methods: A retrospective study analyzing the medical charts of outpatients with similar complex genital malformations seen at the University Hospital of the Ribeirão Preto Medical School from 1994 to 2015.

Results: Fourteen patients were included in this retrospective study, all presenting with double uterus with obstructed hemivagina and ipsilateral renal agenesis. Read More

Gynecol Obstet Invest 2019 Jan 10:1-16. Epub 2019 Jan 10.

Department of Midwifery, School of Nursing and Midwifery, Qazvin University of Medical Sciences, Qazvin, Iran.

Background: The incidence and severity of primary dysmenorrhea are influenced by various factors. The aim of the present study was to review nutritional factors influencing primary dysmenorrhea.

Methods: Academic databases including Web of Science, EMBASE, Scopus, and PubMed (including Medline) were searched using keywords of nutrition, diet, and primary dysmenorrhea. Read More

Indian J Pediatr 2019 Jan 10;86(Suppl 1):34-41. Epub 2019 Jan 10.

Unit of Biostatistics, Epidemiology and Public Health, Department of Cardiac, Thoracic, Vascular Science and Public Health, University of Padua, Padua, Italy.

Objective: To explore the independent role of age at menarche on menstrual abnormalities among adolescents.

Methods: The present study was a multicenter cross-sectional study on a large sample (n = 3782) of Italian girls aged 13-21 y attending secondary school who already had menarche. Girls were asked to fill in a questionnaire on menarcheal age and menstrual features during the latest three menses. Read More

Diseases 2019 Jan 8;7(1). Epub 2019 Jan 8.

Department of Endocrinology-Diabetes and Metabolism, Naval Hospital of Athens, 11521 Athens, Greece.

Dysmenorrhea (pain during menstruation) is one of the most common medical conditions among women of reproductive age. Dysmenorrhea has been studied around the world but not yet in Greece. The aim of the present study was to investigate the prevalence, characteristics, and impact of dysmenorrhea on the wellbeing (exercising, and social and academic functioning) among nursing students in Greece. Read More

Postepy Dermatol Alergol 2018 Dec 13;35(6):631-635. Epub 2018 Nov 13.

Department of Physiology and Immunology, Medical Faculty, University of Prishtina, Prishtina, Kosovo.

Introduction: Hirsutism is defined as excess terminal hair that commonly appears in a male pattern in women.

Aim: To examine severity and distribution of hirsutism with Ferriman-Gallwey visual scoring system in hirsute women in Kosovo.

Material And Methods: This prospective study included 160 women, 135 with hirsutism and 25 as a control group. Read More

Med Sci Monit 2019 Jan 6;25:157-164. Epub 2019 Jan 6.

Department of Emergency Medicine, Pamukkale University, Medical Faculty, Denizli, Turkey.

BACKGROUND NSAIDs are the most common agents used in dysmenorrhea treatment. They reduce menstrual pain by reducing uterine pressure and PGF2alpha levels in the menstrual fluid. The aim of this study was to compare the effects of piroxicam and diclofenac sodium as treatments for primary dysmenorrhea. Read More

Eur J Obstet Gynecol Reprod Biol 2019 Feb 17;233:114-119. Epub 2018 Dec 17.

Department of Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran; Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address:

Objective: Premenstrual syndrome (PMS), primary dysmenorrhea (PD), and irritable bowel syndrome (IBS) are common complaints in women of reproductive age. Trace element status may be associated with the development of these disorders but the current data are unclear. The present study focused on the relationship between serum and dietary copper and zinc with some common physical and psychosomatic conditions among young females. Read More

J Pain Res 2018 13;11:3181-3194. Epub 2018 Dec 13.

School of Medicine, University of Adelaide, Adelaide, SA, Australia.

Purpose: Dysmenorrhea is a common disorder that substantially disrupts the lives of young women. The frequency of 14 associated symptoms both within and outside the pelvis was determined.

Patients And Methods: Symptom questionnaires were completed by 168 women with dysmenorrhea, allocated to three groups based on their diagnostic status for endometriosis confirmed (Endo+), endometriosis excluded (Endo-), or endometriosis diagnosis unknown (No Lap). Read More

Expert Opin Ther Pat 2019 Feb 15;29(2):115-126. Epub 2019 Jan 15.

a Postgraduate Program in Biotechnology - RENORBIO , Focal Point - Federal University of Piauí , Teresina , Brazil.

Introduction: Primary dysmenorrhea (PD) is another term for idiopathic menstrual cramps. Treatments include the use of oral non-steroidal anti-inflammatory drugs (NSAIDs). These drugs have several side effects. Read More

Evid Based Complement Alternat Med 2018 21;2018:8791538. Epub 2018 Nov 21.

College of Health Preservation and Rehabilitation, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China.

Objectives: As current evidence of the effectiveness on acupuncture for primary dysmenorrhea (PD) is inconsistent, we aimed to critically appraise the evidence from relevant systematic reviews (SRs).

Methods: SRs of randomized controlled trials (RCTs) concerning acupuncture and PD were searched in four databases. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) and latest Assessment of Multiple Systematic Reviews 2 (AMSTAR2) checklists were used to assess reporting characteristics and methodological quality, respectively. Read More

Evid Based Complement Alternat Med 2018 15;2018:3752723. Epub 2018 Nov 15.

College of Korean Medicine, Dongguk University, Goyang 10326, Republic of Korea.

Background: It has been known that acupuncture treatment relieves gynecological disorders such as menopause, ovarian dysfunction, and dysmenorrhea. Sex hormones, including estrogen, progesterone, and gonadotropins, are related to the women disease. However, regulative effect of acupuncture on sex hormones has not been fully identified. Read More

Nat Prod Res 2018 Dec 23:1-5. Epub 2018 Dec 23.

a College of Xiangya Pharmaceutical Science , Central South University , Changsha , Hunan , China.

The pollen of T. angustifolia, also known as Pu huang in Chinese, has been used for treatment of stranguria, hematuria, dysmenorrhea, metrorrhagia and injuries in China for a long time. Extensive efforts have been directed toward its phytochemical and biological aspects. Read More

Sci Rep 2018 Dec 21;8(1):18019. Epub 2018 Dec 21.

Department of Orthopedic Surgery, Keio University School of Medicine, 35 Shinano-machi, Shinjuku-ku, Tokyo, 160-8582, Japan.

Stress fractures are a limitation for athletes not only in sports performance but in activities of daily living. Thus, preventing them is crucial. In female athletes, a triad of symptoms including low energy availability, functional hypothalamic amenorrhea and osteoporosis are considered risk factors for stress injuries, but biomarkers predictive of these outcomes are not available. Read More

Ned Tijdschr Geneeskd 2018 Dec 5;163. Epub 2018 Dec 5.

Viecuri Medisch Centrum, afd. Gynaecologie, locatie Venlo.

A 31-year-old woman presented at the fertility department with primary subfertility since one year. Last year she had had progressive dysmenorrhea and pain in her right leg and groin during her menstrual period. MRI showed extensive pelvic endometriosis with a lesion in the right round ligament in the inguinal canal. Read More

Semin Reprod Med 2018 Mar 19;36(2):116-122. Epub 2018 Dec 19.

Department of Obstetrics and Gynecology, University of Michigan Health System, Ann Arbor, Michigan.

Dysmenorrhea and noncyclic pelvic pain (chronic pelvic pain) are common in adolescents. The evaluation of teens with dysmenorrhea or chronic pelvic pain is aimed to diagnose possible gynecologic conditions (endometriosis, pelvic inflammatory disease, ovarian cysts, and obstruction of the reproductive tract) and nongynecologic conditions (irritable bowel syndrome, interstitial cystitis, and myofascial pain). The management of chronic pelvic pain in adolescents is often more complex than in adult women because both the adolescent and her parents are counseled and addressed, and her long-term emotional and physical health, fertility, and sexuality are considered. Read More

Endocrinology 2019 Mar;160(3):605-625

Hudson Institute of Medical Research, Clayton, Victoria, Australia.

This mini-review summarizes key points from the Clark Sawin Memorial Lecture on the History of Estrogen delivered at Endo 2018 and focuses on the rationales and motivation leading to various discoveries and their clinical applications. During the classical period of antiquity, incisive clinical observations uncovered important findings; however, extensive anatomical dissections to solidify proof were generally lacking. Initiation of the experimental approach followed later, influenced by Claude Bernard's treatise "An Introduction to the Study of Experimental Medicine. Read More

Pak J Med Sci 2018 Nov-Dec;34(6):1478-1482

Dr. Elvan Yilmaz Akyuz Assistant Professor Department of Nutrition and Dietetics, Faculty of Health Sciences, University of Health Sciences, Istanbul, Turkey.

Objective: To evaluate the effect of diet therapy on primary dysmenorrhea in female university students.

Methods: A randomized controlled pre and post-test design was used to verify the effects of diet therapy on primary dysmenorrhea. The study was conducted on 67 female students who were suffering from primary dysmenorrhea. Read More

Food Funct 2019 Jan;10(1):244-249

Department of Obstetrics and Gynecology, Shandong University QiLu Hospital, 104 culture west Road, Jinan 250012, Shandong, China.

To investigate the effects and the underlying mechanisms of ginsenoside Rf in a surgically induced rat endometriosis model, endometriosis was constructed through homologous transplantation and the Wistar rats were further randomly classified into the sham group, the estradiol valerate (E2V) control group, the endometriosis group, and the ginsenoside Rf groups (1.0, 2.0 and 4. Read More

Taiwan J Obstet Gynecol 2018 Dec;57(6):806-809

Department of Midwifery, Babol University of Medical Sciences, Babol, Islamic Republic of Iran.

Objective: Menstrual pain is a periodic pain which happens during the days of menses. The menstrual disturbances as a health problem among young girls affect not only reproductive, but also psychical health and quality of life. This study was done with the goal of comparing the effect of Ginger and Novafen on the menstrual pain. Read More

Front Neurosci 2018 20;12:826. Epub 2018 Nov 20.

Institute of Brain Science, National Yang-Ming University, Taipei, Taiwan.

The irregularity and uncertainty of neurophysiologic signals across different time scales can be regarded as neural complexity, which is related to the adaptability of the nervous system and the information processing between neurons. We recently reported general loss of brain complexity, as measured by multiscale sample entropy (MSE), at pain-related regions in females with primary dysmenorrhea (PDM). However, it is unclear whether this loss of brain complexity is associated with inter-subject genetic variations. Read More

Arq Bras Cir Dig 2018 Dec 6;31(4):e1406. Epub 2018 Dec 6.

Medical School, University of Southern Santa Catarina, Palhoça.

Background: Deep infiltrating colorectal endometriosis may severely affect the quality of life and fertility of patients. Although segmental resection is a therapeutic option that provides positive outcomes in the management of symptoms, its functional effects are still unproven.

Aim: Assess the late impact of the laparoscopic approach in treating deep infiltrating endometriosis with segmental colorectal resection. Read More

Cytojournal 2018 12;15:27. Epub 2018 Nov 12.

Address: Department of Obstetrics and Gynecology, Shiga University of Medical Science, Seta, Otsu, Shiga, Japan.

Background: Mast cells are observed in peritoneal endometriosis which causes dysmenorrhea. However, there is no report about the relationship between endocervical mast cells and dysmenorrhea. The aim of this study is to evaluate the relationship using endocervical smears. Read More

Obstet Gynecol 2019 Jan;133(1):63-70

Department of Obstetrics and Gynecology, University of Colorado, Aurora, Colorado; the Department of Obstetrics and Gynecology, University of Utah, Salt Lake City, Utah; the Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh, Magee-Womens Research Institute, Pittsburgh, Pennsylvania; the Department of Obstetrics and Gynecology, Eastern Virginia Medical School, Norfolk, Virginia; Medicines360, San Francisco, California; and the Department of Obstetrics and Gynecology, University of California, Davis, Sacramento, California.

Objective: To assess the 5-year contraceptive efficacy and safety of a levonorgestrel (LNG) 52-mg intrauterine system (IUS) from an ongoing 10-year phase 3 contraceptive trial.

Methods: Study investigators enrolled 1,751 nulliparous and parous females aged 16-45 years and desiring contraception to receive a novel LNG 52-mg IUS at 29 centers in the United States, including reproductive health clinics, private offices, and university centers. Participants had scheduled follow-up visits four times during the first year. Read More

PLoS One 2018 6;13(12):e0206053. Epub 2018 Dec 6.

Department of Gynecological Endocrinology and Fertility Disorders, University of Heidelberg, Heidelberg, Germany.

Background: Local anesthetics (LAs) are increasingly used as therapeutics due to their multiple molecular effects. They may be potential agents also in gynecology and reproductive medicine. The objective of this study was to investigate the contractility response of the perfused swine uterus to different concentrations of the LAs procaine, lidocaine, and ropivacaine. Read More