2,762 results match your criteria Dupuytren Contracture


[Non-surgical treatment of Dupuytren's disease by using percutaneous needle aponeurotomy: A 10-year experience].

Rehabilitacion (Madr) 2020 May 3. Epub 2020 May 3.

Servicio de Reumatología, Centro Hospitalar São João, Porto, Portugal.

Introduction: Dupuytren's disease is a fibroproliferative disorder of the palmar aponeurosis that leads to digital flexion contractures. This disabling condition can be treated with a minimally invasive procedure, called percutaneous needle aponeurotomy (PNA).

Objective: To report the results of 10 years of experience treating Dupuytren's contracture by PNA in the rheumatology hand unit of our department. Read More

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http://dx.doi.org/10.1016/j.rh.2020.02.007DOI Listing

Dupuytren's disease: A reality in Black Africa.

Hand Surg Rehabil 2020 May 4. Epub 2020 May 4.

Department of Orthopedics Traumatology, CHU Le Dantec, BP 5994, Dakar-Fann, Senegal.

Long regarded as a disease exclusively found amongst Northern Europeans, Dupuytren's disease was seldom studied amongst Black Africans. Thus, we sought to study the impact of Dupuytren's disease, its etiological, clinical and evolutionary peculiarities on a segment of the Senegalese population. This study analyzed data derived from clinical observations carried out between January 2006 and December 2018. Read More

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http://dx.doi.org/10.1016/j.hansur.2020.04.005DOI Listing

Reliability and Interpretability of Sonographic Measurements of Palmar Dupuytren Nodules.

J Hand Surg Am 2020 Mar 14. Epub 2020 Mar 14.

Department of Plastic Surgery, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

Purpose: In the future, it is expected that treatment of Dupuytren disease (DD) may shift toward control of early disease. Ultrasound might be an accurate method to measure the outcome of such treatment. The aim of this study was to assess the reliability of sonographic measurement of palmar nodules. Read More

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http://dx.doi.org/10.1016/j.jhsa.2020.01.005DOI Listing

Percutaneous needle fasciotomy in Dupuytren contracture: a register-based, observational cohort study on complications in 3,331 treated fingers in 2,257 patients.

Acta Orthop 2020 Feb 14:1-5. Epub 2020 Feb 14.

Department of Orthopaedic Surgery, Horsens Regional Hospital, Denmark.

Background and purpose - Percutaneous needle fasciotomy (PNF) is a minimally invasive treatment option for Dupuytren contracture, which has gained momentum worldwide in recent years. However, evidence regarding safety and severe complications associated with PNF is sparse. Thus, we evaluated safety of a specific PNF method in the largest cohort reported in literature. Read More

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http://dx.doi.org/10.1080/17453674.2020.1726057DOI Listing
February 2020

Effects of electromechanical reshaping on mechanical behavior of exvivo bovine tendon.

Clin Biomech (Bristol, Avon) 2020 Mar 15;73:92-100. Epub 2020 Jan 15.

Beckman Laser Institute, University of California, Irvine, CA, USA; Department of Otolaryngology, Head and Neck Surgery, University of California, Irvine, Orange, CA, USA; Department of Biomedical Engineering, University of California, Irvine, Irvine, CA, USA. Electronic address:

Background: Electromechanical reshaping is a novel, minimally invasive means to induce mechanical changes in connective tissues, and has the potential to be utilized in lieu of current orthopedic therapies that involve tendons and ligaments. Electromechanical reshaping delivers an electrical current to tissues while under mechanical deformation, causing in situ redox changes that produce reliably controlled and spatially limited mechanical and structural changes. In this study, we examine the feasibility of altering Young's modulus and inducing a shape deformation using an ex vivo bovine Achilles tendon model. Read More

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http://dx.doi.org/10.1016/j.clinbiomech.2020.01.009DOI Listing

Long-term Effects of Skin Tearing on Outcomes After Collagenase Treatment of Dupuytren Contractures.

Hand (N Y) 2020 Jan 15:1558944719898836. Epub 2020 Jan 15.

Brigham and Women's Hospital, Boston, MA, USA.

The objective of this study was to compare the rates of recurrence, additional treatment, patient satisfaction, and willingness to undergo (CCH) treatment again for Dupuytren disease in patients with and without skin tearing at minimum 5-year follow-up. We identified 199 digits in 142 patients who underwent CCH treatments for Dupuytren disease from April 2010 to December 2013 with minimum 5-year follow-up. Patients were contacted by telephone to collect our response variables: perceived recurrence of contracture, additional treatment, satisfaction, and willingness to undergo CCH treatment again. Read More

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http://dx.doi.org/10.1177/1558944719898836DOI Listing
January 2020

Skin Expansion Due to the Dupuytren Cord Allows to Design Local Flaps to Facilitate Skin Closure in Severe Cases: The 3-flap: Surgical Technique and Clinical Evaluation.

Tech Hand Up Extrem Surg 2020 Jun;24(2):89-97

Chirurgie de la Main, Centre Chirurgical Émile Gallé, Nancy, France.

In the serious forms of Dupuytren disease, passive extension during surgery often results in unmasking a loss of skin substance that makes primary closure impossible. Our objective in this study was to describe and assess the therapeutic possibilities of a 3 local flaps surgical approach in serious forms of Dupuytren disease, using the lateral skin expansion because of the cord. A cadaveric study was carried out on 12 adult nonembalmed, fresh frozen hands. Read More

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http://dx.doi.org/10.1097/BTH.0000000000000271DOI Listing

Comments on the manuscript of Dr. J M Orenstein.

Authors:
Giulio Gabbiani

Ultrastruct Pathol 2020 01 25;44(1):15-16. Epub 2019 Dec 25.

Department of Pathology and Immunology, University of Geneva, Geneva, Switzerland.

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http://dx.doi.org/10.1080/01913123.2019.1704525DOI Listing
January 2020

Dupuytren contracture as a sign of systemic disease.

Clin Dermatol 2019 Nov - Dec;37(6):675-678. Epub 2019 Jul 31.

The London Clinic, London, England.

Dupuytren contracture (DC) is predominantly an autosomal dominant disorder characterized by hypertrophy and contraction of the palmar fascia that results in tethered flexion of the affected digits. It has its highest prevalence in the North European population or in people of Viking descent, and its incidence is growing with age. DC shares a common inheritance mode, predisposing factors, comorbidities, pathophysiology, and evolution with Ledderhose disease, Garrod knuckle pads, and Peyronie disease. Read More

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http://dx.doi.org/10.1016/j.clindermatol.2019.07.027DOI Listing

Illness Perceptions of Patients With First Carpometacarpal Osteoarthritis, Carpal Tunnel Syndrome, Dupuytren Contracture, or Trigger Finger.

J Hand Surg Am 2020 May 5;45(5):455.e1-455.e8. Epub 2019 Dec 5.

Department of Plastic, Reconstructive and Hand Surgery, Erasmus MC, Rotterdam, The Netherlands; Department of Rehabilitation Medicine, Erasmus MC, Rotterdam, The Netherlands; Hand and Wrist Center, Xpert Clinic, Amsterdam, The Netherlands; Integrated Brain Health Clinical and Research Program, Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA.

Purpose: Previous studies indicate that patients with a more negative perception of their illness tend to respond less favorably to treatment, but little is known about whether illness perceptions differ based on the type of hand or wrist conditions. Therefore, we compared illness perceptions between patients scheduled to undergo surgery for 4 illnesses in hand surgery: carpometacarpal osteoarthritis (CMC OA), Dupuytren disease, carpal tunnel syndrome (CTS), and trigger finger syndrome (TFS). We hypothesized there would be differences in illness perception between these patient groups. Read More

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http://dx.doi.org/10.1016/j.jhsa.2019.10.021DOI Listing

Patient's satisfaction beyond hand function in Dupuytren's disease: analysis of 1106 patients.

J Hand Surg Eur Vol 2020 Mar 28;45(3):280-285. Epub 2019 Nov 28.

Department of Plastic, Reconstructive and Hand Surgery, University Medical Center Rotterdam, Rotterdam, The Netherlands.

This study investigates the outcomes of 1106 patients with Dupuytren's disease treated with limited fasciectomy or percutaneous needle fasciotomy over 16 years according to the different domains of patient-reported hand function. These patients completed the Michigan Hand Outcomes Questionnaire before and 3 months after surgery. Scores for the various outcome parameters were calculated and linear regression analyses were used to examine associations between the changes in digital extension deficit and change in Michigan Hand Outcomes Questionnaire (sub)scores. Read More

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http://dx.doi.org/10.1177/1753193419890284DOI Listing

Needle fasciotomy for Dupuytren's contracture- a prospective cohort study of 58 fingers with a median follow-up of 6.5 years.

J Plast Surg Hand Surg 2020 Apr 22;54(2):89-93. Epub 2019 Nov 22.

Department of Hand Surgery, Sahlgrenska University Hospital, Gothenburg, Sweden.

Needle fasciotomy (NF) is a minimally invasive treatment option for Dupuytren contractures, but long-term results have indicated a high recurrence rate. This prospective study was initiated to monitor the introduction of NF in a context where limited fasciectomy had been the only treatment option, and to investigate the long-term results. The inclusion criterion was a palpable cord with a Metacarpophalangeal (MCP) and/or Proximal interphalangeal (PIP) contracture in one or more fingers. Read More

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http://dx.doi.org/10.1080/2000656X.2019.1693391DOI Listing

Radiation Therapy for Benign Disease: Arteriovenous Malformations, Desmoid Tumor, Dupuytren Contracture, Graves Ophthalmopathy, Gynecomastia, Heterotopic Ossification, Histiocytosis.

Hematol Oncol Clin North Am 2020 Feb 28;34(1):205-227. Epub 2019 Oct 28.

Radiation Oncology Department, Winship Cancer Institute of Emory University, 1365 Clifton Road Northeast, Building C, Atlanta, GA 30322, USA.

Although the use of ionizing radiation in malignant conditions has been well established, its application in benign conditions has not been fully accepted and has been inadequately recognized by health care providers outside of radiation therapy. Most frequently, radiation therapy in these benign conditions is used along with other treatment modalities, such as surgery, in instances where the condition causes significant disability or could even lead to death. Radiation therapy can be helpful for inflammatory/proliferative disorders. Read More

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http://dx.doi.org/10.1016/j.hoc.2019.09.005DOI Listing
February 2020

Using Tongue Depressors as a Technique to Aid Cord Localization During Collagenase Injection For Dupuytren Disease.

Tech Hand Up Extrem Surg 2019 Dec;23(4):196-198

Department of Orthopedic Surgery and Sports Medicine, University of Kentucky.

Collagenase injections are used as a minimally invasive treatment for Dupuytren contracture of the palm and fingers, with good published success. Most complications are related to injection-site swelling, pain, and ecchymosis. However, the risk of flexor tendon and digital nerve injury can occur when injecting cords that cause proximal interphalangeal joint contractures. Read More

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http://dx.doi.org/10.1097/BTH.0000000000000254DOI Listing
December 2019

[Distal-type Cervical Spondylolisthesis Muscular Atrophy in a Patient with Dupuytren Contracture: A Case Report].

Brain Nerve 2019 Nov;71(11):1303-1307

Department of Neurology, Gifu University Graduate School of Medicine.

We report the case of a 71-year-old man with impaired left finger extension. The presence of nodular fibrosing lesions in his palm suggested Dupuytren contracture as the diagnosis. However, detailed neurological examination revealed muscle weakness associated with C7-Th1 lesions, and needle electromyography revealed denervation within the same distribution. Read More

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http://dx.doi.org/10.11477/mf.1416201440DOI Listing
November 2019

Current role of the collagenase Clostridium histolyticum in Dupuytren's disease treatment.

Ir J Med Sci 2020 May 11;189(2):529-534. Epub 2019 Nov 11.

Orthopedic and Trauma Department, Hospital de Denia, Partida Beniadla s/n, 03700, Alicante, Denia, Spain.

Background: Collagenase Clostridium histolyticum (CCH) is a recent treatment for Dupuytren disease, which is a fibroproliferative disorder that leads to progressive, persistent digital flexion contracture that interferes with basic daily activities. While CCH has changed the treatment of this hand disorder, numerous concerns have to be analyzed.

Aims: Our purpose is to assess the current status of this medical treatment. Read More

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http://dx.doi.org/10.1007/s11845-019-02127-zDOI Listing
May 2020
6 Reads

The Effects of Collagenase Clostridium histolyticum on Plantar Fibromatosis: A Case Study.

J Foot Ankle Surg 2019 Nov;58(6):1281-1284

Pathologist, Crozer Keystone Health System, Upland, PA.

Plantar fibromatosis, also known as Ledderhose's disease, is a rare disorder of benign fibroblast proliferation involving the plantar aponeurosis (i.e., plantar fascia). Read More

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http://dx.doi.org/10.1053/j.jfas.2019.04.006DOI Listing
November 2019

Segmental aponeurectomy with Z-Plasty as a treatment option in Dupuytren's disease: A retrospective cohort study.

Orthop Traumatol Surg Res 2019 12 29;105(8):1627-1631. Epub 2019 Oct 29.

Service de chirurgie plastique et de la main, CHU de Rouen, 1, rue de Germont, 76031 Rouen cedex, France.

Background: Aponeurectomy remains the reference standard treatment for digit tethering by palmar fascial cords in Dupuytren's disease but is associated with a substantial complication rate. An alternative technique decreases metacarpophalangeal joint (MCPJ) flexion contracture by combining palmar segmental aponeurectomy with Z-plasty skin closure. The primary objective of this study was to assess range of motion of the operated ray after the procedure. Read More

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http://dx.doi.org/10.1016/j.otsr.2019.08.016DOI Listing
December 2019

Outcomes and Direct Costs of Needle Aponeurotomy, Collagenase Injection, and Fasciectomy in the Treatment of Dupuytren Contracture.

J Hand Surg Am 2019 Nov 17;44(11):919-927. Epub 2019 Sep 17.

Department of Orthopedic Surgery, Rochester, MN. Electronic address:

Purpose: The aims of our study were to evaluate the rates and predictors of reinterventions and direct costs of 3 common treatments of Dupuytren contractures-needle aponeurotomy, collagenase injection, and surgical fasciectomy.

Methods: A retrospective review identified 848 interventions for Dupuytren contracture in 350 patients treated by a single surgeon from 2005 to 2016. The treatments included needle aponeurotomy (NA) (n = 444), collagenase injection (n = 272), and open fasciectomy (n = 132). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03635023183149
Publisher Site
http://dx.doi.org/10.1016/j.jhsa.2019.07.017DOI Listing
November 2019
3 Reads

Collagenase injections for Dupuytren disease: 3-year treatment outcomes and predictors of recurrence in 89 hands.

Acta Orthop 2019 12 10;90(6):517-522. Epub 2019 Sep 10.

Department of Orthopedics, Hässleholm-Kristianstad Hospitals, Hässleholm.

Background and purpose - Few prospective studies have reported the long-term effect durability of collagenase injections for Dupuytren disease. We assessed the 3-year treatment outcome of collagenase injections and predictors of recurrence.Patients and methods - We conducted a single-center prospective cohort study. Read More

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http://dx.doi.org/10.1080/17453674.2019.1663472DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6844429PMC
December 2019
1 Read

Dupuytren, Ledderhose, and Peyronie Diseases After Primidone Use For Essential Tremor.

Neurologist 2019 Sep;24(5):150-151

Department of Neurology, Federal Hospital of Servidores do Estado, Rio de Janeiro-RJ, Brazil.

Introduction: Dupuytren, Ledderhose, and Peyronie diseases are chronic fibrotic conditions related to progressive fibrosis of the palmar fascia, plantar fascia, and tunica albuginea, respectively. These conditions have been associated with antiepileptic drug use, mainly phenobarbital and primidone.

Case Report: A 71-year-old man developed simultaneous Dupuytren, Ledderhose, and Peyronie diseases after primidone use for essential tremor. Read More

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http://dx.doi.org/10.1097/NRL.0000000000000240DOI Listing
September 2019

Experiences of men living with Dupuytren's disease-Consequences of the disease for hand function and daily activities.

J Hand Ther 2019 Aug 30. Epub 2019 Aug 30.

Division of Health Care Analysis, Department of Medical and Health Sciences, Linköping University, Linköping, Sweden.

Study Design: Qualitative descriptive.

Introduction: Dupuytren's disease (DD) is a chronic hand condition causing impairment in hand function. Research describing persons' experiences of living with DD is limited. Read More

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http://dx.doi.org/10.1016/j.jht.2019.04.004DOI Listing
August 2019
2 Reads

Collagenase Clostridium Histolyticum Injection for Dupuytren Contracture: 2-Year Follow-up.

Clin Orthop Surg 2019 Sep 12;11(3):332-336. Epub 2019 Aug 12.

Department of Orthopaedic Surgery, Johns Hopkins University, Baltimore, MD, USA.

Background: Dupuytren disease is characterized by the development of palmar fibrous tissue that can lead to fixed flexion contracture (FFC) and contribute to functional loss of the involved digits. Our goal was to investigate rates of contracture resolution and recurrence in patients who underwent enzymatic fasciotomy for Dupuytren contracture consisting of collagenase clostridium histolyticum (CCH) injection followed by passive manipulation combined with splinting and home-based therapy.

Methods: We prospectively enrolled 34 patients (44 metacarpophalangeal [MCP] and 33 proximal interphalangeal [PIP] joints) treated by one orthopaedic hand surgeon between November 2010 and November 2014. Read More

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http://dx.doi.org/10.4055/cios.2019.11.3.332DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6695332PMC
September 2019
1 Read

Hand therapy or not following collagenase treatment for Dupuytren's contracture? Protocol for a randomised controlled trial.

BMC Musculoskelet Disord 2019 Aug 28;20(1):387. Epub 2019 Aug 28.

Department of Occupational Therapy, Orthopaedic Clinic, Haukeland University Hospital (HUH), Bergen, Norway.

Background: Dupuytren's contracture (DC) is a fibrotic hand condition in which one or more fingers develop progressive flexion deformities. Quality of life is diminished due to disabling limitations in performing everyday activities. For DC patients treated with collagenase, referral for subsequent hand therapy is inconsistent. Read More

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http://dx.doi.org/10.1186/s12891-019-2712-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6712875PMC
August 2019
1 Read

Risk Factors for Skin Tearing in Collagenase Treatment of Dupuytren Contractures.

J Hand Surg Am 2019 Dec 14;44(12):1021-1025. Epub 2019 Aug 14.

Department of Orthopaedic Surgery, Brigham and Women's Hospital, Boston, MA; Harvard Medical School, Boston, MA.

Purpose: To determine factors associated with skin tearing at the time of manipulation in patients undergoing collagenase Clostridium histolyticum (CCH) treatment for Dupuytren contractures.

Methods: We identified 368 digits in 261 patients who underwent a total of 469 CCH treatments at a tertiary care referral center from April, 2010 to December, 2013. Medical records were reviewed for the primary outcome, skin tearing at manipulation. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03635023183162
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http://dx.doi.org/10.1016/j.jhsa.2019.06.010DOI Listing
December 2019
2 Reads

Association between occupational exposure and Dupuytren's contracture using a job-exposure matrix and self-reported exposure in the CONSTANCES cohort.

Occup Environ Med 2019 11 12;76(11):845-848. Epub 2019 Aug 12.

Unité Hospitalo-Universitaire de Santé professionnelle Hôpitaux Universitaires de Paris Ile-de-France Ouest, site Raymond Poincaré, AP-HP, UVSQ, IIMTPIF, Garches, France.

Background: Although several studies highlighted an association between occupational exposure and Dupuytren's contracture (DC), they were often limited by the highly selected population. We aimed to study this association using a job-exposure matrix (JEM) and self-reported exposure in a large cohort.

Methods: From CONSTANCES, a French population-based prospective cohort, we retrieved sex, age, social position, alcohol/tobacco intake and diabetes. Read More

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http://dx.doi.org/10.1136/oemed-2019-105912DOI Listing
November 2019

Outcome of Recurrent Surgery in Dupuytren's Disease: Comparison with Initial Treatment.

Plast Reconstr Surg 2019 11;144(5):828e-835e

Rotterdam, The Netherlands From the Department of Plastic, Reconstructive, and Hand Surgery and the Department of Rehabilitation Medicine, Erasmus University Medical Centre; and the Hand and Wrist Centre, Xpert Clinic.

Background: There are multiple studies about the effectiveness of primary treatment in Dupuytren's disease. However, such studies concerning treatment effectiveness of recurrent disease are scarce. Therefore, the primary aim of this study was to compare treatment effectiveness of initial and repeated surgery in patients with Dupuytren's disease. Read More

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http://dx.doi.org/10.1097/PRS.0000000000006150DOI Listing
November 2019

Using tongue depressors to aid cord localization during collagenase injection for Dupuytren disease.

Hand Surg Rehabil 2019 10 3;38(5):290-292. Epub 2019 Aug 3.

Department of hand surgery, Third Hospital of Hebei Medical University, 139 Ziqiang Rd, Shijiazhuang, Hebei, 050051, China.

The aim of this paper was to introduce a simple and effective method to aid in isolation and stabilization of Dupuytren cords for collagenase injection. Tongue depressors were used to isolate and stabilize the cord during the injection procedure. The area to be injected was sterilely prepared. Read More

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http://dx.doi.org/10.1016/j.hansur.2019.07.006DOI Listing
October 2019
5 Reads

Analysis of recurrence and complications after percutaneous needle fasciotomy in Dupuytren's disease.

Arch Orthop Trauma Surg 2019 Oct 31;139(10):1471-1477. Epub 2019 Jul 31.

Department for Plastic Surgery and Hand Surgery, Klinikum Rechts Der Isar, Technische Universität München, Ismaningerstrasse 22, 81675, Munich, Germany.

Introduction: The partial aponeurectomy for treatment of Dupuytren's contracture represents the gold standard for treatment of Dupuytren's contracture. In selected cases, the alternative is the percutaneous needle fasciotomy (PNF).

Materials And Methods: Between 2008 and 2018, 80 rays in 64 patients were treated using PNF. Read More

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http://dx.doi.org/10.1007/s00402-019-03247-yDOI Listing
October 2019

The Effect of Chitosan Derivatives on the Compaction and Tension Generation of the Fibroblast-populated Collagen Matrix.

Molecules 2019 Jul 26;24(15). Epub 2019 Jul 26.

Center for Interdisciplinary Biomedical Education and Research (CIBER), College of Mathematics and Science, University of Central Oklahoma, 100 N. University Drive, Edmond, OK 73034, USA.

Fibrotic diseases, such as Dupuytren's contracture (DC), involve excess scar tissue formation. The differentiation of fibroblasts into myofibroblasts is a significant mechanism in DC, as it generates tissue contraction in areas without wound openings, leading to the deposition of scar tissue, and eventually flexing one or more fingers in a restrictive fashion. Additionally, DC has a high recurrence rate. Read More

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http://dx.doi.org/10.3390/molecules24152713DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6696429PMC
July 2019
4 Reads

Hand Function Deficiency in Patients with Dupuytren's Disease and Course of Recovery after Palmar Fasciectomy.

Acta Chir Orthop Traumatol Cech 2019 ;86(3):193-198

2nd Department of General Surgery, Jagiellonian University Medical College, Kraków, Poland.

PURPOSE OF THE STUDY To evaluate hand function deficiency in patients with Dupuytren's disease (DD) in addition to assessing the improvement of function after palmar fasciectomy by using different hand-related questionnaires. MATERIAL AND METHODS A total of 121 hands (95 patients) underwent surgery. Disease severity was designated using Tubiana's Staging System. Read More

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November 2019
2 Reads

Predictable fibroblast tension generation by measuring compaction of anchored collagen matrices using microscopy and optical coherence tomography.

Cell Adh Migr 2019 12;13(1):303-314

a Department of Biology, University of Central Oklahoma , Edmond , OK , USA.

The anchored fibroblast-populated collagen matrix (aFPCM) is an appropriate model to study fibrocontractive disease mechanisms. Our goal was to determine if aFPCM height reduction (compaction) during development is sufficient to predict tension generation. Compaction was quantified daily by both traditional light microscopy and an optical coherence tomography (OCT) system. Read More

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http://dx.doi.org/10.1080/19336918.2019.1644855DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6650198PMC
December 2019
2 Reads

Prospective observation of Clostridium histolyticum collagenase for the treatment of Dupuytren's disease in 788 patients: the Austrian register.

Arch Orthop Trauma Surg 2019 Sep 17;139(9):1315-1321. Epub 2019 Jul 17.

Department of Trauma Surgery, Medical University of Innsbruck, Anichstr. 35, 6020, Innsbruck, Austria.

Introduction: Since March 2011, the microbial collagenase of Clostridium histolyticum (Xiapex®, Swedish Orphan Biovitrum AB, Stockholm, Sweden) has become available in the European Union for treatment of Dupuytren's disease. The purpose of this study was to evaluate potential safety risks of Xiapex® and to contribute to a better understanding for its use.

Methods: A prospective, non-interventional, observational study using Xiapex® for Dupuytren's disease named XIANIS was conducted between 1. Read More

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http://dx.doi.org/10.1007/s00402-019-03226-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6689902PMC
September 2019
6 Reads

A new finger-preserving procedure as an alternative to amputation in recurrent severe Dupuytren contracture of the small finger.

BMC Musculoskelet Disord 2019 Jul 9;20(1):323. Epub 2019 Jul 9.

Department of Orthopedics, Hässleholm-Kristianstad Hospitals, SE-28125, Hässleholm, Sweden.

Background: Recurrent severe Dupuytren contracture of the small finger's proximal interphalangeal (PIP) joint is a difficult problem. Further surgery carries high risk of complications and poor outcome. Patients are often offered finger amputation. Read More

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http://dx.doi.org/10.1186/s12891-019-2701-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6617564PMC
July 2019
3 Reads

Bilateral Plantar Fibromatosis

Ir Med J 2019 04 11;112(4):919. Epub 2019 Apr 11.

Mater Misericordiae University Hospital, Eccles Street, Dublin 7

Aim To describe an uncommon clinical finding and raise awareness of its manifestation and associated conditions. Methods This case describes a gentleman with bilateral plantar fibromatosis caused by type 2 Diabetes Mellitus and previous alcohol excess. Results Treatment options include physiotherapy, steroid and collagenase injection therapy. Read More

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April 2019
15 Reads

Dags att sluta med kollagenas vid Dupuytrens kontraktur? - Nålfasciotomi ger lika goda resultat – till en tredjedel av priset.

Lakartidningen 2018 Sep 25;115. Epub 2018 Sep 25.

Sahlgrenska universitetssjukhuset - Goteborg, Sweden - Avancerad rekonstruktion av extremiteter Mölndal, Sweden.

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September 2018
3 Reads

ABC om - Vanliga tillstånd i hand och handled, del 2 - Triggerfinger, Dupuytrens kontraktur och ganglion.

Lakartidningen 2019 May 14;116. Epub 2019 May 14.

Goteborgs universitet Institutionen for kliniska vetenskaper - Goteborg, Sweden Goteborgs universitet Institutionen for kliniska vetenskaper - Goteborg, Sweden.

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May 2019
2 Reads

[Hyperspectral imaging demonstrates microcirculatory effects of postoperative exercise therapy in Dupuytren's disease].

Handchir Mikrochir Plast Chir 2019 Jun 5;51(3):171-176. Epub 2019 Jun 5.

Universitätsmedizin Greifswald, Klinik und Poliklinik für Hautkrankheiten.

Background: Dupuytren's disease (DD) is a common connective tissue disorder of the hand. To prevent recurrence of contractures, patients usually receive early postoperative ergotherapy (ET). However, it is yet unknown how this measure impacts on local blood flow and hence on the occurrence or prevention of postoperative complications. Read More

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http://dx.doi.org/10.1055/a-0916-8635DOI Listing
June 2019
4 Reads

Imaging for Dupuytren disease: a systematic review of the literature.

BMC Musculoskelet Disord 2019 May 17;20(1):224. Epub 2019 May 17.

Department of Plastic surgery, University of Groningen, University Medical Center Groningen, BB81 Hanzeplein 1, 9713 GZ, Groningen, The Netherlands.

Background: As treatment of Dupuytren disease (DD) is expected to shift towards prevention of progression, the use of imaging in patients with DD becomes more important. In this systematic review an overview is given of the different methods for and applications of imaging for DD that have been described.

Methods: The MEDLINE and EMBASE databases were searched for articles reporting the use of imaging in patients with DD, published before May 17, 2018. Read More

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https://bmcmusculoskeletdisord.biomedcentral.com/articles/10
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http://dx.doi.org/10.1186/s12891-019-2606-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6525391PMC
May 2019
8 Reads

Integrative analysis of Dupuytren's disease identifies novel risk locus and reveals a shared genetic etiology with BMI.

Genet Epidemiol 2019 09 13;43(6):629-645. Epub 2019 May 13.

Bioinformatics Interdepartmental Program, University of California Los Angeles, Los Angeles, California.

Dupuytren's disease is a common inherited tissue-specific fibrotic disorder, characterized by progressive and irreversible fibroblastic proliferation affecting the palmar fascia of the hand. Although genome-wide association study (GWAS) have identified 24 genomic regions associated with Dupuytrens risk, the biological mechanisms driving signal at these regions remain elusive. We identify potential biological mechanisms for Dupuytren's disease by integrating the most recent, largest GWAS (3,871 cases and 4,686 controls) with eQTLs (47 tissue panels from five consortia, total n = 3,975) to perform a transcriptome-wide association study. Read More

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http://dx.doi.org/10.1002/gepi.22209DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6699495PMC
September 2019
14 Reads

Percutaneous Needle Fasciotomy for Dupuytren Contracture.

JBJS Essent Surg Tech 2019 Mar 13;9(1):e6. Epub 2019 Feb 13.

Department of Hand Surgery, Sahlgrenska University Hospital, Gothenburg, Sweden.

Background: Percutaneous needle fasciotomy (PNF) is a minimally invasive treatment option for mild to moderate Dupuytren contractures in the metacarpophalangeal (MCP) and proximal interphalangeal (PIP) joints, and the procedure requires limited resources. Multiple contractures can be treated during the same session, and the treatment is considerably easier for the patient and requires a minimum of rehabilitation compared with limited fasciectomy.

Description: PNF can be performed in a regular outpatient clinic in most cases. Read More

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http://dx.doi.org/10.2106/JBJS.ST.18.00047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6485769PMC
March 2019
8 Reads

Reply: Surgeon Volume and the Outcomes of Dupuytren's Surgery: Results from a Dutch Multicenter Study.

Plast Reconstr Surg 2019 05;143(5):1126e-1127e

Department of Plastic Surgery, Maastricht University Medical Center+, Maastricht, The Netherlands, Xpert Clinic, Amsterdam, Rotterdam, and Eindhoven, The Netherlands Department of Public Health, Erasmus Medical Center, Rotterdam, The Netherlands Xpert Clinic, Amsterdam, Rotterdam, and Eindhoven, The Netherlands Department of Public Health, Erasmus Medical Center, Rotterdam, The Netherlands Departments of Rehabilitation Medicine and Plastic and Reconstructive and Hand Surgery, Erasmus Medical Center, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1097/PRS.0000000000005546DOI Listing
May 2019
6 Reads

Surgeon Volume and the Outcomes of Dupuytren's Surgery: Results from a Dutch Multicenter Study.

Plast Reconstr Surg 2019 05;143(5):1125e-1126e

Plastic and Hand Surgery, Private practice, Bologna, Italy Department of Medicine and Surgery, Plastic Surgery Division, University of Parma, Parma, Italy, Cutaneous, Mininvasive, Regenerative, and Plastic Surgery Unit, Parma University Hospital, Parma, Italy.

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http://dx.doi.org/10.1097/PRS.0000000000005545DOI Listing
May 2019
9 Reads

Investigating the effects of Pirfenidone on TGF-β1 stimulated non-SMAD signaling pathways in Dupuytren's disease -derived fibroblasts.

BMC Musculoskelet Disord 2019 Mar 30;20(1):135. Epub 2019 Mar 30.

Department of Plastic Surgery, University of Pittsburgh, Pittsburgh, PA, 15261, USA.

Background: Dupuytren's disease (DD) is a progressive, debilitating condition of the hand that can eventually cause contractures of the affected fingers. Transforming growth factor- β1 (TGF-β1) has been reported to play a key role in DD pathology. Increased expression of TGF-β1 has shown to be the main stimulator of myofibroblast activity and in DD contractures. Read More

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http://dx.doi.org/10.1186/s12891-019-2486-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441192PMC
March 2019
5 Reads

Tissue adaptation rate in the treatment of Dupuytren contracture.

J Hand Ther 2019 Mar 26. Epub 2019 Mar 26.

Department of Biomechanical Engineering, University of Twente, Enschede, The Netherlands; University of Groningen, University Medical Center Groningen, Department of Rehabilitation Medicine, Groningen, The Netherlands.

Study Design: Basic research (cross-sectional).

Introduction: Dupuytren disease can cause disabling contractures of the finger joints. After partial fasciectomy, postoperative hand splinting helps to maintain extension range of motion. Read More

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http://dx.doi.org/10.1016/j.jht.2018.09.014DOI Listing
March 2019
7 Reads

Discussion: Collagenase Clostridium Histolyticum for Dupuytren Contracture: Comparing Single and Concurrent Injections.

Authors:
Donald H Lalonde

Plast Reconstr Surg 2019 04;143(4):788e-789e

Saint John, New Brunswick, Canada From the Division of Plastic Surgery, Dalhousie University.

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http://dx.doi.org/10.1097/PRS.0000000000005444DOI Listing
April 2019
6 Reads

Percutaneous needle aponeurotomy for the treatment of Dupuytren's contracture.

Eklem Hastalik Cerrahisi 2019 Apr;30(1):53-60

Department of Orthopedics and Traumatology, Turgut Özal Medical Center, İnönü University Medical School, 44100 Malatya, Turkey.

Objectives: This study aims to present the early-period outcomes of patients with Dupuytren's contracture (DC) treated with percutaneous needle aponeurotomy technique.

Patients And Methods: This retrospective study included 28 patients (20 males, 8 females; mean age 63 years; range, 44 to 88 years) (75 fingers) treated with percutaneous aponeurotomy due to DC between November 2011 and December 2015. Patients were evaluated according to their demographic characteristics, presence of additional disease, family history, history of drug use, complication rate, recurrence development, postoperative patient satisfaction, reoperational request, postoperative Disability of Arm Shoulder and Hand Questionnaire and visual analog scale scores. Read More

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http://dx.doi.org/10.5606/ehc.2019.58854DOI Listing
April 2019
7 Reads

Clinical features and management of superficial fibromatoses.

J Dtsch Dermatol Ges 2019 Apr 13;17(4):393-397. Epub 2019 Mar 13.

Department of Dermatology and Allergy Biederstein, Technical University of Munich, Munich, Germany.

Fibromatoses are a group of benign connective tissue tumors characterized by the infiltrative, aggressive proliferation of well-differentiated fibroblasts, leading to frequent local recurrence. Within this heterogeneous disease group, superficial fibromatoses show slower growth and more benign infiltration of surrounding tissues than deep fibromatoses. Superficial fibromatoses relevant to dermatology include palmar, plantar, and penile fibromatosis, knuckle pads, pachydermodactyly and infantile digital fibromatosis. Read More

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http://doi.wiley.com/10.1111/ddg.13808
Publisher Site
http://dx.doi.org/10.1111/ddg.13808DOI Listing
April 2019
22 Reads

Phalangeal fracture leading to digital amputation, sustained during manipulation for Dupuytren's disease as part of clostridial collagenase treatment.

Ann R Coll Surg Engl 2019 Apr 11;101(4):e102-e104. Epub 2019 Mar 11.

Plastic and Reconstructive Surgery Department, Salisbury District Hospital, Salisbury , Salisbury , UK.

Collagenase injection was approved in Europe for use in the treatment of Dupuytren's disease in 2011. Reported adverse effects include skin tears, swelling, pain and complex regional pain syndrome. Here, we present a case of a rare complication of phalangeal fracture following treatment with collagenase clostridium and the resultant digital amputation. Read More

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http://dx.doi.org/10.1308/rcsann.2019.0019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6432953PMC
April 2019
10 Reads