880 results match your criteria Drug-Induced Pulmonary Toxicity


A case report and literature review: previously excluded tuberculosis masked by amiodarone induced lung injury.

BMC Pharmacol Toxicol 2018 Dec 29;19(1):88. Epub 2018 Dec 29.

Institute of Physiology and Pharmacology, Lithuanian University of Health Sciences, A. Mickeviciaus str. 9, 44307, Kaunas, LT, Lithuania.

Background: Amiodarone is an antiarrhythmic drug which is used to treat and prevent several dysrhythmias. This includes ventricular tachycardia and fibrillation, wide complex tachycardia, as well as atrial fibrillation (AF) and paroxysmal supraventricular tachycardia. Amiodarone may prove to be the agent of choice where the patient is hemodynamically unstable and unsuitable for direct current (DC) cardioversion. Read More

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https://bmcpharmacoltoxicol.biomedcentral.com/articles/10.11
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http://dx.doi.org/10.1186/s40360-018-0279-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311077PMC
December 2018
3 Reads

Possible involvement of interleukin-18 in the pathology of hepatobiliary adverse effects related to treatment with ceritinib.

BMC Cancer 2018 Oct 19;18(1):995. Epub 2018 Oct 19.

Department of Respiratory Medicine, Tohoku University Graduate School of Medicine, 1-1 Seiryou-machi, Aoba-ku, Sendai, 980-8574, Japan.

Background: Ceritinib demonstrated a statistically significant effect on the progression-free survival versus chemotherapy in patients with advanced anaplastic lymphoma kinase (ALK) rearrangement in non-small cell lung cancer (NSCLC) as the first therapy or after previous treatment with crizotinib and one or two prior chemotherapy regimens in global phase 3 studies. However, some serious adverse effects related to ceritinib therapy were reported across these clinical studies. Among them, a grade 3 and 4 increase in hepatobiliary enzymes was one of the common adverse events related to treatment with ceritinib. Read More

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http://dx.doi.org/10.1186/s12885-018-4913-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6194610PMC
October 2018
1 Read

Drug-Induced Interstitial Lung Disease: A Systematic Review.

J Clin Med 2018 Oct 15;7(10). Epub 2018 Oct 15.

North West Lung Centre, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester M6 8HD, UK.

Background: Drug-induced interstitial lung disease (DIILD) occurs as a result of numerous agents, but the risk often only becomes apparent after the marketing authorisation of such agents.

Methods: In this PRISMA-compliant systematic review, we aimed to evaluate and synthesise the current literature on DIILD.

Results: Following a quality assessment, 156 full-text papers describing more than 6000 DIILD cases were included in the review. Read More

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http://www.mdpi.com/2077-0383/7/10/356
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http://dx.doi.org/10.3390/jcm7100356DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6209877PMC
October 2018
16 Reads

The hepatotoxic potential of protein kinase inhibitors predicted with Random Forest and Artificial Neural Networks.

Toxicol Lett 2018 Dec 10;299:145-148. Epub 2018 Oct 10.

Department of Clinical Pharmacology, University Hospital Basel, CH 4031 Basel, Switzerland. Electronic address:

Protein kinases (PKs) play a role in many pivotal aspects of cellular function. Dysregulation and mutations of protein kinases are involved in the development of different diseases, which might be treated by inhibition of the corresponding kinase. Protein kinase inhibitors (PKIs) are generally well tolerated, but unexpected and serious adverse events on the heart, lung, kidney and liver were observed clinically. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03784274183199
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http://dx.doi.org/10.1016/j.toxlet.2018.10.009DOI Listing
December 2018
5 Reads

"Real-Time" High-Throughput Drug and Synergy Testing for Multidrug-Resistant Bacterial Infection: A Case Report.

Front Med (Lausanne) 2018 20;5:267. Epub 2018 Sep 20.

Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States.

Antibiotic management of infections with multidrug-resistant organisms (MDRO) represents a complex clinical challenge. We report here the first patient with a severe MDRO infection managed with assistance of a novel "real-time" 3-day high-throughput screen (HTS) that allowed screening of 9 drugs in 14 combinations in 2,304 total samplings. Identified synergies were used to modify patient therapy with the goal of reducing drug-induced toxicity. Read More

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https://www.frontiersin.org/article/10.3389/fmed.2018.00267/
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http://dx.doi.org/10.3389/fmed.2018.00267DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6160733PMC
September 2018
2 Reads

Hepatic toxicity following actinomycin D chemotherapy in treatment of familial gestational trophoblastic neoplasia: A case report.

Medicine (Baltimore) 2018 Sep;97(38):e12424

Department of Obstetrics and Gynecology, West China Second Hospital of Sichuan University.

Rationale: Familial hydatidiform mole is extremely rare while familial gestational trophoblastic neoplasia (GTN) has never been reported. Inspired by 2 biological sisters with postmolar GTN and liver toxicity, we reviewed susceptible maternal-effect genes and explored the role of possible drug transporter genes in the development of GTN.

Patient Concerns: We reported one Chinese family where the two sisters developed postmolar GTN while experiencing fast remission and significant hepatic toxicity from actinomycin D chemotherapy. Read More

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http://dx.doi.org/10.1097/MD.0000000000012424DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6160083PMC
September 2018
7 Reads

Ado-Trastuzumab Emtansine-Induced Pulmonary Toxicity: A Single-Institution Retrospective Review.

Case Rep Oncol 2018 May-Aug;11(2):527-533. Epub 2018 Aug 9.

University of Michigan Rogel Cancer Center, Ann Arbor, Michigan, USA.

Purpose: T-DM1 is an antibody drug conjugate with proven efficacy in metastatic breast cancer for progressive disease refractory to trastuzumab. Drug-induced pneumonitis is a rare serious potential adverse effect. The purpose of this review was to estimate the incidence of pulmonary toxicity at our institution. Read More

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http://dx.doi.org/10.1159/000491574DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6120401PMC
August 2018
6 Reads

Resolution of Crizotinib-Associated Fulminant Hepatitis following Cessation of Treatment.

Case Reports Hepatol 2018 5;2018:3413592. Epub 2018 Aug 5.

Department of Medicine, Division of Gastroenterology and Hepatology, Stanford University School of Medicine, Stanford, CA 94305, USA.

Targeted cancer treatments offer the prospect of precise inhibition of tumor growth without the untoward off-target toxicity of traditional chemotherapies. Still, unintended, often idiosyncratic side effects, such as drug-induced liver injury, can occur. We discuss the case of a 26-year-old female with a history of -rearranged lung adenocarcinoma, undergoing treatment with the tyrosine kinase inhibitor crizotinib, who presented to our hospital with abdominal pain and scleral icterus. Read More

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http://dx.doi.org/10.1155/2018/3413592DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6098865PMC
August 2018
2 Reads

Cancer therapeutics-related cardiac dysfunction in a patient treated with abiraterone for castration-resistant prostate cancer.

J Med Ultrason (2001) 2018 Aug 27. Epub 2018 Aug 27.

Department of Cardiology, Federation of National Public Service Personnel Mutual Aid Association Tachikawa Hospital, 4-2-22, Nishiki, Tachikawa, Tokyo, 190-8531, Japan.

Abiraterone is an agent effective for castration-resistant prostate cancer, but there have been no reports of cardiotoxic effects inducing cardiomyopathy, to our knowledge. We present a case of an 86-year-old man with castration-resistant prostate cancer treated with abiraterone. He had received an androgen receptor antagonist (bicalutamide) and a gonadotropin-releasing hormone antagonist (degarelix) for 3 years. Read More

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http://link.springer.com/10.1007/s10396-018-0897-7
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http://dx.doi.org/10.1007/s10396-018-0897-7DOI Listing
August 2018
9 Reads

CHST3 and CHST13 polymorphisms as predictors of bosentan-induced liver toxicity in Japanese patients with pulmonary arterial hypertension.

Pharmacol Res 2018 Sep 15;135:259-264. Epub 2018 Aug 15.

Laboratory of Clinical Pharmaceutical Science, Kobe Pharmaceutical University, 4-19-1 Motoyama-kitamachi, Higashinada, Kobe 658-8558, Japan; Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe Graduate School of Medicine, 7-5-1 Kusunoki, Chuo, Kobe 650-0017, Japan. Electronic address:

Bosentan, an endothelin receptor antagonist, has been widely used as a first-line drug for the treatment of pulmonary arterial hypertension (PAH). In addition, bosentan is approved for patients with digital ulcers related to systemic sclerosis. Liver dysfunction is a major adverse effect of bosentan and may lead to discontinuation of therapy. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10436618183041
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http://dx.doi.org/10.1016/j.phrs.2018.08.011DOI Listing
September 2018
10 Reads

Nitrofurantoin: friend or foe?

BMJ Case Rep 2018 Aug 16;2018. Epub 2018 Aug 16.

Internal Medicine, St Joseph Mercy Oakland, Pontiac, Michigan, USA.

Nitrofurantoin remains the gold standard treatment of uncomplicated cystitis as well as prophylactic treatment of recurrent urinary tract infections. Drug-induced hepatotoxicity presents in acute (3 in 1 000 000) and chronic (1 in 1500) forms. We present a patient with acute liver failure after 5 days of treatment. Read More

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http://dx.doi.org/10.1136/bcr-2018-225629DOI Listing
August 2018
9 Reads

Expression of caspase 1 and histomorphology of lung after cladribine treatment.

Adv Clin Exp Med 2018 Aug 6. Epub 2018 Aug 6.

Department of Histology and Embryology with Experimental Cytology Unit, Medical University of Lublin, Poland.

Background: Cladribine is a useful immunosuppressive drug for the treatment of autoimmune diseases, leukemias and multiple sclerosis (MS). Despite the drug having low toxicity, side effects have been reported connected with myelosuppression, neutropenia and severe anemia.

Objectives: The objective of this study was to investigate the influence of cladribine on lung pathomorphology and the expression of caspase 1 using immunohistochemistry method. Read More

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http://dx.doi.org/10.17219/acem/76253DOI Listing
August 2018
12 Reads

NF-κB and AMPK/PI3K/Akt signaling pathways are involved in the protective effects of Platycodon grandiflorum saponins against acetaminophen-induced acute hepatotoxicity in mice.

Phytother Res 2018 Nov 24;32(11):2235-2246. Epub 2018 Jul 24.

College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun, China.

Acute liver injury (ALI) induced by acetaminophen (APAP) overdose is the most common cause of drug-induced liver injury. Saponins from Platycodon grandiflorum (PGSs) ameliorate alcohol-induced hepatotoxicity and enhance human lung carcinoma cell death via AMPK signaling pathway. However, whether PGS could protect from APAP-induced ALI through AMPK activation and its downstream signals is still poorly elucidated. Read More

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http://dx.doi.org/10.1002/ptr.6160DOI Listing
November 2018
3 Reads
2.400 Impact Factor

Vinorelbine-induced acute respiratory distress syndrome treated with non-invasive ventilation and immunosuppressive therapy.

Respirol Case Rep 2018 Oct 17;6(7):e00349. Epub 2018 Jul 17.

Intensive Medicine Department São João Hospital Center Porto Portugal.

Severe drug-induced lung disease, resistant to steroids, is a dramatic situation due to the absence of therapeutic alternatives. We describe a case of vinorelbine-induced acute respiratory distress syndrome that did not respond to supportive care plus high-dose steroids. Cyclophosphamide pulse therapy was initiated with subsequent clinical and radiological improvement, allowing the patient to be discharged. Read More

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http://dx.doi.org/10.1002/rcr2.349DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6050163PMC
October 2018
2 Reads

Monoclonal antibody targeting of fibroblast growth factor receptor 1c causes cardiac valvulopathy in rats.

Toxicol Appl Pharmacol 2018 Sep 2;355:147-155. Epub 2018 Jul 2.

Bioscience Diabetes, IMED Biotech Unit, AstraZeneca, Gothenburg, Sweden.

Fibroblast Growth Factors (FGFs) and their receptors (FGFRs) have been proposed as potential drug targets for the treatment of obesity. The aim of this study was to assess the potential toxicity in rats of three anti-FGFR1c mAbs with differential binding activity prior to clinical development. Groups of male rats received weekly injections of either one of two FGFR1c-specific mAbs or an FGFR1c/FGFR4-specific mAb at 10 mg/kg for up to 4 weeks. Read More

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http://dx.doi.org/10.1016/j.taap.2018.06.033DOI Listing
September 2018
7 Reads

Non-toxic and non teratogenic extract of Thuja orientalis L. inhibited angiogenesis in zebra fish and suppressed the growth of human lung cancer cell line.

Biomed Pharmacother 2018 Oct 11;106:699-706. Epub 2018 Jul 11.

Department of Biotechnology, Karunya Institute of Technology and Sciences, Coimbatore, India.

Lung cancer is a malignant tumour with minimal survival rate and the current treatments are not showing complete remission of tumour and have many side effects. Thus a natural herbal medicine with good anti-cancer properties is highly demanded. Thuja orientalis L. Read More

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http://dx.doi.org/10.1016/j.biopha.2018.07.010DOI Listing
October 2018
1 Read
2.023 Impact Factor

Hepatotoxicity induced by paclitaxel interaction with turmeric in association with a microcystin from a contaminated dietary supplement.

Toxicon 2018 Aug 29;150:207-211. Epub 2018 May 29.

Observatory of Herb-Drug Interactions/Faculty of Pharmacy, University of Coimbra, Portugal; CQ - Centre of Chemistry - Faculdade de Ciências e Tecnologia, Rua Larga, University of Coimbra, Portugal. Electronic address:

A 67-year-old Caucasian male with lung cancer was presented to the Emergency Department with asthenia, anorexia, jaundice and choluria. The patient's lung cancer was being treated medically by a combination of paclitaxel/carboplatin with bi-monthly frequency. The patient was also self-medicating with several natural products, including Chlorella (520 mg/day), Silybum marianum (total of 13. Read More

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http://dx.doi.org/10.1016/j.toxicon.2018.05.022DOI Listing
August 2018
1 Read

Amiodarone-induced hepatic and pulmonary toxicity.

Postgrad Med J 2018 Oct 9;94(1116):603. Epub 2018 May 9.

Department of Internal Medicine, National Taiwan University Hospital Hsin-Chu Branch, Hsinchu, Taiwan.

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http://dx.doi.org/10.1136/postgradmedj-2018-135779DOI Listing
October 2018
1 Read

Elotuzumab-induced interstitial lung disease: the first case report.

Jpn J Clin Oncol 2018 May;48(5):491-494

Department of Pulmonary Medicine and Oncology, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan.

Elotuzumab, a humanized immunoglobulin G1 monoclonal antibody targeted against signaling lymphocytic activation molecule F7 (SLAMF7), has recently been used in combination with lenalidomide and dexamethasone for the treatment of patients with relapsed or refractory multiple myeloma. The clinical characteristics of drug-induced interstitial lung disease (ILD) due to elotuzumab have not been clarified. In this report, we describe a patient with refractory multiple myeloma who received elotuzumab in combination with lenalidomide and dexamethasone in whom fatigue, fever and diffuse pulmonary infiltration developed. Read More

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http://dx.doi.org/10.1093/jjco/hyy049DOI Listing
May 2018
3 Reads

Iatrogenic pulmonary lesions.

Semin Diagn Pathol 2018 Jul 23;35(4):260-271. Epub 2018 Mar 23.

Service de Pneumologie et Soins Intensifs Respiratoires, Hopital du Bocage Centre Hospitalier Universitaire (CHU) de Bourgogne, Dijon, France; UFR des Sciences de Santé, Université de Bourgogne, Dijon, France; INSERM U866, Faculté de Médecine, Dijon, France.

Treatment of patients often includes the administration of medications and sometimes radiation. While the intent is to treat an underlying condition, in some cases, adverse effects occur due to these agents. Most of these adverse effects are mild, however, some can be severe and life-threatening. Read More

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http://dx.doi.org/10.1053/j.semdp.2018.03.002DOI Listing
July 2018
16 Reads

Liver toxicity associated with tuberculosis chemotherapy in the REMoxTB study.

BMC Med 2018 03 28;16(1):46. Epub 2018 Mar 28.

University of St Andrews Medical School, St Andrews, UK.

Background: Drug-induced liver injury (DILI) is a common complication of tuberculosis treatment. We utilised data from the REMoxTB clinical trial to describe the incidence of predisposing factors and the natural history in patients with liver enzyme levels elevated in response to tuberculosis treatment.

Methods: Patients received either standard tuberculosis treatment (2EHRZ/4HR), or a 4-month regimen in which moxifloxacin replaced either ethambutol (isoniazid arm, 2MHRZ/2MHR) or isoniazid (ethambutol arm, 2EMRZ/2MR). Read More

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http://dx.doi.org/10.1186/s12916-018-1033-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5875008PMC
March 2018
7 Reads

An unexpected diagnosis in a patient with new-onset pulmonary infiltrates during adjuvant therapy for breast cancer.

Oxf Med Case Reports 2018 Feb 9;2018(2):omx095. Epub 2018 Feb 9.

Department of Nuclear Medicine, Hospital Universitario de Gran Canaria Dr Negrin, c/ Barranco de la Ballena s/n, 35010 Las Palmas de Gran Canaria, Spain.

The differential diagnosis of new-onset pulmonary infiltrates during adjuvant therapy in a cancer patient is challenging. Opportunistic infections, pulmonary drug-induced toxicity and metastatic dissemination of the underlying cancer are the most common causes. However, although infrequent, the development of a second primary pulmonary neoplasia should be taken into account. Read More

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http://dx.doi.org/10.1093/omcr/omx095DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5806405PMC
February 2018
2 Reads

Endothelial Cell-Specific Molecule-1 in Critically Ill Patients With Hematologic Malignancy.

Crit Care Med 2018 Mar;46(3):e250-e257

Medical Intensive Care Unit, Saint-Louis Hospital, Assistance Publique des Hôpitaux de Paris, Paris Diderot University, Paris, France.

Objectives: To assess whether serum concentration of endothelial cell-specific molecule-1 (Endocan) at ICU admission is associated with the use of ICU resources and outcomes in critically ill hematology patients.

Design: Prospective multicenter cohort study.

Setting: Seventeen ICUs in France and Belgium. Read More

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http://dx.doi.org/10.1097/CCM.0000000000002934DOI Listing
March 2018
27 Reads

CdS nanoparticles of different lengths induce differential responses in some of the liver functions of mice.

Bratisl Lek Listy 2018 ;119(2):75-80

Cadmium sulfide nanoparticles (CdS NPs) are one of important nanoparticle materials which are widely used in photoelectric production, but their potential health hazard to the liver is not clear. This study is aimed at exploring the possible mechanisms of liver injury induced by CdS NPs. Male mice were treated with nanoparticles of 110-130 nm and 80-100 nm cadmium sulfide. Read More

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http://dx.doi.org/10.4149/BLL_2018_014DOI Listing
June 2018
7 Reads

Oxidative imbalance in mice intoxicated by microcystin-LR can be minimized.

Toxicon 2018 Mar 16;144:75-82. Epub 2018 Feb 16.

Laboratory of Respiration Physiology, Carlos Chagas Filho Institute of Biophysics, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil. Electronic address:

Microcystins-LR (MC-LR) is a cyanotoxin produced by cyanobacteria. We evaluated the antioxidant potential of LASSBio-596 (LB-596, inhibitor of phosphodiesterases 4 and 5), per os, and biochemical markers involved in lung and liver injury induced by exposure to sublethal dose of MC-LR. Fifty male Swiss mice received an intraperitoneal injection of 60 μL of saline (CTRL group, n = 20) or a sublethal dose of MC-LR (40 μg/kg, TOX group, n = 20). Read More

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http://dx.doi.org/10.1016/j.toxicon.2018.02.008DOI Listing
March 2018
4 Reads

Drug-induced eosinophilic pneumonia: A review of 196 case reports.

Medicine (Baltimore) 2018 Jan;97(4):e9688

Background And Objective: Eosinophilic pneumonia (EP) is an important subset of patients who present with pulmonary infiltrates and eosinophilia (PIE). EP is classified by chronicity and etiology and drug-induced EP is the main cause of secondary EP. The primary goal of this review was to examine all the case reports published since the syndrome was defined in 1990. Read More

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http://dx.doi.org/10.1097/MD.0000000000009688DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5794373PMC
January 2018
21 Reads

Spontaneous resolution of nitrofurantoin-induced chronic pulmonary toxicity presenting with respiratory failure.

Adv Respir Med 2017 ;85(6):333-338

SKIMS Medical College, Bemina, 190018 Srinagar, India.

Nitrofurantoin is one of the most common drugs implicated in drug-induced pulmonary toxicities, the manifestations of which range from dose-independent acute self-limiting reactions to chronic dose-dependent pathologies. The severity of these pulmonary adverse effects may range from trivial hypersensitivity reactions to extensive and irreversible lung fibrosis leading to respiratory failure and death. Symptomatic and supportive treatment in addition to discontinuation of the drug usually suffices for the management of mild reactions. Read More

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https://journals.viamedica.pl/advances_in_respiratory_medici
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http://dx.doi.org/10.5603/ARM.2017.0057DOI Listing
September 2018
2 Reads

Association between effectiveness of tuberculosis treatment and cytochrome P-4502E1 polymorphism of the patients.

Int J Mycobacteriol 2017 Oct-Dec;6(4):396-400

Department of Internal Medicine, Kharkiv National Medical University; Department of Internal Medicine, V. N. Karazin Kharkiv National University, Kharkiv, Ukraine.

Context: The risk of antituberculosis (TB) drug-induced liver injury could be determined by patients' genotype polymorphism of the xenobiotic-metabolizing enzymes. To find the meaning of cytochrome P-4502E1 (CYP2E1) polymorphism in TB patients. Corresponding of CYP2E1 polymorphism in TB patients with the level of isoniazid and rifampicin as well as for the outcome and toxicity development during inpatient TB treatment. Read More

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http://dx.doi.org/10.4103/ijmy.ijmy_168_17DOI Listing
September 2018
4 Reads

Drug-induced eosinophilic pneumonia in a patient with Crohn's disease: diagnosis and treatment using fraction of exhaled nitric oxide.

Intest Res 2017 Oct 23;15(4):529-534. Epub 2017 Oct 23.

Department of Internal Medicine, Gachon University Gil Medical Center, Incheon, Korea.

Oral 5-aminosalicylic acid agents (mesalazine and sulfasalazine) and azathioprine are the mainstays of treatment for inflammatory bowel disease. Reports of pulmonary toxicity induced by oral 5-aminosalicylic acid agents or azathioprine in patients with inflammatory bowel disease are very rare; to date, only 38 cases have been reported worldwide. We, herein, report a case involving a 26-year-old man who was diagnosed with eosinophilic pneumonia after using mesalazine and azathioprine for the treatment of Crohn's disease and recovered after treatment. Read More

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http://dx.doi.org/10.5217/ir.2017.15.4.529DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5683985PMC
October 2017
16 Reads

The exposure-effect-toxicity correlation of docetaxel and magnesium isoglycyrrhizinate in non-small cell lung tumor-bearing mice.

Biomed Pharmacother 2018 Jan 8;97:1000-1010. Epub 2017 Nov 8.

Key Lab of Drug Metabolism & Pharmacokinetics, China Pharmaceutical University, Nanjing 210009, China, China. Electronic address:

To take full advantage of combination therapy of Docetaxel (DTX) and Magnesium isoglycyrrhizinate (MGIG), the pharmacokinetic- pharmacodynamic- toxicodynamics (PK-PD-TD) interaction of DTX and MGIG in non-small cell lung tumor-bearing mice was investigated in the present study. A model, an integrated semi-mechanistic PK-PD-TD, was established for elucidating the exposure-effect-toxicity relationship between DTX and MGIG. A tumor growth and a transit compartmental system were applied to imitate the growth and death of tumor cell. Read More

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http://dx.doi.org/10.1016/j.biopha.2017.10.158DOI Listing
January 2018
36 Reads

Development of interstitial pneumonia during treatment with eribulin: a case report.

BMC Res Notes 2017 Nov 6;10(1):557. Epub 2017 Nov 6.

Department of Respiratory Medicine, Juntendo University Graduate School of Medicine, 3-1-3, Hongo, Bunkyo-ku, Tokyo, 113-8431, Japan.

Background: Eribulin is typically used to treat patients with advanced breast cancer, and anti-cancer agents often cause the development of interstitial pneumonia in Japanese patients with advanced cancer. However, few case reports have addressed eribulin-induced interstitial pneumonia. Herein, we report a rare case of interstitial pneumonia-specifically, organized pneumonia-during treatment with eribulin in a patient with advanced breast cancer. Read More

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http://dx.doi.org/10.1186/s13104-017-2882-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5674230PMC
November 2017
12 Reads

LIVER FUNCTION DISORDERS IN PATIENTS WITH FIRST DIAGNOSED PULMONARY TUBERCULOSIS.

Georgian Med News 2017 Oct(271):49-55

I.HorbachevskyTernopil State Medical University, Ternopil; Ternopil Regional TB Dispensary, Ukraine.

The patients with pulmonary tuberculosis suffer from hepatic dysfunction due to both hepatotoxic affection with anti-TB drugs and other factors (hypoxia, antioxidant deficiency, intoxication). Therefore, the aim of the research was to study the markers of cytolytic and cholestatic syndromes in cases of hepatic dysfunction in the first diagnosed patients with pulmonary tuberculosis before treatment and in two months of treatment with first-line antituberculous drugs. Three groups of persons were examined: the first group of almost healthy donors (control) - 31 persons. Read More

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October 2017
8 Reads

Association and clinical utility of NAT2 in the prediction of isoniazid-induced liver injury in Singaporean patients.

PLoS One 2017 16;12(10):e0186200. Epub 2017 Oct 16.

Translational Laboratory in Genetic Medicine, Agency for Science, Technology and Research, Singapore and the National University of Singapore, Singapore.

Background And Aims: Isoniazid (INH) is part of the first-line-therapy for tuberculosis (TB) but can cause drug-induced liver injury (DILI). Several candidate single nucleotide polymorphisms (SNPs) have been previously identified but the clinical utility of these SNPs in the prediction of INH-DILI remains uncertain. The aim of this study was to assess the association between selected candidate SNPs and the risk of INH-DILI and to assess the clinical validity of associated variants in a Singaporean population. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0186200PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5642896PMC
October 2017
34 Reads

Prognostic value of serum zinc levels in patients with acute HC/zinc chloride smoke inhalation.

Medicine (Baltimore) 2017 Sep;96(39):e8156

Department of Pulmonary and Critical Care Medicine, Chinese PLA General Hospital, Beijing, China.

Hexachloroethane (HC)/zinc chloride (ZnCl, smoke bomb) exposure in the military setting results in lung injury which is uncommon and has been rarely described in previous studies. The aim of this study is to investigate the correlation between the serum zinc in patients with HC/ZnCl smoke inhalation lung injury and disease severity. A total of 15 patients with HC/ZnCl-related conditions were recruited in this study. Read More

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http://dx.doi.org/10.1097/MD.0000000000008156DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5626303PMC
September 2017
6 Reads

Prognosis and treatment of FOLFOX therapy related interstitial pneumonia: a plea for multimodal immune modulating therapy in the respiratory insufficient patient.

BMC Cancer 2017 Aug 29;17(1):586. Epub 2017 Aug 29.

Department of Intensive Care Medicine, Antwerp University Hospital, University of Antwerp, Wilrijkstraat 10, 2650, Edegem, Belgium.

Background: The FOLFOX regimen, i.e., folinic acid (FOL), fluorouracil (F) and oxaliplatin (OX), is a drug cocktail that is used to treat gastric and colorectal cancers. Read More

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http://dx.doi.org/10.1186/s12885-017-3576-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5576105PMC
August 2017
13 Reads

Methyl pyruvate protects a normal lung fibroblast cell line from irinotecan-induced cell death: Potential use as adjunctive to chemotherapy.

PLoS One 2017 10;12(8):e0182789. Epub 2017 Aug 10.

Department of Life & Consumer Sciences, 211 Calabash Building, University of South Africa, Florida, Johannesburg, Republic of South Africa.

The Warburg Effect, characterized by increased rate of glycolysis even under normoxic conditions, is one of the hallmarks of cancer. Relatively lower oxidative phosphorylation (OXPHOS) is also a characteristic feature in cancer cells. We hypothesized that interference with this phenomenon, by introducing exogenous pyruvate, would upset this cancer phenotype and boost the energy requirements of normal cells. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0182789PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5552298PMC
October 2017
6 Reads

Lung cancer as a cardiotoxic state: a review.

Med Oncol 2017 Aug 9;34(9):159. Epub 2017 Aug 9.

Medical Oncology Department, Hospital Universitario Puerta de Hierro Majadahonda, C/Manuel de Falla 1, 28222, Majadahonda, Madrid, Spain.

As the overall survival of patients with lung cancer continues to increase, more cancer survivors are faced with the risk of developing treatment-related cardiovascular toxicities. The increased knowledge of the molecular biology of non-small cell lung cancer has led to new and more personalized treatments. Nevertheless, the usual chemotherapy schemes and radiation therapy induce cardiac toxicities that are frequently underappreciated or go unnoticed. Read More

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http://dx.doi.org/10.1007/s12032-017-1012-4DOI Listing
August 2017
14 Reads

Use of Human Pluripotent Stem Cell Derived-Cardiomyocytes to Study Drug-Induced Cardiotoxicity.

Curr Protoc Toxicol 2017 Aug 4;73:22.5.1-22.5.22. Epub 2017 Aug 4.

Translational Laboratory in Genetic Medicine, Agency for Science Technology and Research, Singapore.

Drug-induced cardiotoxicity is the one of the most common causes of drug withdrawal from market. A major barrier in managing the risk of drug-induced cardiotoxicity has been the lack of relevant models to study cardiac safety. Human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) have great potential in drug discovery and cardiotoxcity screens as they display many characteristics of the human myocardium and offer unlimited supply. Read More

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http://dx.doi.org/10.1002/cptx.30DOI Listing
August 2017
2 Reads

Lycopene Prevents Mitochondrial Dysfunction during d-Galactosamine/Lipopolysaccharide-Induced Fulminant Hepatic Failure in Albino Rats.

J Proteome Res 2017 09 21;16(9):3190-3199. Epub 2017 Aug 21.

Bioinformatics and High Performance Computing Research Group (BIO-HPC), Computer Engineering Department, Universidad Católica San Antonio de Murcia (UCAM) , Guadalupe, 30107 Murcia, Spain.

Functional perturbation of mitochondria is associated with fulminant hepatic failure (FHF). d-Galactosamine/lipopolysaccharide (d-GalN/LPS)-induced FHF is a renowned model to evaluate the efficacy of hepatoprotective agents. Lycopene is an antioxidant and phytonutrient from the carotenoid family. Read More

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http://pubs.acs.org/doi/10.1021/acs.jproteome.7b00176
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http://dx.doi.org/10.1021/acs.jproteome.7b00176DOI Listing
September 2017
2 Reads

Solid lipid nanoparticles improve octyl gallate antimetastatic activity and ameliorate its renal and hepatic toxic effects.

Anticancer Drugs 2017 10;28(9):977-988

aDepartment of Pharmaceutical Sciences bDepartment of Biochemistry cDepartment of Chemistry, Federal University of Santa Catarina dNanovetores Technology S.A., Florianópolis eUniversity of Western Santa Catarina, Videira, SC fFederal University of Tocantins, Araguaína, TO, Brazil.

Metastasis is the main cause of cancer-related death and requires the development of effective treatments with reduced toxicity and effective anticancer activity. Gallic acid derivatives have shown significant biological properties including antitumoral activity as shown in a previous study with octyl gallate (G8) in vitro. Thus, the aim of this work was to evaluate the antimetastatic effect of free and solid lipid nanoparticle-loaded G8 in mice in a lung metastasis model. Read More

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http://dx.doi.org/10.1097/CAD.0000000000000539DOI Listing
October 2017
13 Reads
1.891 Impact Factor

Pharmacological Threat to Lungs: A Case Series and Literature Review.

Cureus 2017 May 9;9(5):e1232. Epub 2017 May 9.

Pulmonology, The Aga Khan University.

Drug-induced organ damage stands as a prevalent yet much-neglected issue globally. Keeping in view it's rising frequency, health care providers stand obliged to be well versed with the de-merits of the agents they prescribe. Drug therapies causing damage present with a non-specific clinical presentation, histological findings or radiology, which further elaborates on the necessity of a conscientious diagnosis. Read More

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http://dx.doi.org/10.7759/cureus.1232DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5467773PMC
May 2017
2 Reads

Lutein mitigates cyclophosphamide induced lung and liver injury via NF-κB/MAPK dependent mechanism.

Biomed Pharmacother 2017 Aug 30;92:519-527. Epub 2017 May 30.

Department of Pharmacology and Toxicology, College of Pharmacy, Taibah University, Al-Madinah Al-Munawwarah, 30001, Saudi Arabia; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Mansoura University, Mansoura, 35516, Egypt.

This study targeted to test the potential protective role of lutein against lung and liver damage associated with cyclophosphamide (CP) administration. Lutein was given orally for 5days at two different doses both before and after CP injection. Results have shown that CP administration caused marked pulmonary and hepatic injurious effects in mice. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07533322173096
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http://dx.doi.org/10.1016/j.biopha.2017.05.103DOI Listing
August 2017
14 Reads
1 Citation
2.023 Impact Factor

A Comparative Benchmark Dose Study for N, N-Dimethylformamide Induced Liver Injury in a Chinese Occupational Cohort.

Toxicol Sci 2017 07;158(1):140-150

The Toxicology Laboratory of National Institute for Occupational Health and Poison Control, Chinese Center for Disease Control and Prevention, Beijing 100050, China.

Widespread contamination of N,N-dimethylformamide (DMF) has been identified in the environment of leather industries and their surrounding residential areas. Few studies have assessed the dose-response relationships between internal exposure biomarkers and liver injury in DMF exposed populations. We assessed urinary N-methylformamide (NMF) and N-acetyl-S-(N-methylcarbamoyl) cysteine (AMCC) and blood N-methylcarbmoylated hemoglobin (NMHb) levels in 698 Chinese DMF-exposed workers and 188 nonDMF- exposed workers using ultraperformance liquid-chromatography tandem mass-spectrometry. Read More

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http://dx.doi.org/10.1093/toxsci/kfx076DOI Listing
July 2017
35 Reads

High sensitivity of testicular function to titanium nanoparticles.

J Toxicol Sci 2017 ;42(3):359-366

Laboratory of Molecular and Biochemical Toxicology, Graduate School of Pharmaceutical Sciences, Tohoku University.

Titanium dioxide nanoparticles (TiNPs) present toxicity in organs such as the liver, lung, and intestine. The testis has also been reported as a target organ of TiNPs. We recently reported that TiNPs had no genotoxic effect in the liver and bone marrow, while showing clear testicular dysfunction. Read More

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http://dx.doi.org/10.2131/jts.42.359DOI Listing
October 2017
23 Reads

Maintenance of high quality rat precision cut liver slices during culture to study hepatotoxic responses: Acetaminophen as a model compound.

Toxicol In Vitro 2017 Aug 2;42:200-213. Epub 2017 May 2.

Fraunhofer Institute for Toxicology and Experimental Medicine (ITEM), Member of the German Center for Lung Research (DZL), Biomedical Research in End Stage and Obstructive Lung Disease (BREATH) Research Network, Member of the Cluster of Excellence Regenerative Biology to Reconstructive Therapy (REBIRTH), Nikolai-Fuchs-Straße 1, 30625 Hannover, Germany. Electronic address:

Precision cut liver slices (PCLiS) represent a promising tool in reflecting hepatotoxic responses. However, the culture of PCLiS varies considerably between laboratories, which can affect the performance of the liver slices and thus the experimental outcome. In this study, we describe an easily accessible culture method, which ensures optimal slice viability and functionality, in order to set the basis for reproducible and comparable PCLiS studies. Read More

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http://dx.doi.org/10.1016/j.tiv.2017.05.001DOI Listing
August 2017
6 Reads

Preclinical studies for the combination of paclitaxel and curcumin in cancer therapy (Review).

Oncol Rep 2017 Jun 20;37(6):3159-3166. Epub 2017 Apr 20.

Department of Pharmaceutics, School of Pharmacy, Southwest Medical University, Luzhou, Sichuan 646099, P.R. China.

Cancer is one of the most common causes of death and remains the first in China and the second in the US. The common treatments for cancer include surgery, radiation, chemotherapy, targeted therapy and immunotherapy, while chemotherapy remains one of the most important treatments. However, the efficacy of chemotherapy is limited due to drug induced-toxicities and resistance, particularly multiple drug resistance (MDR). Read More

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http://dx.doi.org/10.3892/or.2017.5593DOI Listing
June 2017
11 Reads

New drugs, new toxicities: severe side effects of modern targeted and immunotherapy of cancer and their management.

Crit Care 2017 04 14;21(1):89. Epub 2017 Apr 14.

General Hospital Department of Medicine I, Medical University of Vienna, Vienna, Austria.

Pharmacological and cellular treatment of cancer is changing dramatically with benefits for patient outcome and comfort, but also with new toxicity profiles. The majority of adverse events can be classified as mild or moderate, but severe and life-threatening complications requiring ICU admission also occur. This review will focus on pathophysiology, symptoms, and management of these events based on the available literature. Read More

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http://dx.doi.org/10.1186/s13054-017-1678-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5391608PMC
April 2017
4 Reads

Hepatotoxicity associated to synthetic cannabinoids use.

Eur Rev Med Pharmacol Sci 2017 03;21(1 Suppl):1-6

Department of Therapeutic Research and Medicines Evaluation, Drug Abuse and Doping Unit, Istituto Superiore di Sanità, Rome, Italy.

Synthetic cannabinoids (SCs) are psychotropic compounds, chemically created in laboratory to mimic cannabinergic brain activity of delta-9 tetrahydrocannabinol. The consumption of these compounds for recreational purposes can lead to a variety of adverse effects on health including overdose and deaths. Increasingly popular as substances of abuse since the 2000s, SCs were produced initially to bind and study cannabinoid receptors (they also can be called synthetic cannabimimetics) failing in eliminating the psychoactive effects. Read More

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March 2017
4 Reads

How Common Are Pulmonary and Hepatic Adverse Effects in Older Adults Prescribed Nitrofurantoin?

J Am Geriatr Soc 2017 Jun 17;65(6):1316-1320. Epub 2017 Mar 17.

Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas.

Objectives: To determine the frequency of serious pulmonary and hepatic adverse events (AEs) in persons aged 65 and older prescribed nitrofurantoin.

Design: Retrospective electronic health record (EHR) audit of nitrofurantoin prescriptions and associated AEs.

Setting: Urban academic medical center. Read More

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http://dx.doi.org/10.1111/jgs.14796DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5478436PMC
June 2017
4 Reads