65,968 results match your criteria Duodenum


The origin of N isotopic discrimination and its relationship with feed efficiency in fattening yearling bulls is diet-dependent.

PLoS One 2020 5;15(6):e0234344. Epub 2020 Jun 5.

INRAE, Université Clermont Auvergne, Vetagro Sup, UMRH, Saint-Genès-Champanelle, France.

Nitrogen (N) isotopic discrimination (i.e. the difference in natural 15N abundance between the animal proteins and the diet; Δ15N) is known to correlate with N use efficiency (NUE) and feed conversion efficiency (FCE) in ruminants. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0234344PLOS

Type II enteropathy-associated T cell lymphoma in the duodenum: A rare case report.

Medicine (Baltimore) 2020 Jun;99(23):e20050

Department of Gastroenterological Surgery.

Introduction: Enteropathy-associated T-cell lymphoma (EATL) is a very rare form of lymphoma in the gastrointestinal tract. The proximal jejunum and ileum are the most common sites of EATL, whereas EATL rarely arises in the duodenum, and EATL involving metastasis of the bilateral ovaries is even rarer.

Patient Concerns: A 43-year-old female suffered from upper abdominal pain and weight loss for 3 months. Read More

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http://dx.doi.org/10.1097/MD.0000000000020050DOI Listing

The expression levels of CHI3L1 and IL15Rα correlate with TGM2 in duodenum biopsies of patients with celiac disease.

Inflamm Res 2020 Jun 4. Epub 2020 Jun 4.

Anatomy, Histology and Movement Sciences, Department of Biomedical and Biotechnological Sciences, School of Medicine, University of Catania, Via S. Sofia 87, 95125, Catania, Italy.

Objective And Design: Celiac disease (CD) is an intestinal inflammatory disorder of the small intestine. Gliadins are a component of gluten and there are three main types (α, γ, and ω). Recent studies indicate that gliadin peptides are able to activate an innate immune response. Read More

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http://dx.doi.org/10.1007/s00011-020-01371-9DOI Listing

The microbial biogeography of the gastrointestinal tract of preterm and term lambs.

Sci Rep 2020 Jun 4;10(1):9113. Epub 2020 Jun 4.

Liggins Institute, The University of Auckland, Auckland, New Zealand.

Nutritional supplementation is a common clinical intervention to support the growth of preterm infants. There is little information on how nutritional supplementation interacts with the developing microbiome of the small intestine, the major site for nutrient metabolism and absorption. We investigated the effect of preterm birth and nutritional supplementation on the mucosal and luminal microbiota along the gastrointestinal tract (GIT) of preterm lambs. Read More

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http://dx.doi.org/10.1038/s41598-020-66056-zDOI Listing

Gallstone Disease and Microbiome.

Microorganisms 2020 Jun 2;8(6). Epub 2020 Jun 2.

Laboratory of Gastroenterology, Research Institute of Internal and Preventive Medicine-Branch of The Federal Research Center Institute of Cytology and Genetics of Siberian Branch of Russian Academy of Sciences, Novosibirsk 630089, Russia.

Gallstone disease (GSD) has, for many years, remained a high-cost, socially significant public health problem. Over the past decade, a number of studies have been carried out-both in humans and in animal models-confirming the role of the microbiota in various sections of the gastrointestinal tract as a new link in the etiopathogenesis of GSD. The microbiome of bile correlates with the bacterial composition of saliva, and the microbiome of the biliary tract has a high similarity with the microbiota of the duodenum. Read More

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http://dx.doi.org/10.3390/microorganisms8060835DOI Listing

Effects of supplemental xylanase on health of the small intestine in nursery pigs fed diets with corn distillers' dried grains with solubles.

J Anim Sci 2020 Jun 4. Epub 2020 Jun 4.

Department of Animal Science, North Carolina State University, Raleigh, USA.

Forty pigs (10.7 ± 1.2 kg initial BW at 6 wk of age) were used in a 21-d study to evaluate the effects of supplemental xylanase (Hostazym X 100, Huvepharma, Inc. Read More

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http://dx.doi.org/10.1093/jas/skaa185DOI Listing

Artificial Vascular Graft Migration into Hollow Viscus Organs in Patients who Underwent Right Lobe Living Donor Liver Transplantation.

Acta Chir Belg 2020 Jun 4:1-18. Epub 2020 Jun 4.

Liver Transplant Institute, Inonu University, 44280, Malatya, Turkey.

To share our experience with hollow viscus migration of artificial vascular grafts (AVG) used for venous reconstruction of the right anterior sector in living donor liver transplantations (LDLT). Clinical, radiological, and endoscopic data of 13 right lobe LDLT patients (range: 26-67 years) with a diagnosis of postoperative AVG migration into adjacent hollow viscus were analyzed.: Biliary complications were detected in 12 patients. Read More

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Jejunal Diverticulosis Complicated by Diverticulitis and Small Bowel Obstruction.

Cureus 2020 May 28;12(5):e8347. Epub 2020 May 28.

Trauma and Surgical Critical Care, Warren Alpert Medical School of Brown University, Providence, USA.

Diverticular disease is common in the Western population and can cause considerable morbidity. The prevalence of colonic diverticulosis reaches 60% by the age of 60 years. Small bowel diverticulosis is much rarer and, when present, most commonly occurs in the duodenum. Read More

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http://dx.doi.org/10.7759/cureus.8347DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7263004PMC

Missed opportunity of deworming a Maasai boy from nomadic family leading to life threatening intestinal obstruction.

J Surg Case Rep 2020 May 26;2020(5):rjaa096. Epub 2020 May 26.

Department of pathology, Kilimanjaro Christian Medical Centre, Moshi, Tanzania.

Mass deworming against soil-transmitted helminthiasis, including (AL), is one of the largest public health interventions in low- and middle-income countries. The prevalence of in Tanzania is 6.8%. Read More

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http://dx.doi.org/10.1093/jscr/rjaa096DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7251234PMC

Effects of Flavanols on Enteroendocrine Secretion.

Biomolecules 2020 Jun 1;10(6). Epub 2020 Jun 1.

MoBioFood Research Group, Departament de Bioquímica i Biotecnologia, Universitat Rovira i Virgili, c/Marcel·lí Domingo nº1, 43007 Tarragona, Spain.

Some beneficial effects of grape seed proanthocyanidin extract (GSPE) can be explained by the modulation of enterohormone secretion. As GSPE comprises a combination of different molecules, the pure compounds that cause these effects need to be elucidated. The enterohormones and chemoreceptors present in the gastrointestinal tract differ between species, so if humans are to gain beneficial effects, species closer to humans-and humans themselves-must be used. Read More

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http://dx.doi.org/10.3390/biom10060844DOI Listing

Bouveret's syndrome as a rare complication of cholelithiasis: Disputes in current management and report of two cases.

Int J Surg Case Rep 2020 May 25;71:315-318. Epub 2020 May 25.

General Surgery Department, San Salvatore Hospital, Paternò, Catania, Italy.

Introduction: Bouveret's syndrome is a rare complication of cholelithiasis that determines an unusual type of gallstone ileus, secondary to an acquired fistula between the gallbladder and either the duodenum or stomach with impaction of a large gallbladder stone. Preoperative diagnosis is difficult because of its rarity and the absence of typical symptoms. Adequate treatment consists of endoscopic or surgical removal of obstructive stone. Read More

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http://dx.doi.org/10.1016/j.ijscr.2020.05.019DOI Listing

Risks, Benefits, and Effects on Management for Biopsy of the Papilla in Patients with Familial Adenomatous Polyposis.

Clin Gastroenterol Hepatol 2020 May 31. Epub 2020 May 31.

Department of Gastroenterology, Hepatology, and Nutrition, Digestive Disease and Surgery Institute, Cleveland Clinic, Cleveland, OH, United States. Sanford R. Weiss, MD Center for Hereditary Colorectal Neoplasia, Digestive Disease and Surgery Institute, Cleveland Clinic, Cleveland, OH, United States.

Background & Aims: Ampullary and duodenal cancer are the leading causes of death in patients with familial adenomatous polyposis (FAP) after colectomy has been performed. Risk of duodenal cancer is determined based on Spigelman stage (SS) of duodenal polyposis. Guidelines recommend endoscopic surveillance of the duodenum and visualization of the papilla to stage duodenal polyposis. Read More

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http://dx.doi.org/10.1016/j.cgh.2020.05.054DOI Listing

Imaging findings of glomus tumor at duodenum: a case description.

Quant Imaging Med Surg 2020 May;10(5):1133-1137

Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.

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http://dx.doi.org/10.21037/qims.2020.03.22DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7242293PMC

Effects of graded dose dietary supplementation of leaf meal and leaf meal on growth performance, apparent ileal digestibility, and gut morphology in broilers.

Saudi J Biol Sci 2020 Jun 18;27(6):1503-1513. Epub 2020 Apr 18.

Department of Preclinical Sciences, Faculty of Veterinary Medicine, Universiti Putra Malaysia, 43400 UPM, Serdang, Selangor, Malaysia.

Due to antimicrobial resistance and the public health hazard of antibiotic growth promoters, there is a grave need to find potential alternatives for sustainable poultry production. (PB) and (PO) are herbs, which have been reported for antimicrobial, antioxidant, and anti-inflammatory properties. The present study aimed to estimate the influence of different dose supplementation of leaf meal (PBLM) and leaf meal (POLM) on growth performance, ileal digestibility and gut morphology of broilers chickens. Read More

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http://dx.doi.org/10.1016/j.sjbs.2020.04.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7254159PMC

Targeted-gene sequencing of an undifferentiated gallbladder carcinoma: a case report.

Diagn Pathol 2020 Jun 2;15(1):66. Epub 2020 Jun 2.

Department of Pathology, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing, PR China.

Background: Undifferentiated carcinomas of the gallbladder are extremely rare. Most undifferentiated carcinomas are accompanied by adjacent foci of other conventional carcinomas, and a transition zone is shared between them. However, genetic alterations of undifferentiated gallbladder carcinoma and the similarities or differences between the undifferentiated carcinoma and the foci conventional carcinoma are unknown. Read More

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http://dx.doi.org/10.1186/s13000-020-00981-5DOI Listing

Nationwide Multicenter Study of Eosinophilic Esophagitis in Korean Children.

Pediatr Gastroenterol Hepatol Nutr 2020 May 8;23(3):231-242. Epub 2020 May 8.

Department of Pediatrics, Seoul National University Bundang Hospital, Sungnam, Korea.

Purpose: In East Asian countries, there are only a few epidemiologic studies of eosinophilic esophagitis (EoE) and no studies in children. We investigated the incidence and compared the clinical characteristics of EoE and eosinophilic gastroenteritis involving the esophagus (EGEIE) in Korean children.

Methods: A total of 910 children, who had symptoms of esophageal dysfunction, from 10 hospitals in Korea were included. Read More

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http://dx.doi.org/10.5223/pghn.2020.23.3.231DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7231742PMC

[Pathological characteristics and survival analysis of 355 patients with gastroenteropancreatic neuroendocrine neoplasms].

Zhonghua Zhong Liu Za Zhi 2020 May;42(5):426-431

Third Department of Surgery, Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, China.

Biological behavior, pathological characteristics and prognostic factors of 355 cases with gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) were analyzed in this retrospective study. In our study, 355 patients pathologically diagnosed as GEP-NENs were identified from April 2006 to November 2017 in the Fourth Hospital of Hebei Medical University. The biological behavior, pathological characteristics and prognosis were analyzed retrospectively. Read More

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http://dx.doi.org/10.3760/cma.j.cn112152-112152-20191011-00663DOI Listing

L-glutamate stimulates cholecystokinin secretion via the T1R1/T1R3 mediated PLC/TRPM5 transduction pathway.

J Sci Food Agric 2020 Jun 1. Epub 2020 Jun 1.

National Center for International Research on Animal Gut Nutrition, Nanjing Agricultural University, Nanjing, 210095, China.

Background: It is known that cholecystokinin (CCK) plays an essential role in reducing food intake and driving weight loss. Previous studies demonstrated that amino acids were capable of triggering CCK release through G protein-coupled receptors, but the sensing mechanism remains obscure, especially the intracellular signaling pathway.

Results: L-Glu rather than its D-isomer robustly stimulated CCK secretion in a porcine duodenal model, and the secretory response was augmented by incubation with the allosteric ligand of T1R1, while T1R3 antagonist attenuated it. Read More

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http://dx.doi.org/10.1002/jsfa.10541DOI Listing

Optical Biopsy of the Upper GI Tract Using Fluorescence Lifetime and Spectra.

Front Physiol 2020 13;11:339. Epub 2020 May 13.

School of Biomedical Engineering, Faculty of Engineering, McMaster University, Hamilton, ON, Canada.

Screening and surveillance for gastrointestinal (GI) cancers by endoscope guided biopsy is invasive, time consuming, and has the potential for sampling error. Tissue endogenous fluorescence spectra contain biochemical and physiological information, which may enable real-time, objective diagnosis. We first briefly reviewed optical biopsy modalities for GI cancer diagnosis with a focus on fluorescence-based techniques. Read More

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http://dx.doi.org/10.3389/fphys.2020.00339DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7237753PMC

Successful endoscopic treatment of a large impacted gallstone in the duodenum using laser lithotripsy, Bouveret's syndrome: A case report.

World J Gastroenterol 2020 May;26(19):2458-2463

Department of Gastroenterology, Franciscus Gasthuis & Vlietland, Rotterdam 3045 PM, Zuid-Holland, Netherlands.

Background: Bouveret´s syndrome is defined as a gastric outlet obstruction after passage of a gallstone through a fistula into the duodenum. Due to its rarity, the diagnosis of Bouveret's syndrome is often delayed and causes a high morbidity and mortality rate.

Case Summary: A 93-year-old female presented with worsening pain in the right upper abdomen and vomiting. Read More

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http://dx.doi.org/10.3748/wjg.v26.i19.2458DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7243648PMC

Supplementing neonatal Jersey calves with a blend of probiotic bacteria improves the pathophysiological response to an oral Salmonella enterica serotype Typhimurium challenge.

J Dairy Sci 2020 May 28. Epub 2020 May 28.

MB Nutritional Sciences LLC, Lubbock, TX 79403; Department of Veterinary Science, Texas Tech University, Lubbock 79409.

The objectives of the current study were to determine the effects of supplementing a blend of probiotic bacteria (Provida Calf, MB Nutritional Sciences, Lubbock, TX) on the pathophysiological response to an oral Salmonella enterica serotype Typhimurium challenge in neonatal Jersey calves. Twenty-four Jersey bull calves within 24 h of birth were acquired from a local calf ranch, blocked by total serum protein and initial body weight, and randomly assigned to 1 of 3 treatments (n = 8). Calves were assigned to either (1) Control (CON); base milk replacer, (2) Control + Salmonella Typhimurium (CON+ST); base milk replacer and challenged with Salmonella Typhimurium on d 7; or (3) Provida Calf probiotics + Salmonella Typhimurium (PRO+ST); same milk replacer supplemented with a proprietary blend of Lactobacillus casei and Enterococcus faecium strains and challenged with Salmonella Typhimurium on d 7. Read More

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http://dx.doi.org/10.3168/jds.2019-17480DOI Listing

Effects of broiler genetic strain and dietary amino acid reduction on (part I) growth performance and internal organ development.

Poult Sci 2020 Jun 11;99(6):3266-3279. Epub 2020 Apr 11.

Department of Poultry Science, Nutrition and Health Promotion, Mississippi State University, Mississippi State, MS 39762, USA. Electronic address:

Genetic selection in broilers has resulted in improved growth performance, meat yield, and feed conversion efficiency. However, consumers have become increasingly concerned about modern broiler welfare that is related to their rapid growth rate, which may be alleviated by nutrient dilution. This study was conducted to investigate the effects of dietary amino acid (AA) reduction on the growth performance and internal organ development of different genetic strains of broilers. Read More

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http://dx.doi.org/10.1016/j.psj.2020.03.024DOI Listing

Identification, tissue characterization, and innate immune role of Angiogenin-4 expression in young broiler chickens.

Poult Sci 2020 Jun 15;99(6):2992-3000. Epub 2020 Apr 15.

Department of Pathology and Microbiology, Atlantic Veterinary College, University of Prince Edward Island, Charlottetown, Prince Edward Island, Canada. Electronic address:

Intestinal epithelial cells are major producers of antimicrobial proteins, which play an important role in innate immunity. In addition to defensins, the Ribonuclease A superfamily includes important antimicrobial proteins involved in host-defense mechanisms in vertebrates. Angiogenin-4 (Ang4), a member of this RNase superfamily, has been demonstrated to be secreted by Paneth cells in mice. Read More

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http://dx.doi.org/10.1016/j.psj.2020.03.022DOI Listing

Feeding of yeast cell wall extracts during a necrotic enteritis challenge enhances cell growth, survival and immune signaling in the jejunum of broiler chickens.

Poult Sci 2020 Jun 8;99(6):2955-2966. Epub 2020 Apr 8.

Department of Animal and Food Sciences, University of Delaware, Newark, DE 19716, USA. Electronic address:

Necrotic enteritis (NE) is one of the most common and costly diseases in the modern broiler industry, having an estimated economic impact of $6 billion dollars annually. Increasing incidents of NE have resulted from restrictions on the use of antibiotic feed additives throughout the broiler industry. As such, finding effective antibiotic alternatives has become a priority. Read More

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http://dx.doi.org/10.1016/j.psj.2020.03.012DOI Listing

Radiation therapy for patients with locally advanced pancreatic cancer: Evolving techniques and treatment strategies.

Curr Probl Cancer 2020 May 21:100607. Epub 2020 May 21.

The University of Texas MD Anderson Cancer Center, Houston, Texas. Electronic address:

Despite ongoing efforts, patients with locally advanced pancreatic cancer (LAPC) continue to have a dismal prognosis. Such tumors are unresectable, and optimal treatment with chemotherapy and/or radiation therapy is still not established. While chemotherapy is conventionally aimed at preventing metastatic spread of disease, radiation therapy acts locally, improving local control which can potentially improve overall survival and most importantly quality of life. Read More

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http://dx.doi.org/10.1016/j.currproblcancer.2020.100607DOI Listing

Surgical outcomes of patients with duodenal vs pancreatic neuroendocrine tumors following pancreatoduodenectomy.

J Surg Oncol 2020 May 29. Epub 2020 May 29.

Division of Surgical Oncology, Wexner Medical Center and James Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio.

Background: To investigate the short- and long-term outcomes of patients undergoing pancreaticoduodenectomy (PD) for duodenal neuroendocrine tumors (dNETs) vs pancreatic neuroendocrine tumors (pNETs).

Method: Patients undergoing PD for dNETs or pNETs between 1997 and 2016 were identified from a multi-institutional database. Overall survival (OS) and recurrence-free survival (RFS) were evaluated. Read More

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http://dx.doi.org/10.1002/jso.25978DOI Listing

Phosphorylation of mouse intestinal basolateral amino acid uniporter LAT4 is controlled by food-entrained diurnal rhythm and dietary proteins.

PLoS One 2020 29;15(5):e0233863. Epub 2020 May 29.

Institute of Physiology and Zurich Center for Integrative Human Physiology (ZIHP), University of Zurich, Zurich, Switzerland.

Adaptive regulation of epithelial transporters to nutrient intake is essential to decrease energy costs of their synthesis and maintenance, however such regulation is understudied. Previously we demonstrated that the transport function of the basolateral amino acid uniporter LAT4 (Slc43a2) is increased by dephosphorylation of serine 274 (S274) and nearly abolished by dephosphorylation of serine 297 (S297) when expressed in Xenopus oocytes. Phosphorylation changes in the jejunum of food-entrained mice suggested an increase in LAT4 transport function during food expectation. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0233863PLOS

Study on the pharmacological character of an insulin-mimetic small molecular compound of vanadyl trehalose.

Physiol Res 2020 May 29. Epub 2020 May 29.

Science College, Nankai University, Tianjin, China.

To investigate the effect of vanadyl trehalose (VT) on oxidative stress and reduced glutathione/glutathione-S-transferase (GSH/GSs) pathway gene expression in mouse gastrointestinal tract, as well as the protective effects of vitamin C (VC) and reduced glutathione (GSH). Thirty male Kunming mice were randomly divided into five groups: control group (group A), VT group (group B), VC + VT group (group C), GSH + VT group (group D) and VC + GSH + VT group (group E). The content of reduced glutathione (GSH) and glutathione peroxidase (GSH-Px) activity and the expressions of glutamate-cysteine ligase catalytic subunit (GCLC), glutathione synthetase (GSS), regulated through glutathione reductase (GSR) and glutathione-S-transferase pi (GSTpi) in stomach and duodenum in vanadyl trehalose treated group were lower than those in group A (P<0. Read More

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Effects of undigested protein-rich ingredients on polarised small intestinal organoid monolayers.

J Anim Sci Biotechnol 2020 18;11:51. Epub 2020 May 18.

1Host Microbe Interactomics Group, Wageningen University & Research, De Elst 1, 6708 WD Wageningen, The Netherlands.

Abstract: Here, we describe the use of monolayers of intestinal epithelial cells derived from intestinal organoids and transcriptomics to investigate the direct effects of dietary protein sources on epithelial function. Mechanically dissociated 3D organoids of mouse duodenum were used to generate a polarized epithelium containing all cell types found in the tissue of origin. The organoid-derived cell monolayers were exposed to 4% (w/v) of 'undigested (non-hydrolysed)-soluble' fraction of protein sources used as feed ingredients [soybean meal (SBM) and casein], or alternative protein sources (spray dried plasma protein, and yellow meal worm), or controls for 6 h prior to RNA isolation and transcriptomics. Read More

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http://dx.doi.org/10.1186/s40104-020-00443-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7232837PMC

Double-balloon endoscopy facilitates efficient endoscopic resection of duodenal and jejunal polyps in patients with familial adenomatous polyposis.

Endoscopy 2020 May 28. Epub 2020 May 28.

Jichi medical University, Department of medicine, Division of gastroenterology, Shimotsuke, Japan.

Background Many patients with familial adenomatous polyposis (FAP) have adenomatous polyps of the duodenum and the jejunum. We aimed to elucidate the long-term outcomes after double-balloon endoscopy (DBE)-assisted endoscopic resection of duodenal and jejunal polyps in patients with FAP. Methods We retrospectively reviewed patients who underwent more than two sessions of endoscopic resection using DBE from August 2004 to July 2018. Read More

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http://dx.doi.org/10.1055/a-1189-9550DOI Listing

Near-infrared fluorescent clip guided gastrectomy: Report of 2 cases (Case reports).

Ann Med Surg (Lond) 2020 Jul 11;55:49-52. Epub 2020 May 11.

Department of Surgery, International University of Health and Welfare Hospital, 537-3, Iguchi, Nasushiobara City, Tochigi, 329-2763, Japan.

Introduction: This is the first report on near-infrared fluorescent (NIRF) clip-guided gastrectomy. The NIRF clip, ZEOCLIP FS, emits NIRF signals when excited. We hypothesized that preoperative placement of the ZEOCLIP FS near a gastric lesion would allow fluorescence laparoscopic localization of the clip, and hence, the lesion, during surgery. Read More

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http://dx.doi.org/10.1016/j.amsu.2020.04.026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7240282PMC

Optimal Dietary Levels of 1-Hydroxycholecalciferol in Broiler Chickens from 1 to 42 Days of Age.

J Poult Sci 2020 Apr;57(2):124-130

Department of Animal Science, College of Life Science, Shangqiu Normal University, Shangqiu, Henan, China.

1-Hydroxycholecalciferol (1-OH-D) is an active vitamin D derivative. In this study, three experiments were conducted to evaluate the optimal dietary levels of 1-OH-D in broiler chickens from 1 to 42 days of age. 1-OH-D levels used were 0, 1. Read More

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http://dx.doi.org/10.2141/jpsa.0190013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7248009PMC

The effect of reduced gastric acid secretion on the gastrointestinal disposition of a ritonavir amorphous solid dispersion in fasted healthy volunteers: an in vivo - in vitro investigation.

Eur J Pharm Sci 2020 May 24:105377. Epub 2020 May 24.

Drug Delivery and Disposition, KU Leuven, Gasthuisberg O&N II, Herestraat 49 - box 921, 3000 Leuven, Belgium. Electronic address:

This paper summarizes efforts to (i) better understand the behavior of amorphous solid dispersions (ASDs) under real-life dosing conditions and (ii) evaluate the capability of in vitro methodologies to capture gastro-intestinal drug disposition. In a first part of the study, five healthy volunteers participated in a two-way crossover trial in which one Norvir® tablet (100 mg ritonavir) was dosed under fasted and fasted + PPI conditions. Gastrointestinal aspirates were collected from both the stomach and duodenum as a function of time to map the gastrointestinal drug disposition of the ritonavir ASD formulation and to evaluate the impact of reduced gastric acid secretion on formulation performance. Read More

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http://dx.doi.org/10.1016/j.ejps.2020.105377DOI Listing

Dietary bioaccumulation potential of silver nanomaterials compared to silver nitrate in wistar rats using an ex vivo gut sac technique.

Ecotoxicol Environ Saf 2020 May 24;200:110745. Epub 2020 May 24.

School of Biological and Marine Sciences, University of Plymouth, Plymouth, United Kingdom. Electronic address:

Chronic dietary bioaccumulation tests with rodents are required for new substances, including engineered nanomaterials (ENMs), in order to provide information on the potential hazards to human health. However, screening tools are needed to manage the diversity of ENMs and alternative methods are desirable with respect to animal welfare. Here, an ex vivo gut sac method was used to estimate the dietary bioaccumulation potential of silver nanomaterials. Read More

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http://dx.doi.org/10.1016/j.ecoenv.2020.110745DOI Listing

A case of triple digestive tract reconstruction in chronic pancreatitis complicated with bile ductal stenosis, duodenal stenosis, and portal vein stenosis: a case report.

Surg Case Rep 2020 May 26;6(1):116. Epub 2020 May 26.

Department of Gastroenterological Surgery, Graduate School of Medicine, Yokohama City University, 3-9 Fukuura, Kanazawa-ku, Yokohama, 236-0004, Japan.

Background: Although endoscopic interventions for chronic pancreatitis are highly developed, surgery for severe complicated cases such as the coexistence of bile duct, duodenum, and portal vein stenosis is a challenging issue for surgeons. In such instances, pancreaticoduodenectomy could lead to massive intraoperative bleeding due to severe collateral veins. A surgical drainage procedure, instead of pancreatic resection, may be a reasonable and safer option in such cases, but the literature on a surgical drainage technique to resolve all obstructions of the pancreatic duct, bile duct, and duodenum at once is limited. Read More

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http://dx.doi.org/10.1186/s40792-020-00872-3DOI Listing

One-to-one relationships between milk miRNA content and protein abundance in neonate duodenum support the potential for milk miRNAs regulating neonate development.

Funct Integr Genomics 2020 May 27. Epub 2020 May 27.

Department of Animal Sciences, Purdue University, 175 South University Street, West Lafayette, IN, 47907-2063, USA.

Breast milk plays an essential role for offspring development; however, there lacks evidence of how specific milk components like nucleic acids mechanistically function to regulate neonate development. Previously, we found that maternal high-fat diet (HFD) not only significantly affected mRNA and miRNA content of the secreted milk transcriptome in mice but also affected the duodenal proteome of suckling pups. Here, we hypothesized that nucleic acids differentially expressed in milk of HFD fed dams are related to differentially abundant proteins in offspring duodenum nursed by HFD dams. Read More

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http://dx.doi.org/10.1007/s10142-020-00743-yDOI Listing

Different Sources of High Fat Diet Induces Marked Changes in Gut Microbiota of Nursery Pigs.

Front Microbiol 2020 7;11:859. Epub 2020 May 7.

Guangdong Provincial Key Laboratory of Animal Nutrition Control, College of Animal Science, South China Agricultural University, Guangzhou, China.

Fat is one of the most important nutrients which provides concentrated energy and essential fatty acids. High fat diet markedly changes the gut microbial composition in mammals, whereas little is known about the impact of fat type on gut microbiome. This study was to evaluate the effects of fat sources on intestinal microbiota of nursery pigs. Read More

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http://dx.doi.org/10.3389/fmicb.2020.00859DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7221029PMC

Living donor liver retransplantation for primary non-function of liver graft following multivisceral transplantation in a pediatric patient.

Ann Hepatobiliary Pancreat Surg 2020 May;24(2):198-202

Division of Pediatric Surgery, Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

Multivisceral organ transplantation (MVOT) includes transplantation of three or more abdominal organs, generally including the small bowel, duodenum, stomach, liver, pancreas, and colon. We here presented the detailed procedures of repeat living donor liver transplantation for primary non-function of the first liver graft following MVOT in a pediatric patient. A 6-year-old girl with chronic intestinal pseudo-obstruction underwent MVOT with 5-year-old donor organs. Read More

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http://dx.doi.org/10.14701/ahbps.2020.24.2.198DOI Listing

Open-Label Crossover Oral Bioequivalence PK Comparison for a 3-Day Loading Dose Regimen and 15-Day Steady-State Administration of SUBA™-Itraconazole and Conventional Itraconazole Capsules in Healthy Adults.

Antimicrob Agents Chemother 2020 May 26. Epub 2020 May 26.

Department of Medical Affairs, Mayne Pharma, Inc., Raleigh, NC

SUBA™-itraconazole (S-ITZ) which releases drug in the duodenum compared to conventional ITZ (C-ITZ) in the stomach were compared in two PK studies: a 3-day loading dose and a 15-day steady-state. These were crossover, oral bioequivalence studies under fed conditions in healthy adult volunteers. In the loading dose study, C-ITZ (2x100 mg) and S-ITZ (2x65 mg) were administered TID for 3 days and once on day 4 (N=15). Read More

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http://dx.doi.org/10.1128/AAC.00400-20DOI Listing

Repair of a perforated duodenal diverticulum using intraduodenal suture in 94 year old woman: A case report.

Int J Surg Case Rep 2020 May 16;71:163-167. Epub 2020 May 16.

Department of Surgery, Tokushima Red Cross Hospital, Tokushima, Japan.

Introduction: In case of gastrointestinal diverticula, the duodenal type is quite frequent; duodenum is the second most common site for diverticula following the colon (Glener et al., 2016). However, duodenal diverticular perforation is rare, so the appropriate surgical treatment for this condition is yet unclear (Simoes et al. Read More

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http://dx.doi.org/10.1016/j.ijscr.2020.04.083DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7248578PMC

[Endoscopic features and clinical correlation analysis of 24 patients with Cronkhite-Canada syndrome].

Zhonghua Yi Xue Za Zhi 2020 May;100(20):1562-1566

Department of Gastroenterology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, China.

To clarify the endoscopic changes prior to corticosteroid therapy in Cronkhite-Canada syndrome (CCS) patients and to explore the correlation between endoscopic features and clinical characteristics. A total of 24 CCS patients who were hospitalized in Peking Union Medical College Hospital from January 1999 to June 2019 and underwent gastroscopy and colonoscopy before corticosteroid therapy were retrospectively enrolled. The endoscopic images were re-interpreted. Read More

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http://dx.doi.org/10.3760/cma.j.cn112137-20191125-02556DOI Listing

Cutting the edge between cancerogenesis and organogenesis of the pancreatic endocrine lineage allocation-comprehensive review of the genes Synaptotagmin 13 and 533041C22 Rik in epithelial-to-mesenchymal transition.

Cancer Metastasis Rev 2020 May 24. Epub 2020 May 24.

TUM München, Arcisstraße 21, 80333, Munich, Germany.

In the past years, a multitude of studies has been published in the field of pancreatic organogenesis to interrogate the critical regulators of endocrine lineage segregation. Preliminary, transcription factors are guiding the transcriptional hierarchy of the endocrine specified cells, underpinning the importance of open chromatin formation. Signaling pathways either inhibit or accelerate the transcriptional landscape of pancreatic organogenesis. Read More

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http://dx.doi.org/10.1007/s10555-020-09897-4DOI Listing

Effect of Corn Particle Size on the Particle Size of Intestinal Digesta or Feces and Nutrient Digestibility of Corn-Soybean Meal Diets for Growing Pigs.

Animals (Basel) 2020 May 18;10(5). Epub 2020 May 18.

The State Key Laboratory of Animal Nutrition, Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing 100193, China.

This study was conducted to evaluate the effect of corn particle size on the particle size of intestinal digesta or feces and nutrient digestibility of corn-soybean meal diets. Twenty-four growing barrows (initial BW: 21.9 ± 1. Read More

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http://dx.doi.org/10.3390/ani10050876DOI Listing

"U-shaped" mesoportal jump graft to manage portal vein thrombosis during liver transplantation: A case report.

Int J Surg Case Rep 2020 May 15;71:73-77. Epub 2020 May 15.

General Surgery 2U - Liver Transplant Unit, A.O.U. Città della Salute e della Scienza di Torino, University of Torino, Torino, Italy. Electronic address:

Introduction: Once considered a contraindication to liver transplantation, portal vein thrombosis still represents a significant challenge to the liver transplant surgeon. Yerdel grade 3 thrombosis is usually managed by interposing a donor iliac vein jump graft between graft portal vein and distal superior mesenteric vein. Venous patch is normally placed in a retrogastric position to avoid its kinking. Read More

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http://dx.doi.org/10.1016/j.ijscr.2020.04.098DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7240169PMC

A novel murine model of reversible bile duct obstruction demonstrates rapid improvement of cholestatic liver injury.

Physiol Rep 2020 May;8(10):e14446

Department of Surgery, Northwestern University, Chicago, IL, USA.

There are limited murine models of cholestatic liver diseases characterized by chronic biliary obstruction and resumption of bile flow. While murine bile duct ligation (BDL) is a well-established model of obstructive cholestasis, current models of BDL reversal (BDLR) alter biliary anatomy. We aimed to develop a more physiologic model of BDLR to evaluate the time course and mechanism for resolution of hepatic injury after biliary obstruction. Read More

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http://dx.doi.org/10.14814/phy2.14446DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7243199PMC

and effects of on gastrointestinal motility in rats.

Iran J Basic Med Sci 2020 Mar;23(3):383-389

Department of Pharmacy, College of Chemical Engineering, Qingdao University of Science & Technology, Qingdao, China.

Objectives: is widely distributed along the Bohai coast and consumed as an edible plant by native residents. We have found surprisingly that extracts promoted gastrointestinal motility in mice previously. In the present study, effects of on gastrointestinal motility in rats and its underlying mechanism were explored. Read More

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http://dx.doi.org/10.22038/IJBMS.2019.40613.9605DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7229513PMC

Ultrasonographic evaluation of cholecystoduodenostomy sites in six cats.

J Feline Med Surg 2020 May 21:1098612X20921062. Epub 2020 May 21.

Internal Medicine, Tufts University Cummings School of Veterinary Medicine, North Grafton, MA, USA.

Case Series Summary: This case series describes the postoperative ultrasonographic findings in six cats that underwent a cholecystoduodenostomy as treatment for extrahepatic biliary obstruction. The surgery site was identified in all six cats, most often within the right cranial abdomen as a thick-walled gall bladder, with a broad-based connection to the descending duodenum. Postoperatively, the biliary tree often remained distended, similar to its preoperative appearance. Read More

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http://dx.doi.org/10.1177/1098612X20921062DOI Listing