423,777 results match your criteria Dynamics [Journal]


Growth dynamics of InAs/InP nanowire heterostructures by Au-assisted chemical beam epitaxy.

Nanotechnology 2018 Dec 11. Epub 2018 Dec 11.

NEST, Scuola Normale Superiore, Istituto Nanoscienze - CNR, 56126 Pisa, Pisa, I56127, ITALY.

The steady-state chemical composition of the In/Au alloy nanoparticles during isothermal growth of Au-assisted InAs and InP nanowires is different for the two materials. Therefore, when switching from one material to the other, to grow axial nanowire heterostructures, transient effects dominate during the time period of the nanoparticle reconfiguration. As a consequence, the precise control of the thickness of thin InP and InAs segments, which is fundamental for the realization of quantum dot structures and superlattices, can be very challenging. Read More

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December 2018

Polymer spreading on substrates with nanoscale grooves using molecular dynamics.

Nanotechnology 2018 Dec 11. Epub 2018 Dec 11.

University of Utah, Salt Lake City, Utah, UNITED STATES.

Understanding how liquid polymer interacts with and spreads on surfaces with nanoscale texture features is crucial for designing complex nanoscale systems. We use molecular dynamics to simulate different types of polymer as they spread on substrates with a single nanoscale groove. We study how groove design affects the potential energy of a substrate and how this governs polymer spreading and orientation. Read More

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December 2018

Conformational and solution dynamics of hemoglobin (Hb) in presence of a cleavable gemini surfactant: Insights from spectroscopy, atomic force microscopy, molecular docking and density functional theory.

J Colloid Interface Sci 2018 Dec 3;538:489-498. Epub 2018 Dec 3.

Department of Chemistry, Arba Minch University, Ethiopia.

Herein, we have explored the conformational alterations of hemoglobin (Hb) in presence of a cleavable gemini surfactant (C16-C4O2-C16). The concerned surfactant was found to induce significant structural perturbations in Hb. UV-vis spectroscopy, steady-state/time-resolved fluorescence, and other utilized techniques have authenticated the complexation of Hb with the gemini surfactant. Read More

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December 2018

Molecular docking, molecular dynamics simulations and QSAR studies on some of 2-arylethenylquinoline derivatives for inhibition of Alzheimer's amyloid-beta aggregation: Insight into mechanism of interactions and parameters for design of new inhibitors.

J Mol Graph Model 2018 Dec 4;87:129-143. Epub 2018 Dec 4.

Chemistry Department, Faculty of Science, Shahid Bahonar University of Kerman, Kerman, Iran. Electronic address:

Alzheimer's disease is characterized using amyloid-beta (Aβ) aggregation. The present work was carried out to extend and design a novel quantitative structure-activity relationship (QSAR) model on inhibition efficiency of some of new 2-arylethenylquinoline derivatives against the Aβ peptide aggregation. The QSAR study, molecular docking and molecular dynamics (MD) simulations were performed to explore the influence of the structural features and investigate the molecular mechanism of ligands interactions with the Aβ peptide. Read More

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December 2018
1 Read

Interacted mechanism of functional groups in ligand targeted with folate receptor via docking, molecular dynamic and MM/PBSA.

J Mol Graph Model 2018 Dec 5;87:121-128. Epub 2018 Dec 5.

School of Science, TianJin ChengJian University, Tianjin, China.

Twenty novel compounds with different functional groups (-COOH, -OH, -NH2 and -CH3) were designed to study the interaction mechanism of ligands with folate receptors (FRs). The optimized structure and the dipole moment of the novel compounds were calculated by a density functional tight-binding method (DFTB). The binding mechanism of the compounds with FRs was studied by molecular docking, molecular dynamic (MD) simulations and MM/PBSA free energy calculations. Read More

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December 2018

Mathematical analysis of a tumour-immune interaction model: A moving boundary problem.

Math Biosci 2018 Dec 8. Epub 2018 Dec 8.

Department of Mathematical Sciences, Stellenbosch University, Private Bag X1 Matieland, 7602, South Africa. Electronic address:

A spatio-temporal mathematical model, in the form of a moving boundary problem, to explain cancer dormancy is developed. Analysis of the model is carried out for both temporal and spatio-temporal cases. Stability analysis and numerical simulations of the temporal model replicate experimental observations of immune-induced tumour dormancy. Read More

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December 2018

Microbiota modulation by eating patterns and diet composition: impact on food intake.

Am J Physiol Regul Integr Comp Physiol 2018 Dec 19;315(6):R1254-R1260. Epub 2018 Sep 19.

Foods and Nutrition, University of Georgia , Athens, Georgia.

There is accumulating evidence that the gut microbiota and its composition dynamics play a crucial role in regulating the host physiological functions and behavior. Diet composition is the primary modulator of bacterial richness and abundance in the gastrointestinal (GI) tract. Macronutrient (fat, sugar, and protein) and fiber contents are especially important in determining microbiota composition and its effect on health outcomes and behavior. Read More

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December 2018
1 Read

The role of sleeping sites in the predator-prey dynamics of leopards and olive baboons.

Am J Primatol 2018 Dec;80(12):e22932

Department of Anthropology, University of California, Davis, California.

Predation is widely recognized as an important selective pressure on prey animals such as baboons (Papio spp.), which face high leopard (Panthera pardus) predation risk, particularly at night. Baboons regularly sleep on cliff faces and in trees at night, ostensibly to avoid such predators. Read More

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December 2018
2 Reads

Trust, Money, and Power: Life Cycle Dynamics in Alliances Between Management Partners and Accountable Care Organizations.

Milbank Q 2018 Dec;96(4):755-781

Gillings School of Public Health, University of North Carolina at Chapel Hill.

Policy Points Accountable care organizations (ACOs) form alliances with management partners to access financial, technical, and managerial support. Alliances between ACOs and management partners are subject to destabilizing tension around decision-making authority, distribution of shared savings, and conflicting goals and values. Management partners may serve either as trainers, ultimately breaking off from the ACO, or as central drivers of the ACO. Read More

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December 2018

Anti-proliferative and anti-malarial activities of spiroisoxazoline analogues of artemisinin.

Arch Pharm (Weinheim) 2018 Dec 10:e1800192. Epub 2018 Dec 10.

Department of Chemistry, School of Chemical and Life Science, Jamia Hamdard, New Delhi, India.

A series of spiroisoxazoline analogues of artemisinin was synthesized by employing 1,3-dipolar cycloaddition between various in situ generated nitrile oxides and artemisitene. All the synthesized compounds were tested for their anti-proliferative and anti-malarial activities. Among the compounds tested, compound 11a was found to be potent against the HCT-15 cancer cell line with IC  = 4. Read More

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December 2018
1 Read

Hematopoietic cell-specific lyn substrate (HCLS1 or HS1): A versatile actin-binding protein in leukocytes.

J Leukoc Biol 2018 Dec 11. Epub 2018 Dec 11.

Department of Molecular Biomedicine, CINVESTAV-IPN, Mexico City, Mexico.

Leukocytes are constantly produced in the bone marrow and released into the circulation. Many different leukocyte subpopulations exist that exert distinct functions. Leukocytes are recruited to sites of inflammation and combat the cause of inflammation via many different effector functions. Read More

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December 2018

Homeostatic maintenance of non-structural carbohydrates during the 2015-2016 El Niño drought across a tropical forest precipitation gradient.

Plant Cell Environ 2018 Dec 11. Epub 2018 Dec 11.

Earth and Environmental Sciences Area, Lawrence Berkeley National Laboratory, Berkeley, CA, 94720, USA.

Non-structural carbohydrates (NSCs) are essential for maintenance of plant metabolism, and may be sensitive to both short- and long-term climatic variation. NSC variation in moist tropical forests has rarely been studied, so regulation of NSCs in these systems is poorly understood. We measured foliar and branch NSC content in 23 tree species at three sites located across a large precipitation gradient in Panama during the 2015-2016 El Niño to examine how short- and long-term climatic variation impact carbohydrate dynamics. Read More

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December 2018

Novel approach to improve progesterone hydroxylation selectivity by CYP106A2 via rational design of adrenodoxin binding.

FEBS J 2018 Dec 7. Epub 2018 Dec 7.

Department of Biochemistry, Saarland University, Campus B2.2, 66123, Saarbrücken, Germany.

Bacterial P450s have considerable potential for biotechnological applications. The P450, CYP106A2, from Bacillus megaterium ATCC 13368 converts progesterone to several hydroxylated products that are important precursors for pharmaceutical substances. As high yields of monohydroxylated products are required for biotechnological processes, improving this conversion is of considerable interest. Read More

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December 2018

A multi-step virtual screening protocol for identification of novel non-acidic microsomal prostaglandin E2 synthase-1 (mPGES-1) inhibitors.

ChemMedChem 2018 Dec 11. Epub 2018 Dec 11.

Gazi Universitesi Eczacilik Fakultesi, Pharmaceutical Chemistry, Tac Sokak No 3, 06580, Ankara, TURKEY.

Microsomal prostaglandin E2 synthase-1 (mPGES-1) is considered as potential therapeutic target for treatment of inflammatory diseases and certain types of cancer. In order to capture novel scaffolds for mPGES-1 inhibition, we applied a virtual screening protocol comprising molecular docking, fingerprints-based clustering with diversity-based selection, protein-ligand interactions fingerprints, and molecular dynamics (MD) simulations with Molecular Mechanic-Poisson Boltzmann Surface Area (MM-PBSA) calculation. The hits identified were carefully analyzed to ensure the selection of novel scaffolds, which make stable interactions with key residues in the mPGES-1 binding pocket and inhibit the catalytic activity of the enzyme. Read More

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December 2018

Nanoplumbing with 2D Metamaterials.

Small 2018 Dec 11:e1803478. Epub 2018 Dec 11.

NC State University, Raleigh, NC, 27695-8202, USA.

Complex manipulations of DNA in a nanofluidic device require channels with branches and junctions. However, the dynamic response of DNA in such nanofluidic networks is relatively unexplored. Here, the transport of DNA in a 2D metamaterial made by arrays of nanochannel junctions is investigated. Read More

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December 2018

Chromatin dynamics governed by a set of nuclear structural proteins.

Genes Chromosomes Cancer 2018 Dec 9. Epub 2018 Dec 9.

Physics Department & Nanotechnology Institute, Bar Ilan University, Ramat Gan, Israel.

During the past three decades, the study of nuclear and chromatin organization has become of great interest. The organization and dynamics of chromatin are directly responsible for many functions including gene regulation, genome replication, and maintenance. In order to better understand the details of these mechanisms, we need to understand the role of specific proteins that take part in these processes. Read More

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December 2018

Its all about connections: hubs and invasion in habitat networks.

Ecol Lett 2018 Dec 9. Epub 2018 Dec 9.

Université Côte d'Azur, INRA, CNRS, ISA, 06900, Sophia Antipolis, France.

During the early stages of invasion, the interaction between the features of the invaded landscape, notably its spatial structure, and the internal dynamics of an introduced population has a crucial impact on establishment and spread. By approximating introduction areas as networks of patches linked by dispersal, we characterised their spatial structure with specific metrics and tested their impact on two essential steps of the invasion process: establishment and spread. By combining simulations with experimental introductions of Trichogramma chilonis (Hymenoptera: Trichogrammatidae) in artificial laboratory microcosms, we demonstrated that spread was hindered by clusters and accelerated by hubs but was also affected by small-population mechanisms prevalent for invasions, such as Allee effects. Read More

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December 2018

Oscillatory dynamics of cortical functional connections in semantic prediction.

Hum Brain Mapp 2018 Dec 7. Epub 2018 Dec 7.

MEG and Cortical Networks Group, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany.

An event related potential, known as the N400, has been particularly useful in investigating language processing as it serves as a neural index for semantic prediction. There are numerous studies on the functional segregation of N400 neural sources; however, the oscillatory dynamics of functional connections among the relevant sources has remained elusive. In this study we acquired magnetoencephalography data during a classic N400 paradigm, where the semantic predictability of a fixed target noun was manipulated in simple German sentences. Read More

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December 2018

Astrocytic insulin-like growth factor-1 prevents excitotoxic downregulation of adenosine deaminase acting on RNA in calcium dynamics.

J Cell Biochem 2018 Dec 9. Epub 2018 Dec 9.

Department of Neurosurgery, Shanghai Pudong New Area People's Hospital Shanghai, China.

Background: A-to-I RNA editing catalyzed by the adenosine deaminase acting on RNA (ADAR) 1 represents an RNA-based recoding mechanism implicated in a variety of cellular processes like intracellular homeostasis. Previous studies have demonstrated that the expression of ADAR1 is increased in glioma, and ADAR1 short hairpin RNA affects regulated cellular exocytosis. This indicates that ADAR1 might be involved in cellular proliferation and/or apoptosis. Read More

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December 2018

The importance and adaptive value of life-history evolution for metapopulation dynamics.

J Anim Ecol 2018 Nov 22. Epub 2018 Nov 22.

Department of Biology, Research Group Phycology - Bioinformatics & Evolutionary Genomics, Ghent University, Ghent, Belgium.

The spatial configuration and size of patches influence metapopulation dynamics by altering colonisation-extinction dynamics and local density dependency. This spatial forcing as determined by the metapopulation typology then imposes strong selection pressures on life-history traits, which will in turn feed back on the ecological metapopulation dynamics. Given the relevance of metapopulation persistence for biological conservation, and the potential rescuing role of evolution, a firm understanding of the relevance of these eco-evolutionary processes is essential. Read More

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November 2018
2 Reads

Microtubules: From understanding their dynamics to using them as potential therapeutic targets.

Authors:
Yaron Ilan

J Cell Physiol 2018 Dec 10. Epub 2018 Dec 10.

Department of Medicine, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.

Microtubules (MT) and actin microfilaments are dynamic cytoskeleton components involved in a range of intracellular processes. MTs play a role in cell division, beating of cilia and flagella, and intracellular transport. Over the past decades, much knowledge has been gained regarding MT function and structure, and its role in underlying disease progression. Read More

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December 2018
1 Read

Contrasting stomatal sensitivity to temperature and soil drought in mature alpine conifers.

Plant Cell Environ 2018 Dec 10. Epub 2018 Dec 10.

Swiss Federal Research Institute for Forest, Snow and Landscape Research (WSL), Zürcherstrasse 111, CH-8903, Birmensdorf, Switzerland.

We used four years of sap flow measurements to elucidate intra- and inter-specific variability of g in Larix decidua Mill. and Picea abies (L.) Karst along an elevational gradient and contrasting soil moisture conditions. Read More

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December 2018

Unexpected bird-feather mite associations revealed by DNA metabarcoding uncovers a dynamic ecoevolutionary scenario.

Mol Ecol 2018 Dec 10. Epub 2018 Dec 10.

Department of Evolutionary Ecology, Estación Biológica de Doñana (EBD-CSIC), Avda. Americo Vespucio 26, Sevilla, 41092, Spain.

The high relevance of host-switching for the diversification of highly host-specific symbionts (i.e., those commonly inhabiting a single host species) demands a better understanding of host-switching dynamics at an ecological scale. Read More

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December 2018

Substituent Effect on Metastable-State Photoacids: Design, Synthesis and Evaluation of their Photochemical Properties.

Chem Asian J 2018 Dec 7. Epub 2018 Dec 7.

UNITED STATES.

Recently, metastable-state photoacids have been widely used to control proton transfer in numerous chemical and biological processes as well as applications with visible light. Generally, substituent groups have great influence on photochemical properties of molecules, which will further affect their applications. Yet, substituent effect on the metastable-state photoacid has not been studied systematically. Read More

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December 2018

An In Silico approach to discover the best molecular modelling strategy for designing novel CDK4 inhibitors.

Chem Biol Drug Des 2018 Dec 8. Epub 2018 Dec 8.

Department of Chemistry, Sree Narayana College, Kollam, Kerala, India, 691001.

Designing of new potential specific inhibitors for CDK4 is very important in cancer therapy. The imperative features that can inhibit CDK4 were identified and refined by docking under standard precision mode, extra precision mode, extra precision mode with core-constraints and induced fit using extra precision protocol. Statistically significant correlation was observed when docking experiments in the extra precision mode carried out by applying core constraints in the ligand molecule which forms two specific hydrogen bonds with Val96 of CDK4. Read More

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December 2018

Label-Free Metabolic Classification of Single Cells in Droplets Using the Phasor Approach to Fluorescence Lifetime Imaging Microscopy.

Cytometry A 2018 Dec 11. Epub 2018 Dec 11.

Biomedical Engineering Department, University of California, Irvine, California.

Characterization of single cell metabolism is imperative for understanding subcellular functional and biochemical changes associated with healthy tissue development and the progression of numerous diseases. However, single-cell analysis often requires the use of fluorescent tags and cell lysis followed by genomic profiling to identify the cellular heterogeneity. Identifying individual cells in a noninvasive and label-free manner is crucial for the detection of energy metabolism which will discriminate cell types and most importantly critical for maintaining cell viability for further analysis. Read More

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December 2018

Bottom-up trait-mediated indirect effects decrease pathogen transmission in a tritrophic system.

Authors:
Bret D Elderd

Ecology 2018 Dec 11. Epub 2018 Dec 11.

Department of Biological Sciences, Louisiana State University, Baton Rouge, Louisiana, 70803, USA.

A plant's induction of secondary defenses helps to decrease herbivore damage by changing resource quality. While these chemical or physical defenses may directly decrease herbivory, they can also have indirect consequences. In a tritrophic system consisting of a plant, an insect herbivore, and an insect pathogen, plant based trait-mediated indirect effects (TMIEs) can alter host-pathogen interactions and, thereby, indirectly affect disease transmission. Read More

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December 2018

The diversity of population responses to environmental change.

Ecol Lett 2018 Dec 9. Epub 2018 Dec 9.

Université Lyon 1, CNRS, UMR 5558, Laboratoire de Biométrie et Biologie Evolutive, F-69622, Villeurbanne, France.

The current extinction and climate change crises pressure us to predict population dynamics with ever-greater accuracy. Although predictions rest on the well-advanced theory of age-structured populations, two key issues remain poorly explored. Specifically, how the age-dependency in demographic rates and the year-to-year interactions between survival and fecundity affect stochastic population growth rates. Read More

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December 2018

Regulation of G protein-coupled receptor signaling by plasma membrane organization and endocytosis.

Traffic 2018 Dec 7. Epub 2018 Dec 7.

Department of Pharmacology, The University of Michigan Medical School, Ann Arbor, MI.

The trafficking of G protein coupled-receptors (GPCRs) is one of the most exciting areas in cell biology due to recent advances demonstrating that GPCR signaling is spatially encoded. GPCRs, acting in a diverse array of physiological systems, can have differential signaling consequences depending on their subcellular localization. At the plasma membrane, GPCR organization could fine-tune the initial stages of receptor signaling by determining the magnitude of signaling and the type of effectors to which receptors can couple. Read More

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December 2018

T-705-modified ssRNA in complex with Lassa Virus Nucleoprotein exhibits nucleotide splaying and increased water influx into the RNA-binding pocket.

Chem Biol Drug Des 2018 Dec 10. Epub 2018 Dec 10.

Center for Biocumputing and Drug Development, Adekunle Ajasin University, Akungba-Akoko, Ondo State, Nigeria.

Lassa virus infection is clinically characterized by multi-organ failure in humans. Without an FDA-approved vaccine, ribavirin is the frontline drug for treatment but with attendant toxicities. 6-fluoro-3-hydroxy-2-pyrazinecarboxamide (T-705) is an emerging alternative drug with proven anti-Lassa virus activity in experimental model. Read More

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December 2018

Removal Efficacy of Opportunistic Pathogens and Bacterial Community Dynamics in Two Drinking Water Treatment Trains.

Small 2018 Dec 7:e1804436. Epub 2018 Dec 7.

Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University, Shanghai, 200433, China.

Drinking water treatment processes (DWTPs) impact pathogen colonization and microbial communities in finished water; however, their efficacies against opportunistic pathogens are not fully understood. In this study, the effects of treatment steps on the removal of Legionella spp., Legionella pneumophila, nontuberculous mycobacteria, Mycobacterium avium, and two amoeba hosts (Vermamoeba vermiformis, Acanthamoeba) are evaluated in two parallel trains of DWTPs equipped with different pretreatment units. Read More

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December 2018

Population collapse and adaptive rescue during long-term chemostat fermentation.

Biotechnol Bioeng 2018 Dec 8. Epub 2018 Dec 8.

UC Davis Genome Center, University of California-Davis.

Microbial fermentation is an essential process for research and industrial applications, yet our understanding of cellular dynamics during long-term fermentation is limited. Here, we report a reproducible phenomenon of abrupt population collapse followed by a rapid population rescue that was observed during long-term chemostat cultivations, for various strains of Escherichia coli and under minimal media. Through genome resequencing and whole-genome transcriptional profiling of replicate runs over time, we identified that changes in the tRNA and carbon catabolic genes is the genetic basis of this phenomenon. Read More

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December 2018

Mitochondrial Neuroglobin Is Necessary for Protection Induced by Conditioned Medium from Human Adipose-Derived Mesenchymal Stem Cells in Astrocytic Cells Subjected to Scratch and Metabolic Injury.

Mol Neurobiol 2018 Dec 8. Epub 2018 Dec 8.

Departamento de Nutrición y Bioquímica, Facultad de Ciencias, Pontificia Universidad Javeriana, Bogotá, D.C., Colombia.

Astrocytes are specialized cells capable of regulating inflammatory responses in neurodegenerative diseases or traumatic brain injury. In addition to playing an important role in neuroinflammation, these cells regulate essential functions for the preservation of brain tissue. Therefore, the search for therapeutic alternatives to preserve these cells and maintain their functions contributes in some way to counteract the progress of the injury and maintain neuronal survival in various brain pathologies. Read More

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December 2018

Modeling the Transmission Dynamics of Rabies for Dog, Chinese Ferret Badger and Human Interactions in Zhejiang Province, China.

Bull Math Biol 2018 Dec 10. Epub 2018 Dec 10.

School of Mathematics and Statistics, Central China Normal University, Wuhan, 430079, People's Republic of China.

Human rabies is one of the major public health problems in China with an average of 1977 cases per year. It is estimated that 95% of these human rabies cases are due to dog bites. In recent years, the number of wildlife-associated human rabies cases has increased, particularly in the southeast and northeast regions of mainland China. Read More

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December 2018

The "Memory" Effect in a Chain of Biochemical Reactions with a Positive Feedback is Enhanced by Substrate Saturation Described by Michaelis-Menten Kinetics.

Bull Math Biol 2018 Dec 10. Epub 2018 Dec 10.

Institute of Biosciences, Life Sciences Center, Vilnius University, Sauletekio Ave 7, 10257, Vilnius, Lithuania.

Information in the brain is stored in a form of an altered synaptic strength between neurons. The long-term potentiation (LTP), a phenomenon when a short-term increase in neural activity is transformed into a long-lasting increase in strengths of synaptic connectivity, provides an experimental substrate of memory. Using reaction-diffusion equations, we established an LTP model, describing the dynamics of glutamate (Glu), calcium (Ca) and nitric oxide (NO) in response to the stimulus-a presynaptic action potential. Read More

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December 2018

Comparative Analysis of Anuran Amphibian Skin Microbiomes Across Inland and Coastal Wetlands.

Microb Ecol 2018 Dec 8. Epub 2018 Dec 8.

Department of Biology, East Carolina University, Greenville, NC, USA.

Amphibians host a community of microbes on their skin that helps resist infectious disease via the dual influence of anti-pathogenic microbial species and emergent community dynamics. Many frogs rely on freshwater habitats, but salinization is rapidly increasing saltwater concentrations in wetlands around the globe, increasing the likelihood that frogs will come into contact with salt-contaminated habitats. Currently, we know little about how increased salt exposure will affect the symbiotic relationship between the skin microbes and frog hosts. Read More

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December 2018
1 Read

Oligomeric transition and dynamics of RNA binding by the HuR RRM1 domain in solution.

J Biomol NMR 2018 Dec 8. Epub 2018 Dec 8.

Department of Biochemistry, Institute of Chemistry, Federal University of Rio de Janeiro, Rio de Janeiro, 21941-909, Brazil.

Human antigen R (HuR) functions as a major post-transcriptional regulator of gene expression through its RNA-binding activity. HuR is composed by three RNA recognition motifs, namely RRM1, RRM2, and RRM3. The two N-terminal RRM domains are disposed in tandem and contribute mostly to HuR interaction with adenine and uracil-rich elements (ARE) in mRNA. Read More

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December 2018
1 Read

Range Expansion Theories Could Shed Light on the Spatial Structure of Intra-tumour Heterogeneity.

Bull Math Biol 2018 Dec 7. Epub 2018 Dec 7.

Interfaculty Bioinformatics Unit, University of Bern, 3012, Bern, Switzerland.

Many theoretical studies of range expansions focus on the dynamics of species' ranges or on causes and consequences of biological invasions. The similarities between biological range expansions and the dynamics of tumour growth have recently become more obvious, highlighting that tumours can be viewed as a population of abnormal cells expanding its range in the body of its host. Here, we discuss the potential of recent theoretical developments in the context of range expansions to shed light on intra-tumour heterogeneity, and to develop novel computational and statistical methods for studying the increasingly available genomic and phenotypic data from tumour cells. Read More

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December 2018

Competent Hosts and Endemicity of Multi-Host Vector-Borne Diseases.

Bull Math Biol 2018 Dec 7. Epub 2018 Dec 7.

Universidad de los Andes, Bogotá, Colombia.

In this paper, we propose a method to study a general vector-host mathematical model in order to explain how the changes in biodiversity could influence the dynamics of vector-borne diseases. We find that under the assumption of frequency-dependent transmission, i.e. Read More

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December 2018

Mitochondrial membrane transporters and metabolic switch in heart failure.

Heart Fail Rev 2018 Dec 10. Epub 2018 Dec 10.

Cardiovascular Diseases and Diabetes Biology group, Rajiv Gandhi Centre for Biotechnology (RGCB), Poojappura, Thycaud Post, Trivandrum, Kerala, 695014, India.

Mitochondrial dysfunction is widely recognized as a major factor for the progression of cardiac failure. Mitochondrial uptake of metabolic substrates and their utilization for ATP synthesis, electron transport chain activity, reactive oxygen species levels, ion homeostasis, mitochondrial biogenesis, and dynamics as well as levels of reactive oxygen species in the mitochondria are key factors which regulate mitochondrial function in the normal heart. Alterations in these functions contribute to adverse outcomes in heart failure. Read More

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December 2018

Repair characteristics and time-dependent effects in Saccharomyces cerevisiae cells after X-ray irradiation.

World J Microbiol Biotechnol 2018 Dec 10;35(1). Epub 2018 Dec 10.

Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou, 730000, China.

In this study, we examined the dynamics of phenotypic and transcriptional profiles in Saccharomyces cerevisiae following semi-lethal X-ray irradiation. Post-irradiation, reproductive death was revealed as the predominant form of death in S. cerevisiae and almost all the irradiated cells were physically present and intact. Read More

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December 2018

Disease-specific characteristics of vascular cell adhesion molecule-1 levels in patients with peripheral artery disease.

Heart Vessels 2018 Dec 7. Epub 2018 Dec 7.

Department of Internal Medicine I, Friedrich Schiller University Jena, Jena, Germany.

Peripheral arterial disease (PAD) is one of the most common manifestations of systemic atherosclerosis. The prevalence of unrecognized PAD is high, leading to a lack of opportunity to detect subjects at a high risk for cardiovascular events. Inflammatory processes play an important role in the disease initiation as well as in the disease progression. Read More

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December 2018
1 Read

An updated perspective on spiders as generalist predators in biological control.

Oecologia 2018 Dec 8. Epub 2018 Dec 8.

Institute for Environmental Sciences, University of Koblenz-Landau, Fortstrasse 7, 76829, Landau/Pfalz, Germany.

The role of generalist predators in biological control remains controversial as they may not only reduce pest populations but also disrupt biocontrol exerted by other natural enemies. Here, we focus on spiders as a model group of generalist predators. They are among the most abundant and most diverse natural enemies in agroecosystems. Read More

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December 2018

Stepfamily Structure and Transfers Between Generations in U.S. Families.

Demography 2018 Dec 7. Epub 2018 Dec 7.

California Center for Population Research and Department of Sociology, University of California, Los Angeles, CA, 90095, USA.

Unstable couple relationships and high rates of repartnering have increased the share of U.S. families with stepkin. Read More

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December 2018
1 Read

Selection criteria for linear regression models to estimate individual tree biomasses in the Atlantic Rain Forest, Brazil.

Carbon Balance Manag 2018 Dec 7;13(1):25. Epub 2018 Dec 7.

Graduate Programme in Forestry, Federal University of Paraná, Curitiba, Brazil.

Background: Biomass models are useful for several purposes, especially for quantifying carbon stocks and dynamics in forests. Selecting appropriate equations from a fitted model is a process which can involves several criteria, some widely used and others used to a lesser extent. This study analyzes six selection criteria for models fitted to six sets of individual biomass collected from woody indigenous species of the Tropical Atlantic Rain Forest in Brazil. Read More

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December 2018
1 Read

Mitochondrial Bioenergetics and Dynamics During Infection.

Exp Suppl 2018 ;109:221-233

CNRS FR3636, Faculty of Medecine des Saint-Pères, Paris Descartes University, Paris, France.

Microbes have developed a series of strategies to overcome the defense mechanisms of the infected host. During pathogen-host coevolution, they develop strategy to manipulate cellular machinery particularly in subverting mitochondrion function. Mitochondria are highly dynamic organelles that constantly remodel their structure. Read More

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January 2018

Eosinophilia in pediatric uncomplicated appendicitis is a time stable pattern.

Pediatr Surg Int 2018 Dec 7. Epub 2018 Dec 7.

Department of Pediatric Surgery, Charité, Universitätsmedizin Berlin, Augustenburger Platz 1, 13353, Berlin, Germany.

Purpose: We have recently shown that uncomplicated phlegmonous appendicitis is characterized by independent inflammatory patterns based on significant eosinophilia in children aged 7-17 years. However, clinical decision-making based on inflammatory values is not easy, especially due to the dynamics of inflammation over time. The present study was performed to evaluate the basic distinguishability of the inflammatory entities by laboratory values over time based on an extended patient number with children aged 0-17 years. Read More

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December 2018

Novel surgical strategy for complicated pulmonary stenosis using haemodynamic analysis based on a virtual operation with numerical flow analysis.

Interact Cardiovasc Thorac Surg 2018 Dec 6. Epub 2018 Dec 6.

Department of Cardiovascular Surgery, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan.

Objectives: A novel surgical strategy using haemodynamic analyses based on virtual operations with computational simulations has been introduced for complicated pulmonary stenosis. We evaluated the efficacy of this strategy.

Methods: Six patients were enrolled. Read More

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December 2018

Referral of patients for fractional flow reserve using quantitative flow ratio.

Eur Heart J Cardiovasc Imaging 2018 Dec 11. Epub 2018 Dec 11.

Department of Cardiology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands.

Aims: Quantitative flow ratio (QFR) is a recently developed technique to calculate fractional flow reserve (FFR) based on 3D quantitative coronary angiography and computational fluid dynamics, obviating the need for a pressure-wire and hyperaemia induction. QFR might be used to guide patient selection for FFR and subsequent percutaneous coronary intervention (PCI) referral in hospitals not capable to perform FFR and PCI. We aimed to investigate the feasibility to use QFR to appropriately select patients for FFR referral. Read More

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December 2018

Oxytocin Modulates the Intrinsic Dynamics Between Attention-Related Large-Scale Networks.

Cereb Cortex 2018 Dec 7. Epub 2018 Dec 7.

The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Laboratory for Neuroinformation, University of Electronic Science and Technology of China, Chengdu, China.

Attention And Salience Processing Have Been Linked To The Intrinsic Between- And Within-network Dynamics Of Large-scale Networks Engaged In Internal (default Network [dn]) And External Attention Allocation (dorsal Attention Network [dan] And Salience Network [sn]). The Central Oxytocin (oxt) System Appears Ideally Organized To Modulate Widely Distributed Neural Systems And To Regulate The Switch Between Internal Attention And Salient Stimuli In The Environment. The Current Randomized Placebo (plc)-controlled Between-subject Pharmacological Resting-state Fmri Study In N = 187 (oxt, N = 94; Plc, N = 93; Single-dose Intranasal Administration) Healthy Male And Female Participants Employed An Independent Component Analysis Approach To Determine The Modulatory Effects Of Oxt On The Within- And Between-network Dynamics Of The Dan–sn–dn Triple Network System. Read More

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December 2018