Indian J Pharmacol 2017 Nov-Dec;49(6):470-471
Department of Dermatology, Nicolina Medical Centre, Apollonia University, "P.Poni" Research Institute of Macromolecular Chemistry, Lasi, Romania.
We present first case report on itraconazole, a drug very commonly used for onychomycosis, used along with simvastatin that caused metrorrhagia. The suggested probable mechanism is the inhibition of steroidogenesis, especially estrogens that resulted in low-estrogen breakthrough bleeding. This article emphasizes the importance of drug interaction check prior the initiation of onychomycosis treatment. Read More