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    The Use of Residual Collagenase for Single Digits With Multiple-Joint Dupuytren Contractures.
    J Hand Surg Am 2017 Apr 4. Epub 2017 Apr 4.
    Department of Orthopaedic Surgery, Geisinger Medical Center, Danville, PA.
    Purpose: Standard 0.58 mg (0.25 mL) collagenase Clostridium histolyticum (CCH) preparations result in unused CCH that is often discarded. Read More

    Treatment of Recurrent Dupuytren Contracture in Joints Previously Effectively Treated With Collagenase Clostridium histolyticum.
    J Hand Surg Am 2017 Mar 21. Epub 2017 Mar 21.
    Endo Pharmaceuticals Inc., Malvern, PA.
    Purpose: Collagenase Clostridium histolyticum (CCH) is approved for the treatment of adults with Dupuytren contracture with a palpable cord. This open-label, phase 4 study evaluated the safety and efficacy of CCH for the retreatment of recurrent contractures in joints that were previously effectively treated with CCH.

    Methods: Patients participating in a long-term follow-up study who had contracture recurrence (increased ≥ 20° with a palpable cord) after successful treatment in the previous study were eligible. Read More

    Collagenase injections for Dupuytren's disease: prospective cohort study assessing 2-year treatment effect durability.
    BMJ Open 2017 Mar 15;7(3):e012943. Epub 2017 Mar 15.
    Department of Orthopedics, Hässleholm-Kristianstad-Ystad Hospitals, Hässleholm, Sweden.
    Objectives: To assess 2-year durability of joint contracture correction following collagenase injections for Dupuytren's disease.

    Design: Prospective cohort study.

    Setting: Orthopaedic Department in Sweden. Read More

    Modified McCash Technique for Management of Dupuytren Contracture.
    J Hand Surg Am 2017 Mar 1. Epub 2017 Mar 1.
    Hand and Upper Extremity Center, Wexford, PA.
    Despite recent advancements in the nonsurgical treatment for Dupuytren contracture, a number of patients remain poor nonsurgical candidates or elect for surgical management. The traditional McCash technique releases contractures while leaving open palmar wounds. Although successful in alleviating contractures, these wounds are traditionally large, transverse incisions across the palm. Read More

    [Primary intervention in Dupuytren's disease].
    Orthopade 2017 Apr;46(4):336-341
    Abteilung für Plastische-, Hand- und Rekonstruktive Chirurgie, BG-Unfallklinik Frankfurt am Main, Friedberger Landstraße 430, 60389, Frankfurt am Main, Deutschland.
    Partial aponeurectomy as the state-of-the-art treatment in Dupuytren's disease is indicated when minimally invasive forms of treatment, such as needle aponeurotomy or percutaneous collagenase injection, are not possible due to the advanced stage of the disease or the morphology of the contracture. Even in earlier stages of Dupuytren disease partial aponeurectomy has advantages in comparison to minimally invasive forms of treatment. These advantages are lower recurrence rates as well as less persistent residual contractures, especially in the proximal interphalangeal joint. Read More

    A clinical trial of tension and compression orthoses for Dupuytren contractures.
    J Hand Ther 2017 Feb 21. Epub 2017 Feb 21.
    Orthopaedic Department, Hand Unit, University Hospitals Leuven, Pellenberg Campus, Pellenberg, Belgium.
    Study Design: Randomized clinical trial on 2 patient groups with Dupuytren's disease.

    Introduction: Despite an unpredictable outcome, surgery remains an important treatment for Dupuytren's disease. Orthotic devices are a controversial noninvasive treatment method to influence the myofibroblasts in the nodules. Read More

    [Percutaneous needle aponeurotomy for Dupuytren's contracture].
    Orthopade 2017 Apr;46(4):315-320
    Abteilung für Handchirurgie, Vulpius Klinik Bad Rappenau, Vulpiusstraße 29, 70906, Bad Rappenau, Deutschland.
    Dupuytren disease is a benign fibroproliferative disease of the palmar aponeurosis, which can cause considerable functional deficiencies for the person concerned. Partial aponeurectomy is the gold standard in primary surgery. Because it is minimally invasive and has short recovery and low complication rates, the importance of needle aponeurotomy under specific indications has been increasing in the last years. Read More

    Pain Associated With Treatment of Dupuytren Contracture With Collagenase Clostridium histolyticum.
    J Hand Surg Am 2017 Feb;42(2):e109-e114
    College of Human Medicine, Michigan State University, East Lansing; and the UP Health System-Marquette/Duke-LifePoint, Marquette, MI.
    Purpose: The primary objective of this study was to quantify the degree of pain associated with collagenase Clostridium histolyticum (CCH) injection and to determine whether it is related to other factors in the intervention.

    Methods: A prospective study of 135 patients was performed to evaluate pain at 3 points during treatment: (1) after CCH injection, using a numerical rating scale (NRS), (2) a binary (positive/negative) assessment before manipulation 24 hours after CCH and after removing the bandage, and (3) after joint manipulation performed with wrist block anesthesia.

    Results: The average NRS for pain during infiltration was 4. Read More

    To remember: Radiotherapy - a successful treatment for early Dupuytren's disease.
    J Eur Acad Dermatol Venereol 2016 Oct 18;30(10):1694-1699. Epub 2016 Jul 18.
    Department of Dermatology and Allergy Biederstein, Technische Universität München, Munich, Germany.
    Dupuytren's disease (DD) is a common fibroproliferative condition of the hand which tends to cause progressive digital flexion contracture. Therapeutic strategies to treat the disease include radiotherapy, injections of collagenase clostridium histolyticum, needle fasciotomy and extended surgical intervention dependent on involvement and duration of the disease. We have reviewed the literature with the aim to assess the conditions and effects of radiotherapy in DD. Read More

    Collagenase Treatment in Dupuytren Contractures: A Review of the Current State Versus Future Needs.
    Rheumatol Ther 2016 Jun 3;3(1):43-51. Epub 2016 Feb 3.
    Orthopedic Department, Hand Surgery, University Hospitals Leuven, Louvain, Belgium.
    Dupuytren disease is highly prevalent and the finger contractures can be very extensile, compromising the patients' hand function. To restore full function, contractures have been addressed by cutting the causative strands for nearly 200 years, ever since Baron Guillaume Dupuytren demonstrated his technique at the beginning of the nineteenth century. Surgery can be minimal (fasciotomy) or quite invasive (fasciectomy and even skin replacement). Read More

    Effectiveness and safety of collagenase Clostridium histolyticum in Dupuytren's disease : an observational study in Belgium.
    Acta Orthop Belg 2016 Aug;82(2):397-404
    Dupuytren's disease is a connective tissue disorder leading to contractures. It can be treated surgically or through injections of collagenase Clostridium histolyticum (CCH). Patients with Dupuytren's contracture (> 20°) and a palpable cord were included in this observational study, aiming to characterise the Belgian patient population and to assess the effectiveness and safety of CCH. Read More

    Dupuytren in a Child: Rare Presentation of a Rare Clinical Entity.
    J Hand Surg Am 2016 Dec 18;41(12):e477-e479. Epub 2016 Sep 18.
    Clinic of Plastic and Reconstructive Surgery, Aristotle University of Thessaloniki, Papageorgiou General Hospital, Thessaloniki, Greece.
    Dupuytren disease in children younger than 10 years is rare and only 8 histologically proven cases have been reported. A histologically proven Dupuytren disease in a 10-year-old with an uncommon clinical presentation as a nodule on the radial side of the middle phalanx of the little finger is documented. Dupuytren's disease should be in the differential diagnosis in cases of nodules and contractures in the palm and fingers of children. Read More

    Toxic dermatitis secondary to treatment with collagenase clostridium histolyticum for Dupuytren´s disease.
    Eur Rev Med Pharmacol Sci 2016 Sep;20(17):3688-91
    Department of Orthopedic Surgery and Traumatology, Hospital de Denia, Denia - Alicante, Spain.
    Objective: Secondary effects and drug reactions relative to collagenase Clostridium histolyticum treatment for Dupuytren's contracture are frequent. In only a few cases these secondary effects are considered serious. The mechanism that produces these effects of production is not well understood. Read More

    The Impact of Collagenase Clostridium histolyticum Introduction on Dupuytren Treatment Patterns in the United States.
    J Hand Surg Am 2016 Oct 18;41(10):963-968. Epub 2016 Aug 18.
    Department of Orthopedic Surgery, Brigham and Women's Hospital, Boston, MA. Electronic address:
    Purpose: The U.S. Food and Drug Administration approved the use of collagenase Clostridium histolyticum (CCH) in the United States in February 2010. Read More

    Rev Med Chir Soc Med Nat Iasi 2016 Apr-Jun;120(2):244-51
    This article contains bibliographical data concerning the rheumatic clinical manifestations in hypothyroidism: polyarthralgias, lack of recent skill of fine movements of the hands, carpal tunnel syndrome or tarsal, degenerative arthropathy or acute type (gout, chondrocalcinosis), adhesive capsulitis (frozen shoulder syndrome), generalized muscular stiffness, hypothyroid myopathy, secondary osteoarthritis, Dupuytren's contracture, "trigger finger" (also called as stenosing tenosynovitis or trigger thumb) etc. and data on the short history, epidemiology, of these disorders. Review include 60 bibliographical sources. Read More

    Comparison of Treatment Outcome After Collagenase and Needle Fasciotomy for Dupuytren Contracture: A Randomized, Single-Blinded, Clinical Trial With a 1-Year Follow-Up.
    J Hand Surg Am 2016 Sep 27;41(9):873-80. Epub 2016 Jul 27.
    Department of Hand Surgery, Sahlgrenska University Hospital, Gothenburg, Sweden; Centre for Advanced Reconstruction of Extremities, Sahlgrenska University Hospital, Gothenburg, Sweden.
    Purpose: This study compared the efficacy of collagenase treatment and needle fasciotomy for contracture of the metacarpophalangeal (MCP) joint in Dupuytren disease.

    Methods: This is a prospective, single-blinded, randomized study with follow-up 1 week and 1 year after treatment. One hundred and forty patients with an MCP contracture of 20° or more in a single finger were enrolled, of whom 69 patients were randomized to collagenase treatment and 71 patients to needle fasciotomy. Read More

    Measurement Properties of the Brief Michigan Hand Outcomes Questionnaire in Patients With Dupuytren Contracture.
    J Hand Surg Am 2016 Sep 26;41(9):896-902. Epub 2016 Jul 26.
    Department of Teaching, Research and Development, Schulthess Clinic, Zurich, Switzerland.
    Purpose: The brief Michigan Hand Outcomes Questionnaire (briefMHQ) was developed as a shorter version of the Michigan Hand Outcomes Questionnaire (MHQ), but its measurement properties have not been investigated in patients with Dupuytren contracture. The objective of the study was to investigate the reliability, validity, responsiveness, and interpretability of the briefMHQ.

    Methods: Fifty-seven patients diagnosed with Dupuytren contracture completed the briefMHQ as well as the full-length MHQ and Quick Disabilities of the Arm, Shoulder, and Hand (QuickDASH) questionnaire at baseline. Read More

    Dupuytren's Contracture. The Safety and Efficacy of Collagenase Treatment.
    J Hand Surg Asian Pac Vol 2016 Jun;21(2):187-92
    1 Department of Orthopaedic Surgery, St. Olav's University Hospital, Trondheim.
    Background: Our main goal was to see if treatment with collagenase injection is safe and effective and to assess patient satisfaction with this new treatment.

    Methods: We prospectively followed 77 consecutive patients, treated for contracture in 91 fingers and 142 joints that received total of 109 collagenase injections. The patients were reviewed on the first and second day and at 4 and 12 months. Read More

    Collagenase From Vibrio alginolyticus Cultures: Experimental Study and Clinical Perspectives.
    Surg Innov 2016 Dec 22;23(6):557-562. Epub 2016 Jul 22.
    University of Padua, Padua, Italy.
    Purpose The purpose of this study is to examine the activity of collagenase from cultures of Vibrio alginolyticus as in vitro as in biological samples and to evaluate clinical perspectives of this product about the treatment of fibroproliferative diseases like Dupuytren's contracture. Methods The experimental part of the study has been divided in 2 stages. In the first stage, the collagenase has been produced in laboratory, assessing its purity, verifying the in vitro degradation of collagen by the enzyme and measuring the size of the fragments; in the second part, an experimental injection into samples of fibrous cord typical of Dupuytren's disease has been performed in vitro. Read More

    Similar Distributions of Dupuytren's Contracture and Y-Chromosome Haplogroup I Among Modern Europeans Suggest Simultaneous Spreading of These Traits Some 40 to 10 KYA.
    Coll Antropol 2016 Apr;40(1):63-4
    A proposition is made that when two independent traits show similar regional patterns of incidence among modern European regions, a plausible expectation is that these two, otherwise unrelated traits, have simultaneously been spread by migration of our ancestors. As a potential example for the proposed concept, distribution of patients with Dupuytren's contracture is here compared with the reported European distribution of Y-Chromosome Haplogroup I, a genetic marker linked to the last glaciation period. Read More

    Percutaneous Aponeurotomy and Lipofilling (PALF) versus Limited Fasciectomy in Patients with Primary Dupuytren's Contracture: A Prospective, Randomized, Controlled Trial.
    Plast Reconstr Surg 2016 Jun;137(6):1800-12
    Rotterdam, The Netherlands; and Miami, Fla. From the Department of Plastic and Reconstructive Surgery and Hand Surgery, and the Department of Rehabilitation Medicine and Rijndam, Erasmus University Medical Center; and the Miami Hand Center.
    Background: As an alternative to needle aponeurotomy release and limited fasciectomy treatment of Dupuytren's contracture, the authors introduced an extensive percutaneous aponeurotomy and lipofilling (PALF) procedure. In their previous study, the authors reported that contractures significantly improved and most patients returned to normal use of the hand within 2 to 4 weeks. To establish the safety and efficacy of PALF, the authors compared it to the standard limited fasciectomy in a single-blind, multicenter, prospective, randomized, controlled trial. Read More

    [Evaluation of influence of Dupuytryen contracture's operative treatment on increase of quality of hand's function basing on research in use PEM (Patient Evaluation Measure) questionnaire].
    Przegl Lek 2016 ;73(2):83-7
    Introduction: Dupuytren's contracture is a progressive fibrosis of facial structures of the palmar surface of the hand, gradually leading to a reduction of its functions by impaired range of motion of fingers.

    Materials And Methods: Clinical material consisted of 95 patients treated surgically in the Second Department of Surgery of the Jagiellonian University in 2006 - 2011 because of Dupuytren's contracture. Based on a study using PEM questionnaire (Patient Evaluation Measure) an assessment of the quality of life before and after surgery was made. Read More

    Collagenase clostridium histolyticum in Dupuytren's contracture: a systematic review.
    Br Med Bull 2016 Jun 5;118(1):149-58. Epub 2016 May 5.
    Department of Musculoskeletal Disorders, Faculty of Medicine and Surgery, University of Salerno, 84081 Baronissi, Salerno, Italy Centre for Sports and Exercise Medicine, Barts and The London School of Medicine and Dentirstry, Mile End Hospital, 275 Bancroft Road, London E1 4 DG, UK
    Introduction: In the last few years, the use of collagenase clostridium histolyticum for management of Dupuytren's contracture has increased. The procedure of enzymatic fasciectomy has become popular because it is non-invasive, safe and fast to perform.

    Sources Of Data: A systematic search was performed on Medline (PubMed), Web of Science and Scopus databases using the combined keywords 'Dupuytren collagenase' and 'Dupuytren clostridium histolyticum'. Read More

    Needle aponeurotomy for Dupuytren contracture: Effectiveness of postoperative night extension splinting.
    Plast Surg (Oakv) 2016 ;24(1):23-6
    Hand Program, Trillium Health Partners, Toronto, Ontario.
    Background: Night extension splinting has been used to treat patients with Dupuytren contracture to improve active range of motion (AROM) of the hand. A published case study demonstrated the benefit of splinting following needle aponeurotomy; however, no larger studies have evaluated the impact of postoperative splinting.

    Objectives: To compare the impact of night extension splinting on AROM, specifically extension, following needle aponeurotomy for Dupuytren contracture. Read More

    The efficacy of open partial aponeurectomy for recurrent Dupuytren's contracture.
    Arch Orthop Trauma Surg 2016 Jun 1;136(6):881-9. Epub 2016 Apr 1.
    Department of Orthopaedics and Traumatology, University Hospital Cologne, Kerpener Straße 62, 50937, Cologne, Germany.
    Introduction: To evaluate the efficacy of open partial aponeurectomy for recurrent Dupuytren's contracture.

    Methods: Eighteen patients with recurrent Dupuytren's contracture of 22 fingers were retrospectively assessed with a mean follow-up time of 94 months (range: 70-114 months). Examination parameters included the determination of range of motion (ROM), grip strength, pain and subjective outcome (disabilities of the arm, shoulder and hand (DASH) questionnaire). Read More

    Collagenase Dupuytren Contracture: Achieving Single Treatment Success with a Hand Therapist-Based Protocol.
    Plast Reconstr Surg Glob Open 2016 Feb 26;4(2):e629. Epub 2016 Feb 26.
    Department of Plastic and Reconstructive Surgery, University of Texas Southwestern Medical Center, Dallas, Tex.; and Physical Medicine and Rehab, VA North Texas Healthcare System, Physical Medicine and Rehab Service, Dallas, Tex.
    Unlabelled: Surgery remains the gold standard in the treatment of Dupuytren contracture but is technically demanding, carries significant risk of complications, and requires prolonged recovery time. Collagenase injection is an efficacious alternative to surgery; however, contracture release often requires multiple treatments spaced a month apart. We report our experience with a new collagenase treatment protocol aimed to minimize the total treatment time per joint contracture. Read More

    Acta Ortop Bras 2016 Mar-Apr;24(2):98-101
    . Universidade Federal de São Paulo (Unifesp), Escola Paulista de Medicina, Department of Orthopedics and Traumatology, São Paulo, SP, Brazil.
    Objective: : To evaluate and compare the behavior of glycosaminoglycans (GAGs) in Dupuytren disease (DD).

    Methods: : This is an experimental study with 23 patients diagnosed with DD. Tissue collected through fasciectomy with incision type Brunner or McCash were evaluated by electrophoresis for identification of GAGs. Read More

    Collagenase Treatment for Dupuytren Disease of the Thumb and First Web.
    J Hand Surg Am 2016 Mar 21;41(3):348-53.e1. Epub 2016 Jan 21.
    Department of Plastic Surgery, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands.
    Purpose: To evaluate the short-term effectiveness of collagenase Clostridium histolyticum to treat thumb and first web contractures in Dupuytren disease.

    Methods: We prospectively included 14 thumbs in 12 patients with a contracture at the metacarpophalangeal or interphalangeal joint of at least 20° with a palpable cord in the thumb (n = 8) or an adduction contracture of the thumb with palpable cords in the first web (n = 6). They received an injection containing 0. Read More

    Clusters in Short-term Disease Course in Participants With Primary Dupuytren Disease.
    J Hand Surg Am 2016 Mar 16;41(3):354-61; quiz 361. Epub 2016 Jan 16.
    Department of Plastic Surgery, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
    Purpose: The course of Dupuytren disease (DD) is thought to be progressive; however, the course differs for each patient. The purpose of this study was to study the rate and pattern of progression of DD.

    Methods: We prospectively analyzed the course of DD at intervals of 3 to 6 months in 247 Dutch participants with primary DD by measuring the surface area of nodules and cords and the total passive extension deficit. Read More

    Does collagenase injection disrupt or digest the Dupuytren's cord: a magnetic resonance imaging study.
    J Hand Surg Eur Vol 2016 Jul 14;41(6):614-20. Epub 2016 Jan 14.
    The Hospital for Special Surgery, New York, USA
    Unlabelled: Collagenase clostridium histolyticum has been extensively studied as a treatment modality for Dupuytren's contracture. Its mechanism of action has been documented. It is unknown whether injected collagenase weakens the Dupuytren's cord sufficiently to cause failure during manipulation or if there is digestion and reduction in cord volume. Read More

    What are we measuring? A critique of range of motion methods currently in use for Dupuytren's disease and recommendations for practice.
    BMC Musculoskelet Disord 2016 Jan 13;17:20. Epub 2016 Jan 13.
    Kennedy Institute, University of Oxford, Roosevelt Drive, Oxford, OX3 7FY, UK.
    Background: Range of motion is the most frequently reported measure used in practice to evaluate outcomes. A goniometer is the most reliable tool to assess range of motion yet, the lack of consistency in reporting prevents comparison between studies. The aim of this study is to identify how range of motion is currently assessed and reported in Dupuytren's disease literature. Read More

    [Flap plasty in advanced Dupuytren's disease].
    Oper Orthop Traumatol 2016 Feb 4;28(1):20-9. Epub 2016 Jan 4.
    Zentrum für Hand- und Ellenbogenchirurgie, Mikrochirurgie und Plastische Chirurgie, Schön Klinik München-Harlaching, Harlachingerstraße 51, 81547, München, Deutschland.
    Objective: Tension-free skin closure after partial aponeurectomy of fingers in Dupuytren's disease with flexion contracture.

    Indications: Contractures of the proximal interphalangeal (PIP) joint >30° in Dupuytren's disease cannot sufficiently treated by Z-plasty due to the contracted skin conditions.

    Contraindications: Preoperative scar tissue or impaired circulation in the operation region and infections. Read More

    Supplementary arthrolysis of the proximal interphalangeal finger joint in Dupuytren's contracture: primary operation versus revision.
    Arch Orthop Trauma Surg 2016 Mar 29;136(3):435-9. Epub 2015 Dec 29.
    Unfall-, Hand- und Ellenbogenchirurgie, Klinik und Poliklinik für Orthopädie und Unfallchirurgie, Universitätsklinikum zu Köln, Cologne, Germany.
    Introduction: In operative treatment of Dupuytren's disease, in certain cases proximal interphalangeal joint (PIP) flexion contracture remains after fasciectomy which can be corrected by a supplementary arthrolysis, but few data comparing primary and revision surgery are available.

    Materials And Methods: Fifteen patients who had a fasciectomy and supplementary PIP arthrolysis at the affected finger for the first time were compared to 13 patients who had a revision fasciectomy with a supplementary PIP arthrolysis. Upon follow-up at 22 months, flexion contracture was measured and data were compared to the preoperative values. Read More

    Patients' Preferences for Treatment for Dupuytren's Disease: A Discrete Choice Experiment.
    Plast Reconstr Surg 2016 Jan;137(1):165-73
    Rotterdam and Hilversum, The Netherlands From the Departments of Plastic and Reconstructive Surgery and Hand Surgery, Public Health, and Rehabilitation Medicine and Physiotherapy, Erasmus University Medical Centre; and the Xpert Clinic.
    Background: Although in modern medicine, patients' preferences are important, these have never been defined for characteristics of Dupuytren treatment. This study determines these patients' preferences using a discrete choice experiment.

    Methods: A multicenter discrete choice experiment study was conducted among patients with Dupuytren's disease who had been treated previously. Read More

    Dupuytren's disease therapy: targeting the vicious cycle of myofibroblasts?
    Expert Opin Ther Targets 2015 26;19(12):1677-87. Epub 2015 Aug 26.
    a 1 Campus Bio-Medico University of Rome, Department of Orthopaedic and Trauma Surgery , Via Alvaro del Portillo 200, 00128 Rome, Italy +39 06 2254111192 ; +39 06 225411638 ;
    Introduction: Dupuytren's disease (DD) is a proliferative fibromatosis of the hand, which causes permanent flexion contracture of the digits and, ultimately, loss of function. The treatment of DD is complex and involves surgical and nonsurgical approaches, with the goal of removing the affected tissue. New biological targets are under investigation in order to develop innovative therapies. Read More

    Injectable collagenase Clostridium histolyticum as a nonsurgical treatment for Dupuytren's disease.
    Oper Orthop Traumatol 2016 Feb 18;28(1):30-7. Epub 2015 Dec 18.
    Department of Trauma Surgery, Medical University Innsbruck, Anichstraße 35, 6020, Innsbruck, Tirol, Österreich.
    Objective: Nonsurgical treatment of Dupuytren's disease using collagenase Clostridium histolyticum (CCH).

    Indications: Metacarpophalangeal (MP) joint (20-100°) and proximal interphalangeal (PIP) joint (20-80°) contractures.

    Contraindications: Pregnancy, previous hypersensitivity to collagenase or excipients, anticoagulant use within 7 days prior to treatment. Read More

    Surgery for Dupuytren's contracture of the fingers.
    Cochrane Database Syst Rev 2015 Dec 9(12):CD010143. Epub 2015 Dec 9.
    Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences (NDORMS), University of Oxford, Botnar Research Centre, Windmill Road, Oxford, Oxfordshire, UK, OX3 7LD.
    Background: Dupuytren's disease is a benign fibroproliferative disorder that causes the fingers to be drawn into the palm via formation of new tissue under the glabrous skin of the hand. This disorder causes functional limitations, but it can be treated through a variety of surgical techniques. As a chronic condition, it tends to recur. Read More

    [Supplementary arthrolysis of the proximal interphalangeal joint of fingers in surgical treatment of Dupuytren's contracture].
    Oper Orthop Traumatol 2016 Feb 2;28(1):4-11. Epub 2015 Dec 2.
    Klinik für Unfallchirurgie und Orthopädie, Elbe Klinikum Stade, Stade, Deutschland.
    Objective: Correction of residual flexion deformity of the proximal interphalangeal (PIP) joint after excision of diseased connective tissue in Dupuytren's contracture by stepwise arthrolysis.

    Indications: Flexion deformity of the PIP joint of 20° or more after excision of the diseased connective tissue in Dupuytren's contracture.

    Contraindications: Joint deformities, osteoarthrosis, intrinsic muscle contracture, instability of the PIP joint. Read More

    One-year results of needle fasciotomy and collagenase injection in treatment of Dupuytren's contracture: A two-centre prospective randomized clinical trial.
    J Hand Surg Eur Vol 2016 Jul 1;41(6):577-82. Epub 2015 Dec 1.
    Department of Translational Medicine - Hand Surgery, Lund University, Lund, Sweden Department of Hand Surgery, Skåne University Hospital, Malmö, Sweden.
    Unlabelled: The objective of this study was to compare early and 1 year outcome of needle fasciotomy and collagenase injection for Dupuytren's disease. Inclusion criteria were primary Dupuytren's contracture excluding the thumb with a palpable cord and a total extension deficit, i.e. Read More

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