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    1 OF 76

    Successful medical treatment of a hepatic pregnancy: a case report.
    J Med Case Rep 2017 Mar 15;11(1):70. Epub 2017 Mar 15.
    Gynaecology and Obstetrics Unit, Douala Gynaeco-Obstetric and Paediatric Hospital, Douala, Cameroon.
    Background: Hepatic pregnancy is a rare form of abdominal pregnancy, often documented only as case reports.

    Case Presentation: We report here the case of a 24-year-old African woman, gravida 4 para 3, presenting with right upper quadrant pains and metrorrhagia after amenorrhea of 8 weeks 5 days. Elements in favor of the diagnosis of hepatic pregnancy were her clinical presentation, the kinetics of β-human chorionic gonadotropin titers, and the presence of a sub-hepatic mass on ultrasound. Read More

    Intracavitary ethanol ablation for the management of uterine hemorrhage refractory to uterine artery embolization.
    Clin Imaging 2017 Jan 30;43:83-87. Epub 2017 Jan 30.
    Department of Radiology, Louisiana State University Health Shreveport, 1501 Kings Highway, Shreveport, LA 71130, United States. Electronic address:
    A 57-year-old postmenopausal woman with end-stage liver disease secondary to alcoholic cirrhosis, esophageal varices, severe alcoholic cardiomyopathy, and metrorrhagia causing persistent anemia despite multiple transfusions presented with heavy vaginal bleeding. The patient underwent two uterine artery embolizations with proximal coils instead of directed particles due to difficult anatomy but the bleeding continued despite these interventions. Since she was a poor surgical candidate for hysterectomy, the decision was made to attempt achievement of hemostasis via ethanol injection into the uterine cavity. Read More

    Ovarian Leydig cells (OLC): A histomorphological and immunohistochemical study.
    Histol Histopathol 2017 Jan 27:11876. Epub 2017 Jan 27.
    Department of Basic Medical Sciences, Faculty of Health Sciences, Medicine Section, University of La Laguna, Tenerife, Spain.
    Testicular Leydig cells (LC) regulate the proper development of male individuals, both during fetal life (fetal LC) and puberty (adult LC). In the ovaries of adult women, there are cells that are very similar to Leydig cells, the ovarian hilus cells (OHC), which also produce testosterone. The origin of these cells, in both sexes, remains unknown and is still a matter of debate. Read More

    Heavy Menstrual Bleeding in Adolescents.
    J Pediatr Adolesc Gynecol 2017 Jan 17. Epub 2017 Jan 17.
    Baylor College of Medicine, Houston, Texas. Electronic address:
    Heavy menstrual bleeding (HMB) is a very common gynecological condition in female adolescents and a frequent presenting complaint of those with bleeding disorders. Recommendations have been established to screen for bleeding disorders in this age group where appropriate. The purpose of this document is to impart clinical recommendations regarding HMB in adolescents. Read More

    Sphincter-saving resection by cluneal arched skin incision for a gastrointestinal stromal tumor (GIST) of the lower rectum: a case report.
    Surg Case Rep 2017 Dec 5;3(1). Epub 2017 Jan 5.
    Department of Surgery, Chugoku Rosai Hospital, 1-5-1, Tagaya, Hiro, Kure City, Hiroshima, 737-0193, Japan.
    Background: Planning the surgical strategy for a gastrointestinal stromal tumor (GIST) at the posterior wall of the lower rectum is difficult, as the procedures for the lower rectum are hampered by poor visualization and may cause anal dysfunction or discomfort. We report a novel procedure to resect a submucosal tumor of the rectum.

    Case Presentation: A 75-year-old woman presented with metrorrhagia. Read More

    Hysteroscopy in Abnormal Uterine Bleeding vs Ultrasonography and Histopathology Report in Perimenopausal and Postmenopausal Women.
    JNMA J Nepal Med Assoc 2016 Jul-Sep;55(203):26-28
    Department of General Practice and Emergency Medicine, TUTH, MMC, Institute of Medicine, TU, Nepal.
    Introduction: Abnormal uterine bleeding is one of the most common morbidity landing women to attend medical attention in gynecology outpatient department. This study aims to evaluate the hysteroscopy finding in diagnosis of AUB and its correlation with ultrasonography finding and histopathological reports.

    Methods: This was a prospective comparative study in which ultrasonography was performed in fifty patients with abnormal uterine bleeding attending OPD then hysteroscopy was performed. Read More

    Practical aspects of the two FIGO systems for management of abnormal uterine bleeding in the reproductive years.
    Best Pract Res Clin Obstet Gynaecol 2017 Apr 1;40:3-22. Epub 2016 Oct 1.
    Departments of Obstetrics and Gynecology, David Geffen School of Medicine, University of California, Los Angeles and Kaiser Permanente, Los Angeles Medical Center, USA. Electronic address:
    The FIGO systems defining the nomenclature and symptoms of abnormal uterine bleeding (AUB) in the reproductive years (System 1) and the PALM-COEIN classification of causes of AUB (System 2) are designed to facilitate research, education, and the provision of optimum clinical care for affected women. Development of these systems has been the result of a collaborative effort of experts in bench and translational and clinical research from six continents aided by a spectrum of representatives from relevant medical societies, journals, and regulatory bodies. Integral to this development has been a decision to cease the use of poorly defined and inconsistently used terms such as menorrhagia, metrorrhagia, and dysfunctional uterine bleeding, to name a few, and replace them with a set of terms and definitions that are relatively easily understood and translated into the spectrum of languages used by medical providers and patients globally. Read More

    [The contribution of ultrasonography in the exploration of postmenopausal metrorrhagias].
    Pan Afr Med J 2016 30;24:175. Epub 2016 Jun 30.
    Service de Gynécologie Obstétrique «A», Centre de Maternité et de Néonatologie de Tunis, Tunisie.
    Post-menopausal metrorrhagias represent a frequent reason for consultation in gynecology. Our study aims to evaluate the contribution of pelvic ultrasonography in the exploration of endocavitary lesions in people experiencing this symptom and to compare the results found with those of hysteroscopy and histology. This was an analytic retrospective study of 33 cases referred for evaluation of postmenopausal metrorrhagias at the department of gynecology and obstetrics «A» in the Center of Maternity and Neonatology of Tunis in 2012. Read More

    Sonographic Evaluation for Endometrial Polyps: The Interrupted Mucosa Sign.
    J Ultrasound Med 2016 Nov 14;35(11):2381-2387. Epub 2016 Sep 14.
    Department of Radiology, University of Michigan, Ann Arbor, Michigan USA.
    Objectives: To evaluate the interrupted mucosa sign for identification of endometrial polyps, using pathologic confirmation as the reference standard, compared to other accepted sonographic findings.

    Methods: We reviewed 195 patients referred for pelvic sonographic evaluations for suspected endometrial polyps in this retrospective Institutional Review Board-approved study. Of these, 82 had tissue sampling of the endometrium and constituted the final study group. Read More

    Dysfunctional uterine bleeding as an early sign of polycystic ovary syndrome during adolescence: an update.
    Minerva Ginecol 2017 Feb 27;69(1):68-74. Epub 2016 Oct 27.
    Division of Pediatric-Adolescent Gynecology and Reconstructive Surgery, Second Department of Obstetrics and Gynecology, National and Kapodistrian University of Athens, Medical School, Aretaieion Hospital, Athens, Greece.
    Abnormal uterine bleeding (AUB) is a frequent reason for concern between adolescents. The most common cause of AUB in these girls, when other pathologies have been excluded, is dysfunctional uterine bleeding (DUB). The aim of this review is to assess the role of DUB as an early symptom of polycystic ovarian syndrome (PCOS) diagnosis later in life. Read More

    Transcatheter arterial embolization with ethylene vinyl alcohol copolymer (Onyx) for the treatment of hemorrhage due to uterine arteriovenous malformations.
    Diagn Interv Imaging 2016 Oct 21. Epub 2016 Oct 21.
    Department of radiology, hôpital de la Timone, 264, rue Saint-Pierre, 13385 Marseille cedex 05, France.
    Purpose: The purpose of this study was to evaluate the effectiveness of ethylene vinyl alcohol copolymer (Onyx) as a single embolic agent for percutaneous arterial treatment of hemorrhage due to uterine arteriovenous malformations (AVMs).

    Materials And Methods: Twelve women (mean age, 33 years) with metrorrhagia due to uterine AVMs who were treated by percutaneous arterial embolization using Onyx as a single embolic agent were retrospectively included. The diagnosis of uterine AVM was suggested by pelvic ultrasound and/or magnetic resonance imaging findings and further confirmed by angiography. Read More

    Von Willebrand disease in sub-Saharan Africa: a first severe case reported in Cameroon.
    Blood Coagul Fibrinolysis 2016 Oct;27(7):835-837
    aFaculty of Medicine and Biomedical Sciences, University of Yaoundé IbHematology and Blood Transfusion Unit, University Teaching Hospital of Yaoundé, Yaoundé, CamerooncDivision of Angiology and Hemostasis, Geneva University Hospitals, Switzerland.
    In Cameroon, the Yaoundé Hemophilia Treatment Center (HTC) has so far recorded 121 cases of hemophilia and only 10 cases of von Willebrand disease (VWD). We report the case of a 16-year-old girl, living in the north of Cameroon. She presented with severe meno-metrorrhagia, which had increased drastically within the past 3 months, associated more recently by gum bleeding and epistaxis. Read More

    Indications and Route of Hysterectomy for Benign Diseases. Guideline of the DGGG, OEGGG and SGGG (S3 Level, AWMF Registry No. 015/070, April 2015)
    Geburtshilfe Frauenheilkd 2016 04;76(4):350-364
    Universitäts-Frauenklinik Graz.
    Background: Official guideline "indications and methods of hysterectomy" to assign indications for the different methods published and coordinated by the German Society of Gynecology and Obstetrics (DGGG), the Austrian Society of Gynecology and Obstetrics (OEGGG) and the Swiss Society of Gynecology and Obstetrics (SGGG). Besides vaginal and abdominal hysterectomy, three additional techniques have been implemented due to the introduction of laparoscopy. Organ-sparing alternatives were also integrated. Read More

    [A clinical analysis of gynecological diseases in 147 children].
    Zhongguo Dang Dai Er Ke Za Zhi 2016 Sep;18(9):846-850
    Department of Gynecology, Xiangya Hospital, Central South University, Changsha 410008, China.
    Objective: To study the clinical features of gynecological diseases in hospitalized children.

    Methods: A retrospective analysis was performed for the clinical data of 147 children with gynecological diseases who were hospitalized and treated in the department of gynecology.

    Results: Among the 147 children, ovarian tumors were most common (53 cases, 36. Read More

    Rapid screening and identification of the differences between metabolites of Cistanche deserticola and C. tubulosa water extract in rats by UPLC-Q-TOF-MS combined pattern recognition analysis.
    J Pharm Biomed Anal 2016 Nov 14;131:364-372. Epub 2016 Sep 14.
    School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, China. Electronic address:
    Cistanches Herba is a famous traditional Chinese medicine that has been in use for treating kidney deficiency, impotence, female infertility, morbid leucorrhea, profuse metrorrhagia, and senile constipation. With the exception of studies available for a few single active ingredients such as echinacoside, acteoside, and poliumoside, comprehensive and systematic studies on in vivo metabolism of Cistanches Herba are lacking despite its widespread clinical application. There is no comparative study yet on the metabolites resulting from the traditional usage of Cistanche deserticola and C. Read More

    Evaluation of the Hemostatic Disorders in Adolescent Girls with Menorrhagia: Experiences from a Tertiary Referral Hospital.
    Indian J Hematol Blood Transfus 2016 Sep 22;32(3):356-61. Epub 2015 Aug 22.
    Department of Pediatric Hematology, Yuzuncu Yil University, 65100 Van, Turkey.
    Bleeding disorders are a common cause of menorrhagia in the adolescent age group. We aimed to evaluate the incidence of hemostatic disorders, using clinical and laboratory findings of bleeding disorders in adolescent girls with menorrhagia. A retrospective chart review used to evaluate adolescent girls with menorrhagia who were referred to Yuzuncu Yil University Pediatric Hematology clinic between January 2010 and December 2014. Read More

    Adolescent Gynecologic Emergencies.
    Adolesc Med State Art Rev 2015 Dec;26(3):473-83
    Adolescent females frequently present to the ED with complaints that may be caused by a gynecologic emergency. Differentiating and excluding some of the common and most serious gynecologic emergencies reviewed in this article are critical. Timely and effective treatment of these conditions, once diagnosed, can result in better health outcomes. Read More

    [Radiotherapy for endometrial cancer: experience of the national institute of oncology with 52 cases].
    Pan Afr Med J 2016 30;23:144. Epub 2016 Mar 30.
    Service de Radiothérapie, Institut National d'Oncologie, Université Mohammed V Souissi, Rabat, Maroc.
    Endometrial cancer is the most common gynecological cancer in the Western world. It affects mainly postmenopausal women. The aim of our study is to report the experience of the radiotherapy department of the National Oncology Institute (INO) in the treatment of endometrial cancer. Read More

    Endometrial study in patients with postmenopausal metrorrhagia.
    Arch Med Sci 2016 Jun 18;12(3):597-602. Epub 2016 May 18.
    Department of Medical Sciences, School of Medicine, University Autonóma, Madrid, Spain.
    Introduction: The aim of the study was to devise a strategy to diagnose malign endometrial pathologies (adenocarcinoma or atypical hyperplasia) that minimizes the number of invasive tests done (hysteroscopy, aspiration biopsy or curettage) with no loss of its detection efficiency.

    Material And Methods: We retrospectively studied the clinical histories of 779 postmenopausal women at the University Hospital Complex of Albacete, for whom an endometrial study had been done (hysteroscopy, aspiration biopsy or curettage) with a 1-year follow-up between 1 March 2006 and 31 March 2008.

    Results: There were 77 cases of a malignant pathology (66 adenocarcinomas and 11 hyperplasias with atypia); 96. Read More

    Conservative Resectoscopic Surgery, Successful Delivery, and 60 Months of Follow-Up in a Patient with Endometrial Stromal Tumor with Sex-Cord-Like Differentiation.
    Case Rep Obstet Gynecol 2016 26;2016:5736865. Epub 2016 Apr 26.
    Department of Women, Child and General and Specialized Surgery, Second University of Naples, Largo Madonna delle Grazie 1, 80138 Napoli, Italy.
    Uterine tumors with sex-cord-like differentiation are extremely rare types of uterine stromal neoplasm. These tumors were classified into two groups with considerable practical relevance because clinical behaviour of uterine tumor resembling ovarian sex cord tumor (UTROSCT) differs widely from its closely related endometrial stromal tumors with sex-cord-like elements (ESTSCLE). Treatment and prognosis of these tumors are unresolved issues because of the exiguous number of reported cases. Read More

    A Randomised Controlled Trial Comparing the Efficacy and Side-Effects of Intravaginal Ring (Nuvaring(®)) With Combined Oral Hormonal Preparation in Dysfunctional Uterine Bleeding.
    J Clin Diagn Res 2016 Mar 1;10(3):QC21-4. Epub 2016 Mar 1.
    Professor, Department of Obstetrics and Gynecology, University College of Medical Sciences and Guru Teg Bahadur Hospital , Delhi, India .
    Introduction: Combined Oral Contraceptive (COC) pills are being used in patients of abnormal uterine bleeding, especially adolescents and reproductive age women considering their need for contraception. It decreases the blood loss due to haemostatic effect of estrogen and also regularizes the cycle. Intravaginal route has been found to be effective and acceptable; Gastrointestinal absorption and hepatic first-pass metabolism is avoided and steady, uniform blood concentration is achieved. Read More

    Rev Med Chir Soc Med Nat Iasi 2016 Jan-Mar;120(1):145-51
    Uterine leiomyomas are benign tumors arising from uterine smooth muscle. Although their pathogenesis remains unclear, they are the most common tumor of the female reproductive tract, occurring in as many as half of women older than 35 years. Uterine leiomyomas represent the most common benign tumors of the female reproductive tract. Read More

    Herba Cistanche (Rou Cong-Rong): One of the Best Pharmaceutical Gifts of Traditional Chinese Medicine.
    Front Pharmacol 2016 1;7:41. Epub 2016 Mar 1.
    Translational Medicine Research Center, School of Pharmaceutical Sciences, Xiamen UniversityXiamen, China; Key Laboratory for Cancer T-Cell Theranostics and Clinical TranslationXiamen, China; INNOVA Clinics and TRANSLA Health GroupXiamen, China.
    Cistanche species, known as Rou Cong-Rong in Chinese, are an endangered wild species and are mainly distributed in the arid lands and warm deserts of northwestern China. Within Traditional Chinese Medicine (TCM), Herba Cistanche is applied as a tonic and/or in a formula for chronic renal disease, impotence, female infertility, morbid leucorrhea, profuse metrorrhagia, and senile constipation. The chemical constituents of Herba Cistanche mainly consist of volatile oils, non-volatile phenylethanoid glycosides (PhGs), iridoids, lignans, alditols, oligosaccharides, and polysaccharides. Read More

    Comparison of classic terminology with the FIGO PALM-COEIN system for classification of the underlying causes of abnormal uterine bleeding.
    Int J Gynaecol Obstet 2016 Jun 16;133(3):325-8. Epub 2016 Feb 16.
    Department of Gynecology and Obstetrics, Izmir Tepecik Teaching and Research Hospital, Izmir, Turkey.
    Objective: To compare classic terminology and the PALM-COEIN (polyp, adenomyosis, leiomyoma, malignancy and hyperplasia, coagulopathy, ovulatory disorders, endometrium, iatrogenic, and not classified) classification system among women who underwent surgery for abnormal uterine bleeding (AUB), and to subclassify the components of the PALM group for future studies.

    Methods: In a retrospective study, data were obtained for nonpregnant women aged 18-55years who underwent hysterectomy, myomectomy, or polypectomy for AUB at a center in Turkey in 2014. The patients were retrospectively classified according to the PALM-COEIN system, and the two terminologies were compared. Read More

    Mood and anxiety disorders in patients with abnormal uterine bleeding.
    Eur J Obstet Gynecol Reprod Biol 2016 Apr 28;199:192-7. Epub 2016 Feb 28.
    Department of Radiology, Konya Training and Research Hospital, Konya, Turkey. Electronic address:
    Objective: We aimed to investigate the prevalence of mood and anxiety disorders in patients with abnormal uterine bleeding (AUB) and the relationship between mood and anxiety disorders and AUB.

    Method: 96 consecutive patients with not yet classified AUB based on the PALM-COEIN classification and 94 volunteers were included in the study. Mood and anxiety disorders were ascertained by means of the Structured Clinical Interview for the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition/Clinical Version. Read More

    The use of micronised progesterone for menopausal hormone therapy, a clinical practice audit.
    Aust N Z J Obstet Gynaecol 2016 Jun 29;56(3):323-5. Epub 2016 Feb 29.
    Women's Health Research Program, School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.
    A clinical practice audit was undertaken to share an Australian experience of the use of micronised progesterone (mP) 100 mg daily as part of menopausal hormone therapy (MHT). Ninety-nine women attending a single practitioner were offered the option of mP as a component of MHT, under the Australian Authorised Prescriber Scheme, over 2.5 years. Read More

    Consecutive lynestrenol and cross-sex hormone treatment in biological female adolescents with gender dysphoria: a retrospective analysis.
    Biol Sex Differ 2016 16;7:14. Epub 2016 Feb 16.
    Department of Pediatrics and Genetics, Ghent University, Ghent, Belgium ; Division of Pediatric Endocrinology, Department of Pediatrics, Ghent University Hospital, Ghent, Belgium ; Princess Elisabeth Children's Hospital, Building 3K12D, De Pintelaan 185, 9000 Ghent, Belgium.
    Background: Prior to the start of cross-sex hormone therapy (CSH), androgenic progestins are often used to induce amenorrhea in female to male (FtM) pubertal adolescents with gender dysphoria (GD). The aim of this single-center study is to report changes in anthropometry, side effects, safety parameters, and hormone levels in a relatively large cohort of FtM adolescents with a diagnosis of GD at Tanner stage B4 or further, who were treated with lynestrenol (Orgametril®) monotherapy and in combination with testosterone esters (Sustanon®).

    Methods: A retrospective analysis of clinical and biochemical data obtained during at least 6 months of hormonal treatment in FtM adolescents followed at our adolescent gender clinic since 2010 (n = 45) was conducted. Read More

    Clinco-Pathological Patterns in Women with Dysfunctional Uterine Bleeding.
    Iran J Pathol 2016 ;11(1):20-6
    Dept. of Pathology,Hamdard Institute of Medical Sciences and Research, Jamia Hamdard, Hamdard Nagar, New Delhi, India.
    Background: The term dysfunctional uterine bleeding (DUB) refers to any abnormal bleeding from the uterus, unassociated with tumour, inflammation and pregnancy. The histological diagnosis of DUB is very essential for adequate management especially in perimenopausal and postmenopausal females. The present study was undertaken with the aim of evaluating DUB in various age groups, carry out histopathological study of the endometrium and analyze its clinic-pathological patterns. Read More

    Abnormal uterine bleeding.
    Best Pract Res Clin Obstet Gynaecol 2016 Jul 25;34:54-65. Epub 2015 Nov 25.
    MRC Centre for Reproductive Health, University of Edinburgh, Edinburgh EH16 4TJ, UK. Electronic address:
    Abnormal uterine bleeding (AUB) is a common and debilitating condition with high direct and indirect costs. AUB frequently co-exists with fibroids, but the relationship between the two remains incompletely understood and in many women the identification of fibroids may be incidental to a menstrual bleeding complaint. A structured approach for establishing the cause using the Fédération International de Gynécologie et d'Obstétrique (FIGO) PALM-COEIN (Polyp, Adenomyosis, Leiomyoma, Malignancy (and hyperplasia), Coagulopathy, Ovulatory disorders, Endometrial, Iatrogenic and Not otherwise classified) classification system will facilitate accurate diagnosis and inform treatment options. Read More

    Uterine artery embolization for heavy menstrual bleeding.
    Womens Health (Lond) 2016 Jan 12;12(1):71-7. Epub 2016 Jan 12.
    Department of Interventional Radiology, Queen Elizabeth University NHS Hospital Glasgow, 1345 Govan Rd, Govan, Glasgow, G51 4TF, UK.
    Uterine artery embolization (UAE) as a treatment option for fibroids was first reported by Ravina in 1995. Although rapidly adopted by enthusiasts, many were skeptical and its introduction varied widely across the globe. It was not until randomized controlled trials and registries were published and national guidance statements issued that UAE was accepted as a safe and proven treatment for fibroids. Read More

    Differences in clinical characteristics for the determination of adenomyosis coexisting with leiomyomas.
    J Obstet Gynaecol Res 2016 Mar 10;42(3):307-12. Epub 2015 Dec 10.
    Faculty of Medicine, Department of Obstetrics and Gynecology, Bezmialem Vakif University, Istanbul, Turkey.
    Aim: The objective of the analysis was to determine the characteristics that distinguish women with adenomyosis and leiomyomas from those with leiomyoma only from a sample who underwent hysterectomy for benign uterine diseases.

    Methods: This retrospective study was based on the analysis of medical records of 75 women with both adenomyosis and uterine leiomyomas and 218 women with leiomyomas only, diagnosed by histologic analysis of uterine specimens.

    Results: Results of multivariate logistic regression analyses showed that women with both adenomyosis and leiomyomas had a higher gravity (odds ratio [OR] 1. Read More

    Safety profile of etifoxine: A French pharmacovigilance survey.
    Fundam Clin Pharmacol 2016 Apr 26;30(2):147-52. Epub 2016 Jan 26.
    Regional Pharmacovigilance Center of Lyon, University Hospitals, 162, avenue Lacassagne, 69003, Lyon, France.
    Etifoxine chlorhydrate is a benzoxazine derivative approved for the treatment of psychosomatic manifestations of anxiety since 1979. Previously labeled adverse drug reactions (ADRs) only include drowsiness, benign cutaneous reactions, and acute hypersensitivity reactions. The objectives were to examine recent data on etifoxine-related ADR by reviewing Individual Case Safety Reports (ICSRs) recorded in France especially unexpected ADRs. Read More

    The HysNiche trial: hysteroscopic resection of uterine caesarean scar defect (niche) in patients with abnormal bleeding, a randomised controlled trial.
    BMC Womens Health 2015 Nov 12;15:103. Epub 2015 Nov 12.
    Department of Obstetrics and Gynaecology, VU medical centre, Amsterdam, Netherlands.
    Background: A caesarean section (CS) can cause a defect or disruption of the myometrium at the site of the uterine scar, called a niche. In recent years, an association between a niche and postmenstrual spotting after a CS has been demonstrated. Hysteroscopic resection of these niches is thought to reduce spotting and menstrual pain. Read More

    Is endometrial ablation protective against endometrial cancer? A retrospective observational study.
    Arch Gynecol Obstet 2016 May 26;293(5):1033-7. Epub 2015 Oct 26.
    Department of Obstetrics and Gynaecology, Bradford Teaching Hospitals NHS Foundation Trust, Bradford, Yorkshire, UK.
    Study Objectives: Endometrial ablation has been increasingly used over the last 30 years to manage patients with dysfunctional uterine bleeding. Of primary concern, however, is the potential of the procedure to mask the presence or delay the diagnosis of endometrial cancer. The aim of this study is to assess the long-term effects of endometrial ablation and its association with the development of endometrial cancer. Read More

    Cervix removal at the time of hysterectomy: factors affecting patients' choice and effect on subsequent sexual function.
    Eur J Obstet Gynecol Reprod Biol 2015 Dec 15;195:67-71. Epub 2015 Oct 15.
    Minimally Invasive Gynecological Surgery Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
    Objectives: To identify factors that influence the decision-making process on the type of hysterectomy (total or supracervical) and the impact of surgery of subsequent sexual function.

    Study Design: A cross-sectional survey was undertaken on 212 women who underwent total laparoscopic hysterectomy (TLH) or laparoscopic supracervical hysterectomy (LSH) for benign conditions at the Division of Minimally Invasive Gynecology at Brigham and Women's Hospital in Boston, MA, USA. We analyzed the factors that patients considered in their decision-making process, their sexual function after surgery and their satisfaction with the surgery overall. Read More

    Evaluation and Management of Adolescents with Abnormal Uterine Bleeding.
    Pediatr Ann 2015 Sep;44(9):e218-22
    The International Federation of Gynecology and Obstetrics and the American Congress of Obstetricians and Gynecologists support the use of new terminology for abnormal uterine bleeding (AUB) to consistently categorize AUB by etiology. The term AUB can be further classified as AUB/heavy menstrual bleeding (HMB) (replacing the term "menorrhagia") or AUB/intermenstrual bleeding (replacing the term "metrorrhagia"). Although many cases of AUB in adolescent women are attributable to immaturity of the hypothalamic-pituitary-ovarian axis, underlying bleeding disorders should be considered in women with AUB/HMB. Read More

    Body mass index does not affect the efficacy or bleeding profile during use of an ultra-low-dose combined oral contraceptive.
    Contraception 2016 Jan 26;93(1):52-7. Epub 2015 Sep 26.
    Eastern Virginia Medical School, Department of Obstetrics and Gynecology, 601 Colley Avenue, Norfolk, VA, 23507-2007, USA. Electronic address:
    Objectives: Safe and effective contraceptive options for obese women are becoming more important due to the obesity epidemic within the United States. This study evaluated the impact of body mass index (BMI) on efficacy, safety and bleeding patterns during use of an ultra-low-dose combined oral contraceptive (COC).

    Study Design: Data are from a Phase 3 clinical efficacy and safety study of an ultra-low-dose COC containing 1. Read More

    Why do niches develop in Caesarean uterine scars? Hypotheses on the aetiology of niche development.
    Hum Reprod 2015 Dec 25;30(12):2695-702. Epub 2015 Sep 25.
    VU University medical Centre, Amsterdam, The Netherlands.
    Caesarean section (CS) results in the occurrence of the phenomenon 'niche'. A 'niche' describes the presence of a hypoechoic area within the myometrium of the lower uterine segment, reflecting a discontinuation of the myometrium at the site of a previous CS. Using gel or saline instillation sonohysterography, a niche is identified in the scar in more than half of the women who had had a CS, most with the uterus closed in one single layer, without closure of the peritoneum. Read More

    Effect of oral contraceptives and doxycycline on endometrial MMP-2 and MMP-9 activity.
    Contraception 2016 Jan 25;93(1):65-9. Epub 2015 Sep 25.
    Oregon Health & Science University, 3181 SW Sam Jackson Park Road, UHN 50, Portland, OR 97239, USA.
    Objectives: To describe the effect of combined oral contraceptives (COCs) on matrix metalloproteinases MMP-2 and MMP-9 activity and compare MMP activity in women taking a COC with or without doxycycline.

    Study Design: Subjects (n=20) underwent endometrial biopsies (1) in the late luteal phase of a baseline cycle prior to initiating COCs, (2) on days 19-21 while taking COCs in a standard 28-day cycle (7-day hormone-free interval) and (3) on days 26-28 while taking active COCs continuously for a 28-day cycle. During the continuous COC cycle, they were randomized to receive daily subantimicrobial dose doxycycline 40mg or placebo. Read More

    Comparison of spironolactone and spironolactone plus metformin in the treatment of polycystic ovary syndrome.
    Gynecol Endocrinol 2016 15;32(1):42-5. Epub 2015 Sep 15.
    a Division of Endocrinology and.
    The aim of this study was to evaluate and compare the effects of spironolactone and spironolactone plus metformin treatments on body mass index (BMI), hirsutism score, hormone levels, and insulin resistance in women with polycystic ovary syndrome (PCOS). Thirty-seven patients with PCOS were randomly assigned to receive spironolactone 100 mg/d (spironolactone group, 18 patients) or spironolactone 100 mg/d plus metformin 2000 mg/d (combination group, 19 patients) for 12 months. BMI, modified Ferriman-Gallway score (FGS), serum levels of regarding hormones, and homeostasis model assessment of insulin resistance (HOMA-IR) index were assessed before and after the treatments. Read More

    Ambulatory medical services utilization for menstrual disorders among female personnel of different medical professions in Taiwan: a nationwide retrospective cohort study.
    BMC Womens Health 2015 Aug 26;15:66. Epub 2015 Aug 26.
    Division of Geriatrics, Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, 2 Minsheng Road, Dalin, Chiayi, 62247, Taiwan.
    Background: Menstrual disorders and their adverse symptoms can have a deleterious effect on both the private and working lives of women. Previous studies indicated that female nurses have elevated risk of menstrual disorders. Moreover, female nurses showed a higher incidence of ambulatory care visit for genitourinary diseases compared with other female medical personnel. Read More

    Unusual Bleeding Due to Riociguat Use in a Patient With Chronic Thromboembolic Pulmonary Hypertension.
    Am J Ther 2016 Sep-Oct;23(5):e1253-4
    1Department of Cardiology, Marmara University Faculty of Medicine, Istanbul, Turkey; and 2Department of Thoracic Surgery, Marmara University School of Medicine, Istanbul, Turkey.
    Riociguat is a new drug prescribed to patients with pulmonary hypertension that reduces the pressure in pulmonary artery by vasodilation. This drug like many other drugs has several side effects, some of which can be serious such as bleeding. Riociguat causes vaginal bleeding by increasing endometrial thickness and blood flow to the endometrium, therefore, should be used with care especially for patients who have history of dysfunctional uterine bleeding. Read More

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