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Plast Reconstr Surg 2022 May 10. Epub 2022 May 10.

From the Division of Plastic and Reconstructive Surgery, Northwestern University Feinberg School of Medicine; Department of Plastic Surgery, Medical College of Wisconsin; and Division of Plastic Surgery, Ann & Robert H. Lurie Children's Hospital.

Background: The American Board of Plastic Surgery collects data on 20 common plastic surgery operations as part of the Continuous Certification process. The goal of this study was to describe clinical trends in Dupuytren contracture repair since 2008 as they relate to evidence-based medicine articles published in this timeframe.

Methods: Cumulative tracer data for Dupuytren contracture were reviewed for the period from February of 2008 to March of 2020 and compared with evidence-based medicine articles published in Plastic and Reconstructive Surgery. Read More

Comput Intell Neurosci 2022 28;2022:3574037. Epub 2022 Apr 28.

Department of Hand and Foot Surgery, Qilu Hospital (Qingdao), Cheeloo College of Medicine, Shandong University, 758 Hefei Road, Qingdao, Shandong 266035, China.

Objective: To study the risk factors of Dupuytren's contracture (DC) and to provide a reference for the clinical prevention and treatment of DC.

Methods: The clinical data of 21 DC patients treated with surgery in Qilu Hospital of Shandong University (Qingdao) from March 2014 to January 2022 were collected. During the same period, 31 subjects who were admitted to the hospital for treatment of finger numbness, difficulty in movement, and other reasons were selected as the control group, and the clinical data of the control group were collected. Read More

Biomed Pharmacother 2022 Apr 12;150:112930. Epub 2022 Apr 12.

Université Côte d'Azur, INSERM, CNRS, IPMC, Valbonne, France. Electronic address:

Dupuytren disease (DD) is a hand-localized fibrotic disorder characterized by a scar-like, collagen-rich cord. Treatment usually comprises surgical removal of the cord, but is associated with a high relapse rate, in some cases requiring finger amputation. There is currently no consensual medical approach for treating DD. Read More

Handchir Mikrochir Plast Chir 2022 Apr 13;54(2):149-154. Epub 2022 Apr 13.

The third Affiliated Hospital of Inner Mongolia Medicial University.

Background: The biological mechanism of Dupuytren's contracture needs to be further studied in order to minimize postoperative recurrence and provide a pathological basis for the development of new therapeutic targets.

Methods: HE staining, immunohistochemistry, PCR and western blotting were performed in pathological palmar aponeurosis specimens and normal palmar aponeurosis tissues for comparative study.

Results: (1) TNF-α expression was up-regulated: TNF-α mRNA was more highly expressed in the pathological tissues of DD patients than in the CT group, P < 0. Read More

J Hand Surg Glob Online 2022 Jan 6;4(1):61-62. Epub 2021 Nov 6.

Division of Plastic Surgery, Albany Medical Center, Albany, NY.

J Hand Surg Glob Online 2021 Sep 26;3(5):272-277. Epub 2021 Jun 26.

Indiana Hand to Shoulder Center, Indianapolis, IN.

Purpose: Current prescribing information for the treatment of patients with Dupuytren contracture with injectable collagenase (CCH) recommends use of a night extension orthosis for 4 months after treatment. The present study examines whether this treatment improves the outcomes.

Methods: Adult patients with Dupuytren contracture treated with CCH during the study period were eligible for inclusion. Read More

Plast Reconstr Surg 2022 Apr 11. Epub 2022 Apr 11.

From the Department of Plastic Surgery, University of Groningen, University Medical Center Groningen; and Department of Mathematics and Computer Science, Eindhoven University of Technology.

Background: Predicting progression of Dupuytren disease becomes relevant in an upcoming era with progression-preventing treatment. This study aimed to determine the course of Dupuytren disease and identify factors associated with progression.

Methods: Two hundred fifty-eight patients with Dupuytren disease participated in this prospective cohort study, obtaining 17,645 observations in 5 years. Read More

J Hand Surg Asian Pac Vol 2022 Apr 31;27(2):320-325. Epub 2022 Mar 31.

Department of Medical Sciences, KU Leuven-University of Leuven, Leuven, Belgium.

Arthrofibrosis is a complication of total knee arthroplasty (TKA) that can lead to poor outcome. Idiopathic arthrofibrosis and Dupuytren disease (DD) have similar histological appearance. The aim of this study is to determine the influence of DD on the recovery of motion after TKAy. Read More

J Hand Surg Asian Pac Vol 2022 Apr 31;27(2):242-247. Epub 2022 Mar 31.

Department of Orthopaedic Surgery, Brigham and Women's Hospital, Boston, MA, USA.

The primary objective of this study was to assess patient preferences for collagenase (CCH) treatment versus limited surgical fasciectomy in a cohort that has undergone both treatments for Dupuytren contracture. We retrospectively identified 68 patients who have undergone both limited surgical fasciectomy and CCH treatment for digital flexion contractures from Dupuytren disease. Patients were contacted by telephone and asked whether they preferred surgery or CCH treatment for their Dupuytren contracture. Read More

J Plast Reconstr Aesthet Surg 2022 Mar 2. Epub 2022 Mar 2.

Department of Orthopedics (Division of Plastic and Hand Surgery), The Second Affiliated Hospital and YuYing Children's Hospital of Wenzhou Medical University, China. Electronic address:

We aim to present a perforator flap-based technique that is useful in the resection and reconstruction of the palmar fascia for the treatment of Dupuytren's contracture with primary closure. A curve incision through the palmar skin radial to the hypothenar area was made. The ulnar side of the palmar skin and the subcutaneous fat was raised to the ulnar side, exposing the palmar fascia. Read More

J Plast Reconstr Aesthet Surg 2021 Nov 30. Epub 2021 Nov 30.

Department of Plastic, Reconstructive and Hand Surgery, Erasmus University Medical Centre, Room EE 15.91b, Dr. Molewaterplein 50, Rotterdam 3015 GE, the Netherlands; Xpert Clinic, Hand and Wrist Surgery, the Netherlands; Department of Plastic, Reconstructive and Hand Surgery, Radboudumc University Hospital, the Netherlands.

Multiple studies have reported the effectiveness of treatment on contracture reduction in Dupuytren's disease. However, very few studies have attempted to quantify to which extent patient and disease characteristics influence the chance of achieving a straight finger after surgery. Therefore, the aim of this study is to explore to which extent pre-operative patient and disease characteristics can reliably predict a straight finger after surgery for Dupuytren's disease. Read More

Gene Ther 2022 Mar 28. Epub 2022 Mar 28.

Department of Hand Surgery, Hand Surgery Research Center, Affiliated Hospital of Nantong University, Nantong, 226001, PR China.

Dupuytren disease (DD) is a progressive fibrous proliferative disease. It invades the palmar aponeurosis and extends to the finger fascia, eventually leading to flexion contracture of the metacarpophalangeal or interphalangeal joint. At present, surgical resection and the local injection of collagenase are the main methods for the treatment of DD, but postoperative complications and high recurrence rates often occur. Read More

J Pers Med 2022 Mar 1;12(3). Epub 2022 Mar 1.

Department of Plastic and Hand Surgery, Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Krankenhausstr. 12, 91054 Erlangen, Germany.

Background: While surgical therapy for Dupuytren's disease is a well-established standard procedure, severe joint flexion deformities in advanced Dupuytren's disease remain challenging to treat. Skeletal distraction has proven to be an additional treatment option.

Methods: We analyzed the surgical treatment algorithm, including the application of a skeletal distraction device, in patients with a flexion deformity due to Dupuytren's disease, Iselin stage III or IV, who were operated on from 2003 to 2020 in our department. Read More

Proc Natl Acad Sci U S A 2022 03 23;119(13):e2120336119. Epub 2022 Mar 23.

The Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford OX3 7FY, United Kingdom.

SignificanceTissue fibrotic diseases, for example of the liver and lung, represent a huge unmet medical need. In this study, using single-cell RNA sequencing, cytometry by time of flight (CyTOF), tissue imaging, and functional assays, we identify a complex vascular niche in Dupuytren's disease (DD), a common localized fibrotic condition of the palm, where early-disease-stage tissue can be accessed readily. We uncover a population of myofibroblast precursors within the pericyte compartment and demonstrate that the endothelium instructs the differentiation of functionally distinct stromal cells, thereby orchestrating discrete microenvironments in the fibrotic milieu. Read More

Adv Biomed Res 2022 31;11. Epub 2022 Jan 31.

Department of Physical Medicine and Rehabilitation, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.

Introduction: We aimed to evaluate the effect of shock wave therapy on the improvement of symptoms and function of patients with Dupuytren's contracture.

Materials And Methods: This research is a pre-post intervention study, conducted among patients referred to the physical medicine clinics of Isfahan during 2019-2020. In this study, subjects experienced shock wave therapy for 6 sessions, each in a week, and improvement of symptoms and function were assessed and compared after the period of study and follow-up (before treatment, 6 weeks after treatment, and 14 weeks after treatment). Read More

Oncologist 2022 03;27(3):e294-e296

Department of Medicine, Memorial Sloan Kettering Cancer Center and Weill Cornell Medical College, New York, NY, USA.

Palmar and plantar fibromatosis are benign proliferative processes which present as a diffuse thickening or nodules of the hands and/or feet and may lead to flexion contractures, pain, and functional impairment known as Dupuytren and Ledderhose diseases, respectively. Current treatments are noncurative and associated with significant morbidity. Here, we report on the outcomes of 5 patients with advanced disease, no longer surgical candidates, treated with sorafenib. Read More

Plast Reconstr Surg 2022 05 11;149(5):914e-920e. Epub 2022 Mar 11.

From the Mayo Clinic.

Background: There have been no formal studies of the use of collagenase clostridium histolyticum (Xiaflex; Endo Pharmaceuticals, Malvern, Pa.) in the anticoagulated patient. Previous study on its use excluded patients receiving anticoagulation therapy. Read More

Rom J Morphol Embryol 2021 Jul-Sep;62(3):777-784

Department of Medical Informatics and Biostatistics, George Emil Palade University of Medicine, Pharmacy, Science and Technology, Târgu Mureş, Romania;

Background And Objectives: Dupuytren's disease (DD) is a chronic progressive disorder causing contractures in the palmar and digital fascia. The primary aim of management is to correct the deformity while reducing the risk of recurrence and avoiding complications. The purpose of our retrospective study was to validate the efficacity, safety and the rate of recurrence of DD after percutaneous needle fasciotomy (PNF). Read More

Disabil Rehabil 2022 Mar 9:1-11. Epub 2022 Mar 9.

Department of Hand Surgery, Plastic Surgery and Burns in Linköping, and Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.

Purpose: To describe patients' perspectives of collagenase injection or needle fasciotomy for Dupuytren disease (DD) including hand therapy, and their view of hand function and occupational performance.

Materials And Methods: Interviews were performed with twelve patients who had undergone non-surgical treatment and rehabilitation for DD. Data was analysed using a problem-driven content analysis using the model of Patient Evaluation Process as a theoretical framework. Read More

Hand (N Y) 2022 Mar 6:15589447221077375. Epub 2022 Mar 6.

Mayo Clinic Arizona, Phoenix, USA.

Background: This article compares the rates and time-to-development of new-onset Dupuytren disease in patients with trigger finger treated by steroid injection, surgical release, or both.

Methods: PearlDiver's Mariner 30 database was queried to identify patients with trigger finger between January 2010 and June 2019. One-to-one exact matching based on baseline patient demographics allowed us to create 4 identical groups defined by the type of trigger finger intervention received. Read More

Math Biosci Eng 2022 01;19(3):2876-2895

Laboratoire Mathématiques de Besançon, UMR - CNRS 6623 Université de Bourgogne Franche-Comté, Besançon 25000, France.

In this study we review the current state of the art for Dupuytren's disease (DD), while emphasising the need for a better integration of clinical, experimental and quantitative predictive approaches to understand the evolution of the disease and improve current treatments. We start with a brief review of the biology of this disease and current treatment approaches. Then, since certain aspects in the pathogenesis of this disorder have been compared to various biological aspects of wound healing and malignant processes, next we review some (mathematical modelling and simulations) predictive approaches for complex multi-scale biological interactions occurring in wound healing and cancer. Read More

Cureus 2022 Jan 26;14(1):e21636. Epub 2022 Jan 26.

Pharmacy, Hospital Universitario de La Plana, Villareal, ESP.

Background: Unité Rhumatologique des Affections de la Main (URAM) is a novel and disease-specific questionnaire for Dupuytren contracture, a fibroproliferative disease that affects hands causing progressive contracture in flexion of the fingers.

Objectives: To evaluate the sensitivity and specificity of the URAM scale in Dupuytren contracture.

Materials And Methods: We performed meta-analyses of 10 articles published in PubMed, Embase, Cochrane, Google Scholar, Latin American and Caribbean Health Sciences Literature (LILACS), and in various grey literature databases that describe the use of the URAM and Tubiana scales to assess treatment outcomes in Dupuytren contracture. Read More

Plast Reconstr Surg 2022 Apr;149(4):913-917

From the Discipline of Occupational Therapy, School of Health Science and Social Work, Griffith University; and Occupational Therapy Department, Queen Elizabeth II Jubilee Hospital, Metro South Hospital and Health Service.

Background: Collagenase injection is a relatively new, minimally invasive treatment option for Dupuytren disease. Most literature focusses on quantitative outcome measures, such as degree of residual contracture and recurrence. The patient experience of the treatment has rarely been explored. Read More

J Hand Surg Asian Pac Vol 2022 Feb 9;27(1):187-190. Epub 2022 Feb 9.

Orthopaedic Department, Leuven University Hospitals, Leuven, Belgium.

Pulley injuries and Dupuytren disease are quite common in rock climbing. We report a rock climber who was treated for a Dupuytren contracture with collagenase injection therapy. Two months later, he developed a traumatic pulley injury during climbing and was treated with a ring orthosis. Read More

J Hand Surg Asian Pac Vol 2022 Feb 9;27(1):141-147. Epub 2022 Feb 9.

Department of Trauma & Orthopaedic Surgery, University Hospital Galway, Merlin Park, Galway, Ireland.

Collagenase clostridium histolyticum has become a widely used treatment in the management of Dupuytren disease. The aims of this study are to assess the immediate success of treatment of Dupuytren contracture with collagenase injection, to measure long-term patient-rated outcomes, to determine whether the risk factors for the disease impacted outcomes and to report complications of collagenase treatment. A prospective study was performed in a tertiary referral centre. Read More

J Plast Reconstr Aesthet Surg 2022 Jan 20. Epub 2022 Jan 20.

Department of Orthopedic Surgery, Seoul National University Bundang Hospital, Seoul National University College of Medicine, 82 Gumi-ro 173, Bundang-gu, Seongnam-si, Gyeonggi-do 13620, Republic of Korea. Electronic address:

Background: Dupuytren's disease (DD) is a progressive fibroproliferative condition involving contractures of the fascia of the palm. Up to now, there are no relevant investigations on patients with DD in case of serum vitamin D deficiency. We hypothesized that transforming growth factor-β1 (TGF-β1) is increased in patients with DD in consequence of vitamin D deficiency, thereby leading to myofibroblast differentiation and subsequent progression of contractures. Read More

Hand (N Y) 2022 Feb 8:15589447211066347. Epub 2022 Feb 8.

University of Michigan, Ann Arbor, USA.

Autologous fat grafting (AFG) has traditionally been used for facial rejuvenation and soft tissue augmentation, but in recent years, its use has expanded to treat diseases of the hand. Autologous fat grafting is ideal for use in the hand because it is minimally invasive, can restore volume, and has regenerative capabilities. This review summarizes the emerging evidence regarding the safety and efficacy of AFG to the hand in several conditions, including systemic sclerosis, Dupuytren disease, osteoarthritis, burns, and traumatic fingertip injuries. Read More

Pharm Dev Technol 2022 Feb 20;27(2):242-250. Epub 2022 Feb 20.

James L. Winkle College of Pharmacy, University of Cincinnati, Cincinnati, OH, USA.

Dupuytren's disease is a progressive fibrotic condition of the hand that causes contracture of fingers in later stages. Our previous studies suggest that the transformation of fibroblasts to myofibroblasts induced by transforming growth factor-beta can be inhibited by the addition of the antifibrotic drug, pirfenidone (PFD). We hypothesize that the local delivery of PFD directly to nodules can potentially prevent the progression to cords and, furthermore, that injection of PFD after the resection of cords can limit the recurrence of the disease. Read More

Orthop J Sports Med 2022 Jan 25;10(1):23259671211069577. Epub 2022 Jan 25.

Department of Orthopaedic Surgery, University of California-San Francisco, San Francisco, California, USA.

Background: Nonoperative and operative treatment modalities have been used for symptom management of adhesive capsulitis, but neither has been shown to significantly alter the long-term natural history.

Purpose/hypothesis: The purpose was to evaluate the current trends in resource and treatment strategy utilization for patients with adhesive capsulitis. It was hypothesized that (1) patients with idiopathic adhesive capsulitis will primarily undergo nonoperative treatment and (2) patients with systemic medical comorbidities will demonstrate relatively higher utilization of nonoperative therapies. Read More

Hand (N Y) 2022 Jan 29:15589447211072251. Epub 2022 Jan 29.

Massachusetts General Hospital, Harvard Medical School, Boston, USA.

Background: A multitude of treatments for Dupuytren contracture are available, including both invasive and minimally invasive options. This study compares the reintervention rates and costs associated with various treatment options for Dupuytren disease (DD) within the Veterans Affairs (VA) Health Administration.

Methods: Using the Corporate Data Warehouse, a national census was performed including all patients treated for DD in years 2014 to 2020 within the VA health care system. Read More