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    2544 results match your criteria Dupuytren Contracture

    1 OF 51

    Effect of Compound 21, a Selective Angiotensin II Type 2 Receptor Agonist, in a Murine Xenograft Model of Dupuytren Disease.
    Plast Reconstr Surg 2017 Nov;140(5):686e-696e
    Halifax, Nova Scotia, Canada From the Department of Microbiology and Immunology and the Department of Surgery, Division of Plastic and Reconstructive Surgery, Dalhousie University; and the Izaak Walton Killam Health Centre.
    Background: Although surgical excision and intralesional collagenase injection are mainstays in Dupuytren disease treatment, no effective medical therapy exists for recurrent disease. Compound 21, a selective agonist of the angiotensin II type 2 receptor, has been shown to protect against fibrosis in models of myocardial infarction and stroke. The authors investigated the potential use of compound 21 in the treatment of Dupuytren disease. Read More

    Variation in Treatment Recommendations for Dupuytren Disease.
    J Hand Surg Am 2017 Sep 23. Epub 2017 Sep 23.
    Division of Plastic and Reconstructive Surgery, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada; University of Toronto, Faculty of Medicine, Toronto, Ontario, Canada. Electronic address:
    Purpose: To examine agreement on Dupuytren disease (DD) treatment recommendations in an international sample of hand surgeons.

    Methods: A survey was developed to determine expertise in needle aponeurotomy, surgery, and collagenase injection to treat DD and to examine treatment recommendations for 16 case scenarios. Case scenarios were predeveloped using expert input. Read More

    A Genome-wide Association Study of Dupuytren Disease Reveals 17 Additional Variants Implicated in Fibrosis.
    Am J Hum Genet 2017 Sep;101(3):417-427
    Nuffield Department of Orthopaedics, Rheumatology, and Musculoskeletal Science, University of Oxford, Botnar Research Centre, Windmill Road, Oxford OX3 7HE, UK; Department of Plastic and Reconstructive Surgery, Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital, Oxford OX3 9DU, UK; NIHR Biomedical Research Centre, NDORMS, University of Oxford, Botnar Research Centre, Windmill Road, Oxford OX3 7HE, UK. Electronic address:
    Individuals with Dupuytren disease (DD) are commonly seen by physicians and surgeons across multiple specialties. It is an increasingly common and disabling fibroproliferative disorder of the palmar fascia, which leads to flexion contractures of the digits, and is associated with other tissue-specific fibroses. DD affects between 5% and 25% of people of European descent and is the most common inherited disease of connective tissue. Read More

    Night Orthosis After Surgical Correction of Dupuytren Contractures: A Systematic Review.
    J Hand Surg Am 2017 Oct 1;42(10):839.e1-839.e10. Epub 2017 Sep 1.
    Division of Plastic and Reconstructive Surgery, College of Medicine, Dalhousie University, Halifax, Nova Scotia.
    Purpose: To determine the role of night orthosis use after surgical correction of Dupuytren contracture.

    Methods: We searched MEDLINE, EMBASE, CINAHL, AMED, OTSeeker, and CENTRAL for articles published from inception of the databases to August 2015. Assessment was undertaken by 2 independent reviewers (O. Read More

    Efficacy and safety of collagenase clostridium histolyticum for Dupuytren disease nodules: a randomized controlled trial.
    BMC Musculoskelet Disord 2017 Aug 30;18(1):374. Epub 2017 Aug 30.
    OrthoCarolina, 1915 Randolph Rd, Charlotte, NC, 28207, USA.
    Background: To determine the safety and efficacy of collagenase clostridium histolyticum (CCH) injection for the treatment of palmar Dupuytren disease nodules.

    Methods: In this 8-week, double-blind trial, palpable palmar nodules on one hand of adults with Dupuytren disease were selected for treatment. Patients were randomly assigned using an interactive web response system to receive a dose of 0. Read More

    Readability of online materials for Dupuytren's contracture.
    J Hand Ther 2017 Aug 23. Epub 2017 Aug 23.
    Department of Plastic Surgery, University of California Irvine, Orange, CA, USA.
    Study Design: Descriptive.

    Background: Dupuytren's contracture is a common disorder involving fibrosis of the palmar fascia. As patients are increasingly using online materials to gather health care information, it is imperative to assess the readability and appropriateness of this content. Read More

    Benefit of Local Anesthesia in Reducing Pain during Collagenase Injection for Dupuytren's Contracture.
    Plast Reconstr Surg 2017 Sep;140(3):565-569
    Hässleholm, Lund, Linköping, and Ängelholm, Sweden From the Department of Orthopedics, Hässleholm-Kristianstad Hospitals; the Department of Clinical Sciences-Orthopedics, Lund University; the Department of Medical and Health Sciences, Linköping University; and the Department of Orthopedics Aleris, Ängelholm Hospital.
    Collagenase injection for Dupuytren's contracture is commonly administered without anesthesia. The authors studied the benefit of injecting local anesthesia before collagenase in reducing treatment-related pain. This prospective cohort study included 187 patients (mean age, 69 years; 80 percent men) at two orthopedic departments in Sweden. Read More

    Dupuytren-Like Contracture of the Foot: Ledderhose Disease.
    Surg J (N Y) 2016 Jul 21;2(3):e102-e104. Epub 2016 Sep 21.
    Department of Plastic, Reconstructive, and Aesthetic Surgery, Selcuk University Medical Faculty, Konya, Turkey.
    Introduction  Plantar fibromatosis is a rare hyperproliferative disease of plantar aponeurosis and is also called Ledderhose disease. Case properties and treatment are discussed in this report. Case Report  A 30-year-old man presented with painful bilateral plantar nodules. Read More

    Low second to fourth digit ratio in Dupuytren disease.
    Medicine (Baltimore) 2017 Aug;96(33):e7801
    aDepartment of Orthopaedic Surgery, Osaka City University Graduate School of Medicine, Osaka bGakuen-minami Clinic, Nara, Japan.
    The ratio of the lengths of the second and fourth digits (2D:4D) has been described as reflecting endogenous prenatal androgen exposure. In general, 2D:4D is lower in men than in women and has potential as a biomarker or predictor for various diseases, athletic ability, and academic performance. Dupuytren disease has digital flexion contractures and is known to predominate in men, but the pathogenesis of the disease remains unclear. Read More

    The Hand of Sabazios: Evidence of Dupuytren's Disease in Antiquity and the Origin of the Hand of Benediction.
    J Hand Surg Asian Pac Vol 2017 Sep;22(3):403-410
    1 Department of Natural Sciences and Mathematics, West Liberty University, West Liberty, WV, USA.
    Dupuytren's disease gained its eponym from the surgeon Baron Guillaume Dupuytren (1777-1835). However, the terms "Cline's contracture" and "Cooper's contracture," named after the two surgeons who proposed the treatment for the palmar contractures prior to Dupuytren, have also been used to describe the disease. In addition to the eponyms attributed to these three surgeons, a number of other appellations with interesting provenance exist for Dupuytren's disease including the "Curse of the MacCrimmons," "Celtic hand," "Viking's disease," and the "Hand of Benediction. Read More

    Efficacy and safety of collagenase treatment for Dupuytren's disease: 2-year follow-up results.
    Hand Surg Rehabil 2017 Oct 18;36(5):346-349. Epub 2017 Jul 18.
    Orthopedic department, Monica hospital, 68, Harmoniestraat, 2018 Antwerp, Belgium.
    Dupuytren's contracture is a common hand problem that affects the palmar fascia. Several treatment options exist, but none are curative and recurrence is common. Bacterial collagenase has recently been proven beneficial for treating Dupuytren's disease, cleaving the collagen fibers at different sites, with weakening and eventually rupture of the fibrous cords after manipulation. Read More

    Preliminary results with non-centrifuged autologous fat graft and percutaneous aponeurotomy for treating Dupuytren's disease.
    Hand Surg Rehabil 2017 Oct 18;36(5):350-354. Epub 2017 Jul 18.
    Gaziosmanpaşa university, faculty of medicine, department of biostatistics, 60250 Tokat, Turkey. Electronic address:
    The aim of this study was to describe our experience with treating Dupuytren's disease using needle aponeurotomy and non-centrifuged autologous fat grafting. The study included 17 patients (18 hands). Patients were treated with needle aponeurotomy and non-centrifuged autologous fat graft under general anesthesia. Read More

    Dupuytren's contracture and handwork: A case-control study.
    Am J Ind Med 2017 Aug;60(8):724-733
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Canada.
    Objective: The objective of this study was to examine the association between Dupuytren's contracture (DC), repetitive handwork (RHW), heavy handwork (HHW), and/or vibration exposure.

    Methods: Frequency and intensity of the three types of handwork were collected and compared between DC patients and controls. Hours of work were weighted by average "frequency," for RHW, and average "intensity," for HHW and use of vibrating tool. Read More

    The Incidence of Complex Regional Pain Syndrome in Simultaneous Surgical Treatment of Carpal Tunnel Syndrome and Dupuytren Contracture.
    Hand (N Y) 2017 Jul 1:1558944717718345. Epub 2017 Jul 1.
    1 University of Louisville School of Medicine, KY, USA.
    Background: To determine the incidence of complex regional pain syndrome (CRPS) in the concurrent surgical treatment of Dupuytren contracture (DC) and carpal tunnel syndrome (CTS) through a thorough review of evidence available in the literature.

    Methods: The indices of 260 hand surgery books and PubMed were searched for concomitant references to DC and CTS. Studies were eligible for inclusion if they evaluated the outcome of patients treated with simultaneous fasciectomy or fasciotomy for DC and carpal tunnel release using CRPS as a complication of treatment. Read More

    Involvement of the Interosseous and Lumbrical Muscle-Tendon Units in the Lateral and Spiral Cords in Dupuytren's Disease of the Middle Fingers.
    Plast Reconstr Surg 2017 Jul;140(1):116-124
    Hamilton, Ontario, Canada From the Division of Plastic Surgery, Department of Surgery, and the Faculty of Health Science, McMaster University.
    Background: The nature of intrinsic muscle involvement in Dupuytren's disease of the middle fingers (long and ring) remains poorly characterized. Over the years, the authors have observed that both the spiral and lateral digital cords in the middle fingers receive contribution from intrinsic muscle-tendon units. This report describes the anatomical characteristics and frequency of intrinsic muscle-tendon unit involvement in Dupuytren's disease of the middle fingers. Read More

    Use of adipose tissue and stromal vascular fraction in hand surgery.
    Orthop Traumatol Surg Res 2017 Oct 20;103(6):927-932. Epub 2017 Jun 20.
    Service de chirurgie plastique et chirurgie de la main, CHU de Rouen, 1, rue de Germont, 76000 Rouen, France. Electronic address:
    Adipose tissue is an abundant source of various cell types including not only adipocytes, but also progenitor and endothelial cells from thestroma. Interest in adipose tissue has surged since the identification in 2001 of adipose-derived stem cells (ADSCs) and of the stromal vascular fraction (SVF) obtained from adipose tissue by enzymatic digestion and centrifugation. SVF has been proven effective in ensuring tissue regeneration, thus improving tissue trophicityand vascularisation. Read More

    Surgical treatment results for dupuytren's disease.
    Acta Ortop Bras 2017 May-Jun;25(3):71-73
    Metin Sabancı Baltalimanı Bone Diseases Training and Research Hospital, Department of Hand Surgery, Istanbul, Turkey.
    Objective: To present the results of our cases of Dupuytren's disease treated with regional selective fasciectomy in light of the literature.

    Methods: Patients diagnosed with Dupuytren's contracture and surgically treated with regional selective fasciectomy at our institution with adequate follow-up data were included in the study. All patients were routinely followed after surgery to assess results and complications. Read More

    Complications Following Collagenase Treatment for Dupuytren Contracture.
    Hand (N Y) 2017 Sep 21;12(5):NP148-NP151. Epub 2017 Jun 21.
    1 Oregon Health & Science University, Portland, USA.
    Background: Collagenase Clostridium histolyticum (CCH) injection and manipulation is a relatively new method for treating Dupuytren contracture that is growing in popularity. Although side effects such as swelling and ecchymosis are common, they are typically mild and self-limited. Major complications are rare but have included flexor tendon rupture and complex regional pain syndrome. Read More

    Outcome of Dupuytren Contractures After Collagenase Clostridium Histolyticum Injection: A Single-institution Experience.
    Ann Plast Surg 2017 Aug;79(2):145-148
    From the *Plastic Surgery Specialists of South Florida, Hollywood; †Department of Plastic and Reconstructive Surgery, Cleveland Clinic Florida, Weston; and ‡School of Medicine, Florida Atlantic University, Boca Raton, FL.
    Background: Collagenase clostridium histolyticum (CCH) injection is an alternative to surgery for patients with Dupuytren disease (DD) of the metacarpophalangeal (MCP) and proximal interphalangeal (PIP) joints. The success of surgical and nonsurgical treatment modalities for DD is reported to vary widely between 25% and 80% (J Bone Joint Surg Am. 1985;67:1439-1443; Plast Reconstr Surg. Read More

    Early Postoperative Results of Percutaneous Needle Fasciotomy in 451 Patients with Dupuytren Disease.
    Plast Reconstr Surg 2017 Jun;139(6):1415-1421
    Groningen, The Netherlands From the Department of Plastic Surgery, University of Groningen and University Medical Center Groningen; and the Department of Rheumatology, Medical Center Alkmaar.
    Background: Percutaneous needle fasciotomy is a minimally invasive treatment modality for Dupuytren disease. In this study, the authors analyzed the efficacy and complication rate of percutaneous needle fasciotomy using a statistical method that takes the multilevel structure of data, regarding multiple measurements from the same patient, into account.

    Methods: The data of 470 treated rays from 451 patients with Dupuytren disease that underwent percutaneous needle fasciotomy were analyzed retrospectively. Read More

    Recurrence of Dupuytren's contracture: A consensus-based definition.
    PLoS One 2017 15;12(5):e0164849. Epub 2017 May 15.
    Department of Plastic and Reconstructive Surgery and Hand Surgery, Erasmus Medical Center, Rotterdam, the Netherlands.
    Purpose: One of the major determinants of Dupyutren disease (DD) treatment efficacy is recurrence of the contracture. Unfortunately, lack of agreement in the literature on what constitutes recurrence makes it nearly impossible to compare the multiple treatments alternatives available today. The aim of this study is to bring an unbiased pool of experts to agree upon what would be considered a recurrence of DD after treatment; and from that consensus establish a much-needed definition for DD recurrence. Read More

    Injectable Collagenase Versus Percutaneous Needle Fasciotomy for Dupuytren Contracture in Proximal Interphalangeal Joints: A Randomized Controlled Trial.
    J Hand Surg Am 2017 May;42(5):321-328.e3
    Interdisciplinary Research Unit, Center for Planned Surgery, Silkeborg, Denmark; Orthopaedic Research Unit, Department of Orthopaedic Surgery, Aarhus University Hospital, Aarhus, Denmark.
    Purpose: Collagenase Clostridium histolyticum (CCH) injection was introduced commercially as a treatment for Dupuytren contracture following initial phase-3 investigations in 2009 with promising results. However, the efficacy of CCH has not been prospectively investigated in a direct comparison to other active treatments of Dupuytren contracture with more than 1-year follow-up, despite a wide and increasing clinical use.

    Method: In this prospective, independent, open-label, randomized controlled trial, (Clinicaltrials. Read More

    Reply: Percutaneous Aponeurotomy and Lipofilling (PALF) versus Limited Fasciectomy in Patients with Primary Dupuytren's Contracture: A Prospective, Randomized, Controlled Trial.
    Plast Reconstr Surg 2017 08;140(2):358e-359e
    Department of Plastic, Reconstructive, and Hand Surgery, Erasmus Medical Center, Rotterdam, The Netherlands Department of Plastic, Reconstructive, and Hand Surgery, Department of Rehabilitation Medicine at Rijndam, Erasmus Medical Center, Rotterdam, The Netherlands Department of Plastic, Reconstructive, and Hand Surgery, Erasmus Medical Center, Rotterdam, The Netherlands Miami Hand Center, Miami, Fla. Department of Plastic, Reconstructive, and Hand Surgery, Erasmus Medical Center, Rotterdam, The Netherlands.

    The Use of Residual Collagenase for Single Digits With Multiple-Joint Dupuytren Contractures.
    J Hand Surg Am 2017 Jun 4;42(6):472.e1-472.e6. Epub 2017 Apr 4.
    Department of Orthopaedic Surgery, Geisinger Medical Center, Danville, PA.
    Purpose: Standard 0.58 mg (0.25 mL) collagenase Clostridium histolyticum (CCH) preparations result in unused CCH that is often discarded. Read More

    Treatment of Recurrent Dupuytren Contracture in Joints Previously Effectively Treated With Collagenase Clostridium histolyticum.
    J Hand Surg Am 2017 May 22;42(5):391.e1-391.e8. Epub 2017 Mar 22.
    Endo Pharmaceuticals Inc., Malvern, PA.
    Purpose: Collagenase Clostridium histolyticum (CCH) is approved for the treatment of adults with Dupuytren contracture with a palpable cord. This open-label, phase 4 study evaluated the safety and efficacy of CCH for the retreatment of recurrent contractures in joints that were previously effectively treated with CCH.

    Methods: Patients participating in a long-term follow-up study who had contracture recurrence (increased ≥ 20° with a palpable cord) after successful treatment in the previous study were eligible. Read More

    Acute Gout Following Dermofasciectomy in a Patient With Dupuytren Disease.
    J Hand Surg Am 2017 Jan 27;42(1):e49-e50. Epub 2016 Oct 27.
    Sheffield Hand Unit, Northern General Hospital, Sheffield, United Kingdom.
    A 62-year-old man underwent uncomplicated dermofasciectomy of the right little finger. In the week after surgery, he presented with erythema, tenderness, reduced range of movement, and a chalklike discharge from the suture line. Investigations revealed a raised serum urate level accompanied with a borderline rise in inflammatory markers. Read More

    Collagenase injections for Dupuytren's disease: prospective cohort study assessing 2-year treatment effect durability.
    BMJ Open 2017 Mar 15;7(3):e012943. Epub 2017 Mar 15.
    Department of Orthopedics, Hässleholm-Kristianstad-Ystad Hospitals, Hässleholm, Sweden.
    Objectives: To assess 2-year durability of joint contracture correction following collagenase injections for Dupuytren's disease.

    Design: Prospective cohort study.

    Setting: Orthopaedic Department in Sweden. Read More

    Modified McCash Technique for Management of Dupuytren Contracture.
    J Hand Surg Am 2017 05 1;42(5):395.e1-395.e5. Epub 2017 Mar 1.
    Hand and Upper Extremity Center, Wexford, PA.
    Despite recent advancements in the nonsurgical treatment for Dupuytren contracture, a number of patients remain poor nonsurgical candidates or elect for surgical management. The traditional McCash technique releases contractures while leaving open palmar wounds. Although successful in alleviating contractures, these wounds are traditionally large, transverse incisions across the palm. Read More

    [Primary intervention in Dupuytren's disease].
    Orthopade 2017 Apr;46(4):336-341
    Abteilung für Plastische-, Hand- und Rekonstruktive Chirurgie, BG-Unfallklinik Frankfurt am Main, Friedberger Landstraße 430, 60389, Frankfurt am Main, Deutschland.
    Partial aponeurectomy as the state-of-the-art treatment in Dupuytren's disease is indicated when minimally invasive forms of treatment, such as needle aponeurotomy or percutaneous collagenase injection, are not possible due to the advanced stage of the disease or the morphology of the contracture. Even in earlier stages of Dupuytren disease partial aponeurectomy has advantages in comparison to minimally invasive forms of treatment. These advantages are lower recurrence rates as well as less persistent residual contractures, especially in the proximal interphalangeal joint. Read More

    A clinical trial of tension and compression orthoses for Dupuytren contractures.
    J Hand Ther 2017 Jul - Sep;30(3):253-261. Epub 2017 Feb 21.
    Orthopaedic Department, Hand Unit, University Hospitals Leuven, Pellenberg Campus, Pellenberg, Belgium.
    Study Design: Randomized clinical trial on 2 patient groups with Dupuytren's disease.

    Introduction: Despite an unpredictable outcome, surgery remains an important treatment for Dupuytren's disease. Orthotic devices are a controversial noninvasive treatment method to influence the myofibroblasts in the nodules. Read More

    Adverse Effects of Collagenase in the Treatment of Dupuytren Disease: A Systematic Review.
    BioDrugs 2017 Apr;31(2):105-115
    University of Granada, Granada, Spain.
    Background: Collagenase clostridium histolyticum (CCH) has proven to be both safe and effective in the treatment of Dupuytren disease (DD). The medium-term outcomes are similar to those achieved with surgery, and most adverse effects are self-limiting and considered to be mild or moderate.

    Objective: Our objective was to conduct a systematic review of the adverse effects of CCH in DD since the release of the drug to evaluate the incidence, severity, classification, and definitions of these effects. Read More

    [Percutaneous needle aponeurotomy for Dupuytren's contracture].
    Orthopade 2017 Apr;46(4):315-320
    Abteilung für Handchirurgie, Vulpius Klinik Bad Rappenau, Vulpiusstraße 29, 70906, Bad Rappenau, Deutschland.
    Dupuytren disease is a benign fibroproliferative disease of the palmar aponeurosis, which can cause considerable functional deficiencies for the person concerned. Partial aponeurectomy is the gold standard in primary surgery. Because it is minimally invasive and has short recovery and low complication rates, the importance of needle aponeurotomy under specific indications has been increasing in the last years. Read More

    Pain Associated With Treatment of Dupuytren Contracture With Collagenase Clostridium histolyticum.
    J Hand Surg Am 2017 Feb;42(2):e109-e114
    College of Human Medicine, Michigan State University, East Lansing; and the UP Health System-Marquette/Duke-LifePoint, Marquette, MI.
    Purpose: The primary objective of this study was to quantify the degree of pain associated with collagenase Clostridium histolyticum (CCH) injection and to determine whether it is related to other factors in the intervention.

    Methods: A prospective study of 135 patients was performed to evaluate pain at 3 points during treatment: (1) after CCH injection, using a numerical rating scale (NRS), (2) a binary (positive/negative) assessment before manipulation 24 hours after CCH and after removing the bandage, and (3) after joint manipulation performed with wrist block anesthesia.

    Results: The average NRS for pain during infiltration was 4. Read More

    Dupuytren's Contracture.
    Workplace Health Saf 2017 Mar 9;65(3):96-99. Epub 2017 Jan 9.
    1 California State University, Monterey Bay.
    Dupuytren's disorder is considered a genetic disorder and therefore not covered under workers' compensation. Personal risk factors include workers of Northern European descent and workers that are older than 50 years. However, new evidence has shown that certain occupational activities may increase the risk of developing this disorder. Read More

    Evidence-Based Medicine: Options for Dupuytren's Contracture: Incise, Excise, and Dissolve.
    Plast Reconstr Surg 2017 Jan;139(1):240e-255e
    San Francisco, Calif. From the Division of Plastic Surgery, University of California, San Francisco.
    Learning Objectives: After studying this article, the participant should be able to: 1. Understand updates in the basic science, epidemiology, and treatment of Dupuytren's disease. 2. Read More

    Effectiveness of Occupational Therapy Interventions for Adults With Musculoskeletal Conditions of the Forearm, Wrist, and Hand: A Systematic Review.
    Am J Occup Ther 2017 Jan/Feb;71(1):7101180010p1-7101180010p12
    Mark E. Hardison, MS, OTR/L, is PhD Student, Mrs. T. H. Chan Division of Occupational Science and Occupational Therapy, University of Southern California, Los Angeles.
    Occupational therapy practitioners are key health care providers for people with musculoskeletal disorders of the distal upper extremity. It is imperative that practitioners understand the most effective and efficient means for remediating impairments and supporting clients in progressing to independence in purposeful occupations. This systematic review provides an update to a previous review by summarizing articles published between 2006 and July 2014 related to the focused question, What is the evidence for the effect of occupational therapy interventions on functional outcomes for adults with musculoskeletal disorders of the forearm, wrist, and hand? A total of 59 articles were reviewed. Read More

    To remember: Radiotherapy - a successful treatment for early Dupuytren's disease.
    J Eur Acad Dermatol Venereol 2016 Oct 18;30(10):1694-1699. Epub 2016 Jul 18.
    Department of Dermatology and Allergy Biederstein, Technische Universität München, Munich, Germany.
    Dupuytren's disease (DD) is a common fibroproliferative condition of the hand which tends to cause progressive digital flexion contracture. Therapeutic strategies to treat the disease include radiotherapy, injections of collagenase clostridium histolyticum, needle fasciotomy and extended surgical intervention dependent on involvement and duration of the disease. We have reviewed the literature with the aim to assess the conditions and effects of radiotherapy in DD. Read More

    Collagenase Treatment in Dupuytren Contractures: A Review of the Current State Versus Future Needs.
    Rheumatol Ther 2016 Jun 3;3(1):43-51. Epub 2016 Feb 3.
    Orthopedic Department, Hand Surgery, University Hospitals Leuven, Louvain, Belgium.
    Dupuytren disease is highly prevalent and the finger contractures can be very extensile, compromising the patients' hand function. To restore full function, contractures have been addressed by cutting the causative strands for nearly 200 years, ever since Baron Guillaume Dupuytren demonstrated his technique at the beginning of the nineteenth century. Surgery can be minimal (fasciotomy) or quite invasive (fasciectomy and even skin replacement). Read More

    Effectiveness and safety of collagenase Clostridium histolyticum in Dupuytren's disease : an observational study in Belgium.
    Acta Orthop Belg 2016 Aug;82(2):397-404
    Dupuytren's disease is a connective tissue disorder leading to contractures. It can be treated surgically or through injections of collagenase Clostridium histolyticum (CCH). Patients with Dupuytren's contracture (> 20°) and a palpable cord were included in this observational study, aiming to characterise the Belgian patient population and to assess the effectiveness and safety of CCH. Read More

    Dupuytren in a Child: Rare Presentation of a Rare Clinical Entity.
    J Hand Surg Am 2016 12 18;41(12):e477-e479. Epub 2016 Sep 18.
    Clinic of Plastic and Reconstructive Surgery, Aristotle University of Thessaloniki, Papageorgiou General Hospital, Thessaloniki, Greece.
    Dupuytren disease in children younger than 10 years is rare and only 8 histologically proven cases have been reported. A histologically proven Dupuytren disease in a 10-year-old with an uncommon clinical presentation as a nodule on the radial side of the middle phalanx of the little finger is documented. Dupuytren's disease should be in the differential diagnosis in cases of nodules and contractures in the palm and fingers of children. Read More

    Toxic dermatitis secondary to treatment with collagenase clostridium histolyticum for Dupuytren´s disease.
    Eur Rev Med Pharmacol Sci 2016 Sep;20(17):3688-91
    Department of Orthopedic Surgery and Traumatology, Hospital de Denia, Denia - Alicante, Spain.
    Objective: Secondary effects and drug reactions relative to collagenase Clostridium histolyticum treatment for Dupuytren's contracture are frequent. In only a few cases these secondary effects are considered serious. The mechanism that produces these effects of production is not well understood. Read More

    Predictors of Patient Satisfaction with Hand Function after Fasciectomy for Dupuytren's Contracture.
    Plast Reconstr Surg 2016 Sep;138(3):649-55
    Rotterdam and Hilversum, The Netherlands From the Departments of Plastic, Reconstructive and Hand Surgery and Rehabilitation Medicine, Erasmus MC; and the Department of Hand and Wrist Surgery, Xpert Clinic.
    Background: This study examined patient satisfaction with hand function after fasciectomy for Dupuytren's contracture and determined which preoperative patient- and disease-specific factors predicted this satisfaction.

    Methods: Demographics and disease-specific factors were assessed from a prospective cohort of 194 patients who completed the Michigan Hand Outcomes Questionnaire preoperatively and underwent limited fasciectomy between 2011 and 2014 at six hand surgery practice sites. To evaluate satisfaction with hand function, patients were asked to complete the Michigan Hand Outcomes Questionnaire during the first year after fasciectomy. Read More

    The Impact of Collagenase Clostridium histolyticum Introduction on Dupuytren Treatment Patterns in the United States.
    J Hand Surg Am 2016 Oct 18;41(10):963-968. Epub 2016 Aug 18.
    Department of Orthopedic Surgery, Brigham and Women's Hospital, Boston, MA. Electronic address:
    Purpose: The U.S. Food and Drug Administration approved the use of collagenase Clostridium histolyticum (CCH) in the United States in February 2010. Read More

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