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    221 results match your criteria Drug-Induced Photosensitivity

    1 OF 5

    Drug-induced photosensitivity: Photoallergic and phototoxic reactions.
    Clin Dermatol 2016 Sep-Oct;34(5):571-81. Epub 2016 May 20.
    Department of Dermatovenereology, Hospital Distrital de Santarém EPE, Santarém, Portugal.
    Drug-induced photosensitivity refers to the development of cutaneous disease due to the interaction between a given chemical agent and sunlight. Photosensitivity reactions can be classified as phototoxic or photoallergic. Sometimes, there is an overlap between these two patterns, making their distinction particularly difficult for the clinician. Read More

    Drug-induced photosensitivity: new insights into pathomechanisms and clinical variation through basic and applied science.
    Br J Dermatol 2016 Aug 11. Epub 2016 Aug 11.
    Betsi Cadwaladr University Health Board, Ysbyty Gwynedd, Penrhosgarnedd, Bangor, Gwynedd, LL57 2PY, U.K.
    Drug-induced photosensitivity occurs when a drug is capable of absorbing radiation from the sun (usually UVA) leading to chemical reactions that cause cellular damage (phototoxicity) or, more rarely, form photoallergens (photoallergy). The manifestation varies considerably in presentation and severity from mild pain to severe blistering. Despite screening strategies and guidelines in place to predict photoreactive drugs during development there are still new drugs coming on the market that cause photosensitivity. Read More

    Update on treatment of photodermatosis.
    Dermatol Online J 2016 Feb 17;22(2). Epub 2016 Feb 17.
    First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu.
    Photodermatoses are a group of skin conditions associated with an abnormal reaction to ultraviolet (UV) radiation. There are several of the photosensitive rashes which mainly affect the UV exposed areas of the skin. It can be classified into four groups: immunology mediated photodermatoses, chemical and drug induced photosensitivity, photoaggravated dermatoses, and genetic disorders. Read More

    Knowledge about Ultraviolet Radiation Hazards and Tanning Behavior of Cosmetology and Medical Students.
    Acta Dermatovenerol Croat 2016 Apr;24(1):73-7
    Ewelina Bogumiła Zuba, MD, Medical University of Poznan, 49 Przybyszewskiego St, 60-355 Poznan, Poland;
    Dear Editor, Ultraviolet (UV) radiation is a well-known physical hazard responsible for photoaging, photoallergic, and phototoxic reactions as well as carcinogenesis, including life-threatening melanomas (1,2). Overexposure to both natural and artificial UV radiation is a public health concern. 30% of cancers diagnosed worldwide are skin cancers. Read More

    Drug-induced Photosensitivity.
    Acta Dermatovenerol Croat 2016 Apr;24(1):55-64
    Ewelina Bogumiła Zuba MD, Medical University of Poznan, 49 Przybyszewskiego St, 60-355 Poznan, Poland;
    Ultraviolet radiation is considered the main environmental physical hazard to the skin. It is responsible for photoaging, sunburns, carcinogenesis, and photodermatoses, including drug-induced photosensitivity. Drug-induced photosensitivity is an abnormal skin reaction either to sunlight or to artificial light. Read More

    Diclofenac-Induced Photo-Onycholysis.
    Oman Med J 2016 Jan;31(1):65-8
    Department of Dermatology, Al Nahdha Hospital, Muscat, Oman.
    Onycholysis is the detachment of the nail plate from the nail bed. If drug-induced, it can be an isolated phenomenon, but it may also accompany or follow a cutaneous phototoxicity reaction due to drug intake and exposure to ultraviolet irradiation. Photo-onycholysis is a rare photosensitivity reaction due to exposure to either a natural or artificial source of light. Read More

    Molecular mechanisms of drug photodegradation and photosensitization.
    Curr Pharm Des 2016 ;22(7):768-82
    "GALLY" International Biomedical Research Consulting LLC, San Antonio, TX 78229, USA.
    Drug-induced photosensitivity of the skin is drawing increasing attention. In past few decades, photosensitivity has been reported with an array of drugs, and is now recognized as a noteworthy medical problem by clinicians, regulatory authorities and pharmaceutical industry. The photosensitivity is of two types i. Read More

    Secondary angle closure glaucoma by lupus choroidopathy as an initial presentation of systemic lupus erythematosus: a case report.
    BMC Ophthalmol 2015 Oct 29;15:148. Epub 2015 Oct 29.
    Department of Ophthalmology, Kyung Hee University Hospital at Gangdong, Kyung Hee University, 892, Dongnam-ro, Gangdong-gu, Seoul, 05278, Korea.
    Background: We present a rare case of secondary angle closure glaucoma due to systemic lupus erythematosus choroidopathy as initial presentation of systemic lupus erythematosus, accompanied by central nervous system vasculitis and uncontrolled nephropathy.

    Case Presentation: A 31-year-old woman presented with decreased visual acuity, nausea, vomiting, fever, and bilateral angioedema-like eyelid swelling. She had persistent dry cough while taking medication for 3 months, and had usual posterior neck pain, which was treated with analgesic medication and Asian medicines. Read More

    Drug-induced lupus with leukocytoclastic vasculitis: a rare expression associated with adalimumab.
    An Bras Dermatol 2015 May-Jun;90(3 Suppl 1):121-4
    University of Taubaté, Taubaté, SP, BR.
    TNF alpha antagonist-induced lupus-like syndrome is a rare condition which predominantly affects women (4:1). The average age of onset is 46-51 years. It occurs after exposure to TNF alpha antagonist and disappears after discontinuation of such agents. Read More

    Dialysis-associated pseudoporphyria successfully treated with vitamin D. Report of two cases.
    G Ital Dermatol Venereol 2015 Jun;150(3):327-9
    Unit of Dermatology, NESMOS Department, Faculty of Medicine, Sant'Andrea" Hospital "Sapienza" University, Rome, Italy -
    Pseudoporphyria refers to a rare bullous dermatosis characterized by the clinical and histological features of porfiria cutanea tarda without abnormalities in porphyrin metabolism. The pathogenesis is heterogeneous and several exogenous factors may promote the bullous lesion formation, including medications, end stage renal disease, dialysis and tanning beds. Regarding treatment of this condition, in literature different therapy have been reported, such as glutathione and his precursor N-acetylcysteine, which presents anti-oxidant properties; however even more toxic drugs, such as chloroquine, are used. Read More

    Drug-induced nail disorders.
    • Authors:
    Prescrire Int 2014 Jul;23(151):180-2
    Nail disorders are defined according to their appearance and the part of the nail affected: the nail plate, the tissues that support or hold the nail plate in place, or the lunula. The consequences of most nail disorders are purely cosmetic. Other disorders, such as ingrown nails, inflammation, erythema, abscesses or tumours, cause functional impairment or pain. Read More

    Drug-induced photosensitivity.
    Dermatol Clin 2014 Jul;32(3):363-8, ix
    Photobiology Unit, Department of Dermatology, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, Scotland, UK.
    Drug-induced photosensitivity is common. The principal mechanism of systemic drug photosensitivity is phototoxicity and the principal mechanism of topical drug photosensitivity is photoallergy. Photopatch testing is helpful to determine suspected topical agent photoallergies (eg, from ultraviolet filters in sunscreens) but generally not helpful in detecting systemic drug photosensitivity. Read More

    Epidemiology of cutaneous drug-induced reactions.
    G Ital Dermatol Venereol 2014 Apr;149(2):207-18
    Department of Dermatology Azienda Ospedaliera Papa Giovanni XXIII Bergamo, Italy -
    Cutaneous reactions represent in many surveillance systems, the most frequent adverse events attributable to drugs. The spectrum of clinical manifestations is wide and virtually encompasses any known dermatological disease. The introduction of biological agents and so-called targeted therapies has further enlarged the number of reaction patterns especially linked with cytokine release or in balance. Read More

    Serology of Lupus Erythematosus: Correlation between Immunopathological Features and Clinical Aspects.
    Autoimmune Dis 2014 6;2014:321359. Epub 2014 Feb 6.
    Di.S.Sal, Section of Dermatology, IRCCS Azienda Ospedaliera, Universitaria San Martino-IST, 16132 Genoa, Italy.
    Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the aberrant production of a broad and heterogenous group of autoantibodies. Even though the presence of autoantibodies in SLE has been known, for more than 60 years, still nowadays a great effort is being made to understand the pathogenetic, diagnostic, and prognostic meaning of such autoantibodies. Antibodies to ds-DNA are useful for the diagnosis of SLE, to monitor the disease activity, and correlate with renal and central nervous involvements. Read More

    Case of vemurafenib-induced Sweet's syndrome.
    J Dermatol 2014 Sep 12;41(9):817-20. Epub 2014 Mar 12.
    Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
    Vemurafenib is a targeted therapy that has become standard treatment for patients with advanced melanoma with a V600E BRAF mutation. It has been associated with frequent skin toxicity, including photosensitivity, rash and squamous cell carcinomas. We present an 83-year-old woman with an advanced V600E BRAF-mutant melanoma who developed a severe skin rash and fatigue after taking vemurafenib. Read More

    Drug-induced photoallergic and phototoxic reactions - an update.
    Expert Opin Drug Saf 2014 Mar;13(3):321-40
    New York Presbyterian Hospital, Weill Cornell Medical College, Department of Dermatology , New York, NY 10021 , USA
    Introduction: Photoallergic and phototoxic medications continue to be an important concern for dermatologists. In the last 5 years, the list of phototoxic and photoallergic medications has expanded, as well as the testing tools used to screen for potential allergy. Currently available testing methods include the photoprick, photoscratch and illuminated intracutaneous tests. Read More

    Third and fourth generation fluoroquinolone antibacterials: a systematic review of safety and toxicity profiles.
    Curr Drug Saf 2014 ;9(2):89-105
    Faculty of Health Sciences, University of Beira Interior, CICS-UBI - Health Sciences Research Centre, University of Beira Interior, Av. Infante D. Henrique, 6200-506 Covilha, Portugal.
    In the last decade, several third and fourth generation fluoroquinolones (FQs) have been approved for clinical use. These new agents exhibit a more potent and broader-spectrum antibacterial activity and improved pharmacokinetic properties in comparison to the earlier FQs. Although new FQs are generally safe and well tolerated, moderate-to-severe toxicity events have been reported for some of them, leading to their restriction, suspension or even withdrawal from the market. Read More

    Photo recall reaction following the use of vancomycin.
    Dermatol Online J 2013 Nov 15;19(11):20396. Epub 2013 Nov 15.
    University of Kansas School of Medicine.
    Drug-induced erythema in the distribution of prior sunburn is called photo recall. Although more commonly induced by chemotherapeutics, it has also been associated with antibiotics such as ampicillin, cephalosporin, and gentamicin. Vancomycin has not been previously reported as a causal agent. Read More

    Photodermatoses, including phototoxic and photoallergic reactions (internal and external).
    Clin Dermatol 2014 Jan-Feb;32(1):73-9
    Cerrahpaşa Medical Faculty, Department of Dermatology, İstanbul University, Fatih, İstanbul, 34098 Turkey. Electronic address:
    Photodermatoses are caused by an abnormal reaction mainly to the ultraviolet component of sunlight. Photodermatoses can be broadly classified into four groups: immunologically mediated photodermatoses, chemical- and drug-induced photosensitivity, photoaggravated dermatoses, and DNA repair-deficiency photodermatoses. In this review, we focus mainly on chemical- and drug-induced photosensitivity, namely, phototoxicity and photoallergy. Read More

    [Cutaneous adverse drug reaction: prospective study of 118 cases].
    Tunis Med 2013 Aug-Sep;91(8-9):514-20
    Background: Few prospective studies are available on the incidence and analysis of the characteristics of adverse cutaneous drug reactions.

    Aim: To describe the adverse cutaneous reactions, their epidemiologic characteristics as well as the different causative drugs through a prospective hospital study.

    Methods: A 12-month prospective study was managed in our department of dermatology of the teaching hospital Hedi Chaker of Sfax. Read More

    Epstein-Barr virus and skin manifestations in childhood.
    Int J Dermatol 2013 Oct;52(10):1177-84
    Unit of Dermatology, Arcispedale S. Maria Nuova-IRCCS, Reggio Emilia, Italy.
    Epstein-Barr virus (EBV) is a human B-lymphotropic herpes virus and one of the most common viruses in humans. Specific skin signs related to EBV infection are the exanthem of mononucleosis, which is observed more frequently after ingestion of amoxicillin, and oral hairy leukoplakia, a disease occurring mostly in immunocompromised subjects with HIV infection. Other more uncommon cutaneous disorders that have been associated with EBV infection include virus-related exanthems or diseases such as Gianotti-Crosti syndrome, erythema multiforme, and acute genital ulcers. Read More

    Photosensitivity due to thiazides.
    Actas Dermosifiliogr 2014 May 8;105(4):359-66. Epub 2013 May 8.
    Departamento de Dermatología, Complejo Hospitalario Universitario, Facultad de Medicina, Santiago de Compostela, España.
    Thiazides are widely used diuretics that first became available in the 1950s. The first reports of photosensitivity reactions to thiazides were published shortly after the introduction of these drugs, but few cases have been described since. We review all the cases of photosensitivity due to thiazides published up to December 2011. Read More

    Vemurafenib: an unusual UVA-induced photosensitivity.
    Exp Dermatol 2013 Apr;22(4):297-8
    Vemurafenib is a new-targeted therapy approved for the treatment of patients with V600E BRAF-mutant metastatic melanoma. Among the cutaneous adverse events reported, the photosensitivity is frequently experienced. We aimed to characterize more deeply the mechanism leading to this photosensitivity as well as the corresponding UV spectrum. Read More

    Sun exposure behavior and protection: recommendations for travelers.
    J Travel Med 2013 Mar-Apr;20(2):108-18. Epub 2012 Dec 4.
    Program in Environmental and Occupational Health Sciences, Schools of Public Health and Medicine, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA.
    Background: Although there have been recent advances in the development of photoprotective clothing and broad-spectrum sunscreens, few peer-reviewed publications have focused on photoprotection recommendations for travelers.

    Methods: In order to describe the adverse health effects of excessive ultraviolet (UV) radiation exposures; review recent studies of public perceptions regarding photoprotection and sun exposure behaviors; identify special populations at increased risks of drug-induced photosensitivity reactions and UV-induced skin cancers; and recommend several effective photoprotection strategies for travelers, Internet search engines were queried with the key words as search terms to examine the latest references on photoprotection and the epidemiology of UV-associated skin cancers.

    Results: Observational studies have demonstrated that the public knows little about proper sunscreen protection, selection, and use, and often abuses sunscreens for intentional UV overexposures. Read More

    Pityriasis rosea-like drug eruption due to nortriptyline in a patient with vulvodynia.
    J Low Genit Tract Dis 2013 Apr;17(2):226-9
    Section of Dermatology, Department of Medicine, Pritzker School of Medicine, The University of Chicago, Chicago, IL 60637, USA.
    Background: Nortriptyline and other tricyclic antidepressants are widely used in the treatment of depression. They are also used in chronic pain syndromes such as vulvodynia. We report a case of pityriasis rosea (PR)-like eruption in a young woman who was treated with oral nortriptyline for vulvodynia. Read More

    Drug-induced generalized skin eruption in a diabetes mellitus patient receiving a dipeptidyl peptidase-4 inhibitor plus metformin.
    Diabetes Ther 2012 Dec 6;3(1):14. Epub 2012 Nov 6.
    Division of Diabetes, Clinical Nutrition and Endocrinology, Department of Internal Medicine, Kasai Electric Power Hospital, 2-1-7 Fukushima, Fukushima Ward, Osaka City, 553-0003, Japan.
    A generalized skin eruption with strong itching was induced by sitagliptin, a dipeptidyl peptidase-4 (DPP-4) inhibitor, in a patient almost 6 months after initiation of the drug. Physical examination revealed a spread of skin rash from chest to back, and abdomen and thigh. Discontinuation of the drug eliminated the skin rash immediately. Read More

    Cutaneous lupus erythematosus: first multicenter database analysis of 1002 patients from the European Society of Cutaneous Lupus Erythematosus (EUSCLE).
    Autoimmun Rev 2013 Jan 18;12(3):444-54. Epub 2012 Sep 18.
    Department of Dermatology, University of Muenster, 48149 Muenster, Germany.
    In this prospective, cross-sectional, multicenter study, we assessed clinical and laboratory characteristics from patients with cutaneous lupus erythematosus (CLE) using the Core Set Questionnaire of the European Society of Cutaneous Lupus Erythematosus (EUSCLE). 1002 (768 females, 234 males) patients with different subtypes of CLE, such as acute CLE (ACLE, 304 patients), subacute CLE (SCLE, 236 patients), chronic CLE (CCLE, 397 patients), and intermittent CLE (ICLE, 65 patients), from 13 European countries were collected and statistically analyzed by an SPSS database. The main outcome measures included gender, age at onset of disease, LE-specific and LE-nonspecific skin lesions, photosensitivity, laboratory features, and the criteria of the American College of Rheumatology (ACR) for the classification of systemic lupus erythematosus. Read More

    Exploratory and regulatory assessments on photosafety of new drug entities.
    Curr Drug Saf 2012 Apr;7(2):140-8
    Department of Pharmacokinetics and Pharmacodynamics, School of Pharmaceutical Sciences, University of Shizuoka, Suruga-ku, Japan.
    Drug-induced phototoxicity is elicited after exposure of the skin and/or eyes to topically or systemically administered pharmaceutical substances, followed by exposure to sunlight. This undesirable side effect is one of the impediments in drug discovery and development, and substantial efforts have been made to avoid drug-induced phototoxic reactions. To evaluate the phototoxic potential of compounds, effective methodologies have been developed over the past few years, and screening strategies have also been proposed for predicting in vivo phototoxic reactions. Read More

    Hydroxyurea-induced dermatomyositis: true amyopathic dermatomyositis or dermatomyositis-like eruption?
    Int J Dermatol 2012 May;51(5):535-41
    Department of Dermatology, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
    Background:   Hydroxyurea-induced dermatomyositis is a rare adverse reaction of long-term hydroxyurea therapy. It has been reported under different names; however, the exact classification and nomenclature of this eruption have been the subject of much debate, and a more precise term is still awaiting. Herein, we review the different aspects of this reaction and suggest a new term that might help to minimize the confusion about its nomenclature. Read More

    [Photoallergic drug reactions].
    Acta Med Croatica 2011 ;65(2):107-10
    University Department of Dermatology and Venereology, Zagreb University Hospital Center, Zagreb, Croatia.
    Drug-induced hypersensitivity reactions include phototoxic and photoallergic reactions. Photoallergic reactions, which develop as cell-mediated immune responses to a light-activated compound, are described in this review article. The main topics include photobiology, list of common drugs inducing photoallergic reactions, immune response, clinical features, diagnostic and therapeutic approach. Read More

    Late-onset systemic lupus erythematosus: epidemiology, diagnosis and treatment.
    Drugs Aging 2012 Mar;29(3):181-9
    Department of Internal Medicine, French Reference Center for Systemic Lupus Erythematosus, Groupe Hospitalier Pitié-Salpêtrière, Paris, France.
    Systemic lupus erythematosus (SLE) is usually described as a disease that most often strikes reproductive-age women. However, the onset of SLE beyond the age of 50 years is reported to occur in 3-18% of patients. This later age at onset has a strong modifying effect on the clinical presentation, disease course, response to treatment and prognosis of SLE. Read More

    Granuloma annulare photoinduced by paroxetine.
    Photodermatol Photoimmunol Photomed 2012 Feb;28(1):47-9
    Department of Dermatology, Complejo Hospitalario Universitario, Faculty of Medicine, Santiago de Compostela, A Coruña, Spain.
    Granuloma annulare (GA) is a benign granulomatous skin disease with several clinical manifestations and characteristic histological findings. GA located in photoexposed areas is a rare finding and its association to a drug-induced systemic photosensitivity is even less common. To the best of our knowledge, only one case of systemic drug photosensitivity manifesting as a GA has been reported. Read More

    Photoinduced dermatitis and oral lichenoid reaction in a chronic myeloid leukemia patient treated with imatinib mesylate.
    Photodermatol Photoimmunol Photomed 2012 Feb;28(1):2-5
    Institute of Dermatology, University of Pavia and Foundation IRCCS Policlinico S. Matteo, Pavia, Italy.
    Background: Imatinib mesylate (IM) is a phenylaminopyrimidine that represents the first-line treatment for chronic myeloid leukemia (CML), Philadelphia chromosome-positive. It acts as a potent and selective inhibitor of the bcr-abl fusion protein by a competitive inhibition at the adenosine triphosphate-binding site of the enzyme, which leads to the inhibition of tyrosine phosphorylation of the proteins involved in bcr-abl signal transduction. IM is generally well tolerated and usually provokes only mild side effects consisting of nausea, myalgia, edema and muscle cramps. Read More

    Dysfunction of melanocytes in photoleukomelanoderma following photosensitivity caused by hydrochlorothiazide.
    Photodermatol Photoimmunol Photomed 2011 Dec;27(6):328-30
    Division of Dermatology, Department of Internal Related, Kobe University Graduate School of Medicine, Kobe, Japan.
    We report a 68-year-old Japanese man who developed photoleukomelanoderma following prolonged photosensitivity caused by hydrochlorothiazide. He showed complete recovery from the leukomelanoderma with the discontinuation of the responsive drug and with topical application of tacrolimus hydrate and corticosteroid. Histological and immunohistochemical examination revealed that there were no melanin-positive cells in the hypopigmented area, despite the presence of melanocytes. Read More

    Drug-induced photosensitivity: culprit drugs, management and prevention.
    Drug Saf 2011 Oct;34(10):821-37
    Division of Dermatology, University of Toronto, ON, Canada.
    Photo-induced drug eruptions are cutaneous adverse events due to exposure to a drug and either ultraviolet or visible radiation. Based on their pathogenesis, they can be classified as phototoxic or photoallergic drug eruptions, although in many cases it is not possible to determine whether a particular eruption is due to a phototoxic or photoallergic mechanism. In this review, the diagnosis, prevention and management of drug-induced photosensitivity are discussed. Read More

    Acute and twenty-eight days repeated oral dose toxicity study of besifloxacin in Wistar albino rats.
    Environ Toxicol Pharmacol 2011 Jul 4;32(1):82-101. Epub 2011 Apr 4.
    Bioequivalence Study Centre, Department of Pharmaceutical Technology, Jadavpur University, Kolkata 700032, India.
    The purpose of this study was to investigate the potential acute and 28-day repeated oral toxicities of besifloxacin (BAF) in Wistar albino rats. In oral acute and repeated dose study, BAF was administered to both sex of rats, at dose levels of 0, 300, 600, 900 mg/kg/day and 0, 100, 200, 500 mg/kg/day, respectively. In the acute study, total white blood cell (WBC) (male, 43. Read More

    Cutaneous side effects of antiosteoporosis treatments.
    Ther Adv Musculoskelet Dis 2011 Feb;3(1):31-41
    Department of Internal Medicine, Gent University Hospital, B-9000 Gent, Belgium.
    Cutaneous adverse reactions are reported for many therapeutic agents and, in general, are observed in between 0% and 8% of treated patients depending on the drug. Antiosteoporotic agents are considered to be safe in terms of cutaneous effects, however there have been a number of case reports of cutaneous adverse reactions which warrant consideration. This was the subject of a working group meeting of the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis in April 2009, which focused on the impact of cutaneous adverse reactions and drug-induced hypersensitivity in the management of postmenopausal osteoporosis. Read More

    [Results of skin tests to assess drug-induced allergy].
    Ann Dermatol Venereol 2010 Nov 14;137(11):688-94. Epub 2010 Oct 14.
    Hôpital Fournier, Nancy, France.
    Background: Skin tests are often used to explore adverse drug reactions. The sensitivity of skin tests appears to vary according to the drugs tested and the type of adverse reaction in question. There is no clear strategy to explore drug adverse reactions. Read More

    Severe phototoxicity associated with long-term voriconazole treatment.
    J Dtsch Dermatol Ges 2011 Apr 3;9(4):274-6. Epub 2010 Nov 3.
    Department of Pediatric Dermatology, Catholic Children's Hospital Wilhelmstift, Hamburg, Germany.
    Voriconazole is a second-generation triazole antifungal approved for the treatment of invasive fungal infections, particularly with Aspergillus, Candida, Fusarium, and Scedosporium spp. Frequently reported adverse effects of voriconazole include visual disturbance (21 %), elevated liver enzymes (15.6 %) and rashes (7 %), which are largely attributable to drug-induced photosensitivity. Read More

    Utility of quantitative whole-body autoradiography (QWBA) and imaging mass spectrometry (IMS) by matrix-assisted laser desorption/ionization (MALDI) in the assessment of ocular distribution of drugs.
    J Pharmacol Toxicol Methods 2011 Mar-Apr;63(2):205-8. Epub 2010 Oct 29.
    Research and Development, Pharmaceutical Candidate Optimization, Discovery Analytical Sciences, Bristol-Myers Squibb Company, USA.
    Introduction: Assessment of drug candidate properties and potential liabilities can greatly benefit from issue driven studies that are designed to address specific toxicological effects such as ocular phototoxicity. If a compound absorbs light in the wavelength range of 290-700 nm (UV-A, UV-B, and visible light) and generates a positive response in a standard in vitro neutral red uptake phototoxicity assay in Balb/c 3T3 mouse fibroblasts, a single-dose in vivo study may be conducted to assess the potential for drug-induced phototoxicity in the eyes and skin of pigmented Long-Evans rats. Critical to ocular phototoxicity assessment is the hypothesis that the drug or drug-related material must be present in the affected substructures such as the uveal tract, retina, lens, or cornea. Read More

    Subacute cutaneous lupus erythematosus exacerbated or induced by chemotherapy.
    Arch Dermatol 2010 Oct;146(10):1113-6
    Division of Dermatology, Department of Medicine, University of Louisville School of Medicine, Louisville, Kentucky, USA.
    Background: Subacute cutaneous lupus erythematosus (SCLE), characterized by nonscarring, photodistributed, annular or papulosquamous plaques, is occasionally induced by medication. It has been strongly associated with antihypertensive medications and terbinafine hydrochloride.

    Observation: We describe 3 women with breast cancer who developed SCLE-like eruptions after being administered doxorubicin hydrochloride and cyclophosphamide. Read More

    Facial hyperpigmentation caused by diltiazem hydrochloride.
    Cutis 2010 Aug;86(2):82-4
    Department of Dermatology, St. Luke's-Roosevelt Hospital Center, New York, New York 10025, USA.
    Diltiazem hydrochloride, a member of the calcium channel blocker family of antihypertensive medications, has been found to produce many cutaneous reactions, such as photodistributed hyperpigmentation. We report a 53-year-old black woman who presented with facial darkening that began 6 months after starting diltiazem. Areas were not responsive to topical bleaching creams. Read More

    Diltiazem-associated photodistributed hyperpigmentation: report of two Japanese cases and published work review.
    J Dermatol 2010 Sep;37(9):807-11
    Department of Dermatology, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan.
    Scherschum et al. proposed diltiazem-associated photodistributed hyperpigmentation as a novel type of drug-induced photosensitive lichenoid eruption. The characteristic clinical features were slate-gray reticulated hyperpigmentation on sun-exposed areas, while lichenoid dermatitis with prominent pigmentary incontinence was noted histologically. Read More

    Drug-induced subacute cutaneous lupus erythematosus.
    Lupus 2010 Aug;19(9):1107-11
    Division of Dermatology, Department of Medicine, University of Louisville School of Medicine, Louisville, KY, USA.
    Subacute cutaneous lupus erythematosus (SCLE) is a subset of cutaneous lupus erythematosus with unique immunologic and clinical features. The first description dates back to 1985 when a series of five patients were found to have hydrochlorothiazide-induced SCLE. Since that time, at least 40 other drugs have been implicated in the induction of SCLE. Read More

    Diagnosis and pharmacological treatment of chronic actinic dermatitis in the elderly: an update.
    Drugs Aging 2010 Jun;27(6):451-6
    Department of Dermatology, Gloucester Royal Hospital, Gloucester, UK.
    Chronic actinic dermatitis (CAD) describes a condition resulting from abnormal photosensitivity; the dermatitis is clinically similar to contact allergic dermatitis. Sun-exposed skin is more commonly affected but the condition can extend to and encompass unexposed skin. CAD is relatively rare but becomes more prevalent in the elderly population. Read More

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