Search Our Scientific Publications & Authors

Ocul Immunol Inflamm 2019 Feb 22:1-6. Epub 2019 Feb 22.

c Department of Ophthalmology and Visual Science, Seoul St. Mary's Hospital, Catholic Institute for Visual Science, College of Medicine , The Catholic University of Korea , Seoul , Republic of Korea.

Purpose: To compare meibomian gland (MG) imaging findings and lipid layer thickness (LLT) between patients with primary Sjögren syndrome (SS) dry eyes (DE) and non-SS DE.

Methods: A total of 60 patients-30 with SS DE and 30 with non-SS DE were evaluated. Infrared image findings of MGs and LLT were assessed using the LipiView II interferometer. Read More

J Immunol Res 2019 13;2019:7935451. Epub 2019 Jan 13.

Ocular Surface Diseases and Dry Eye Clinic, The Wilmer Eye Institute, Johns Hopkins University, Baltimore, Maryland, USA.

Background: Diagnostic criteria for Sjögren's syndrome (SS) are continually being updated in pursuit of more precise and earlier diagnosis to prevent its complications. Owing to the high rate of false negative traditional serological markers, the need for better serological testing remains.

Objective: To investigate the clinical significance of three recently discovered novel autoantibodies, anti-salivary gland protein 1 (SP1), anti-carbonic anhydrase 6 (CA6), and anti-parotid secretory protein (PSP), in a cohort of dry eye patients with suspected underlying inflammatory/autoimmune disease. Read More

Korean J Ophthalmol 2019 Feb;33(1):26-35

Department of Ophthalmology, Soonchunhyang University Bucheon Hospital, Soonchunhyang University College of Medicine, Bucheon, Korea.

Purpose: To investigate the associations between blood heavy metal concentrations and dry eye disease using a Korean population-based survey.

Methods: This study included 23,376 participants >40 years of age who participated in the Korean National Health and Nutrition Examination Survey from 2010 to 2012. Blood concentrations of lead, cadmium, and mercury were measured in all participants. Read More

J Cell Biochem 2019 Feb 3. Epub 2019 Feb 3.

Cellular and Molecular Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran.

Family with sequence similarity 83 member H (FAM83H) protein-coding geneplay an essential role in the structural organization, calcification of developing enamel, and keratin cytoskeleton disassembly by recruiting Casein kinase 1 alpha (CSNK1A1) to keratin filaments. In this study, we have applied CRISPR Cas9 nickase (D10A) to knockout (KO) the Fam83h gene in NMRI outbred mice. We generated homozygous Fam83h KO mice ( Fam83h ) through a premature termination codon, which was validated by Sanger sequencing in F0 generation. Read More

Hong Kong Med J 2019 Feb 31;25(1):38-47. Epub 2019 Jan 31.

Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Shatin, Hong Kong.

Dry eye disease is one of the most common ophthalmic complaints; it results from the activity of various pathways and is considered a multifactorial disease. An important factor that contributes to the onset of dry eye disease is meibomian gland dysfunction. Meibomian gland dysfunction causes a disruption in the tear film lipid layer which affects the rate of tear evaporation. Read More

Langmuir 2019 Feb 2. Epub 2019 Feb 2.

Dry eye syndrome (DES) is a prevalent disease in which the tear film homeostasis is compromised. One of the main causes of DES is thought to be an alteration in the composition of the outermost layer of the tear film, the tear film lipid layer (TFLL), resulting in increased evaporation of water from the tear film and subsequent drying of the ocular surface. Recent studies have suggested that the specific TFLL-lipids; O-acyl-ω-hydroxy-fatty acids (OAHFAs) and diesters (DiEs) may play a role in development of DES. Read More

J Occup Health 2019 Jan;61(1):19-35

Department of Occupational and Environmental Health, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.

Objectives: 2-Ethyl-1-hexanol (2EH), a fragrance ingredient and a raw material for the production of plasticizer di(2-ethylhexyl) phthalate, is responsible for sick building syndrome (SBS). This review aims to clarify the 2EH characteristics as an indoor air pollutant such as indoor air concentration, emission mechanism, toxicity, and clinical effects.

Methods: Scientific publications in English that has been made available on PubMed as of June 2018 and ad hoc publications in regional languages were reviewed. Read More

BMC Ophthalmol 2019 Jan 28;19(1):35. Epub 2019 Jan 28.

Department of Neural and Behavioral Science, The Pennsylvania State University College of Medicine, MC H109, 500 University Drive, Hershey, PA, 17033-0850, USA.

Background: Dry eye disease (DED) is a prevalent complication of diabetes and presents as reduced tear production and/or increased corneal surface sensitivity often with secondary ocular surface changes. This study examined the safety and efficacy of a proprietary new eye drop formulation for topical treatment of DED.

Methods: Type 1 diabetes (T1D) was established in male Sprague-Dawley rats to study the efficacy and safety of the investigational compound that contained 20 μg/ml of naltrexone (NTX). Read More

J Fr Ophtalmol 2019 Feb 23;42(2):127-132. Epub 2019 Jan 23.

Faculté de médecine et des sciences biomédicales, université de Yaoundé 1, Yaoundé, Cameroun.

Meibomian gland dysfunction is the leading cause of evaporative-type dry eye syndrome. Our goal was to determine the epidemiological and clinical features of meibomian gland dysfunction as well as its impact on the ocular surface in elderly black patients in Cameroon.

Patients And Methods: We performed a cross-sectional analysis from January 2 through May 31, 2017 in the ophthalmology department of Laquintinie Hospital in Douala, including blacks aged 50 years and older. Read More

Cornea 2019 Jan 22. Epub 2019 Jan 22.

Department of Health Services, Policy, and Practice, Center for Evidence Synthesis in Health, Brown University School of Public Health, Providence, RI.

Purpose: Sjögren's syndrome (SS) is a common autoimmune disease affecting about four million Americans. Although approximately 1 in 10 patients with clinically-significant aqueous deficient dry eye has underlying SS, widespread underappreciation of SS leads to significant underdiagnosis, delays in diagnosis, and consequent morbidity and mortality. The purpose of this article is to illustrate that in addition to dry eye, SS can cause serious, vision-threatening extraglandular ocular manifestations. Read More

Sci Total Environ 2019 Mar 11;657:1121-1126. Epub 2018 Dec 11.

Section of Rheumatology, Department of Internal Medicine, Changhua Christian Hospital, Changhua, Taiwan. Electronic address:

Previously, we showed that farm soil levels of chromium were strongly correlated with people's serum chromium levels and an increase (3.6 fold) in both the incidence and prevalence of sicca syndrome in areas where farm soil chromium was high. Because Sjogren's syndrome (SS) is the major disease causing a dry mouth and dry eyes, we aimed in the study to investigate whether these areas with high soil chromium have a high SS prevalence. Read More

Zhongguo Zhen Jiu 2019 Jan;39(1):87-90

College of Acupuncture-Moxibustion and Tuina, Gansu University of CM, Lanzhou 730000, China.

The rules of acupoint selection of acupuncture for dry eye in recent 10 years were summarized to provide reference for clinical treatment. The clinical researches regarding acupuncture for dry eye published from May 5, 2007 to December 1, 2017 were searched in CNKI, WANFANG and VIP database. The acupoint and meridian used and application frequency were analyzed to summarize the rules of acupoint selection. Read More

Zhongguo Zhen Jiu 2018 Nov;38(11):1177-82

Department of Acupuncture and Moxibustion, Guanganmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China; Beijing University of CM.

Objective: To evaluate the effects of walnut-shell moxibusiton on dry eye symptoms.

Methods: A total of 67 patients with dry eye symptoms were randomized into a walnut moxibustion group and a sodium hyaluronate eye drops group.

Methods: In the walnut moxibustion group, the walnut moxibustion was used, once every two days, 3 times a week, for 4 weeks totally. Read More

Clin Exp Optom 2019 Jan 21. Epub 2019 Jan 21.

School of Optometry and Vision Science, The University of New South Wales, Sydney, New South Wales, Australia.

Smartphone and tablet use in Australia and worldwide is reaching saturation levels and associated visual and ocular discomfort such as headaches, eyestrain, dry eyes and sore eyes are widespread. This review synthesises the available literature and considers these symptoms in the context of a binocular vision and/or ocular surface aetiology. Eye discomfort with smartphones and tablets is discussed alongside similar symptoms reported with desktop computer use. Read More

Int J Biol Macromol 2019 Jan 17;127:440-449. Epub 2019 Jan 17.

School of Chemical Engineering, Northwest University, Xi'an, PR China. Electronic address:

Swelling, mechanical strength, flexibility, and toughness are important parameters in hydrogel preparation for application in the human body. Herein, composite hydrogels were prepared using a mix of Konjac glucomannan (KGM), sodium alginate (SA), and polyvinyl alcohol (PVA) cross-linked by calcium hydroxide. The PVA/KGM/SA composite hydrogel showed a suitable swelling ratio and rate, as well as elasticity and flexibility. Read More

BMC Ophthalmol 2019 Jan 18;19(1):22. Epub 2019 Jan 18.

Department of Ophthalmology, Children's Hospital of Chongqing Medical University, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing, 400014, China.

Background: To identity the effect of lacrimal system irrigation in the acute stage in children with Stevens-Johnson syndrome (SJS) or toxic epidermal necrolysis (TEN).

Methods: A retrospective review of 39 patients with SJS or TEN from 2012 to 2017 was analyzed. Patients were divided into two subgroups according to whether they received irrigation in the acute stage. Read More

Am J Ophthalmol 2019 Jan 14. Epub 2019 Jan 14.

Department of Ophthalmology, Chonnam National University Medical School and Hospital, Gwangju, Korea; Department of Biomedical Sciences and Centers for Creative Biomedical Scientists at Chonnam National University, Gwangju, Korea.

Purpose: To investigate the expression pattern of nucleotide-binding oligomerization domain (Nod)-like receptors that detects "danger" intracellular signaling and its correlation with clinical dry eye (DE) markers.

Design: Cross-sectional study.

Methods: A total of 50 participants with 50 eyes were included; 23 with Sjögren syndrome (SS)-DE, 14 with non-SS-DE, and 13 healthy controls with non-DE. Read More

Adv Clin Exp Med 2019 Jan 14. Epub 2019 Jan 14.

Eye Hospital, Wenzhou Medical University, China.

Background: Dry eye syndrome (DES) is a common symptom of tear film instability and ocular surface damage due to an abnormal quality and quantity of tears, including the sensation of foreign objects and blurred vision. Among all factors for tear film stability, MUC5AC and MUC19 are very important; the levels of both mucins are associated with the pathogenesis of DES.

Objectives: The aim of this study was to explore the expression of MUC5AC and MUC19 on the ocular surface in a DES model of ovariectomized female rabbits. Read More

Br J Ophthalmol 2019 Jan 12. Epub 2019 Jan 12.

Department of Ophthalmology, APHP-Bichat-Claude-Bernard Hospital, Paris, France.

Background/aims: Dry eye disease (DED) is categorised by pathophysiology as aqueous deficient dry eye (ADDE), evaporative dry eye (EDE) or mixed. Treatment should be tailored to DED pathophysiology, but this is challenging to determine. This Delphi consultation aimed to categorise and weight signs and symptoms to help identify the evaporative or aqueous deficient DED origin. Read More

BMC Ophthalmol 2019 Jan 9;19(1):13. Epub 2019 Jan 9.

Department of Ophthalmology, Research Institute of Surgery & Daping Hospital, Army Medical University, Chongqing, 400042, China.

Background: To evaluate the safety and efficacy of a bandage contact lens for alleviating dry eye discomfort after phacoemulsification.

Methods: In this prospective, controlled study, 60 age-related cataract patients with mild Meibomian gland dysfunction (MGD) were randomized to treatment with an ocular bandage contact lens (BCL) (n = 30) or to an untreated control group (n = 30) after phacoemulsification and intraocular lens implantation. The Ocular Surface Disease Index (OSDI) questionnaire, evaluation of subjective symptoms and evaluation of the best-corrected visual acuity (BCVA) were conducted preoperatively and postoperatively on days 1, 7, 14, 30 and 90. Read More

Pharm Res 2019 Jan 7;36(2):36. Epub 2019 Jan 7.

Division of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Missouri, 2464 Charlotte Street, Kansas City, MO, 64108, USA.

Cequa®, a unique and first-in-class preservative free cyclosporine-A (CsA) nanomicellar topical formulation was recently approved by US FDA for treatment of dry eye disease or keratoconjuntivitis sicca (KCS). Being highly hydrophobic, CsA is currently available as an oil based emulsion, which has its own shortcomings. Developing an aqueous and clear formulation of CsA is imperative yet a challenging need in the quest for a safe and better drug product. Read More

Cornea 2019 Mar;38(3):311-317

Department of Ophthalmology, The Eye and ENT Hospital of Fudan University, Shanghai, China.

Purpose: To evaluate sleep and mood status in patients with dry eye disease (DED) and analyze the association between sleep quality, mood status, and ocular surface characteristics.

Methods: Consecutive patients with DED (N = 106) and age- and sex-matched healthy controls (N = 50) were enrolled. Tear fluid break up time (TBUT), corneal fluorescein staining, and Schirmer I tests were performed in the order listed here to evaluate dry eye. Read More

Clin Ophthalmol 2019 21;13:53-62. Epub 2018 Dec 21.

Cornea and Refractive Surgery Service, Instituto de Oftalmologia Conde de Valenciana, I.A.P. Universidad Nacional Autonoma de Mexico, Ciudad de Mexico, Mexico.

Purpose: To analyze potential risk factors for ocular surface damage in a representative population of Mexican patients with dry eye disease (DED).

Patients And Methods: A prospective and cross-sectional population-based epidemiologic cohort study was conducted through a survey of patients with symptoms, signs, known preexisting diagnosis, and clinical conditions related to DED. Fluorescein staining, tear break-up time (TBUT), and Oxford lissamine green staining were performed on both eyes of patients enrolled in the study. Read More

Immunogenetics 2019 Jan 5. Epub 2019 Jan 5.

Department of Clinical Immunology, Children's Hospital of Fudan University, 399 Wanyuan Road, Shanghai, 201102, China.

Deficiency of adenosine deaminase 2 (DADA2) is an autoinflammatory disease caused by autosomal recessive mutations in Cat Eye Syndrome Chromosome Region 1 (CECR1) gene. In this report, we aimed to describe the clinical manifestations, immunological features, genotype, and treatments of one Chinese patient with novel CECR1 gene mutations. This patient initially presented with recurrent fever and rashes from the age of 3 months, but no pathogen was found. Read More

Jpn J Ophthalmol 2019 Jan 2. Epub 2019 Jan 2.

Department of Ophthalmology, Faculty of Medicine Siriraj Hospital, Mahidol University, 2 Wanglang Road, Bangkoknoi, Bangkok, 10700, Thailand.

Purpose: To evaluate and compare tear film changes and ocular symptoms after reading an electronic book (e-book) and a printed book.

Study Design: Clinical and experimental.

Methods: Crossover study was conducted in 30 healthy volunteers, some of whom read an e-book and others a printed book for 20 minutes and then switched the following week. Read More

Cornea 2019 Mar;38(3):318-324

Frontier Medical Science and Technology for Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan.

Purpose: Considering that tears play the role of a lubricant, it is speculated that in the pathophysiology of dry eye, increased friction during blinking results in corneal and conjunctival damage, which may subsequently affect the blink. The purpose of this study was to investigate the relationship between ocular surface epithelial damage, tear abnormalities, and blinks in patients with dry eye.

Methods: This study involved 45 eyes of 45 female patients with dry eye (mean age: 57. Read More

Nurs Womens Health 2019 Feb 27;23(1):71-78. Epub 2018 Dec 27.

Dry eye syndrome is a common ophthalmic complaint. Women, especially menopausal women with comorbidities, are at greater risk for developing dry eye syndrome and subsequent negative effects on their overall eye health. In this article, I review the anatomy and physiology of the ocular surface of the eye, pathophysiology of dry eyes and its complications, risk factors for menopausal women, and assessment tools that nurses can use. Read More

Acta Ophthalmol 2018 Dec 28. Epub 2018 Dec 28.

Department of Ophthalmology, Korea University College of Medicine, Seoul, Korea.

Purpose: To compare the structure and function of the Meibomian gland and eyelid blinking patterns between thyroid eye disease (TED) patients with dry eye and nonthyroidal dry eye (DE) patients.

Methods: This was a prospective, cross-sectional and observational study. Clinical measurements were performed as follows: (1) external examination, (2) Lipiview Interferometer (lipid layer thickness, incomplete blinking rate and meibography) and (3) slit-lamp biomicroscopy (corneal staining, tear break-up time (TBUT), meibum expression). Read More

Scand J Immunol 2018 Nov;88(5):e12718

Department of Clinical Experiment, Changhai Hospital, Second Military Medical University, Shanghai, China.

Objective: IL-35 is a newly discovered immunoregulatory cytokine that possesses the ability to inhibit CD4 + effector T cells and alleviate autoimmune diseases. The objective of this study was to investigate IL-35 levels in patients with primary Sjogren's syndrome (pSS) and explore the roles of IL-35 in the pathogenesis of pSS.

Methods: Thirty-four hospitalized patients with pSS were recruited, and 34 volunteers were enrolled as healthy controls. Read More

PLoS One 2018 26;13(12):e0209558. Epub 2018 Dec 26.

Department of Ophthalmology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan.

Importance: This study provides a nationwide, population-based data on the incidence of benign essential blepharospasm in Asian adults.

Background: To describe the incidence, patient demographics, and risk factors associated with benign essential blepharospasm.

Design: Population-based retrospective study. Read More

Adv Exp Med Biol 2018 ;1085:181-182

Department of Ophthalmology, Columbia University, Edward S. Harkness Eye Institute, NewYork-Presbyterian Hospital, New York, NY, USA.

Glistening yellow-white crystalline inclusions in foveal and parafoveal areas are almost pathognomonic (Fig. 36.1). Read More

Indian J Ophthalmol 2019 Jan;67(1):148-150

Department of Ophthalmology, The University of Texas Medical Branch College of Medicine, Galveston; Department of Ophthalmology, Blanton Eye Institute, Houston Methodist Hospital, Houston; Department of Ophthalmology, Houston Methodist Eye Associates, Houston Methodist Hospital, Houston, TX; Department of Ophthalmology, Weill Cornell Medicine, New York, NY, USA.

A 75-year-old male with a right eye history of chronic dry eye syndrome, glaucoma status post tube shunt, and Fuchs dystrophy status post Descemet stripping endothelial keratoplasty followed by penetrating keratoplasty (PKP) presented with a 2.7 × 4.2 mm corneal ulcer, culture positive for Shewanella algae and Klebsiella oxytoca. Read More

Clin Ophthalmol 2018 10;12:2553-2561. Epub 2018 Dec 10.

Vizzario, Inc., Venice, CA, USA,

Historically, visual acuity has been the benchmark for visual function. It is used to measure therapeutic outcomes for vision-related services, products and interventions. Quantitative measurement of suboptimal visual acuity can potentially be corrected optically with proper refraction in some cases, but in many cases of reduced vision there is something else more serious that can potentially impact other aspects of visual function such as contrast sensitivity, color discrimination, peripheral field of view and higher-order visual processing. Read More

Mol Med Rep 2019 Feb 10;19(2):1056-1064. Epub 2018 Dec 10.

Department of Ophthalmology, Clinical Ophthalmology Institute, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, P.R. China.

The aim of the present study was to investigate the effects of an amniotic membrane lacrimal stent in the treatment of dry eye syndrome in a perimenopausal rabbit model. In total, 48 healthy female rabbits were randomly divided into four groups (12 rabbits/group): Group A, sham‑operated group; group B, negative control group; group C, sham‑implantation group; and group D, implantation with amniotic membrane lacrimal stents. A Schirmer I test (SIT), corneal fluorescein staining, optical coherence tomography angiography and corneal confocal microscopy were conducted and the biomechanical properties of the amniotic membrane were measured prior to and 2, 4 and 6 weeks after the operations. Read More

Graefes Arch Clin Exp Ophthalmol 2019 Feb 14;257(2):331-338. Epub 2018 Dec 14.

Department of Ophthalmology, Chung-Ang University Hospital, College of Medicine, Seoul, South Korea.

Purpose: To determine the effects of botulinum toxin type A (BTX-A) injection on dry eye signs, symptoms, and tear cytokine levels in patients with intractable dry eye disease (DED).

Methods: In this prospective study, patients with intractable DED were randomized to a BTX-A (group A) or control group (group B). Patients were injected with BTX-A or normal saline in the medial part of the upper and lower eyelids. Read More

Sci Rep 2018 Dec 13;8(1):17828. Epub 2018 Dec 13.

Department of Ophthalmology, the First Affiliated Hospital of Nanchang University, Nanchang, 330006, Jiangxi Province, China.

In this study, we explored the effects of particulate matter 2.5 (PM) eye drops on the ocular surface structure and tear function in mice and established a novel animal model for dry eye research. We found that, following treatment with PM, the tear volume and, the tear film break-up time showed statistical differences at each time point (P < 0. Read More

Consult Pharm 2018 Dec;33(12):691-701

: Review the clinical manifestations and treatment of primary Sjögren's syndrome. : Articles indexed in PubMed, Scopus, and the Cochrane Library in the past 10 years using the key words "Sjögren," "Sjögren's syndrome," "Sjögren's disease," and "Sjögren's syndrome AND treatment." Primary sources were used to locate additional resources. Read More

Int J Mol Sci 2018 Dec 8;19(12). Epub 2018 Dec 8.

Ribeirao Preto Medical School, Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, SP 14049-900 Brazil.

For decades, neurological, psychological, and cognitive alterations, as well as other glandular manifestations (EGM), have been described and are being considered to be part of Sjögren's syndrome (SS). Dry eye and dry mouth are major findings in SS. The lacrimal glands (LG), ocular surface (OS), and salivary glands (SG) are linked to the central nervous system (CNS) at the brainstem and hippocampus. Read More

Medicine (Baltimore) 2018 Dec;97(49):e13528

First Clinical Medical College of Nanjing Medical University.

Background: Helicobacter pylori has been proved as a risk factor of many diseases. There are some researches trying to find connection between H. pylori and Sjögren syndrome (SS). Read More

Brain Nerve 2018 Dec;70(12):1389-1396

Department of Neurology, Japanese Red Cross Yamaguchi Hospital.

A 31-year-old woman was admitted to the hospital after several episodes of transient numbness in her fingers and dysarthria. No neurological symptoms and signs were observed in this patient on admission; however, blood tests revealed elevated amylase and immunoglobulin G levels, an increased erythrocyte sedimentation rate, and positive anti-Sjögren's-syndrome (SjS)-related antigen A antibodies. The cerebrospinal fluid examination revealed a slight increase in the cell count and protein content. Read More

Methods Mol Biol 2019 ;1901:103-112

UCLA School of Dentistry, Los Angeles, CA, USA.

Primary Sjögren's syndrome (pSS) is a systemic autoimmune disease marked by dry mouth/dry eye symptoms as a result of the destruction of the salivary and lacrimal glands. Patients with pSS may be at risk for the development of mucosa-associated lymphoid tissue (MALT) lymphoma. Testing of autoantibodies in the oral fluid of patients with pSS or MALT lymphoma using immunoassays may lead to a simple and noninvasive clinical tool for diagnostic or prognostic applications. Read More

Cornea 2019 Mar;38(3):304-310

Department of Ophthalmology, Hallym University College of Medicine, Seoul, Korea.

Purpose: To investigate the efficacy of topical carbomer-based lipid-containing artificial tears (CLAT) and hyaluronate (HU) in patients with dry eye disease (DED) based on serum 25-hydroxyvitamin D (25HD) levels and cholecalciferol (vitamin D) supplementation.

Methods: A total of 116 patients with DED from June 2015 to June 2016 were included. The participants were divided into the vitamin D deficiency (VDD) group and the non-VDD group according to their serum 25HD levels. Read More

PLoS One 2018 3;13(12):e0208420. Epub 2018 Dec 3.

Department of Ophthalmology, Otorhinolaryngology and Head & Neck Surgery, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.

Purpose: Dry Eye Disease (DED) is part of several conditions, including Sjögren's syndrome (SS) and no single test to diagnosis DED. The present study intends to evaluate whether a set of signs and symptoms of DED can distinguish: a) SS from other non-overlapping systemic diseases related to DED; b) primary and secondary SS.

Methods: 182 consecutive patients with DED were evaluated under five groups: SS, graft-versus-host disease (GVHD), Graves' orbitopathy (GO), diabetes mellitus (DM), glaucoma under treatment with benzalkonium chloride medications (BAK). Read More

Georgian Med News 2018 Oct(283):39-43

Corporate Foundation «University Medical Center»; JSC «Medical University of Astana», Republic of Kazakhstan, Georgia.

The purpose of the study is a comparative analysis of the efficacy and safety of the Femto LASIK and ReLEx SMILE technologies in correcting myopic astigmatism. Materials and methods: The study included 1212 results of interventions in patients with myopic astigmatism, incl. 721 (59. Read More

BMC Ophthalmol 2018 Dec 4;18(1):309. Epub 2018 Dec 4.

Doheny Image Reading Center, Doheny Eye Institute, 1355 San Pablo Street, Los Angeles, CA, 90033, USA.

Background: The corneal epithelium is directly affected in dry eye syndrome. Thus, we attempted to describe the morphological features and evaluate the cellular density within the corneal epithelial layers in patients with non-Sjögren's (NSDE) and Sjögren's syndrome dry eyes (SSDE) by in vivo confocal microscopy (IVCM).

Methods: Central cornea was prospectively imaged by IVCM in 68 clinically diagnosed aqueous tear-deficient dry eyes and 10 healthy age-matched control eyes. Read More

Int J Nanomedicine 2018 8;13:7251-7273. Epub 2018 Nov 8.

Graduate Institute of Biomedical Materials and Tissue Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei City, Taiwan,

Introduction: Dry-eye syndrome (DES) is a general eye disease. Eye drops are the common ophthalmological medication. However, the ocular barrier makes it difficult to attain high drug bioavailability. Read More

Clin Ophthalmol 2018 8;12:2277-2283. Epub 2018 Nov 8.

Center for Sight, Sarasota, FL, USA,

Purpose: A new cross-linked hyaluronic acid (xlHA) gel occlusive device was assessed for safety and efficacy in the treatment of dry eyes.

Methods: This was an institutional review board-approved, single-site, open-label, prospective study to assess the efficacy and safety of placing the xlHA gel in the lower canaliculus. Seventy-four participants aged 25-95 years with dry eyes, who failed treatment with artificial tears, were included. Read More

Curr Eye Res 2018 Nov 30. Epub 2018 Nov 30.

a Department of Ophthalmology , Ege University School of Medicine , Izmir , Turkey.

Purpose: To evaluate the ocular surface and meibography of patients with inactive Behçet's uveitis.

Methods: Twenty-five right eyes of 25 patients with inactive Behçet's uveitis (Group 1) and 25 right eyes of 25 healthy individuals (Group 2) were enrolled. Detailed eye examination along with Schirmer 1 test, tear film break-up time (t-BUT), ocular surface staining with fluorescein and Oxford scoring, ocular surface disease index (OSDI) score assessment were performed. Read More

Vestn Oftalmol 2018 ;134(5):126-134

Saint Petersburg State Pediatric Medical University, 2 Litovskaya St., Saint Petersburg, Russian Federation, 194100; Mariinsky City Hospital, 56 Liteinyi Prospect, Saint Petersburg, Russian Federation, 194104.

In current understanding of the pathogenesis of xerotic changes of the ocular surface in patients with dry eye syndrome (DES), great importance is given to hyperosmolarity of the tear film, inflammatory process and oxidative stress. By now, no convincing data has been obtained on whether the oxidative stress is primary in relation to the inflammatory process in the ocular surface tissues, or if it is a complication. Furthermore, in the complex treatment of patients with DES, antioxidant therapy has so far received little attention. Read More

Vestn Oftalmol 2018 ;134(5. Vyp. 2):294-298

I.M. Sechenov First Moscow State Medical University, Chair of Ophthalmology, 8-2 Malaya Trubetskaya St., Moscow, Russian Federation, 119991.

The article reviews the particularities of development and pathogenesis of secondary dry eye syndrome (DES) after refractive surgeries including a complex of problems related to changes in tear film content, damage of eye surface and neurotrophic epitheliopathy. Additionally, modern algorithms of treatment and prevention of secondary DES in patients after refractive surgeries are described. Despite the transient nature of the changes, excimer-laser surgery can lead to lasting deficiencies of eye surface in some patients. Read More