19,839 results match your criteria Dry Eye Syndrome


Ocular Surface Disorders in Patients with Human Immunodeficiency Virus (HIV) Infection.

Ocul Immunol Inflamm 2020 Jun 5:1-7. Epub 2020 Jun 5.

Singapore Eye Research Institute , Singapore, Singapore.

Purpose: To describe ocular surface disorders associated with human immunodeficiency virus (HIV). : Narrative review. : Ocular surface neoplastic conditions, such as Kaposi's sarcoma, conjunctival lymphoma and ocular squamous cell carcinoma along with blepharitis, dry eye disease, and vernal keratoconjunctivitis, constitute ocular surface complications in HIV-infected individuals. Read More

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http://dx.doi.org/10.1080/09273948.2020.1757122DOI Listing

Association Between Dry Eye and Polycystic Ovary Syndrome: Subclinical Inflammation May Be Part of the Process.

Eye Contact Lens 2020 Jun 1. Epub 2020 Jun 1.

Departments of Ophthalmology (Y.A., M.A.), and Obstetrics and Gynecology (Ö.K.), Hitit University Erol Olcok Education and Research Hospital, Corum, Turkey; and Department of Obstetrics and Gynecology (E.B.), Yozgat Bozok University, Yozgat, Turkey.

Purpose: To evaluate the changes in tear function in patients with polycystic ovary syndrome (PCOS) and establish whether there is a correlation between hormonal levels, novel hematologic biomarkers, and dry eye parameters.

Material And Method: Forty-seven patients with PCOS and 43 age-matched patients with unexplained infertility were included in the control group. Follicle-stimulating hormone, luteinizing hormone, estradiol, thyroid-stimulating hormone, prolactin, dehydroepiandrosterone sulfate (DHEA-S), 17-OH progesterone, fasting and postprandial glucose, fasting insulin, and cholesterol metabolites were evaluated in both groups. Read More

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http://dx.doi.org/10.1097/ICL.0000000000000716DOI Listing

Correlation Analysis between Ocular Surface Parameters with Subjective Symptom Severity in Dry Eye Disease.

Korean J Ophthalmol 2020 Jun;34(3):203-209

Nune Eye Hospital, Seoul, Korea.

Purpose: To evaluate the clinical symptoms of patients with dry eyes, based on the ocular surface disease index (OSDI) and analyze the relationship between OSDI and various ocular surface parameters.

Methods: This was a retrospective study that included 45 eyes of 45 dry eye patients who visited the Seoul Nune Eye Hospital from August 2017 to December 2017. The patients were assessed by non-invasive keratography for the first break-up time, lipid layer thickness (LLT), tear osmolarity, tear matrix metalloproteinase-9 immunoassay as well as with the conventional Schirmer I test and fluorescein break-up time. Read More

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http://dx.doi.org/10.3341/kjo.2019.0133DOI Listing

Tear Osmolarity and Matrix Metallopeptidase-9 in Dry Eye Associated with Sjögren's Syndrome.

Korean J Ophthalmol 2020 Jun;34(3):179-186

Department of Ophthalmology, Chonnam National University Hospital, Chonnam National University Medical School, Gwangju, Korea.

Purpose: To evaluate the correlations between tear osmolarity and matrix metallopeptidase-9 (MMP-9) and dry eye (DE) indices in patients with DE associated with Sjögren's syndrome (SS).

Methods: Sixty-three patients with DE associated with SS who underwent tear analysis were included. DE tests performed were ocular surface disease index, tear break-up time, Schirmer's test, ocular staining score, and tear osmolarity and MMP-9 tests. Read More

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http://dx.doi.org/10.3341/kjo.2019.0145DOI Listing

Hyaluronic Acid-Pluronic®F127-Laden Soft Contact Lenses for Corneal Epithelial Healing: In Vitro and In Vivo Studies.

AAPS PharmSciTech 2020 Jun 2;21(5):162. Epub 2020 Jun 2.

Refractive Surgery Center, The Second People's Hospital of Jinan, No. 148, Jingyi Road, Huaiyin District, Jinan, 250022, Shandong Province, China.

Hyaluronic acid (HA) is widely used to treat various ocular diseases like dry eye syndrome, keratoconus, and other corneal epithelial injuries. The currently available eye drop solutions need frequent doses affecting the routine life style of patients. In this work, the silicone contact lens was designed to entrap HA and Pluronic®F127 to improve the wettability of the contact lens to treat various ocular diseases. Read More

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http://dx.doi.org/10.1208/s12249-020-01714-zDOI Listing

Oculoplastic considerations for refractive procedures.

Curr Opin Ophthalmol 2020 Jul;31(4):241-246

Department of Ophthalmology and Visual Sciences, Montefiore Medical Center, Albert Einstein College of Medicine, New York City, New York, USA.

Purpose Of Review: Refractive surgery is one of the most popular elective procedures performed in the world. Given that dry eye is a common complaint following keratorefractive surgery, evaluation, and treatment of periocular conditions that further predispose the patient to dry eye symptoms is an important part of the presurgical assessment. Periocular conditions and surgeries can also affect the ocular surface and keratometry, and should be addressed. Read More

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http://dx.doi.org/10.1097/ICU.0000000000000667DOI Listing

A Novel Selective 11β-HSD1 Inhibitor, (E)-4-(2-(6-(2,6-Dichloro-4-(Trifluoromethyl)Phenyl)-4-Methyl-1,1-Dioxido-1,2,6-Thiadiazinan-2-yl)Acetamido)Adamantan-1-Carboxamide (KR-67607), Prevents BAC-Induced Dry Eye Syndrome.

Int J Mol Sci 2020 May 25;21(10). Epub 2020 May 25.

Therapeutics & Biotechnology Division, Korea Research Institute of Chemical Technology, 141 Gajeong-ro, Yuseong-gu, Daejeon 34114, Korea.

Dry eye syndrome is the most common eye disease and it is caused by various reasons. As the balance of the tear film that protects the eyes is broken due to various causes, it becomes impossible to properly protect the eyes. In this study, the protective effects and underlying mechanisms of topical (E)-4-(2-(6-(2,6-dichloro-4-(trifluoromethyl)phenyl)-4-methyl-1,1-dioxido-1,2,6-thiadiazinan-2-yl)acetamido)adamantan-1-carboxamide (KR-67607), a novel selective 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1) inhibitor, were investigated in benzalkonium chloride (BAC)-induced dry eye syndrome. Read More

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http://dx.doi.org/10.3390/ijms21103729DOI Listing

Trehalose for Ocular Surface Health.

Biomolecules 2020 May 25;10(5). Epub 2020 May 25.

Department of Ophthalmology, Institute of Clinical Medicine, University of Eastern Finland, FI-70210 Kuopio, Finland.

Trehalose is a natural disaccharide synthesized in various life forms, but not found in vertebrates. An increasing body of evidence demonstrates exceptional bioprotective characteristics of trehalose. This review discusses the scientific findings on potential functions of trehalose in oxidative stress, protein clearance, and inflammation, with an emphasis on animal models and clinical trials in ophthalmology. Read More

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http://dx.doi.org/10.3390/biom10050809DOI Listing

Commentary: Dry eye syndrome and vitamin D deficiency.

Indian J Ophthalmol 2020 Jun;68(6):1026-1027

ASG Eye Hospital, Kolkata, West Bengal, India.

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http://dx.doi.org/10.4103/ijo.IJO_398_20DOI Listing

The use of tear ferning test in cats for evaluation of ocular surface.

Acta Vet Scand 2020 May 26;62(1):23. Epub 2020 May 26.

Department of Agrarian and Environmental Sciences, Santa Cruz State University, Rodovia Jorge Amado, Ilheus, Bahia, 45662-900, Brazil.

Background: The tear film is a trilaminar fluid composed mainly of lipids, electrolytes, proteins and water. It is responsible for lubrication, nutrition and protection against microbial and toxic agents. Disruption of any these components may weaken the ocular surface, making it more susceptible to disease. Read More

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http://dx.doi.org/10.1186/s13028-020-00523-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7248460PMC

Sicca Symptoms, Oral Health Conditions, Salivary Flow and Oral in Sjögren's Syndrome Patients.

Int J Environ Res Public Health 2020 May 21;17(10). Epub 2020 May 21.

Department of Medicine, Queen Elizabeth Hospital, Hong Kong SAR, Hong Kong.

This study aimed to investigate the relationships among sicca symptoms, oral health conditions, salivary profiles and oral Candida in Sjögren's syndrome (SS) patients. Eighty-five SS patients (mean age = 50.5) and 40 healthy non-SS individuals (mean age = 51. Read More

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http://dx.doi.org/10.3390/ijerph17103625DOI Listing

Risk factors associated with severity of dry eye syndrome in ocular graft-versus-host disease.

Can J Ophthalmol 2020 May 18. Epub 2020 May 18.

Department of Ophthalmology and Visual Sciences, University of British Columbia, Vancouver, B.C.. Electronic address:

Objective: The aim of this study was to identify risk factors for the development of severe dry eye syndrome (DES) in patients with ocular graft-versus-host disease (oGVHD).

Design: Retrospective Chart Review.

Participants: Patients undergoing allogeneic hematopoietic stem cell transplantation at the British Columbia Cancer Agency between 2011 and 2013. Read More

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http://dx.doi.org/10.1016/j.jcjo.2020.04.013DOI Listing

Histopathological changes in tear-secreting tissues and cornea in a mouse model of autoimmune disease.

Exp Biol Med (Maywood) 2020 May 21:1535370220928275. Epub 2020 May 21.

Laboratory of Anatomy, Department of Basic Veterinary Sciences, Faculty of Veterinary Medicine, Hokkaido University, Sapporo 060-0618, Japan.

Impact Statement: Cornea, an outermost layer of mammalian eye, is protected by tear film and abnormalities of tear film causes dry eye. Dry eye injures the cornea which results lower vision in patients. Several factors cause dry eye, including altered systemic conditions, environment, and immunological abnormality of the patient in autoimmune disease like Sjögren's syndrome (SS). Read More

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http://dx.doi.org/10.1177/1535370220928275DOI Listing

[Inflammation in Dry Eye Disease - Information on Diagnostic Testing and Therapy Using the Scientific Online Information Platform OSCB-Berlin.org].

Klin Monbl Augenheilkd 2020 May 20;237(5):627-636. Epub 2020 May 20.

OSCB, Ocular Surface Center Berlin.

Dry eye is considered the most common disease in ophthalmology. In recent decades, there has been intensive clinical and experimental research on this condition and our scientific knowledge of its pathophysiology has greatly expanded. The disease may be simple or severe and may lead to complex deregulation of the functional anatomy of the ocular surface, typically with a disparity between the clinical findings and the patient's symptoms. Read More

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http://dx.doi.org/10.1055/a-1155-6556DOI Listing

Myopic regression and recurrent Salzmann nodule degeneration after laser in situ keratomileusis in Ehlers Danlos Syndrome.

Am J Ophthalmol Case Rep 2020 Sep 4;19:100729. Epub 2020 May 4.

Hoopes Durrie Rivera Research Center, Hoopes Vision; 11820 State St, Draper, UT, 84020, USA.

Purpose: We describe the first case of Ehlers Danlos Syndrome (EDS) reported in the English language ophthalmic literature to have undergone Laser In Situ Keratomileusis (LASIK) surgery.

Observations: We review our patient's specific postoperative complications of myopic regression, Salzmann nodular degeneration, and dry eye syndrome, as well as the risks and consequences of performing LASIK on patients with this collagen disorder.

Conclusions And Importance: Refractive errors may prompt EDS patients to seek laser vision correction, placing them at increased risk for complications such as myopic regression, keratectasia, and dry eye syndrome. Read More

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http://dx.doi.org/10.1016/j.ajoc.2020.100729DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7225616PMC
September 2020

Vitamin D deficiency is associated with dry eye syndrome: a systematic review and meta-analysis.

Acta Ophthalmol 2020 May 18. Epub 2020 May 18.

Clinical College of Ophthalmology, Tianjin Medical University, Tianjin, China.

A systematic review and meta-analysis was conducted to determine the association between the serum vitamin D level and dry eye. A systematic literature search was performed using the PubMed, Embase, Web of Science and Cochrane Library databases to identify clinical studies evaluating the association between vitamin D levels and dry eye. The random-effect model was used to combine the results. Read More

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http://dx.doi.org/10.1111/aos.14470DOI Listing

Therapeutic benefits of blinking exercises in dry eye disease.

Cont Lens Anterior Eye 2020 May 11. Epub 2020 May 11.

Department of Ophthalmology, New Zealand National Eye Centre, The University of Auckland, New Zealand. Electronic address:

Purpose: Dry eye disease (DED) is an important public health concern given its increasing prevalence and impact on patient quality of life. Blinking frequency and completeness are reduced during digital screen exposure, compromising meibum secretion and distribution, causing tear film instability and leading to DED. This study evaluated the effects of blinking exercises on blink pattern and clinical signs and symptoms of DED. Read More

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http://dx.doi.org/10.1016/j.clae.2020.04.014DOI Listing

Ocular Findings in Pontine Tegmental Cap Dysplasia.

Cornea 2020 May 11. Epub 2020 May 11.

Department of Ophthalmology, University of Colorado School of Medicine, Aurora, CO.

Purpose: To describe the ocular complications experienced by patients with pontine tegmental cap dysplasia (PTCD) and the management strategies used to care for these children.

Methods: Subjects with PTCD were recruited through social media advertisement and completed a survey gathering information on potential ocular problems related to the patient's PTCD disease and any current or previous treatments.

Results: Twenty-two patients or guardians completed the survey. Read More

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http://dx.doi.org/10.1097/ICO.0000000000002361DOI Listing

Immunobiology of T Cells in Sjögren's Syndrome.

Clin Rev Allergy Immunol 2020 May 11. Epub 2020 May 11.

Digestive Disease Institute, Guangzhou First People's Hospital and Institutes for Life Sciences, South China University of Technology, Guangzhou, 510006, China.

Sjögren's syndrome (SjS) is a systemic autoimmune disease marked by xerostomia (dry mouth), keratoconjunctivitis sicca (eye dryness), and other systematic disorders. Its pathogenesis involves an inflammatory process that is characterized by lymphocytic infiltration into exocrine glands and other tissues. Although the development of ectopic lymphoid tissue and overproduction of autoantibodies by hyperactive B cells suggest that they may promote SjS development, treatment directed towards them fails to induce significant laboratory or clinical improvement. Read More

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http://dx.doi.org/10.1007/s12016-020-08793-7DOI Listing

Dry anophthalmic socket syndrome - Standardized clinical evaluation of symptoms and signs.

Ocul Surf 2020 Jul 6;18(3):453-459. Epub 2020 May 6.

Department of Ophthalmology, University of Cologne, Faculty of Medicine and University Hospital of Cologne, Cologne, Germany; Center for Integrated Oncology (CIO) Aachen-Bonn-Cologne-Dusseldorf, Cologne, Germany.

Objectives: To assess symptoms and signs of the dry anophthalmic socket syndrome (DASS) in a standardized manner.

Methods: 87 unilateral anophthalmic patients were evaluated using the Ocular Surface Disease Index (OSDI), the 5-Item Dry Eye Questionnaire (DEQ-5), and a modified version of Symptom Assessment iN Dry Eye (SANDE) questionnaire separately for the anophthalmic socket and for the healthy fellow eye. Conjunctival inflammation was semi-quantitatively graded and Schirmer I test with topical anesthesia was performed bilaterally. Read More

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http://dx.doi.org/10.1016/j.jtos.2020.05.001DOI Listing

Sustained subconjunctival drug delivery systems: current trends and future perspectives.

Int Ophthalmol 2020 May 5. Epub 2020 May 5.

Department of Ophthalmology, Imam Hassan University Hospital, Alborz University of Medical Sciences, Karaj, Iran.

Purpose: One of the challenges of ocular drug delivery systems is sustainable delivery of the intended drug to the posterior segment of the eye. Periocular routes of drug delivery are a promising method to bridge this challenge. The purpose of this study is to investigate the recent advances and potentials of subconjunctival route and its pros and cons in comparison with other ocular drug delivery routes. Read More

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http://dx.doi.org/10.1007/s10792-020-01391-8DOI Listing

Arabinogalactan and hyaluronic acid in ophthalmic solution: Experimental effect on xanthine oxidoreductase complex as key player in ocular inflammation (in vitro study).

Exp Eye Res 2020 May 4;196:108058. Epub 2020 May 4.

Department of Research & Development, MD Italy, Via Cancelliera 12, 00041, Albano Laziale, Rome, Italy.

Dry eye syndrome is a common disease associated to eyes inflammation, irritation and tear film instability. The enzymatic complex of xanthine oxidoreductase (XOR) is involved in the generation of reactive oxygen species (ROS) and uric acid that, in the end, can cause reperfusion injuries, irritation and pathological conditions. Furthermore, in the eye, it has been proposed that oxygen free radicals might play a significant role in retinal ischemic damage. Read More

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http://dx.doi.org/10.1016/j.exer.2020.108058DOI Listing

Prevalence and risk factors of dry eye in 79,866 participants of the population-based Lifelines cohort study in the Netherlands.

Ocul Surf 2020 May 4. Epub 2020 May 4.

Section of Academic Ophthalmology, School of Life Course Sciences, Faculty of Life Sciences and Medicine (FoLSM), King's College London, St Thomas' Hospital, Lambeth Palace Road, Waterloo, London, SE1 7EH, United Kingdom; Department of Ophthalmology, King's College London, St Thomas' Hospital, Lambeth Palace Road, Waterloo, London, SE1 7EH, London, United Kingdom.

Purpose: To investigate the prevalence of dry eye among all adult age categories and to discover independent risk factors by investigating a wide range of etiological categories.

Methods: A cross-sectional association study including 79,866 voluntary participants aged 20-94 years of the population-based Lifelines Cohort Study in the Netherlands.

Results: Overall, 9. Read More

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http://dx.doi.org/10.1016/j.jtos.2020.04.005DOI Listing

Relationships Between Short-Term Exposure to an Indoor Environment and Dry Eye (DE) Symptoms.

J Clin Med 2020 May 2;9(5). Epub 2020 May 2.

Environmental Health Division, University of Miami, Miami, FL 33136, USA.

Air composition influences Dry Eye (DE) symptoms as demonstrated by studies that have linked the outdoor environment to DE. However, there is insufficient data on the effect of short-term exposure to indoor environments on DE symptoms. We conducted a prospective experimental research, in which an older building served as an experimental site, and a newer building served as the control site. Read More

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http://dx.doi.org/10.3390/jcm9051316DOI Listing

miR-744-5p contributes to ocular inflammation in patients with primary Sjogrens Syndrome.

Sci Rep 2020 May 4;10(1):7484. Epub 2020 May 4.

Department of Ophthalmology, Royal College of Surgeons in Ireland, Dublin 2, Ireland.

In primary Sjögren's syndrome (pSS) the exocrine glands become infiltrated with lymphocytes instigating severe damage to the salivary and lacrimal glands causing dry eyes and dry mouth. Previous investigations have suggested that dysregulated localized and systemic inflammation contributes to the development and pathogenesis of pSS. A miR microarray performed in primary human conjunctival epithelial cells (PECs) demonstrated significant differences in miR expression at the ocular surface between pSS patients and healthy controls. Read More

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http://dx.doi.org/10.1038/s41598-020-64422-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7198540PMC

[Treatment of chronic posterior blepharitis after allogeneic hematopoietic stem cell transplantation (a case report)].

Vestn Oftalmol 2020 ;136(2):86-92

Research Institute of Eye Diseases, Moscow, Russia.

After allogeneic hematopoietic stem cell transplantation (allo-HSCT), various eye diseases are detected in 30-60% of patients, with chronic graft-versus-host reaction - in 50-90% of patients. Among the complications, the most frequent is damage to the eye surface and eyelids. The article presents a clinical case of successful minimally invasive treatment of chronic posterior blepharitis in a patient who has undergone allogeneic hematopoietic stem cell transplantation. Read More

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http://dx.doi.org/10.17116/oftalma202013602186DOI Listing
January 2020

[The effect of the tear film on the results of a direct assessment of the sensitivity of the cornea].

Vestn Oftalmol 2020 ;136(2):81-85

Research Institute of Eye Diseases, Moscow, Russia.

Attempts to find clinical application for esthesiometry are associated with studying sensitivity disorders that occur in various diseases (diabetes mellitus, keratitis of various etiologies, corneal erosion, dry eye syndrome), as well as after surgical interventions.

Purpose: To evaluate the influence of the tear film on the results of direct assessment of corneal sensitivity.

Material And Methods: The study was conducted in a group of 20 healthy volunteers. Read More

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http://dx.doi.org/10.17116/oftalma202013602181DOI Listing
January 2020

[Effectiveness of antihypertensive conservative-free therapy with fixed combination of bimatoprost and timolol (intermediate results)].

Vestn Oftalmol 2020 ;136(2):73-80

South Ural State Medical University, Chelyabinsk, Russia.

Introduction: The effects of antihypertensive therapy are often determined by patient compliance with the prescribed treatment plan. Acceptance of conservative-free forms of drugs leads to a decrease in the frequency and severity of side effects, reduces the need for the use of artificial tears, which lowers the cost of treatment for the patients.

Purpose: to evaluate the hypotensive effectiveness of a fixed combination of bimatoprost (0. Read More

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http://dx.doi.org/10.17116/oftalma202013602173DOI Listing
January 2020

Clinical Characteristics of Secondary Immune Thrombocytopenia Associated With Primary Sjögren's Syndrome.

Front Med (Lausanne) 2020 17;7:138. Epub 2020 Apr 17.

Department of Rheumatology and Clinical Immunology, The First Affiliated Hospital of Xiamen University, Xiamen, China.

Clinical characteristics of immune thrombocytopenia (ITP) associated with primary Sjögren's syndrome (pSS) have not been clearly defined. This study aimed to evaluate the prevalence and clinical characteristics of secondary ITP in patients with pSS. 291 pSS patients in our hospital were retrospectively analyzed. Read More

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http://dx.doi.org/10.3389/fmed.2020.00138DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7181055PMC

RvE1 uses the LTB receptor BLT1 to increase [Ca] and stimulate mucin secretion in cultured rat and human conjunctival goblet cells.

Ocul Surf 2020 Jul 30;18(3):470-482. Epub 2020 Apr 30.

Schepens Eye Research Institute, Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston, MA, USA. Electronic address:

Purpose: Specialized pro-resolving lipid mediator resolvin (Rv) E1 stimulates secretion including mucins from conjunctival goblet cells. RvE1 can use both its ChemR23 receptor and the LTB receptor BLT1 to increase [Ca]. The purpose of this study was to determine the expression of ChemR23 and BLT1 and receptors on conjunctival goblet cells and the respective roles these two receptors play in goblet cell responses to RvE1. Read More

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http://dx.doi.org/10.1016/j.jtos.2020.04.011DOI Listing

Clinical significance of progranulin correlated with serum soluble Oxford 40 ligand in primary Sjögren's syndrome.

Medicine (Baltimore) 2020 May;99(18):e19967

Department of Rheumatism and Immunology, The Second Hospital of Hebei Medical University, Shijiazhuang, P.R. China.

The present study aimed to investigate the association between the expressions of serum progranulin (PGRN) and serum soluble Oxford 40 ligand (sOX40L) and determine their clinical significances in primary Sjögren's syndrome (pSS).The present study included a total of 68 patients with pSS and 50 healthy controls. Demographic data and clinical basic information were collected. Read More

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http://dx.doi.org/10.1097/MD.0000000000019967DOI Listing

Ocular manifestations in rheumatoid arthritis, connective tissue disease and vasculitis: a systematic review and meta-analysis.

J Rheumatol 2020 May 1. Epub 2020 May 1.

From the Schulich School of Medicine, University of Western Ontario, St. Joseph's Health Care, London, Ontario, Canada; University of Toronto, Toronto, Ontario, Canada; Canadian Rheumatology Association Research studentship, University of Western Ontario. This funding was supported through the Canadian Rheumatology Association Roche summer studentship. There are no conflicts of interest. IRB was not necessary as this was a systematic literature review. Address correspondence to Dr. Janet Pope MD MPH FRCPC, Division of Rheumatology, St. Joseph's Health Care, 268 Grosvenor St. London ON N6A 4V2,

Objective: Rheumatoid Arthritis and other rheumatic diseases may present with ocular manifestations. The purpose of our work was to determine the prevalence and type of eye involvement in rheumatoid arthritis and other connective tissue diseases through a meta-analysis and literature review.

Methods: A systematic review of the literature was performed using Medline, Web of Science, and the Cochrane library from their inceptions until January 7, 2019. Read More

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http://dx.doi.org/10.3899/jrheum.190768DOI Listing

[Assessment of the incidence of dry eye syndrome symptoms in Military Police soldiers serving outside the country].

Pol Merkur Lekarski 2020 Apr;48(284):82-86

Medical University of Lodz, Poland.

Dry eye syndrome (DES) is caused by insufficient tear production, excessive evaporation or tear film instability. It causes damage to the anterior surface of the eye in the form of dry conjunctivitis and even visual disturbances. In recent years, awareness has increased that DES is a significant medical problem and its symptoms are a common cause of discomfort reported by patients. Read More

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Active matter therapeutics.

Nano Today 2020 Apr 27;31. Epub 2020 Feb 27.

Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, Maryland 21218, USA.

Nanotherapies based on micelles, liposomes, polymersomes, nanocapsules, magnetic nanoparticles, and noble metal nanoparticles have been at the forefront of drug delivery in the past few decades. Some of these nanopharmaceuticals have been commercially applied to treat a wide range of diseases, from dry eye syndrome to cancer. However, the majority involve particles that are passive, meaning that they do not change shape, and they lack motility; the static features can limit their therapeutic efficacy. Read More

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http://dx.doi.org/10.1016/j.nantod.2019.100836DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7188019PMC

Evaluation of ocular symptoms and tropism of SARS-CoV-2 in patients confirmed with COVID-19.

Acta Ophthalmol 2020 Apr 26. Epub 2020 Apr 26.

The Department of Ophthalmology, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.

Purpose: The SARS-CoV-2 RNA has been detected in tears and conjunctival samples from infected individuals. Conjunctivitis is also reported in a small number of cases. We evaluated ocular symptoms and ocular tropism of SARS-CoV-2 in a group of patients with COVID-19. Read More

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http://dx.doi.org/10.1111/aos.14445DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7267628PMC

An investigation of low power convex lenses (adds) for eyestrain in the digital age (CLEDA).

J Optom 2020 Apr 22. Epub 2020 Apr 22.

Neville Chappell Research Clinic, Institute of Optometry, 56-62 Newington Causeway, London, SE1 6DS, UK; Division of Optometry & Visual Sciences, City, University of London, Northampton Square, London, EC1V 0HB, UK. Electronic address:

Introduction: Digital eye strain (DES; computer vision syndrome) is a common cause of symptoms when viewing digital devices. Low-powered convex lenses (adds) have been recommended for the condition and "accommodative support" designs developed on this premise. The present research reports the extent to which dry eye is present in this population and the effect of convex lenses on symptoms and visual performance. Read More

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http://dx.doi.org/10.1016/j.optom.2019.12.006DOI Listing

The effects of adjuvant hormonotherapy on tear functions in patients with breast cancer.

Int Ophthalmol 2020 Apr 24. Epub 2020 Apr 24.

Department of Ophthalmology, Saglik Bilimleri University, Dışkapı Yıldırım Beyazıt Training and Research Hospital, Ankara, Turkey.

Purpose: Aromatase inhibitors (anastrozole, letrozole) and selective estrogen receptor modulators (tamoxifen) are widely used as adjuvant hormonal therapy in women with hormone receptor-positive breast cancer. We aimed to evaluate the effects of oral adjuvant hormonotherapy on tear functions in patients with breast cancer.

Methods: In this case-control study, we enrolled eligible patients with breast cancer who were receiving regular medical selective estrogen receptor modulator (tamoxifen, n:50), aromatase inhibitors (anastrozole, letrozole, n:50) and gender-matched healthy controls (n:50). Read More

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http://dx.doi.org/10.1007/s10792-020-01384-7DOI Listing

A Multivalent ICAM-1 Binding Nanoparticle which Inhibits ICAM-1 and LFA-1 Interaction Represents a New Tool for the Investigation of Autoimmune-Mediated Dry Eye.

Int J Mol Sci 2020 Apr 15;21(8). Epub 2020 Apr 15.

Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, CA 90033, USA.

The autoimmune disorder, Sjögren's syndrome (SS), is characterized by lymphocytic infiltration and loss of function of exocrine glands such as the lacrimal gland (LG) and salivary gland. SS-associated changes in the LG are associated with the development of autoimmune-mediated dry eye disease. We have previously reported the accumulation of intercellular adhesion molecule 1 (ICAM-1) in the LG of Non-Obese Diabetic (NOD) mice, a murine model of autoimmune-mediated dry eye in SS, in both LG acinar cells and infiltrating lymphocytes. Read More

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http://dx.doi.org/10.3390/ijms21082758DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7216292PMC

Aberrant HLA-DR expression in the conjunctival epithelium after autologous serum treatment in patients with graft-versus-host disease or Sjögren's syndrome.

PLoS One 2020 21;15(4):e0231473. Epub 2020 Apr 21.

Laboratory of the Biology and Pathology of the Eye, Institute of Biology and Medical Genetics, First Faculty of Medicine, Charles University and General University Hospital in Prague, Prague, Czech Republic.

The aim of this study was to determine the effect of autologous serum (AS) eye drops on the density of human leucocyte antigen (HLA)-DR-positive epithelial cells and Langerhans cells on the ocular surface of patients with bilateral severe dry eye disease (DED) due to graft-versus-host disease (GvHD) or Sjögren's syndrome (SS). The study was conducted on 24 patients (48 eyes). AS was applied 6-10 times daily for 3 months together with regular artificial tear therapy. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0231473PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7173771PMC

Total external ophthalmoplegia and Sjögren's syndrome.

Strabismus 2020 03;28(1):34

Dr DY Patil University, Pune.

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http://dx.doi.org/10.1080/09273972.2019.1704802DOI Listing

Gut microbial dysbiosis in individuals with Sjögren's syndrome.

Microb Cell Fact 2020 Apr 15;19(1):90. Epub 2020 Apr 15.

Department of Surgery, University of Miami, Miami, FL, USA.

Background: Autoimmune diseases have been associated with changes in the gut microbiome. In this study, the gut microbiome was evaluated in individuals with dry eye and bacterial compositions were correlated to dry eye (DE) measures. We prospectively included 13 individuals with who met full criteria for Sjögren's (SDE) and 8 individuals with features of Sjögren's but who did not meet full criteria (NDE) for a total of 21 cases as compared to 21 healthy controls. Read More

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http://dx.doi.org/10.1186/s12934-020-01348-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7158097PMC

Diagnosing the Dry Eye Syndrome in modern society and among patients with glaucoma: a prospective study.

Rom J Ophthalmol 2020 Jan-Mar;64(1):35-42

Department of Ophthalmology and Optometry, "Nicolae Testemiţanu" State University of Medicine and Pharmacy, Chişinău, Republic of Moldova.

The dry eye syndrome (DES) is a disease of the ocular surface, which can become a social issue in our country, given the changes in lifestyle as a consequence of the economic and technological developments of the last decade. A current problem is the prevalence of DES in patients with glaucoma. The glaucoma treatment, especially the prolonged instillation of preservative-containing medicines, is an important factor in DES morbidity, especially in people aged over 40. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7141921PMC

[Importance of Transient Receptor Potential Channels of the Ocular Surface: Insights and Outlook - from Laboratory Research to Clinical Practice].

Klin Monbl Augenheilkd 2020 May 14;237(5):637-643. Epub 2020 Apr 14.

Klinik für Augenheilkunde, Charité - Universitätsmedizin Berlin, Campus Virchow-Klinik.

Optimal vision requires an ocular surface with vital epithelial coverage and a stable tear film. A multitude of endogenous and external factors may alter this delicate balance. Studies over the last decade have established that Ca is an important factor in the control of ocular surface epithelial function and has led to the identification of critical components. Read More

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http://dx.doi.org/10.1055/a-1120-8754DOI Listing

Childhood Rheumatic Diseases and COVID-19 Pandemic: An Intriguing Linkage and a New Horizon

Balkan Med J 2020 06 8;37(4):184-188. Epub 2020 Apr 8.

Department of Pediatric Rheumatology, İstanbul University-Cerrahpaşa Cerrahpaşa School of Medicine, İstanbul, Turkey

As it is known, we are all in a pandemic situation due to a novel coronavirus, officially named “Severe Acute Respiratory Syndrome Coronavirus 2” and the disease caused by the virus named “Coronavirus disease-2019”. The virus seems to has propensity to infect older male individuals with underlying disease. The clinical features were on a large scale that varies from being an asymptomatic carrier to acute respiratory distress syndrome and multiorgan dysfunction. Read More

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http://dx.doi.org/10.4274/balkanmedj.galenos.2020.2020.4.43DOI Listing

Ocular Clinical Signs and Diagnostic Tests Most Compatible With Keratoconjunctivitis Sicca: A Latent Class Approach.

Cornea 2020 Apr 2. Epub 2020 Apr 2.

Department of Ophthalmology, University of California San Francisco, San Francisco, California.

Purpose: To evaluate the ocular signs and tests for keratoconjunctivitis sicca (KCS) in the absence of a gold standard.

Methods: Cross-sectional study of participants from the Sjögren's International Collaborative Clinical Alliance (SICCA) registry. Participants had oral/ocular/rheumatologic examinations, blood/saliva samples collected, and salivary gland biopsy. Read More

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http://dx.doi.org/10.1097/ICO.0000000000002311DOI Listing

Schirmer Paper Noninvasive Microsampling for Direct Mass Spectrometry Analysis of Human Tears.

Anal Chem 2020 May 14;92(9):6207-6212. Epub 2020 Apr 14.

Institute of Mass Spectrometry and Atmospheric Environment, Guangdong Provincial Engineering Research Center for On-line Source Apportionment System of Air Pollution, Jinan University, Guangzhou 510632, China.

Rapid and sensitive detection of metabolites and chemical residues in human tears is highly beneficial for understanding eye health. In this study, Schirmer paper was used for noninvasive microsampling of human tears, and then paper spray mass spectrometry (PSMS) was performed for direct analysis of human tears. Schirmer PSMS was successfully used for rapid diagnosis of dry-eye syndrome by detecting the volume and metabolites of human tears. Read More

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http://dx.doi.org/10.1021/acs.analchem.9b05078DOI Listing

Analysis of ocular surface damage and visual impact in patients with primary and secondary Sjögren syndrome.

Rheumatol Int 2020 Apr 2. Epub 2020 Apr 2.

Tecnologico de Monterrey, School of Medicine and Health Sciences, Institute of Ophthalmology and Visual Sciences, Monterrey, Mexico.

The objective of this study is to review the ocular surface changes and complications of patients with Sjögren syndrome and assess their visual impact. A retrospective, cross-sectional, observational, and descriptive study of patients with Sjögren syndrome diagnosed according to the American-European Consensus Group criteria was designed. Data including age, gender, the reason for consultation, associated systemic disease, visual acuity, and ocular complications were recorded. Read More

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http://dx.doi.org/10.1007/s00296-020-04568-7DOI Listing

[Treatment of chronic blepharitis].

Vestn Oftalmol 2020 ;136(1):97-102

OOONPP 'LAZMA', 8 Tvardovskogo St., Moscow, Russian Federation, 123458.

The most effective method of treating chronic blepharitis - a disease with multifactorial pathogenesis requiring an individual approach - is a combination of remedial measures that addresses eyelids hygiene and includes medicated and device therapy. Read More

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http://dx.doi.org/10.17116/oftalma202013601197DOI Listing

Interactions of Perfluorohexyloctane With Polyethylene and Polypropylene Pharmaceutical Packaging Materials.

J Pharm Sci 2020 Mar 30. Epub 2020 Mar 30.

Biomedical Science, Faculty of Health and Society, Malmö University, SE-205 06 Malmö, Sweden; Biofilms - Research Center for Biointerfaces, Malmö University, SE-205 06 Malmö, Sweden. Electronic address:

Semifluorinated alkanes (SFAs) are aprotic solvents, which may be used as drug solvents for topical ocular applications, for instance, in dry eye syndrome. Their physical properties suggest that they might be prone to interaction with plastic materials, such as, polyethylene (PE) and polypropylene (PP), which are commonly used as packaging materials for pharmaceutical products. In this study, we investigate interactions of PE and PP with a liquid SFA perfluorohexyloctane (PFHO) using differential scanning calorimetry (DSC), thermogravimetric analysis (TGA) and cross-polarized light microscopy. Read More

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http://dx.doi.org/10.1016/j.xphs.2020.03.026DOI Listing