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Z Gastroenterol 2021 Jun 15;59(6):556-559. Epub 2021 Jun 15.

Innere Medizin, Krankenhaus St. Marienwörth, Bad Kreuznach, Germany.

Dumping syndromes are a common side effect after partial or total gastric resection. The symptoms may be diverse, with vasomotoric reactions, collapse tendencies and digestive disorders (early dumping) as well as blood sugar derailment as a result of too fast absorption of glucose (late dumping).Entrenched therapy concepts, including personalized nutritional concepts and the use of medication as octreotide or diazoxide, will not always lead to the desired results. Read More

World J Gastrointest Surg 2021 May;13(5):461-475

Department of Gastroenterological Surgery, Nagoya University Graduate School of Medicine, Nagoya 466-8550, Japan.

Background: The effects of various gastrectomy procedures on the patient's quality of life (QOL) are not well understood. Thus, this nationwide multi-institutional cross-sectional study using the Postgastrectomy Syndrome Assessment Scale-45 (PGSAS-45), a well-established questionnaire designed to clarify the severity and characteristics of the postgastrectomy syndrome, was conducted.

Aim: To compare the effects of six main gastrectomy procedures on the postoperative QOL. Read More

Cureus 2021 May 6;13(5):e14869. Epub 2021 May 6.

Gastroenterology and Hepatology, Istanbul Medeniyet University Göztepe Research and Training Hospital, Istanbul, TUR.

Surgeries for obesity can lead to complications. Dumping syndrome is one such complication caused by the quick passage of hyperosmolar chyme from the stomach to the duodenum. Mild cases can be cured with dietary modification and medical treatment. Read More

J Laparoendosc Adv Surg Tech A 2021 Jun 7. Epub 2021 Jun 7.

Department of Surgery and Hospital de Gastroenterología "Dr. Carlos Bonorino Udaondo," Ciudad Autónoma de Buenos Aires, Argentina.

Patients with hereditary diffuse gastric cancer (HDGC) and germline mutations in the E-cadherin gene, , have a very high cumulative lifetime risk of developing diffuse gastric cancer. In these patients, it is formally recommended to perform a prophylactic total gastrectomy (PTG). We analyzed the course of patients with HDGC who have undergone PTG in our institution. Read More

Langenbecks Arch Surg 2021 May 25. Epub 2021 May 25.

Department of Visceral and Transplant Surgery, University Hospital Zurich, Zurich, Switzerland.

Background: Surgery is the cornerstone of esophageal cancer treatment but remains burdened with significant postoperative changes of gastrointestinal function and quality of life.

Purpose: The aim of this narrative review is to assess and summarize the current knowledge on postoperative functional syndromes and quality of life after esophagectomy for cancer, and to provide orientation for the reader in the challenging field of functional aftercare.

Conclusions: Post-esophagectomy syndromes include various conditions such as dysphagia, reflux, delayed gastric emptying, dumping syndrome, weight loss, and chronic diarrhea. Read More

Medicine (Baltimore) 2021 May;100(21):e26086

Department of Endocrinology, Nanjing First Hospital, Nanjing Medical University, Jiangsu, China.

Rationale: Dumping syndrome is a frequent and potentially severe complication after gastric surgery. Beinaglutide, a recombinant human glucagon-like peptide-1 (GLP-1) which shares 100% homology with human GLP-1(7-36), has never been reported in the treatment of dumping syndrome before.

Patient Concerns: The patient had undergone distal gastrectomy for gastric signet ring cell carcinoma 16 months ago. Read More

Neurogastroenterol Motil 2021 Jun 17;33(6):e14172. Epub 2021 May 17.

Department of Paediatric Gastroenterology, Hepatology and Nutrition, KidZ Health Castle UZ Brussel, Brussels, Belgium.

C-gastric emptying breath tests ( C-GEBT) are validated, reliable, and non-invasive tools for measurement of gastric emptying (GE) velocity of solids and liquids without radiation exposure or risk of toxicity. They are recommended and routinely used for clinical purposes in adult as well as pediatric patients and can be readily performed onsite or even at the patient's home. However, the underlying methodology is rather complex and test results can be influenced by dietary factors, physical activity, concurrent diseases, and medication. Read More

Obes Surg 2021 Apr 21. Epub 2021 Apr 21.

Multidisciplinary Department of Bariatric and Metabolic Surgery, Centro Hospitalar Universitário de Lisboa Central, Lisbon, Portugal.

Introduction: One anastomosis gastric bypass (OAGB) is an effective bariatric procedure. However, nutritional deficiencies or dumping syndrome (DS) may occur. The aim of this study was to assess adherence to nutritional recommendations and development of DS in a 3-year OAGB patient follow-up. Read More

Endocrinol Diabetes Metab Case Rep 2021 Mar 20;2021. Epub 2021 Mar 20.

Endocrinology and Nutrition, Hospital Universitari Germans Trias I Pujol, Badalona, Spain.

Summary: Hypoglycemia is an uncommon clinical problem in non-diabetic patients or patients not being treated for diabetes mellitus. It is a rare, but well-established complication of bariatric surgery and, in some cases, it can be the only symptom of another medical problem. A 50-year-old woman with a history of partially recovered hypopituitarism after transsphenoidal surgery for a non-functioning pituitary macroadenoma complained about symptomatic hypoglycemia after sleeve gastrectomy surgery. Read More

Cir Pediatr 2021 Apr 1;34(2):67-73. Epub 2021 Apr 1.

Pediatric Surgery Department. Niño Jesús Pediatric University Hospital. Madrid (Spain).

Objective: To study gastroesophageal reflux (GER) in children undergoing gastrostomy in a single pediatric institution.

Material And Methods: A retrospective study of patients undergoing gastrostomy from 2000 to 2017 was carried out. Demographic data, clinical data, progression, and complications were recorded. Read More

Obes Surg 2021 May 3;31(5):2353-2355. Epub 2021 Mar 3.

Department of Surgery, AZ Sint-Jan Hospital, Ruddershove 10, B-8000, Bruges, Belgium.

Introduction: Postoperative dumping syndrome (DS) is a common complication after Roux-en-y gastric bypass (RYGB) for morbid obesity. DS is mostly treated conservatively through dietary or pharmacologic measures. In case of non-responding to or contraindication for conservative treatment, surgical intervention may be considered. Read More

Obes Surg 2021 06 23;31(6):2619-2631. Epub 2021 Feb 23.

Upper Gastrointestinal Surgery, St George Private Hospital, Kogarah, Sydney, NSW, 2217, Australia.

Purpose: Bariatric surgery is an effective treatment for obesity with new procedures emerging. However, despite comparable weight loss and improvements in metabolic outcomes, research on nutritional and gastrointestinal symptoms remains limited. Here we compare clinical data on weight, nutritional disorders and gastrointestinal symptoms of patients before and following one anastomosis gastric bypass (OAGB) and Roux-en-Y gastric Bypass (RYGB). Read More

Afr J Paediatr Surg 2021 Jan-Mar;18(1):47-52

Department of Pediatrics, The Scientific Center of Pediatrics and Pediatric Surgery, Almaty, Republic of Kazakhstan.

Introduction: Gastroesophageal reflux disease is one of the most common diseases among a wide range of chronic inflammatory diseases of the gastrointestinal tract in children of all ages, significantly impairing the quality of life of the child and posing a serious threat to the health of the patient.

Materials And Methods: From 2008 to 2019, 134 patients aging from 6 months to 12 years were hospitalized at the Scientific Center for Pediatrics and Pediatric Surgery, including 69 (51%) infants. Of them, 51 (38%) were the patients with persistent manifestations of regurgitation, despite an outpatient course of conservative therapy; 29 (22%) patients with recurrent reflux-associated pneumonia; also, 35 (26%) children with gastroesophageal reflux in the structure of the main pathology of the central nervous system, as well as 19 (14%) patients after surgery of the anastomosis of the esophagus with its atresia. Read More

J Med Case Rep 2021 Feb 16;15(1):75. Epub 2021 Feb 16.

Department of Pediatrics, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Kumamoto City, Kumamoto Prefecture, 860-8556, Japan.

Background: Glycogen storage disease (GSD) type Ia is a glycogenesis disorder with long-term complications such as hepatomegaly and renal dysfunction and is caused by congenital loss of glucose-6-phosphatase (G6Pase) expression. G6Pase is essential for the final step of gluconeogenesis and glycogenolysis, and its deficiency causes clinical hypoglycemia in the fasting state during infancy. Contrastingly, patients also show blood glucose trends and glucose intolerance similar to those in type II diabetes. Read More

Pediatr Int 2021 Feb 9. Epub 2021 Feb 9.

Department of Pediatric Surgery, Kurume University School of Medicine, Fukuoka, Japan.

Background: Neurological impairment (NI) is responsible for most conditions that require a permanent gastrostomy tube. The present study assessed the occurrence of short- and long-term complications after video-assisted gastrostomy (VAG) in patients with NI.

Methods: The incidence rates of short- (<6 months) and long-term (over two years) complications of VAG were analyzed in a retrospective study. Read More

Nat Rev Endocrinol 2021 05;17(5):317

Department of Endocrinology, Ghent University Hospital, Ghent, Belgium.

Nat Rev Endocrinol 2021 05;17(5):317-318

Translational Research Center for Gastrointestinal Disorders, Department of Chronic Diseases, Metabolism and Ageing, Catholic University of Leuven, Leuven, Belgium.

Clin Transl Gastroenterol 2020 12;11(12):e00229

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.

Introduction: Bile acids, such as chenodeoxycholic acid, play an important role in digestion but are also involved in intestinal motility, fluid homeostasis, and humoral activity. Colonic delivery of sodium chenodeoxycholate (CDC) has demonstrated clinical efficacy in treating irritable bowel syndrome with constipation but was associated with a high frequency of abdominal pain. We hypothesized that these adverse effects were triggered by local super-physiological CDC levels caused by an unfavorable pharmacokinetic profile of the delayed release formulation. Read More

J Endocr Soc 2021 Mar 2;5(3):bvaa197. Epub 2021 Jan 2.

Division of Pediatric Endocrinology, Department of Pediatrics, University of California, San Francisco, San Francisco, CA, United States.

Gastrostomy tubes (G-tubes) and Nissen fundoplication are common surgical interventions for feeding difficulties and gastroesophageal reflux disease in children. A potential yet often missed, complication of these procedures is dumping syndrome. We present 3 pediatric patients with postprandial hypoglycemia due to late dumping syndrome after gastric surgeries. Read More

Crit Rev Food Sci Nutr 2021 Jan 18:1-14. Epub 2021 Jan 18.

Department of Clinical Medicine and Surgery, University of Naples Federico II School of Medicine and Surgery, Naples, Italy.

Hypoglycemia is a pathological condition characterized by a low plasma glucose concentration associated with typical autonomic and/or neuroglycopenic symptoms, and resolution of these symptoms with carbohydrate consumption. Hypoglycemia is quite common in clinical practice, particularly in insulin-treated patients with diabetes and in other inherited or acquired conditions involving the regulation of glucose metabolism. Beyond symptoms that might strongly affect the quality of life, hypoglycemia can lead to short- and long-term detrimental consequences for health. Read More

J Visc Surg 2021 02 9;158(1):51-61. Epub 2021 Jan 9.

French and Francophone Society of Obesity Surgery and Metabolic Disorders (SO.FF.CO.MM), France.

Nutritional care after bariatric surgery is an issue of major importance, especially insofar as risk of deficiency has been extensively described in the literature. Subsequent to the deliberations carried out by a multidisciplinary working group, we are proposing a series of recommendations elaborated using the Delphi-HAS (official French health authority) method, which facilitates the drawing up of best practice and consensus recommendations based on the data of the literature and on expert opinion. The recommendations in this paper pertain to dietary management and physical activity, multivitamin and trace element supplementation and the prevention and treatment of specific deficiencies in vitamins B1, B9, B12, D and calcium, iron, zinc, vitamins A, E and K, dumping syndrome and reactive hypoglycemia. Read More

Regen Ther 2020 Dec 4;15:129-137. Epub 2020 Aug 4.

Department of Surgery, Nagasaki University Graduate School of Biomedical Sciences, Japan.

The main surgical strategy for gastrointestinal tract malignancy is resection, which consists of not only resection of the involved organs but also simultaneous resection of the surrounding or adjacent mesenteries that contain lymph vessels and nodes. After resection of the diseased organs, the defect of the gastrointestinal conduit is replaced with organs located downstream, such as the stomach and jejunum. However, esophageal and gastric reconstruction using these natural substitutes is associated with a diminished quality of life due to the loss of the reserve function, damage to the antireflux barrier, and dumping syndrome. Read More

Surg Endosc 2021 Jan 4. Epub 2021 Jan 4.

Bariatric Endoscopy Service, Department of Gastroenterology and Liver Disease, Tel Aviv Sourasky Medical Center, affiliated with the Sackler School of Medicine, Tel Aviv University, Weizman 6 st., 6423906, Tel Aviv, Israel.

Background: Dumping syndrome (DS) is a common complication of bariatric surgery. Treatments include dietary and behavioral changes, as well as pharmacotherapy and revision surgery. All can be costly or hard to adhere to. Read More

Pediatr Surg Int 2021 Feb 3;37(2):183-189. Epub 2021 Jan 3.

Department of Pediatric Surgery, Shizuoka Children's Hospital, 860 Urushiyama, Aoi-ku, Shizuoka, 420-8660, Japan.

Purpose: In postoperative cases of fundoplication, the gastric emptying ability is promoted and sometimes exhibits dumping syndrome. Dumping syndrome often goes unrecognized in children. Furthermore, the risk factors for postoperative dumping syndrome are unknown. Read More

Endocrinol Diabetes Nutr 2021 Jun-Jul;68(6):428-438. Epub 2020 Dec 31.

Servicio de Endocrinología y Nutrición, Hospital Universitario Puerta de Hierro Majadahonda, Madrid, España.

Gastric cancer is the third leading cause of cancer mortality and is frequently associated with nutritional disorders, the detection and proper management of which can contribute to improving quality of life and survival. Being aware of the consequences and of the different treatments for this neoplasm allows us to offer an adequate nutritional approach. In surgical candidates, integration into ERAS-type programs (Enhanced Recovery after Surgery) is increasingly frequent, and includes a pre-surgical nutritional approach and the initiation of early oral tolerance. Read More

Zhonghua Wei Chang Wai Ke Za Zhi 2020 Nov;23(11):1088-1096

Department of Gastrointestinal Surgery, the First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, China.

It is yet to be clarified whether pylorus-preserving gastrectomy (PPG) for early gastric cancer will bring the risk of radical tumor resection, whether it will increase the incidence of postoperative complications, and how much is the benefit of the quality of life for patients after surgery, these issues are not clear. This meta-analysis aims to evaluate the efficacy and safety of pylorus-preserving gastrectomy (PPG) for early middle gastric cancer. The Chinese and English literatures about PPG and distal gastrectomy (DG) for early gastric cancer were searched from PubMed, Embase, The Cochrane Library, Web of Science, CNKI net and Wanfang database. Read More

Neuro Endocrinol Lett 2020 Sep;41(2):55-59

Clinic of Surgery and Transplant Center, Jessenius Faculty of Medicine, Comenius University in Bratislava, University Hospital, Martin, Slovakia.

Dumping syndrome is a common post-operative complication following gastric surgery. Clinically, severe dumping can be a serious medical condition with a negative impact on the patient's life. In our case report, we present a case of refractory dumping syndrome which developed after laparoscopic subtotal gastrectomy with gastrojejunoanastomosis due to massive gastroptosis with stomach evacuation problems. Read More

Obes Surg 2021 Jan 9;31(1):467-468. Epub 2020 Nov 9.

Department of Gastroenterology, Clemenceau Medical Center, Beirut, Lebanon.

Introduction: Post-bariatric surgery hypoglycemia is usually seen in patients with a history of gastric bypass surgery [1], and few experience severe symptoms [2]. The pathophysiology of post-gastric bypass surgery hypoglycemia is not well understood, and many theories have been proposed: excessive GLP-1, nesidioblastosis, and increased glucose effectiveness [3]. Thus, the etiology of this condition is complex. Read More

J Gastrointest Surg 2020 Nov 4. Epub 2020 Nov 4.

Department of Thoracic Surgery, Virginia Mason Medical Center, 1100 Ninth Ave, Seattle, WA, 98101, USA.

Background: High-quality documentation of dumping symptoms after esophagectomy is currently limited. The aim of the study was to describe the incidence of symptoms associated with dumping syndrome and their relationship with health-related quality of life after esophagectomy.

Methods: The study cohort was identified from prospective IRB-approved databases from two high-volume esophagectomy centers. Read More

Zhonghua Wei Chang Wai Ke Za Zhi 2020 Oct;23(10):935-938

Department of Gastrointestinal Surgery, the First Affiliated Hospital, Dalian Medical University, Dalian, Liaoning 116011, China.

Function-preserving gastrectomy, especially pylorus-preserving gastrectomy (PPG), can improve the quality of life and has been widely recognized. With the development of surgical techniques and equipment, nerve preservation has become a new requirement in the era of "precision medicine", but the preservation of celiac branch of the vagal nerve remains controversial in gastric cancer surgery. Current researches have shown that the preservation of celiac branch of the vagal nerve is safe and feasible in patients with early gastric cancer. Read More