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J Obstet Gynaecol 2019 Apr 9:1-6. Epub 2019 Apr 9.

c HealthPartners North Suburban Family Physicians , Roseville , MN , USA.

Dyspareunia, vaginitis and dysfunctional uterine bleeding (DUB) are common problems which, despite their polygenicity, commonly appear idiopathic and treatment-refractory. Mast cell (MC) activation syndrome (MCAS) is a newly-recognised, prevalent, chronic multisystem polymorbidity of general themes of inflammation ± allergic-type phenomena ± aberrant growth/development in assorted tissues. MCs produce significant quantities of heparin, too. Read More

Gynecol Obstet Fertil Senol 2019 Mar 13. Epub 2019 Mar 13.

Service de gynécologie-obstétrique, CHU de Poitiers, 1, rue de la Milétrie, 86000 Poitiers, France. Electronic address:

The objective of this literature review is to update the recommendations for clinical practice about the diagnosis of pelvic inflammatory disease (PID), microbiologic diagnosis excluded. An adnexal pain or cervical motion tenderness are the signs that allow a positive diagnosis of PID (LE2). Associated signs (fever, leucorrhoea, metrorrhagia) reinforce clinical diagnosis (LE2). Read More

J Gynecol Obstet Hum Reprod 2019 May 23;48(5):319-327. Epub 2019 Feb 23.

Department of Gynaecological Surgery and Oncology, Obstetrics, Lyon Sud University Hospital, Hospices Civils de Lyon, Claude Bernard University Lyon 1, 165 chemin du Grand Revoyet, 69310, Pierre-Bénite, France.

Objectives: Few studies in the literature take into account the WHO's 2014 redefinition of the characteristics of mucinous adenocarcinoma of the uterine cervix. Our objective was to describe the characteristics of a group of these patients.

Material And Methods: This was a retrospective descriptive study of patients diagnosed between 1 January 2005 and 31 May 2016 in three hospitals in Lyon, France. Read More

BMJ Case Rep 2019 Feb 25;12(2). Epub 2019 Feb 25.

Department of Cellular Pathology, New Cross Hospital, Wolverhampton, UK.

Lymphangioleiomyomatosis (LAM) is a rare disease that typically affects women of childbearing age. It most commonly affects the lungs (P-LAM) but can occasionally occur in extra-pulmonary sites (E-LAM). There is a strong association between LAM and the tuberous sclerosis complex (TSC). Read More

Int J Reprod Biomed (Yazd) 2018 Nov;16(11):665-678

Department of Epidemiology and Reproductive Health, Reproductive Epidemiology Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran.

Background: Understanding the prevalence of menstrual disorders has important implications for both health service planning and risk factor epidemiology.

Objective: The aim of this review is to identify and collate studies describing the prevalence of menstrual disorders in Iran.

Materials And Methods: Studies with original data related to the prevalence of menstrual disorders were identified via searching six electronic databases and reviewing citations. Read More

Rev Med Chil 2018 Sep;146(9):1074-1078

Sección Genética Hospital Clínico, Universidad de Chile, Santiago, Chile.

We report a 51-year-old female who had a first episode of thrombocytopenia at 23 years of age during a pregnancy. At the age of fifty, a hysterectomy was indicated due to a metrorrhagia: a platelet count of 21,000/ul was detected. She was treated with eltrombopag with a good response. Read More

J Ethnopharmacol 2019 Apr 26;234:154-171. Epub 2019 Jan 26.

Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, PR China. Electronic address:

Ethnopharmacological Relevance: The plants of genus Liparis comprise approximately 428 species worldwide among these species 52 are widely distributed in China. These plants have long been used in China for the treatment of wound bleeding, detoxifying and inflammatory diseases, such as metrorrhagia, hemoptysis, traumatic hemorrhage, snakebite, and pneumonia.

Aim Of This Review: We intend to summarize traditional uses of Liparis spp. Read More

Gan To Kagaku Ryoho 2018 Dec;45(13):1880-1882

Dept. of Surgery, Tsubame Rosai Hospital.

We reported a case of melena caused by perineal dissemination and treated with radiologic intervention. The patient was a 67-year-old woman, who underwent a partial duodenectomy for duodenal(4th portion)cancer in 2013. The pathological examination revealed that the tumor was tub2>por2 adenocarcinoma, SE, n+(10/20), M0. Read More

CVIR Endovasc 2018 20;1(1):30. Epub 2018 Nov 20.

Department of Radiology, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Via Olgettina 60, 20132 Milan, Italy.

Background: Choriocarcinoma is a highly malignant tumor but with a good prognosis due to the valid response to systemic chemotherapy. We present a case of a young woman affected by a giant pelvic arterio-venous fistula following a metastatic gestational choriocarcinoma, conditioning metrorrhagia and pulmonary embolism, successfully treated by multimodal transcatheter embolization, using a simultaneous transarterial and transvenous approach.

Case Presentation: In a young patient affected by choriocarcinoma and metrorrhagia, a computed tomography showed a giant arterio-venous fistula, pulmonary metastases and embolism. Read More

Nat Prod Res 2018 Dec 23:1-5. Epub 2018 Dec 23.

a College of Xiangya Pharmaceutical Science , Central South University , Changsha , Hunan , China.

The pollen of T. angustifolia, also known as Pu huang in Chinese, has been used for treatment of stranguria, hematuria, dysmenorrhea, metrorrhagia and injuries in China for a long time. Extensive efforts have been directed toward its phytochemical and biological aspects. Read More

Med Sci Monit 2018 Dec 21;24:9317-9323. Epub 2018 Dec 21.

Department of General Surgery, Huaihe Hospital, Kaifeng, Henan, China (mainland).

BACKGROUND Abdominal bleeding is a severe complication of duodenal fistula, but few studies have focused on this problem. The purpose of the present study was to investigate the prevalence of and risk factors for intra-abdominal bleeding in patients with external duodenal fistula. MATERIAL AND METHODS From January 2014 to December 2016, medical records of 97 patients with external duodenal fistula were retrospectively reviewed and analyzed. Read More

Rev Med Liege 2018 Dec;73(12):615-620

Service d'Onco-Hématologie, CHC de Liège, Belgique.

A 65-year old woman presents with a Demons-Meigs syndrome characterized by dyspnea resulting from a transsudative pleural effusion, an important unilateral right ovarian mass and ascites. The diagnosis of a Brenner type histology was obtained after complete surgical removal of ovarian tumor. After discharge the patient entered in a sustained complete response and thus potential cure. Read More

Am J Case Rep 2018 Dec 12;19:1474-1479. Epub 2018 Dec 12.

International Academy of Classical Homeopathy, University of the Aegean, Alonissos, Greece.

BACKGROUND Obesity is one of the leading causes of morbidity and mortality globally and challenging to treat because of the multifactorial etiology and presentation. Individualized homeopathy takes into account factors that led to a patient's health condition and hence may have a role in the treatment of obesity and related co-morbidities; co-morbidities that may arising from the same etiology may respond as a whole to homeopathy treatment. CASE REPORT A 39-year-old Russian female who developed multiple problems after severe emotional stress was treated with individualized classical homeopathic therapy. Read More

Ultrasound Q 2018 Dec;34(4):272-277

Department of Radiology, University of Washington Medical Center, Seattle, WA.

Background: Endometrial polyps are localized overgrowth of glands, stroma, and blood vessels and reported in 13% to 50% of women with dysfunctional uterine bleeding. Transvaginal ultrasound (TVUS) is the initial noninvasive modality of choice for the evaluation of endometrial polyps. The addition of intrauterine contrast by adding saline during saline infusion sonohysterography (SIS) has been reported to improve diagnostic accuracy in detecting of endometrial polyps. Read More

J Obstet Gynaecol Res 2019 Jan 23;45(1):168-175. Epub 2018 Sep 23.

Obstetrics and Gynecology, Tottori University Faculty of Medicine, Yonago, Japan.

Aims: Dydrogesterone is a retro-progesterone preparation widely used for over a half century. We sought to evaluate the efficacy and safety of dydrogesterone in Japanese women with dysmenorrhea.

Methods: This study was conducted as an open-label, single-arm, multicenter study. Read More

J Laparoendosc Adv Surg Tech A 2019 Jan 10;29(1):24-28. Epub 2018 Sep 10.

CAREMUJER Clinic, Sevilla, Spain.

Objectives: The aim was to study technique, complications, and outcomes of transvaginal ultrasound-guided radiofrequency myolysis (TRFAM) of uterine myomas.

Materials And Methods: A prospective observational study of 205 patients with metrorrhagia secondary to type II/III submucosal or intramural cavity-distorting myomas undergoing outpatient TRFAM under sedation between September 2015 and February 2017.

Main Outcome Measures: Intraoperative and postoperative complications, correction of metrorrhagia, patient satisfaction, mean volume of myoma, and hemoglobin level at 1, 3, 6, and 12 months after the procedure. Read More

Int J Gynaecol Obstet 2018 Dec 10;143(3):393-408. Epub 2018 Oct 10.

School of Women's and Children's Health, Royal Hospital for Women, University of New South Wales, Randwick, NSW, Australia.

Background: The International Federation of Gynecology and Obstetrics (FIGO) systems for nomenclature of symptoms of normal and abnormal uterine bleeding (AUB) in the reproductive years (FIGO AUB System 1) and for classification of causes of AUB (FIGO AUB System 2; PALM-COEIN) were first published together in 2011. The purpose was to harmonize the definitions of normal and abnormal bleeding symptoms and to classify and subclassify underlying potential causes of AUB in the reproductive years to facilitate research, education, and clinical care. The systems were designed to be flexible and to be periodically reviewed and modified as appropriate. Read More

Rom J Morphol Embryol 2018 ;59(2):527-531

Department of Obstetrics and Gynecology, University of Medicine and Pharmacy of Craiova, Romania; Department of Obstetrics and Gynecology, "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania;

The prevalence of endometrial cancer among asymptomatic women is rather reduced also due to the absence of a cost-efficient test, as there are no ideal screening examinations for endometrial cancer. Several methods were proposed in medical practice to discover endometrial neoplasia at an early stage, among which: endometrial biopsy, endovaginal ultrasound, targeted biopsy hysteroscopy. This study was made on a group of 38 patients monitored for metrorrhagia in the interval between July 1, 2014-July 1, 2016. Read More

J Reprod Infertil 2018 Jul-Sep;19(3):152-156

Department of Community Medicine, M.S. Ramaiah Medical College, Bangalore, India.

Background: Levonorgestrel is most commonly utilized as an emergency oral contraceptive. Little is known and/or studied about the adverse effects of levonorgestrel, therefore, current investigation was aimed to generate signal for unreported adverse drug reactions of levonorgestrel using disproportionality analysis in food and drug administration adverse events reporting system database.

Methods: In FDA Adverse Events Reporting System (FAERS) database, all adverse event reports for levonorgestrel between January 2006 to June 2015 were identified and disproportionality analysis was conducted for selected adverse events of levonorgestrel using Reporting Odds Ratio, Proportional Reporting Ratio and Information Component with 95% confidence interval. Read More

BMJ Case Rep 2018 Aug 9;2018. Epub 2018 Aug 9.

General Pediatric and Complementary Medicine Physician, Penn Integrative Pediatrics, Houston, Texas, USA.

A 17-year-old girl with a history of dysfunctional uterine bleeding (DUB) and severe dysmenorrhoea was treated with different conventional hormonal therapies for 16 months without improvement.Treatment with traditional Chinese acupuncture was started while she was taking oral contraceptives. She received a total of 27 treatments in 17 weeks. Read More

J Minim Invasive Gynecol 2018 Aug 1. Epub 2018 Aug 1.

Department of Obstetrics and Gynecology, Arnaud de Villeneuve Hospital, University of Montpellier, Montpellier, France (Dr. Crochet).

Study Objective: To evaluate the feasibility of an en-bloc salpingectomy at the time of vaginal hysterectomy for removal of Essure inserts.

Design: Prospective observational study (Canadian Task Force classification II-1).

Setting: Monocenter study at the Conception University Hospital Center, Marseille, France. Read More

BMJ Case Rep 2018 Jul 30;2018. Epub 2018 Jul 30.

Department of O&G, KK Women's and Children's Hospital, Singapore, Singapore.

This case report will discuss an interesting case of a premenopausal woman who presented with an adnexal mass consistent with a leiomyoma on imaging. However, intraoperatively, the mass was thought to be a gastrointestinal stromal tumour but histological diagnosis subsequently confirmed a leiomyoma arising from the small bowel. Read More

Gynecol Endocrinol 2019 Jan 25;35(1):32-35. Epub 2018 Jul 25.

a Department of Medical Science , Università di Trieste , Trieste , Italy.

Disseminated intravascular coagulation (DIC) is a high mortality coagulopathy that leads to simultaneous thrombotic and bleeding problems. It occurs as a complication in different disease as malignancies, obstetrical catastrophes, bacterial sepsis and traumas. We report on an extremely rare case of acute DIC in a patient with misdiagnosed adenomyosis and massive methrorragia which led to acute kidney failure. Read More

Zhonghua Fu Chan Ke Za Zhi 2018 Jun;53(6):409-413

Department of Family Planning, Obstetrics and Gynecology Hospital of Fudan University, Shanghai 200011, China.

To evaluate the efficacy, bleeding profile and safety of low-dose levonorgestrel-releasing intrauterine system (LNG-IUS 8) in Chinese healthy women of childbearing age. A multi-center, open-label, single-arm clinical trial conducted at 16 centres in China enrolled 773 healthy women of childbearing age (mean age 31.6 years old, range 18 to 40 years old) , who demanded contraception, from April 2006 to June 2013. Read More

Cir Cir 2018 ;86(3):270-276

Módulo de Cadera, Miembro Inferior y Remplazo Articular, Servicio de Ortopedia y Traumatología, Hospital Universitario Dr. José Eleuterio González, Universidad Autónoma de Nuevo León, Monterrey, N.L. México.

Antecedentes: El sangrado secundario es una de las principales causas de morbilidad después de la cirugía. El etamsilato se ha utilizado con buenos resultados para disminuir el sangrado en diversas patologías, como metrorragias, sangrado intraventricular, prostatectomías, cirugías de catarata y amigdalectomías. El objetivo de este estudio fue evaluar la efectividad del etamsilato para disminuir el sangrado en la cirugía de reemplazo total de cadera. Read More

J Int Med Res 2018 Aug 4;46(8):3417-3421. Epub 2018 Jun 4.

1 Department of Gynecology, Hebei General Hospital, Hebei, China.

Primary endometrial squamous cell carcinoma is an extremely rare tumor that tends to occur in postmenopausal women. We report on a 33-year-old woman who presented with a history of irregular vaginal bleeding for more than 2 years, and a vaginal mass for more than 1 month. Biopsy of the vaginal mass revealed an invasive poorly differentiated squamous cell carcinoma. Read More

J Obstet Gynaecol Res 2018 Aug 29;44(8):1439-1444. Epub 2018 May 29.

Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, Tokyo, Japan.

Aim: Adenomyosis is a common gynecological disorder that causes dysmenorrhea, hypermenorrhea and metrorrhagia. Previously, we reported that 24 weeks of dienogest treatment is highly effective for pain in symptomatic adenomyosis. Up to present, there is no report that describes treatment of adenomyosis with long-term dienogest administration for more than 2 years. Read More

Am J Health Syst Pharm 2018 Jul 7;75(13):973-977. Epub 2018 May 7.

Department of Pharmacy Practice, St. John Fisher College, Rochester, NY.

Purpose: The potential link between serious or life-threatening bleeding and the use of direct oral anticoagulants (DOACs) was evaluated.

Methods: Qualitative and quantitative reviews of case reports of bleeding events involving dabigatran, rivaroxaban, apixaban, edoxaban, and warfarin through March 31, 2017, were performed. A disproportionality analysis was conducted for each DOAC using an empirical Bayesian approach based on the relative reporting rate. Read More

Indian J Pharmacol 2017 Nov-Dec;49(6):470-471

Department of Dermatology, Nicolina Medical Centre, Apollonia University, "P.Poni" Research Institute of Macromolecular Chemistry, Lasi, Romania.

We present first case report on itraconazole, a drug very commonly used for onychomycosis, used along with simvastatin that caused metrorrhagia. The suggested probable mechanism is the inhibition of steroidogenesis, especially estrogens that resulted in low-estrogen breakthrough bleeding. This article emphasizes the importance of drug interaction check prior the initiation of onychomycosis treatment. Read More

Molecules 2018 Apr 17;23(4). Epub 2018 Apr 17.

College of Pharmacy, Sunchon National University, 255 Jungangno, Suncheon-si 57922, Jeonnam, Korea.

() (Beauv.) Spring (Selaginellaceae) has been used in oriental medicine for the treatment of dysmenorrhea, chronic hepatitis, hyperglycemia, amenorrhea, hematuria, prolapse of the anus and metrorrhagia. In the present study, we isolated two strong anti-inflammatory compounds, the biflavonoids hinokiflavone (H) and 7′--methyl hinokiflavone (mH), from and examined their anti-inflammatory activities in lipopolysaccharide (LPS)-mediated murine macrophages (RAW 264. Read More

J Midlife Health 2018 Jan-Mar;9(1):8-13

Center for Integrative Medicine and Research, AIIMS, New Delhi, India.

Background: Dysfunctional uterine bleeding (DUB) is one of the most common gynecological disorders encountered in women during the reproductive age. Yoga therapy has shown promising benefits in several gynecological disorders.

Methods: Thirty women between the ages of 20 and 40 years with primary DUB were randomly assigned to a yoga ( = 15) and a waitlist control group ( = 15). Read More

Oncol Lett 2018 Mar 16;15(3):3944-3950. Epub 2018 Jan 16.

Key Laboratory of Industrial Fermentation Microbiology of The Ministry of Education, Tianjin Key Laboratory of Industrial Microbiology, College of Biotechnology, Tianjin University of Science and Technology, Tianjin, Hebei 300457, P.R. China.

L. (Great St. Johnswort), which belongs to the Hypericaceae family, has been used for the treatment of hematemesis, metrorrhagia, rheumatism, swelling, stomach ache, abscesses, dysentery and irregular menstruation for >2,000 years in China. Read More

Int J Surg 2018 May 16;53:98-102. Epub 2018 Mar 16.

Assisted Reproduction Unit, Department of Obstetrics and Gynecology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Key Laboratory of Reproductive Dysfunction Management of Zhejiang Province, No. 3 East Qing Chun Road, Hangzhou, 310016, PR China. Electronic address:

Objective: To report on our experience of laparoscopic cornuostomy or cornual repair for cornual heterotopic pregnancy.

Study Design: A single center, retrospective review of patients who were diagnosed as cornual heterotopic pregnancy, which developed after in vitro fertilization and embryo transfer (IVF/ET) between January 2009 and June 2014. All patients were managed by laparoscopic cornuostomy or cornual repair. Read More

Ceska Gynekol Winter 2018;83(1):53-56

Aim: To present a case of a woman diagnosed with intravenous leiomyomatosis of the uterus.

Type Of Study: Case report.

Setting: Department of Obstetrics & Gynaecology, Středomoravská nemocniční a. Read More

Neuro Endocrinol Lett 2018 Feb;38(8):537-543

1st Department of Obstetrics and Gynecology, Medical University of Warsaw, Poland.

Objectives: Abnormal uterine bleeding (AUB) is caused by derangement of physiological processes of tissue growth, shedding and regeneration. It is known that interplay between metalloproteinases (MMP's) and tissue inhibitors of metalloproteinases (TIMP's) may play a crucial role in its occurrence.

Aim: To define if expression of proMMP-2, MMP-2 and TIMP-1 in endometrium of women with AUB is dependent on steroid sex hormone concentration and histopathological picture. Read More

Food Chem Toxicol 2018 Sep 26;119:326-333. Epub 2018 Feb 26.

Institute of Chinese Materia Medica, Henan University, Kaifeng, 475004, China; Kaifeng Key Laboratory of Functional Components in Health Food, Kaifeng, 475004, China. Electronic address:

Flowers of Malus halliana (M. halliana) Koehne have been used as a Chinese traditional medicine to treat metrorrhagia and in our study, its chemical composition and anticoagulant effect were investigated. Five compounds were isolated and identified from M. Read More

Eur J Obstet Gynecol Reprod Biol 2018 Mar 3;222:89-94. Epub 2018 Feb 3.

Academic Unit of Obstetrics and Gynaecology Ospedale Policlinico San Martino, Largo R. Benzi 10, 16132, Genoa, Italy; Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DiNOGMI), University of Genoa, Italy. Electronic address:

Introduction: This patient preference prospective study was designed to compare patients' satisfaction in women with endometriosis treated either by an extended-cycle oral contraception (OC) or by norethindrone acetate (NETA).

Methods: This patient preference prospective study included women of reproductive age with endometriosis. Patients were submitted to one of the following 12 months' treatments: Group A, continuous oral treatment with NETA (2. Read More

Zhongguo Zhong Yao Za Zhi 2017 Dec;42(23):4445-4450

China Academy of Chinese Medical Sciences, Beijing 100700, China.

Kidney deficiency and blood stasis is the main cause of ovulatory dysfunctional infertility. Kidney deficiency is the main pathological mechanism. Blood stasis is the main pathological manifestation, and it is an important factor throughout. Read More

Rev Bras Ginecol Obstet 2018 Jan 16;40(1):47-52. Epub 2018 Jan 16.

Serviço de Radiologia, Instituto Português Oncologia do Porto Francisco Gentil, Porto, Portugal.

Vaginal cancer is a rare entity. The evidence on its management resides mostly in clinical cases or small case series. Of the histological types, the most frequent is the squamous cell carcinoma, followed by adenocarcinoma. Read More

Croat Med J 2017 Dec;58(6):416-423

Zlatko Trobonjača, Department of Physiology and Immunology, University of Rijeka School of Medicine, Braće Branchetta 20, 51000 Rijeka, Croatia,

We presented an extremely severe case of tuberous sclerosis complex (TSC) in a female patient with recurring, life-threatening bleeding complications related to renal angiomyolipomas. Massive intratumoral hemorrhage required surgical removal of both angiomyolipomatous kidneys and kidney transplantation. During the follow-up period, the patient developed severe metrorrhagia that eventually led to hysterectomy and salpingo-oophorectomy. Read More

Int J Surg Pathol 2018 Apr 18;26(2):104-119. Epub 2017 Dec 18.

2 Rutgers New Jersey Medical School, Newark, NJ, USA.

From 1861 to 1962, clinicopathologic research tried to explain the association of abnormal uterine bleeding with uterine enlargement. The etiology was theorized as metropathy, suggesting that myometrial dysfunction may predispose to abnormal uterine bleeding. Research reached a nadir in 1962, when a major review dismissed myometrial hypertrophy as a plausible explanation after prior rejections of the theories of chronic myometritis, fibrosis uteri, and subinvolution as causes of bleeding. Read More

Arch Gynecol Obstet 2018 02 8;297(2):409-414. Epub 2017 Dec 8.

Department of Obstetrics and Gynaecology, Freiburg Medical School, University of Freiburg, Hugstetter Strasse 55, 79106, Freiburg, Germany.

Objective: To compare operating time and blood loss in patients undergoing total laparoscopic hysterectomies (TLH) for benign conditions with either the Marseal™ IQ 5 mm (MS) or the Ligasure™ 5 mm (LS) vessel-sealing device.

Design And Setting: A randomized controlled clinical trial (RCT) in two German gynecology departments.

Patients: 74 patients scheduled to undergo TLH for a symptomatic fibroid uterus, adenomyosis or severe meno-metrorrhagia. Read More

Respir Med 2017 Sep 19;130:55-60. Epub 2017 Jul 19.

School and Chair of Allergology and Clinical Immunology, Department of Emergency and Organ Transplantation, University of Bari Aldo Moro, Italy.

Background: Randomized Controlled Trials showed that omalizumab exhibited a good safety and tolerability profile in patients with moderate-to-severe asthma. However, safety data of long-term treatment with omalizumab are scarce. Our aim was to assess the safety of omalizumab in patients under long-term treatment in a real-life setting. Read More

World J Oncol 2017 Jun 9;8(3):76-80. Epub 2017 Jun 9.

Gynecology and Obstetrics Clinic, Istanbul Training and Research Hospital, Istanbul, Turkey.

Background: Uterine smooth muscle tumor of uncertain malignant potential (STUMP) is rare tumor, and regarded as sub-classification in uterine smooth muscle tumors between benign and malignant criteria. In this study, we evaluated characteristics of cases with STUMP diagnosis in a 10-year period.

Methods: We retrospectively evaluated medical records of patients with histopathological STUMP diagnosis in Istanbul Training and Research Hospital, a tertiary center. Read More

Minerva Ginecol 2017 Dec;69(6):618-630

Unit of Obstetrics and Gynecology, Department of Human Pathology in Adulthood and Childhood "G. Barresi", University of Messina, Messina, Italy.

Abnormal uterine bleeding (AUB) is defined as any atypical genital bleeding originating from the uterine cavity, without the characteristics of normal menstrual period. AUB is an important symptom both for adolescents and their parents, and it usually leads to a state of anxiety. Although about 95% of AUB could be considered as a dysfunctional disorder, AUB requires well-defined diagnostic procedures in order to detect a physical cause, ruling out complex or systemic diseases, including oncological ones. Read More

G Ital Dermatol Venereol 2017 12;152(6):686-688

Department of Pathological Anatomy, Schiavonia, Padua, Italy.

Arch Iran Med 2017 Sep;20(9):558-563

Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Background: Abnormal uterine bleeding (AUB) is one of the most common gynecologic complaints among reproductive-age women. The purpose of this study was to investigate the prevalence of AUB and its related factors among reproductive age Iranian women.

Methods: A population-based cross-sectional study was conducted on 1393 women aged 15 - 45 years who participated in the Tehran Lipid and Glucose Study in 2009 - 2012. Read More

J Ethnopharmacol 2018 Jan 28;211:278-284. Epub 2017 Sep 28.

College of Pharmaceutical Sciences & Chinese Medicine, Southwest University, Chongqing 400715, China; Chongqing Key Laboratory of New Drug Screening from Traditional Chinese Medicine, Chongqing 400715, China; Pharmacology of Chinese Materia Medica, The Key Discipline Constructed by the State Administrative of Traditional Chinese Medicine, Chongqing 400715, China. Electronic address:

Ethnopharmacological Relevance: Zi-Yin-Tiao-Jing granule (ZG) is a traditional Chinese medicine compound preparation for perimenopausal dysfunctional uterine bleeding. It is made from 9 Chinese crude drugs based on a modified traditional Chinese prescription recorded in Fu Qingzhu Nvke as Guben Zhibeng Tang.

Aim Of The Study: This study aimed to investigate the hemostasis and uterine contraction promoting effect of quality controlled ZG extract on animals as a preclinical study. Read More

Br Med Bull 2017 09;123(1):103-114

MRC Centre for Reproductive Health, University of Edinburgh.

Introduction: It is not uncommon for a woman to suffer from abnormal uterine bleeding (AUB) or heavy menstrual bleeding (HMB) at some point during her lifetime. Once pathology is excluded, in practice, management needs to be individualised, taking into account the improvement of the woman's symptoms and quality of life.

Sources Of Data: Peer-reviewed journals, governmental and professional society publications. Read More