1,431,109 results match your criteria Drugs & aging[Journal]


Legal and ethical implications of defining an optimum means of achieving unconsciousness in assisted dying.

Anaesthesia 2019 Feb 20. Epub 2019 Feb 20.

Nuffield Department of Anaesthetics, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.

A decision by a society to sanction assisted dying in any form should logically go hand-in-hand with defining the acceptable method(s). Assisted dying is legal in several countries and we have reviewed the methods commonly used, contrasting these with an analysis of capital punishment in the USA. We expected that, since a common humane aim is to achieve unconsciousness at the point of death, which then occurs rapidly without pain or distress, there might be a single technique being used. Read More

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http://dx.doi.org/10.1111/anae.14532DOI Listing
February 2019

Pethidine in Low Doses versus Dipyrone for Pain Relief in Labor: A Randomized Controlled Trial.

Rev Bras Ginecol Obstet 2019 Feb 20;41(2):84-89. Epub 2019 Feb 20.

Graduate Program in Medical Sciences, Universidade de Fortaleza, Fortaleza, CE, Brazil.

Objective:  To compare low doses of pethidine with dipyrone in labor analgesia.

Methods:  In a randomized prospective study conducted by Universidade de Fortaleza, in the state of Ceará, Brazil, between May and December 2016, 200 full-term parturients, with very painful uterine contractions and exhibiting uterine cervix dilatation ≥ 5 cm, were selected to receive a single intravenous dose of either 0.25 mg/kg of pethidine ( = 100) or of 25 mg/kg of dipyrone ( = 100). Read More

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http://dx.doi.org/10.1055/s-0038-1676509DOI Listing
February 2019

Cholinergic drugs ameliorate endothelial dysfunction by decreasing O-GlcNAcylation via M3 AChR-AMPK-ER stress signaling.

Life Sci 2019 Feb 17. Epub 2019 Feb 17.

Department of Pharmacology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi 710061, People's Republic of China. Electronic address:

Aims: Obesity is associated with increased cardiovascular morbidity and mortality. It is accompanied by augmented O-linked β-N-acetylglucosamine (O-GlcNAc) modification of proteins via increasing hexosamine biosynthetic pathway (HBP) flux. However, the changes and regulation of the O-GlcNAc levels induced by obesity are unclear. Read More

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http://dx.doi.org/10.1016/j.lfs.2019.02.036DOI Listing
February 2019

History of Psychopharmacology.

Annu Rev Clin Psychol 2019 Feb 20. Epub 2019 Feb 20.

Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, University of California, Los Angeles, California 90095-1759, USA; email:

We live in an age of psychopharmacology. One in six persons currently takes a psychotropic drug. These drugs have profoundly shaped our scientific and cultural understanding of psychiatric disease. Read More

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http://dx.doi.org/10.1146/annurev-clinpsy-050718-095514DOI Listing
February 2019

Wearable Sensors for Biochemical Sweat Analysis.

Annu Rev Anal Chem (Palo Alto Calif) 2019 Feb 20. Epub 2019 Feb 20.

Department of Materials Science and Engineering, Northwestern University, Evanston, Illinois 60208, USA; email:

Sweat is a largely unexplored biofluid that contains many important biomarkers ranging from electrolytes and metabolites to proteins, cytokines, antigens, and exogenous drugs. The eccrine and apocrine glands produce and excrete sweat through microscale pores on the epidermal surface, offering a noninvasive means for capturing and probing biomarkers, which reflect hydration state, fatigue, nutrition, and physiological changes. Skin-interfaced wearable sensors capable of real-time in situ sweat collection and analytics provide capabilities for continuous biochemical monitoring in an ambulatory mode of operation. Read More

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http://dx.doi.org/10.1146/annurev-anchem-061318-114910DOI Listing
February 2019

High Throughput Complementary Analysis and Quantitation of Metabolites by MALDI- and Silicon Nanopost Array-Laser Desorption Ionization Mass Spectrometry.

Anal Chem 2019 Feb 20. Epub 2019 Feb 20.

Silicon nanopost arrays (NAPA) have been shown to be effective substrates for laser desorption ionization-mass spectrometry (LDI-MS), and have been used to analyze a variety of samples including peptides, metabolites, drugs, explosives, and intact cells, as well as to image lipids and metabolites in tissue sections. However, no direct comparison has yet been conducted between NAPA-MS and the most commonly-used LDI-MS technique, matrix-assisted laser desorption ionization (MALDI)-MS. In this work, we compare the utility of NAPA-MS to that of MALDI-MS using two common matrices for the analysis of metabolites in cellular extracts and human urine. Read More

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http://dx.doi.org/10.1021/acs.analchem.8b05074DOI Listing
February 2019

DUckCov: a Dynamic Undocking-based Virtual Screening Protocol for Covalent Binders.

ChemMedChem 2019 Feb 20. Epub 2019 Feb 20.

Research Center for Natural Sciences, Medicinal Chemistry, Magyar tudosok krt 2, H-1117, Budapest, HUNGARY.

Thanks to recent guidelines, the design of safe and effective covalent drugs has gained significant interest. Other than targeting non-conserved nucleophilic residues, optimizing the non-covalent binding framework is important to improve potency and selectivity of covalent binders towards the desired target. Strong efforts have been made in extending the computational toolkits to include a covalent mechanism of protein targeting, like in the development of covalent docking methods for binding mode prediction. Read More

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http://dx.doi.org/10.1002/cmdc.201900078DOI Listing
February 2019
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High quality process of care increases one-year survival after acute myocardial infarction (AMI): A cohort study in Italy.

PLoS One 2019 20;14(2):e0212398. Epub 2019 Feb 20.

Department of Epidemiology of Lazio Regional Health Service, Rome, Italy.

Background: The relationship between guideline adherence and outcomes in patients with acute myocardial infarction (AMI) has been widely investigated considering the emergency, acute, post-acute phases separately, but the effectiveness of the whole care process is not known.

Aim: The study aim was to evaluate the effect of the multicomponent continuum of care on 1-year survival after AMI.

Methods: We conducted a cohort study selecting all incident cases of AMI from health information systems during 2011-2014 in the Lazio region. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212398PLOS
February 2019

Metal based donepezil analogues designed to inhibit human acetylcholinesterase for Alzheimer's disease.

PLoS One 2019 20;14(2):e0211935. Epub 2019 Feb 20.

Division of Computer-Aided Drug Design, The Red-Green Research Centre, Dhaka, Bangladesh.

Among neurodegenerative disorders, Alzheimer's disease (AD) is one of the most common disorders showing slow progressive cognitive decline. Targeting acetylcholinesterase (AChE) is one of the major strategies for AD therapeutics, as cholinergic pathways in the cerebral cortex and basal forebrain are compromised. Herein, we report the design of some copper and other metal based donepezil derivatives, employing density functional theory (DFT). Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0211935PLOS
February 2019

Access to and price trends of antidiabetic, antihypertensive, and antilipidemic drugs in outpatient settings of the Universal Coverage Scheme in Thailand.

PLoS One 2019 20;14(2):e0211759. Epub 2019 Feb 20.

Department of Clinical Pharmacy, Faculty of Pharmacy, Mahasarakham University, Mahasarakham, Thailand.

Under the Universal Coverage Scheme (UCS) with payment per capita for outpatient (OP) services, hospitals' financial risks will rise if access to essential drugs increases. This study examined trends in access to and price of essential drugs for noncommunicable diseases (NCDs) and an overall purchasing price index (PPI) for an OP drug basket from public hospitals. To examine drug access, OP prescription data from 2010-2012 were obtained from the UCS. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0211759PLOS
February 2019
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Impact of Farnesol as a Modulator of Efflux Pumps in a Fluconazole-Resistant Strain of Candida albicans.

Microb Drug Resist 2019 Feb 20. Epub 2019 Feb 20.

1 Department of Microbiology and Virology, Faculty of Natural Sciences, Comenius University in Bratislava, Bratislava, Slovakia.

Aim: This work studied the impact of the quorum-sensing molecule, farnesol (FAR), on fluconazole (FLC)-resistant Candida albicans isolate CY 1123 compared with the susceptible standard strain C. albicans SC5314. The genes encoding efflux pumps belonging to the ATP-binding cassette (ABC) and major facilitator superfamilies, together with overexpression or point mutation of the ERG11 gene, are the main resistance mechanisms to azole antifungal drugs. Read More

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http://dx.doi.org/10.1089/mdr.2017.0332DOI Listing
February 2019

Robustness of the Line Probe Assay for the Rapid Diagnosis and Characterization of Mutations in Extensively Drug-Resistant Tuberculosis.

Microb Drug Resist 2019 Feb 20. Epub 2019 Feb 20.

4 Department of Microbiology, CMC Vellore, Vellore, Tamil Nadu, India.

Introduction: Extensively drug-resistant tuberculosis (XDRTB) is a public health concern. We evaluated the diagnostic accuracy of Genotype MTBDRsl for detection of resistance to fluoroquinolones (FQs) and second-line injectable drugs (SLIDs) and characterized mutations seen.

Materials And Methods: MTBDRsl was carried out either directly on sputum samples or indirectly on culture isolates (n = 100) from known multidrug-resistant tuberculosis (MDRTB) patients from July 2015 to September 2017. Read More

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http://dx.doi.org/10.1089/mdr.2018.0268DOI Listing
February 2019

Methylsulfonylated Polyketides Produced by Neosartorya udagawae HDN13-313 via Exogenous Addition of Small Molecules.

J Nat Prod 2019 Feb 20. Epub 2019 Feb 20.

Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy , Ocean University of China , Qingdao 266003 , People's Republic of China.

Two new polyketides modified with a rare methylsulfonyl group, 3-methoxy-6-methyl-5-(methylsulfonyl)benzene-1,2,4-triol (1) and neosartoryone A (2), along with a biogenetically related compound (3), were isolated from Neosartorya udagawae HDN13-313 cultivated with the DNA methyltransferase inhibitor 5-azacytidine. The methylsulfonyl group of 1 and 2 was proven to be derived from DMSO, which was used as the solvent to dissolve 5-azacytidine. This is the first report of a fungus that can achieve a sulfonylation-like modification of natural products utilizing DMSO as a sulfur source. Read More

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http://dx.doi.org/10.1021/acs.jnatprod.9b00035DOI Listing
February 2019

N-Heterocyclic Carbene-Catalyzed Decarboxylative Alkylation of Aldehydes.

J Am Chem Soc 2019 Feb 20. Epub 2019 Feb 20.

We found that N-heterocyclic carbene catal- ysis promoted the unprecedented decarboxylative coupling of aryl aldehydes and tertiary or secondary alkyl carboxylic acid-derived redox-active esters to produce aryl alkyl ke- tones. The mild and transition-metal-free reaction condi- tions are attractive features of this method. The power of this protocol was demonstrated by the functionalization of pharmaceutical drugs and natural product. Read More

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http://dx.doi.org/10.1021/jacs.9b00880DOI Listing
February 2019

[Renal risks of NSAIDs in endurance sports].

Rev Med Suisse 2019 Feb;15(639):444-447

Faculté de médecine, Université de Genève, 1205 Genève 4.

Endurance athletes, either professional or amateur, are consuming non steroidal anti-inflammatory drugs (NSAIDs) during their training and races. The goal is to decrease pain or to prevent a potential pain. These athletes, especially, the amateurs, do not do not know the side effects and have no medical supervision. Read More

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February 2019

Microscopic alterations in Fasciola hepatica from sheep treated with albendazole.

Rev Bras Parasitol Vet 2019 Feb 14. Epub 2019 Feb 14.

Departamento de Parasitologia Animal, Instituto de Veterinária, Universidade Federal Rural do Rio de Janeiro - UFRRJ, Seropédica, RJ, Brasil.

Currently, albendazole is one of the most commonly used drugs because of its affordability. The objective was to evaluate the histopathology of Fasciola hepatica specimens. For this, the efficacy test was performed on sheep treated with albendazole at the dose recommended for F. Read More

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http://dx.doi.org/10.1590/S1984-296120180095DOI Listing
February 2019

WAITING DAAS LIST MORTALITY IMPACT IN HCV CIRRHOTIC PATIENTS.

Arq Gastroenterol 2018 Oct-Dec;55(4):343-345

Universidade Estadual Paulista (UNESP), Faculdade de Medicina, Departamento de Clínica Médica, Botucatu, SP, Brasil.

Background: The infection for the hepatitis C virus (HCV) is a leading cause of liver-related morbidity and mortality through its evolution to liver cirrhosis, end-stage liver complications and hepatocellular carcinoma. Currently, the new drugs for the HCV infection, based on direct antiviral agents, have changed the outcomes in this setting.

Objective: To assess death incidence, during the wait for the treatment with the new drugs, and to analyze which independent variable (age, sex, ascite, HDA, albumin, α-fetoprotein, platelets and Meld score) had relation with death. Read More

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S
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http://dx.doi.org/10.1590/S0004-2803.201800000-76DOI Listing
May 2018
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The effect of hirudin on antagonisting thrombin induced apoptosis of human microvascular endothelial cells1.

Acta Cir Bras 2019 Feb 14;34(1):e20190010000006. Epub 2019 Feb 14.

MD, Department of Plastic and Aesthetic Surgery, The First Affiliated Hospital of Guangxi Medical University, China. Analysis and interpretation of data, critical revision.

Purpose: To investigate whether hirudin exerts its antithrombin action to decrease the ratio of Human Microvascular Endothelial Cells (HMVECs) apoptosis.

Methods: Human microvascular endothelial cells (HMVECs) cultured in the third and fifth generations were used. HMVECs were divided into normal group, thrombin group (T group), natrual hirudin group (H group), thrombin + natrual hirudin group (T + H group), AG490 group, thrombin + AG490 group (T + AG490 group), natrual hirudin + AG490 group (H + AG490 group), thrombin + natural hirudin + AG490 (T + H + AG490 group). Read More

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http://dx.doi.org/10.1590/s0102-865020190010000006DOI Listing
February 2019

Risk factors associated with in-hospital falls reported to the Patient Safety Commitee of a teaching hospital.

Einstein (Sao Paulo) 2019 Feb 14;17(1):eAO4432. Epub 2019 Feb 14.

Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.

Objective: To investigate the use of fall-risk-increasing drugs among patients with falls reported to the Patient Safety Office of a hospital, and to identify the factors associated with high risk for fall.

Methods: A cross-sectional study, carried out in a teaching hospital. The study population was the universe of fall reports received by the Patient Safety Office. Read More

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http://dx.doi.org/10.31744/einstein_journal/2019AO4432DOI Listing
February 2019

Outpatient Parenteral Antimicrobial Therapy in Vulnerable Populations-- People Who Inject Drugs and the Homeless.

J Hosp Med 2019 Feb;14(2):105-109

Harborview Medical Center, Seattle, Washington, USA.

Outpatient parenteral antimicrobial therapy (OPAT) programs can provide high-value care but may be challenging in people who inject drugs (PWID) and homeless individuals. We conducted a single-center, retrospective, cohort study of adults who received OPAT at an urban, public health hospital from January 1, 2015 to April 30, 2016, grouped by PWID and housing status. Outcomes included clinical cure, length of stay, secondary bacteremia, line-tampering, and readmission. Read More

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http://dx.doi.org/10.12788/jhm.3138DOI Listing
February 2019

Cellular Senescence in the Lung Across the Age Spectrum.

Am J Physiol Lung Cell Mol Physiol 2019 Feb 20. Epub 2019 Feb 20.

Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, United States.

Cellular senescence results in cell cycle arrest with secretion of cytokines, chemokines, growth factors and remodeling proteins (senescence associated secretory phenotype; SASP) that have autocrine and paracrine effects on the tissue microenvironment. SASP can promote remodeling, inflammation, infectious susceptibility, angiogenesis and proliferation, while hindering tissue repair and regeneration. While the role of senescence and contributions of senescent cells are increasingly recognized in the context of aging and a variety of disease states, relatively less is known regarding the portfolio and influences of senescent cells in normal lung growth and aging per se, or in the induction or progression of lung diseases across the age spectrum such as bronchopulmonary dysplasia, asthma, COPD, or pulmonary fibrosis. Read More

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http://dx.doi.org/10.1152/ajplung.00424.2018DOI Listing
February 2019

The pharmacologic management of multiple myeloma in older adults.

Expert Opin Pharmacother 2019 Feb 20:1-16. Epub 2019 Feb 20.

d Department of Medicine, Division of Hematology and Oncology , Case Western Reserve University , Cleveland , OH , USA.

Introduction: Multiple myeloma is a disease predominately affecting older adults. Pivotal to treating older adults is understanding their physiologic differences compared to younger subjects and how the complexity of therapies has an impact upon this patient population. Areas covered: Herein, the authors address the efficacy of chemotherapy regimens, decision-making for older adults, chemotherapy-associated toxicity and the approach to management. Read More

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http://dx.doi.org/10.1080/14656566.2019.1577822DOI Listing
February 2019

Synthesis of Rosmarinic Acid Amides as Antioxidative and Hypoglycemic Agents.

J Nat Prod 2019 Feb 20. Epub 2019 Feb 20.

Type 2 diabetes mellitus (T2DM) is an important metabolic disorder for which there is an urgent need for new antidiabetic drugs. α-Glucosidase inhibition is an established protocol for T2DM therapy. Because hyperglycemia causes oxidative tissue damage, the development of agents with both α-glucosidase inhibition and antioxidant activity from natural or natural-derived polyphenols such derivatives of rosmarinic acid (RA) represents an attractive therapeutic option. Read More

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http://dx.doi.org/10.1021/acs.jnatprod.8b01002DOI Listing
February 2019

Structure-based In Silico Screening Identifies a Potent Ebolavirus Inhibitor from a Traditional Chinese Medicine Library.

J Med Chem 2019 Feb 20. Epub 2019 Feb 20.

Potent Ebolavirus (EBOV) inhibitors will help to curtail outbreaks such as that which occurred in 2014-16 in West Africa. EBOV has on its surface a single glycoprotein (GP) critical for viral entry and membrane fusion. Recent high resolution complexes of EBOV GP with a variety of approved drugs revealed that binding to a common cavity prevented fusion of the virus and endosomal membranes, inhibiting virus infection. Read More

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http://dx.doi.org/10.1021/acs.jmedchem.8b01328DOI Listing
February 2019

[Tension type headache and its treatment possibilities].

Ideggyogy Sz 2019 Jan;72(1-2):13-21

Semmelweis Egyetem, ÁOK, Neurológiai Klinika, Budapest.

Tension type headache, the most common type of primary headaches, affects approximately 80% of the population. Mainly because of its high prevalence, the socio-economic consequences of tension type headache are significant. The pain in tension type headache is usually bilateral, mild to moderate, is of a pressing or tightening quality, and is not accompanied by other symptoms. Read More

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http://dx.doi.org/10.18071/https://doi.org/10.18071/isz.72.0013DOI Listing
January 2019

A scoping review of harm reduction training for police officers.

Drug Alcohol Rev 2019 Feb;38(2):131-150

Dalla Lana School of Public Health, University of Toronto, Toronto, Canada.

Issues: Preventable overdose deaths, especially due to opioids, have increasingly been reported worldwide. Expansion of life-saving harm reduction services is underway with increasing public support in some jurisdictions. However, such services often fall short of reaching people who use drugs (PWUD), in part, due to law enforcement practices that are aligned with punitive drug laws and incongruent with harm reduction principles. Read More

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http://dx.doi.org/10.1111/dar.12904DOI Listing
February 2019

Italian expert panel consensus statements on two-drug antiretroviral regimens to treat naïve and virologically suppressed HIV-1 infected patients.

New Microbiol 2019 Feb 20;42(1). Epub 2019 Feb 20.

Infectious Diseases, University of "Rome "Tor Vergata". Rome, Italy.

New strategies for HIV treatment able to reduce drug-exposure, medium-long term toxicities and costs are a recognized clinical need. The availability of newer drugs with improved potency and tolerability, as well as high genetic barrier to resistance, makes antiretroviral-sparing strategies with two-drug regimens (2DRs) particularly attractive. Substantial evidence has been generated over the last few years supporting 2DR in virologically suppressed HIV infected patients for whom a therapy switch is planned. Read More

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February 2019

Effective imprinting of an anticancer drug, 6-thioguanine, via mussel-inspired self-polymerization of dopamine over reduced graphene oxide.

Analyst 2019 Feb 20. Epub 2019 Feb 20.

Department of Chemistry, Kwangwoon University, Wolgye-Dong, Nowon-Gu, Seoul, 139-701, Korea.

Apart from being a vital catecholamine molecule responsible for the proper functioning of the central nervous system (CNS), hormonal and renal systems, dopamine (DA) has also been increasingly employed as a functional monomer in the fabrication of surface molecular imprinting polymers (MIPs) for valuable analytes. Herein, we demonstrate the effective imprinting of 6-thioguanine (6-TG), an anticancer drug, via mussel-inspired self-polymerization of dopamine conducted in a weakly alkaline solution over reduced graphene oxide (rGO). The polymerization of 6-TG resulted into a thin polydopamine (PDA) film of 8. Read More

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http://dx.doi.org/10.1039/c8an02348dDOI Listing
February 2019

Dasatinib significantly reduced in vivo exposure to cyclosporine in a rat model: The possible involvement of CYP3A induction.

Pharmacol Rep 2018 Oct 31;71(2):201-205. Epub 2018 Oct 31.

Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.

Background: This study was designed to investigate the effects of dasatinib and nilotinib on the pharmacokinetics of cyclosporine in rats, as these drugs have been reported to be cytochrome P450 3A4 (CYP3A4) substrates.

Methods: Control and test groups (n = 5) were treated with vehicle and dasatinib (4 mg/kg, and 16 mg/kg, oral) or nilotinib (94 mg/kg, oral), respectively, for 8 consecutive days. On day 8, all groups were administered cyclosporine (30 mg/kg) 1 h after the last dose of dasatinib or nilotinib. Read More

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http://dx.doi.org/10.1016/j.pharep.2018.10.018DOI Listing
October 2018

Factors associated with seizure-related motor vehicle accidents among patients with epilepsy in West China.

Seizure 2019 Jan 30;66:42-46. Epub 2019 Jan 30.

Department of Neurology, West China Hospital, Sichuan University, No. 37 Guoxue Road, Chengdu, Sichuan, 610041, People's Republic of China. Electronic address:

Purpose: This study was conducted to investigate the relevant demographics and clinical factors contributing to seizure-related motor vehicle accidents in west China.

Methods: All driving patients who visited our epilepsy clinic in the West China Hospital, between October 2012 and October 2016, were invited to participate. Data on social demographics, clinical features, and motor vehicle accidents were collected during structured interviews. Read More

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http://dx.doi.org/10.1016/j.seizure.2019.01.028DOI Listing
January 2019

Development of unstable resistance to diminazene aceturate in Babesia bovis.

Int J Parasitol Drugs Drug Resist 2019 Feb 13;9:87-92. Epub 2019 Feb 13.

National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Inada-cho, Obihiro, Hokkaido, 080-8555, Japan. Electronic address:

Diminazene aceturate (DA) is commonly used in the treatment of bovine babesiosis caused by Babesia bovis. In this study, we attempted to develop resistance in B. bovis in vitro to DA and clofazimine (CF, a novel antibabesial agent) using short- and long-term drug pressures. Read More

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http://dx.doi.org/10.1016/j.ijpddr.2019.02.001DOI Listing
February 2019

Chondroitin sulfate-functionalized polymeric nanoparticles for colon cancer-targeted chemotherapy.

Colloids Surf B Biointerfaces 2019 Feb 16;177:399-406. Epub 2019 Feb 16.

Education Ministry Key Laboratory on Luminescence and Real-Time Analysis, School of Materials and Energy, Southwest University, Chongqing, 400715, PR China; Chongqing Key Laboratory of Soft-Matter Material Chemistry and Function Manufacturing, Southwest University, Chongqing, 400715, PR China. Electronic address:

Targeted delivery of chemotherapeutic drugs to tumors is a major challenge in colon cancer chemotherapy. To overcome this bottleneck, we loaded camptothecin (CPT) into polymeric nanoparticles (NPs), and further functionalized their surface with chondroitin sulfate (CS). The resulting CS-CPT-NPs had a desirable hydrodynamic diameter (289 nm), narrow particle size distribution (polydispersity index = 0. Read More

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http://dx.doi.org/10.1016/j.colsurfb.2019.02.031DOI Listing
February 2019

Treatment patterns, clinical outcomes, health resource utilization, and cost in patients with BRCA-mutated metastatic breast cancer treated in community oncology settings.

Cancer Treat Res Commun 2019 Feb 6;19:100121. Epub 2019 Feb 6.

West Cancer Center, 7945 Wolf River Boulevard, Germantown, TN 38138, United States.

Purpose: This retrospective study of community oncology patients with breast cancer gene (BRCA)-mutated metastatic breast cancer (MBC) examined treatment outcomes and health resource utilization (HRU) and costs for a sample of patients with human epidermal growth factor receptor 2 (HER2)-negative disease who were either hormone receptor positive (HR+) or triple negative breast cancer (TNBC).

Methods: Evidence from the Vector Oncology Data Warehouse, a repository of electronic medical records/billing data and provider notes, was analyzed. Treatment outcomes were progression-free survival (PFS) and overall survival (OS) from start of first-line therapy in the metastatic setting. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S24682942183013
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http://dx.doi.org/10.1016/j.ctarc.2019.100121DOI Listing
February 2019
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Simultaneous voltammetric determination of acetaminophen and isoniazid using MXene modified screen-printed electrode.

Biosens Bioelectron 2019 Jan 29;130:315-321. Epub 2019 Jan 29.

Key Laboratory of Xinjiang Phytomedicine Resources and Utilization, Ministry of Education, School of Pharmacy, Shihezi University, Shihezi 832000, China; College of Science, Harbin Institute of Technology, Shenzhen 518055, China. Electronic address:

Determination of hepatotoxic drugs is critical for both clinical diagnosis and quantity control of their pharmaceutical formulations. In this work, a facile and sensitive sensor based on MXene modified screen-printed electrode (MXene/SPE) has been developed for detection of acetaminophen (ACOP) and isoniazid (INZ), which are two commonly used drugs but might induce liver damage in certain circumstances. MXene showed excellent electrocatalytic activity toward the oxidation of ACOP and INZ compared with bare SPE in 0. Read More

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http://dx.doi.org/10.1016/j.bios.2019.01.043DOI Listing
January 2019

Antioxidant, anti-inflammatory and cytotoxic/antitumoral bioactives from the phylum Basidiomycota and their possible mechanisms of action.

Biomed Pharmacother 2019 Feb 19;112:108643. Epub 2019 Feb 19.

Postgraduate Program in Biotechnology (RENORBIO), Federal University of Piauí, Teresina, Piauí, Brazil; Postgraduate Program in Pharmaceutical Sciences, Federal University of Piauí, Teresina, Piauí, Brazil.

Biologically active compounds from species of the phylum Basidiomycota have been shown a wide range of pharmacological activities and provide a vast reservoir of potential innovational drugs. The aim of this review is to discuss some mechanisms of action involved in antioxidant, anti-inflammatory and cytotoxic/antitumoral activities attributed to the bioactive compounds from species of the phylum Basidiomycota. We show that isolated compounds from extracts, secondary metabolites and polysaccharides that presented antioxidant properties have mechanisms of action involved in the elimination/capture of free radicals and reduction of lipid peroxidation. Read More

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http://dx.doi.org/10.1016/j.biopha.2019.108643DOI Listing
February 2019

Effects of plasma glucose levels on regional cerebral 18F-fluorodeoxyglucose uptake: Implications for dementia evaluation with brain PET imaging.

Biomed Pharmacother 2019 Feb 20;112:108628. Epub 2019 Feb 20.

Division of Nuclear Medicine, Department of Radiology, University of Michigan, Ann Arbor, MI, USA; Nuclear Medicine Service, Department of Veterans Affairs Healthcare System, Ann Arbor, MI, USA.

Purpose: Hyperglycemia affects FDG uptake in the brain, potentially emulating Alzheimer's disease in normal individuals. This study investigates global and regional cerebral FDG uptake as a function of plasma glucose in a cohort of patients.

Methods: 120 consecutive male patients with FDG PET/CT for initial oncologic staging (July-Dec 2015) were reviewed. Read More

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http://dx.doi.org/10.1016/j.biopha.2019.108628DOI Listing
February 2019

Bone marrow mesenchymal stem cells suppress growth and promote the apoptosis of glioma U251 cells through downregulation of the PI3K/AKT signaling pathway.

Biomed Pharmacother 2019 Feb 19;112:108625. Epub 2019 Feb 19.

Key Laboratory of Preclinical Study for New Drugs of Gansu Province, Lanzhou, Gansu, 730000, China; School of Basic Medical Sciences, Lanzhou University, Lanzhou, Gansu, 730000, China. Electronic address:

Mesenchymal stem cells (MSCs), with the capacity for self-renewal and differentiation into multiple cell types, exhibit the property of homing towards tumor sites and immunosuppression and have been used as tumor-tropic vectors for tumor therapy. However, few studies have investigated the underlying molecular mechanisms that link MSCs to targeted tumor cells. In this study, we elucidated the inhibitory effects and mechanisms of human bone marrow mesenchymal stem cells (hBMSCs) on human glioma U251 cells using a co-culture system in vitro. Read More

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http://dx.doi.org/10.1016/j.biopha.2019.108625DOI Listing
February 2019

Action of copper(II) complex with β-diketone and 1,10-phenanthroline (CBP-01) on sarcoma cells and biological effects under cell death.

Biomed Pharmacother 2019 Feb 18;112:108586. Epub 2019 Feb 18.

Biotechnology Institute, Federal University of Uberlândia, MG, Brazil. Electronic address:

This work reports the biological evaluation of a copper complex of the type [Cu(O-O)(N-N)ClO], in which O-O = 4,4,4-trifluoro-1-phenyl-1,3-butanedione (Hbta) and N-N = 1,10-phenanthroline (phen), whose generic name is CBP-01. The cytotoxic effect of CBP-01 was evaluated by resazurin assay and cell proliferation was determined by MTT assay. DNA fragmentation was analyzed by gel electrophoresis. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07533322183709
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http://dx.doi.org/10.1016/j.biopha.2019.01.047DOI Listing
February 2019
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Analysis of 44 pharmaceuticals consumed by elderly using liquid chromatography coupled to tandem mass spectrometry.

J Pharm Biomed Anal 2019 Feb 13;168:55-63. Epub 2019 Feb 13.

Department of Environmental Chemistry, IDAEA-CSIC, Jordi Girona 18-26, 08034, Barcelona, Catalonia, Spain.

Elderly people represent about the 15% of the total world population and often include a polymedicated age group with an average consumption of 5-10 pills per day. The main pharmaceuticals consumed are antianalgesics, antidiabetics, anti-parkinson compounds, anti-convulsants, drugs to treat constipation and drugs to treat cancer. In this study, we have developed a multiresidue method for the analysis of 44 selected pharmaceuticals prioritized according to the foremost consumption by the elderly in effluents from senior residences. Read More

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http://dx.doi.org/10.1016/j.jpba.2019.02.016DOI Listing
February 2019

A fragment-based approach towards the discovery of N-substituted tropinones as inhibitors of Mycobacterium tuberculosis transcriptional regulator EthR2.

Eur J Med Chem 2019 Feb 10;167:426-438. Epub 2019 Feb 10.

Univ. Lille, Inserm, Institut Pasteur de Lille, U1177 - Drugs and Molecules for Living Systems, F-59000, Lille, France.

Tuberculosis (TB) caused by the pathogen Mycobacterium tuberculosis, represents one of the most challenging threat to public health worldwide, and with the increasing resistance to approved TB drugs, it is needed to develop new strategies to address this issue. Ethionamide is one of the most widely used drugs for the treatment of multidrug-resistant TB. It is a prodrug that requires activation by mycobacterial monooxygenases to inhibit the enoyl-ACP reductase InhA, which is involved in mycolic acid biosynthesis. Read More

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http://dx.doi.org/10.1016/j.ejmech.2019.02.023DOI Listing
February 2019

Novel prenyloxy chalcones as potential leishmanicidal and trypanocidal agents: Design, synthesis and evaluation.

Eur J Med Chem 2019 Feb 12;167:402-413. Epub 2019 Feb 12.

Facultad de Ciencias Químicas, Universidad Autónoma de Chihuahua, Circuito Universitario, Campus Universitario, Apartado Postal 669, Chihuahua, Chih., Mexico. Electronic address:

The available drugs for treating Leishmaniasis and American trypanosomiasis have high toxicity and multiple side effects, among other problems. More effective and less toxic treatments are urgently needed. A series of chalcones that contained a prenyloxy or geranyloxy substituent was synthesized and characterized. Read More

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http://dx.doi.org/10.1016/j.ejmech.2019.02.028DOI Listing
February 2019

New NSAID-Pt(IV) prodrugs to suppress metastasis and invasion of tumor cells and enhance anti-tumor effect in vitro and in vivo.

Eur J Med Chem 2019 Feb 13;167:377-387. Epub 2019 Feb 13.

Department of Chemistry, University of Science and Technology of China, Hefei, Anhui, 230026, China. Electronic address:

The great interest in epithelial-to-mesenchymal transition (EMT) programme lies in its association with process of metastasis and invasion, which is a crucial cause of cancer-related death. Herein, we designed and reported three new NSAID-Pt(IV) prodrugs, taking Non-Steroid Anti-Inflammatory Drugs (NSAIDs) to disrupt EMT programme and assist genotoxic platinum-based drugs as a cytotoxicity booster, to offer a class of potential anticarcinogens with a multi-functional action mechanism. The NSAID-Pt(IV) prodrugs, especially Eto-Pt(IV), highly enhanced cellular uptake with amount up to 42-fold at 3 h compared with CDDP, and greatly increased DNA damage and cell apoptosis, showing much higher cytotoxicity than cisplatin in the tested cancer cells even in A549/cis cells. Read More

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http://dx.doi.org/10.1016/j.ejmech.2019.02.041DOI Listing
February 2019

Development of predicted environmental concentrations to prioritize the occurrence of pharmaceuticals in rivers from Catalonia.

Sci Total Environ 2019 Feb 13;666:57-67. Epub 2019 Feb 13.

Department of Analytical Chemistry and Organic Chemistry, Campus Sescelades, Faculty of Chemistry, Universitat Rovira i Virgili, Marcel∙lí Domingo s/n, Tarragona, Catalonia, Spain.

The main objective of the present study is to prioritize those pharmaceuticals that have higher chances to be detected in water due to incomplete removal in Wastewater Treatment Plants (WWTPs). To do so, the total consumption of pharmaceuticals in Catalonia (NE Spain) were compiled to calculate the predicted environmental concentrations (PECs) in wastewater effluents and in river water. PECs were estimated using publicly available consumption data in the period of 2013-2016 for a suite of 165 compounds. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2019.02.078DOI Listing
February 2019

Drivers of the fatal drug epidemic.

J Health Econ 2019 Jan 14;64:25-42. Epub 2019 Jan 14.

Frank Batten School of Leadership & Public Policy, University of Virginia, 235 McCormick Road, P.O. Box 400893, Charlottesville, VA, 22904-4893, United States. Electronic address:

This study examines the contributions of the medium-run evolution of local economies and of changes in the "drug environment' in explaining county-level changes in drug and related mortality rates from 1999 to 2015. A primary finding is that drug mortality rates did increase more in counties experiencing relative economic decline than in those with more robust growth, but that the relationship is weak and mostly accounted for by confounding factors. In the preferred estimates, less than one-tenth of the rise in drug and opioid-involved fatality rates is explained and the contribution is even smaller, quite possibly zero, when allowing for plausible selection on unobservables. Read More

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http://dx.doi.org/10.1016/j.jhealeco.2019.01.001DOI Listing
January 2019

Cisplatin exposure impairs ionocytes and hair cells in the skin of zebrafish embryos.

Aquat Toxicol 2019 Feb 13;209:168-177. Epub 2019 Feb 13.

Department of Life Science, School of Life Science, National Taiwan Normal University, Taipei 11677, Taiwan. Electronic address:

This study aimed to assess the sublethal effects of a platinum-based compound, cisplatin, using a zebrafish model. Zebrafish embryos were incubated in different concentrations of cisplatin at 0-96 h post-fertilization. Using a non-invasive, scanning ion-selective electrode technique (SIET), we measured the functions of hair cells (Ca influx) and ionocytes ([H] gradients). Read More

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http://dx.doi.org/10.1016/j.aquatox.2019.02.006DOI Listing
February 2019

The detection of drugs of abuse and pharmaceuticals in drinking water using solid-phase extraction and liquid chromatography-mass spectrometry.

Chemosphere 2019 Feb 14;223:438-447. Epub 2019 Feb 14.

Forensic and Investigative Sciences Research Group, Department of Biomedical and Forensic Sciences, Faculty of Science and Technology, Anglia Ruskin University, Cambridge, CB1 1PT, United Kingdom. Electronic address:

Pharmaceuticals and drugs of abuse including novel psychoactive substances (NPS) are emerging as newer contaminants in the aquatic environment. The presence of such pollutants has implications on the environment as well as public health and therefore their identification is important when monitoring water quality. This research presents a new method for the simultaneous detection of 20 drugs of abuse and pharmaceuticals in drinking water, including 15 NPS, three traditional illicit drugs and two antidepressants. Read More

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http://dx.doi.org/10.1016/j.chemosphere.2019.02.040DOI Listing
February 2019

Anticancer properties of a new non-oxido vanadium(IV) complex with a catechol-modified 3,3'-diindolylmethane ligand.

J Inorg Biochem 2019 Feb 13;194:1-6. Epub 2019 Feb 13.

Organic Chemistry Laboratory, University of Bayreuth, Universitaetsstrasse 30, 95447 Bayreuth, Germany.

In order to identify new active drug candidates against cancer diseases we investigated the tumor cell growth inhibition, formation of reactive oxygen species, mitochondrial membrane damage, cell cycle arrest and DNA binding activity of a new bis(triethylammonium) tris[1,1-bis(indol-3-yl)-1-(3,4-catecholate)methane]vanadate(IV) complex. It exhibited significant antiproliferative activity against various cancer cell lines, showed a stronger DNA binding than cisplatin and led to mitochondrial damage, a formation of reactive oxygen species, and a cell cycle arrest in the G2/M phase of cancer cells. Read More

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http://dx.doi.org/10.1016/j.jinorgbio.2019.02.005DOI Listing
February 2019

Antiarrhythmic Drugs for Atrial Fibrillation in the Real World: Trick or Treat.

JACC Clin Electrophysiol 2019 Feb;5(2):242-244

Electrophysiology Program, Penn State University Heart and Vascular Institute, The Milton S. Hershey Medical Center, Penn State University College of Medicine, Hershey, Pennsylvania. Electronic address:

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http://dx.doi.org/10.1016/j.jacep.2018.10.013DOI Listing
February 2019

Real-World Comparison of Classes IC and III Antiarrhythmic Drugs as an Initial Rhythm Control Strategy in Newly Diagnosed Atrial Fibrillation: From the TREAT-AF Study.

JACC Clin Electrophysiol 2019 Feb 1;5(2):231-241. Epub 2018 Nov 1.

Veterans Affairs Palo Alto Health Care System, Palo Alto, California; Department of Medicine, Stanford University School of Medicine, Stanford, California; Center for Digital Health, Stanford University School of Medicine, Stanford, California. Electronic address:

Objectives: In this study the authors investigated effectiveness and safety of an initial treatment strategy with class IC or class III antiarrhythmic drugs (AAD) for newly diagnosed atrial fibrillation (AF) or atrial flutter (AFL).

Background: There is limited evidence to guide optimal AAD selection for rhythm control in newly diagnosed AF/AFL.

Methods: Using data from TREAT-AF (The Retrospective Evaluation and Assessment of Therapies in AF), the authors performed a retrospective cohort study of patients with AF/AFL from 2004 to 2014 and class IC or class III AAD prescription within 90 days following diagnosis. Read More

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http://dx.doi.org/10.1016/j.jacep.2018.08.025DOI Listing
February 2019
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