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Eur Heart J Case Rep 2021 Apr 21;5(4):ytab120. Epub 2021 Apr 21.

Department of cardiology, Heart Centre OLVG, Oosterparkstraat 9, 1091 AC Amsterdam, the Netherlands.

Background: Non-bacterial thrombotic endocarditis (NBTE) is a rare form of endocarditis notably described in patients with advanced malignancy and auto-immune diseases. It is characterized by the formation of sterile, fibrin-containing vegetations on cardiac endothelium, in the absence of positive blood cultures. It is predominantly located on the mitral- and aortic valve (AV). Read More

J Ethnopharmacol 2021 Jun 1;278:114275. Epub 2021 Jun 1.

Research Center for Traditional Chinese Medicine of Lingnan (Southern China), Jinan University, Guangzhou, 510632, Guangdong, China; National Engineering Research Center for Modernization of Traditional Chinese Medicine Lingnan Resources Branch, Guangzhou, 510632, Guangdong, China; Guangdong Key Lab of Traditional Chinese Medicine Information Technology, Guangzhou, 510632, Guangdong, China. Electronic address:

Ethnopharmacological Relevance: A common view in traditional Chinese medicine (TCM) theory is that "processing can alter the efficacy of crude drugs". The clinical usage of some processed products may have already changed greatly over time during the development of modern scientific analysis. Therefore, the view of "processing can alter the efficacy of crude drugs" should be confirmed by comparative studies. Read More

Sichuan Da Xue Xue Bao Yi Xue Ban 2021 May;52(3):534-538

Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu 610041, China.

The 12-year-old patient was admitted to the hospital on September 19, 2019 for "vaginal bleeding for 2 months and pelvic mass to be diagnosed". The patient and her family explicitly denied any previous history of diethylstilbestrol exposure. After admission, relevant examinations were conducted and hysteroscopic exploration was performed under general anesthesia. Read More

Contraception 2021 May 14. Epub 2021 May 14.

Department of Obstetrics and Gynecology, Eastern Virginia Medical School, Norfolk, Virginia, USA.

Objective: To assess efficacy, cycle control, and safety of an oral contraceptive containing estetrol (E4) 15mg and drospirenone (DRSP) 3mg.

Study Design: Women aged 16-50 years with a body mass index ≤35 kg/m enrolled in this multicenter, open-label, 13-cycle, phase 3 trial evaluating E4/DRSP in a 24-active/4-placebo regimen. Follow-up was scheduled at Cycles 2, 4, 7, and 10 and within 3 weeks of completing cycle 13. Read More

J Minim Invasive Gynecol 2021 May 13. Epub 2021 May 13.

Department of Obstetrics & Gynecology, Western University, London, Ontario, Canada (all authors).. Electronic address:

Study Objectives: Endometrial ablation (EA) is an alternative to hysterectomy for the management of heavy menstrual bleeding; however, EA is not without risk. Our objective was to determine complication rates in women undergoing EA in the province of Ontario over a 15-year time period. The primary outcome was a composite of multiple complications within 30 to 180 days of surgery. Read More

Am J Case Rep 2021 Apr 22;22:e929598. Epub 2021 Apr 22.

Department of Hematology, Hospital Roberto del Río, Santiago, Chile.

BACKGROUND People with hemophilia A have shown osteomuscular complications that have a significant impact on their quality of life (QoL) and on health care costs. Patients with hemophilia A with inhibitors living in developing countries such as Chile face a high disease and treatment burden. Emicizumab, a humanized bispecific monoclonal antibody, is associated with improvements in QoL and reduction in the financial impact of the disease related to treatment. Read More

J Ethnopharmacol 2021 Jul 20;275:114114. Epub 2021 Apr 20.

National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, 100700, China. Electronic address:

Ethnopharmacological Relevance: As one of the first plants used by ancient people, cannabis has been used for medicinal purposes for thousands of years. The long history of medicinal cannabis use contrasts with the paucity of archaeobotanical records. Moreover, physical evidence of medicinal cannabis use in a secular context is much rarer than evidence of medicinal cannabis use in religious or ritual activities, which impedes our understanding of the history of medicinal cannabis use. Read More

Ginekol Pol 2021 Mar 23. Epub 2021 Mar 23.

Cukurova University, Adana, Turkey.

Objectives: To evaluate the FIGO's novel classification system versus the classic terminology in patients with abnormal uterine bleeding.

Material And Methods: A retrospective study was carried out between August 2015 and September 2019 in the Health Sciences University Gazi Yaşargil Training and Research Hospital. The pathology reports of the patients were classified according to the PALM-COEIN method and were compared with classical terminology. Read More

Pan Afr Med J 2020 2;37:301. Epub 2020 Dec 2.

Service de Gynécologie Obstétrique, Centre de Maternité et Néonatologie de Monastir, Centre Hospitalier Universitaire Fattouma Bourguiba Monastir, Université de Monastir, Monastir, Tunisie.

Endometrial stromal sarcomas are rare tumors affecting young women. Diagnosis is most often made after surgery. We here report the case of a 22-year-old girl admitted with pelvic pain associated with metrorrhagias. Read More

J Obstet Gynaecol Res 2021 Apr 15;47(4):1433-1440. Epub 2021 Feb 15.

Department of Obstetrics, Gynecology and Molecular Reproductive Science, Yokohama City University Graduate School of Medicine, Yokohama, Japan.

Aim: Dienogest (DNG) is highly effective for relieving pain caused by endometriosis and adenomyosis. However, women with severe uterine swelling due to adenomyosis who take DNG usually experience metrorrhagia. This study aimed to examine the safety of DNG usage in women with adenomyosis. Read More

Adv Biomed Res 2020 30;9:58. Epub 2020 Oct 30.

Department of Obstetrics and Gynecology, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.

Background: Postmenopausal bleeding might occur due to many benign and malignant underlying diseases. Differentiating between these diseases poses a great importance. This study was designed to compare the diagnostic value of pipelle endometrial sampling and curettage in patients with postmenopausal bleeding. Read More

Ear Nose Throat J 2021 Jan 8:145561320983943. Epub 2021 Jan 8.

Department of Otorhinolaryngology, Rush Sinus Program, 2468Rush University Medical Center, Chicago, IL, USA.

Metastatic skull base malignancies infrequently occur but, when present, typically arise from breast malignancies. Pterygopalatine fossa (PPF) metastasis of any malignancy is further seldom reported, and metastasis of gynecologic malignancies to the PPF has not been previously described in the literature. We present a single case of a 42-year-old female with the first likely case of high-grade endometrial sarcoma metastatic to the PPF. Read More

Pediatr Blood Cancer 2021 Mar 27;68(3):e28867. Epub 2020 Dec 27.

Vascular Anomalies Unit, Department of Pediatric Surgery, Children's Hospital La Paz, Madrid, Spain.

Introduction: Sirolimus has become a pillar in the treatment of vascular anomalies due to its inhibition of the mammalian target of rapamycin (mTOR). Adverse effects include metabolic and hematologic disorders among others, although menstrual disorders have not been well described.

Materials And Methods: Retrospective review of patients with vascular anomalies on sirolimus treatment was performed. Read More

Med Glas (Zenica) 2021 02;18(1):1-6

Clinic for Gynaecology and Obstetrics, University Clinical Centre Tuzla, Tuzla, Bosnia and Herzegovina.

Balneo-gynaecological treatment methods include external bath hydrotherapy, sedentary baths and topical dressings/cataplasm, and internal (intravaginal or intrarectal use of peloids and mineral water). Hyperosmolar thermal spas have been very popular in the treatment of infertility due to the improvement of symptoms of chronic pelvic pain, endometriosis, chronic vascular and inflammatory pelvic diseases. Acute pelvic inflammatory syndrome is a contraindication for balneo-hydrotherapy while hyperthermal hydrotherapy is contraindicated in endometriosis and neurovegetative dystonia due to the stimulation of hyperemia, which worsens the clinical picture. Read More

J Gynecol Obstet Hum Reprod 2021 Jan 17;50(1):101993. Epub 2020 Nov 17.

Department of Gynecology and Obstetrics, Lariboisiere Hospital, Paris, France.

Breast cancer is the leading cause of cancer death in women, and most breast cancer related deaths are due to metastases. Uterine metastases from breast cancer are uncommon and rarely reported in the literature. We described the case of a 50 years-old-woman who developed a uterine metastasis, 6 years after the diagnosis of an invasive ductal breast carcinoma. Read More

Chin Med 2020 23;15:113. Epub 2020 Oct 23.

Department of Clinical Chinese Pharmacy, School of Chinese Materia Medica, Beijing University of Chinese Medicine, No. 11 of North Three-ring East Road, Chao Yang District, Beijing, 100102 China.

Background: Yuzhi Zhixue Granule (YZG) is a traditional Chinese patent medicine for treating excessive menstrual flow caused by ovulatory dysfunctional uterine bleeding (ODUB) accompanied by heat syndrome. However, the underlying molecular mechanisms, potential targets, and active ingredients of this prescription are still unknown. Therefore, it is imperative to explore the molecular mechanism of YZG. Read More

Sci Rep 2020 10 15;10(1):17424. Epub 2020 Oct 15.

Department of Obstetrics and Gynaecology, Amsterdam University Medical Centers, Amsterdam Reproduction and Development Research Institute, Amsterdam, The Netherlands.

This study aimed to develop and validate a model for the preoperative prediction of the effectiveness of hysteroscopic resection of a uterine cesarean niche in patients with postmenstrual spotting. The predictive model was developed in a primary prospective cohort consisting of 208 patients with niche treated by hysteroscopic resection. Multivariable logistic regression analysis was performed to develop the predictive model, which incorporated preoperative menstrual characteristics and magnetic resonance imaging (MRI) findings. Read More

Minim Invasive Ther Allied Technol 2020 Oct 12:1-6. Epub 2020 Oct 12.

Department of Woman, Child and General and Specialized Surgery, University of Campania "Luigi Vanvitelli", Naples, Italy.

Objective: This study aimed to analyze the effects of a six-month therapy with ulipristal acetate (UPA) on myoma size and endometrial thickness in premenopausal women.

Material And Methods: Seventy-four women undergoing conservative therapy with UPA were enrolled for this study. All women underwent transvaginal ultrasound evaluation to assess the endometrial thickness, and the number and size of myomas at the beginning and after six months. Read More

Bull Cancer 2020 Dec 6;107(12):1221-1232. Epub 2020 Oct 6.

Département de chirurgie gynécologique, clinique Mathilde, Boulevard de l'Europe, Rouen, France.

Introduction: Non endometrioid endometrial cancer are infrequent and have poor prognosis. The aim of the study was to evaluate non endometrioid endometrial cancer managment by evaluating endometrial cancer guidelines application.

Material And Methods: This multicentric retrospective study enrolled non endometrioid endometrial cancer between January 2009 to December 2019. Read More

J Nepal Health Res Counc 2020 Sep 7;18(2):248-252. Epub 2020 Sep 7.

Department of Obstetrics and Gynecology, Kathmandu Model Hospital, Nepal.

Background: Abnormal uterine bleeding is defined as any bleeding outside of normal menstruation pattern with excessive duration, frequency, and amount and it is a common problem among women of reproductive age group with varied presentations. The aim of the study was to correlate the histopathological finding in patients with abnormal dysfunctional uterine bleeding with the presenting clinical feature.

Methods: A prospective cross sectional study was carried out at Paropakar Maternity and Women's Hospital, Thapathali, Kathmandu during the period of one year (February 2019 to January 2020). Read More

J Minim Invasive Gynecol 2021 03 11;28(3):389-390. Epub 2020 Sep 11.

Department of Gynecology and Obstetrics, Hospital da Luz, Lisbon, Portugal (all authors).

Study Objective: To describe the surgical treatment of a uterine isthmocele.

Design: Demonstration of the laparoscopic technique with narrated video footage.

Setting: Cesarean section rate has been increasing despite the World Health Organization's recommendation of a maximum 15%, with some countries reaching rates as high as 50%. Read More

Fertil Steril 2021 Feb 7;115(2):397-405. Epub 2020 Sep 7.

Department of Obstetrics and Gynecology, Tottori University Faculty of Medicine, Yonago, Japan.

Objective: To evaluate the efficacy and safety of three dose levels of relugolix, a gonadotropin-releasing hormone receptor antagonist, compared with placebo and leuprorelin in women with endometriosis-associated pain.

Design: Phase 2, multicenter, randomized, double-blind, placebo-controlled study.

Setting: Hospitals and clinics. Read More

Expert Rev Clin Pharmacol 2020 Oct 21;13(10):1103-1123. Epub 2020 Sep 21.

Department of Maternal and Child Health, Gynecology and Urology, Sapienza University of Rome , Rome, Italy.

Introduction: The contraceptive activity of synthetic progestins is mediated through three basic mechanisms: (a) An anti-gonadotrophic action leading to the inhibition of ovulation; (b) Changes in cervical mucus characteristics that inhibit sperm penetration and (c) desynchronization of the endometrial picture necessary for implantation.

Areas Covered: Mechanisms involved in the progestin-induced endometrium desynchronization are individually reviewed for each of the routes of administration and, whenever possible, by individual members of the various families of synthetic progestin derivatives.

Expert Opinion: For contraceptive purposes, progestins are today administered through several routes: orally, as injections, subdermally and via the vagina or the uterine cavity. Read More

BJOG 2021 04 2;128(5):879. Epub 2020 Oct 2.

Monash Women's, Monash Health, Clayton, Vic., Australia.

Lancet Infect Dis 2021 02 3;21(2):263-274. Epub 2020 Sep 3.

Vaccine Research and Development, Pfizer, Pearl River, NY, USA.

Background: Group B streptococcus (GBS) is a major cause of invasive disease in young infants. Infants born to women with sufficient pre-existing anti-GBS capsular IgG antibodies are at reduced risk of GBS disease, making maternal immunisation a potential strategy for prevention. We aimed to assess the safety and immunogenicity of a novel hexavalent (serotypes Ia, Ib, II, III, IV, and V) GBS conjugate vaccine (GBS6). Read More

Molecules 2020 Aug 17;25(16). Epub 2020 Aug 17.

Research Center for Traditional Chinese Medicine of Lingnan (Southern China), Jinan University, Guangzhou 510632, China.

Schizonepetae Spica (SS) is commonly used for treating colds, fevers, bloody stool and metrorrhagia in China. To treat colds and fevers, traditional Chinese medicine doctors often use raw SS, while to treat bloody stool and metrorrhagia, they usually use Schizonepetae Spica Carbonisata (SSC; raw SS processed by stir-frying until carbonization). However, there have been limited investigations designed to uncover the mechanism of stir-fry processing. Read More

Int J Gynaecol Obstet 2020 Dec 19;151(3):347-354. Epub 2020 Sep 19.

Endocrinology Research Centre, Moscow, Russia.

Objective: To evaluate the effectiveness of triptorelin for the treatment of adenomyosis, the benign invasion of endometrial tissue into the myometrium, as a fertility-preserving alternative to the gold standard hysterectomy.

Methods: In this multicenter, open-label, observational study in Russia, performed from November 3, 2011, to August 24, 2015, we assessed the efficacy and safety of triptorelin 3.75 mg administered intramuscularly every 28 days in Russian women who were gonadotropin-releasing hormone agonist treatment-naïve, aged 25-40 years, and had a diagnosis of endometriosis or adenomyosis with heavy menstrual bleeding. Read More

Wiad Lek 2020 ;73(7):1420-1426

Public Non-Profit Organization Of The Izium City Council «Сentral City Hospital Of Sandy Mother Of God», Izium, Ukraine.

Objective: Introduction: Ovarian tumours are an actual problem of present-day medicine, being one of the most difficult sections of modern oncology. The majority of ovarian tumours are of epithelial origin. The ovarian Brenner tumour represents a rare epithelial ovarian neoplasm and accounts for 1-2% of all ovarian neoplasms. Read More

Ultrasound Obstet Gynecol 2020 Oct 14;56(4):506-515. Epub 2020 Sep 14.

Department of Obstetrics and Gynecology, Clinica Universidad de Navarra, Pamplona, Spain.

Objective: To compare the diagnostic performance of two-dimensional transvaginal sonography (TVS) and saline contrast sonohysterography (SCSH) for the diagnosis of endometrial polyps in studies that used both tests in the same group of patients.

Methods: This was a systematic review and meta-analysis. An extensive search was conducted of Medline (PubMed), Cochrane Library and Web of Science, for studies comparing the diagnostic performance of TVS and SCSH for identifying endometrial polyps, published between January 1990 and December 2019, that reported a definition of endometrial polyp on TVS and SCSH and used pathologic analysis as the reference standard. Read More

Best Pract Res Clin Obstet Gynaecol 2020 Nov 5;69:62-73. Epub 2020 Jun 5.

Gynaecology & Medical Education, University of Glasgow, UK.

This chapter explores the role of progesterone and progestogens in the management of abnormal uterine bleeding (AUB). Progestogens are used to regulate intermenstrual bleeding and decrease heavy menstrual bleeding (HMB) in women of reproductive age or who are perimenopausal. In menopausal women, progesterones and progestogens prevent endometrial hyperplasia and aim to reduce the development of endometrial cancer. Read More