33,915 results match your criteria Duodenal Ulcers


How did the ancient bacterium, , cause an epidemic of chronic duodenal ulceration?

JGH Open 2021 Jun 18;5(6):636-642. Epub 2021 May 18.

Faculty of Health and Medical Sciences University of Adelaide Adelaide South Australia Australia.

The association of with chronic duodenal ulceration was a seminal observation in the short history of gastroenterology. However, is now known to be an ancient bacterium, whereas there is persuasive evidence that the epidemic of duodenal ulceration began in the second half of the 19th century and continued into the second half of the 20th century. Possible explanations for the epidemic include genomic changes in the organism and environmental or other influences on the human host. Read More

View Article and Full-Text PDF

The rare entity of cholocystocolonic fistula: a case report.

Pan Afr Med J 2021 15;38:262. Epub 2021 Mar 15.

Second Department of Propedeutic Surgery, Laiko General Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece.

Cholocystocolonic fistulas (CCFs) represent a rare medical entity. Previous inflammatory processes in the abdomen, especially in the gallbladder and surgeries are all related to their appearance. There are not typical findings concerning the clinical image and the therapeutic approach varies between patients. Read More

View Article and Full-Text PDF

Predictors of the need for surgery in upper gastrointestinal bleeding in a resource constrained setting: the Pietermaritzburg experience.

S Afr J Surg 2020 Dec;58(4):199-203

Department of Surgery, University of KwaZulu-Natal, South Africa and Department of Surgery, University of the Witwatersrand, South Africa.

Background: This review from a tertiary centre in South Africa aims to describe the spectrum and outcome of upper gastrointestinal bleeding (UGIB) and identify risk factors for surgical management and death.

Methods: This was a retrospective review of a prospectively entered database of all adults presenting with UGIB between December 2012 and December 2016. Demographics, presenting physiology, risk assessment scores, outcomes of endoscopy endo-therapy and surgery were reviewed. Read More

View Article and Full-Text PDF
December 2020

Epidemiological and clinical features of functional dyspepsia in a region with a high incidence of esophageal cancer in China.

Chin Med J (Engl) 2021 Jun 4;134(12):1422-1430. Epub 2021 Jun 4.

Department of Gastroenterology, Peking University Third Hospital, Beijing 100191, China.

Background: Functional dyspepsia (FD) has rarely been investigated in areas with a high prevalence of esophageal squamous cell carcinoma (ESCC). This study aims to reveal the epidemiological and clinical features of FD and organic dyspepsia (OD) in such a population.

Methods: A middle-aged and elderly population-based study was conducted in a region with a high incidence of ESCC. Read More

View Article and Full-Text PDF

The TNF-A-857*T Polymorphism is Associated with Gastric Adenocarcinoma Risk in a Costa Rican Population.

Am J Med Sci 2021 Jan 31. Epub 2021 Jan 31.

Institute of Health Research (INISA), University of Costa Rica, Costa Rica; Department of Public Nutrition, School of Nutrition, University of Costa Rica, Costa Rica. Electronic address:

Background: Costa Rica is ranked as one of the countries with highest incidence of gastric cancer worldwide. Previous studies in Costa Rican populations have revealed associations between gastric cancer risk and several cytokine polymorphisms that seem to play a role in the regulation of the expression of these proteins. In this study, we assessed associations of the polymorphisms IL-6-174 G/C, IFNGR1-56 C/T, IL-8-251 T/A and TNF-A (-857 C/T, -308 A/G) with gastric pathologies in a high-risk population of Latin America. Read More

View Article and Full-Text PDF
January 2021

Aminofutalosine Deaminase in the Menaquinone Pathway of .

Biochemistry 2021 Jun 2. Epub 2021 Jun 2.

Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York 10461, United States.

is a Gram-negative bacterium that is responsible for gastric and duodenal ulcers. uses the unusual pathway with aminofutalosine (AFL) as an intermediate for menaquinone biosynthesis. Previous reports indicate that hydrolysis of AFL by 5'-methylthioadenosine nucleosidase (MTAN) is the direct path for producing downstream metabolites in the pathway. Read More

View Article and Full-Text PDF

Nanomechanical Hallmarks of Infection in Pediatric Patients.

Int J Mol Sci 2021 May 25;22(11). Epub 2021 May 25.

Department of Medical Microbiology and Nanobiomedical Engineering, Medical University of Bialystok, PL-15222 Bialystok, Poland.

Background: the molecular mechanism of gastric cancer development related to () infection has not been fully understood, and further studies are still needed. Information regarding nanomechanical aspects of pathophysiological events that occur during infection can be crucial in the development of new prevention, treatment, and diagnostic measures against clinical consequences associated with infection, including gastric ulcer, duodenal ulcer, and gastric cancer.

Methods: in this study, we assessed mechanical properties of children's healthy and positive stomach tissues and the mechanical response of human gastric cells exposed to heat-treated cells using atomic force microscopy (AFM NanoWizard 4 BioScience JPK Instruments Bruker). Read More

View Article and Full-Text PDF

Persisting bleeding from the duodenal ulcer in patients with occlusion of the celiac trunk: a case report.

Pol Przegl Chir 2020 Oct;93(2):1-5

Department of Imaging Diagnostics and Interventional Radiology, Pomeranian Medical University in Szczecin, Poland.

Introduction: Endoscopic measures have continued to be the primary procedures in the management of ulcer bleeding. Nevertheless, in cases of failed endoscopic hemostasis and re-bleedings, endovascular techniques have gradually gained increased acceptance as an alternative to surgery, allowing to avoid surgical intervention in some cases. <br/> Case report: A case of a 42-year-old patient presenting to the authors' institution with massive bleeding from the duodenal ulcer, sprang from a pathologically enlarged gastroduodenal artery is reported. Read More

View Article and Full-Text PDF
October 2020

Intraluminal Endovascular Coil Migration: A Rare Complication Post-Embolization of the Gastroduodenal Artery for a Previously Bleeding Duodenal Ulcer.

Cureus 2021 Apr 21;13(4):e14615. Epub 2021 Apr 21.

Gastroenterology, University of Nevada Las Vegas School of Medicine, Las Vegas, USA.

Transarterial angiographic embolization is a highly effective, safe treatment for non-variceal upper gastrointestinal bleeding refractory to endoscopic intervention. However, intraluminal coil migration is a possible complication. Coil migration, while usually a self-limiting process, can lead to significant rebleeding. Read More

View Article and Full-Text PDF

Primary duodenal tuberculosis complicated with perforation: A review of literature and case report.

Ann Med Surg (Lond) 2021 Jun 12;66:102392. Epub 2021 May 12.

Department of Digestive Surgery 'A', La Rabta Hospital University, Faculty of Medicine of Tunis, Tunisia.

Tuberculous (TB) disease remains an endemic pathology in Tunisia. the ileocecal region is the predominant site of involvement while gastroduodenal tuberculosis is very rare, this form is often presenting as one of the complications, mainly upper gastrointestinal stenosis or exceptionally as a perforation. We describe a case of female patient aged 33 years-old presented with a 2-day history of acute abdominal pain, with a tenderness of the right hypochondrium and the epigastrium, ultrasound of the abdomen revealed gallbladder distension with a wall thickening. Read More

View Article and Full-Text PDF

Preventive covered stent placement at the gastroduodenal artery stump in angiogram-negative sentinel hemorrhage after pancreaticoduodenectomy.

Abdom Radiol (NY) 2021 May 26. Epub 2021 May 26.

Department of Radiology, Taipei Veterans General Hospital, Taipei, 112, Taiwan.

Purpose: To evaluate the clinical outcomes of preventive covered stent placement at the gastroduodenal artery stump in patients with angiogram-negative sentinel hemorrhage after pancreaticoduodenectomy.

Methods: Between July 2006 and September 2018, patients undergoing computed tomography angiography or diagnostic angiography for sentinel hemorrhage after pancreaticoduodenectomy were retrospectively reviewed. Patients having angiogram-negative angiography and undergoing preventive covered stent placement or conservative treatment were included. Read More

View Article and Full-Text PDF

Management of Biliopancreatic Limb Bleeding after Roux-en-Y Gastric Bypass: A Case Report.

Clin Endosc 2021 May 25. Epub 2021 May 25.

Department of Gastroenterology, School of Medicine, Pontificia Universidad Católica de Chile.

The Roux-en-Y gastric bypass is one of the most extensive surgical treatments for obesity. The treatment of upper gastrointestinal bleeding after Roux-en-Y gastric bypass is complex due to the difficulty of accessing the excluded gastric antrum and duodenal bulb. There is no consensus regarding the management of this complication. Read More

View Article and Full-Text PDF

Transient Trabecular Formation in the Bladder and Delayed Free Air due to Traumatic Intraperitoneal Bladder Rupture.

Cureus 2021 Apr 16;13(4):e14520. Epub 2021 Apr 16.

Surgery, Shizuoka Hospital, Juntendo University, Izunokuni, JPN.

An H-section steel bar that had been set against the wall fell and hit the abdomen and then both legs of a 33-year-old Chinese man. As his vital signs were stable and his chief complaint was leg pain, he was transferred to a local medical facility. After the confirmation of gross hematuria by an indwelling a bladder catheter there, he was transported to our hospital. Read More

View Article and Full-Text PDF

A pilot study to evaluate the effectiveness and safety of urgent endoscopy for gastroduodenal perforation.

Surg Endosc 2021 May 19. Epub 2021 May 19.

Department of Gastroenterology, Hiroshima City Asa Citizens Hospital, Hiroshima, Japan.

Background: Gastroduodenal perforation is potentially life threatening and requires early diagnosis and treatment. Urgent endoscopy facilitates detecting bleeding sites and achieving hemostasis. However, there is no consensus on urgent endoscopy for gastroduodenal perforation in Japan. Read More

View Article and Full-Text PDF

The clinical and endoscopic aspects of peptic ulcers secondary to the use of nonsteroidal anti-inflammatory drugs of various origins.

Pan Afr Med J 2021 15;38:170. Epub 2021 Feb 15.

Anesthesia-Reanimation Service, Hospital of Sikasso, Sikasso, Mali.

Introduction: currently, the non-steroid anti-inflammatory drugs constitute a veritable object of auto medication throughout the world. The goal of this study was to evaluate the endoscopic and clinical aspects of gastro-duodenal ulcer secondary to taking of non-steroid anti-inflammatory of various sources.

Methods: this was a cross-sectional study which was conducted between July 2016 and December 2017. Read More

View Article and Full-Text PDF

New isolate from Salvinia molesta with antioxidant and urease inhibitory activity.

Drug Dev Res 2021 May 13. Epub 2021 May 13.

Drug Design Development Research Group, Department of Chemistry, Universiti Malaya, Kuala Lumpur, Malaysia.

Urease plays a significant role in the pathogenesis of urolithiasis pyelonephritis, urinary catheter encrustation, hepatic coma, hepatic encephalopathy, and peptic acid duodenal ulcers. Salvinia molesta was explored to identify new bioactive compounds with particular emphasis on urease inhibitors. The aqueous methanol extract was fractionated using solvents of increasing polarity. Read More

View Article and Full-Text PDF

Prevalence of tumor necrosis factor alpha inducing protein () gene of and its association with upper gastrointestinal diseases in India.

3 Biotech 2021 May 30;11(5):246. Epub 2021 Apr 30.

Centre for Medical Biotechnology, Amity Institute of Biotechnology, Amity University, Noida, UP India.

() is known to cause several gastroduodenal diseases including chronic Gastritis, Peptic Ulcer disease and Gastric Cancer. Virulent genes of like , are known to be responsible for the disease pathogenesis. However, these virulence genes are not always found to be associated with disease outcome in all populations around the world. Read More

View Article and Full-Text PDF

Protective effect and mechanisms of action of Mongolian medicine Sulongga-4 on pyloric ligation-induced gastroduodenal ulcer in rats.

World J Gastroenterol 2021 Apr;27(16):1770-1784

School of Mongolian Medicine, Inner Mongolia University for Nationalities, Tongliao 028000, Inner Mongolia Autonomous Region, China.

Background: Sulongga-4 (SL-4) is a herbal formula used in traditional Mongolian medical clinics for the treatment of peptic ulcers and gastroenteritis, even though its pharmacological mechanism has not been well characterized.

Aim: To evaluate the protective effect and identify the mechanisms of action of SL-4 on gastroduodenal ulcer induced by pyloric ligation (PL) in rats.

Methods: PL was performed to induce gastric and duodenal ulcers in rats, which were then treated with oral SL-4 (1. Read More

View Article and Full-Text PDF

[Endoscopic Hemostasis and Its Related Factors of Duodenal Hemorrhage].

Zhongguo Yi Xue Ke Xue Yuan Xue Bao 2021 Apr;43(2):222-229

Department of Gastroenterology,PUMC Hospital,CAMS and PUMC,Beijing 100730,China.

Objective To analyze clinical characteristics and short-term efficacy of endoscopic hemostasis in acute duodenal hemorrhage. Methods A retrospective study was conducted for the patients who received endoscopy in the PUMC Hospital due to upper gastrointestinal bleeding and were confirmed to be on account of duodenal lesions for bleeding from January 2011 to December 2018.Clinical information of patients was collected,including demographics,comorbidities,and medication use. Read More

View Article and Full-Text PDF

A rare case of refractory and severe duodenal ulcers associated with olmesartan.

Gastrointest Endosc 2021 May 6. Epub 2021 May 6.

Department of Gastroenterology and Hepatology, Nara Medical University.

View Article and Full-Text PDF

Composite detection rate as an upper gastrointestinal endoscopy quality measure correlating with detection of neoplasia.

J Gastroenterol 2021 May 2. Epub 2021 May 2.

Chair and department of Gastroenterology and Hepatology, School of Medicine in Katowice, Medical University of Silesia, Medyków 14 Street, 40-752, Katowice, Poland.

Background: Esophagogastroduodenoscopy (EGD) is commonly used diagnostic method with no widely accepted quality measure. We assessed quality indicator-composite detection rate (CDR)-consisting of detection of at least one of the following: cervical inlet patch, gastric polyp and post-ulcer duodenal bulb deformation. The aim of the study was to validate CDR according to detection rate of upper gastrointestinal neoplasms (UGN). Read More

View Article and Full-Text PDF

Histamine receptor 2 blockade selectively impacts B and T cells in healthy subjects.

Sci Rep 2021 Apr 30;11(1):9405. Epub 2021 Apr 30.

Dalhousie Human Immunology and Inflammation Group, Department of Microbiology and Immunology, Dalhousie University, Sir Charles Tupper Medical Building, Room 7-C2, 5850 College Street, PO Box 15000, Halifax, NS, B3H 4R2, Canada.

Histamine receptor 2 (H2R) blockade is commonly used in patients with gastric, duodenal ulcers or gastroesophageal reflux disease. Beyond the gastrointestinal tract, H2R is expressed by multiple immune cells, yet little is known about the immunomodulatory effects of such treatment. Clinical reports have associated H2R blockade with leukopenia, neutropenia, and myelosuppression, and has been shown to provide clinical benefit in certain cancer settings. Read More

View Article and Full-Text PDF

Endoscopic assessment of morphological and histopathological upper gastrointestinal changes after endoscopic sleeve gastroplasty.

Surg Obes Relat Dis 2021 Jul 2;17(7):1294-1301. Epub 2021 Apr 2.

IHU-Strasbourg, Institute of Image-Guided Surgery, Strasbourg, France; IRCAD, Research Institute against Digestive Cancer, Strasbourg, France; Department of Digestive and Endocrine Surgery, Nouvel Hôpital Civil, Strasbourg University Hospital, Strasbourg, France.

Background: Endoscopic sleeve gastroplasty (ESG) is a promising bariatric endoluminal procedure. Restriction and shortening of the stomach are obtained by means of non-resorbable full-thickness sutures, thus inducing the formation of several endoluminal pouches in which food can stagnate. The effect of ESG on the upper gastrointestinal tract has never been investigated. Read More

View Article and Full-Text PDF

Presence of and DNA in Free-Range Wild Boars.

Animals (Basel) 2021 Apr 28;11(5). Epub 2021 Apr 28.

Institute of Biomedical Sciences Abel Salazar (ICBAS), University of Porto, 4050-313 Porto, Portugal.

() is a Gram-negative bacterium that infects half of the human population worldwide, causing gastric disorders, such as chronic gastritis, gastric or duodenal ulcers, and gastric malignancies. is mainly associated with pigs, but can also colonize the stomach of humans, resulting in gastric pathologies. In pigs, can induce gastritis and seems to play a role in gastric ulcer disease, seriously affecting animal production and welfare. Read More

View Article and Full-Text PDF

Clinical Characteristics of Primary Repair for Perforated Peptic Ulcer: 10-Year Experience in a Single Center.

J Clin Med 2021 Apr 20;10(8). Epub 2021 Apr 20.

Department of Surgery, Inha University Hospital, College of Medicine, Jung-gu, Inchon 22332, Korea.

Background: Perforated peptic ulcer (PPU) is a disease whose incidence is decreasing. However, PPU still requires emergency surgery. The aim of this study was to review the clinical characteristics of patients who received primary repair for PPU and identify the predisposing factors associated with severe complications. Read More

View Article and Full-Text PDF

Indications and Findings of Upper Endoscopies in Males and Females, Are They the Same or Different?

J Clin Med 2021 Apr 11;10(8). Epub 2021 Apr 11.

Soroka University Medical Center, Faculty of Health Sciences, The Institute of Gastroenterology and Hepatology, Ben-Gurion University of the Negev, Beer-Sheva 84101, Israel.

Sex and gender can affect the prevalence and prognosis of diseases. Our aim was to assess similarities and differences for males and females who underwent an upper endoscopy, with regards to indications and results. We reviewed all upper endoscopy reports from 2012 to 2016. Read More

View Article and Full-Text PDF

Helicobacter pylori and colorectal neoplasms: a concise review.

Arq Gastroenterol 2021 Jan-Mar;58(1):114-119

Faculdade de Ciências Médicas de Minas Gerais, Belo Horizonte, MG, Brasil.

Helicobacter pylori is the main etiological agent of all malignant tumors caused by an infectious disease. It is a major, at times dominant, factor in the pathogenesis of a large spectrum of diseases such as acute and chronic gastritis, gastric and duodenal ulcers, gastric carcinoma, and lymphoma. Epidemiological and experimental studies suggest that H. Read More

View Article and Full-Text PDF

Diagnostic utility of abdominal ultrasound for detecting non-perforated gastroduodenal ulcers in dogs.

Vet Rec 2021 Apr 26:e199. Epub 2021 Apr 26.

Willows Referral Centre, Solihull, UK.

Background: Abdominal ultrasound is frequently used to detect non-perforated gastroduodenal ulcers in dogs. Studies assessing the diagnostic utility of abdominal ultrasound for the detection of non-perforated gastroduodenal ulcers have yielded mixed results. No studies to date have investigated the effects of patient bodyweight, breed, sex, age, ulcer aetiology (neoplastic or inflammatory) or location on the diagnostic accuracy of abdominal ultrasound. Read More

View Article and Full-Text PDF