4,724 results match your criteria Dupuytren Contracture


[Graft reinjection: Guidelines from the Francophone Society of Bone Marrow Transplantation and Cellular Therapy (SFGM-TC)].

Bull Cancer 2018 Dec 7. Epub 2018 Dec 7.

Unité de soins intensifs, CLCC Becquerel, 1, rue d'Amiens, 76000 Rouen, France.

JACIE (Joint Accreditation Committee ISTC EBMT) regulations and standards impose a quality and safety requirement for graft reinjection by nurses. However, the standards do not provide a step-by-step graft reinjection procedure. Because of high medical team turnover, the opening of new transplant centers, and continual questions from colleagues trying to decipher the JACIE standards, the need for a specific procedure goes without saying. Read More

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December 2018

FranceCoag: a 22-year prospective follow-up of the national French cohort of patients with inherited bleeding disorders.

Eur J Epidemiol 2018 Dec 5. Epub 2018 Dec 5.

Haemophilia Treatment Centre, APHM, Children Hospital La Timone, Aix Marseille University, INSERM, INRA, C2VN, Marseille, France.

FranceCoag is an ongoing open prospective multicentre cohort project aimed at improving epidemiological knowledge about inherited bleeding disorders in France. The main objective of this article was to evaluate the project's progress as of the 30th December 2016. Between 1994 and this date, of the 10,047 patients included in the study, 384 (3. Read More

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December 2018
3 Reads

Percutaneous Aponeurotomy and Lipofilling versus Limited Fasciectomy for Dupuytren's Contracture: 5-Year Results from a Randomized Clinical Trial.

Plast Reconstr Surg 2018 Dec;142(6):1523-1531

Rotterdam and Utrecht, The Netherlands From the Department of Plastic and Reconstructive Surgery and Hand Surgery and the Department of Rehabilitation Medicine and Physical Therapy, Erasmus Medical Center; the Xpert Clinic, Hand and Wrist Center; and Handtherapie Nederland.

Background: In the Dupuytren Rotterdam randomized controlled trial, percutaneous aponeurotomy with lipofilling (PALF) was as effective as limited fasciectomy in correcting primary Dupuytren's contracture after 1 year. The authors report the 5-year results of this trial, with a special focus on recurrence of contractures.

Methods: The authors invited all patients who had undergone PALF or limited fasciectomy to participate in a posttrial follow-up assessment. Read More

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December 2018
3 Reads

3-Dimensional fasciectomy: A highly efficacious common ground approach to Dupuytren's surgery.

Arch Plast Surg 2018 Nov 15;45(6):557-563. Epub 2018 Nov 15.

Department Plastic and Reconstructive Surgery, Countess of Chester Hospital NHS Foundation Trust, Chester, UK.

Background: Numerous Dupuytren's fasciectomy techniques have been described, each associated with unique surgical challenges, complications and recurrence rates. We describe a common ground surgical approach to Dupuytren's disease; 3-dimensional fasciectomy (3DF). 3DF aims to address the potential contributors to the high recurrence rate of Dupuytren's disease and unite current limited fasciectomy practice that varies considerably between surgeons. Read More

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November 2018
2 Reads

Pesticides Exposure by Air in Vineyard Rural Area and Respiratory Health in Children: A pilot study.

Environ Res 2018 Nov 10;169:189-195. Epub 2018 Nov 10.

Univ. Bordeaux, Inserm, Bordeaux Population Health Research Center, team EPICENE, UMR 1219, F-33000 Bordeaux, France; Laboratoire de Pharmacologie Clinique et de Toxicologie, CHU Bordeaux, France.

Rationale: Asthma, frequently associated with rhinitis, is the most common chronic disease in children, and a significant role is played by a range of environmental exposures. Among them, air pollution is of foremost concern. However, little is known about the impact of airborne pesticide exposure on children's respiratory health in rural areas. Read More

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November 2018
3 Reads

Local carotid arterial stiffness is an independent determinant of left ventricular remodeling in never-treated hypertensive patients.

Blood Press 2018 Nov 22:1-10. Epub 2018 Nov 22.

f Department of Internal Medicine , University of Padova , Padua , Italy.

Purpose: The aim was to investigate the association between blood pressure (BP), carotid stiffness, carotid-femoral pulse wave velocity (cfPWV) and left ventricular (LV) remodeling in never-treated hypertensive patients.

Material And Methods: 178 never-treated hypertensive underwent transthoracic echocardiography, 24-hour ambulatory BP monitoring (ABPM), local carotid stiffness and regional cfPWV assessed using a high-definition echo-tracking ultrasound system and a tonometric transducer, respectively. LV parameters and arterial stiffness were also considered in dippers and non-dippers. Read More

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November 2018
3 Reads

Mid- and long-term prognosis of off- vs. on-pump coronary artery bypass graft in patients with multisite artery disease.

J Cardiovasc Surg (Torino) 2018 Nov 20. Epub 2018 Nov 20.

CHU Limoges, Service of Cardiology, Dupuytren Hospital, Limoges, France -

Background: Among patients with coronary artery disease (CAD), around 25% have multisite artery disease (MSAD). Patients with CAD and MSAD are at higher risk of peri-operative and long-term cardiovascular events. Whether off-pump coronary bypass grafting (CABG) can improve their prognosis is unknown. Read More

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November 2018

Overview of the pathological results and treatment characteristics in the first 1000 patients randomized in the SERC trial: axillary dissection versus no axillary dissection in patients with involved sentinel node.

BMC Cancer 2018 Nov 21;18(1):1153. Epub 2018 Nov 21.

Institut Paoli Calmettes & CRCM & Aix Marseille Univ, 232 Bd de Sainte Marguerite, 13009, Marseille, France.

Background: Three randomized trials have concluded at non inferiority of omission of complementary axillary lymph node dissection (cALND) for patients with involved sentinel node (SN). However, we can outline strong limitations of these trials to validate this attitude with a high scientific level. We designed the SERC randomized trial ( ClinicalTrials. Read More

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November 2018
8 Reads

Host-pathogen interactions and prognosis of critically ill immunocompetent patients with pneumococcal pneumonia: the nationwide prospective observational STREPTOGENE study.

Intensive Care Med 2018 Dec 19;44(12):2162-2173. Epub 2018 Nov 19.

Hôpital Cochin, Réanimation Médicale, 75679, Paris Cedex 14, France.

Purpose: To assess the relative importance of host and bacterial factors associated with hospital mortality in patients admitted to the intensive care unit (ICU) for pneumococcal community-acquired pneumonia (PCAP).

Methods: Immunocompetent Caucasian ICU patients with PCAP documented by cultures and/or pneumococcal urinary antigen (UAg Sp) test were included in this multicenter prospective study between 2008 and 2012. All pneumococcal strains were serotyped. Read More

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December 2018
2 Reads

Adult Bone Marrow Three-Dimensional Phenotypic Landscape of B-Cell Differentiation.

Cytometry B Clin Cytom 2018 Nov 18. Epub 2018 Nov 18.

UMR CNRS 7276, Contrôle de la Réponse Immune et des Lymphoproliférations, Université de Limoges, Limoges, France.

Background: The different B-cell subsets in human bone marrow result from a dynamic equilibrium between endogenous production, B-cell bone marrow reentry and terminal plasma cell differentiation. Our aim was to define and quantify the different medullary B-cell subsets.

Methods: A series of 32 normal adult bone marrows plus 15 normal adult blood samples was studied by nine color flow cytometry (CD10, CD19, CD24, CD27, CD34, CD38, CD45, IgM, and IgD). Read More

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November 2018
6 Reads

Proenkephalin A 119-159 (Penkid) Is an Early Biomarker of Septic Acute Kidney Injury: The Kidney in Sepsis and Septic Shock (Kid-SSS) Study.

Kidney Int Rep 2018 Nov 22;3(6):1424-1433. Epub 2018 Aug 22.

Department of Anaesthesiology, Burn and Critical Care Medicine, AP-HP, Saint Louis and Lariboisière University Hospitals, Paris, France.

Introduction: Sepsis is the leading cause of acute kidney injury (AKI) in critically ill patients. The Kidney in Sepsis and Septic Shock (Kid-SSS) study evaluated the value of proenkephalin A 119-159 (penkid)-a sensitive biomarker of glomerular function, drawn within 24 hours upon intensive care unit (ICU) admission and analyzed using a chemiluminescence immunoassay-for kidney events in sepsis and septic shock.

Methods: The Kid-SSS study was a substudy of Adrenomedullin and Outcome in Severe Sepsis and Septic Shock (AdrenOSS) (NCT02393781), a prospective, observational, multinational study including 583 patients admitted to the intensive care unit with sepsis or septic shock and a validation cohort of 525 patients from the French and euRopean Outcome reGistry in Intensive Care Units (FROG-ICU) study. Read More

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November 2018
3 Reads

The intrinsic prognostic value of the ankle-brachial index is independent from its mode of calculation.

Vasc Med 2018 Nov 14:1358863X18807003. Epub 2018 Nov 14.

1 CHU Limoges, Hôpital Dupuytren, Service Cardiologie, Limoges, France.

The object of this study was to compare the prognostic value of different methods of ankle-brachial index (ABI) calculation. From April 1998 to September 2008, we calculated the ABI in 1223 patients before coronary artery bypass grafting. The ABI was calculated according to five different calculation modes of the numerator. Read More

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November 2018
1 Read

Durability of Collagenase Treatment for Dupuytren Disease of the Thumb and First Web After at Least 2 Years' Follow-Up.

J Hand Surg Am 2018 Nov 9. Epub 2018 Nov 9.

Department of Plastic Surgery, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands. Electronic address:

Purpose: The aim of this study was to analyze the durability of the treatment results of the thumb and first web contractures in Dupuytren disease with collagenase Clostridium histolyticum.

Methods: Twelve patients (14 hands) were followed for an average of 35 months (range, 24-42 months). Two patients (3 hands) were excluded, yielding 11 hands available for assessment. Read More

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November 2018
1 Read

Secondary Effects of Radiation Therapy to the Hand for Benign Conditions.

Hand (N Y) 2018 Nov 12:1558944718810891. Epub 2018 Nov 12.

1 University of Toronto, ON, Canada.

Background: Emerging literature introduces radiation therapy for benign hand conditions. However, hand surgeons are wary recommending radiation therapy for nonmalignant conditions. In our practice, we have used radiation therapy for patients who present with infiltrative or recurrent giant cell tumor of the tendon sheath (GCTTS) since 1998. Read More

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November 2018
1 Read

Impact of mandatory vaccination extension on infant vaccine coverages: Promising preliminary results.

Med Mal Infect 2018 Nov 5. Epub 2018 Nov 5.

Santé publique, épidémiologie et qualité des soins, EA 2694, université Lille, CHU Lille, 59000 Lille, France.

Objective: In France infant vaccines protecting against 11 diseases have changed from a recommended to a mandatory status for all children born on or after January 1, 2018. Using the Vaccinoscopie survey, we measured the impact of this new vaccination policy on vaccine coverage rates (VCRs) and on mothers' perception of vaccination.

Methods: Online survey with 1000 mothers of 0- to 11-month-old infants. Read More

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November 2018
4 Reads

2018 Practice guidelines for the management of arterial hypertension of the European Society of Hypertension (ESH) and the European Society of Cardiology (ESC).

Blood Press 2018 12;27(6):314-340

ac CHU de Limoges , Limoges , France.

These practice guidelines on the management of arterial hypertension are a concise summary of the more extensive ones prepared by the Task Force jointly appointed by the European Society of Hypertension and the European Society of Cardiology. These guidelines have been prepared on the basis of the best available evidence on all issues deserving recommendations; their role must be educational and not prescriptive or coercive for the management of individual subjects who may differ widely in their personal, medical and cultural characteristics. The members of the Task Force have participated independently in the preparation of these guidelines, drawing on their academic and clinical experience and by objective examination and interpretation of all available literature. Read More

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December 2018
9 Reads

Examiners' influence on the measured active and passive extension deficit in finger joints affected by Dupuytren disease.

BMC Med Res Methodol 2018 Oct 29;18(1):120. Epub 2018 Oct 29.

Department of Orthopedics, Kristianstad-Ystad-Hässleholm Hospitals, Hässleholm, Sweden.

Background: The most commonly reported outcome measure in Dupuytren disease is the extension deficit in finger joints. This study aimed to investigate the examiners' influence on the measured difference between active and passive extension deficit.

Methods: A prospective cohort study was conducted on 157 consecutive patients (81% men, mean age 70 years) scheduled for collagenase treatment for Dupuytren disease. Read More

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October 2018
1 Read

Cardiovascular failure and weaning.

Authors:
Philippe Vignon

Ann Transl Med 2018 Sep;6(18):354

Medical-Surgical Intensive Care Unit, Dupuytren Teaching Hospital, Limoges, France.

Cardiac patients are at high risk of weaning failure due to the abrupt burden to the cardiovascular system resulting from the transition from positive-pressure ventilation to spontaneous breathing. Similarly, numerous patients with borderline cardiac function, left ventricular diastolic dysfunction, chronic obstructive pulmonary disease, especially with associated fluid overload or cumulative positive fluid balance, are at high risk of weaning failure of cardiac origin. The diagnosis of weaning-induced pulmonary oedema (WiPO) relies on the measurement of elevated left ventricular filling pressure, or on the presence of a surrogate reflecting pulmonary or cardiac congestion. Read More

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September 2018
1 Read

Emotional feeling in patients suffering from amyotrophic lateral sclerosis.

Geriatr Psychol Neuropsychiatr Vieil 2018 Oct 23. Epub 2018 Oct 23.

Département de neurologie, Centre référent SLA, AP-HP, Hôpital Pitié-Salpêtrière, Paris, France, CNRS, Inserm, Laboratoire d'imagerie biomédicale (LIB), CIC-1422, Sorbonne Universités, UPMC Université Paris 06, Paris, France.

Objective: Amyotrophic lateral sclerosis (ALS) is a fatal and progressive neurodegenerative disorder involving motor neurons of the cerebral cortex, brain stem and spinal cord. Besides the motor signs, cognitive disorders and apathy may be present and may impact the survival time. These elements are therefore to be taken into consideration for medical care because they can influence the disease evolution. Read More

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October 2018
14 Reads

Endoscopic ultrasound-guided choledochoduodenostomy with electrocautery-enhanced lumen-apposing stents: a retrospective analysis.

Endoscopy 2018 Oct 22. Epub 2018 Oct 22.

Service d'Hépato-gastro-entérologie, Hopital Privé Jean Mermoz, Lyon, Farnce.

Background:  Endoscopic ultrasound-guided biliary drainage is an alternative to percutaneous biliary drainage in cases of malignant biliary obstruction and failure of classic endoscopic drainage by endoscopic retrograde cholangiopancreatography (ERCP). Recently, a new electrocautery-enhanced lumen-apposing metal stent (ECE-LAMS) that allows for endoscopic anastomosis (apposition stent) has become available for use in EUS-choledochoduodenostomy (EUS-CDS) and facilitates the procedure.

Methods:  This was a retrospective study of all EUS-CDS procedures performed in France between April 2016 and August 2017. Read More

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October 2018
8 Reads

Safety and tolerability of a single administration of AR-301, a human monoclonal antibody, in ICU patients with severe pneumonia caused by Staphylococcus aureus: first-in-human trial.

Intensive Care Med 2018 Nov 21;44(11):1787-1796. Epub 2018 Oct 21.

Service des Soins Intensifs, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, Brussels, Belgium.

Purpose: Hospital-acquired bacterial pneumonia (HABP) is a critical concern in hospitals with ventilator-associated bacterial pneumonia (VABP) remaining the most common infection in the ICU, often due to Staphylococcus aureus, an increasingly difficult to treat pathogen. Anti-infective monoclonal antibodies (mAb) may provide new, promising treatment options. This randomized, double-blinded, placebo-controlled study aimed at assessing the safety and pharmacokinetics of AR-301, an S. Read More

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November 2018
1 Read

Immature Granulocytes: A Risk Factor of Infection after Cardiac Surgery.

Cytometry B Clin Cytom 2018 Nov 16;94(6):887-894. Epub 2018 Oct 16.

Inserm CIC1435, Dupuytren Teaching Hospital, Limoges, France.

Background: Similarly, to sepsis, cardiac surgery with cardiopulmonary bypass (CPB) induces major changes in leukocyte subsets. Immature granulocytes (IGs) increase both in sepsis and after open-heart surgery. Secondary infections are a major complication of cardiac surgery with CPB. Read More

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November 2018
1 Read

Factors influencing the use of biologic therapy and adoption of treat-to-target recommendations in current European rheumatology practice.

Patient Prefer Adherence 2018 4;12:2007-2014. Epub 2018 Oct 4.

Patient and Health Impact, Pfizer Italia Srl, Rome, Italy.

Objective: The aim of this study was to identify factors that influence treatment adjustments and adoption of a treat-to-target (T2T) strategy in patients with rheumatoid arthritis (RA) in European practices.

Methods: Cross-sectional data were drawn from the Adelphi 2014 RA Disease Specific Programme. Treatment patterns and clinical characteristics were investigated in patients treated with biologic disease-modifying antirheumatic drugs (bDMARDs) vs non-bDMARDs. Read More

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October 2018
2 Reads

Current concepts about treatment options of plantar fibromatosis: A systematic review of the literature.

Foot Ankle Surg 2018 Jun 11. Epub 2018 Jun 11.

Rizzoli Orthopaedic Institute, Bologna, Italy.

Background: Plantar fibromatosis, or Ledderhose disease, is a benign and hyperproliferative disease of the plantar aponeurosis. There have been described different therapeutic options regarding plantar fibromatosis, both conservative and surgical. The aim of this review is to systematically analyze conservative and operative treatments of plantar fibromatosis described in literature, evaluating which procedure shows the highest success rate and best functional outcome. Read More

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June 2018
40 Reads

Familial breast cancer and DNA repair genes: Insights into known and novel susceptibility genes from the GENESIS study, and implications for multigene panel testing.

Int J Cancer 2018 Oct 10. Epub 2018 Oct 10.

Inserm, Paris, France.

Pathogenic variants in BRCA1 and BRCA2 only explain the underlying genetic cause of about 10% of hereditary breast and ovarian cancer families. Because of cost-effectiveness, multigene panel testing is often performed even if the clinical utility of testing most of the genes remains questionable. The purpose of our study was to assess the contribution of rare, deleterious-predicted variants in DNA repair genes in familial breast cancer (BC) in a well-characterized and homogeneous population. Read More

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October 2018
8 Reads

SAFE study (Safety and efficacy Analysis of FRED Embolic device in aneurysm treatment): 1-year clinical and anatomical results.

J Neurointerv Surg 2018 Oct 8. Epub 2018 Oct 8.

Hôpital Gui de Chauliac, Université de Montpellier, Montpellier, France.

Background And Purpose: Flow diversion is an innovative and increasingly used endovascular treatment for intracranial aneurysms. Its initial evaluation with the first devices available showed good efficacy of this treatment with variable safety results. The Flow Direction Endoluminal Device (FRED) has a specific design and was evaluated in a single-arm, multicenter, prospective, Good Clinical Practice study: SAFE (Safety and efficacy Analysis of FRED Embolic device in aneurysm treatment). Read More

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October 2018
2 Reads

Outcomes of Patients With Asymptomatic Aortic Stenosis Followed Up in Heart Valve Clinics.

JAMA Cardiol 2018 Nov;3(11):1060-1068

GIGA Cardiovascular Sciences, Department of Cardiology, Heart Valve Clinic, University of Liège Hospital, Centre Hospitalier Universitaire du Sart Tilman, Liège, Belgium.

Importance: The natural history and the management of patients with asymptomatic aortic stenosis (AS) have not been fully examined in the current era.

Objective: To determine the clinical outcomes of patients with asymptomatic AS using data from the Heart Valve Clinic International Database.

Design, Setting, And Participants: This registry was assembled by merging data from prospectively gathered institutional databases from 10 heart valve clinics in Europe, Canada, and the United States. Read More

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November 2018
2 Reads

Cost Comparison of Collagenase Clostridium Histolyticum and Fasciectomy for Treatment of Dupuytren's Contracture in the Australian Health System.

J Hand Surg Asian Pac Vol 2018 Sep;23(3):336-341

* Department of Hand Surgery and Peripheral Nerve Surgery, Royal North Shore Hospital, Sydney Medical School, University of Sydney, Sydney, Australia.

Background: Dupuytren's disease results in contracted cords in the hand that lead to deformity and disability. Current treatment options include fasciectomy and an injectable, collagenase clostridium histolyticum. No cost comparison studies have been published within the Australian health care environment. Read More

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September 2018
1 Read

Collagenase Clostridium Histolyticum Injection with Precise Needle Length Adjusted by Silicone Tube Interposition for Dupuytren Contracture.

J Hand Surg Asian Pac Vol 2018 Sep;23(3):437-439

* Department of Orthopedic Surgery, Kobe Rosai Hospital, Kobe, Japan.

We describe our injection method for Collagenase Clostridium Histolyticum using a medical silicone tube after determining the optimal depth by ultrasonography. This procedure adjusts the exposed needle length to the planned injection depth by placing a sterilized silicone tube over the needle. The restricted depth provides not only precise injection into the middle of the cords but also avoids needle tip migration through the cord and into the vital structures, which prevents possible complications. Read More

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September 2018
2 Reads

Kaposi sarcoma in HIV-positive solid organ transplant recipients: A French multicentric national study and literature review.

Transplantation 2018 Oct 16. Epub 2018 Oct 16.

APHP Department of Dermatology, Saint Louis Hospital, Paris.

Background: Kaposi sarcoma is a vascular tumor related to herpesvirus-8 and is promoted by immunosuppression. For the last 15 years, HIV patients have had access to organ transplantation. The dual immunosuppression of HIV and immunosuppressive treatments might increase the risk and severity of Kaposi sarcoma. Read More

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October 2018
7 Reads
3.830 Impact Factor

Insight in Information Provision Prior to Obtaining Surgical Informed Consent-by Audiotaping Outpatient Consultations.

World J Surg 2018 Sep 28. Epub 2018 Sep 28.

Department of Plastic Surgery, University of Groningen & University Medical Center Groningen, Hanzeplein 1, 9713 GZ, Groningen, The Netherlands.

Background: Literature suggests that patient-informing process prior to obtaining surgical informed consent (SIC) does not function well. This study aimed to provide insight into the current practice of SIC in the Netherlands.

Methods: This is a prospective, observational, and multicenter study, conducted in one academic and two non-academic teaching hospitals in the Netherlands. Read More

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September 2018
4 Reads

Implantable venous access device placement (IVAD) using the cephalic vein (with video).

J Visc Surg 2018 Sep 24. Epub 2018 Sep 24.

Chirurgie digestive, générale et endocrinienne, hôpital Dupuytren, CHU de Limoges, 87042 Limoges cedex, France.

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September 2018
4 Reads

Range of motion, postoperative rehabilitation and patient satisfaction in MCP and PIP joints affected by Dupuytren Tubiana stage 1-3: collagenase enzymatic fasciotomy or limited fasciectomy? A clinical study in 52 patients.

Arch Orthop Trauma Surg 2018 Nov 26;138(11):1623-1631. Epub 2018 Sep 26.

Department of Plastic- und Hand Surgery, Bern University Hospital, Inselspital, University of Bern, Freiburgstrasse, 3010, Bern, Switzerland.

Introduction: In Switzerland, collagenase Clostridium histolyticum therapy (CCH) for Dupuytren's disease was introduced in 2011. This study analyzes possible differences between CCH and limited fasciectomy (LF) in terms of range of motion, patient satisfaction and postoperative rehabilitation.

Materials And Methods: This retrospective study included 52 patients with Dupuytren's disease stage 1-3 according to Tubiana, treated with CCH or LF between January 2012 and December 2013. Read More

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November 2018
3 Reads

Adverse effects associated with collagenase clostridium histolyticum in Dupuytren disease: A prospective study.

Orthop Traumatol Surg Res 2018 Oct 2;104(6):901-905. Epub 2018 Jul 2.

University of Granada, Spain; Ophtalmologic Department, Hospital Virxen da Xunqueira, Cee, 15270 A Coruña, Spain.

Background: Collagenase clostridium histolyticum is now recognized as a viable treatment for Dupuytren disease. The high rate of adverse effects reported in patients continues to spark debate and raise questions about the true frequency of effects and their associated mechanisms of action.

Hypothesis: To investigate whether outcomes of CCH treatment are related to the number of adverse effects experienced. Read More

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October 2018
3 Reads

Distal sensory disorders in Dupuytren's disease.

Orthop Traumatol Surg Res 2018 Oct 6;104(6):897-900. Epub 2018 Jul 6.

Hand, upper extremity and peripheral nerve surgery service, European Hospital Georges-Pompidou (HEGP, 75015 Paris), AP-HP, université Paris-Descartes, 20, rue Leblanc, Sorbonne Paris Cite, 75015 Paris, France(1).

Purpose: Dupuytren's disease is a common and disabling condition. Its pathophysiology is not well understood. Some patients complain of postoperative loss of fingertip sensitivity that could be due either to the surgery or to the disease itself. Read More

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October 2018

Comparison of echocardiographic parameters in Fabry cardiomyopathy and light-chain cardiac amyloidosis.

Echocardiography 2018 11 24;35(11):1755-1763. Epub 2018 Sep 24.

Department of Cardiology, Dupuytren University Hospital, Limoges, France.

Background: Fabry cardiomyopathy (FC) and light-chain amyloid cardiomyopathy (AL) present with concentric left ventricular (LV) hypertrophy/remodeling and diastolic rather than systolic dysfunction. Direct comparisons are difficult due to rarity and confounded by variability of LV thickness.

Aims: To compare LV diastolic and systolic properties between patients with FC and AL in a cohort matched for interventricular septal thickness (IVS). Read More

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November 2018
10 Reads

Focus on echovascular imaging assessment of arterial disease: complement to the ESC guidelines (PARTIM 1) in collaboration with the Working Group on Aorta and Peripheral Vascular Diseases.

Eur Heart J Cardiovasc Imaging 2018 Nov;19(11):1195-1221

Department of Cardiology, University of Liege Hospital, GIGA Cardiovascular Sciences, B35, Avenue de l'Hôpital, 1, Liege, Belgium.

The main goal of the present document is to provide a set of practical recommendations for ultrasound imagers who are interested in artery diseases or for physicians who intend to undertake vascular procedures. This is the first part of the work. It is dedicated to general principles of ultrasonography, cervicoencephalic, subclavian, aortoiliac and lower extremity arteries, abdominal aorta, and popliteal aneurysms. Read More

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November 2018
1 Read

Hyperspectral imaging as a possible tool for visualization of changes in hemoglobin oxygenation in patients with deficient hemodynamics - proof of concept.

Biomed Tech (Berl) 2018 Oct;63(5):609-616

Department of Dermatology, University Medicine Greifswald, Greifswald, Germany.

There is a lack of imaging tools for the evaluation of spatial alterations in microcirculation including blood oxygen saturation and hemoglobin distribution but recent innovative developments in hyperspectral technology may offer a solution. We examined different hemodynamic disorders in patients suffering from scleroderma, Dupuytren surgery, chronic foot ulcera and skin infections. Superficial and deeper blood oxygen saturation, hemoglobin distribution and water content were determined using hyperspectral imaging (HSI). Read More

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October 2018
1 Read

Preemptive rituximab prevents long-term relapses in immune-mediated thrombotic thrombocytopenic purpura.

Blood 2018 Nov 10;132(20):2143-2153. Epub 2018 Sep 10.

Centre de Référence des Microangiopathies Thrombotiques, Hôpital Saint-Antoine, Assistance Publique-Hôpitaux de Paris, Paris, France.

Preemptive rituximab infusions prevent relapses in immune thrombotic thrombocytopenic purpura (iTTP) by maintaining normal ADAMTS13 activity. However, the long-term outcome of these patients and the potential adverse events of this strategy need to be determined. We report the long-term outcome of 92 patients with iTTP in clinical remission who received preemptive rituximab after identification of severe ADAMTS13 deficiency (activity <10%) during the follow-up. Read More

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November 2018
1 Read
10.450 Impact Factor

Six Degrees of Separation: A Journey through Joint and Personal Connections.

Authors:
Robert J Spinner

Clin Anat 2018 Sep 10. Epub 2018 Sep 10.

Departments of Neurologic Surgery and Orthopedics, Mayo Clinic, Rochester, MN, 55905, USA.

My research on intraneural ganglion cysts has led me on a journey through history to discover a Six Degrees of Separation network, linking my interest in joint connections (of nerve) with personal interconnections. This research took me on an exciting personal journey through the history of neurology, anatomy, and hand and peripheral nerve surgery in Paris, France and New York City. Following famous footsteps like breadcrumbs, my Six Degrees of Separation to Duchenne de Boulogne and Edme François Chauvot de Beauchêne (Beauchêne fils) could be traced through personal connections with leaders including Baron Guillaume Dupuytren, Emanuel Kaplan, J. Read More

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September 2018
1 Read

Updated strategies in the treatment of benign diseases-a patterns of care study of the german cooperative group on benign diseases.

Adv Radiat Oncol 2018 Jul-Sep;3(3):240-244. Epub 2018 Feb 26.

Department of Radiation Oncology, University of Muenster, Muenster, Germany.

Purpose: Radiation therapy (RT) is a common treatment for benign diseases in Germany. Because the treatment concepts are inconsistent, we conducted this pattern-of-care study on behalf of the German Cooperative Group on Benign Diseases to evaluate treatment standards in Germany.

Methods And Materials: Questionnaires were mailed to all radiation therapy facilities in Germany. Read More

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February 2018
12 Reads

Bipolar transfer of the pectoralis major muscle for restoration of elbow flexion in 29 cases.

J Shoulder Elbow Surg 2018 Nov 6;27(11):e330-e336. Epub 2018 Sep 6.

Clinique du Mont Louis, Paris, France.

Background: This study evaluated the functional outcomes of bipolar pedicled pectoralis major (PM) transfer to restore elbow flexion.

Methods: We retrospectively reviewed 29 transfers in 28 patients with a mean age of 31.2 years (range, 5-65 years). Read More

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November 2018
2 Reads

A physician's hand tumour induced by the first X-ray procedures.

Lancet Oncol 2018 Sep;19(9):1158

Department of Health Sciences and Section of Medical and Forensic Anthropology University of Versailles Saint-Quentin, Montigny-Le-Bretonneux, France; CASH & IPES, Nanterre, France.

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September 2018
7 Reads

Low rates of recanalization for wide-necked aneurysms treated with stenting after balloon-assisted coiling: combination of techniques delivers stable and improved results during follow-up.

Neuroradiology 2018 Nov 5;60(11):1223-1230. Epub 2018 Sep 5.

Department of Neuroradiology, Alfried-Krupp Krankenhaus Hospital, Alfried-Krupp Straße 21, 45131, Essen, Germany.

Purpose: In the treatment of wide-necked aneurysms, stenting may be required after balloon-assisted coiling (BAC) for reconstructing the lumen/flow of the parent artery in cases of coil herniation. The potential benefits and complications of both techniques remain unclear when used together. Our aim was to assess the safety and long-term angiographic outcomes of stenting after BAC. Read More

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November 2018
6 Reads

Hepatitis B Virus Blocks the CRE/CREB Complex and Prevents TLR9 Transcription and Function in Human B Cells.

J Immunol 2018 Oct 5;201(8):2331-2344. Epub 2018 Sep 5.

Centre International de Recherche en Infectiologie, INSERM, U1111, 69007 Lyon, France;

Effective B cell responses such as cytokine secretion, proliferation, and Ab-specific responses are essential to clear hepatitis B virus (HBV) infection. However, HBV alters numerous immune pathways to persist in the host. B cell activity depends on activation of the innate sensor TLR9 by viral or bacterial DNA motifs. Read More

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October 2018
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