33,514 results match your criteria Duodenal Ulcers


Delayed Management of Zollinger-Ellison Syndrome in a Noncompliant Patient.

Cureus 2020 Jun 6;12(6):e8471. Epub 2020 Jun 6.

Department of Gastroenterology and Hepatology, Carol Davila University of Medicine and Pharmacy, Floreasca Emergency Hospital, Bucharest, ROU.

We present a case of a 60-year-old male diagnosed with Zollinger-Ellison syndrome (ZES) after a protracted multicentric workup for chronic diarrhea and unexplained weight loss. ZES is intrinsically difficult to diagnose due to nonspecific symptoms, which are mimicked by other more frequent pathologies, such as peptic ulcer disease secondary to Helicobacter pylori or nonsteroidal anti-inflammatory drugs. The diagnostic challenge can be further complicated by patient noncompliance, resulting in delayed management and unnecessary health care. Read More

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http://dx.doi.org/10.7759/cureus.8471DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7336717PMC

Low Risk for Marginal Ulcers in Duodenal Switch and Gastric Bypass in a Well-Defined Cohort of 472 Patients.

Obes Surg 2020 Jul 8. Epub 2020 Jul 8.

Department of Surgical Sciences, Uppsala University, SE-751 85, Uppsala, Sweden.

Purpose: Marginal ulcer (MU) is well-known complication in bariatric surgery. Several studies are available in Roux-en-Y gastric bypass (RYGBP), while data on the incidence in duodenal switch (DS) is limited. We aimed to compare the incidence of MU between DS and RYGBP in a well-defined cohort and to identify associative factors. Read More

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http://dx.doi.org/10.1007/s11695-020-04822-8DOI Listing

Neratinib-Induced Duodenal Ulcer: A Case Report.

Breast Cancer (Auckl) 2020 23;14:1178223420935871. Epub 2020 Jun 23.

Wilmot Cancer Institute, University of Rochester, Rochester, NY, USA.

We report a case of a 37-year-old woman who developed a duodenal ulcer while receiving adjuvant neratinib for HER2 positive breast cancer. The clinical course of abdominal pain was strongly correlated with the use of neratinib. An esophagogastroduodenoscopy (EGD) was performed and confirmed the diagnosis of a large duodenal ulcer. Read More

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http://dx.doi.org/10.1177/1178223420935871DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315670PMC

Adapted ERAS Pathway Versus Standard Care in Patients Undergoing Emergency Small Bowel Surgery: a Randomized Controlled Trial.

J Gastrointest Surg 2020 Jul 6. Epub 2020 Jul 6.

Department of Surgery, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry, 605006, India.

Background: Emergency laparotomy for small bowel pathologies comprises a significant number of all emergency surgeries. Application of evidence-based adapted enhanced recovery after surgery (ERAS) protocol can potentially improve the perioperative outcome in these procedures.

Aims: To determine the feasibility, safety, and efficacy of adapted ERAS pathway in emergency small bowel surgery. Read More

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http://dx.doi.org/10.1007/s11605-020-04684-6DOI Listing
July 2020
2.798 Impact Factor

Minimal weight loss related to a short fasting period causes superior mesenteric artery syndrome in a patient with amyotrophic lateral sclerosis: A case report.

Medicine (Baltimore) 2020 Jul;99(27):e20571

Department of Physical Medicine and Rehabilitation, Jeonbuk National University Medical School.

Introduction: Superior mesenteric artery syndrome (SMAS) is rare cause of small bowel obstruction and is characterized by an extrinsic vascular compression of the duodenum. The most common cause of SMAS is known as rapid and significant weight loss.

Patient Concerns: A 61-year-old man who was diagnosed with amyotrophic lateral sclerosis and maintained a stable diet before admission. Read More

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http://dx.doi.org/10.1097/MD.0000000000020571DOI Listing

Accuracy of ICD-9 codes in identifying patients with peptic ulcer and gastrointestinal hemorrhage in the regional healthcare administrative database of Umbria.

PLoS One 2020 6;15(7):e0235714. Epub 2020 Jul 6.

Health Planning Service, Regional Health Authority of Umbria, Perugia, Italy.

Background: Peptic ulcer is a widespread disease, frequently complicated by perforation and bleeding. Administrative databases are useful tool to perform epidemiological and drug utilization studies, but they need a validation process based on a comparison with the original data contained in the medical charts. Our aim was to evaluate the accuracy of the ICD-9 codes in identifying patients with peptic ulcer and gastrointestinal hemorrhage in the regional administrative database of Umbria. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0235714PLOS

Gastrointestinal Stromal Tumor: GIST Another Duodenal Ulcer.

Ochsner J 2020 ;20(2):236-238

Division of Gastroenterology and Hepatology, University of Alabama at Birmingham, Birmingham, AL.

Gastrointestinal stromal tumors (GISTs), although exceedingly rare, are the most common mesenchymal tumors in the gastrointestinal (GI) tract. GISTs are often asymptomatic; approximately 10% are found incidentally on imaging or endoscopy for other indications, although GI bleeding, intestinal obstruction, and perforation can occur. We present a case of upper GI bleeding from a duodenal GIST. Read More

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http://dx.doi.org/10.31486/toj.18.0167DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7310177PMC
January 2020

Valentino's Syndrome (with Retroperitoneal Ulcer Perforation): A Rare Clinico-Anatomical Entity.

Am J Case Rep 2020 Jul 2;21:e922647. Epub 2020 Jul 2.

Department of General Surgery, Agios Dimitrios General Hospital, Thessaloniki, Greece.

BACKGROUND In the emergency department pain in the right lower quadrant is a frequent finding and is related to a wide variety of diseases, the most common of which is acute appendicitis. An unusual presentation of pain in the right iliac fossa is due to perforation of a duodenal peptic ulcer. The fluid that originates from the perforated ulcer moves through the paracolic sulcus to the right iliac fossa and causes irritation of the peritoneum and even chemical peri-appendicitis, thereby imitating all the usual causes of pain in the right lower quadrant. Read More

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http://dx.doi.org/10.12659/AJCR.922647DOI Listing

[The efficacy and safety of quadruple therapy without bismuth (concomitant therapy) in the treatment of patients with Helicobacter pylori - associated gastric and duodenal peptic ulcer disease].

Ter Arkh 2019 Aug 15;91(8):28-33. Epub 2019 Aug 15.

Yevdokimov Moscow State University of Medicine and Dentistry.

Aim: Evaluation of the efficacy and safety of quadrupletherapy without bismuth (concomitant therapy) in patients with Helicobacter pylori - associated gastric ulcer and duodenal ulcer in the framework of a comparative research in the population of patients in Russia.

Materials And Methods: A prospective randomized trial was conducted, which included 210 patients with H. pylori - associated gastric/duodenal ulcer without complications. Read More

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http://dx.doi.org/10.26442/00403660.2019.08.000382DOI Listing

Gastric xanthelasma may be a warning sign of intestinal metaplasia: A cross‑sectional study.

Oncol Rep 2020 Jun 19. Epub 2020 Jun 19.

Department of Gastroenterology, Ruijin Hospital North, Shanghai Jiaotong University School of Medicine, Shanghai 201801, P.R. China.

Certain conflicting conclusions have been drawn that gastric xanthelasma is related to H. pylori, atrophic gastritis, intestinal metaplasia, and early gastric cancer. The aim of this study was to examine the relationship between gastric xanthelasma and upper gastrointestinal (GI) endoscopic or pathological features. Read More

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http://dx.doi.org/10.3892/or.2020.7651DOI Listing

A Case of IgG4-related Disease Manifesting as Gastroduodenal Ulcer Diagnosed by an Endoscopic Biopsy.

Intern Med 2020 Jun 23. Epub 2020 Jun 23.

Department of Gastroenterology, National Hospital Organization Asahikawa Medical Center, Japan.

A 26-year-old man was admitted to our hospital due to upper abdominal pain. He had previously been diagnosed with gastroduodenal ulcer at 23 and 25 years old and had been treated with proton-pump inhibitors. Endoscopic hemostasis and a biopsy were performed on the hemorrhagic gastroduodenal ulcers. Read More

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http://dx.doi.org/10.2169/internalmedicine.4483-20DOI Listing

Endoscopic naso-biliary and -pancreatic duct drainage for refractory post-bulbar duodenal ulcer bleeding.

Dig Endosc 2020 Jun 23. Epub 2020 Jun 23.

Department of Hepatobiliary Pancreatic Oncology, Osaka International Cancer Institute, Osaka, Japan.

Bleeding peptic ulcer is usually manageable with endoscopic hemostasis and gastric acid suppressants; however, recurrent bleeding sometimes occurs, especially in patients with comorbidities . A woman in her 60s who had received bone marrow transplantation for mycosis fungoides 2 months earlier received 30 mg methylprednisolone for graft-versus-host disease (GVHD). She presented with anemia and melena, and emergency esophagogastroduodenoscopy (EGD) revealed a bleeding ulcer next to the peri-ampullary diverticulum. Read More

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http://dx.doi.org/10.1111/den.13781DOI Listing

Abdominal Surgery in Patients with COVID-19: Detection of SARS-CoV-2 in Abdominal and Adipose Tissues.

Ann Surg 2020 Jun 16. Epub 2020 Jun 16.

Digestive Disease and Surgery Institute, Cleveland Clinic, Cleveland, Ohio, USA.

: Multiple tissue samples were obtained during emergent abdominal surgery in four patients with coronavirus disease 2019 (COVID-19) to examine for tissue involvement by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The first patient underwent a laparoscopic cholecystectomy for gallbladder empyema and died from severe respiratory failure. The second patient with Crohn's disease underwent emergent laparotomy for a perforation in the terminal ileum and recovered. Read More

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http://dx.doi.org/10.1097/SLA.0000000000004165DOI Listing

Primary left ventricular neuroendocrine tumor in a middle-aged female: a case report.

Ann Transl Med 2020 May;8(10):653

Department of Radiology, West China Hospital, Sichuan University, Chengdu 610041, China.

Primary neuroendocrine tumors (NETs) in the heart are exceptionally rare. Here, we report a case found at our hospital of a 51-year-old woman with a primary left ventricular NET. The patient presented with non-causal recurrent diarrhea for 2 years, abdominal pain, and vomiting. Read More

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http://dx.doi.org/10.21037/atm-20-3049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7290606PMC

Endoscopic projection of the gastroduodenal artery: Anatomical implications for bleeding management.

Ann Anat 2020 Jun 18;232:151560. Epub 2020 Jun 18.

University Clinic for Visceral, General and Transplant Surgery, University Hospital Tübingen, Tübingen, Germany. Electronic address:

Introduction: Peptic ulcers account for 50% of upper gastrointestinal bleeding incidents. Bleedings from large vessels, such as the gastroduodenal artery, are associated with increased mortality. Ulcers located on the posterior wall of the duodenum show the highest risk for erosion of the gastroduodenal artery. Read More

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http://dx.doi.org/10.1016/j.aanat.2020.151560DOI Listing

Changing pattern of perforated PUD: Are NSAIDs to be blamed?

Turk J Surg 2019 Jun 13;35(2):105-110. Epub 2019 Jun 13.

Nnamdi Azikiwe Üniversitesi Eğitim Hastanesi, Cerrahi Bölümü, Nnewi, Nijerya.

Objectives: This study aimed to determine if there is association between gastric perforation and non-steroidal anti-inflammatory drugs (NSAIDs) abuse in patients presenting with perforated peptic ulcer disease (PPUD).

Material And Methods: The data were collected retrospectively from May 2011 to May 2015 and then prospectively until December 2017. Sixty patients diagnosed with PPUD on exploratory laparotomy were evaluated. Read More

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http://dx.doi.org/10.5578/turkjsurg.4145DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6796067PMC

Management of Gastroduodenal Artery Pseudoaneurysm Rupture With Duodenal Ulcer Complicated by Coil Migration.

ACG Case Rep J 2020 Apr 29;7(4):e00347. Epub 2020 Apr 29.

Department of Internal Medicine, Internal Medicine at Northwell Health at Mather Hospital, Port Jefferson, NY.

Rupture of visceral artery aneurysms or visceral artery pseudoaneurysms is an unusual cause of upper gastrointestinal bleeding. Although most visceral artery aneurysms and visceral artery pseudoaneurysms occur in the splenic artery or hepatic artery, they can rarely occur in the gastroduodenal artery. These are at high risk for rupture, with a 40%-70% mortality. Read More

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http://dx.doi.org/10.14309/crj.0000000000000347DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7224706PMC

Prevalence of non Helicobacter pylori gastric Helicobacters in Iranian dyspeptic patients.

BMC Gastroenterol 2020 Jun 16;20(1):190. Epub 2020 Jun 16.

Department of Biology, Qaemshahr Branch, Islamic Azad University, Qaemshahr, Iran.

Background: Non Helicobacter pylori gastric Helicobacters (NHPGHs) are associated with a range of upper gastrointestinal symptoms, histologic and endoscopic findings. For the first time in Iran, we performed a cross-sectional study in order to determine the prevalence of five species of NHPGHs in patients presenting with dyspepsia.

Methods: The participants were divided into H. Read More

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http://dx.doi.org/10.1186/s12876-020-01331-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7298804PMC

Helicobacter Pylori Infection in Pediatric Patients Living in Europe: Results of the EuroPedHP Registry 2013-2016.

J Pediatr Gastroenterol Nutr 2020 Jun 11. Epub 2020 Jun 11.

Pediatric Gastroenterology, Kaplan Medical Centre, Rehovot, Israel.

Objectives: To assess clinical presentation, endoscopic findings, antibiotic susceptibility and treatment success of Helicobacter pylori (H. pylori) infected pediatric patients.

Methods: Between 2013-2016, 23 pediatric hospitals from 17 countries prospectively submitted data on consecutive H. Read More

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http://dx.doi.org/10.1097/MPG.0000000000002816DOI Listing

A Rare Presentation of Choledochoduodenal Fistula Due to Ovarian Cancer Metastasis.

J Investig Med High Impact Case Rep 2020 Jan-Dec;8:2324709620934680

Augusta University Medical Center, Medical College of Georgia, Augusta, GA, USA.

Choledochoduodenal fistula (CDF) is an abnormal communication between the common bile duct and the duodenum. It accounts for about 5% to 25% of the total biliary fistulas and is usually due to a perforated duodenal ulcer, choledocholithiasis, and complications secondary to tuberculosis or could be iatrogenic. Primary intrabilliary tumors usually cause obstructive jaundice and rarely biliary metastasis arising from other organs like colon, breast, and lungs can cause obstructive jaundice. Read More

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http://dx.doi.org/10.1177/2324709620934680DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7298208PMC

Eosinophilic Gastroenteritis-associated Duodenal Ulcer Successfully Treated with Crushed Budesonide.

Intern Med 2020 Jun 15. Epub 2020 Jun 15.

Departments of Gastroenterology, National Hospital Organization Hakodate National Hospital, Japan.

Eosinophilic gastroenteritis (EGE)-associated duodenal ulcer is rare and its endoscopic and pathological features remain poorly described. A 15-year-old boy was referred to our hospital for further examination and treatment of duodenal ulcer. Esophagogastroduodenoscopy (EGD) revealed two A2-stage duodenal ulcers on the duodenal bulb. Read More

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http://dx.doi.org/10.2169/internalmedicine.4706-20DOI Listing

Inverse time trends of peptic ulcer and reflux esophagitis show significant association with reduced prevalence of infection.

Ann Med 2020 Jun 22:1-9. Epub 2020 Jun 22.

Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.

Recent prevalence and trends of gastric/duodenal ulcer (GU/DU) and reflux esophagitis (RE) are inadequate. We reviewed the records of consecutive 211,347 general population subjects from 1991 to 2015. During the 25 years, the prevalence of GU and DU has gradually decreased (from 3. Read More

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http://dx.doi.org/10.1080/07853890.2020.1782461DOI Listing
June 2020
3.886 Impact Factor

Over-the-Scope Clip to the Rescue! A Novel Tool for Refractory Acute Nonvariceal Upper Gastrointestinal Hemorrhage.

Case Rep Gastroenterol 2020 May-Aug;14(2):261-270. Epub 2020 May 12.

Department of Gastroenterology, Staten Island University Hospital, Northwell Health, Staten Island, New York, USA.

Nonvariceal upper gastrointestinal hemorrhage (NVUGIH) is more prevalent than lower gastrointestinal hemorrhage and carries a high risk of mortality in the elderly, especially those with significant cardiovascular comorbidities. Traditional endoscopic methods, such as through-the-scope clips, electrocautery, and epinephrine injection, are frequently used to control these bleeds; however, they carry a 10% risk of rebleeding, and this itself carries a mortality risk of 36%. The larger over-the-scope clips (OTSC) that were initially used for the closure of fistulas and perforations are now gradually being implemented to manage NVUGIH. Read More

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http://dx.doi.org/10.1159/000507610DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7265719PMC

Bacterial colonization of the stomach and duodenum in a Swedish population with and without proton pump inhibitor treatment.

JGH Open 2020 Jun 1;4(3):405-409. Epub 2019 Oct 1.

Department of Surgery South Älvsborg Hospital Borås Sweden.

Background And Aim: Microbial contamination of the abdominal cavity is a serious concern during transgastric endoscopic interventions and perforations, particularly in patients who have inhibited gastric acid secretion due to treatment with proton pump inhibitors (PPIs).The aim of this study was to investigate the gastric and duodenal bacterial flora in patients with and without PPI treatment.

Methods: Patients referred for gastroscopy, without recent antibiotic treatment, were eligible for inclusion. Read More

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http://dx.doi.org/10.1002/jgh3.12265DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7273737PMC

Colonization by and of Antral Biopsy Specimens from Gastritis Patients Uninfected with .

Infect Drug Resist 2020 13;13:1411-1417. Epub 2020 May 13.

Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Purpose: Roles and incidence of some microorganisms that transiently or permanently colonize the human stomach are still unknown despite advances in gastroenterology. We aimed to examine the incidence of four microorganisms, , and , in the antral biopsy specimens of patients with gastroduodenal conditions.

Patients And Methods: Patients (67 females, 33 males; mean age = 49. Read More

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http://dx.doi.org/10.2147/IDR.S254967DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7231751PMC

Analysis of Somatostatin-Secreting Gastric Delta Cells according to Upper Abdominal Symptoms and Infection in Children.

Pediatr Gastroenterol Hepatol Nutr 2020 May 8;23(3):243-250. Epub 2020 May 8.

Department of Pediatrics, Hanyang University College of Medicine, Seoul, Korea.

Purpose: Gastric delta cells (D-cells), which are somatostatin-secreting cells, are the main paracrine inhibitor of acid secretion. The number of D-cells was studied in children presenting with upper gastrointestinal (UGI) disease.

Methods: We retrospectively investigated the number of D-cells in the gastric body and antrum through immunofluorescence examinations according to symptoms, endoscopic findings, and infection in 75 children who visited Hanyang University Hospital Pediatrics. Read More

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http://dx.doi.org/10.5223/pghn.2020.23.3.243DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7231749PMC

Primary laparoscopic approach to repair perforated peptic ulcer. A retrospective cohort study.

Minerva Chir 2020 May 26. Epub 2020 May 26.

Department of Surgery, University of Modena and Reggio Emilia, AOU Policlinico of Modena, Modena, Italy.

Background: Perforated peptic ulcer is a serious complication of peptic ulcer disease and carries high risk for morbidity and mortality. Although the incidence of peptic ulcer disease has decreased in recent decades, the percentage of patients with perforated peptic ulcer requiring emergency surgery remains constant. The use of laparoscopic management as a first choice for the treatment of the perforation is growing but is not routine in many centers. Read More

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http://dx.doi.org/10.23736/S0026-4733.20.08287-5DOI Listing

Hospitalizations for peptic ulcer disease in China: Current features and outcomes.

J Gastroenterol Hepatol 2020 May 25. Epub 2020 May 25.

Department of Epidemiology and Biostatistics, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing, China.

Background And Aim: Rates and outcomes of hospitalizations for peptic ulcer disease (PUD) are unknown in mainland China. We aimed to describe characteristics and treatments of PUD inpatients in secondary and tertiary care hospitals registered in the national Health Statistics and Information Reporting System in 2015 and to explore factors related to inpatient outcomes.

Methods: We retrieved and validated PUD hospitalization data from 4441 hospitals reporting to Health Statistics and Information Reporting System in 2015. Read More

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http://dx.doi.org/10.1111/jgh.15119DOI Listing
May 2020
3.504 Impact Factor

An Emergency Surgery in Severe Case Infected by COVID-19 With Perforated Duodenal Bulb Ulcer.

Ann Surg 2020 07;272(1):e35-e37

Department of Radiology, The Second Xiangya Hospital, Central South University, No.139 Middle Renmin Road, Changsha, Hunan, P. R. China.

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http://dx.doi.org/10.1097/SLA.0000000000003958DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7268851PMC
July 2020
8.327 Impact Factor

Impact of Body Mass Index on Gastrointestinal Disorders: A Cross-sectional Study in a Pakistani Population.

Cureus 2020 Apr 18;12(4):e7722. Epub 2020 Apr 18.

Miscellaneous, Darul Sehat Hospital, Karachi, PAK.

Background:  The prevalence of obesity is on the rise globally. Pakistan ranks ninth out of 188 countries in terms of obesity. Literature regarding any potential role of obesity in gastrointestinal manifestations is limited. Read More

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http://dx.doi.org/10.7759/cureus.7722DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7233932PMC

Optimization of Thymoquinone-Loaded Coconut Oil Nanostructured Lipid Carriers for the Management of Ethanol-Induced Ulcer.

AAPS PharmSciTech 2020 May 17;21(5):137. Epub 2020 May 17.

Department of Pharmaceutics, Faculty of Pharmacy, King Abdulaziz University, P.O.Box: 80260, Jeddah, 21589, Saudi Arabia.

In the global incidence of peptic ulcer, with the associated rates of hospitalizations and mortality are increasing, in the United States, peptic ulcer disease affects approximately 4.6 million people annually, with an estimated 10% of the US population having evidence of a duodenal ulcer. The present research aims to find a novel treatment for ethanol induced ulcer by loading thymoquinone (TQ) on a nanostructured lipid carrier (NLC), using Compritol® 888 and coconut oil. Read More

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http://dx.doi.org/10.1208/s12249-020-01693-1DOI Listing
May 2020
1.776 Impact Factor

Hyponatremia presenting with hourly fluctuating urine osmolality.

Endocrinol Diabetes Metab Case Rep 2020 May 13;2020. Epub 2020 May 13.

Department of Nephrology, St. Luke's International Hospital, Tokyo, Japan.

Summary: The etiology of hyponatremia is assessed based on urine osmolality and sodium. We herein describe a 35-year-old Asian man with pulmonary tuberculosis and perforated duodenal ulcer who presented with hyponatremia with hourly fluctuating urine osmolality ranging from 100 to 600 mosmol/kg, which resembled urine osmolality observed in typical polydipsia and SIADH simultaneously. Further review revealed correlation of body temperature and urine osmolality. Read More

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http://dx.doi.org/10.1530/EDM-19-0155DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7274548PMC

An extremely rare case of nivolumab-associated macroscopic duodenitis with spontaneous regression.

Respirol Case Rep 2020 Jul 11;8(5):e00582. Epub 2020 May 11.

Department of Respiratory Medicine Kyorin University School of Medicine Tokyo Japan.

An 82-year-old man was presented to our hospital due to epigastric and right hypochondrial pain 17 weeks after the initiation of intravenous treatment with nivolumab for recurrent lung adenocarcinoma as multiple lung and sternal metastases. Urgent gastroscopy revealed macroscopic duodenitis such as severe erythema, oedema, black-coloured erosions, and ulcers located throughout the second portion of the duodenum, which was confirmed by abdominal computed tomography as circumferential thickening of the duodenal wall. Those lesions were pathologically considered as non-specific inflammation and spontaneously disappeared within a month, suggesting nivolumab-induced immune-related adverse events. Read More

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http://dx.doi.org/10.1002/rcr2.582DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7214783PMC

Stereotactic body radiation therapy in the treatment of ovarian cancer.

Radiat Oncol 2020 May 13;15(1):108. Epub 2020 May 13.

University of Virginia / Riverside, Radiosurgery Center, Newport News, VA, USA.

Background: This study evaluates the outcomes and toxicity of stereotactic body radiation therapy (SBRT) in ovarian cancer.

Methods: This retrospective analysis considered all patients treated with SBRT from 2009 to 2018 with a primary ovarian tumor. Follow-up included PET-CT and CT scans at 2-3 month intervals. Read More

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http://dx.doi.org/10.1186/s13014-020-01564-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7222303PMC

A Rare Presentation of Poorly Differentiated Lung Carcinoma with Duodenal Metastasis and Literature Review.

Case Rep Gastroenterol 2020 Jan-Apr;14(1):186-196. Epub 2020 Apr 21.

Gastroenterology and Hepatology, East Orange Department of Veteran's Affair, East Orange, New Jersey, USA.

Lung cancer is a common malignancy which is frequently found to metastasize to distant sites including bone, liver, and adrenal glands. There are rare reports of metastases to the gastrointestinal (GI) tract, with the duodenum being the most uncommon. We present a rare case of a poorly differentiated lung carcinoma metastasizing to the duodenum. Read More

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http://dx.doi.org/10.1159/000506927DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7204736PMC

Endoscopic findings in hemodialysis patients upon workup for kidney transplantation.

Saudi J Kidney Dis Transpl 2020 Mar-Apr;31(2):388-394

Shiraz Nephro-Urology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

Upper gastrointestinal (GI) abnormality is believed to be higher in patients with end-stage renal disease (ESRD) which can make a big trouble for whom undergo kidney transplant. We conducted this study to assess upper GI findings of patients with ESRD. In the present retrospective study we recorded upper GI endoscopy results in hemodialysis patients who were candidate for renal transplantation during a 10-year period. Read More

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http://dx.doi.org/10.4103/1319-2442.284013DOI Listing

[Analysis of endoscopic screening compliance and related factors among high risk population of upper gastrointestinal cancer in urban areas of Henan Province from 2013 to 2017].

Zhonghua Yu Fang Yi Xue Za Zhi 2020 May;54(5):523-528

Office for Cancer Control and Research, Henan Cancer Hospital/The Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou 450008, China.

To study the compliance of endoscopic screening for high-risk population of upper gastrointestinal cancer and relevant factors in urban areas of Henan Province, 2013-2017. The study participants were from the Cancer Screening Program in Urban Henan Province, China. From October 2013 to October 2017, 43 423 residents, who were evaluated as high-risk population for upper gastrointestinal cancer, were recruited from Zhengzhou, Zhumadian and Anyang. Read More

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http://dx.doi.org/10.3760/cma.j.cn112150-20200304-00238DOI Listing

Gastroduodenal Surgery in Cirrhotic Patients - Case Series and Literature Review.

Chirurgia (Bucur) 2020 Mar-Apr;115(2):220-226

Specific risk factors for gastroduodenal surgery in cirrhotic patients have been identified, which dictates for a more personalized management. The retrospective study was conducted between 2012-2019 on twelve patients (7 cases of duodenal ulcer, 2 cases of gastric ulcer and 3 patients with gastric cancer). We took into account a number of possible factors involved in the unfavorable evolution of patients, based on data published in the literature so far. Read More

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http://dx.doi.org/10.21614/chirurgia.115.2.220DOI Listing

Atypical mesenteroaxial gastric volvulus with wandering spleen as a late complication of vagotomy and pyloromyotomy for peptic duodenal ulcer.

ANZ J Surg 2020 May 5. Epub 2020 May 5.

General and Digestive Surgery, General Hospital of Catalunya, Barcelona, Spain.

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http://dx.doi.org/10.1111/ans.15966DOI Listing

[Endoscopic treatment of gastroduodenal perforations].

Khirurgiia (Mosk) 2020 (4):61-64

Sklifosovsky Research Institute of Emergency Care of the Moscow Healthcare Department, Moscow, Russia.

A 93-year-old patient underwent endoscopic treatment of perforated duodenal ulcer after previous laparoscopic suturing complicated by failure of sutured defect. A self-expanding nitinol stent with partial polyurethane coating was used. Positive effect of the treatment was noted. Read More

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http://dx.doi.org/10.17116/hirurgia202004161DOI Listing

Vonoprazan Fumarate for the Treatment of Gastric Ulcers: A Short Review on Emerging Data.

Clin Exp Gastroenterol 2020 15;13:99-104. Epub 2020 Apr 15.

Division of Gastroenterology, Department of Surgery, Oncology and Gastroenterology, University of Padua, Padua, Italy.

Potassium-competitive acid blockers (P-CABs), such as vonoprazan, represent a novel and heterogeneous class of drugs that competitively block the potassium binding site of gastric H/K ATPase, thus potentially overcoming the limitations of proton-pump inhibitors. Different studies evaluated the efficacy of vonoprazan versus proton-pump inhibitors (PPIs) for the treatment of acid-related disorders, and, therefore, P-CABs present the same indications of PPIs: gastroesophageal reflux disease, gastric and duodenal ulcer healing, management of upper gastrointestinal bleeding, non-steroidal anti-inflammatory drug (NSAID)-associated ulcers and eradication therapy. The aim of this review was to evaluate the role of vonoprazan for the treatment of peptic ulcer disease (PUD) and the management of gastric ulcer occurring after endoscopic submucosal dissection (ESD). Read More

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http://dx.doi.org/10.2147/CEG.S228352DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7169470PMC

Sociodemographic characteristics and clinical risk factors of Helicobacter pylori infection and antibiotic resistance in the Eastern Black Sea region of Turkey.

Turk J Gastroenterol 2020 Mar;31(3):221-233

Department of Gastroenterology, Karadeniz Technical University School of Medicine, Trabzon, Turkey.

Background/aims: The aim of this study was to assess the clinical and sociodemographic risk factors of Helicobacter pylori infection and antibiotic resistance in the eastern Black Sea region of Turkey.

Materials And Methods: In total, 344 patients with dyspeptic symptoms who completed an extended questionnaire were enrolled in the study. Diagnosis of H. Read More

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http://dx.doi.org/10.5152/tjg.2020.18631DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7197933PMC
March 2020
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Post-Treatment Ulceration and Bleeding After Cyanoacrylate Injection of Duodenal Varices.

ACG Case Rep J 2020 Mar 17;7(3):e00342. Epub 2020 Mar 17.

Division of Gastroenterology and Hepatology, University of Virginia Health Sciences Center, Charlottesville, VA.

We report a case of recurrent gastrointestinal bleeding in the setting of diffuse duodenal and colorectal varices. These varices were secondary to either congenital absence of the portal vein or chronic occlusion of the portal vein leading to cavernous transformation of a collateral network of varices. He was acutely managed with injection of N-butyl-2-cyanoacrylate into a large complex of duodenal varices. Read More

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http://dx.doi.org/10.14309/crj.0000000000000342DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7162136PMC

Fistulas healing. Stable gastric pentadecapeptide BPC 157 therapy.

Curr Pharm Des 2020 Apr 24. Epub 2020 Apr 24.

Departments of Pharmacology and Pathology, School of Medicine, University of Zagreb, Salata 11, POB 916, 10000 Zagreb. Croatia.

This review is focused on the healing of fistulas and stable gastric pentadecapeptide BPC 157. Assuming that the healing of the various wounds is essential also for the gastrointestinal fistulas healing, the healing effect on fistulas in rats, consistently noted with the stable gastric pentadecapeptide BPC 157, may raise several interesting possibilities. BPC 157 is originally an anti-ulcer agent, native to and stable in human gastric juice (for more than 24 h). Read More

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http://dx.doi.org/10.2174/1381612826666200424180139DOI Listing

Rare Complication of Interventional Radiology-guided Arterial Embolization of the Gastroduodenal Artery in the Setting of Acute Gastrointestinal Bleed: Migrated Coils in the Duodenum.

Cureus 2020 Mar 22;12(3):e7365. Epub 2020 Mar 22.

Gastroenterology, State University of New York (SUNY) Upstate Medical University, Syracuse, USA.

A 91-year-old male presented to the emergency room with hemodynamically significant upper gastrointestinal bleeding. The patient underwent an esophagogastroduodenoscopy (EGD), which showed frank blood in the duodenum interfering with the visualization. Hence, the patient underwent urgent interventional radiology (IR)-guided arteriogram and embolization. Read More

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http://dx.doi.org/10.7759/cureus.7365DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7174856PMC

Acute Kidney Injury Caused by Superior Mesenteric Artery Syndrome.

Case Rep Nephrol 2020 9;2020:8364176. Epub 2020 Apr 9.

Nephrology Unit, Medical Department, National University of Malaysia Medical Centre, Kuala Lumpur, Malaysia.

Background: Superior mesenteric artery (SMA) syndrome is a rare cause of upper gastrointestinal obstruction leading to acute kidney injury (AKI).

Methods: We report a case of 23-year-old army personnel who presented with persistent vomiting leading to severe hypokalaemia, metabolic alkalosis, and acute kidney injury resulting in cardiorespiratory arrest.

Results: After successful resuscitation, he was supported with haemodialysis and aggressive electrolytes correction. Read More

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http://dx.doi.org/10.1155/2020/8364176DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7171609PMC

Antibacterial activity of ethoxzolamide against strains SS1 and 26695.

Gut Pathog 2020 15;12:20. Epub 2020 Apr 15.

1Department of Microbiology, Monash University, Clayton, VIC 3800 Australia.

With the rise of bacterial resistance to conventional antibiotics, re-purposing of Food and Drug Administration (FDA) approved drugs currently used to treat non-bacteria related diseases as new leads for antibacterial drug discovery has become an attractive alternative. Ethoxzolamide (EZA), an FDA-approved diuretic acting as a human carbonic anhydrase inhibitor, is known to kill the gastric pathogenic bacterium in vitro via an, as yet, unknown mechanism. To date, EZA activity and resistance have been investigated for only one strain, P12. Read More

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http://dx.doi.org/10.1186/s13099-020-00358-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7158114PMC

Effects of Helicobacter pylori on the glutathione-related pathway in gastric epithelial cells.

Biochem Biophys Res Commun 2020 Jun 17;526(4):1118-1124. Epub 2020 Apr 17.

Division of Gastroenterology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.

Virulence factors of Helicobacter pylori (H. pylori) are diverse, so various biological responses happen in a host infected with H. pylori. Read More

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http://dx.doi.org/10.1016/j.bbrc.2020.04.019DOI Listing

Successful Hemostasis With Endoscopic Suturing of Recurrent Duodenal Ulcer Bleeding After Failed Initial Endoscopic Therapy and Embolization.

ACG Case Rep J 2020 Feb 20;7(2):e00275. Epub 2020 Feb 20.

Division of Gastroenterology and Hepatology, University of Maryland Medical Center, Baltimore, MD.

Peptic ulcer bleeding is a common condition where endoscopic therapy offers a safe and definitive treatment. However, management of peptic ulcer bleeding can be more complex when there is large volume, recurrent bleeding in a critically ill patient. We present a patient with life-threatening, recurrent duodenal ulcer bleeding who failed both standard endoscopic therapy and transarterial embolization. Read More

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http://dx.doi.org/10.14309/crj.0000000000000275DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7145181PMC
February 2020