Search Our Scientific Publications & Authors

Bone Joint J 2021 May;103-B(5):946-950

Department of Trauma and Orthopaedic Surgery, St Mary's Hospital, London, UK.

Aims: The results of surgery for Dupuytren's disease can be compromised by the potential for disease recurrence and loss of function. Selecting which patients will benefit from repeat surgery, when to operate, and what procedure to undertake requires judgement and an understanding of patient expectations and functional needs. We undertook this study to investigate patient outcomes and satisfaction following repeat limited fasciectomy for recurrent Dupuytren's disease. Read More

J Hand Surg Asian Pac Vol 2021 Jun;26(2):131-141

Department of Orthopaedic Surgery, Dongguk University Ilsan Hospital, Goyang, Korea.

Dupuytren disease (DD) is a fibroproliferative disorder that originates at the palmar fascia and results in flexion contracture of the digits. The gold standard treatment for DD has been surgery. Surgical treatment of DD can be done with various methods, from percutaneous needle fasciotomy to dermatofasciectomy. Read More

J Orthop Res 2021 Apr 29. Epub 2021 Apr 29.

Department of Orthopaedic Surgery, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.

Dupuytren's disease is a benign fibroproliferative disorder of the hand that results in disabling digital contractures that impair function and diminish the quality of life. The incidence of this disease has been correlated with chronic inflammatory states, but any direct association between inflammatory cytokines and Dupuytren's disease is not known. We hypothesized that advanced fibroproliferation is associated with increased levels of circulating inflammatory cytokines. Read More

Hand (N Y) 2021 Apr 15:15589447211006834. Epub 2021 Apr 15.

University Hospitals of Leicester, UK.

Background: Clinical goniometry for the assessment of contracture in Dupuytren disease is time-consuming and costly, and there is no universal method for evaluating the severity of the disease. This study aims to evaluate the feasibility of patient-taken photography for the remote assessment of Dupuytren disease.

Methods: Patients at our unit were provided with instructions on how to take standardized photographs of their diseased hand(s), which were subsequently analyzed by computer software to obtain formal measurements of the severity of disease. Read More

Hand Surg Rehabil 2021 Mar 30. Epub 2021 Mar 30.

Department of Orthopedic Surgery, UZ Leuven, Herestraat 49, Leuven, Belgium.

Full thickness grafting can be considered after fasciectomy for Dupuytren contracture in severe cases with skin shortage or in radical dermofasciectomy. It is a common dogma that these skin grafts may prevent disease recurrence. We reviewed 47 patients after fasciectomy and full-thickness skin grafting for Dupuytren contracture at 3-16 years' follow-up. Read More

Bone Joint J 2021 Apr;103-B(4):704-710

Department of Plastic Surgery, University Medical Center Groningen, Groningen, the Netherlands.

Aims: With novel promising therapies potentially limiting progression of Dupuytren's disease (DD), better patient stratification is needed. We aimed to quantify DD development and progression after seven years in a population-based cohort, and to identify factors predictive of disease development or progression.

Methods: All surviving participants from our previous prevalence study were invited to participate in the current prospective cohort study. Read More

Arch Bone Jt Surg 2021 Jan;9(1):85-92

Department of Surgery and Perioperative Care, Dell Medical School, The University of Texas at Austin, Austin, TX, USA.

Background: There is a growing interest in engaging patients in research priorities and project design. This study compared topics patients and surgeons would like to address in upper extremity musculoskeletal research.

Methods: We invited patients on social media-based support groups for specific musculoskeletal illnesses and members of the Science Of Variation Group to indicate the three most important research topics by disease. Read More

Clinicoecon Outcomes Res 2021 15;13:163. Epub 2021 Mar 15.

[This corrects the article DOI: 10.2147/CEOR.S269957. Read More

J Hand Surg Am 2021 May 17;46(5):403-408. Epub 2021 Mar 17.

Queen Margaret Hospital, Dunfermline, United Kingdom.

Purpose: To describe patients' self-reported hand normality before and after surgery for Dupuytren contracture and to determine whether this metric could be used as an adjunct to determine the success of surgery.

Methods: Preoperative and 1-year postoperative Quick-Disabilities of the Arm, Shoulder, and Hand and EuroQol 5-Dimensions 5-level scores were collected prospectively over 5 years. Patients were asked "How normal is your hand?" Scores were recorded on a 100-point visual analog scale. Read More

Hand (N Y) 2021 Feb 22:1558944721994220. Epub 2021 Feb 22.

McMaster University, Hamilton, ON, Canada.

Background: With numerous treatment modalities available, it is unclear whether the treatment of recurrent Dupuytren disease is as effective as its initial treatment. We aimed to investigate the outcomes of management of recurrent Dupuytren contracture.

Methods: Adhering to Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, MEDLINE, Embase, PubMed, CINAHL, and Cochrane Central Register of Controlled Trials were searched from their inception to April 2020. Read More

Ann Plast Surg 2021 Feb 12. Epub 2021 Feb 12.

From the Department of Orthopaedic Surgery, University of Pennsylvania, Philadelphia, PA Research Department, Shriners Hospitals for Children, Cincinnati, OH Department of Pathology and Laboratory Medicine, University of Cincinnati College of Medicine, Cincinnati, OH.

Abstract: Dupuytren disease is a connective tissue disorder occurring on the palm, causing flexion contractures of fingers. There is a pressing need for therapeutic interventions that can slow, stop, or even incrementally reverse the progression of the disease. Numerous in vitro studies have shed light on cellular and molecular agents that contribute to contractures. Read More

J Hand Surg Am 2021 Feb 9. Epub 2021 Feb 9.

The Curtis National Hand Center, Baltimore. Electronic address:

Purpose: We evaluated the concurrent validity of the Patient-Reported Outcomes Measurement Information System (PROMIS) Global Mental Health (GMH), Global Physical Health (GPH), Upper Extremity (UE), Pain Interference (PI), and Self-Efficacy for Managing Medications and Treatment (SE-MMT) by analyzing correlation to the brief Michigan Hand Questionnaire (bMHQ) in patients with 5 common hand conditions: carpal tunnel syndrome, Dupuytren contracture, trigger finger, thumb carpometacarpal osteoarthritis, and wrist ganglion cysts.

Methods: Our cohort included 11,782 unique visits representing 4,401 patients. Patient demographics, PROMIS Computer Adaptive Test questionnaires, and bMHQ were collected prospectively at all visits for all patients. Read More

Hand (N Y) 2021 Jan 21:1558944720974119. Epub 2021 Jan 21.

William Beaumont Army Medical Center, El Paso, TX, USA.

This systematic review investigates complications and recurrence of Dupuytren's contracture in metacarpophalangeal joints (MCPJs) and/or proximal interphalangeal joints (PIPJs) of fingers treated with collagenase clostridium histolyticum (CCH). A review of the literature on Dupuytren's disease was performed using PRISMA guidelines. Included publications described complications and/or recurrences for contractures ≥20° in MCPJs and/or PIPJs treated with CCH. Read More

J Plast Reconstr Aesthet Surg 2021 03 24;74(3):644-710. Epub 2020 Dec 24.

Centre Hospitalier Interregional Edith Cavell, Bruxelles, Belgium. Electronic address:

J Plast Reconstr Aesthet Surg 2020 Dec 5. Epub 2020 Dec 5.

Pharmacy Program. University of Granada. Faculty of Pharmacy. 18011, Granada. Spain.

Background: In health care, quality-of-life surveys and questionnaires related to care are becoming increasingly important as a measure of its quality. There is currently no Spanish version of the Unité Rhumatologique des Affections de la Main (URAM) scale, which makes it suitable for hand pathology. The purposes of this study are to develop a Spanish version of the URAM and perform a transcultural adaptation of it, analyzing the result for reliability, validity, and sensitivity to changes. Read More

JPRAS Open 2021 Mar 30;27:80-89. Epub 2020 Nov 30.

Department of Plastic & Reconstructive Surgery, Royal Devon & Exeter Hospital NHS Foundation Trust, Devon, EX2 5DW, UK.

Background: Percutaneous needle fasciotomy (PNF) represents the only minimally invasive approach for treatment of Dupuytren's disease in Europe since withdrawal of collagenase from European markets. Though well-established, surgeon preference and uncertainty regarding safety and efficacy, results in limited provision in favour of open fasciectomy.

Methods: A retrospective review of 74 patients who self-opted to receive PNF between 2017 and 2020 was conducted. Read More

J Biol Regul Homeost Agents 2020 Jul-Aug;34(4 Suppl. 3):279-284. Congress of the Italian Orthopaedic Research Society

Istituto di Clinica Ortopedica, Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma, Italia.

Dupuytren Disease is a benign fibromatosis of palmar fascia of the hand, whose pathophysiology is not completely understood. The present study is intended to provide a description of the effects of Collagenase of Clostridium Hystoliticum (CCH) into an injected cord of Dupuytren. Our experimental study wanted to evaluate the histological effects of injection of CCH in the first 24 hours, without manipulating the specimens. Read More

Clinicoecon Outcomes Res 2020 4;12:635-643. Epub 2020 Nov 4.

Medical Affairs, Endo Pharmaceuticals Inc., Malvern, PA, USA.

Objective: Studies examining differences in US healthcare resource utilization (HCRU) and associated healthcare costs between collagenase clostridium histolyticum (CCH) and fasciectomy for Dupuytren contracture (DC) are limited. This study evaluated US HCRU and direct healthcare cost for the treatment of DC in privately insured patients using insurance claims.

Methods: This retrospective observational cohort study analyzed data from large nationwide insurance claims databases; it included individuals diagnosed with DC between July 1, 2011, and June 30, 2017, who were adults at index date (date of first treatment: CCH or fasciectomy). Read More

Plast Reconstr Surg 2020 11;146(5):1080-1081

From MetroHealth Medical Center.

Plast Reconstr Surg 2020 11;146(5):1071-1079

From the Department of Orthopaedic Surgery, Brigham and Women's Hospital; and Harvard Medical School.

Background: The objective of this study was to determine the rates of patient satisfaction, perceived recurrence of flexion deformity, and additional treatment after collagenase clostridium histolyticum treatment for Dupuytren's contracture at a minimum of 5-year follow-up.

Methods: A retrospective study was performed of 199 digits in 142 patients who underwent collagenase clostridium histolyticum treatments from April of 2010 to December of 2013 with a minimum of 5-year follow-up. Patients were contacted by telephone regarding perceived recurrence, additional treatment, satisfaction, and willingness to undergo this treatment again. Read More

J Orthop Surg Res 2020 Oct 28;15(1):495. Epub 2020 Oct 28.

School of Computing, Electronics and Maths, Coventry University, London, UK.

Background: The Dupuytren disease is a benign fibroproliferative disorder that leads to the formation of the collagen knots and fibres in the palmar fascia. The previous studies reveal different levels of Dupuytren's prevalence worldwide; hence, this study uses meta-analysis to approximate the prevalence of Dupuytren globally.

Methods: In this study, systematic review and meta-analysis have been conducted on the previous studies focused on the prevalence of the Dupuytren disease. Read More

J Hand Surg Asian Pac Vol 2020 Dec;25(4):453-461

Department of Plastic, Reconstructive and Hand Surgery, Peninsula Health, Frankston, VIC, Australia.

Management of Dupuytren Disease is variable, and influenced by multiple factors including location, extent of disease, surgical preference and familiarity with different treatment techniques. The objective of this study was to determine current Dupuytren Disease management trends in Australia. A questionnaire was sent through The Australian Hand Surgery Society to all members. Read More

J Hand Surg Asian Pac Vol 2020 Dec;25(4):513-514

Department of Plastic, Reconstructive, Aesthetic and Hand Surgery, University Hospital Basel, Basel, Switzerland.

We present the case of a severe and long-standing Dupuytren's contracture where intraoperatively an ossified nodule was encountered within the diseased tissue. Histologically palmar fibromatosis in contact with cartilaginous tissue with central ossification could be confirmed, compatible with metaplasia. Our finding suggests that metaplastic activity inherent to longstanding, severely diseased Dupuytren's tissue can lead to heterotopic ossification. Read More

Hand (N Y) 2020 Oct 20:1558944720963915. Epub 2020 Oct 20.

Stanford University, Palo Alto, CA, USA.

Background: One of the most feared complications following treatment of Dupuytren contracture is complex regional pain syndrome (CRPS). This study aims to provide a national perspective on the incidence of CRPS following treatment of Dupuytren contracture and identify patient factors to target for risk reduction.

Methods: Using the Truven MarketScan databases from 2007 to 2016, individuals aged ≥18 years who developed CRPS within 1 year of treatment of Dupuytren contracture were identified using the International Classification of Disease diagnosis code for CRPS. Read More

J Plast Surg Hand Surg 2021 Feb 12;55(1):32-40. Epub 2020 Oct 12.

Twin Cities Orthopaedics, Edina, MN, USA.

Purpose: Dupuytren disease (DD) has been associated with enlarged Pacinian corpuscles (PCs) and with PCs having a greater number of lamellae. Based on these associations, we hypothesized that subjects with DD would have altered sensitivity to high-frequency vibrations and that the changes would be more prominent at 250 Hz, where healthy subjects demonstrate the highest sensitivity.

Methods: A novel device was created to deliver vibrations of specific frequencies and amplitudes to the fingers and palm. Read More

JAMA Netw Open 2020 10 1;3(10):e2019861. Epub 2020 Oct 1.

Section of Plastic Surgery, Department of Surgery, University of Michigan Medical School, Ann Arbor.

Importance: Owing to its tendency to recur, Dupuytren contracture often requires multiple treatments, which places additional economic burden on health care. The likelihood of contracture recurrence varies not only with treatment but also with disease characteristics, such as contracture severity and location, but prior cost-effectiveness analyses of Dupuytren contracture treatments have not considered these patient-specific disease characteristics.

Objective: To identify the most cost-effective treatment regimen for patients with recurrent Dupuytren contracture. Read More

Sci Rep 2020 10 5;10(1):16520. Epub 2020 Oct 5.

Oxford NIHR Musculoskeletal Biomedical Research Unit, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Nuffield Orthopaedic Centre, Botnar Research Centre, University of Oxford, Windmill Road, Oxford, OX3 7LD, UK.

Dupuytren's disease (DD) is a common fibro-proliferative disorder of the palm. We estimated the risk of serious local and systemic complications and re-operation after DD surgery. We queried England's Hospital Episode Statistics database and included all adult DD patients who were surgically treated. Read More

Bone Joint J 2020 Oct;102-B(10):1354-1358

Gateshead NHS Foundation Trust, Gateshead, UK.

Aims: In the UK, fasciectomy for Dupuytren's contracture is generally performed under general or regional anaesthetic, with an arm tourniquet and in a hospital setting. We have changed our practice to use local anaesthetic with adrenaline, no arm tourniquet, and perform the surgery in a community setting. We present the outcome of a consecutive series of 30 patients. Read More

Plast Reconstr Surg 2020 10;146(4):799-807

From the Nuffield Department of Orthopaedics, Rheumatology, and Musculoskeletal Sciences, University of Oxford, Botnar Research Centre; and the Salisbury District Hospital.

Background: Dupuytren's disease is a common complex disease caused by genetic and nongenetic factors. The role of many nongenetic risk factors is still unclear and debatable. This study aimed to systematically review the association between Dupuytren's disease and nongenetic risk factors. Read More