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Med J Malaysia 2022 May;77(3):374-383

Mahsa University, Jalan SP2, Bandar Saujana Putra, Jenjarom, Kuala Langat, Selangor, Malaysia.

Abnormal uterine bleeding (AUB) is one of the commonest complaints of women in reproductive age and non-gravid state that brings them to the attention of the primary care doctor or the gynaecologist. Anovulation without any medical illness or pelvic pathology seems to be the common cause. Bleeding due to a wide variation in pathology both inside and outside the reproductive tract can be termed as anovulatory bleeding. Read More

Int J Surg Case Rep 2022 Jun 13;95:107195. Epub 2022 May 13.

Gynaecology-Obstetrics and Endoscopy Department, Maternity Souissi, University Hospital Center IBN SINA, University Mohammed V, Rabat, Morocco.

Background: Ectopic pregnancies are a dreaded and common cause of first-trimester metrorrhagia. They refer to the implantation and development of the embryo outside the uterine cavity. Interstitial localization is uncommon and corresponds to implantation of the embryo in the intramural part of the uterine tube. Read More

J Pharm Biomed Anal 2022 Aug 10;217:114828. Epub 2022 May 10.

Department of Pharmacy, Anhui University of Chinese Medicine, Hefei 230012, PR China; Institute of Traditional Chinese Medicine Resources Protection and Development, Anhui Academy of Chinese Medicine, Hefei 230012, PR China; Anhui Province Key Laboratory of Chinese Medicinal Formula, Anhui Academy of Chinese Medicine, Hefei 230012, PR China.

Clinopodium chinense (Benth.) O. Kuntze (C. Read More

Molecules 2022 May 6;27(9). Epub 2022 May 6.

KM Science Research Division, Korea Institute of Oriental Medicine, Daejeon 34054, Korea.

Oncheong-eum (OCE) is a traditional herbal prescription made by combining Samul-tang and Hwangryunhaedok-tang. It is primarily used to treat gynecological disorders such as metrorrhagia and metrostaxis. In the present study, we focused on developing and validating a simultaneous assay for the quality control of OCE using 19 marker components (gallic acid, 5-(hydroxymethyl)furfural, chlorogenic acid, geniposide, coptisine chloride, jatrorrhizine chloride, paeoniflorin, berberine chloride, palmatine chloride, ferulic acid, nodakenin, benzoic acid, baicalin, benzoylpaeoniflorin, wogonoside, baicalein, wogonin, decursin, and decursinol angelate). Read More

Curr Probl Pediatr Adolesc Health Care 2022 05 4;52(5):101185. Epub 2022 May 4.

Division of Adolescent Medicine, Cohen Children's Medical Center, Northwell Health, 410 Lakeville Road, Suite 108, New Hyde Park, New York, USA; Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, New York, USA.

Abnormal uterine bleeding (AUB) is a common diagnosis in the adolescent female population. In recent years, changes have been made to standardize nomenclature, evaluation and management of AUB in adolescents. The terms "abnormal uterine bleeding" and "heavy menstrual bleeding" have replaced terms including "dysfunctional uterine bleeding," "menorrhagia," "metrorrhagia", and "menometrorrhagia. Read More

FP Essent 2022 04;515:20-25

Department of Family Medicine - University of California San Diego School of Medicine, 402 Dickinson St, San Diego, CA 92103.

(AUB) is the term used to describe uterine bleeding that varies from the normal parameters of menstruation. This term replaces several previously used terms with less clear or conflicting definitions, including , , and . PALM-COEIN is a classification system for the etiologies of AUB in nongravid menstruating women. Read More

Semin Diagn Pathol 2022 May 22;39(3):228-237. Epub 2022 Mar 22.

Department of Pathology, UT Southwestern Medical Center, 5200 Harry Hines Blvd, Room 02-621 Dallas, TX, 75235, USA. Electronic address:

Gestational trophoblastic disease (GTD) is a heterogeneous group of lesions that are characterized by the abnormal proliferation of the trophoblast. Morphology, behavior and clinical significance vary tremendously and range from benign, non-neoplastic lesions that cause sometimes dysfunctional uterine bleeding to aggressive, highly, malignant tumors. The recently updated 2020 World Health Organization (WHO) Classification of Female Genital Tumors divides GTD in molar pregnancies/ hydatidiform moles, gestational trophoblastic neoplasms, tumor-like lesions and abnormal (nonmolar) villous lesions. Read More

Turk J Obstet Gynecol 2022 Mar;19(1):81-86

Koç University School of Medicine, Department of Obstetrics and Gynecology, İstanbul, Turkey.

Endometrial metastasis from the lung primary remains is rare. Moreover, the literature only contains case reports of endometrial metastasis from the primary lung cancer. An 83-year-old female patient presented with postmenopausal uterine bleeding and anemia. Read More

J Pediatr Adolesc Gynecol 2022 Mar 15. Epub 2022 Mar 15.

Department of Gynecology, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.

Background: Infantile hemangiomas are vascular anomalies. However, they rarely cause genital bleeding. Here, we present the case of a young female with an endocavitary hemangioma who presented with abnormal uterine bleeding (AUB). Read More

Gynecol Endocrinol 2022 Apr 3;38(4):345-349. Epub 2022 Mar 3.

National Children's Medical Center, Children's Hospital of Fudan University, Shanghai, PR China.

Objective: To observe and compare the expression of energy regulators (leptin/ghrelin) and PAI-1 in girls with abnormal uterine bleeding-ovulatory dysfunction (AUB-O) and healthy adolescent girls.

Methods: A total of 80 adolescent girls were studied including 60 with AUB-O and 20 healthy girls. All the general characteristics of subjects including height, weight, age, and age at menarche were collected after consent. Read More

Pak J Pharm Sci 2022 Jan;35(1(Special)):387-392

The 970th Hospital of the Joint Logistic Support Force of the People's Liberation Army, Yantai City, Shandong Province, China.

To evaluate the clinical effect of Gongning granules combined with low-dose hormone therapy in pubertal dysfunctional uterine bleeding (PDUB) and its effect on uterine hemodynamics. A total of 164 PDUB patients who were treated in the gynecological outpatient department of our hospital from December 2018 to June 2020 were randomized into study group and control group, with 82 cases each. The control group received estrogen progesterone, and the study group received Gongning granules plus. Read More

Acta Obstet Gynecol Scand 2022 May 2;101(5):506-513. Epub 2022 Mar 2.

Department of Gynecology and Obstetrics, University of Copenhagen, Amager Hvidovre Hospital, Hvidovre, Denmark.

Introduction: In the attempt of a trial of labor after a cesarean section approximately one in 200 women experience a complete uterine rupture. As a complete uterine rupture is associated with an adverse perinatal outcome, data regarding subsequent pregnancies are needed to provide proper care and guidance to women with a complete uterine rupture when informing them of future possibilities. The objective of this study was to investigate the fetal and maternal outcomes in subsequent pregnancies after a complete uterine rupture. Read More

Zhen Ci Yan Jiu 2022 Feb;47(2):177-84

College of Acupuncture-moxibustion and Tuina, Shandong University of Traditional Chinese Medicine, Jinan 250014, China.

Objective: To explore the dominant indications and laws of acupoint compatibility of Yinbai (SP1) by using modern statistics and data mining techniques.

Methods: Literature about indications and acupoint prescriptions of SP1 published before October of 1949 were retrieved from books (5 edition) and , and those published from October 1 of 1949 to January of 2021 retrieved from databa-ses of CNKI, Wanfang, VIP, CBM, Web of Science and Pubmed by using key words of Yinbai (SP1),"Guilei"(),"Guiyan"() and Jing (Well)-point of Spleen Meridian, followed by screening the data and establishing a SQL Server database after standardized processing. Then, the descriptive analysis, clustering analysis and association rule analysis were conducted by using Gephi visualization software, SPSS Statistics 25. Read More

Int J Surg Case Rep 2022 Mar 18;92:106842. Epub 2022 Feb 18.

Department of Gynecology and Obstetrics, University Hospital Center Ibn Rochd, Casablanca 20100, Morocco; Faculty of Medicine and Pharmacy, Hassan II University of Casablanca, Casablanca, Morocco.

Introduction: Primary ovarian leiomyoma is a rare benign tumor of the ovary seen in women between 20 and 65 years old. Clinical, ultasonographic and tumor marker data remain the best preoperative approach currently available for ovarian tumours. Only pathological examination can establish the diagnosis. Read More

Womens Health (Lond) 2022 Jan-Dec;18:17455057221077577

Department of Clinical Pharmacy, Institute of Health, Jimma University, Jimma, Ethiopia.

Introduction: Abnormal uterine bleeding is any bleeding that deviates from normal menstruations. It differs in terms of frequency of bleeding, duration, and the pattern of bleeding during menstrual cycle or menopause. It is a major gynecological problem for medical visits among women in the reproductive aged group. Read More

Evid Based Complement Alternat Med 2022 2;2022:5200608. Epub 2022 Feb 2.

Key Laboratory of Protein Chemistry and Developmental Biology of Fish of Ministry of Education, Hunan Normal University, Changsha 410081, China.

Dysfunctional uterine bleeding, accompanied by endometrial hyperplasia (EH), is a common gynecological disease that seriously affects female physical and mental health. Some drugs have been prompted to cure the disease, but most medications have certain side effects and limitations. In the present study, we demonstrated an unexploited Chinese traditional medicine, a combination of , , and (SCS), which could be used for the treatment of EH and associated complications in rats. Read More

Pan Afr Med J 2021 7;40:208. Epub 2021 Dec 7.

Centre de Maternité et Néonatologie, Centre Hospitalier Universitaire Fattouma Bourguiba de Monastir, Monastir, Tunisie.

Ovarian pregnancy is a rare entity among ectopic pregnancies. Its diagnosis and management are not always easy. It is a particular pathology, the clinician is confronted with a poor clinical semiology and a difficult ultrasound diagnosis. Read More

Medicine (Baltimore) 2022 Feb;101(5):e28766

Gynaecology Department, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, China.

Abstract: Triptorelin is one of the most commonly used gonadotropin-releasing hormone agonists and has been used in the treatment of deep infiltrating endometriosis (DIE). This study aimed to evaluate the efficacy and safety of up to 24 weeks of triptorelin treatment after conservative surgery for DIE.This prospective, non-interventional study was performed in 18 tertiary hospitals in China. Read More

Reprod Sci 2022 04 2;29(4):1157-1169. Epub 2022 Feb 2.

Division of Gynecologic Endocrinology and Infertility, Department of Obstetrics and Gynecology, Severance Hospital, Yonsei University, Seoul, Republic of Korea.

Several clinical trials in women with endometriosis demonstrated that dienogest reduces endometrial lesions and improves health-related quality of life (HRQoL). To assess HRQoL in dienogest-treated patients in real-world setting, we conducted a prospective, non-interventional study in 6 Asian countries. Women aged ≥18 years with clinical or surgical diagnosis of endometriosis, presence of endometriosis-associated pelvic pain (EAPP) and initiating dienogest therapy were enrolled. Read More

Dermatol Ther 2022 04 15;35(4):e15352. Epub 2022 Feb 15.

Department of Dermatology, National Skin Centre, Singapore, Singapore.

J Gynecol Obstet Hum Reprod 2022 Mar 25;51(3):102326. Epub 2022 Jan 25.

Department of Obstetrics and Fetal Medicine at Necker-Enfants-Malades Hospital, 149 Rue de Sèvres, Paris 75015, France.

Background: Cesarean scar myometrial defect as known as niche is associated with postmenstrual spotting, suprapubic pain and secondary infertility. Hysteroscopic isthmoplasty has been proposed in the treatment of niche. This study aims to determine the safety and effectiveness of hysteroscopic isthmoplasty in postmenstrual spotting treatment and improvement of spontaneous conceiving. Read More

Ceska Gynekol 2021 ;86(6):392-396

Objective: Description of a case of extrapulmonary genital tuberculosis of the uterine cervix in a postmenopausal patient.

Case Report: A 66-year-old patient with a history of metrorrhagia, an ulcerated process in the area of the uterine cervix and vagina, with infiltration of parametria, serosanguinolent discharge and progressive cachectization was admitted to the oncogynecological center of the Hospital of České Budějovice, a.s. Read More

Medicina (B Aires) 2022 ;82(1):142-146

Departamento de Medicina, Hospital de Clínicas José de San Martín, Universidad de Buenos Aires, Argentina.

A 40-year-old woman was scheduled to receive chemotherapy for a high-risk common B-cell acute lymphoblastic leukemia (ALL), diagnosed 10 months earlier in the wake of lower limb bruising and petechiae, and metrorrhagia. At that time, she had thrombocytopenia and a normal transvaginal gynecological ultrasound. Upon admission, she complained of a 3-month history of incapacitating left groin pain radiated to the thigh, and right lower quadrant abdominal pain associated with diarrhea. Read More

Cureus 2022 Jan 11;14(1):e21120. Epub 2022 Jan 11.

Anesthesiology and Critical Care, Center Hospitalier Regional d'Orleans, Orleans, FRA.

Background Placenta abruptio (PA) remains a serious materno-fetal complication. According to progress realized in maternal-fetal medicine, we aimed to evaluate the diagnosis and management of PA and neonatal outcomes. Methods We conducted a retrospective study that involved all the patients that were diagnosed with PA in a tertiary maternity hospital between 2006 and 2013. Read More

Arch Gynecol Obstet 2022 04 10;305(4):1079-1088. Epub 2022 Jan 10.

Department of Obstetrics and Gynecology, Rheinlandklinikum Dormagen, Pelvic School Saarbrücken, Hohe Wacht 77, Dormagen, Germany.

Purpose: Supracervical as well as total hysterectomy are considered to improve postoperative sexuality as well as quality of life, but the benefit of supracervical hysterectomy (LSH) is impaired in up to 20 percent by postoperative spotting. The aim of this study was to analyze the influence of a conical excision of the cervical stump during supracervical hysterectomy on the postoperative spotting rate and its influence on sexuality and in turn quality of life.

Methods: 321 Patients who underwent a laparoscopic supracervical hysterectomy with conical excision (extended laparoscopic supracervical hysterectomy, eLSH, n = 166, Dormagen hospital) or with straight cervical resection (laparoscopic supracervical hysterectomy, LSH, n = 133, MIC Clinics Berlin) were included. Read More

Case Rep Cardiol 2021 24;2021:5450376. Epub 2021 Dec 24.

Department of Cardiology, United Health Services Hospitals, Wilson Regional Medical Center, NY, USA.

Background: Direct coronary embolism in the setting of oral contraceptive pill (OCP) use is a rare adverse effect. It is known for OCP to increase the risk of thrombosis; however, leading to an inferior ST elevated myocardial infarction (STEMI) due to an acute occlusive embolism is a rare entity. Coronary embolism occurs in about 3% of patients with acute coronary syndrome. Read More

J Obstet Gynaecol Can 2022 05 29;44(5):517-520. Epub 2021 Dec 29.

The Fertility Clinic, London Health Sciences Center, Department of Obstetrics and Gynecology, Schulich School of Medicine and Dentistry, Western University, London, ON.

We evaluated resectoscopic surgery for definitive diagnosis and long-term therapy in 16 symptomatic tamoxifen-treated women with breast cancer who presented with abnormal uterine bleeding and/or intrauterine anomalies. Seven pre-menopausal women had benign pre- and post-operative endometrial biopsy, and 4 had benign polyps. At a median of 7 years of follow-up (range 2-8 y), all remained amenorrheic. Read More

Cell Mol Biol (Noisy-le-grand) 2021 Nov 25;67(3):138-142. Epub 2021 Nov 25.

Chinese Medicine Hospital, Huangdao District, Qingdao, Intensive Care Unit, Qingdao, China.

Dysfunctional uterine bleeding is menstrual bleeding in abnormal volume, duration, or time, and it is a common problem in women. A wide range of drug therapies, with varying efficacy, is available for women with dysfunctional uterine bleeding. The use of herbal and traditional medicine is one of the ways to treat this disease, which has fewer side effects than chemical drugs. Read More

Fertil Steril 2022 03 8;117(3):583-592. Epub 2021 Dec 8.

Department of Obstetrics and Gynecology, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto, Japan.

Objective: To evaluate the efficacy and safety of 40-mg relugolix (REL) compared with those of leuprorelin (LEU) in women with endometriosis-associated pain.

Design: Phase 3, multicenter, randomized, double-blind, double-dummy, active-controlled study in Japanese patients.

Setting: Hospitals and clinics. Read More

Medicine (Baltimore) 2021 Dec;100(49):e28080

Shandong University of Traditional Chinese Medicine, Jinan, Shandong, China.

Background: Adenomyosis (AM) is a disease in which the endometrium (including glands and stroma) invades the myometrium and grows. The main clinical symptoms include menorrhagia, dysmenorrhea, chronic pelvic pain, metrorrhagia, and dyspareunia, which will seriously affect the physical and mental health of patients, and most of which occur in women of childbearing age. Acupuncture, as a special external treatment of Traditional Chinese medicine, has shown good effects in the treatment of adenomyosis. Read More