J Biomech Eng 2021 May 19. Epub 2021 May 19.
Department of Mechanical & Aerospace Engineering, North Carolina State University, Raleigh, North Carolina, NC27695, United States; Joint UNC-NCSU Department of Biomedical Engineering, Raleigh, NC 27695.
The increasing prevalence of pulmonary ailments including asthma, chronic obstructive pulmonary disorder (COPD), lung tuberculosis and lung cancer, coupled with the success of pulmonary therapy has led to a plethora of scientific research focusing on improving the efficacy of pulmonary drug delivery systems. Recent advances in nanoscience and nanoengineering help achieve this by developing stable, potent, inhalable nano-size drug formulations that potentially increase dosages at target sites with significant therapeutic effects. In this study, we numerically analyze a novel methodology of incorporating helical air-nanoparticle streams for pulmonary nano-therapeutics, using a customized version of the open-source computational fluid dynamics (CFD) toolbox OpenFOAM. Read More