12,193 results match your criteria Drugs and Chemicals


Protecting the environment from psychoactive drugs: Problems for regulators illustrated by the possible effects of tramadol on fish behaviour.

Sci Total Environ 2019 Feb 6;664:915-926. Epub 2019 Feb 6.

Institute of Environment, Health and Societies, Brunel University London, Uxbridge, Middlesex, UB8 3PH, United Kingdom.

There is concern that psychoactive drugs present in the aquatic environment could affect the behaviour of fish, and other organisms, adversely. There is considerable experimental support for this concern, although the literature is not consistent. To investigate why, fish were exposed to three concentrations of the synthetic opiate tramadol for 23-24 days, and their anxiolytic behaviour in a novel tank diving test was assessed both before and after exposure. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2019.02.090DOI Listing
February 2019

d-Amphetamine and methylmercury exposure during adolescence alters sensitivity to monoamine uptake inhibitors in adult mice.

Neurotoxicology 2019 Feb 12. Epub 2019 Feb 12.

Department of Psychology, Auburn University, Auburn, AL, United States.

Gestational exposure to methylmercury (MeHg), an environmental neurotoxicant, and adolescent administration of d-amphetamine (d-AMP) disrupt dopamine neurotransmission and alter voluntary behavior in adult rodents. We determined the impact of adolescent exposure to MeHg and d-AMP on monoamine neurotransmission in mice by assessing sensitivity to acute d-AMP, desipramine, and clomipramine, drugs that target dopamine, norepinephrine, and serotonin reuptake, respectively. Male C57Bl/6n mice were given 0 (control) or 3 ppm MeHg via drinking water from postnatal day 21 to 60 (murine adolescence). Read More

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http://dx.doi.org/10.1016/j.neuro.2019.02.001DOI Listing
February 2019

Development of a non-human primate model to support CNS translational research: Demonstration with D-amphetamine exposure and dopamine response.

J Neurosci Methods 2019 Feb 12. Epub 2019 Feb 12.

Mylan School of Pharmacy and Graduate School of Pharmaceutical Sciences, Division of Pharmaceutical, Administrative and Social Sciences, Duquesne University, Pittsburgh, PA, USA. Electronic address:

Background: Challenges specific to the discovery and development of candidate CNS drugs have led to implementation of various in silico, in vitro and in vivo approaches to improve the odds for commercialization of novel treatments.

New Method: Advances in analytical methodology and microdialysis probe design have enabled development of a non-human primate model capable of measuring concentrations of drugs or endogenous chemicals in brain extracellular fluid (ECF) and cerebrospinal fluid (CSF). Linking these to population modeling reduces animal numbers to support predictive translational sciences in primates. Read More

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http://dx.doi.org/10.1016/j.jneumeth.2019.02.005DOI Listing
February 2019

Exploring Cancer Cell Behavior In Vitro in Three-Dimensional Multicellular Bioprintable Collagen-Based Hydrogels.

Cancers (Basel) 2019 Feb 5;11(2). Epub 2019 Feb 5.

Fondazione Instituto di Ricerca Pediatrica Citta' della Speranza, Neuroblastoma Laboratory, 35127 Padua, Italy.

In vitro cancer 3D models are valuable tools to provide mechanistic insight into solid tumor growth, invasion, and drug delivery. The 3D spheroid model of solid tumors has been the most popular cancer model in use until now. However, previous studies have shown that these spheroid models lack sufficient morphological parameters, which may affect their response to chemicals. Read More

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http://dx.doi.org/10.3390/cancers11020180DOI Listing
February 2019

Adulation or Adulteration? Representing Chemical Dyes in the Victorian Media.

Authors:
Carolyn Cobbold

Ambix 2019 Feb 13:1-28. Epub 2019 Feb 13.

a Cambridge University , Cambridge , UK.

This essay describes how the Victorian media reported on the transformation of coal tar into a synthetic palette of colours in the form of aniline and azo dyes. These dyes were the first of many new chemical substances including drugs, perfumes, and flavourings, which chemists began to synthesise and produce on an industrial scale from a waste product of the coal gas industry. Although intended for use in the textile industry, the new dyes soon began to be added to food, becoming one of the first examples of laboratory-created, industrially manufactured chemicals to permeate our daily life in unexpected ways. Read More

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http://dx.doi.org/10.1080/00026980.2019.1574385DOI Listing
February 2019

Pattern of Anaemia in Chronic Kidney Disease.

Mymensingh Med J 2019 Jan;28(1):1-7

Dr Mohammad Omar Faruque Miah, Senior Clinical Pathologist, Mymensingh Medical College Hospital, Mymensingh, Bangladesh.

The prevalence of chronic kidney disease (CKD) in Bangladesh is increasing. Chronic kidney disease refers to an irreversible deterioration in renal function which classically develops over a period of years. Initially, it manifest's only as a biochemical abnormality. Read More

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January 2019

Identification of novel lysine demethylase 5-selective inhibitors by inhibitor-based fragment merging strategy.

Bioorg Med Chem 2019 Feb 4. Epub 2019 Feb 4.

Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 1-5 Shimogamo-hangi-cho, Sakyo-ku, Kyoto 603-0823, Japan; CREST, Japan Science and Technology Agency (JST), 4-1-8 Honcho, Kawaguchi, Saitama 332-0012, Japan. Electronic address:

Histone lysine demethylases (KDMs) have drawn much attention as targets of therapeutic agents. KDM5 proteins, which are Fe(II)/α-ketoglutarate-dependent demethylases, are associated with oncogenesis and drug resistance in cancer cells, and KDM5-selective inhibitors are expected to be anticancer drugs. However, few cell-active KDM5 inhibitors have been reported and there is an obvious need to discover more. Read More

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http://dx.doi.org/10.1016/j.bmc.2019.02.006DOI Listing
February 2019
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The impact of temperature on the transformation of illicit drug biomarkers in wastewater.

Sci Total Environ 2018 Dec 23;644:1612-1616. Epub 2018 Jul 23.

Department of Environmental Engineering, Technical University of Denmark, Bygningstorvet 115, 2800 Kongens Lyngby, Denmark; Department of Chemical Engineering, University of Bath, Claverton Down, Bath BA2 7AY, UK. Electronic address:

Temperature is one of the key factors, influencing the transformation kinetics of organic chemicals. In the context of wastewater-based epidemiology, however, temperature differences among sewer catchments and within the same catchment (due to, e.g. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2018.06.307DOI Listing
December 2018
1 Read

Assessment of human estrogen receptor agonistic/antagonistic effects of veterinary drugs used for livestock and farmed fish by OECD in vitro stably transfected transcriptional activation assays.

Toxicol In Vitro 2019 Feb 8. Epub 2019 Feb 8.

Food Safety Risk Assessment Division, National Institute of Food and Drug Safety Evaluation, Chungcheongbuk-do 28159, Republic of Korea. Electronic address:

The presence of veterinary drug residues in foods and the environment could potentially cause adverse effects on humans and wildlife. Several veterinary drugs were reported to exhibit endocrine disrupting effects via binding affinities to sexual hormone receptors such as estrogen and androgen receptors. Therefore, we confirmed the human estrogen receptor (ER) agonistic/antagonistic effects of 135 chemicals that were used as veterinary drugs in Korea by the official Organization for Economic Cooperation and Development (OECD) in vitro ER transcriptional activation (TA) assay using the VM7Luc4E2 cell line. Read More

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http://dx.doi.org/10.1016/j.tiv.2019.02.003DOI Listing
February 2019
1 Read

Testosterone disruptor effect and gut microbiome perturbation in mice: Early life exposure to doxycycline.

Chemosphere 2019 Jan 18;222:722-731. Epub 2019 Jan 18.

Institute of Food Safety and Nutrition, Jiangsu Academy of Agricultural Sciences, Nanjing, Jiangsu, China; Key Lab of Food Quality and Safety of Jiangsu Province-State Key Laboratory Breeding Base, Risk Assessment Laboratory of Agro-Products Processing Quality and Safety (Nanjing), Ministry of Agriculture, Nanjing, Jiangsu, China. Electronic address:

Veterinary tetracyclines drugs are emerging organic pollutants detected at high concentrations in the urine of school children and a potential public health risk. However, the implications of early-life exposure to tetracyclines on testosterone production, being new endocrine disruptors, remain unknown. We investigated whether the early-life exposure to low-doxycycline, a widely used tetracycline, on mitochondria dysfunction and testosterone disruption in Leydig cells in vitro and in vivo. Read More

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http://dx.doi.org/10.1016/j.chemosphere.2019.01.101DOI Listing
January 2019
1 Read

Effects of acetaminophen in oxidative stress and neurotoxicity biomarkers of the gastropod Phorcus lineatus.

Environ Sci Pollut Res Int 2019 Feb 8. Epub 2019 Feb 8.

Departamento de Biologia, Universidade de Aveiro, Campus de Santiago, 3810-193, Aveiro, Portugal.

The growing use of pharmaceutical drugs has become a major environmental issue considering that these substances (or their metabolites) end up inevitably in sewage waters after excretion. In the wild, these chemicals may affect non-target organisms, and their potential toxicity is not sufficiently studied, a reality that is particularly true for marine organisms. Acetaminophen (also known as paracetamol) is known to be toxic in high dosages, namely, by triggering oxidative effects. Read More

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http://dx.doi.org/10.1007/s11356-019-04349-1DOI Listing
February 2019
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Novel insights into P450 BM3 interactions with FDA-approved antifungal azole drugs.

Sci Rep 2019 Feb 7;9(1):1577. Epub 2019 Feb 7.

Centre for Synthetic Biology of Fine and Specialty Chemicals (SYNBIOCHEM), Manchester Institute of Biotechnology, School of Chemistry, The University of Manchester, Manchester, M1 7DN, United Kingdom.

Flavocytochrome P450 BM3 is a natural fusion protein constructed of cytochrome P450 and NADPH-cytochrome P450 reductase domains. P450 BM3 binds and oxidizes several mid- to long-chain fatty acids, typically hydroxylating these lipids at the ω-1, ω-2 and ω-3 positions. However, protein engineering has led to variants of this enzyme that are able to bind and oxidize diverse compounds, including steroids, terpenes and various human drugs. Read More

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http://dx.doi.org/10.1038/s41598-018-37330-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367340PMC
February 2019
1 Read

Drug discovery technologies to identify and characterize modulators of the pregnane X receptor and the constitutive androstane receptor.

Drug Discov Today 2019 Feb 4. Epub 2019 Feb 4.

Department of Chemical Biology & Therapeutics, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA. Electronic address:

The pregnane X receptor (PXR) and the constitutive androstane receptor (CAR) are ligand-activated nuclear receptors (NRs) that are notorious for their role in drug metabolism, causing unintended drug-drug interactions and decreasing drug efficacy. They control the xenobiotic detoxification system by regulating the expression of an array of drug-metabolizing enzymes and transporters that excrete exogenous chemicals and maintain homeostasis of endogenous metabolites. Much effort has been invested in recognizing potential drugs for clinical use that can activate PXR and CAR to enhance the expression of their target genes, and in identifying PXR and CAR inhibitors that can be used as co-therapeutics to prevent adverse effects. Read More

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http://dx.doi.org/10.1016/j.drudis.2019.01.021DOI Listing
February 2019
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Tailored 3D printed micro-crystallization chip for versatile and high-efficiency droplet evaporative crystallization.

Lab Chip 2019 Feb 7. Epub 2019 Feb 7.

State Key Laboratory of Fine Chemicals, Engineering Laboratory for Petrochemical Energy-efficient Separation Technology of Liaoning Province, School of Chemical Engineering, Dalian University of Technology, Dalian, Liaoning 116024, China.

Droplet evaporative crystallization on a micro-structured platform with limited interfacial area has potential applications in crystallization theory, bioengineering, and particle drug preparation. Here, an efficient and versatile approach is discussed for multiple drop-evaporative crystallization processes on a micro-crystallization chip fabricated via three-dimensional printing. A chip with limited interfacial area could be fabricated on a highly controlled crystallizer interface. Read More

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http://dx.doi.org/10.1039/c8lc01319eDOI Listing
February 2019
1 Read

Liposome-Mediated Drug Delivery in Larval Zebrafish to Manipulate Macrophage Function.

Zebrafish 2019 Feb 6. Epub 2019 Feb 6.

2 Department of Molecular Medicine and Pathology, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.

Chemical interventions are regularly used to examine and manipulate macrophage function in larval zebrafish. Given chemicals are typically administered by simple immersion or injection, it is not possible to resolve whether their impact on macrophage function is direct or indirect. Liposomes provide an attractive strategy to target drugs to specific cellular compartments, including macrophages. Read More

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http://dx.doi.org/10.1089/zeb.2018.1681DOI Listing
February 2019
2 Reads

Chemical-PDMS binding kinetics and implications for bioavailability in microfluidic devices.

Lab Chip 2019 Feb 5. Epub 2019 Feb 5.

Department of Physics and Astronomy, Vanderbilt University, Nashville, TN, USA.

Microfluidic organ-on-chip devices constructed from polydimethylsiloxane (PDMS) have proven useful in studying both beneficial and adverse effects of drugs, supplements, and potential toxicants. Despite multiple advantages, one clear drawback of PDMS-based devices is binding of hydrophobic chemicals to their exposed surfaces. Chemical binding to PDMS can change the timing and extent of chemical delivery to cells in such devices, potentially altering dose-response curves. Read More

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http://xlink.rsc.org/?DOI=C8LC00796A
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http://dx.doi.org/10.1039/c8lc00796aDOI Listing
February 2019
2 Reads

Structural insights into FTO's catalytic mechanism for the demethylation of multiple RNA substrates.

Proc Natl Acad Sci U S A 2019 Feb 4. Epub 2019 Feb 4.

Synthetic and Functional Biomolecules Center, Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China;

FTO demethylates internal -methyladenosine (mA) and ,2'--dimethyladenosine (mA; at the cap +1 position) in mRNA, mA and mA in snRNA, and -methyladenosine (mA) in tRNA in vivo, and in vitro evidence supports that it can also demethylate -methyldeoxyadenosine (6mA), 3-methylthymine (3mT), and 3-methyluracil (mU). However, it remains unclear how FTO variously recognizes and catalyzes these diverse substrates. Here we demonstrate-in vitro and in vivo-that FTO has extensive demethylation enzymatic activity on both internal mA and cap mA Considering that 6mA, mA, and mA all share the same nucleobase, we present a crystal structure of human FTO bound to 6mA-modified ssDNA, revealing the molecular basis of the catalytic demethylation of FTO toward multiple RNA substrates. Read More

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http://dx.doi.org/10.1073/pnas.1820574116DOI Listing
February 2019
1 Read
9.809 Impact Factor

Human cytochrome P450 enzymes 5-51 as targets of drugs and natural and environmental compounds: mechanisms, induction, and inhibition - toxic effects and benefits.

Drug Metab Rev 2018 Aug;50(3):256-342

b Department of Biochemistry , Vanderbilt University School of Medicine , Nashville , TN , USA.

Cytochrome P450 (P450, CYP) enzymes have long been of interest due to their roles in the metabolism of drugs, pesticides, pro-carcinogens, and other xenobiotic chemicals. They have also been of interest due to their very critical roles in the biosynthesis and metabolism of steroids, vitamins, and certain eicosanoids. This review covers the 22 (of the total of 57) human P450s in Families 5-51 and their substrate selectivity. Read More

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http://dx.doi.org/10.1080/03602532.2018.1483401DOI Listing
August 2018
1 Read

Characteristics of a Novel Manganese Superoxide Dismutase of a Hadal Sea Cucumber ( sp.) from the Mariana Trench.

Mar Drugs 2019 Feb 1;17(2). Epub 2019 Feb 1.

Institute of Deep-Sea Science and Engineering, Chinese Academy of Sciences, Sanya 572000, China.

A novel, cold-adapted, and acid-base stable manganese superoxide dismutase (Ps-Mn-SOD) was cloned from hadal sea cucumber sp. The dimeric recombinant enzyme exhibited approximately 60 kDa in molecular weight, expressed activity from 0 °C to 70 °C with an optimal temperature of 0 °C, and resisted wide pH values from 2.2⁻13. Read More

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http://www.mdpi.com/1660-3397/17/2/84
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http://dx.doi.org/10.3390/md17020084DOI Listing
February 2019
2 Reads

Acute and subacute effects of drugs in embryos of Danio rerio. QSAR grouping and modelling.

Ecotoxicol Environ Saf 2019 Jan 31;172:232-239. Epub 2019 Jan 31.

Universidad San Jorge, Campus Universitario, Autov A23 km 299, 50830, Villanueva de Gállego, Zaragoza, Spain. Electronic address:

The final fate of many drugs is release into the natural aquatic environment. It is necessary to assess the toxicity caused by this situation and the associated concerns for human beings. Zebrafish (Danio rerio) is a common biomodel used to assess toxicity in aquatic environments. Read More

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http://dx.doi.org/10.1016/j.ecoenv.2019.01.081DOI Listing
January 2019
1 Read

Ecotoxicity risk of presence of two cytostatic drugs: Bleomycin and vincristine and their binary mixture in aquatic environment.

Ecotoxicol Environ Saf 2019 Jan 30;172:210-215. Epub 2019 Jan 30.

Environmental Biotechnology Department, Faculty of Energy and Environmental Engineering, The Silesian University of Technology, Akademicka 2 A Str., 44-100 Gliwice, Poland; The Biotechnology Centre, The Silesian University of Technology, Krzywoustego 8 St., 44-100 Gliwice, Poland. Electronic address:

Cytostatic drugs have become one of the greatest environmental threats. They occur in surface, ground and even drinking water. Their key emission sources are hospital effluents, municipal wastewater, as well as drug manufacturers and their effluents. Read More

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http://dx.doi.org/10.1016/j.ecoenv.2019.01.074DOI Listing
January 2019
1 Read

Novel Drugs of Abuse.

Pediatr Rev 2019 Feb;40(2):71-78

Rocky Mountain Poison and Drug Center, Denver Health Hospital, Denver, CO.

Novel drugs of abuse are synthetic illicit drugs, or analogues of known illicit drugs, that can be more potent. Novel drugs of abuse are often labeled as or They are often sold as designated legal or nondrug products, such as incense, plant food, or bath salts, with labeling such as "Not for Human Consumption" or "For Use in Research Only." The prevalence of use of novel drugs of abuse is difficult to determine because specific drugs, compounds, and availability of these drugs are constantly evolving. Read More

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http://dx.doi.org/10.1542/pir.2018-0050DOI Listing
February 2019
1 Read

Network Analysis Reveals TNF as a Major Hub of Reactive Inflammation Following Spinal Cord Injury.

Sci Rep 2019 Jan 30;9(1):928. Epub 2019 Jan 30.

Shanghai Institute of Applied Mathematics and Mechanics, Shanghai University, Shanghai, 200072, P. R. China.

Spinal cord injury (SCI) leads to reactive inflammation and other harmful events that limit spinal cord regeneration. We propose an approach for studying the mechanisms at the levels of network topology, gene ontology, signaling pathways, and disease inference. We treated inflammatory mediators as toxic chemicals and retrieved the genes and interacting proteins associated with them via a set of biological medical databases and software. Read More

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http://dx.doi.org/10.1038/s41598-018-37357-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354014PMC
January 2019
1 Read

Inhibition of Classical and Alternative Modes of Respiration in Leads to Cell Wall Remodeling and Increased Macrophage Recognition.

MBio 2019 Jan 29;10(1). Epub 2019 Jan 29.

Kent Fungal Group, School of Biosciences, University of Kent, Kent, United Kingdom

The human fungal pathogen requires respiratory function for normal growth, morphogenesis, and virulence. Mitochondria therefore represent an enticing target for the development of new antifungal strategies. This possibility is bolstered by the presence of characteristics specific to fungi. Read More

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http://dx.doi.org/10.1128/mBio.02535-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355986PMC
January 2019
1 Read

A practice of expert review by read-across using QSAR Toolbox.

Mutagenesis 2019 Jan 23. Epub 2019 Jan 23.

Division of Pharmacopoeia and Standards for Drugs, Pharmaceuticals and Medical Devices Agency, Shin-Kasumigaseki Building, Kasumigaseki, Chiyoda-ku, Tokyo, Japan.

The International Council for Harmonisation of Technical Requirement for Pharmaceuticals for Human Use (ICH) M7 guideline on 'Assessment and Control of DNA Reactive (Mutagenic) Impurities in Pharmaceuticals to Limit Potential Carcinogenic Risk' provides the application of two types of quantitative structure-activity relationship (QSAR) systems (rule- and statistics-based) as an alternative to the Ames test for evaluating the mutagenicity of impurities in pharmaceuticals. M7 guideline also states that the expert reviews can be applied when the outcomes of the two QSAR analyses show any conflicting or inconclusive prediction. However, the guideline does not provide any information of how to conduct expert reviews. Read More

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http://dx.doi.org/10.1093/mutage/gey046DOI Listing
January 2019
2 Reads

Systems Pharmacology Dissection of Multi-Scale Mechanisms of Action of Formula for the Treatment of Gastrointestinal Diseases.

Front Pharmacol 2018 11;9:1448. Epub 2019 Jan 11.

Key Laboratory of Industrial Ecology and Environmental Engineering, Faculty of Chemical, Environmental and Biological Science and Technology, Dalian University of Technology, Dalian, China.

Multi-components Traditional Chinese Medicine (TCM) treats various complex diseases (multi-etiologies and multi-symptoms) via herbs interactions to exert curative efficacy with less adverse effects. However, the ancient Chinese compatibility theory of herbs formula still remains ambiguous. Presently, this combination principle is dissected through a systems pharmacology study on the mechanism of action of a representative TCM formula, (HXZQ) prescription, on the treatment of functional dyspepsia (FD), a chronic or recurrent clinical disorder of digestive system, as typical gastrointestinal (GI) diseases which burden human physical and mental health heavily and widely. Read More

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https://www.frontiersin.org/article/10.3389/fphar.2018.01448
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http://dx.doi.org/10.3389/fphar.2018.01448DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6336928PMC
January 2019
4 Reads

Hepatic carboxylesterases are differentially regulated in PPARα-null mice treated with perfluorooctanoic acid.

Toxicology 2019 Jan 24;416:15-22. Epub 2019 Jan 24.

Department of Pharmacology and Toxicology, Rutgers University Ernest Mario School of Pharmacy, Piscataway, NJ, 08854, USA; Environmental and Occupational Health Sciences Institute, Rutgers University, Piscataway, NJ, 08854, USA; Center for Lipid Research, New Jersey Institute for Food, Nutrition, and Health, Rutgers University, New Brunswick, NJ, 08901, USA. Electronic address:

Hepatic carboxylesterases (Ces) catalyze the metabolism of drugs, environmental toxicants, and endogenous lipids and are known to be regulated by multiple nuclear receptors. Perfluorooctanoic acid (PFOA) is a synthetic fluorochemical that has been associated with dyslipidemia in exposed populations. In liver, PFOA can activate nuclear receptors such as PPARα, and alter the metabolism and excretion of chemicals. Read More

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http://dx.doi.org/10.1016/j.tox.2019.01.014DOI Listing
January 2019
3 Reads

Gracilaria dura extract confers drought tolerance in wheat by modulating abscisic acid homeostasis.

Plant Physiol Biochem 2019 Mar 16;136:143-154. Epub 2019 Jan 16.

Department of Molecular Ecology, Max Planck Institute for Chemical Ecology, Jena, Germany.

Water stress severely reduces the production of wheat. Application of seaweed extracts have started to show promise in protecting plants from environmental stresses as they contain several biostimulants. However, the modes of action of these biostimulants are not clear. Read More

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http://dx.doi.org/10.1016/j.plaphy.2019.01.015DOI Listing
March 2019
1 Read
2.756 Impact Factor

Glutathione S-transferases P1 protects breast cancer cell from adriamycin-induced cell death through promoting autophagy.

Cell Death Differ 2019 Jan 25. Epub 2019 Jan 25.

State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, 210023, China.

Glutathione S-transferases P1 (GSTP1) is a phase II detoxifying enzyme and increased expression of GSTP1 has been linked with acquired resistance to anti-cancer drugs. However, most anticancer drugs are not good substrates for GSTP1, suggesting that the contribution of GSTP1 to drug resistances might not be dependent on its capacity to detoxify chemicals or drugs. In the current study, we found a novel mechanism by which GSTP1 protects human breast cancer cells from adriamycin (ADR)-induced cell death and contributes to the drug resistance. Read More

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http://dx.doi.org/10.1038/s41418-019-0276-yDOI Listing
January 2019
2 Reads
8.184 Impact Factor

Current applications of electrospun polymeric nanofibers in cancer therapy.

Mater Sci Eng C Mater Biol Appl 2019 Apr 29;97:966-977. Epub 2018 Dec 29.

Electrospun Materials and Polymeric Membranes Research Group (EMPMRG), National Textile University, Faisalabad 37610, Pakistan.

Cancer is one of the most dangerous diseases which had been encountering the human beings since last several decades. In 2018, according to national cancer institute, about 609,640 people are expected to die from cancer and about 1,735,350 new patients are expected to be diagnosed with this lethal disease. Nanotechnology has played a significant role in almost every field of life including medical sciences. Read More

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http://dx.doi.org/10.1016/j.msec.2018.12.105DOI Listing
April 2019
1 Read

Polydopamine Modified Superparamagnetic Iron Oxide Nanoparticles as Multifunctional Nanocarrier for Targeted Prostate Cancer Treatment.

Nanomaterials (Basel) 2019 Jan 22;9(2). Epub 2019 Jan 22.

Department of Applied Chemistry, Sardar Vallabhbhai National Institute of Technology, 395007 Surat, India.

Polydopamine (pDA)-modified iron oxide core-shell nanoparticles (IONPs) are developed and designed as nanovectors of drugs. Reactive quinone of pDA enhances the binding efficiency of various biomolecules for targeted delivery. Glutathione disulfide (GSSG), an abundant thiol species in the cytoplasm, was immobilized on the pDA-IONP surface. Read More

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http://dx.doi.org/10.3390/nano9020138DOI Listing
January 2019
2 Reads

Carbamazepine, triclocarban and triclosan biodegradation and the phylotypes and functional genes associated with xenobiotic degradation in four agricultural soils.

Sci Total Environ 2019 Mar 11;657:1138-1149. Epub 2018 Dec 11.

Department of Civil and Environmental Engineering, Michigan State University, East Lansing, MI 48824, USA. Electronic address:

Pharmaceuticals and personal care products (PPCPs) are released into the environment due to their poor removal during wastewater treatment. Agricultural soils subject to irrigation with wastewater effluent and biosolids application are possible reservoirs for these chemicals. This study examined the impact of the pharmaceutical carbamazepine (CBZ), and the antimicrobial agents triclocarban (TCC) and triclosan (TCS) on four soil microbial communities using shotgun sequencing (HiSeq Illumina) with the overall aim of determining possible degraders as well as the functional genes related to general xenobiotic degradation. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00489697183499
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http://dx.doi.org/10.1016/j.scitotenv.2018.12.145DOI Listing
March 2019
3 Reads

Capecitabine-loaded nanoniosomes and evaluation of anticancer efficacy.

Artif Cells Nanomed Biotechnol 2019 Dec;47(1):420-426

a Nanomedicine and Nanobiology Research Center , Shiraz University of Medical Sciences , Shiraz , Iran.

Capecitabine (CAP) is an FDA-approved and frequently used chemotherapeutic agent for the treatment of various cancers. However, there are some side effects and chemoresistance limiting its use. Nanotechnological approaches can enhance the efficacy of anticancer drugs. Read More

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http://dx.doi.org/10.1080/21691401.2018.1559179DOI Listing
December 2019
2 Reads

Preliminary results on the uptake and biochemical response to water-exposure of Tamiflu® (oseltamivir phosphate) in two marine bivalves.

J Toxicol Environ Health A 2019 Jan 22:1-11. Epub 2019 Jan 22.

a Institute of Marine Sciences (ICM-CSIC) , Barcelona , Spain.

Tamiflu® (oseltamivir phosphate, OST) is an antiviral drug used for the pandemic treatment of avian influenza but few data are available regarding its toxicity. It should be noted that acute adverse responses are not likely to occur due to low environmental presence of this drug. Nonetheless, water concentration levels of this compound may reach the µg/L range under influenza episodes. Read More

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http://dx.doi.org/10.1080/15287394.2018.1562393DOI Listing
January 2019
2 Reads

The natural phenolic compounds as modulators of NADPH oxidases in hypertension.

Phytomedicine 2018 Aug 6;55:200-213. Epub 2018 Aug 6.

Pharmaceutical Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran; Department of Pharmacodynamics and Toxicology, School Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address:

Background: Hypertension is a major public health problem worldwide. It is an important risk factor for other cardiovascular diseases such as coronary artery disease, stroke, heart failure, atrial fibrillation, peripheral vascular disease, chronic kidney disease, and atherosclerosis.

Purpose: There is strong evidence that excess ROS-derived NADPH oxidase (NOX) is an important agent in hypertension. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09447113183026
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http://dx.doi.org/10.1016/j.phymed.2018.08.002DOI Listing
August 2018
4 Reads

INSIdE NANO: a systems biology framework to contextualize the mechanism-of-action of engineered nanomaterials.

Sci Rep 2019 Jan 17;9(1):179. Epub 2019 Jan 17.

Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland.

Engineered nanomaterials (ENMs) are widely present in our daily lives. Despite the efforts to characterize their mechanism of action in multiple species, their possible implications in human pathologies are still not fully understood. Here we performed an integrated analysis of the effects of ENMs on human health by contextualizing their transcriptional mechanism-of-action with respect to drugs, chemicals and diseases. Read More

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http://dx.doi.org/10.1038/s41598-018-37411-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6336851PMC
January 2019
1 Read

Alleviation of Drugs and Chemicals Toxicity: Biomedical Value of Antioxidants.

Oxid Med Cell Longev 2018 17;2018:6276438. Epub 2018 Dec 17.

All India Institute of Medical Sciences, Department of Biochemistry, Bhopal, Madhya Pradesh, India.

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http://dx.doi.org/10.1155/2018/6276438DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311870PMC
December 2018
2 Reads

GPR17 receptor modulators and their therapeutic implications: review of recent patents.

Expert Opin Ther Pat 2019 Feb 24;29(2):85-95. Epub 2019 Jan 24.

a School of Pharmacy, Medicinal Chemistry Unit , University of Camerino , Camerino , Italy.

Introduction: The GPR17 receptor, phylogenetically related to both purinergic P2Y and CysLT receptors, is mainly expressed in the CNS and, in general, in organs that can typically undergo ischemic damage. This receptor is involved in various pathologies including stroke, brain and spinal cord trauma, multiple sclerosis and in all diseases characterized by neuronal and myelin dysfunction. Therefore, there is a strong needed to identify molecules capable of binding specifically to GPR17 receptors. Read More

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http://dx.doi.org/10.1080/13543776.2019.1568990DOI Listing
February 2019
2 Reads

Mifepristone affects fertility and development in the sea urchin Paracentrotus lividus.

Mol Reprod Dev 2019 Jan 13. Epub 2019 Jan 13.

Department of Sciences and Technology, University of Sannio, Benevento, Italy.

Drugs such as oral contraceptives and hormone replacement therapies are known to find their way into rivers, lakes and seas, and have the potential to affect reproduction and development of the wildlife. The knowledge of the reproductive mechanisms and their regulation in aquatic species is of fundamental importance for predicting and preventing the damage by the increasing release of such chemicals in the environment. Mifepristone, a synthetic steroid used as a drug for chemical abortion, works by blocking the effects of progesterone. Read More

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http://dx.doi.org/10.1002/mrd.23112DOI Listing
January 2019
7 Reads

Induction of Apoptosis in Metastatic Breast Cancer Cells: XV. Downregulation of DNA Polymerase-α - Helicase Complex (Replisomes) and Glyco-Genes.

Adv Exp Med Biol 2018 ;1112:199-221

ICGEB, New Delhi, India.

In normal and cancer cells, successful cell division requires accurate duplication of chromosomal DNA. All cells require a multiprotein DNA duplication system (replisomes) for their existence. However, death of normal cells in our body occurs through the apoptotic process. Read More

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http://dx.doi.org/10.1007/978-981-13-3065-0_15DOI Listing
January 2018
3 Reads

Aliphatic Halogenated Hydrocarbons: Report and Analysis of Liver Injury in 60 Patients.

Authors:
Rolf Teschke

J Clin Transl Hepatol 2018 Dec 16;6(4):350-361. Epub 2018 Nov 16.

Department of Internal Medicine II, Division of Gastroenterology and Hepatology, Klinikum Hanau, Hanau, Academic Teaching Hospital of the Medical Faculty, Goethe University Frankfurt/Main, Frankfurt/Main, Germany.

Intoxications by aliphatic halogenated hydrocarbons (AHH), used as effective solvents, are rare and may cause life-threatening liver injury. Patients with acute intoxications by AHH received an innovative treatment. Analyzed were data of 60 patients intoxicated by AHH, such as dichloromethane ( = 3), chloroform ( = 2), carbon tetrachloride ( = 12), 1,2-dichloroethane ( = 18), 1,1,2-trichloroethane ( = 2), trichloroethylene ( = 2), tetrachloroethylene ( = 13) or mixed AHH chemicals ( = 8), who received a new treatment consisting of CO-induced hyperventilation to accelerate toxin removal via the lungs. Read More

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http://www.xiahepublishing.com/2310-8819/ArticleFullText.asp
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http://dx.doi.org/10.14218/JCTH.2018.00040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6328725PMC
December 2018
4 Reads

The search for the "next" euphoric non-fentanil novel synthetic opioids on the illicit drugs market: current status and horizon scanning.

Forensic Toxicol 2019 28;37(1):1-16. Epub 2018 Nov 28.

4Forensic Drug Research Group, Centre for Anatomy and Human Identification, School of Science and Engineering, University of Dundee, Dundee, UK.

Purpose: A detailed review on the chemistry and pharmacology of non-fentanil novel synthetic opioid receptor agonists, particularly -substituted benzamides and acetamides (known colloquially as U-drugs) and 4-aminocyclohexanols, developed at the Upjohn Company in the 1970s and 1980s is presented.

Method: Peer-reviewed literature, patents, professional literature, data from international early warning systems and drug user fora discussion threads have been used to track their emergence as substances of abuse.

Results: In terms of impact on drug markets, prevalence and harm, the most significant compound of this class to date has been U-47700 (-3,4-dichloro--[2-(dimethylamino)cyclohexyl]--methylbenzamide), reported by users to give short-lasting euphoric effects and a desire to re-dose. Read More

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http://dx.doi.org/10.1007/s11419-018-0454-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6314991PMC
November 2018
1 Read

Predictive Value of Cellular Accumulation of Hydrophobic Bile Acids as a Marker of Cholestatic Drug Potential.

Toxicol Sci 2019 Jan 10. Epub 2019 Jan 10.

INSERM U1241, Numecan, Rennes.

Drug-induced cholestasis is mostly intrahepatic and characterized by alterations of bile canaliculi dynamics and morphology as well as accumulation of bile acids (BAs) in hepatocytes. However, little information exists on first changes in BA content and profile induced by cholestatic drugs in human liver. In the present study we aimed to analyze the effects of a large set of cholestatic and noncholestatic drugs in presence of physiological serum concentrations and 60-fold higher levels of 9 main BAs on cellular accumulation of BAs using HepaRG hepatocytes. Read More

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http://dx.doi.org/10.1093/toxsci/kfz009DOI Listing
January 2019
2 Reads

Influence of anthropogenic activities and risk assessment on protected mangrove forest using traditional and emerging molecular markers (Ceará coast, northeastern Brazil).

Sci Total Environ 2019 Mar 30;656:877-888. Epub 2018 Nov 30.

Instituto de Ciências do Mar, Universidade Federal do Ceará, Av. Abolição, 3207, 60165-081 Fortaleza, CE, Brazil. Electronic address:

Anthropogenic molecular markers were used to assess chemicals inputs and ecological risks associated from multiple sources to sediments in one of the largest tropical mangrove forests of South America, with a particular focus on lesser studied compounds resulting from rural activities. Total concentrations ranged from 23.4 to 228. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2018.11.380DOI Listing
March 2019
3 Reads

Initial Assessment of Variability of Responses to Toxicants in Donor-Specific Endothelial Colony Forming Cells.

Front Public Health 2018 21;6:369. Epub 2018 Dec 21.

Creative Scientist, Inc. Durham, NC, United States.

There is increased interest in using high throughput assays to characterize human population variability in response to toxicants and drugs. Utilizing primary human endothelial colony-forming cells (ECFCs) isolated from blood would be highly useful for this purpose because these cells are involved in neonatal and adult vasculogenesis. We characterized the cytotoxicity of four known toxic chemicals (NaAsO, CdCl, tributyltin [TBT], and menadione) and their four relatively nontoxic counterparts (NaHAsO, ZnCl, SnCl, and phytonadione, respectively) in eight ECFC clones representing four neonatal donors (2 male and 2 female donors, 2 clones per donor). Read More

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https://www.frontiersin.org/article/10.3389/fpubh.2018.00369
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http://dx.doi.org/10.3389/fpubh.2018.00369DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6308159PMC
December 2018
5 Reads

eToxPred: a machine learning-based approach to estimate the toxicity of drug candidates.

BMC Pharmacol Toxicol 2019 Jan 8;20(1). Epub 2019 Jan 8.

Department of Biological Sciences, Louisiana State University, Baton Rouge, LA, 70803, USA.

Background: The efficiency of drug development defined as a number of successfully launched new pharmaceuticals normalized by financial investments has significantly declined. Nonetheless, recent advances in high-throughput experimental techniques and computational modeling promise reductions in the costs and development times required to bring new drugs to market. The prediction of toxicity of drug candidates is one of the important components of modern drug discovery. Read More

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http://dx.doi.org/10.1186/s40360-018-0282-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6325674PMC
January 2019
2 Reads

The Utility of Zebrafish as a Model for Screening Developmental Neurotoxicity.

Front Neurosci 2018 18;12:976. Epub 2018 Dec 18.

Nano Carbon Materials, Center for Sustainable Future Technologies, Istituto Italiano di Tecnologia, Turin, Italy.

The developing central nervous system and the blood brain barrier are especially vulnerable and sensitive to different chemicals, including environmental contaminants and drugs. Developmental exposure to these compounds has been involved in several neurological disorders, such as autism spectrum disorders as well as Alzheimer's and Parkinson's diseases. Zebrafish () have emerged as powerful toxicological model systems that can speed up chemical hazard assessment and can be used to extrapolate neurotoxic effects that chemicals have on humans. Read More

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http://dx.doi.org/10.3389/fnins.2018.00976DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6305331PMC
December 2018
1 Read

Reduction-responsive shell cross-linked micelles derived from amphiphilic triblock copolymer as anticancer drug delivery carrier.

Mater Sci Eng C Mater Biol Appl 2019 Mar 15;96:383-390. Epub 2018 Nov 15.

Institute of Materials Research and Engineering, A*STAR (Agency for Science, Technology and Research), 2 Fusionopolis Way, Innovis, #08-03, Singapore 138634, Singapore. Electronic address:

Stimuli-responsive crosslinked micelles are attractive carriers for in vivo delivery of water-insoluble therapeutic drugs due to their excellent stability during the blood circulation and high therapeutic effect resulting from the intelligent break-up of the crosslinked structure triggered by intracellular conditions as well as the subsequent fast drug release. Herein, novel amphiphilic triblock copolymer poly(l-lactide)-b-poly(allyl glycidyl ether/propanedithiol)-b-poly(ethylene glycol) (PLLA-b-P(AGE-SH)-b-PEG) was designed and synthesized by combining two successive ring-opening polymerizations and subsequent "thio-ene" reaction. Due to their unique amphiphilic architecture, copolymer PLLA-b-P(AGE-SH)-b-PEG could self-assemble into core-shell micelles, and the stimuli-responsive crosslinked micelles (SCMs) were obtained by crosslinking the P(AGE-SH) segments in the micellar shell under redox condition. Read More

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http://dx.doi.org/10.1016/j.msec.2018.11.015DOI Listing
March 2019
1 Read

Screening The Pathogen Box for Identification of New Chemicals Agents With Anti Activity.

Antimicrob Agents Chemother 2019 Jan 2. Epub 2019 Jan 2.

Department of Medicine (Infectious Diseases), Stony Brook University, Stony Brook, New York, USA; Department of Microbiology and Molecular Genetics, Stony Brook University, Stony Brook, New York, USA; Global Health Institute, Stony Brook University, Stony Brook, New York, USA.

Fascioliasis is an infectious parasitic disease distributed globally and caused by the liver flukes or This neglected tropical disease affects both animals and humans and it represents a latent public health problem due to the significant economic losses related to animal husbandry. For decades, Triclabendazole has been the unique anti-Fasciola drug that can effectively treat this disease. However, triclabendazole resistance in Fascioliasis has been more recently reported around the world, and thus the discovery of novel drugs is an urgent need. Read More

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http://dx.doi.org/10.1128/AAC.02373-18DOI Listing
January 2019
2 Reads

Paper Analytic Device to Detect the Presence of Four Chemotherapy Drugs.

J Glob Oncol 2018 Dec(4):1-10

Madeline Smith and Marya Lieberman, University of Notre Dame, Notre Dame, IN; and Ayenew Ashenef, Addis Ababa University, Addis Ababa, Ethiopia.

A paper analytic device, the chemoPAD, was developed and validated to visually detect methotrexate, doxorubicin, cisplatin, and oxaliplatin at concentrations commonly found in injectable dosage forms. By testing residual solution after patient treatment, the chemoPAD can be used to monitor drug quality without restriction of patient access to medication. The chemoPAD is produced by wax printing on Ahlstrom paper to create separate reaction areas and deposits small amounts of chemicals to create color changes in response to different active pharmaceutical ingredients (APIs). Read More

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http://dx.doi.org/10.1200/JGO.18.00198DOI Listing
December 2018
2 Reads