Search Our Scientific Publications & Authors

Jt Dis Relat Surg 2023 Aug 21;34(3):737-740. Epub 2023 Aug 21.

Department of Plastic and Reconstructive Surgery, Seoul St. Mary's Hospital, The Catholic University of Korea, 06591 Seoul, South Korea.

Dupuytren's disease is a fibroproliferative disease that affects the palmar hand, causing progressive, permanent, and symptomatic flexion contracture of the digits. It is a disorder of polygenetic and multifactorial origin, usually affecting middle-aged males. Dupuytren's disease developing as a result of hand trauma in younger ages is rarely reported. Read More

J Hand Surg Am 2023 Sep 16. Epub 2023 Sep 16.

Department of Orthopaedic Surgery, Brigham and Women's Hospital, Boston, MA; Harvard Medical School, Boston, MA.

Purpose: The objective of this systematic review and meta-analysis was to synthesize the available randomized controlled trial data comparing needle fasciotomy and collagenase treatment for single-digit Dupuytren contractures with a minimum of 3-year follow-up and determine whether one treatment is superior regarding contracture correction and functional outcomes.

Methods: A systematic review and meta-analysis was conducted by searching four databases for randomized controlled trials investigating the single-digit treatment outcomes for Dupuytren contracture comparing collagenase treatment and needle fasciotomy with a minimum of 3-year follow-up. The risk of bias of included studies was assessed using the Cochrane risk-of-bias tool. Read More

Acta Chir Plast 2023 ;65(2):74-78

This paper describes the evaluation options of Dupuytren's contracture by subjective and objective methods. There are various classification schemes named after their authors, including graphical representation for objective evaluation of the disease. Subjective assessment was performed in the form of a questionnaire for patients. Read More

Front Immunol 2023 31;14:1230027. Epub 2023 Aug 31.

Department of Orthopedics, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.

Background: Frozen shoulder (FS) and Dupuytren's disease (DD) are two closely related diseases, but the mechanism of their interaction is unknown. Our study sought to elucidate the molecular mechanism of these two diseases through shared gene and protein interactions.

Methods: GSE75152 and GSE140731 data were downloaded from the Gene Expression Omnibus (GEO) database, and shared genes between FS and DD were selected by using R packages. Read More

Plast Reconstr Surg Glob Open 2023 Sep 7;11(9):e5239. Epub 2023 Sep 7.

From the Department of Orthopaedic Surgery, University of California, Los Angeles, Calif.

Collagenase is a popular treatment in Dupuytren contracture. Current guidelines are for manipulation 24 hours to 7 days after injection. We present a case of successful manipulation 28 days after injection. Read More

BMC Med Genomics 2023 Sep 7;16(1):212. Epub 2023 Sep 7.

Department of Orthopedics, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi, 214000, China.

Background: The correlation between smoking and alcohol consumption and the development of Dupuytren's disease (DD) has been acknowledged. However, the definitive causal relationship between these two factors and DD remains elusive. In order to establish a causal connection, we employed the two-sample Mendelian randomization method to evaluate the relationship between smoking and alcohol consumption and DD. Read More

Arch Orthop Trauma Surg 2023 Sep 4. Epub 2023 Sep 4.

Department of Plastic and Hand Surgery, Inselspital, University Hospital of Bern, Freiburgstrasse 18, 3010, Bern, Switzerland.

Introduction: The aim of the present study is to systematically review the literature on well-selected comparative studies for meta-analysis on outcome differences between collagenase clostridium histolyticum (CCH) injection and limited fasciectomy (LF) for Dupuytren's disease.

Materials And Methods: PubMed/Medline, Embase, and the Cochrane Library were searched for comparative studies assessing differences in outcomes of CCH and LF. Effect estimates were pooled across studies using random effects models and presented as weighted mean difference (MD) and odds ratio (OR) with corresponding 95% confidence interval (CI). Read More

Prim Care Diabetes 2023 Aug 27. Epub 2023 Aug 27.

Department of Rheumatology and Immunology, Medical School, University of Pécs, Pécs, Hungary. Electronic address:

The current study ushers in a comprehensive review in clinical research to demonstrate the prevalence of musculoskeletal (MSK) complications in diabetes mellitus and the most relevant clinical aspects. In particular, revealing the early symptoms of the disorders, the pathology lurking behind the complications and their optimal management. In diabetes mellitus, MSK complications are common and are largely due to similar pathogenetic factors responsible for the internal organ complications associated with diabetes leading to chronic low-intensity inflammatory processes. Read More

Cureus 2023 Jul 27;15(7):e42540. Epub 2023 Jul 27.

Pain Management, Broward Spine Institute, Hollywood, USA.

Every day, people of all ages in the United States break bones, with traumatic injury being the most common way, and wrist injury being in the top five most common areas in which bones break. Traumatic fractures are managed with either surgical or nonsurgical approaches. The surgical approach utilizes ortho procedures such as internal fixation and reduction, while the nonsurgical approach consists of procedures like RICE, ace bandage, and so on. Read More

Int J Impot Res 2023 Aug 25. Epub 2023 Aug 25.

Section of Urology, Department of Surgery, University of Manitoba, Winnipeg, MB, Canada.

Collagenase Clostridium histolyticum (CCh), the first approved non-surgical treatment for Peyronie's disease (PD), was withdrawn from the European, Canadian, and Asian markets due to poor demand and lack of government reimbursement options. We sought to assess insurance approval rates and usage of CCh across Canada to understand the factors that led to its withdrawal. Data on patients prescribed CCh for PD or Dupuytren's contracture was obtained through collaboration with BioScript Solutions to assess the association of variables with insurance approval and prescription filling. Read More

J Hand Surg Am 2023 Aug 21. Epub 2023 Aug 21.

Division of Plastic and Reconstructive Surgery, University of California, Los Angeles, CA; Department of Orthopaedic Surgery, University of California, Los Angeles, CA. Electronic address:

Purpose: Dupuytren disease can be managed with an injection of collagenase Clostridium histolyticum enzyme followed by manual manipulation. Although the recommended time from injection to manipulation is 24-72 hours, patient and physician schedules may not accommodate this time frame. Therefore, we sought to study the impact of time from injection to manipulation on outcomes and complications of collagenase injection. Read More

Med Acupunct 2023 Aug 14;35(4):202-204. Epub 2023 Aug 14.

Bone Joint Res 2023 Aug 4;12(8):486-493. Epub 2023 Aug 4.

Department of Orthopaedic Surgery, School of Medicine, University of Occupational and Environmental Health, Fukuoka, Japan.

Aims: Dupuytren's contracture is characterized by increased fibrosis of the palmar aponeurosis, with eventual replacement of the surrounding fatty tissue with palmar fascial fibromatosis. We hypothesized that adipocytokines produced by adipose tissue in contact with the palmar aponeurosis might promote fibrosis of the palmar aponeurosis.

Methods: We compared the expression of the adipocytokines adiponectin and leptin in the adipose tissue surrounding the palmar aponeurosis of male patients with Dupuytren's contracture, and of male patients with carpal tunnel syndrome (CTS) as the control group. Read More

J Hand Surg Glob Online 2023 Jul 16;5(4):492-497. Epub 2022 Aug 16.

Carl J. Shapiro Department of Orthopaedics, Beth Israel Deaconess Medical Center, Boston, MA.

As health care systems globally shift toward optimizing value, defined as health outcomes achieved per dollar spent across a full cycle of care, there has been increasing focus on using patient-reported outcome measures (PROMs) to gauge success. Patient-reported outcome measures are validated questionnaires that allow patients to share their health status across several domains (eg, pain or physical function). This trend has been particularly notable in hand surgery, with PROM use investigated for many common hand conditions, including carpal tunnel syndrome, Dupuytren contracture, trigger finger, osteoarthritis, and wrist ganglion. Read More

Arch Orthop Trauma Surg 2023 Oct 24;143(10):6477-6485. Epub 2023 Jul 24.

Department of Plastic and Hand Surgery, Friedrich Alexander University Erlangen-Nuremberg FAU, Krankenhausstr 12, 91054, Erlangen, Germany.

Background: Carpal tunnel syndrome, A1 annular pulley stenosis and Dupuytren's contracture are among the most common conditions of the hand. In this study, we investigated the impact of surgical procedure on hand grip strength and high-resolution spatial load distribution in individuals suffering from those diseases over a follow-up period of one year.

Materials And Methods: In this prospective study, data of 9 patients with carpal tunnel syndrome, 12 patients with A1 annular pulley stenosis and 7 patients with Dupuytren's contracture were evaluated. Read More

Hand (N Y) 2023 Jul 23:15589447231185581. Epub 2023 Jul 23.

Universidade Federal de São Paulo - Escola Paulista de Medicina, São Paulo, Brazil.

Background: Dupuytren is a fibroproliferative pathology leading to contracture of the palmar fascia. Several approaches have been described for the surgical treatment with partial fasciectomy with few comparisons in literature. Our purpose is to compare the functional outcomes between the partial fasciectomy performed by Bruner type incision and zetaplasty incision. Read More

J Hand Surg Am 2023 Sep 20;48(9):914-922. Epub 2023 Jul 20.

Center for Tissue Engineering, Department of Plastic Surgery, University of California, Orange, CA. Electronic address:

Purpose: Currently, no treatment corrects the contractile nature of Dupuytren myofibroblasts (DMFs) or prevents recurrence following surgery. Antifibrotic and proadipogenic growth factors are released when adipose-derived stem cells (ASCs) are cultured with platelet-rich plasma (PRP), a platelet concentration from whole blood. Reprograming myofibroblasts into adipocytes via growth factors is proposed as a powerful potential tool to target fibrosis. Read More

Hand Clin 2023 Aug 11;39(3):455-463. Epub 2023 May 11.

The Hand and Upper Extremity Center, The Ohio State University, 915 Olentangy River Road, Suite 3200, Columbus, OH 43212, USA. Electronic address:

Dupuytren disease is a common pathologic condition that can be especially challenging to hand surgeons in recurrent or severe contractures. Recurrence risk may be reduced with a variety of techniques, including skin grafting, external fixator application, radiation, and many others described in this article. Management of recurrence requires special attention to anatomy at risk. Read More

Commun Med (Lond) 2023 Jul 13;3(1):96. Epub 2023 Jul 13.

Department of Orthopedics, State University of New York at Stony Brook, HSC T18 Room 092, Stony Brook, NY, 11794-8181, USA.

Background: Dupuytren's disease (DD) is a fibroproliferative hand disorder associated with various medical conditions, including diabetes mellitus (DM). The reported prevalence of DM among DD patients varies widely, primarily due to small sample sizes in previous studies.

Methods: This was a retrospective cohort study using data from the TriNetX Research Database. Read More

Handchir Mikrochir Plast Chir 2023 Sep 10;55(5):330-335. Epub 2023 Jul 10.

Klinik für Unfall-, Hand- und Wiederherstellungschirurgie, Universitätsklinikum Frankfurt am Main, Frankfurt am Main, Germany.

Background: Dupuytren's disease often leads to an increasing limitation in finger extension in affected patients. As the incidence rises with age, the number of cases is expected to rise in the future due to the demographic change. Therefore, an easy and patient-oriented treatment is required. Read More

Mil Med 2023 Aug;188(9-10):248-249

Future Forward Research Institute, Toms River, NJ 08757, USA.

Cureus 2023 May 24;15(5):e39449. Epub 2023 May 24.

Orthopedic Surgery, University of Rochester, Rochester, USA.

Orthopedic surgery literature utilizes numerous eponyms, and they have become commonplace among orthopedic surgeons and the general public alike. These eponyms can have important historical implications and their history is often overlooked by the physicians using such terms. This paper seeks to specifically explore the origins of eponyms in orthopedic soft tissue diseases involving the upper extremity. Read More

Med Acupunct 2023 Jun 15;35(3):144-145. Epub 2023 Jun 15.

Hand Surg Rehabil 2023 Sep 17;42(4):273-283. Epub 2023 Jun 17.

Department of Orthopedic Surgery-Hand Unit, University Hospitals Leuven, Herestraat 49, 3000 Leuven, Belgium.

Dupuytren's disease is a progressive hand disorder characterized by the formation of pathologic nodules and cords in the palm, often leading to progressive flexion contractures. Hand surgery is currently the only efficient treatment to restore hand function, however, reported recurrence rates vary widely. Currently, it remains unclear which type of fasciectomy is associated with the lowest recurrence rate. Read More

Mol Biol Evol 2023 Jun;40(6)

Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.

Dupuytren's disease is characterized by fingers becoming permanently bent in a flexed position. Whereas people of African ancestry are rarely afflicted by Dupuytren's disease, up to ∼30% of men over 60 years suffer from this condition in northern Europe. Here, we meta-analyze 3 biobanks comprising 7,871 cases and 645,880 controls and find 61 genome-wide significant variants associated with Dupuytren's disease. Read More

Plast Reconstr Surg Glob Open 2023 Jun 12;11(6):e5063. Epub 2023 Jun 12.

From the Division of Plastic and Reconstructive Surgery, University of Colorado Anschutz Medical Center, Aurora, Col.

Unlabelled: Dupuytren disease is associated with inflammation and myofibroblast overgrowth, as is stenosing tenosynovitis (trigger finger). Both are linked with fibroblast proliferation, but a potential associative link between the diseases is unknown. The purpose of this study was to evaluate the progression of trigger finger following treatment for Dupuytren contracture in a large database. Read More

Hand (N Y) 2023 Jun 2:15589447231175512. Epub 2023 Jun 2.

University of Rochester Medical Center, NY, USA.

Background: The Digit Widget is an external fixation device that can be used to reverse proximal interphalangeal joint (PIPJ) contractures in the hand. Our hypothesis is that usage of the Digit Widget prior to fasciectomy in patients with severe Dupuytren's proximal interphalangeal (PIP) contractures will result in short-term improvement and maintenance of the PIPJ contracture after fasciectomy.

Methods: Patients who underwent placement of the Digit Widget soft tissue distractor prior to fasciectomy for Dupuytren's disease were identified between January 2015 and December 2018. Read More

J Hand Surg Am 2023 May 29. Epub 2023 May 29.

Florida Orthopaedic Institute, Temple Terrace, FL.

Purpose: Injectable collagenase Clostridium histolyticum has been an effective and well-tolerated nonsurgical treatment option for the management of Dupuytren contracture of the hand. The purpose of this study was to determine the efficacy of collagenase injection and adverse event rate in patients who had undergone previous collagenase treatment.

Methods: A retrospective chart review was performed on 332 patients treated with collagenase injection for Dupuytren contracture by three fellowship-trained hand surgeons at a single institution from 2009 to 2019. Read More

Hand (N Y) 2023 May 28:15589447231174175. Epub 2023 May 28.

The University of Adelaide, SA, Australia.

Background: Dupuytren disease is a common fibroproliferative disease that affects the palmar fascia of the hands. Currently, there is limited consensus regarding the optimal therapy for this condition, with treatment decisions based largely on surgeon preference. Therefore, the aim of this study was to determine which treatments are the most effective for Dupuytren disease. Read More