3,932 results match your criteria Dysfunctional Uterine Bleeding


Guizhi Fuling Capsule Exhibits Antidysmenorrhea Activity by Inhibition of Cyclooxygenase Activity.

Evid Based Complement Alternat Med 2020 23;2020:8607931. Epub 2020 May 23.

State Key Laboratory of New-Tech for Chinese Medicine Pharmaceutical Process, Jiangsu Kanion Pharmaceutical Co., Ltd., Lianyungang, Jiangsu 222001, China.

Guizhi Fuling capsule (GZFLc) is a modern preparation from traditional Chinese Medicine. Guizhi Fuling was first prescribed by Zhang Zhongjing almost two thousand years ago for the treatment of primary dysmenorrhea. It has also been used to treat uterine fibroids, dysfunctional uterine bleeding, and endometriosis. Read More

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http://dx.doi.org/10.1155/2020/8607931DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7262657PMC

Symptom related to Essure® and evolution after removal: outcomes of retrospective cohort.

J Gynecol Obstet Hum Reprod 2020 Jun 23:101836. Epub 2020 Jun 23.

CHU Lille, Gynaecological Surgery Department, F-59000, Lille, France. Electronic address:

Introduction: The number of requests for Essure removal has grown continually over recent years. The objective is to describe the symptoms reported after Essure sterilization, methods of removal and results.

Material And Methods: Retrospective and single-centre cohort (Regional university hospital of Lille, France) was conducted. Read More

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http://dx.doi.org/10.1016/j.jogoh.2020.101836DOI Listing

Adjuvant therapy of Chinese herbal medicine for the treatment of adenomyosis: A protocol for systematic review.

Medicine (Baltimore) 2020 Jun;99(25):e20560

Department of Gynecology, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu.

Background: Adenomyosis is benign gynecologic condition with complex etiologies. Common symptoms associated with adenomyosis (AM) include menorrhagia, dysmenorrhea, chronic pelvic pain, metrorrhagia, and dyspareunia. Although Chinese herbal medicine (CHM) has often been utilized for managing AM in clinical practice in China, evidence regarding its efficacy is lacking. Read More

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http://dx.doi.org/10.1097/MD.0000000000020560DOI Listing

Thyroid Dysfunction in Patients with Abnormal Uterine Bleeding in a Tertiary Care Hospital: A Descriptive Cross-sectional Study.

JNMA J Nepal Med Assoc 2020 May 30;58(225):333-337. Epub 2020 May 30.

Department of Obstetrics and Gynecology, KIST Medical College, Imadol, Nepal.

Introduction: Abnormal uterine bleeding is a common gynecological presentation, accounting for at least 20% of all new outpatient visits. It has been recognized that thyroid dysfunction may have profound effects on the female reproductive system. Both hypothyroidism and hyperthyroidism are associated with a variety of changes, including delayed onset of puberty, anovulatory cycles, and abnormally high fetal wastage. Read More

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http://dx.doi.org/10.31729/jnma.5033DOI Listing

Immunohistochemical results and case report of an incidental finding of uterine polypoid adenomyoma after long-time therapy for metrorrhagia.

Pathol Res Pract 2020 Jul 11;216(7):152998. Epub 2020 May 11.

II(ND) Department of Gynecology, Lublin Medical University, Lublin, Poland. Electronic address:

We present a 25-year-old female woman with a 9-year history of metrorrhagia, in whom a uterine polypoid adenomyoma (UPA) was incidentally detected. Intense nuclear staining in the uterine adenomyoma tissue showed an immunoreaction with BAF250a/ARID1A, Arginase-2 as well as 1LRH-2E1/NR5A2, suggesting a role of these proteins and transcriptional activity of their genes in uterine polypoid adenomyoma development. Neither Nidogen-2 nor SF-1/NR5A1 were expressed in UPA. Read More

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http://dx.doi.org/10.1016/j.prp.2020.152998DOI Listing

Network Pharmacology-Based Prediction of Active Ingredients and Potential Targets of ShengDiHuang Decoction for Treatment of Dysfunctional Uterine Bleeding.

Evid Based Complement Alternat Med 2020 11;2020:7370304. Epub 2020 May 11.

Shaanxi Key Laboratory of Traditional Chinese Medicine Foundation and New Drug Research, College of Pharmacy, Shaanxi University of Chinese Medicine, Xianyang 712046, China.

Objective: To analyze the potential active ingredients and related crucial targets of the ShengDiHuang Decoction (SDHD) formula in the treatment of dysfunctional uterine bleeding (DUB) by using network pharmacology and verification experiment.

Methods: In this study, we determined the potential active ingredients from the traditional SDHD formula and their targets with the network pharmacology method. The network of "compound-disease-target" was constructed by the software of Cytoscape. Read More

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http://dx.doi.org/10.1155/2020/7370304DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7240676PMC

Topical Tranexamic Acid for Hemostasis of an Oral Bleed in a Patient on a Direct Oral Anticoagulant.

Clin Pract Cases Emerg Med 2020 May 27;4(2):146-149. Epub 2020 Mar 27.

Yale School of Medicine, Department of Emergency Medicine, New Haven, Connecticut.

Introduction: Tranexamic acid (TXA) is an antifibrinolytic agent currently approved and utilized in the treatment of dysfunctional uterine bleeding, traumatic extracranial hemorrhage, anterior epistaxis, and dental procedures on patients with hemophilia. There is a paucity of literature evaluating the use of TXA for hemostasis in patients on direct oral anticoagulants (DOACs).

Case Report: Our patient, a 72 year-old male on rivaroxaban, presented with persistent bleeding following a punch biopsy of the buccal mucosa. Read More

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http://dx.doi.org/10.5811/cpcem.2020.1.45326DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7219988PMC

Shifting Valproic Acid to Levetiracetam in Women of Childbearing Age With Epilepsy: A Retrospective Investigation and Review of the Literature.

Front Neurol 2020 24;11:330. Epub 2020 Apr 24.

Division of Pediatric Neurology, Chang Gung Children's Hospital and Chang Gung Memorial Hospital, Taoyuan, Taiwan.

Valproic acid is the most high-risk teratogenic antiepileptic drug, and it may lead to fetal major congenital malformations. However, it is still used in women of childbearing age with epilepsy. The aim of this study was to report our experience of discontinuing or lowering valproic acid by adding levetiracetam, a low-risk teratogenic antiepileptic drug. Read More

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http://dx.doi.org/10.3389/fneur.2020.00330DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7193743PMC

Use of methotrexate in the treatment of ectopic pregnancies: a retrospective single center study.

Facts Views Vis Obgyn 2020 Mar 27;11(4):329-335. Epub 2020 Mar 27.

Obstetrics and Gynecology Department, University of Liege, 4000 Liege, Belgium.

Introduction: The aim of this study was to evaluate the efficacy of methotrexate (MTX) in the treatment of ectopic pregnancies. We identified predictive factors of success or failure and compared our results with previous studies to make recommendations for its use.

Material And Methods: A cohort of 61 patients from a single center was retrospectively analyzed. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7162662PMC

Houtt. alleviates dextran sulfate sodium-induced colitis by protecting tight junctions in mice.

Integr Med Res 2020 Jun 3;9(2):100398. Epub 2020 Mar 3.

Department of Korean Medical Science, School of Korean Medicine, Pusan National University, Yangsan, Republic of Korea.

Background: Houtt. (RJ) is widely distributed in Korea, Japan, and China. The root of RJ has traditionally been used to treat constipation, jaundice, hematemesis, dysfunctional uterine bleeding, and gastrointestinal diseases. Read More

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http://dx.doi.org/10.1016/j.imr.2020.02.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7168767PMC

New Opportunities for Endometrial Health by Modifying Uterine Microbial Composition: Present or Future?

Biomolecules 2020 Apr 11;10(4). Epub 2020 Apr 11.

Department of Biochemistry and Molecular Biology, Faculty of Sciences, University of Granada, 18071 Granada, Spain.

Current knowledge suggests that the uterus harbours its own microbiota, where the microbes could influence the uterine functions in health and disease; however, the core uterine microbial composition and the host-microbial relationships remain to be fully elucidated. Different studies are indicating, based on next-generation sequencing techniques, that microbial dysbiosis could be associated with several gynaecological disorders, such as endometriosis, chronic endometritis, dysfunctional menstrual bleeding, endometrial cancer, and infertility. Treatments using antibiotics and probiotics and/or prebiotics for endometrial microbial dysbiosis are being applied. Read More

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http://dx.doi.org/10.3390/biom10040593DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226034PMC

Localized solitary left renal vein thrombus complicating nutcracker syndrome: a case report and review of the literature.

CEN Case Rep 2020 Aug 3;9(3):252-256. Epub 2020 Apr 3.

Department of Cardiology, Graduate School of Medicine, Gifu University, 1-1 Yanagido, Gifu, 501-1194, Japan.

Nutcracker syndrome (NCS) refers to compression of the left renal vein (LRV) between the abdominal aorta and the superior mesenteric artery (SMA). The clinical presentation of NCS includes hematuria, abdominal and left flank pain, gonadal varices, and varicocele formation. Theoretically, thrombosis can occur in the LRV in patients with NCS. Read More

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http://dx.doi.org/10.1007/s13730-020-00467-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7320084PMC

Protective effect of Clinopodium chinense (Benth.) O. Kuntze against abnormal uterine bleeding in female rats.

J Pharmacol Sci 2020 May 13;143(1):1-8. Epub 2020 Feb 13.

School of Pharmacy, Anhui Province Key Laboratory of Chinese Medicinal Formula, Anhui University of Chinese Medicine, Hefei, China. Electronic address:

Objectives: To investigated the metrorrhagia volume-reduction activity, anti-inflammatory activity and repair-promoting activity of Clinopodium chinense (Benth.) O. Kuntze. Read More

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http://dx.doi.org/10.1016/j.jphs.2020.02.004DOI Listing

Assessment of non-gynecological symptoms before and after removal of the Essure® sterilization device: a 6-month follow-up study.

Minerva Ginecol 2019 Dec;71(6):404-411

Department of Gynecology, Obstetrics and Reproductive Medicine, University Hospital of Brest, Brest, France.

Background: Most of the clinical adverse events associated with the Essure® sterilization device have been attributed to incidents during and immediately after device placement (perforation, infection, expulsion). The aim of this study was to prospectively evaluate the prevalence and severity of non-gynecological clinical symptoms (e.g. Read More

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http://dx.doi.org/10.23736/S0026-4784.19.04391-0DOI Listing
December 2019

[Klippel-Trenaunay-Weber syndrome with vesical and uterine involvement treated by endoscopic and endovascular routes].

Medicina (B Aires) 2020 ;80(1):84-86

Servicio de Ginecología, Hospital Militar Central, Buenos Aires, Argentina.

Klippel-Trenaunay-Weber syndrome (KTWS) is a rare venous malformation that generally affects the lower limbs and, more infrequently, the upper limbs. It is characterized by cutaneous angiomatous formations, varicose veins and hypertrophy of the affected limb. The involvement of the genitourinary tract is extremely infrequent. Read More

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Immediate Postpartum Intrauterine Device in HIV-Infected Women: Experience from a Tertiary Care Center in Côte d'Ivoire.

J Obstet Gynaecol India 2020 Feb 18;70(1):64-68. Epub 2019 Oct 18.

Department of Obstetrics and Gynecology, University Hospital of Treichville, 01 BP V3 Abidjan 01, Abidjan, Côte d'Ivoire.

Background: Immediate postpartum intrauterine device (PPIUD) is a good solution for reducing low contraceptive coverage in developing countries. However, its use in HIV-infected women is poorly documented. The objective of this study was to assess whether the risk of PPIUD complications was higher in HIV-infected women. Read More

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http://dx.doi.org/10.1007/s13224-019-01268-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6982613PMC
February 2020

Elagolix for Heavy Menstrual Bleeding in Women with Uterine Fibroids.

N Engl J Med 2020 01;382(4):328-340

From Thomas Jefferson University (W.D.S.) and the University of Pennsylvania (K.T.B.), Philadelphia; Comprehensive Clinical Trials, West Palm Beach, FL (R.T.A.); University of Illinois at Chicago (A.A.-H.) and Northwestern University (E.C.F.), Chicago, AbbVie, North Chicago (R.L., C.D.O., A.M.S.), and InVia Fertility, Hoffman Estates (E.E.P.) - all in Illinois; Eastern Virginia Medical School, Norfolk (D.F.A.); Cleveland Clinic, Cleveland (L.D.B.); University of Texas Southwestern Medical Center, Dallas (B.R.C.); University of Texas Health Science Center at Houston (S.M.H.) and Advances in Health (A.P.), Houston; Columbia University (J.K.) and SUNY Downstate Health Sciences University (O.M.-D.), New York; private practice, Las Vegas (R.G.M.); Wayne State University, Detroit (E.E.P.); Torre de Auxilio Mutuo, San Juan, Puerto Rico (H.R.-G.); George Washington University, Washington, DC (J.A.S.); Mayo Clinic and Mayo Clinic Alix School of Medicine, Rochester, MN (E.A.S.); and Mercy Health, Cincinnati (N.B.W.).

Background: Uterine fibroids are hormone-responsive neoplasms that are associated with heavy menstrual bleeding. Elagolix, an oral gonadotropin-releasing hormone antagonist resulting in rapid, reversible suppression of ovarian sex hormones, may reduce fibroid-associated bleeding.

Methods: We conducted two identical, double-blind, randomized, placebo-controlled, 6-month phase 3 trials (Elaris Uterine Fibroids 1 and 2 [UF-1 and UF-2]) to evaluate the efficacy and safety of elagolix at a dose of 300 mg twice daily with hormonal "add-back" therapy (to replace reduced levels of endogenous hormones; in this case, estradiol, 1 mg, and norethindrone acetate, 0. Read More

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http://dx.doi.org/10.1056/NEJMoa1904351DOI Listing
January 2020
55.873 Impact Factor

Hysteroscopic endometrial resection vs. hysterectomy for abnormal uterine bleeding: impact on quality of life and sexuality. Evidence from a systematic review of randomized controlled trials.

Curr Opin Obstet Gynecol 2020 Apr;32(2):159-165

Obstetrics and Gynecology Unit, Department of General Surgery and Medical Surgical Specialties, University of Catania, Catania.

Purpose Of Review: The aim of this systematic review is to summarize the current evidence regarding the effectiveness of hysterectomy and hysteroscopic endometrial resection in improving quality of life (QoL), sexual function and psychological wellbeing of women abnormal uterine bleeding.

Recent Findings: We performed a systematic literature search in PubMed/MEDLINE and Embase for original studies written in English (registered in PROSPERO 2019 CRD42019133632), using the terms 'endometrial ablation', 'endometrial destruction', 'endometrial resection', 'hysterectomy', 'menorrhagia', 'dysfunctional uterine bleeding', 'quality of life', 'sexuality' published up to April 2019. Our literature search produced 159 records. Read More

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http://dx.doi.org/10.1097/GCO.0000000000000609DOI Listing
April 2020
2.067 Impact Factor

Intrauterine infection caused by nontyphoidal : a literature review.

J Matern Fetal Neonatal Med 2019 Dec 18:1-5. Epub 2019 Dec 18.

Laboratoire de Microbiologie clinique, Groupe Hospitalier Paris-Saint Joseph, Paris, France.

Although nontyphoidal infections have a prevalence of 0.2-1.8%. Read More

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http://dx.doi.org/10.1080/14767058.2019.1702950DOI Listing
December 2019

Niche-related outcomes after caesarean section and quality of life: a focus group study and review of literature.

Qual Life Res 2020 Apr 16;29(4):1013-1025. Epub 2019 Dec 16.

Department of Obstetrics and Gynaecology, Amsterdam Reproduction and Development Research Institute, Amsterdam UMC, Vrije Universiteit Amsterdam, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands.

Background: A niche in the uterus, present in 60% of women after caesarean section (CS), is associated with several gynaecological symptoms and possibly with subfertility. Studies that focus on quality of life (QoL) in relation to a niche are lacking.

Purpose: To identify niche-related outcomes that influence QoL and to compare patient-reported outcomes with outcomes studied in the literature. Read More

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http://dx.doi.org/10.1007/s11136-019-02376-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7142042PMC

Rare Hereditary Burden associated with a Hypercalcemic Small-Cell Carcinoma of Cervix in a Young Female Patient.

Klin Onkol 2019 ;32(6):456-462

Background: Oncological diseases have, in most cases, a multifactorial etiology, composed of a combination of external and internal environmental factors. Hereditary tumorous syndromes are mostly autosomal dominant diseases with incomplete but very high penetrance.

Observation: The patient, an 18-year-old virgin female, consulted a gynecologist in June 2018 because of metrorrhagia. Read More

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http://dx.doi.org/10.14735/amko2019456DOI Listing

A multicenter, double-blind, randomized trial on the bleeding profile of a drospirenone-only pill 4 mg over nine cycles in comparison with desogestrel 0.075 mg.

Arch Gynecol Obstet 2019 12 14;300(6):1805-1812. Epub 2019 Nov 14.

Exeltis Europe, Adalperostr. 84, 85737, Ismaning, Germany.

Purpose: A typical compliance problem in the use of traditional progestin-only pills is the irregular bleeding pattern and the strict daily intake. Desogestrel 75 mg has a 12-h missed-pill window; however, its poor cycle control limits a more common use.

Methods: A drospirenone (DRSP)-only pill was developed to improve the bleeding profile. Read More

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http://dx.doi.org/10.1007/s00404-019-05340-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7174261PMC
December 2019

[Management of first-trimester vaginal bleeding by general practitioners, with or without orientation to gynecological emergency department].

Presse Med 2019 Nov 11;48(11 Pt 1):1337-1339. Epub 2019 Nov 11.

Centre hospitalier départemental, service de gynécologie obstétrique, 85000 La Roche-sur-Yon, France.

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http://dx.doi.org/10.1016/j.lpm.2019.09.042DOI Listing
November 2019

A prospective clinical cohort study of women at increased risk for endometrial cancer.

Gynecol Oncol 2020 01 9;156(1):169-177. Epub 2019 Nov 9.

Department of Obstetrics and Gynecology, Mayo Clinic, Rochester, MN, USA.

Objective: To evaluate endometrial cancer (EC) risk assessment and early detection strategies in high-risk populations, we designed a large, prospective cohort study of women undergoing endometrial evaluation to assess risk factors and collect novel biospecimens for future testing of emerging EC biomarkers. Here we report on the baseline findings of this study.

Methods: Women aged ≥45 years were enrolled at the Mayo Clinic from February 2013-June 2018. Read More

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http://dx.doi.org/10.1016/j.ygyno.2019.09.014DOI Listing
January 2020

Development and internal validation of a Nomogram for preoperative prediction of surgical treatment effect on cesarean section diverticulum.

BMC Womens Health 2019 11 11;19(1):136. Epub 2019 Nov 11.

Department of Gynecology & Obstetrics, Xinhua Hospital affiliated to Shanghai Jiao Tong University School of Medicine, 1665 Kong Jiang Road, Shanghai, 200092, China.

Background: The aim of this study was to develop and validate an individualized score based on preoperative parameters to predict patient outcomes after vaginal repair of cesarean section diverticulum.

Methods: This is a retrospective cohort study (Canadian Task Force classification II-2). Patients were enrolled between Jun 11, 2012, to May 27, 2016. Read More

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http://dx.doi.org/10.1186/s12905-019-0817-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6849201PMC
November 2019

[Epidemioclinical and ultrasonographic profile of hydatidiform moles in Abidjan].

Pan Afr Med J 2019 29;33:264. Epub 2019 Jul 29.

Service de Radiologie, CHU de Yopougon, Abidjan, Côte d'Ivoire.

Introduction: The purpose of our study was to describe the epidemioclinical and ultrasonographic features of hydatidiform moles (HM) in Abidjan.

Methods: We conducted a cross-sectional study in the Department of Radiology, University Teaching Hospital of Yopougon over a 6-year period (January 2011-December 2016). In this study we describe the epidemioclinical and ultrasonographic profile of patients with HM. Read More

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http://dx.doi.org/10.11604/pamj.2019.33.264.17400DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6814944PMC
November 2019
1 Read

Thyroid Symptomatology across the Spectrum of Hypothyroidism and Impact of Levothyroxine Supplementation in Patients with Severe Primary Hypothyroidism.

Indian J Endocrinol Metab 2019 May-Jun;23(3):373-378

Department of Medicine, Division of Endocrinology, Gandhi Medical College and Hamidia Hospital, Bhopal, India.

Objective: This study aimed to determine the clinical and biochemical profile of patients with severe primary hypothyroidism (SPH) (TSH ≥40 μIU/ml) as compared to milder forms of hypothyroidism and document improvement in hypothyroidism symptoms in SPH.

Methods: Thyroid symptomatology and biochemistry were evaluated in SPH, non-severe overt primary hypothyroidism (NSOPH; TSH <40 μIU/ml), subclinical hypothyroidism (ScH) and healthy controls. A total of 598 consecutive patients of hypothyroidism were screened of which 461 patients' data were analyzed (91 SPH, 130 NSOPH and 240 ScH). Read More

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http://dx.doi.org/10.4103/ijem.IJEM_78_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6683699PMC
October 2019
1 Read

Real-Life Safety and Effectiveness of Lumacaftor-Ivacaftor in Patients with Cystic Fibrosis.

Am J Respir Crit Care Med 2020 01;201(2):188-197

Respiratory Medicine and National Reference Cystic Fibrosis Reference Center, Cochin Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France.

Lumacaftor-ivacaftor is a CFTR (cystic fibrosis transmembrane conductance regulator) modulator combination recently approved for patients with cystic fibrosis (CF) homozygous for the Phe508del mutation. To evaluate the safety and effectiveness of lumacaftor-ivacaftor in adolescents (≥12 yr) and adults (≥18 yr) in a real-life postapproval setting. The study was conducted in the 47 CF reference centers in France. Read More

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http://dx.doi.org/10.1164/rccm.201906-1227OCDOI Listing
January 2020
6 Reads

Relugolix, a novel oral gonadotropin-releasing hormone antagonist, in the treatment of pain symptoms associated with uterine fibroids: a randomized, placebo-controlled, phase 3 study in Japanese women.

Fertil Steril 2019 11 6;112(5):922-929.e2. Epub 2019 Oct 6.

Kindai University, Osaka, Japan.

Objective: To investigate the efficacy and safety of the oral gonadotropin-releasing hormone receptor antagonist, relugolix, in patients experiencing uterine fibroid-associated pain.

Design: Phase 3, multicenter, randomized, double-blind, placebo-controlled study.

Setting: Medical centers. Read More

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http://dx.doi.org/10.1016/j.fertnstert.2019.07.013DOI Listing
November 2019
1 Read

Secondary infertility due to intrauterine fetal bone retention: A case report and review of the literature.

Int J Reprod Biomed (Yazd) 2019 Aug 3;17(8):591-594. Epub 2019 Sep 3.

Tehran University of Medical Science Tehran Iran.

Background: Intrauterine retention of fetal bone fragments is a rare condition that could happen after abortion (especially illegal abortion). It can cause secondary infertility as bone fragments can work as an intrauterine contraceptive device.

Case: A 25-year-old Iranian woman was referred to Shariati Hospital due to infertility. Read More

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http://dx.doi.org/10.18502/ijrm.v17i8.4825DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6745083PMC
August 2019
2 Reads

Hysterectomy and Adenextomy via transvaginal natural orifice transluminal endoscopic surgery (vNOTES): A UK perspective with a case series of 33 patients.

Eur J Obstet Gynecol Reprod Biol 2019 Nov 31;242:29-32. Epub 2019 Aug 31.

Gynaecology Department, Darent Valley Hospital, Darenth Wood Road, Dartford, Kent DA2 8DA, UK.

Objective: To evaluate operative outcomes of hysterectomy +/- adnexectomy by Trans-vaginal Natural Orifice Endoscopic Surgery (vNOTES) in a case series of 33 patients.

Study Design: It was a prospective case series study carried out in Darent Valley and Benenden Hospital, to our knowledge, the first units in the United Kingdom to have undertaken VNOTE Hysterectomy. We collected data on a private shared drive noting patient demographics, indications for surgery, operation outcomes and patient follow-up details. Read More

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http://dx.doi.org/10.1016/j.ejogrb.2019.08.023DOI Listing
November 2019
6 Reads

Prevalence of Infertility Among Patients With Isthmocele and Fertility Outcome After Isthmocele Surgical Treatment: A Retrospective Study.

Ochsner J 2019 ;19(3):204-209

Instituto Valenciano de Infertilidad, IVI-RMA Global, Madrid, Spain.

An isthmocele is a diverticulum on the anterior wall of the uterine isthmus at the site of a cesarean delivery scar. We evaluated the prevalence of infertility among patients with isthmocele, the resolution of symptoms, and infertility outcomes after hysteroscopic isthmoplasty. We conducted a retrospective study of 35 consecutive patients with symptomatic isthmocele between 2010 and 2015 at Hospital Piero Palagi in Florence, Italy. Read More

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http://dx.doi.org/10.31486/toj.18.0048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6735591PMC
January 2019
2 Reads

The accuracy of endometrial sampling for the diagnosis of patterns of endometrial pathology in women presenting with abnormal uterine bleeding. More conservative therapeutic approaches.

Saudi Med J 2019 Aug;40(8):815-819

Pathology Department, Imam Abdulrahman Bin Faisal University, Dammam, Kingdom of Saudi Arabia. E-mail.

Objectives: Abnormal uterine bleeding (AUB) is a leading cause of hysterectomies, the cause of which is usually diagnosed with preoperative endometrial sampling. We planned this study to assess the accuracy of diagnosing the histologic patterns of endometrium in the preoperative sample in reference to the final histologic diagnosis in hysterectomy.

Methods: We retrospectively reviewed medical charts between January 2011 and December 2015 at a tertiary hospital in Saudi Arabia and identified 43 cases of AUB with complete documentation. Read More

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http://dx.doi.org/10.15537/smj.2019.8.24449DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6718861PMC
August 2019
3 Reads

Clinico-pathological features of gynecological myopericytoma: a challenging diagnosis in an exceptional location.

Virchows Arch 2019 Dec 13;475(6):763-770. Epub 2019 Aug 13.

Obstetrics and Gynaecology Unit, Department of Surgical Sciences, University of Turin, Via Ventimiglia 3, Turin, 10126, Italy.

Myopericytomas (MPC) are rare mesenchymal tumors, originating from the perivascular myoid cells. They predominantly occur in the skin and superficial soft tissues of the extremities, while visceral involvement is rare. Histological features and clinical course are usually benign. Read More

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http://dx.doi.org/10.1007/s00428-019-02645-2DOI Listing
December 2019
2 Reads

Metrorrhagia iuvenilis and Premenstrual Syndrome as frequent problems of adolescent gynecology with aspects of diet therapy.

Ginekol Pol 2019 ;90(7):423-429

Division of Developmental Gynecology and Sexology, Department of Perinatology and Gynecology, Poznan University of Medical Sciences, Poland.

Painful menstruation, premenstrual syndrome and metrorrhagia iuvenilis are one of the most common problems related to the sexual cycle in adolescent girls. Metrorrhagia iuvenilis is acyclic bleeding that occurs in adolescents and lasts from over 10 days even up to 3 months. These bleeds are very abundant and have a tendency to relapse. Read More

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https://journals.viamedica.pl/ginekologia_polska/article/vie
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http://dx.doi.org/10.5603/GP.2019.0072DOI Listing
March 2020
6 Reads

Obstetrical and postpartum complications in women with hereditary fibrinogen disorders: A systematic literature review.

Haemophilia 2019 Sep 31;25(5):747-754. Epub 2019 Jul 31.

Division of angiology and hemostasis, University Hospitals of Geneva, Geneva, Switzerland.

Introduction: Hereditary fibrinogen disorders (HFD) are rare quantitative or qualitative fibrinogen anomalies, including afibrinogenaemia (A), hypofibrinogenaemia (H), dysfibrinogenaemia (D) and hypodysfibrinogenaemia (HD). As fibrinogen plays an essential role in pregnancy, we addressed the issue of obstetrical and postpartum complications in women with HFD.

Methods: A systematic literature review, restricted to English manuscripts, was conducted according to the PRISMA guidelines. Read More

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http://dx.doi.org/10.1111/hae.13825DOI Listing
September 2019
5 Reads

Multicenter, phase III trials on the contraceptive efficacy, tolerability and safety of a new drospirenone-only pill.

Acta Obstet Gynecol Scand 2019 12 6;98(12):1549-1557. Epub 2019 Aug 6.

Exeltis Europe, Ismaning, Germany.

Introduction: Approximately 100 million women currently use combined oral contraceptives. Combined oral contraceptives use is associated with increased risk of venous thromboembolic events and cardiovascular disease. Progestin-only pills do not increase the risk of venous thromboembolic events, stroke and myocardial infarction but are associated with a poor cycle control. Read More

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http://dx.doi.org/10.1111/aogs.13688DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7186823PMC
December 2019
8 Reads

Endometrial ablation; less is more? Historical cohort study comparing long-term outcomes from two time periods and two treatment modalities for 854 women.

PLoS One 2019 10;14(7):e0219294. Epub 2019 Jul 10.

Department of Obstetrics and Gynecology, Haukeland University Hospital, Bergen, Norway.

Background: Abnormal uterine bleeding needs surgical treatment if medical therapy fails. After introduction of non-hysteroscopic endometrial ablation as alternative to hysteroscopic endometrial resection, we aimed to compare short and long-term outcomes for women treated with these two minimally-invasive procedures. A secondary goal was comparing the present cohort to a previous cohort of women treated with hysteroscopic resection only. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0219294PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6619760PMC
February 2020
4 Reads

Expanding the phenotypic spectrum of MBOAT7-related intellectual disability.

Am J Med Genet B Neuropsychiatr Genet 2019 10 8;180(7):483-487. Epub 2019 Jul 8.

Department of Pediatrics and Communicable Diseases, Division of Pediatric Genetics, Metabolism and Genomic Medicine, University of Michigan, Ann Arbor, Michigan.

MBOAT7 gene pathogenic variants are a newly discovered and rare cause for intellectual disability, autism spectrum disorder (ASD), seizures, truncal hypotonia, appendicular hypertonia, and below average head sizes (ranging from -1 to -3 standard deviations). There have been only 16 individuals previously reported who have MBOAT7-related intellectual disability, all of whom were younger than 10 years old and from consanguineous relationships. Thus, there is a lack of phenotypic information for adolescent and adult individuals with this disorder. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/ajmg.b.32749
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http://dx.doi.org/10.1002/ajmg.b.32749DOI Listing
October 2019
4 Reads

Bleeding patterns with the 19.5 mg LNG-IUS, with special focus on the first year of use: implications for counselling.

Eur J Contracept Reprod Health Care 2019 Aug 21;24(4):251-259. Epub 2019 Jun 21.

c Bayer Oy , Espoo , Finland.

The aim of the study was to provide an additional, detailed description of early bleeding patterns with the 19.5 mg levonorgestrel-releasing intrauterine system (LNG-IUS). We conducted a pooled analysis of the bleeding diaries of participants in a previously reported phase II randomised controlled study ( = 741) and a phase III study ( = 2904), with 2-year extension phase ( = 707), of the 19. Read More

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http://dx.doi.org/10.1080/13625187.2019.1630817DOI Listing
August 2019
11 Reads

Step by Step Total Laparoscopic Hysterectomy with Uterine Arteries Ligation at the Origin.

J Minim Invasive Gynecol 2020 01 12;27(1):22-23. Epub 2019 Jun 12.

Fondazione Policlinico Universitario A. Gemelli IRCCS (Drs. Gueli Alletti, Restaino, Scambi, and Fanfani), UOC di Ginecologia Oncologica, Dipartimento per la Tutela della Salute della Donna e della Vita Nascente, Roma, Italia.

Study Objective: To reveal principles and the feasibility of a total laparoscopic hysterectomy (TLH) with uterine artery ligation at the origin.

Design: Step-by-step demonstration and explanation of technique using videos from patients.

Setting: Gynecologic oncology unit at a university hospital. Read More

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http://dx.doi.org/10.1016/j.jmig.2019.06.001DOI Listing
January 2020
14 Reads

Hormonal cytology.

Cesk Patol 2019 ;55(2):96-106

The spectrum of hormonal disorders of children and adolescents is broad. It reflects some current features of the advancing lifestyle and health of the population: thelarche praecox and accelerated development in young girls - early menarche, dysfunctional juvenile metrorrhagia, eating disorders - anorexia-bulimia, obesity increase, extreme sports load, autoimmune disorders, central and peripheral endocrine disorders, and others. Many of these conditions can be favorably influenced by professional lifestyle adjustments and fine hormonal medication with simultaneous monitoring of the adjusting cytogram. Read More

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June 2019
4 Reads

Quality of life in patients who undergo conventional or robotic-assisted total laparoscopic hysterectomy: Protocol for a systematic review of randomized controlled trials.

Medicine (Baltimore) 2019 Jun;98(23):e15974

Department of Nursing, São Paulo State University (UNESP), Medical School, Botucatu.

Background: Hysterectomy for benign gynecologic diseases, especially dysfunctional uterine bleeding, is one of the most common gynecologic interventions. The uterus can be removed using abdominal, vaginal, laparoscopic, or robotic-assisted laparoscopic hysterectomy. In a robotic-assisted procedure, the surgeon directs the robot while seated at a console in the operating room. Read More

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http://dx.doi.org/10.1097/MD.0000000000015974DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6571212PMC
June 2019
9 Reads

Detection of complicated ectopic pregnancies in the hospital discharge database: A validation study.

PLoS One 2019 5;14(6):e0217674. Epub 2019 Jun 5.

EA 7285, Research Unit "Risk and Safety in Clinical Medicine for Women and Perinatal Health", Versailles-Saint-Quentin University (UVSQ), Montigny-le-Bretonneux, France.

Objective: Complicated ectopic pregnancies with severe bleeding (CEPSB) are life-threatening situations and should be considered maternal near-miss cases. Previous studies have found an association between severe maternal morbidity secondary to CEPSB and substandard care. Almost all women with CEPSB are hospitalized, generating administrative and medical records. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0217674PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6550422PMC
February 2020
5 Reads

Isthmocele: an overview of diagnosis and treatment.

Rev Assoc Med Bras (1992) 2019 Jun 3;65(5):714-721. Epub 2019 Jun 3.

Department of Gynecology and Obstetrics at the Federal University of Health Sciences of Porto Alegre (UFCSPA), Porto Alegre, RS, Brasil.

An isthmocele, a cesarean scar defect or uterine niche, is any indentation representing myometrial discontinuity or a triangular anechoic defect in the anterior uterine wall, with the base communicating to the uterine cavity, at the site of a previous cesarean section scar. It can be classified as a small or large defect, depending on the wall thickness of the myometrial deficiency. Although usually asymptomatic, its primary symptom is abnormal or postmenstrual bleeding, and chronic pelvic pain may also occur. Read More

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http://dx.doi.org/10.1590/1806-9282.65.5.714DOI Listing
June 2019
8 Reads

Effectiveness of dienogest in improving quality of life in Asian women with endometriosis (ENVISIOeN): interim results from a prospective cohort study under real-life clinical practice.

BMC Womens Health 2019 05 16;19(1):68. Epub 2019 May 16.

Division of Gynecologic Endocrinology and Infertility, Department of Obstetrics and Gynecology, Severance Hospital,Yonsei University, 50-1 Yonsei-ro, Seodaemun-gu, 120-752, Seoul, Republic of Korea.

Background: Dienogest has been shown to substantially improve endometriosis-associated symptoms such as debilitating chronic pelvic pain, and in turn, health-related quality of life (HRQoL). To date, there is no data on patient-reported outcomes reflecting the real-world practice in Asia where endometriosis is a relevant health, social and economic burden. This non-interventional, multi-center, prospective study aims to investigate the influence of dienogest on HRQoL. Read More

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https://bmcwomenshealth.biomedcentral.com/articles/10.1186/s
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http://dx.doi.org/10.1186/s12905-019-0758-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6524261PMC
May 2019
18 Reads

Uterine cervical ulceration caused by group C streptococcal infection during pregnancy: A case report.

J Obstet Gynaecol Res 2019 Aug 9;45(8):1593-1596. Epub 2019 May 9.

Department of Obstetrics and Gynecology, Japan Community Healthcare Organization (JCHO) Osaka Hospital, Osaka, Japan.

Causes of cervical ulceration include infection, collagen disease, malignant tumors and external stimuli. Cervical ulceration during pregnancy is rare. We present a case of cervical ulceration caused by group C streptococcal infection during pregnancy. Read More

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http://dx.doi.org/10.1111/jog.14000DOI Listing
August 2019
5 Reads
0.931 Impact Factor

Channel-like 360° Isthmocele Treatment with a 16F Mini-Resectoscope: A Step-by-step Technique.

J Minim Invasive Gynecol 2019 Nov - Dec;26(7):1229-1230. Epub 2019 May 3.

Gynecology and Human Reproduction Physiopathology Unit (Drs. Morra, Paradisi, and Seracchioli), Sant'Orsola Hospital, University of Bologna, Bologna, Italy.

Study Objective: To show the technique of hysteroscopic channel-like 360° repair of a cesarean scar defect performed with a Gubbini 16F miniresectoscope (GUBBINI system; Tontarra Medizintechnik, Tuttlingen, Germany).

Design: A step-by-step demonstration of the surgical technique using slides, pictures, and a video (an instructive video [Video 1]).

Setting: A university hospital (Bologna University Hospital, Sant'Orsola-Malpighi Polyclinic, Bologna, Italy). Read More

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http://dx.doi.org/10.1016/j.jmig.2019.04.024DOI Listing
May 2020
13 Reads

Perioperative Interventions to Minimize Blood Loss at the Time of Hysterectomy for Uterine Leiomyomas: A Systematic Review and Meta-analysis.

J Minim Invasive Gynecol 2019 Nov - Dec;26(7):1234-1252.e1. Epub 2019 Apr 27.

Women's Health Institute (Drs. Gingold, Chichura, and Kho). Electronic address:

Study Objective: Hysterectomy for uterine leiomyoma(s) is associated with significant morbidity including blood loss. A systematic review and meta-analysis was conducted to identify nonhormonal interventions, perioperative surgical interventions, and devices to minimize blood loss at the time of hysterectomy for leiomyoma.

Data Sources: Librarian-led search of Embase, MEDLINE, Web of Science, Scopus, Cumulative Index to Nursing and Allied Health Literature, and Cochrane databases from 1946 to 2018 with hand-guided updates. Read More

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http://dx.doi.org/10.1016/j.jmig.2019.04.021DOI Listing
May 2020
18 Reads

Outcomes after Hysteroscopic Treatment of Symptomatic Isthmoceles in Patients with Abnormal Uterine Bleeding and Pelvic Pain: A Prospective Case Series.

Int J Fertil Steril 2019 Jul 27;13(2):108-112. Epub 2019 Apr 27.

Department of Obstetrics and Gynecology, University Hospital HM Montepríncipe, Madrid, Spain.

Background: Isthmoceles are described as complications associated with caesarean section (CS). Only symptomatic isthmoceles should be treated. The main symptoms are abnormal uterine bleeding (AUB) in the absence of any other causes, pelvic pain and secondary infertility. Read More

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http://ijfs.ir/journal/article/abstract/5704
Publisher Site
http://dx.doi.org/10.22074/ijfs.2019.5704DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6500081PMC
July 2019
15 Reads