1,430,553 results match your criteria Drugs: Education Prevention and Policy [Journal]


A randomized, double-blind, placebo-controlled trial to assess the efficAcy and safety of Trimetazidine in patients with angina pectoris having been treated by percutaneous coronary intervention (ATPCI study): Rationale, design, and baseline characteristics.

Am Heart J 2019 Jan 15;210:98-107. Epub 2019 Jan 15.

Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Européen Georges Pompidou (HEGP), Department of Cardiology, Paris, France; Université Paris-Descartes, Paris, France; INSERM U-970, Paris, France.

Background: About 30% of angina patients have persisting symptoms despite successful revascularization and antianginal therapy. Moreover, in stable patients, percutaneous coronary intervention (PCI) does not improve survival as compared with medical therapy alone. Trimetazidine, an antianginal agent devoid of hemodynamic effect, may help reducing symptoms and improving outcomes after PCI. Read More

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http://dx.doi.org/10.1016/j.ahj.2018.12.015DOI Listing
January 2019

Recent advances of anti-cancer therapies including the use of cell-penetrating peptides.

Curr Opin Pharmacol 2019 Feb 13;47:8-13. Epub 2019 Feb 13.

University of Cologne, Department of Chemistry, Biochemistry, Zülpicher Str. 47a, 50674 Cologne, Germany. Electronic address:

Cancer is one of the major growing public health problems making the development of new anti-cancer treatment strategies still compulsory. Conventionally used chemotherapies are quite often associated with severe side effects. One reason is limited cell-permeability of the used drugs resulting in only poor overall bioavailability. Read More

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http://dx.doi.org/10.1016/j.coph.2019.01.003DOI Listing
February 2019

Metabolic shift of Staphylococcus aureus under sublethal dose of methicillin in the presence of glucose.

J Pharm Biomed Anal 2019 Feb 8;167:140-148. Epub 2019 Feb 8.

Department of Chemistry and Biochemistry, Miami University, Oxford, OH, 45056, USA; Department of Human Sciences, The Ohio State University, Columbus, OH, 43210, USA. Electronic address:

Traditional strategies in developing novel drugs to treat antibiotic-resistant S. aureus have not been very successful to date, therefore, there is an urgent need for creative usage of existing agents that can treat and control S. aureus infection. Read More

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http://dx.doi.org/10.1016/j.jpba.2019.02.010DOI Listing
February 2019

Leveraging the Medicines for Malaria Venture malaria and pathogen boxes to discover chemical inhibitors of East Coast fever.

Int J Parasitol Drugs Drug Resist 2019 Jan 25;9:80-86. Epub 2019 Jan 25.

International Livestock Research Institute, P. O. Box 30709, Nairobi, Kenya. Electronic address:

Chemotherapy of East Coast fever, a lymphoproliferative cancer-like disease of cattle causing significant economic losses in Africa, is largely dependent on the use of buparvaquone, a drug that was developed in the late 1980's. The disease is caused by the tick-borne protozoan pathogen Theileria parva. Buparvaquone can be used prophylactically and it is also active against tropical theileriosis, caused by the related parasite Theileria annulata. Read More

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http://dx.doi.org/10.1016/j.ijpddr.2019.01.002DOI Listing
January 2019

Repurposing nitrocatechols: 5-Nitro-α-cyanocarboxamide derivatives of caffeic acid and caffeic acid phenethyl ester effectively inhibit aggregation of tau-derived hexapeptide AcPHF6.

Eur J Med Chem 2019 Feb 4;167:146-152. Epub 2019 Feb 4.

CIQUP/Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, Rua do Campo Alegre s/n, 4169-007, Porto, Portugal. Electronic address:

Polyphenols like caffeic acid and its phenethyl ester have been associated with potent anti-aggregating activity. Accordingly, we screened a library of polyphenols and synthetic derivatives thereof for their capacity to inhibit tau-aggregation using a thioflavin T-based fluorescence method. Our results show that the nitrocatechol scaffold is required for a significant anti-aggregating activity, which is enhanced by introducing bulky substituents at the side chain. Read More

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http://dx.doi.org/10.1016/j.ejmech.2019.02.006DOI Listing
February 2019

Multivariate copula temporal modeling of intersection crash consequence metrics: A joint estimation of injury severity, crash type, vehicle damage and driver error.

Accid Anal Prev 2019 Feb 13;125:188-197. Epub 2019 Feb 13.

Connecticut Transportation Safety Research Center, Connecticut Transportation Institute, University of Connecticut, United States. Electronic address:

This study employs a copula-based multivariate temporal ordered probit model to simultaneously estimate the four common intersection crash consequence metrics - driver error, crash type, vehicle damage and injury severity - by accounting for potential correlations due to common observed and unobserved factors, while also accommodating the temporal instability of model estimates over time. To this end, a comprehensive literature review of relevant studies was conducted; four different copula model specifications including Frank, Clayton, Joe and Gumbel were estimated to identify the dominant factors contributing to each crash consequence indicator; the temporal effects on model estimates were investigated; the elasticity effects of the independent variables with regard to all four crash consequence indicators were measured to express the magnitude of the effects of an independent variable on the probability change for each level of four indicators; and specific countermeasures were recommended for each of the contributing factors to improve the intersection safety. The model goodness-of-fit illustrates that the Joe copula model with the parameterized copula parameters outperforms the other models, which verifies that the injury severity, crash type, vehicle damage and driver error are significantly correlated due to common observed and unobserved factors and, accounting for their correlations, can lead to more accurate model estimation results. Read More

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http://dx.doi.org/10.1016/j.aap.2019.01.036DOI Listing
February 2019

Barriers against a successful MS treatment: The importance of effectiveness beyond efficacy.

Mult Scler Relat Disord 2019 Feb 7;30:129-135. Epub 2019 Feb 7.

Neurology Department, Hospital Italiano y Español de La Plata, La Plata, Argentina.

Current multiple sclerosis (MS) therapeutic options have significantly increased treatment algorithm complexity. This urges physicians to take into account multiple factors in the decision-making process and make an even more thorough analysis of the risk-benefit balance. We carried out a descriptive review aiming to assess some factors that endanger the proper MS treatment fulfillment, focusing mainly on Latin American countries. Read More

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http://dx.doi.org/10.1016/j.msard.2019.01.056DOI Listing
February 2019

Antiepileptic therapy approaches in KCNQ2 related epilepsy: A systematic review.

Eur J Med Genet 2019 Feb 13. Epub 2019 Feb 13.

Division of Pediatric Neurology, Developmental Medicine and Social Pediatrics, Dr. von Haunersches Children's Hospital, LMU Munich, Lindwurmstraße4, 80337, Munich, Germany; Comprehensive Epilepsy Center for Children, Adolescents and Adults, LMU Munich, Lindwurmstraße 4, 80337, Munich, Germany. Electronic address:

Background: KCNQ2 related disorders comprise both benign seizure disorders and early onset epileptic encephalopathies. Especially within the latter group, patients suffer from refractory seizures to standard antiepileptic drugs and developmental delay. Besides the hope of personalized medical approaches to treat the recently unraveled large amount of genetic channelopathies, there are sparse systematic data on treatment responses in KCNQ2 related epilepsy in larger cohorts. Read More

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http://dx.doi.org/10.1016/j.ejmg.2019.02.001DOI Listing
February 2019

Entry of therapeutics into the brain: influence of exposed polarity calculated in silico and measured in vitro by supercritical fluid chromatography.

Int J Pharm 2019 Feb 13. Epub 2019 Feb 13.

Worldwide Medicinal Chemistry, Pfizer Global Research & Development, Groton Laboratories, Eastern Point Road, Groton, Connecticut 06340, United States. Electronic address:

The present work proposes a novel application of EPSA (not an acronym but found to be referred to by many as Exposed Polar Surface Area), a supercritical fluid chromatography (SFC) polarity readout for assisting in the prediction of the extent of drug permeation through the blood-brain barrier (BBB). For this purpose, EPSA values for 69 structurally unrelated acidic, basic, neutral and amphoteric compounds were determined by a validated SFC method. Additionally, water-accessible surface area (WASA) values for the whole dataset were calculated in silico and compared to experimentally determined EPSA values. Read More

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http://dx.doi.org/10.1016/j.ijpharm.2019.02.008DOI Listing
February 2019

RLIP: An existential requirement for breast carcinogenesis.

Biochim Biophys Acta Rev Cancer 2019 Feb 13. Epub 2019 Feb 13.

Department of Internal Medicine, Division of Hematology & Oncology, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA.

Breast cancer (BC) is the most common cancer among women worldwide. Due to its complexity in nature, effective BC treatment can encounter many challenges. The human RALBP1 gene encodes a 76-kDa splice variant protein, RLIP (ral-binding protein1, RalBP1), a stress-protective mercapturic acid pathway (MAP) transporter protein, that also plays a key role in regulating clathrin-dependent endocytosis (CDE) as a Ral effector. Read More

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http://dx.doi.org/10.1016/j.bbcan.2019.02.001DOI Listing
February 2019

Towards the first targeted therapy for triple-negative breast cancer: repositioning of clofazimine as a chemotherapy-compatible selective Wnt pathway inhibitor.

Cancer Lett 2019 Feb 13. Epub 2019 Feb 13.

Department of Cell Physiology and Metabolism, Translational Research Centre in Oncohaematology, Faculty of Medicine, University of Geneva, Geneva, Switzerland; School of Biomedicine, Far Eastern Federal University, Vladivostok, Russia. Electronic address:

Wnt signaling is overactivated in triple-negative breast cancer (TNBC) and several other cancers, and its suppression emerges as an effective anticancer treatment. However, no drugs targeting the Wnt pathway exist on the market nor in advanced clinical trials. Here we provide a comprehensive body of preclinical evidence that an anti-leprotic drug clofazimine is effective against TNBC. Read More

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http://dx.doi.org/10.1016/j.canlet.2019.02.018DOI Listing
February 2019

USP39 regulates DNA damage response and chemo-radiation resistance by deubiquitinating and stabilizing CHK2.

Cancer Lett 2019 Feb 13. Epub 2019 Feb 13.

Research Center for Translational Medicine, East Hospital, Tongji University School of Medicine, Shanghai, 200120, China; Key Laboratory of Arrhythmias of the Ministry of Education of China, East Hospital, Tongji University School of Medicine, Shanghai, 200120, China. Electronic address:

The serine/threonine kinase, CHK2 (checkpoint kinase 2), is a key mediator in DNA damage response and a tumor suppressor, which is implicated in promoting cell cycle arrest, apoptosis and DNA repair. Accumulating evidence suggests that these functions are primarily exerted through phosphorylation downstream factors such as p53 and BRCA1. Recent studies have shown that ubiquitination is an important mode of regulation of CHK2. Read More

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http://dx.doi.org/10.1016/j.canlet.2019.02.015DOI Listing
February 2019

Drugs used for neurological and psychiatric conditions increase the risk of bullous pemphigoid: a case-control study.

J Am Acad Dermatol 2019 Feb 13. Epub 2019 Feb 13.

PEDEGO Research Unit, University of Oulu; Department of Dermatology and Medical Research Center Oulu, Oulu University Hospital, Oulu, Finland.

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http://dx.doi.org/10.1016/j.jaad.2019.02.017DOI Listing
February 2019

Sequential activation of anticancer therapy triggered by tumor microenvironment-selective imaging.

J Control Release 2019 Feb 13. Epub 2019 Feb 13.

College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul 08826, Republic of Korea. Electronic address:

The combination of imaging and anticancer therapy has recently emerged as a promising strategy. However, nonspecific imaging signals and distribution of anticancer drugs at normal tissues limit the specificity of the combination therapy. To overcome the challenges, we designed a system which can selectively visualize cancer tissues and initiate the subsequent action of therapeutic molecules in tumor microenvironment. Read More

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http://dx.doi.org/10.1016/j.jconrel.2019.02.012DOI Listing
February 2019

Cumulative multiple early life hits- a potent threat leading to neurological disorders.

Brain Res Bull 2019 Feb 13. Epub 2019 Feb 13.

School of Studies in Neuroscience, Jiwaji University, Gwalior, India; School of Studies in Zoology, Jiwaji University, Gwalior, India. Electronic address:

Early life Stress is a worldwide concern linked with development of later life neurological disorder. Early developmental age is sensitive to many prominent environmental insults like malnourishment, immune inflammation, abuse, maternal separation, alcohol and drugs. Hence, an individual during an early age encounters more than one simultaneous stressor that leads to impairment of cognitive and behavioral abilities, a symptom common to most of the neurological disorders. Read More

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http://dx.doi.org/10.1016/j.brainresbull.2019.02.005DOI Listing
February 2019

Evaluation of structural, functional, and anti-oxidant potential of differentially extracted polysaccharides from potatoes peels.

Int J Biol Macromol 2019 Feb 13. Epub 2019 Feb 13.

School of Food and Biological Engineering, Hefei University of Technology, Hefei 230009, People's Republic of China; Anhui Province Key Laboratory of Functional Compound Seasoning, Anhui Qiangwang seasoning Food Co., Ltd., Jieshou 236500, People's Republic of China. Electronic address:

Potato peel was used for the extraction of three types of polysaccharides (PW, PAL, and PAC) using water, alkaline, and acid treatments, respectively. The structure of the PP polysaccharides was examined by means of Fourier transform infrared spectroscopy (FT-IR) analysis and Gas chromatography-mass spectrometry (GC-MS). The results suggest that the extracted polysaccharides constituted essentially three functional groups; CO, CH, and OH. Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2019.02.074DOI Listing
February 2019

The molecular structure of an epoxide hydrolase from Trichoderma reesei in complex with urea or amide-based inhibitors.

Int J Biol Macromol 2019 Feb 13. Epub 2019 Feb 13.

Escola de Artes, Ciências e Humanidades, Universidade de São Paulo, 1000 Arlindo Bettio Avenue, 03828-000 São Paulo, Brazil. Electronic address:

Epoxide hydrolases (EHs) are enzymes involved in the metabolism of endogenous and exogenous epoxides, and the development of EH inhibitors has important applications in the medicine. In humans, EH inhibitors are being tested in the treatment of cardiovascular diseases and show potent anti-inflammatory effects. EH inhibitors are also considerate promising molecules against infectious diseases. Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2019.02.070DOI Listing
February 2019

Chitosan nanopolymers: An overview of drug delivery against cancer.

Int J Biol Macromol 2019 Feb 13. Epub 2019 Feb 13.

Innovative Green Product Synthesis and Renewable Environment Development Research Group, Faculty of Environment and Labour Safety, Ton Duc Thang University, Ho Chi Minh City, Viet Nam. Electronic address:

Cancer is becoming a major reason for death troll worldwide due to the difficulty in finding an efficient, cost effective and target specific method of treatment or diagnosis. The variety of cancer therapy used in the present scenario have painful side effect, low effectiveness and high cost, which is a major drawback of the available therapies. Apart from the conventional cancer therapy, nanotechnology has grown extremely towards treating cancer. Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2019.02.060DOI Listing
February 2019

H NMR characterization of chitin tetrasaccharide in binary HO:DMSO solution: Evidence for anomeric end-effect propagation.

Int J Biol Macromol 2019 Feb 13. Epub 2019 Feb 13.

Department of Chemistry, University of California - Riverside, Riverside, CA 92521, United States. Electronic address:

Chitin oligosaccharides, composed of homogeneous β(1 → 4)-linked N-acetyl-D-glucosamine (GlcNAc) sequences, is a well-known elicitor of plant immune defense, and also occur as structural elements of chitosan and nodulation (Nod) factor. Detailed microstructure characterization is required for understanding the function mode of these bioactive molecules. Herein, experimental conditions for detection and elucidation of the H NMR resonances of amide groups in chitin oligosaccharides are presented. Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2019.02.062DOI Listing
February 2019

Prenatal cannabinoid exposure and altered neurotransmission.

Neuropharmacology 2019 Feb 13. Epub 2019 Feb 13.

Department of Drug Discovery and Development, Auburn University, Auburn, Alabama, USA; Center for Neuroscience Initiative, Auburn University, Auburn, Alabama, USA. Electronic address:

Marijuana is one of the most commonly used illicit drugs worldwide. In addition, use of synthetic cannabinoids is increasing, especially among adolescents and young adults. Although human studies have shown that the use of marijuana during pregnancy leads to adverse behavioral effects, such as deficiencies in attention and executive function in affected offspring, the rate of marijuana use among pregnant women is steadily increasing. Read More

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http://dx.doi.org/10.1016/j.neuropharm.2019.02.018DOI Listing
February 2019

Toxicological assessment compilation of selected examples of raw materials for homeopathic medicinal products.

Regul Toxicol Pharmacol 2019 Feb 13. Epub 2019 Feb 13.

Federal Institute for Drugs and Medical Devices (Bundesinstitut für Arzneimittel und Medizinprodukte, BfArM), Kurt-Georg-Kiesinger-Allee 3, 53175, Bonn, Germany.

The considerable number of homeopathic medicinal products (HMP) on the German market and the staggering breadth of active substances of various origin along with the specific legal requirements of adequate safety principles posed the need to compile data on toxicologically evaluated raw materials. In line with the European regulatory framework, HMP applications must consider appropriate safety standards in analogy to conventional human medicinal products. This review presents an option for a systematic and scientifically substantiated approach for regulatory use. Read More

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http://dx.doi.org/10.1016/j.yrtph.2019.02.007DOI Listing
February 2019

Isolation and characterization of a naturally occurring multidrug-resistant strain of the canine hookworm, Ancylostoma caninum.

Int J Parasitol 2019 Feb 13. Epub 2019 Feb 13.

Department of Microbiology, Immunology, and Tropical Medicine, Ross Hall, 2300 I St. NW, The George Washington University, Washington, DC, 20052, USA. Electronic address:

Soil-transmitted nematodes (STNs) infect over a billion people and place several billion more at risk of infection. Hookworm disease is the most significant of these STNs, with over 500 million people infected. Hookworm infection can result in debilitating and sometimes fatal iron-deficiency anemia, which is particularly devastating in children and pregnant women. Read More

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http://dx.doi.org/10.1016/j.ijpara.2018.12.004DOI Listing
February 2019

G Protein-Coupled Receptors are Dynamic Regulators of Digestion and Targets for Digestive Diseases.

Gastroenterology 2019 Feb 13. Epub 2019 Feb 13.

Monash Institute of Pharmaceutical Sciences, and Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash University, Parkville, VIC 3052, Australia; Department of Pharmacology and Therapeutics, University of Melbourne, Parkville, VIC 3010, Australia; Columbia University College of Physicians and Surgeons, Columbia University in the City of New York, 21 Audubon Avenue, Rm 209, New York City, NY 10032, USA. Electronic address:

G protein-coupled receptors (GPCRs) are the largest family of transmembrane signaling proteins. Within the gastrointestinal tract, GPCRs expressed by epithelial cells sense contents of the lumen, and GPCRs expressed by epithelial cells, myocytes, neurons, and immune cells participate in communication amongst cells. GPCRs control digestion, mediate digestive diseases, and coordinate repair and growth. Read More

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http://dx.doi.org/10.1053/j.gastro.2019.01.266DOI Listing
February 2019

Neuroprotective effects of agmatine in antineoplastic drugs induced neurotoxicity: In vitro study.

Life Sci 2019 Feb 13. Epub 2019 Feb 13.

Department of Pharmacology and Psychopharmacology Research Unit, Marmara University School of Pharmacy, Istanbul, Turkey.

Aims: The effects of agmatine, an endogenous substance known to have a neuroprotective effect against neurotoxicity has been investigated.

Material And Methods: The primary neuron culture obtained from neonatal rats was exposed to toxicity with paclitaxel and cisplatin and the effect of agmatine on both acute (1 h) and chronic (24 h) exposure was demonstrated by biochemical and molecular analyses. It was demonstrated that the effect of agmatine before and after agmatine was induced by neurotoxicity before agmatine and the effect of agmatine on the formed and occuring toxicities. Read More

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http://dx.doi.org/10.1016/j.lfs.2019.02.018DOI Listing
February 2019

Macro and microfilaricidal activities of extracts of Annona senegalensis and Milletia comosa against Onchocerca ochengi and Loa loa.

Exp Parasitol 2019 Feb 13. Epub 2019 Feb 13.

Laboratory for Drugs and Molecular Diagnostics Research (ANDI Centre of Excellence for Onchocerciasis Drug Research), Biotechnology Unit, University of Buea, Cameroon; Department of Biochemistry and Molecular Biology, Faculty of Science, University of Buea, P.O. Box 63, Buea, Cameroon. Electronic address:

Despite the efforts employed for the control of onchocerciasis, the latter has remained a significant public health problem, due mainly to the lack of safe and effective adult worm drugs and/or microfilaricides that do not kill Loa loa microfilariae (mf). Serious adverse events have been encountered after administering ivermectin to some onchocerciasis patients coinfected with Loa loa. There is therefore, an urgent need for a macro and/or microfilaricidal drug which kills Onchocerca but not L. Read More

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http://dx.doi.org/10.1016/j.exppara.2019.02.004DOI Listing
February 2019

New treatment option for delta virus: is a cure in sight?

Authors:
Cihan Yurdaydin

J Viral Hepat 2019 Feb 16. Epub 2019 Feb 16.

Department of Gastroenterology, Ankara University Medical School, Cebeci Tıp Fakültesi Hastanesi, Dikimevi, 06100, Ankara, Turkey.

Current treatment of chronic hepatitis D viral infection with interferons is poorly tolerated and effective only in a minority of patients. Despite Delta virus causing the most severe form of chronic viral hepatitis no other treatments are available. After many years of inactivity there is now hope for new treatment approaches for Delta virus and some are likely to enter clinical practice in the near future. Read More

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http://dx.doi.org/10.1111/jvh.13081DOI Listing
February 2019

Localization of malonyl and acetyl on substituted saikosaponins according to the full-scan mass spectra and the fragmentation of sodium-adduct ions in the positive mode.

Rapid Commun Mass Spectrom 2019 Feb 16. Epub 2019 Feb 16.

Medical College, Jiaxing University, 118 Jiahang Road, Jiaxing, Zhejiang Province, China.

Rationale: It's a long-lasting unsettled issue to discriminate between aglycone-substituted and saccharide-substituted saikosaponins by LC-MS . It's necessary to characterize the two types of substituted saikosaponins taking into consideration their potential significant difference in bioactivity.

Methods: Taking the substituents of malonyl and acetyl as example, we developed a MS strategy to discriminate between the aglycone-substituted and saccharide-substituted saikosaponins through comparing their Y -nH O (n=1-2) ions from the protonated molecules in the full-scan mass spectra and their B ions in the MS spectra of sodium-adduct molecules in the positive mode. Read More

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http://dx.doi.org/10.1002/rcm.8415DOI Listing
February 2019

Use of Affinity Allows Anti-Inflammatory and Anti-Microbial Dual Release that Matches Suture Wound Resolution.

J Biomed Mater Res A 2019 Feb 16. Epub 2019 Feb 16.

Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH 44106.

Surgical sutures are vulnerable to bacterial infections and biofilm formation. At the suture site, pain and undesirable, excess inflammation are additionally detrimental to wound healing. The development of a polymerized cyclodextrin (pCD) coated surgical suture introduces the capability to locally deliver both anti-inflammatory and anti-microbial drugs throughout the phases of acute and chronic healing. Read More

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http://dx.doi.org/10.1002/jbm.a.36658DOI Listing
February 2019

Prevalence and Correlates of Injecting with Visitors from the United States Among People Who Inject Drugs in Tijuana, Mexico.

J Immigr Minor Health 2019 Feb 15. Epub 2019 Feb 15.

Department of Medicine, School of Medicine, University of California San Diego, 9500 Gilman Drive, MC-0725, La Jolla, CA, 92093-0725, USA.

Cross-border infectious disease transmission is a concern related to drug tourism from the U.S. to Mexico. Read More

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http://dx.doi.org/10.1007/s10903-019-00868-8DOI Listing
February 2019

Acute multiple sclerosis lesion pathology does not predict subsequent clinical course-a biopsy study.

Ir J Med Sci 2019 Feb 15. Epub 2019 Feb 15.

Department of Neuropathology, Beaumont Hospital, Beaumont Road, Dublin, Ireland.

Background: Knowledge of the clinical outcome in tumefactive demyelination remains limited.

Aims: This study aims to characterise the natural history of biopsy-proven, pathogen-free, cerebral demyelination in an adult Irish population.

Methods: We identified all patients with biopsy-proven demyelination in a single neuropathology centre between 1999 and 2017. Read More

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http://dx.doi.org/10.1007/s11845-019-01983-zDOI Listing
February 2019

Risk factors and control of seizures in 778 Chinese patients undergoing initial resection of supratentorial meningiomas.

Neurosurg Rev 2019 Feb 15. Epub 2019 Feb 15.

Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, No.119 South 4th Ring West Road, Fengtai District, Beijing, 100070, China.

This retrospective study explored the risk factors for the occurrence of seizures in the pre- and postoperative period in patients undergoing supratentorial meningiomas surgery to investigate those who are likely to benefit from prophylactic antiepileptic drugs (AEDs). We reviewed the medical records of 778 supratentorial meningiomas patients who were operated at our institution between 2011 and 2012. A total of 100 (12. Read More

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http://dx.doi.org/10.1007/s10143-019-01085-5DOI Listing
February 2019

Relationship Between Substance Use, Bullying, and Other Delinquent Behaviors Among High School Students: a Secondary Analysis of the Florida Youth Substance Abuse Survey.

J Behav Health Serv Res 2019 Feb 15. Epub 2019 Feb 15.

Department of Mental Health Law & Policy, MHC 2712, University of South Florida, 13301 Bruce B. Downs Blvd., Tampa, FL, 33612, USA.

Substance use and bullying during adolescence are two prevalent problem behaviors associated with a broad array of adverse developmental outcomes. This study conducted a secondary analysis of high school data from Hillsborough County's 2014 Florida Youth Substance Abuse Survey to examine the relationship between substance use, criminal activity, bullying, and other deviant behaviors. Results indicated that past-month alcohol and marijuana use were associated with driving under the influence of marijuana or alcohol, riding with a driver under the influence of marijuana or alcohol, carrying a hand gun, gambling, selling illegal drugs, and the perpetration of bullying. Read More

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http://dx.doi.org/10.1007/s11414-019-09649-5DOI Listing
February 2019

Delivery Systems as Vital Tools in Drug Repurposing.

AAPS PharmSciTech 2019 Feb 15;20(3):116. Epub 2019 Feb 15.

Advanced Drug Delivery Laboratory, Department of Pharmaceutical Sciences, College of Pharmacy, Northeast Ohio Medical University, 4209 State Route 44, Rootstown, Ohio, 44272, USA.

The process of developing an old drug for new indications is now a widely accepted strategy of shortening drug development time, reducing drug costs, and improving drug availability, especially for rare and neglected diseases. In this mini-review, we highlighted the impact of drug delivery systems in the fulfillment of crucial aspects of drug repurposing such as (i) maximizing the repurposed drug effects on a new target, (ii) minimizing off-target effects, (iii) modulating the release profiles of drug at the site of absorption, (iv) modulating the pharmacokinetics/in vivo biodistribution of the repurposed drug, (v) targeting/modulating drug retention at the sites of action, and (vi) providing a suitable platform for therapeutic application of combination drugs. Read More

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http://dx.doi.org/10.1208/s12249-019-1333-zDOI Listing
February 2019

N/OFQ-NOP System in Peripheral and Central Immunomodulation.

Handb Exp Pharmacol 2019 Feb 16. Epub 2019 Feb 16.

Department of Cardiovascular Sciences, Anaesthesia Critical Care and Pain Management, University of Leicester, Leicester Royal Infirmary, Leicester, UK.

Classical opioids (μ: mu, MOP; δ: delta, DOP and κ: kappa, KOP) variably affect immune function; they are immune depressants and there is good clinical evidence in the periphery. In addition, there is evidence for a central role in the control of a number of neuropathologies, e.g. Read More

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http://link.springer.com/10.1007/164_2018_203
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http://dx.doi.org/10.1007/164_2018_203DOI Listing
February 2019
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Relationship between periodontal inflammation and calcium channel blockers induced gingival overgrowth-a cross-sectional study in a Japanese population.

Clin Oral Investig 2019 Feb 15. Epub 2019 Feb 15.

Department of Periodontal Medicine, Graduate School of Biomedical & Health Sciences, Hiroshima University, 1-2-3, Kasumi, Minami-ku, Hiroshima, 734-8553, Japan.

Objectives: Periodontal inflammation is regarded as a risk factor for drug-induced gingival overgrowth (DIGO). In order to elucidate the involvement of periodontal inflammation in DIGO, the periodontal status of subjects who do not develop DIGO despite receiving causative drugs (non-responders) needs to be examined. Therefore, the aim of the present study which was a pilot study was to assess periodontal inflammatory variables in responders (calcium channel blocker induced-GO patients), non-responders, and patients who did not receive causative drugs (non-consumers). Read More

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http://dx.doi.org/10.1007/s00784-019-02846-8DOI Listing
February 2019

Risk factors for vancomycin nephrotoxicity and time course of renal function during vancomycin treatment.

Eur J Clin Pharmacol 2019 Feb 15. Epub 2019 Feb 15.

Department of Pharmacy, Tokyo Women's Medical University Medical Center East, 2-1-10, Nishiogu, Arakawa-ku, Tokyo, 116-0011, Japan.

Purpose: Vancomycin (VCM) is used for the treatment of methicillin-resistant Staphylococcus aureus. Although the risk factors for VCM nephrotoxicity have been evaluated, the time course of renal function during VCM treatment is unknown. We assessed risk factors for VCM nephrotoxicity and how renal function varied over time. Read More

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http://dx.doi.org/10.1007/s00228-019-02648-7DOI Listing
February 2019

Aberrant Wnt signaling in multiple myeloma: molecular mechanisms and targeting options.

Leukemia 2019 Feb 15. Epub 2019 Feb 15.

Department of Pathology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

Aberrant activation of Wnt/β-catenin signaling plays a central role in the pathogenesis of a wide variety of malignancies and is typically caused by mutations in core Wnt pathway components driving constitutive, ligand-independent signaling. In multiple myelomas (MMs), however, these pathway intrinsic mutations are rare despite the fact that most tumors display aberrant Wnt pathway activity. Recent studies indicate that this activation is caused by genetic and epigenetic lesions of Wnt regulatory components, sensitizing MM cells to autocrine Wnt ligands and paracrine Wnts emanating from the bone marrow niche. Read More

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http://dx.doi.org/10.1038/s41375-019-0404-1DOI Listing
February 2019

Phenazine production promotes antibiotic tolerance and metabolic heterogeneity in Pseudomonas aeruginosa biofilms.

Nat Commun 2019 Feb 15;10(1):762. Epub 2019 Feb 15.

Department of Biological Sciences, Columbia University, New York, NY, 10027, USA.

Antibiotic efficacy can be antagonized by bioactive metabolites and other drugs present at infection sites. Pseudomonas aeruginosa, a common cause of biofilm-based infections, releases metabolites called phenazines that accept electrons to support cellular redox balancing. Here, we find that phenazines promote tolerance to clinically relevant antibiotics, such as ciprofloxacin, in P. Read More

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http://dx.doi.org/10.1038/s41467-019-08733-wDOI Listing
February 2019

MiR-451a suppressing BAP31 can inhibit proliferation and increase apoptosis through inducing ER stress in colorectal cancer.

Cell Death Dis 2019 Feb 15;10(3):152. Epub 2019 Feb 15.

Department of Pharmacology, West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, Chengdu, Sichuan, 610041, China.

The global morbidity and mortality of colorectal cancer (CRC) are ranked the third among gastrointestinal tumors in the world. MiR-451a is associated with several types of cancer, including CRC. However, the roles and mechanisms of miR-451a in CRC have not been elucidated. Read More

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http://dx.doi.org/10.1038/s41419-019-1403-xDOI Listing
February 2019

Expectation effects on brain dopamine responses to methylphenidate in cocaine use disorder.

Transl Psychiatry 2019 Feb 15;9(1):93. Epub 2019 Feb 15.

Laboratory of Neuroimaging, National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD, 20892-1013, USA.

The response to drugs of abuse is affected by expectation, which is modulated in part by dopamine (DA), which encodes for a reward prediction error. Here we assessed the effect of expectation on methylphenidate (MP)-induced striatal DA changes in 23 participants with an active cocaine use disorder (CUD) and 23 healthy controls (HC) using [C]raclopride and PET both after placebo (PL) and after MP (0.5 mg/kg, i. Read More

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http://www.nature.com/articles/s41398-019-0421-x
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http://dx.doi.org/10.1038/s41398-019-0421-xDOI Listing
February 2019
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Exosomes from glioma cells induce a tumor-like phenotype in mesenchymal stem cells by activating glycolysis.

Stem Cell Res Ther 2019 Feb 15;10(1):60. Epub 2019 Feb 15.

School of Basic Medical Sciences, Lanzhou University, Lanzhou, 730000, Gansu, China.

Background: Exosomes are nanoscale membrane vesicles secreted by both normal and cancer cells, and cancer cell-derived exosomes play an important role in the cross-talk between cancer cells and other cellular components in the tumor microenvironment. Mesenchymal stem cells (MSCs) have tropism for tumors and have been used as tumor-tropic vectors for tumor therapy; however, the safety of such therapeutic use of MSCs is unknown. In this study, we investigated the role of glioma cell-derived exosomes in the tumor-like phenotype transformation of human bone marrow mesenchymal stem cells (hBMSCs) and explored the underlying molecular mechanisms. Read More

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http://dx.doi.org/10.1186/s13287-019-1149-5DOI Listing
February 2019

First case report of thyroid abscess caused by Helicobacter cinaedi presenting with thyroid storm.

BMC Infect Dis 2019 Feb 15;19(1):166. Epub 2019 Feb 15.

Division of Pulmonary Medicine, Department of Internal Medicine, Federation of National Public Service Personnel Mutual Aid Associations, Tachikawa Hospital, 4-2-22 Nishikicho, Tachikawa, Tokyo, 190-8531, Japan.

Background: Helicobacter cinaedi is a microaerobic Gram-negative spiral-shaped bacterium that causes enteritis, cellulitis, and bacteremia in both immunocompromised and immunocompetent patients. While there have been increasing numbers of reported H. cinaedi infections recently, there has been no thyroid abscess case caused by H. Read More

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http://dx.doi.org/10.1186/s12879-019-3808-7DOI Listing
February 2019

Real world preventative drug management of migraine among Spanish neurologists.

J Headache Pain 2019 Feb 15;20(1):19. Epub 2019 Feb 15.

Headache Unit, Neurology Department, Hospital Universitario Clínico de Valladolid, Avda. Ramón y Cajal 3, 47005, Valladolid, Spain.

Background: Many different preventatives have showed efficacy in the treatment of migraine. National guidelines differ in their recommendations and patients' characteristics are usually taken into account in their selection. In Spain, real life use of preventive therapies seems to be heterogeneous. Read More

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http://dx.doi.org/10.1186/s10194-019-0971-6DOI Listing
February 2019

Potential pathological role of pro-inflammatory cytokines (IL-6, TNF-α, and IL-17) in xenotransplantation.

Xenotransplantation 2019 Feb 16:e12502. Epub 2019 Feb 16.

Department of Nephrology, Shenzhen Longhua District Central Hospital, Guangdong Medical University Affiliated Longhua District Central Hospital, Shenzhen, China.

The major limitation of organ transplantation is the shortage of available organs from deceased human donors which leads to the deaths of thousands of patients each year. Xenotransplantation is considered to be an effective way to resolve the problem. Immune rejection and coagulation dysfunction are two major hurdles for the successful survival of pig xenografts in primate recipients. Read More

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http://dx.doi.org/10.1111/xen.12502DOI Listing
February 2019

Design and synthesis of novel celastrol derivative and its antitumor activity in hepatoma cells and antiangiogenic activity in zebrafish.

J Cell Physiol 2019 Feb 15. Epub 2019 Feb 15.

Center for New Drug Research and Development, College of Life Science, Nanjing Normal University, Nanjing, People's Republic of China.

Two series of celastrol derivatives were designed and synthesized by modifying carboxylic acid at the 28th position with amino acid, and their intermediates with isobutyrate at the third position. All compounds were evaluated for their antiproliferation activity by four human cancer cell lines (SCG7901, HGC27, HepG2, and Bel7402) and one normal cell LO2. The most promising compound, compound 8, showed superior bioactivity and lower toxicity than others including celastrol. Read More

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http://dx.doi.org/10.1002/jcp.28312DOI Listing
February 2019

8-chloro-adenosine activity in FLT3-ITD acute myeloid leukemia.

J Cell Physiol 2019 Feb 15. Epub 2019 Feb 15.

Hematology Malignancies and Stem Cell Transplantation Institute, Gehr Family Center for Leukemia Research, City of Hope National Medical Center, Duarte, California.

Nucleoside analogs represent the backbone of several distinct chemotherapy regimens for acute myeloid leukemia (AML) and combination with tyrosine kinase inhibitors has improved survival of AML patients, including those harboring the poor-risk FLT3-ITD mutation. Although these compounds are effective in killing proliferating blasts, they lack activity against quiescent leukemia stem cells (LSCs), which contributes to initial treatment refractoriness or subsequent disease relapse. The reagent 8-chloro-adenosine (8-Cl-Ado) is a ribose-containing, RNA-directed nucleoside analog that is incorporated into newly transcribed RNA rather than in DNA, causing inhibition of RNA transcription. Read More

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http://dx.doi.org/10.1002/jcp.28294DOI Listing
February 2019

Sexual quality of life in patients with axial spondyloarthritis in the biologic treatment era.

J Rheumatol 2019 Feb 15. Epub 2019 Feb 15.

Faculty of Health and Sport, University of Agder, Norway. Department of Rheumatology, Sorlandet Hospital HF, Kristiansand, Department of Rheumatology, Martina Hansens Hospital, Bærum, Department of Neuroscience, Division of Rheumatology, Norwegian University of Science and Technology, Trondheim, Norway. Address correspondence to Kari Hansen Berg, PhD student and Head of Institute of Nursing Sciences, Faculty of Health and Sport, University of Agder, Norway, Postbox 422, 4604 Kristiansand Phone: 0047 93037669 E-mail:

Objective: To explore the relationship between demographic, disease related variables, treatment and sexual quality of life (SQOL) in men and women with Axial Spondyloarthritis (ax-SpA).

Methods: Ax-SpA patients were consecutively recruited from two rheumatology outpatient clinics in Sothern Norway. A broad specter of demographic, disease, treatment and quality of life data were systematically collected. Read More

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http://dx.doi.org/10.3899/jrheum.180413DOI Listing
February 2019

A Validation study of the Limulus Amebocyte Lysate test as an end-product endotoxin test for Polyvalent Horse Snake Antivenom.

PDA J Pharm Sci Technol 2019 Feb 15. Epub 2019 Feb 15.

Department of Microbiology and Immunology, Faculty of Pharmacy, Cairo University, Cairo, Egypt.

Snake antivenoms are the only definitive management of snake envenoming's. Endotoxin contamination is a serious threat to the safety of parenteral drugs. A greater understanding of the nature of LAL-Test interferences and the use permissible dilutions has minimized enhancement problems. Read More

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http://dx.doi.org/10.5731/pdajpst.2018.009522DOI Listing
February 2019

Comparative Leachable Study for Glass Vials to Demonstrate the Impact of Low Fill Volume.

PDA J Pharm Sci Technol 2019 Feb 15. Epub 2019 Feb 15.

SCHOTT AG, SCHOTT Pharma Services.

The pharmacopeia method for the measurement of the chemical durability for parenteral packaging is the hydrolytic resistance test for which the vial is filled to 90% of it's brimfull volume as described e.g.in USP <660> (1). Read More

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http://dx.doi.org/10.5731/pdajpst.2018.009472DOI Listing
February 2019

PDK1 mediates NOTCH1-mutated head and neck squamous carcinoma vulnerability to therapeutic PI3K/mTOR inhibition.

Clin Cancer Res 2019 Feb 15. Epub 2019 Feb 15.

Department of Thoracic/Head and Neck Medical Oncology, University of Texas MD Anderson Cancer Center

Purpose: Head and neck squamous cell carcinoma (HNSCC) is driven largely by the loss of tumor suppressor genes, including NOTCH1, but lacks a biomarker-driven targeted therapy. Although the PI3K/mTOR pathway is frequently altered in HNSCC, the disease has modest clinical response rates to PI3K/mTOR inhibitors and lacks validated biomarkers of response. We tested the hypothesis that an unbiased pharmacogenomics approach to PI3K/mTOR pathway inhibitors would identify novel, clinically relevant molecular vulnerabilities in HNSCC with loss of tumor suppressor function. Read More

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http://dx.doi.org/10.1158/1078-0432.CCR-18-3276DOI Listing
February 2019
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