14,861 results match your criteria Drugs and Chemicals

Structural and Functional Validation of a Full-Thickness Self-Assembled Skin Equivalent for Disease Modeling.

Pharmaceutics 2022 Jun 7;14(6). Epub 2022 Jun 7.

Department of Dermatology, CHA Bundang Medical Center, CHA University School of Medicine, Seongnam 13497, Korea.

Recently, various types of in vitro-reconstructed 3D skin models have been developed for drug testing and disease modeling. Herein, we structurally and functionally validated a self-assembled reconstructed skin equivalent (RSE) and developed an IL-17a-induced in vitro psoriasis-like model using a self-assembled RSE. The tissue engineering approach was used to construct the self-assembled RSE. Read More

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Multidrug Resistance of Cancer Cells and the Vital Role of P-Glycoprotein.

Life (Basel) 2022 Jun 15;12(6). Epub 2022 Jun 15.

Faculty of Medicine and Pharmacy, University of Oradea, P-ta 1 Decembrie 10, 410087 Oradea, Romania.

P-glycoprotein (P-gp) is a major factor in the multidrug resistance phenotype in cancer cells. P-gp is a protein that regulates the ATP-dependent efflux of a wide range of anticancer medicines and confers resistance. Due to its wide specificity, several attempts have been made to block the action of P-gp to restore the efficacy of anticancer drugs. Read More

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Phytochemical and Potential Properties of Seaweeds and Their Recent Applications: A Review.

Mar Drugs 2022 May 24;20(6). Epub 2022 May 24.

Animal and Fish Production Department, College of Agricultural and Food Sciences, King Faisal University, Al-Ahsa 31982, Saudi Arabia.

Since ancient times, seaweeds have been employed as source of highly bioactive secondary metabolites that could act as key medicinal components. Furthermore, research into the biological activity of certain seaweed compounds has progressed significantly, with an emphasis on their composition and application for human and animal nutrition. Seaweeds have many uses: they are consumed as fodder, and have been used in medicines, cosmetics, energy, fertilizers, and industrial agar and alginate biosynthesis. Read More

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A new green approach for the reduction of consumed solvents and simultaneous quality control analysis of several pharmaceuticals using a fast and economic RP-HPLC method; a case study for a mixture of piracetam, ketoprofen and omeprazole drugs.

RSC Adv 2022 May 1;12(25):16301-16309. Epub 2022 Jun 1.

Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Beni-Suef University Alshaheed Shehata Ahmad Hegazy St. 62514 Beni-Suef Egypt

One of the main aims of green analytical chemistry (GAC) is the reduction of solvents and chemicals consumed. Recycling the mobile phase in chromatographic techniques provides an efficient way to implement GAC principles. However, this is not an easy job, particularly in the case of the gradient mode. Read More

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Designing of potent anti-diabetic molecules by targeting SIK2 using computational approaches.

Mol Divers 2022 Jun 21. Epub 2022 Jun 21.

Structural Biology and Bio-Computing Laboratory, Department of Bioinformatics, Alagappa University, Science Block, Karaikudi, Tamil Nadu, 630004, India.

Diabetes mellitus (DM) is one of the major health problems worldwide. WHO have estimated that 439 million people may have DM by the year 2030. Several classes of drugs such as sulfonylureas, meglitinides, thiazolidinediones etc. Read More

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Evaluation of the developmental toxicity of solvents, metals, drugs, and industrial chemicals using a freshwater snail () assay.

J Toxicol Environ Health A 2022 Jun 19:1-17. Epub 2022 Jun 19.

Department of Biological Sciences, National School of Public Health, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil.

A freshwater snail assay was employed to assess the embryotoxicity of solvents including acetone, methanol, ethanol, isopropanol, dimethyl-sulfoxide, glycerin, metals/metalloids including mercuric chloride (HgCl), cadmium chloride (CdCl,), antimony salts Sb and Sb, drugs including colchicine, hydroxyurea, cyclophosphamide, an industrial chemical sodium azide (SA), an anionic surfactant dodecyl sodium sulfate-(DSS), HO and sodium chloride (NaCl). The assay consists of exposing egg masses (EM) to the substances for 96-hr and following up embryo/snail development for lethality, abnormal morphology (teratogenicity), and day of hatching up to day 10 or 14 after spawning. Based upon concentration-response relationships, LCs (embryolethality), ECs (teratogenicity) and ICs (hatching retardation) and 95%CIs were determined for tested chemicals. Read More

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A Novel Chinese Herbal and Corresponding Chemical Formula for Cancer Treatment by Targeting Tumor Maintenance, Progression, and Metastasis.

Front Pharmacol 2022 26;13:907826. Epub 2022 May 26.

TCM division, Jin-Mi company, Taipei, Taiwan.

We characterized a so-called "heirloom recipe" Chinese herbal formula (temporarily named Formula X) that contains five Chinese medical botanical drugs, Huang-Lian ( Franch. [Ranunculaceae]), Huang-Qin ( Georgi [Lamiaceae]), Bai-Wei ( (Bunge) C. Morren and Decne. Read More

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A novel nanoluciferase transgenic reporter measures proteinuria in zebrafish.

Kidney Int 2022 Jun 15. Epub 2022 Jun 15.

Wellcome Centre for Cell-Matrix Research, Division of Cell-Matrix Biology and Regenerative Medicine, School of Biological Sciences, Faculty of Biology Medicine and Health, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK; Department of Paediatric Nephrology, Royal Manchester Children's Hospital, Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK. Electronic address:

The zebrafish is an important animal system for modelling human diseases. This includes kidney dysfunction as the embryonic kidney (pronephros) shares considerable molecular and morphological homology with the human nephron. A key clinical indicator of kidney disease is proteinuria, but a high-throughput readout of proteinuria in the zebrafish is currently lacking. Read More

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Supporting discovery and development of medical countermeasures for chemical injury to eye and skin.

Exp Eye Res 2022 Jun 15;221:109156. Epub 2022 Jun 15.

Department of Health and Human Services, National Institute of Allergy and Infectious Diseases/National Institutes of Health (NIAID/NIH), 5601 Fishers Lane, Bethesda, MD, 20892, United States. Electronic address:

Vesicants, from vesica (Latin for blister), can cause local and systemic toxicity. They include the chemotherapy drug nitrogen mustard and chemical warfare agents sulfur mustard, Lewisite, and phosgene oxime. These agents are commonly released in vapor form and consequently, eyes and skin are the most vulnerable. Read More

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Identifying crucial biomarkers in peripheral blood of schizophrenia and screening therapeutic agents by comprehensive bioinformatics analysis.

J Psychiatr Res 2022 Jun 9;152:86-96. Epub 2022 Jun 9.

Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun, 130021, China. Electronic address:

Schizophrenia (SCZ) is a sophisticated neurodevelopmental disorder, but the mechanisms remain ambiguous. Thus, we analyzed the transcriptomic datasets to investigate the molecular mechanisms of SCZ to pinpoint novel biomarkers and suggest treatment agents. Four peripheral blood datasets were retrieved from the Gene Expression Omnibus (GEO) database, altogether 27 robust Differentially Expressed Genes (DEGs) were ascertained by robust rank aggregation (RRA) methodology. Read More

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Multi-scale convolution neural network with residual modules for determination of drugs in human hair using surface-enhanced Raman spectroscopy with a gold nanorod film self-assembled by inverted evaporation.

Spectrochim Acta A Mol Biomol Spectrosc 2022 Jun 4;280:121463. Epub 2022 Jun 4.

National Engineering Research Center for Agro-Ecological Big Data Analysis & Application, Anhui University, Hefei 230601, People's Republic of China. Electronic address:

Detection of illegal drug users is crucial in controlling drug-related crimes, reducing drug prevalence, and protecting human lives to ensure social stability. In this study, surface-enhanced Raman spectroscopy (SERS) and deep learning networks were employed to determine methamphetamine, ketamine, and morphine in human hair. Drugs were obtained from hair through alkaline hydrolysis and liquid-liquid extraction, and gold nanorods were employed to prepare the self-assembled film as the SERS substrate by inverted evaporation. Read More

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Association of VEGF Gene Polymorphism (rs699947) with Glaucoma and In-Silico Study of Antiglaucoma Bioactive Compounds.

Appl Biochem Biotechnol 2022 Jun 17. Epub 2022 Jun 17.

Institute of Microbiology and Molecular Genetics, University of the Punjab, Lahore, 54590, Pakistan.

Vascular endothelial growth factor (VEGF) is a useful expert in various maturation and other problems such as glaucoma. VEGF gene is located on the short arm of chromosome 6. It has 8 exons and 6 introns. Read More

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Comparative evaluation of biomedical and phytochemical applications of zinc nanoparticles by using Fagonia cretica extracts.

Sci Rep 2022 Jun 15;12(1):10024. Epub 2022 Jun 15.

Department of Biology, Science Unit, Deanship of Educational Services, Qassim University, Buraydah, 51452, Saudi Arabia.

The use of the green approach for nanoparticle synthesis yielded noticeable concern due to its eco-friendliness, cost-effectiveness, and reduced production of toxic chemicals. The current study was designed to formulate Zinc oxide nanoparticles (ZnO NPs) by using Fagonia cretica extracts, evaluating its phytochemical content, and different biological activities. Four different solvents; methanol (MeOH), n-Hexane (n-H), aqueous (Aq), and ethyl acetate (EA), had been utilized in the extracting method. Read More

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Very rapid synthesis of highly efficient and biocompatible AgSe QD phytocatalysts using ultrasonic irradiation for aqueous/sustainable reduction of toxic nitroarenes to anilines with excellent yield/selectivity at room temperature.

Ultrason Sonochem 2022 Jun 18;87:106037. Epub 2022 May 18.

Department of Phytochemistry, Medicinal Plants and Drugs Research Institute, Shahid Beheshti University, Evin, Tehran, Iran. Electronic address:

There are many problems associated with the synthesis of nanocatalysts and catalytic reduction of nitroarenes - e.g., high temperatures, costs, long reaction/synthesis process times, the toxicity of chemicals/solvents, undesirable byproducts, the toxic/harmful wastes, low efficiency/selectivity, etc. Read More

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Nanochitin and poly(N-isopropylacrylamide) interpenetrating network hydrogels for temperature sensor applications.

Carbohydr Polym 2022 Sep 30;291:119544. Epub 2022 Apr 30.

Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, International Innovation Center for Forest Chemicals and Materials, College of Chemical Engineering, Nanjing Forestry University, Longpan Road 159, Nanjing 210037, China; Nanjing Forestry University, Longpan Road 159, Nanjing, China. Electronic address:

A strengthened interpenetrating network of 2,2,6,6-tetramethyl-piperidine-1-oxyl (TEMPO)-oxidized nanochitin (TOChN) with poly(N-isopropylacrylamide) (PNIPAm) chains was constructed in an acetic acid coagulation bath to fabricate hydrogels. The TOChN increased the water retention of the PNIPAm hydrogels while maintaining the lower critical solution temperature (LCST) at approximately 34 °C. The storage modulus and compression stress of the 0. Read More

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September 2022

Liver organ-on-chip models for toxicity studies and risk assessment.

Lab Chip 2022 Jun 13. Epub 2022 Jun 13.

Université de Technologie de Compiègne, CNRS, Biomechanics and Bioengineering, Centre de Recherche Royallieu CS 60319, 60203 Compiègne Cedex, France.

The liver is a key organ that plays a pivotal role in metabolism and ensures a variety of functions in the body, including homeostasis, synthesis of essential components, nutrient storage, and detoxification. As the centre of metabolism for exogenous molecules, the liver is continuously exposed to a wide range of compounds, such as drugs, pesticides, and environmental pollutants. Most of these compounds can cause hepatotoxicity and lead to severe and irreversible liver damage. Read More

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Resistance to dicyclanil and imidacloprid in the sheep blowfly, Lucilia cuprina, in Australia.

Pest Manag Sci 2022 Jun 11. Epub 2022 Jun 11.

Elanco Australasia Pty Ltd., Macquarie Park, NSW, 2113.

Background: The sheep blowfly, Lucila cuprina, is a myiasis-causing parasite responsible for significant production losses and welfare issues for the Australian sheep industry. Control relies largely on the use of insecticides. The pyrimidine compound, dicyclanil, is the predominant control chemical, although other insecticides are also used, including imidacloprid, ivermectin, cyromazine and spinosad. Read More

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Repeatable detection of Ag ions using a DNA aptamer-linked hydrogel biochemical sensor integrated with microfluidic heating system.

Sci Rep 2022 Jun 11;12(1):9692. Epub 2022 Jun 11.

Graduate School of Integrated Design Engineering, Keio University, 3-14-1 Hiyoshi, Kohoku-Ku, Yokohama, 223-8522, Japan.

This paper describes repeatable detection of Ag ions using a DNA aptamer-linked hydrogel biochemical sensor integrated with a microfluidic heating system. Biochemical sensors that respond to chemical compounds and produce detectable signals have a critical role in many aspects of modern society. In particular, the repeatable measurement of environmental information such as toxic substances including Ag ions could be expected to improve the environment. Read More

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Bio-nano scale modifications of melittin for improving therapeutic efficacy.

Expert Opin Biol Ther 2022 Jun 16:1-15. Epub 2022 Jun 16.

Connective Tissue Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

Introduction: Melittin (MLT), a natural membrane-active component, is the most prominent cytolytic peptide from bee venom. Remarkable biological properties of MLT, including anti-inflammatory, antimicrobial, anticancer, anti-protozoan, and antiarthritic activities, make it an up-and-coming therapeutic candidate for a wide variety of human diseases. Therapeutic applications of MLT may be hindered due to low stability, high toxicity, and weak tissue penetration. Read More

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Perfluorocarbon Nanodroplets for Dual Delivery with Ultrasound/GSH-Responsive Release of Model Drug and Passive Release of Nitric Oxide.

Polymers (Basel) 2022 May 31;14(11). Epub 2022 May 31.

Research Center for Green Fine Chemicals, Korea Research Institute of Chemical Technology, Ulsan 44412, Korea.

Nitric oxide (NO) plays a critical role as an important signaling molecule for a variety of biological functions, particularly inhibiting cell proliferation or killing target pathogens. To deliver active radical NO gaseous molecule whose half-life is a few seconds in a stable state, the design and development of effective exogenous NO supply nanocarriers are essential. Additionally, the delivery of desired drugs with NO can produce synergistic effects. Read More

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Strengthening Australia's Chemical Regulation.

Int J Environ Res Public Health 2022 May 30;19(11). Epub 2022 May 30.

Medical School, Australian National University, Florey Building 54 Mills Road, Acton, ACT 2601, Australia.

Humans are exposed to a myriad of chemicals every day, some of which have been established to have deleterious effects on human health. Regulatory frameworks play a vital role in safeguarding human health through the management of chemicals and their risks. For this review, we focused on agricultural and veterinary (Agvet) chemicals and industrial chemicals, which are regulated, respectively, by the Australian Pesticides and Veterinary Medicines Authority (APVMA), and the Australian Industrial Chemicals Introduction Scheme (AICIS). Read More

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Role of Nrf2 in bisphenol effects: a review study.

Environ Sci Pollut Res Int 2022 Jun 9. Epub 2022 Jun 9.

Healthy Ageing Research Centre, Neyshabur University of Medical Sciences, Neyshabur, Iran.

Bisphenols (BPs), the main endocrine-disrupting chemicals used in polycarbonate plastics, epoxy-phenol resins, and some other manufacturers, have been interestingly focused to find their toxic effects in recent years. Due to the strong relation between bisphenols and some crucial receptors such as ERs, AR, glucocorticoid receptor, THRs, ERRs, hPXR, AhR, and etcetera, the disrupting and oncogenic role of these chemicals on reproductive, respiratory, and circulatory systems and a broad group of body tissues have been investigated. BPs induce oxidant enzymes, exert antioxidant enzymes from body cells, and result in the expression of proinflammatory genes, leading to cell apoptosis and inflammation. Read More

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Exploring the plant-derived bioactive substances as antidiabetic agent: An extensive review.

Biomed Pharmacother 2022 Aug 6;152:113217. Epub 2022 Jun 6.

Department of Chemistry, University of Swabi, Anbar, Swabi, KPK, Pakistan. Electronic address:

Diabetes mellitus (DM) is a metabolic syndrome. Diabetes has become more common in recent years. Chemically generated drugs are used to lessen the effects of DM and its following repercussions due to unpleasant side effects such as weight gain, gastrointestinal issues, and heart failure. Read More

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Chemotactic self-caging in active emulsions.

Proc Natl Acad Sci U S A 2022 Jun 9;119(24):e2122269119. Epub 2022 Jun 9.

Department of Complex Fluids, Max Planck Institute for Dynamics and Self-Organization, 37077 Göttingen, Germany.

A common feature of biological self-organization is how active agents communicate with each other or their environment via chemical signaling. Such communications, mediated by self-generated chemical gradients, have consequences for both individual motility strategies and collective migration patterns. Here, in a purely physicochemical system, we use self-propelling droplets as a model for chemically active particles that modify their environment by leaving chemical footprints, which act as chemorepulsive signals to other droplets. Read More

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Scutellaria baicalensis and its constituents baicalin and baicalein as antidotes or protective agents against chemical toxicities: a comprehensive review.

Naunyn Schmiedebergs Arch Pharmacol 2022 Jun 9. Epub 2022 Jun 9.

Pharmaceutical Research Center, Institute of Pharmaceutical Technology, Mashhad University of Medical Sciences, Mashhad, Iran.

Scutellaria baicalensis (SB), also known as the Chinese skullcap, has a long history of being used in Chinese medicine to treat a variety of conditions ranging from microbial infections to metabolic syndrome and malignancies. Numerous studies have reported that treatment with total SB extract or two main flavonoids found in its root and leaves, baicalin (BA) and baicalein (BE), can prevent or alleviate the detrimental toxic effects of exposure to various chemical compounds. It has been shown that BA and BE are generally behind the protective effects of SB against toxicants. Read More

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A review on the potential of underutilized Blackjack naturally occurring in sub-Saharan Africa.

Heliyon 2022 Jun 29;8(6):e09586. Epub 2022 May 29.

Department of Chemistry, College of Natural and Mathematical Sciences, The University of Dodoma, Tanzania.

Several Indigenous edible vegetables in sub-Saharan countries have potential bioactive compounds, including underutilized Bioactives from Indigenous edible are re-evolving as an alternative medicine potential for drug formulations. BP has also been used to mitigate over 40 different diseases in people and animals as herbal medication. Due to globalization and urbanization, people move from more active to more sedentary lifestyles, home-cooked meals to fast foods and snacks, organic foods to processed food with high sugar, salt, and fat. Read More

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Cucurbit[7]uril-Mediated Supramolecular Bactericidal Nanoparticles: Their Assembly Process, Controlled Release, and Safe Treatment of Intractable Plant Bacterial Diseases.

Nano Lett 2022 Jun 6;22(12):4839-4847. Epub 2022 Jun 6.

State Key Laboratory Breeding Base of Green Pesticide and Agricultural Bioengineering, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Center for R&D of Fine Chemicals of Guizhou University, Guiyang 550025, China.

A safe, biocompatible, and stimuli-responsive cucurbit[7]uril-mediated supramolecular bactericidal nanoparticle was fabricated by encapsulating a highly bioactive carbazole-decorated imidazolium salt (, EC = 0.647 μg/mL against phytopathogen pv ) into the host cucurbit[7]uril (CB[7]), thereby leading to self-assembled topographies from microsheets () to nanospheroidal architectures (@CB[7]). The assembly behaviors were elucidated by acquired single-crystal structures, H NMR, ITC, and X-ray powder diffraction experiments. Read More

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Red-Light-Responsive Metallopolymer Nanocarriers with Conjugated and Encapsulated Drugs for Phototherapy Against Multidrug-Resistant Tumors.

Small 2022 Jun 3:e2201672. Epub 2022 Jun 3.

Max Planck Institute for Polymer Research, Ackermannweg 10, 55128, Mainz, Germany.

It is challenging to treat multidrug-resistant tumors because such tumors are resistant to a broad spectrum of structurally and functionally unrelated drugs. Herein, treatment of multidrug-resistant tumors using red-light-responsive metallopolymer nanocarriers that are conjugated with the anticancer drug chlorambucil (CHL) and encapsulated with the anticancer drug doxorubicin (DOX) is reported. An amphiphilic metallopolymer PolyRuCHL that contains a poly(ethylene glycol) (PEG) block and a red-light-responsive ruthenium (Ru)-containing block is synthesized. Read More

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A Resource to Infer Molecular Paths Linking Cancer Mutations to Perturbation of Cell Metabolism.

Front Mol Biosci 2022 18;9:893256. Epub 2022 May 18.

Department of Biology, University of Rome Tor Vergata, Rome, Italy.

Some inherited or somatically-acquired gene variants are observed significantly more frequently in the genome of cancer cells. Although many of these cannot be confidently classified as driver mutations, they may contribute to shaping a cell environment that favours cancer onset and development. Understanding how these gene variants causally affect cancer phenotypes may help developing strategies for reverting the disease phenotype. Read More

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Discovery of the cyclotide caripe 11 as a ligand of the cholecystokinin-2 receptor.

Sci Rep 2022 Jun 2;12(1):9215. Epub 2022 Jun 2.

Center for Physiology and Pharmacology, Medical University of Vienna, 1090, Vienna, Austria.

The cholecystokinin-2 receptor (CCKR) is a G protein-coupled receptor (GPCR) that is expressed in peripheral tissues and the central nervous system and constitutes a promising target for drug development in several diseases, such as gastrointestinal cancer. The search for ligands of this receptor over the past years mainly resulted in the discovery of a set of distinct synthetic small molecule chemicals. Here, we carried out a pharmacological screening of cyclotide-containing plant extracts using HEK293 cells transiently-expressing mouse CCKR, and inositol phosphate (IP1) production as a readout. Read More

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