1,430,711 results match your criteria Drugs in R&D[Journal]


Vasoactive Agents for the Management of Variceal Bleeding: A Mixed Treatment Comparison Network Meta-analysis and Trial Sequential Analysis of Randomized Clinical Trials.

Drug Res (Stuttg) 2019 Feb 18. Epub 2019 Feb 18.

School of Oral Health, College of Medicine, Nursing and Health Sciences, Fiji National University, Suva, Fiji Islands.

Background: Vasoactives such as terlipressin, somatostatin, vasopressin, octreotide and nitrates are commonly used to treat variceal bleeding. The present study is a network meta-analysis comparing the efficacy and safety of the above vasoactive agents for treating variceal bleeding.

Methods: Electronic databases were searched for appropriate randomized clinical trials evaluating vasoactives in cirrhotic patients with variceal bleeding. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1055/a-0846-3071DOI Listing
February 2019

[Guidelines of the German Respiratory Society for Diagnosis and Treatment of Adults Suffering from Acute, Subacute and Chronic Cough].

Pneumologie 2019 Feb 18. Epub 2019 Feb 18.

Facharztforum Fürth.

The present 2019 S2k consensus guideline of the German Respiratory Society was written - in contrast to the predecessor more general S3 guidelines from 2004 and 2010 - for pneumologists, since 2014 the German College of General Practitioners and Family Physicians (DEGAM) published his own cough guidelines.The guideline contains 48 recommendations agreed by consensus and 16 statements, which are explained in the background text in the following nine chapters: epidemiology, physiology, classification, acute, subacute or chronic cough, diagnostics and therapy; an extra chapter was dedicated to chronic idiopathic cough. Further emphasis of the guideline is the physiology of cough in anticipation of the introduction of new drugs, as well as detailed treatises on cough triggered by affections in the upper respiratory tract or by gastroesophageal reflux. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1055/a-0808-7409DOI Listing
February 2019

Revealing quinquennial anticancer journey of morpholine: A SAR based review.

Eur J Med Chem 2019 Feb 8;167:324-356. Epub 2019 Feb 8.

Drug Design & Medicinal Chemistry Lab, Department of Pharmaceutical Chemistry, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi, 110062, India. Electronic address:

Morpholine, a six-membered heterocycle containing one nitrogen and one oxygen atom, is a moiety of great significance. It forms an important intermediate in many industrial and organic syntheses. Morpholine containing drugs are of high therapeutic value. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ejmech.2019.02.015DOI Listing
February 2019

Another look at phenolic compounds in cancer therapy the effect of polyphenols on ubiquitin-proteasome system.

Eur J Med Chem 2019 Jan 30;167:291-311. Epub 2019 Jan 30.

Department of Food Analysis, Institute of Agricultural and Food Biotechnology, Rakowiecka 36, 02-532, Warsaw, Poland. Electronic address:

Inhibitors of the ubiquitin-proteasome system (UPS) have been the object of research interests for many years because of their potential as anti-cancer agents. Research in this field is aimed at improving the specificity and safety of known proteasome inhibitors. Unfortunately, in vitro conditions do not reflect the processes taking place in the human body. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ejmech.2019.01.044DOI Listing
January 2019

Activation of ATP-sensitive K-channel promotes the anticonvulsant properties of cannabinoid receptor agonist through mitochondrial ATP level reduction.

Epilepsy Behav 2019 Feb 15;93:1-6. Epub 2019 Feb 15.

Brain and Spinal Cord Injury Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran; Experimental Medicine Research Center, Tehran University of Medical Sciences, Tehran, Iran. Electronic address:

Cannabinoid receptor (CBR) agonist could act as a protective agent against seizure susceptibility in animal models of epilepsy. Studies have shown that potassium channels could play a key role in ameliorating neuronal excitability. In this study, we attempted to evaluate how CBRs and Adenosine Tri-Phosphate (ATP)-sensitive potassium channels collaborate to affect seizure susceptibility by changing the clonic seizure threshold (CST). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.yebeh.2019.01.025DOI Listing
February 2019

KiSS1 in regulation of metastasis and response to antitumor drugs.

Drug Resist Updat 2019 Feb 11;42:12-21. Epub 2019 Feb 11.

Molecular Pharmacology Unit, Department of Applied Research and Technological Development, Fondazione IRCCS Istituto Nazionale dei Tumori, Via Amadeo 42/via Venezian 1, 20133 Milan, Italy. Electronic address:

Metastatic dissemination of tumor cells represents a major obstacle towards cancer cure. Tumor cells with metastatic capacity are often resistant to chemotherapy. Experimental efforts revealed that the metastatic cascade is a complex process that involves multiple positive and negative regulators. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.drup.2019.02.001DOI Listing
February 2019

Tumor targeting peptides: novel therapeutic strategies in glioblastoma.

Authors:
Drazen Raucher

Curr Opin Pharmacol 2019 Feb 15;47:14-19. Epub 2019 Feb 15.

Department of Cell and Molecular Biology, University of Mississippi Medical Center, Jackson, MS, United States. Electronic address:

Peptides are a promising new therapeutic approach for glioblastoma with potential for more effective targeting and fewer devastating side effects compared to conventional cancer therapies. With the specificity to target receptors which are uniquely or overexpressed on cancer cells as well as accurately targeting dysregulated signaling pathways, peptides demonstrate a high potential for the treatment of even the most aggressive cancers. By binding to these targets, peptides can be used to deliver drugs, serve as antagonists to various ligands, or, given some inherent anticancer activity, provide additional treatment options alone or in combination therapy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.coph.2019.01.006DOI Listing
February 2019

Inclusion complex of saikosaponin-d with hydroxypropyl-β-cyclodextrin: Improved physicochemical properties and anti-skin cancer activity.

Phytomedicine 2018 Nov 8;57:174-182. Epub 2018 Nov 8.

Department of Fragrance and Cosmetic Science, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan; Institute of Biomedical Sciences, National Sun Yat-Sen University, Kaohsiung, Taiwan. Electronic address:

Background: Saikosaponin-d (SSD) is a triterpene saponin isolated from Bupleurum plants. It has been shown to exhibit antioxidant, anti-inflammatory, and anticancer activities. However, its biomedical applications are limited by its poor water solubility. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.phymed.2018.11.012DOI Listing
November 2018

Polyoxomolybdates as α-glucosidase inhibitors: Kinetic and molecular modeling studies.

J Inorg Biochem 2019 Feb 8;193:173-179. Epub 2019 Feb 8.

College of Food and Biological Engineering, Jimei University, Xiamen 361021, PR China.

Noninsulin dependent diabetes mellitus is a serious global disease that is treated by inhibiting α-glucosidase to reduce the glucose content in the blood. Several incompletely satisfactory therapeutic drugs are already on the market. In this report, we showed that polyoxomolybdates based on Keggin-type architecture are promising candidates. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jinorgbio.2019.02.001DOI Listing
February 2019

Performance evaluation of the Hologic Aptima HCV Quant Dx assay for detection of HCV RNA from dried blood spots.

J Clin Virol 2019 Jan 25;112:40-44. Epub 2019 Jan 25.

The Kirby Institute, UNSW Sydney, Sydney, New South Wales, Australia.

Background: The availability of effective direct-acting antiviral therapy for hepatitis C virus (HCV) has led to a need for simplified diagnostic pathways. Barriers to treatment uptake, specifically in people who inject drugs and in remote and resource limited settings, may be overcome by utilizing novel collection methods, such as dried blood spots (DBS). However, there are currently no registered assays for HCV RNA testing from DBS samples. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jcv.2019.01.010DOI Listing
January 2019

Role of esterase mediated hydrolysis of simvastatin in human and rat blood and its impact on pharmacokinetic profiles of simvastatin and its active metabolite in rat.

J Pharm Biomed Anal 2019 Feb 6;168:13-22. Epub 2019 Feb 6.

School of Pharmacy, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong Special Administrative Region. Electronic address:

Simvastatin is known as a pro-drug, which could be hydrolyzed by esterases to its active form, simvastatin acid. Although pharmacokinetics of simvastatin and simvastatin acid have been widely studied, hydrolysis of simvastatin to simvastatin acid during blood sampling and plasma preparation has been overlooked in the previous studies, leading to underestimation of simvastatin concentration and overestimation of simvastatin acid concentration in plasma. Since both efficacy and adverse drug reaction of simvastatin are highly dependent on simvastatin and simvastatin acid concentrations in vivo, accurate assessment of the two compounds are critical in their pharmacokinetic and pharmacodynamic studies. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jpba.2019.02.004DOI Listing
February 2019

Clinically significant drug-drug interactions involving medications used for symptom control in patients with advanced malignant disease. A systematic review.

J Pain Symptom Manage 2019 Feb 15. Epub 2019 Feb 15.

Regional Centre of Excellence for Palliative Care, Western Norway, Haukeland University Hospital, Bergen, Norway; Department of Clinical Medicine K1, University of Bergen, Bergen, Norway.

Context: Most patients with advanced malignant disease need to take several drugs to control symptoms. This treatment raises risks of serious adverse effects and drug-drug interactions (DDIs).

Objectives: To identify studies reporting clinically significant DDIs involving medications used for symptom control, other than opioids used for pain management, in adult patients with advanced malignant disease. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jpainsymman.2019.02.006DOI Listing
February 2019

Local inhibition of uptake transporters augments stress-induced increases in serotonin in the rat central amygdala.

Neurosci Lett 2019 Feb 15. Epub 2019 Feb 15.

Department of Biology and Neuroscience Group, University of South Dakota, Vermillion, SD 57069, USA. Electronic address:

Organic cation transporter 3 (OCT3) is a corticosterone-sensitive, low-affinity, high-capacity transporter. This transporter functions, in part, to clear monoamines, including serotonin (5-HT), from the extracellular space. The central nucleus of the amygdala (CeA) is an important structure controlling fear- and anxiety-related behaviors. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neulet.2019.02.022DOI Listing
February 2019

Biosynthesis of silver nanoparticle using extract of Zea mays (corn flour) and investigation of its cytotoxicity effect and radical scavenging potential.

J Photochem Photobiol B 2019 Jan 17;193:1-7. Epub 2019 Jan 17.

Research Institute of Biotechnology & Medical Converged Science, Dongguk University-Seoul, Ilsandong-gu, Gyeonggi-do 10326, Republic of Korea. Electronic address:

Silver nanoparticles (AgNPs) possesses a number of exceptional pharmaceutical properties and applications as compared with other types of metallic nanoparticles. Currently, AgNPs was biosynthesized using an aqueous extract of Zea mays L. (corn flour) powder. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jphotobiol.2019.01.008DOI Listing
January 2019

HLA-A*32:01 is strongly associated with vancomycin-induced drug reaction with eosinophilia and systemic symptoms.

J Allergy Clin Immunol 2019 Feb 15. Epub 2019 Feb 15.

Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, USA, 37232; Institute for Immunology and Infectious Diseases, Murdoch University, Murdoch, Western Australia, AUS, 6150; Division of Infectious Diseases, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA, 37232; Department of Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee, USA, 37232. Electronic address:

Background: Vancomycin is a prevalent cause of the severe hypersensitivity syndrome drug reaction with eosinophilia and systemic symptoms (DRESS) which leads to significant morbidity and mortality and commonly occurs in the setting of combination antibiotic therapy which impacts future treatment choices. Variations in human leukocyte antigen (HLA) class I in particular have been associated with serious T-cell mediated adverse drug reactions which has led to preventive screening strategies for some drugs.

Objective: To determine if variation in the HLA region is associated with vancomycin-induced DRESS. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00916749193021
Publisher Site
http://dx.doi.org/10.1016/j.jaci.2019.01.045DOI Listing
February 2019
3 Reads

Many ways to resistance: How melanoma cells evade targeted therapies.

Biochim Biophys Acta Rev Cancer 2019 Feb 15. Epub 2019 Feb 15.

Life Sciences Research Unit, University of Luxembourg, 6, avenue du Swing, L-4367 Belvaux, Luxembourg. Electronic address:

Melanoma is an aggressive malignancy originating from pigment-producing melanocytes. The development of targeted therapies (MAPK pathway inhibitors) and immunotherapies (immune checkpoint inhibitors) led to a substantial improvement in overall survival of patients. However, the long-term efficacy of such treatments is limited by side effects, lack of clinical effects and the rapidly emerging resistance to treatment. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbcan.2019.02.002DOI Listing
February 2019

Simultaneous Analysis of Dissolution and Permeation Profiles of Nano- and Microsized Formulations of Indomethacin Using the In Vitro Dissolution Absorption System 2 (IDAS2).

J Pharm Sci 2019 Feb 15. Epub 2019 Feb 15.

Absorption Systems LP, Exton, Pennsylvania 19341, U.S.A.

The in vitro dissolution absorption system (IDAS2), a recent invention comprised of a conventional dissolution vessel containing two permeation chambers with Caco-2 cell monolayers mounted with their apical side facing the dissolution media, permits simultaneous measurement of dissolution and permeation of drugs from intact clinical dosage forms. The objectives of this study were 1) to assess the utility of IDAS2 in the determination of the effect of particle size on in vitro performance of indomethacin and 2) to find out whether the behavior in IDAS2 of two indomethacin products differing in particle size is correlated with their in vivo behavior. Indomethacin dissolution and permeation across Caco-2 cell monolayers were simultaneously measured in IDAS2; the dissolution and permeation profiles were simultaneously modeled using a simple two-compartment model. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.xphs.2019.01.032DOI Listing
February 2019

Glycogen synthase kinase-3 inhibitor as a multi-targeting anti-rheumatoid drug.

Biochem Pharmacol 2019 Feb 15. Epub 2019 Feb 15.

Department of Pharmacology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan. Electronic address:

Rheumatoid arthritis (RA) is a chronic inflammatory joint disease that causes swelling, bone erosion, and joint disorder. Patients with RA therefore suffer from pain and physiological disability, and have a decreased quality of life. During the progression of RA, many different types of cells and inflammatory factors influence each other with an important role. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bcp.2019.02.020DOI Listing
February 2019

[Transition of adolescents with attention deficit/hyperactivity disorder. Implications for treatment of adults].

Medicina (B Aires) 2019 ;79 Suppl 1:72-76

Centro de Salud de Catarroja, Valencia, España.

Attention deficit hyperactivity disorder (ADHD) is a chronic, complex and multifactorial neurodevelopmental disorder associated with high rates of concurrent psychiatric disorders, along with problems and complications on different areas of individual functioning. ADHD is not exclusively a childhood disorder, 40-60% persisting into adulthood with an estimated prevalence of 2.5-5%. Read More

View Article

Download full-text PDF

Source
January 2019

[Influence of phosphogliv® hepatoprotector on phospholipid spectrum of peripheral blood mononuclears in patients with tuberculosis of lungs.]

Klin Lab Diagn 2018 ;63(11):686-690

Federal State Budgetary Educational Institution of Higher Education "Tver State Medical University" of the Ministry of Healthcare of the Russian Federation, 170100, Tver, Russia.

The administration of the "Phosphogliv®" hepatoprotector in the comprehensive treatment of patients with pulmonary tuberculosis will allow determining its effect on the lipid composition of membranes of mononuclear cells under conditions of etiotropic chemotherapy according to 1 standard regimen. The determination of the ratios of the most important classes of phospholipids in membranes of peripheral blood mononuclear cells will give an idea of the structural-functional state violation of the most important representatives of the cellular immunity in patients with tuberculosis prior to treatment, against the backdrop of the intensive phase of the main course of chemotherapy as well as the change in these indices when the "Phosphogliv®" drug is administered in the comprehensive treatment therapy. The study included 356 patients with pulmonary tuberculosis of young and middle age, out of which 308 patients received etiotropic chemotherapy without the administration of phosphogliv, and 48 patients receiving comprehensive treatment used a combined scheme of oral-parenteral administration of phosphogliv. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.18821/0869-2084-2018-63-11-686-690DOI Listing
January 2018

Lutidine-Based Chiral Pincer Mn Catalysts for Enantioselective Hydrogenation of Ketones.

Angew Chem Int Ed Engl 2019 Feb 18. Epub 2019 Feb 18.

Shanghai Institute of Organic Chemistry, CHINA.

A series of Mn(I) complexes containing lutidine-based chiral pincer ligands with modular and tunable structures has been developed. The complex features unprecedentedly high activity (up to 9800 TON), broad substrate scope (81 examples), good functional group tolerance, and excellent enantioselectivity (85~98% ee) in the hydrogenation of various ketones, which are rare in earth-abundant metal catalyzed hydrogenation. The utilities of the protocol have been demonstrated in the asymmetric synthesis of a variety of key intermediates of chiral drugs. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/anie.201814751
Publisher Site
http://dx.doi.org/10.1002/anie.201814751DOI Listing
February 2019
1 Read

Possible association of HMOX1 and NQO1 polymorphisms with anti-tuberculosis drug-induced liver injury: A matched case-control study.

J Clin Pharm Ther 2019 Feb 18. Epub 2019 Feb 18.

Department of Epidemiology, School of Public Health, Nanjing Medical University, Nanjing, China.

What Is Known And Objective: Reactive metabolites from anti-tuberculosis (anti-TB) drugs can result in abnormal accumulation of reactive oxygen species (ROS), which plays an important role in anti-TB drug-induced liver injury (ATLI). Liver cells could keep the production of ROS in balance by antioxidant activities. The heme oxygenase 1, encoded by the HMOX1 gene and NADH:quinone oxidoreductase 1, encoded by the NQO1 gene are crucial mediators of cellular defense against ROS. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jcpt.12818DOI Listing
February 2019

Regulating consumer use of transcranial direct current stimulation devices.

Med J Aust 2018 Jul;209(1):8-9

Monash Alfred Psychiatry Research Centre, Alfred Health, Melbourne, VIC.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5694/mja17.00778DOI Listing

Actual Anti-TNF Trough Levels Relate to Serum IL-10 in Drug-Responding Patients With Crohn's Disease.

Inflamm Bowel Dis 2019 Feb 19. Epub 2019 Feb 19.

CIBERehd, Instituto de Salud Carlos III, Madrid, Spain.

Background: Patients with Crohn's disease (CD) responding to anti-tumor necrosis factor (anti-TNF) show great variability in serum drug levels, even within the therapeutic range. We aimed at exploring the role of inflammatory, genetic, and bacterial variables in relation to anti-TNF through levels in CD patients.

Methods: Consecutive CD patients receiving stable doses of infliximab or adalimumab were included. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/ibd/izz012DOI Listing
February 2019

Antiepileptic Drug Use Is Associated with an Increased Risk of Pneumonia Among Community-Dwelling Persons with Alzheimer's Disease-Matched Cohort Study.

J Alzheimers Dis 2019 Feb 11. Epub 2019 Feb 11.

School of Pharmacy, University of Eastern Finland, Kuopio, Finland.

Background: Antiepileptic drugs (AEDs) have sedative properties which may lead to an increased risk of pneumonia.

Objectives: To investigate whether incident AED use is associated with an increased risk of pneumonia among community-dwelling persons with Alzheimer's disease (AD). In addition, we determined the risk according to duration of AED use and specific AEDs. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3233/JAD-180912DOI Listing
February 2019

The Alz-tau Biomarker for Alzheimer's Disease: Study in a Caucasian Population.

J Alzheimers Dis 2019 Feb 11. Epub 2019 Feb 11.

Laboratory of Neuroscience, International Center for Biomedicine (ICC) and Faculty of Sciences, University of Chile, Santiago, Chile.

The establishment of a molecular biomarker for early detection of Alzheimer's disease (AD) is critical for diagnosis and follow up of patients, and as a quantitative parameter in the evaluation of potential new drugs to control AD. A list of blood biomarkers has been reported but none has been validated for the Alzheimer's clinic. The changes in hyperphosphorylated tau and amyloid peptide in the cerebrospinal fluid is currently used as a tool in the clinics and for research purposes, but this method is highly invasive. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3233/JAD-180637DOI Listing
February 2019

The relevance of persisters in tuberculosis drug discovery.

Microbiology 2019 Feb 18. Epub 2019 Feb 18.

TB Discovery Research, Infectious Disease Research Institute, 1616 Eastlake Ave. E, Suite 400, Seattle, WA 98102, USA.

Bacterial persisters are a subpopulation of cells that exhibit phenotypic resistance during exposure to a lethal dose of antibiotics. They are difficult to target and thought to contribute to the long treatment duration required for tuberculosis. Understanding the molecular and cellular biology of persisters is critical to finding new tuberculosis drugs that shorten treatment. Read More

View Article

Download full-text PDF

Source
http://www.microbiologyresearch.org/content/journal/micro/10
Publisher Site
http://dx.doi.org/10.1099/mic.0.000760DOI Listing
February 2019
1 Read

Why have transgenic rodent models failed to successfully mimic Alzheimer's disease. How can we develop effective drugs without them?

Expert Opin Drug Discov 2019 Feb 18:1-4. Epub 2019 Feb 18.

b CiberNed: Centro de Investigación en Red, enfermedades Neurodegenerativas , Instituto de Salud Carlos III , Madrid , Spain.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/17460441.2019.1581169DOI Listing
February 2019

New synthetic opioid cyclopropylfentanyl together with other novel synthetic opioids in respiratory insufficient comatose patients detected by toxicological analysis.

Clin Toxicol (Phila) 2019 Feb 18:1-7. Epub 2019 Feb 18.

e Forensic Toxicological Laboratory , University Medical Center Göttingen, Georg-August-University , Göttingen , Germany.

Introduction: Fentanyl derivatives like cyclopropylfentanyl have recently appeared on the recreational drug market. Cyclopropylfentanyl is probably a highly potent opioid, but human toxicological data are not available so far. Similar to other fentanyl derivatives the most serious acute health risk due to the use of cyclopropylfentanyl is likely to be respiratory depression. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/15563650.2018.1554187DOI Listing
February 2019

Therapy of acute myeloid leukemia: therapeutic targeting of tyrosine kinases.

Expert Opin Investig Drugs 2019 Feb 18. Epub 2019 Feb 18.

a Penn State Hershey Medical Center , 500 University Drive, Hershey , PA , 17033.

Introduction: Tyrosine kinases (TKs) drive cell survival and proliferation in many normal and malignant cell types. TKs are frequently mutated in acute myeloid leukemia (AML) and hence are increasingly targeted. The management of AML has dramatically improved because of TKI-targeted treatment. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/13543784.2019.1584610DOI Listing
February 2019

Total Synthesis of Aaptamine, Demethyloxyaaptamine, and Their 3-Alkylamino Derivatives.

Org Lett 2019 Feb 18. Epub 2019 Feb 18.

Research Center for Marine Drugs, State Key Laboratory of Oncogene and Related Genes, Department of Pharmacy, Ren Ji Hospital, School of Medicine , Shanghai Jiao Tong University , Shanghai 200127 , China.

A simple and efficient synthetic route for preparing the benzonaphthyridine framework is reported. Only seven steps are needed for the assembly of 3-alkylamino aaptamine from inexpensive isoquinoline 6 by this route with about 20% overall yield. The two key steps are a novel palladium-catalyzed reductive cyclization with Mo(CO) as reductant to form aaptamine and demethyloxyaaptamine and a hydrogen-bond-mediated oxidative alkylamination to account for the complete regioselectivity. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.orglett.9b00183DOI Listing
February 2019

Incorporation of a rhodamine B conjugated polymer for nanoparticle trafficking both in vitro and in vivo.

Biomater Sci 2019 Feb 18. Epub 2019 Feb 18.

School of Biomedical Sciences and Engineering, South China University of Technology, Guangzhou International Campus, Guangzhou 510006, P. R. China. and Institutes for Life Sciences and School of Medicine, South China University of Technology, Guangzhou, Guangdong 510006, China. and Guangdong Key Laboratory of Nanomedicine, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, PR China and Research Institute for Food Nutrition and Human Health, South China University of Technology, Guangzhou 510641, China and Guangzhou Regenerative Medicine and Health Guangdong Laboratory, Guangzhou 510005, China.

Polymeric nanoparticles as drug delivery systems have the potential to improve the therapeutic efficacy and reduce the toxicity of chemotherapeutic drugs by enhancing the drug selectivity in vivo. The efficacy is directly dependent on the polymeric nanoparticles' in vivo fate. Therefore, it is very important to develop a method to stably label the polymeric nanoparticles for detecting the in vivo fate. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1039/c9bm00032aDOI Listing
February 2019

Fluctuation correlations as major determinants of structure- and dynamics-driven allosteric effects.

Phys Chem Chem Phys 2019 Feb 18. Epub 2019 Feb 18.

College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China. and Center for Quantitative Biology, State Key Laboratory for Structural Chemistry of Unstable and Stable Species, and BNLMS, Peking University, Beijing 100871, China.

Allosteric control is essential for regulating biological functions whereby stimuli such as ligand binding at one site on a protein cause a response at a distant functional site. Correlations between different sites in proteins have been used widely in identifying allosteric sites and pathways, and in designing allosteric drugs. However, the deterministic connection between correlations and allostery remains unsolved, especially considering that there are various types of correlations. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1039/c8cp07859aDOI Listing
February 2019

Multimarker Panels in Diabetic Kidney Disease: The Way to Improved Clinical Trial Design and Clinical Practice?

Kidney Int Rep 2019 Feb 18;4(2):212-221. Epub 2018 Dec 18.

Department of Internal Medicine IV (Nephrology and Hypertension), Medical University Innsbruck, Innsbruck, Austria.

Diabetic kidney disease (DKD) is a complex and multifactorial disorder associated with deregulations in a large number of different biological pathways on the molecular level. Using the 2 established biomarkers, estimated glomerular filtration rate (eGFR) and albuminuria will not allow allocating patients to tailored therapy. Molecular multimarker panels as sensors for the deregulation of the various disease mechanisms combined with a better understanding of how investigational as well as approved drugs interfere with these disease processes forms the basis for platform trials in DKD. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ekir.2018.12.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365367PMC
February 2019

Helminthiases; prevalence, transmission, host-parasite interactions, resistance to common synthetic drugs and treatment.

Heliyon 2019 Jan 31;5(1):e01161. Epub 2019 Jan 31.

Medicinal Plants and Economic Development (MPED) Research Centre, Department of Botany, University of Fort Hare, Alice, 5700, South Africa.

The morbidity caused by parasite worms on susceptible hosts is of great concern and studies were carried out to explain the mechanism of infection, prevalence, host-parasite interaction and resistance of the parasite to treatment. This review elucidates the prevalence of parasitic worm infections; which is on the increases with the increase in the world population, global warming, poor standard of living particularly in troubled regions and developing nations. The neglect of the disease coupled with the resistance of these parasites to the few available drugs becomes a huge challenge that influences global disease burden. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.heliyon.2019.e01161DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357211PMC
January 2019

New Treatment Option for Autoimmune Enteropathy: A Rare Case of Intractable Diarrhea Treated with Vedolizumab.

ACG Case Rep J 2018 5;5:e92. Epub 2018 Dec 5.

Department of Digestive Diseases, Emory University School of Medicine, Atlanta, GA.

Autoimmune enteropathy is an uncommon cause of chronic diarrhea rarely seen in adults. The disease is secondary to an autoimmune process in the gut that leads to villous blunting and subsequent watery diarrhea, abdominal pain, and severe weight loss. The disease has only been described in 37 adults prior to our case, and variable treatment success has been documented with steroids, immunomodulators, and TNF-α inhibitors. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.14309/crj.2018.92DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358579PMC
December 2018

Expression and serological application of recombinant epitope-repeat protein carrying an immunodominant epitope of Newcastle disease virus nucleoprotein.

Clin Exp Vaccine Res 2019 Jan 31;8(1):27-34. Epub 2019 Jan 31.

Planning and Coordination Division, Animal and Plant Quarantine Agency, Gimcheon, Korea.

Purpose: The aim of the present study was to develop a serodiagnostic test for differentiation infected from vaccinated animal (DIVA) strategy accompanying the marker vaccine lacking an immunodominant epitope (IDE) of nucleoprotein of Newcastle disease virus (NDV).

Materials And Methods: Recombinant epitope-repeat protein (rERP) gene encoding eight repeats of the IDE sequence (ETQFLDLMRAVANSMR) by tetra-glycine linker was synthesized. Recombinant baculovirus carrying the rERP gene was generated to express the rERP in insect cells. Read More

View Article

Download full-text PDF

Source
https://synapse.koreamed.org/DOIx.php?id=10.7774/cevr.2019.8
Publisher Site
http://dx.doi.org/10.7774/cevr.2019.8.1.27DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369128PMC
January 2019
1 Read

Dihydropyrimidine dehydrogenase deficiency as a cause of fatal 5-Fluorouracil toxicity.

Autops Case Rep 2018 Oct-Dec;8(4):e2018049. Epub 2018 Nov 30.

University of Chicago Medicine, Department of Pathology. Chicago, IL, USA.

5-Fluorouracil (5-FU), in combination with other cytotoxic drugs, is commonly used to treat a variety of cancers. Dihydropyrimidine dehydrogenase (DPD) catalyzes the first catabolic step of the 5-FU degradation pathway, converting 80% of 5-FU to its inactive metabolite. Approximately 0. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4322/acr.2018.049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360833PMC
November 2018

Large desmoid tumors in familial adenomatous polyposis: a successful outcome.

Autops Case Rep 2018 Oct-Dec;8(4):e2018045. Epub 2018 Sep 26.

Centro Hospitalar de São João, Department of Surgery. Porto, Portugal.

Desmoid tumors develop from connective tissue, fasciae, and aponeuroses, and may occur in the context of familial adenomatous polyposis or may arise sporadically; also, they may be extra-abdominal, intra-abdominal, or located in the abdominal wall. These benign tumors have a great aggressiveness with a high rate of local recurrence. Familial adenomatous polyposis is an inherited condition with autosomal dominant transmission, and is characterized by the development of multiple colonic and rectal adenomatous polyps, as well as desmoid tumors. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4322/acr.2018.045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360820PMC
September 2018

Clinical Profile and Comparison of Causality Assessment Tools in Cutaneous Adverse Drug Reactions.

Indian Dermatol Online J 2019 Jan-Feb;10(1):27-33

Department of Dermatology, Venereology and Leprology, R.N.T Medical College, Udaipur, Rajasthan, India.

Background: Cutaneous adverse drug reactions (CADRs) are probably the most frequent of all manifestations of drug sensitivity. As a considerable number of new drugs are periodically introduced into the market, the incidence of CADR is likely to increase. The pattern of CADR and the causative drugs is likely to change accordingly. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4103/idoj.IDOJ_207_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362752PMC
February 2019

HIV, HBV and HCV in people who inject drugs and are placed on methadone maintenance therapy, Yangon, Myanmar.

Public Health Action 2018 Dec;8(4):202-210

National Drug Abuse Prevention and Control Programme, Ministry of Health and Sports, Nay Pyi Taw, Myanmar.

Two drug treatment centres (DTCs) for people who inject drugs (PWID) and are enrolled in methadone maintenance therapy (MMT), Yangon, Myanmar. To determine, in PWID enrolled for MMT from 2015 to 2017, 1) testing uptake and results for human immunodeficiency virus (HIV), hepatitis B virus (HBV) and hepatitis C virus (HCV); 2) risk factors for infection; and 3) retention in care and risk factors for loss to follow-up (LTFU). Cohort study using secondary data. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5588/pha.18.0050DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361496PMC
December 2018

Public health interventions for reducing HIV, hepatitis B and hepatitis C infections in people who inject drugs.

Authors:
D Richardson C Bell

Public Health Action 2018 Dec;8(4):153

Adelaide Sexual Health Centre, Adelaide, South Australia, Australia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5588/pha.18.0093-edDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361494PMC
December 2018

Combination therapy with androgen deprivation for hormone sensitive prostate cancer: A new frontier.

Asian J Urol 2019 Jan 15;6(1):57-64. Epub 2018 Sep 15.

Department of Urology, University of Wisconsin-Madison, Madison, WI, USA.

Androgen deprivation therapy (ADT) has been the standard of care for the last 75 years in metastatic hormone sensitive prostate cancer (PCa). However, this approach is rarely curative. Recent clinical trials have demonstrated that ADT combined with other agents, notably docetaxel and abiraterone, lead to improved survival. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ajur.2018.09.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363606PMC
January 2019

Current strategies for targeting the activity of androgen receptor variants.

Asian J Urol 2019 Jan 29;6(1):42-49. Epub 2018 Sep 29.

Department of Urology, University of California, Davis, Sacramento, CA, USA.

Current therapies for advanced prostate cancer, such as enzalutamide and abiraterone, focus on inhibiting androgen receptor (AR) activity and reducing downstream signaling pathways to inhibit tumor growth. Unfortunately, cancer cells are very adaptable and, over time, these cells develop mechanisms by which they can circumvent therapeutics. One of the many mechanisms that have been discovered is the generation of AR variants. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ajur.2018.07.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363599PMC
January 2019

Nanoscale Bacteria-Enabled Autonomous Drug Delivery System (NanoBEADS) Enhances Intratumoral Transport of Nanomedicine.

Adv Sci (Weinh) 2019 Feb 5;6(3):1801309. Epub 2018 Dec 5.

Department of Mechanical Engineering Virginia Tech Blacksburg VA 24061 USA.

Cancer drug delivery remains a formidable challenge due to systemic toxicity and inadequate extravascular transport of nanotherapeutics to cells distal from blood vessels. It is hypothesized that, in absence of an external driving force, the serovar Typhimurium could be exploited for autonomous targeted delivery of nanotherapeutics to currently unreachable sites. To test the hypothesis, a nanoscale bacteria-enabled autonomous drug delivery system (NanoBEADS) is developed in which the functional capabilities of the tumor-targeting . Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/advs.201801309DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364498PMC
February 2019

CAR-T immunotherapy: how will it change treatment for acute lymphoblastic leukemia and beyond?

Expert Opin Orphan Drugs 2018 8;6(10):563-566. Epub 2018 Oct 8.

Department of Pediatrics and Carbone Comprehensive Cancer Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.

Introduction: The recent approval of CD19 chimeric antigen receptor (CAR) T cells for refractory or second relapse of B cell acute lymphoblastic leukemia (B-ALL) has led to a paradigm shift. Besides being an alternative to chemotherapy and antibody-based approaches, CAR-T cells have become the first successful example of "personalized medicine."

Areas Covered: In clinical trials, tisagenlecleucel demonstrated higher response rates than prior therapies, and led to durable remissions lasting up to years for some children. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/21678707.2018.1529562DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6375487PMC
October 2018

Comparing the Efficacy of Intralesional Triamcinolone Acetonide With Verapamil in Treatment of Keloids: A Randomized Controlled Trial.

Dermatol Pract Concept 2019 Jan 31;9(1):4-9. Epub 2019 Jan 31.

Molecular Dermatology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

Background: Keloid management remains a challenging clinical problem despite numerous therapies reported until now. The efficacy of corticosteroids in the treatment of keloids has been well established. The most commonly used corticosteroid is intralesional triamcinolone. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5826/dpc.0901a02DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368080PMC
January 2019

Arthroscopic Iliopsoas Fractional Lengthening.

JBJS Essent Surg Tech 2018 Dec 28;8(4):e30. Epub 2018 Nov 28.

American Hip Institute, Westmont, Illinois.

Background: Iliopsoas fractional lengthening (IFL) is performed on patients with symptomatic internal snapping. This condition is defined as painful and sometimes audible snapping of the iliopsoas (IP) tendon over the femoral head or iliopectineal line. Arthroscopic IFL is performed if the snapping is unresponsive to conservative treatment. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2106/JBJS.ST.18.00020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358333PMC
December 2018
  • Page 1 of 28615