82,685 results match your criteria Drug-Induced Photosensitivity


Interstitial Lung Disease Onset and Its Risk Factors in Japanese Patients with ALK-positive NSCLC Following Treatment with Crizotinib.

J Thorac Oncol 2018 Dec 3. Epub 2018 Dec 3.

Tokyo Medical University Hospital, 6-7-1 Nishishinjuku, Shinjuku-ku, Tokyo 160-0023, Japan.

Introduction: The study objective was to determine the incidence and characteristics of drug-induced interstitial lung disease (ILD) associated with an orally available small-molecule tyrosine kinase inhibitor, crizotinib in the real-world clinical setting.

Methods: Post-marketing surveillance was performed in Japan to obtain information on the safety and efficacy of crizotinib. Target patients included all patients with anaplastic lymphoma kinase-positive non-small cell lung cancer (NSCLC) who received crizotinib, during the enrollment period between May 2012 and December 2014. Read More

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December 2018
5 Reads

Opposing Effects of PPARα Agonism and Antagonism on Refractive Development and Form Deprivation Myopia in Guinea Pigs.

Invest Ophthalmol Vis Sci 2018 Dec;59(15):5803-5815

School of Ophthalmology and Optometry and Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China.

Purpose: To determine if drug-induced peroxisome proliferator-activated receptor α (PPARα) signal pathway modulation affects refractive development and myopia in guinea pigs.

Methods: Pigmented guinea pigs were randomly divided into normal vision (unoccluded) and form deprivation myopia (FDM) groups. Each group received daily peribulbar injections of either a vehicle or (1) PPARα agonist, GW7647, clofibrate, or bezafibrate or (2) PPARα antagonist, GW6471, for 4 weeks. Read More

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December 2018

Loss of ARHGEF1 causes a human primary antibody deficiency.

J Clin Invest 2018 Dec 6. Epub 2018 Dec 6.

ARHGEF1 is a RhoA-specific guanine nucleotide exchange factor expressed in hematopoietic cells. We used whole-exome sequencing to identify compound heterozygous mutations in ARHGEF1, resulting in the loss of ARHGEF1 protein expression in two primary-antibody-deficient siblings presenting with recurrent severe respiratory tract infections and bronchiectasis. Both ARHGEF1-deficient patients showed an abnormal B cell immunophenotype, with a deficiency in marginal-zone and memory B cells and an increased frequency of transitional B cells. Read More

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December 2018

Combined effect of GABA and GLP-1 receptor agonist on cytokine-induced apoptosis in pancreatic β-cell lines and isolated human islets.

J Diabetes 2018 Dec 5. Epub 2018 Dec 5.

Division of Endocrinology and Metabolism, Keenan Research Centre for Biomedical Science, St. Michael's Hospital, Toronto, Ontario, Canada.

Background: Gamma-aminobutyric acid (GABA) or glucagon-like peptide-1 (GLP-1) treatment can preserve pancreatic β-cell mass and prevent diabetes. Recently, we reported that the combination of GABA and sitagliptin (a dipeptidyl peptidase-4 inhibitor that increases endogenous GLP-1) was more effective than either agent alone in reducing drug-induced β-cell damage and promoting β-cell regeneration in mice. However, in human islets, it remains unclear whether GABA and GLP-1 exert similar effects. Read More

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December 2018

Co-existence of Rolandic and 3 Hz Spike-Wave Discharges on EEG in Children with Epilepsy.

Can J Neurol Sci 2018 Dec 3:1-7. Epub 2018 Dec 3.

1Department of Pediatrics, Division of Neurology,BC Children's Hospital,Vancouver, British Columbia,Canada.

Objective: Benign epilepsy of childhood with central temporal spikes (BECTS) and absence epilepsy are common epilepsy syndromes in children with similar age of onset and favorable prognosis. However, the co-existence of the electrocardiogram (EEG) findings of rolandic spike and 3 Hz generalized spike-wave (GSW) discharges is extremely rare, with few cases reported in the literature. Our objective was to characterize the EEG findings of these syndromes in children in our center and review the electro-clinical features. Read More

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December 2018

Epiglottis shape as a predictor of obstruction level in patients with sleep apnea.

Sleep Breath 2018 Nov 30. Epub 2018 Nov 30.

Department of Otolaryngology-Head and Neck Surgery, General Hospital Celje, Oblakova ulica 5, 3000, Celje, Slovenia.

Purpose: Despite a broad range of diagnostic methods, identifying the site of obstruction in the upper respiratory tract in patients with obstructive sleep apnea is not always simple and straightforward. With regard to this problem, we present our observations about the specific shape of the epiglottis in patients with obstruction at the level of the tongue base and/or epiglottis.

Methods: One hundred and forty consecutive drug-induced sleep endoscopy (DISE) video recordings of patients with polygraphy-verified obstructive sleep apnea were analyzed by three independent observers. Read More

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November 2018

Mitochondrial dysfunction as a mechanism of drug-induced hepatotoxicity: current understanding and future perspectives.

J Clin Transl Res 2018 28;4(1). Epub 2018 May 28.

Department of Pharmacology, Toxicology & Therapeutics, University of Kansas Medical Center, Kansas City, KS, US.

Mitochondria are critical cellular organelles for energy generation and are now also recognized as playing important roles in cellular signaling. Their central role in energy metabolism, as well as their high abundance in hepatocytes, make them important targets for drug-induced hepatotoxicity. This review summarizes the current mechanistic understanding of the role of mitochondria in drug-induced hepatotoxicity caused by acetaminophen, diclofenac, anti-tuberculosis drugs such as rifampin and isoniazid, anti-epileptic drugs such as valproic acid and constituents of herbal supplements such as pyrrolizidine alkaloids. Read More

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Lamotrigine-induced Systemic Lupus Erythematosus: A Diagnostic Dilemma.

Indian Dermatol Online J 2018 Nov-Dec;9(6):445-447

Department of Pathology, Dayanand Medical College and Hospital, Ludhiana, Punjab, India.

Many drugs are known to cause systemic lupus erythematosus (SLE), however there are no well defined criteria for drug induced lupus erythematosus (DILE). We present a rare case of lamotrigine induced lupus presenting as acute syndrome of apoptotic pan epidermolysis (ASAP). Read More

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December 2018

[Analysis of Time-to-onset and Onset-pattern of Interstitial Lung Disease after the Administration of Monoclonal Antibody Agents].

Yakugaku Zasshi 2018 ;138(12):1587-1594

Faculty of Pharmaceutical Sciences, Himeji Dokkyo University.

The aim of this study has been to investigate the time-to-onset and onset-pattern of drug-induced interstitial lung disease (DILD) after the administration of monoclonal antibodies through the use of the spontaneous adverse reaction reporting system of the Japanese Adverse Drug Event Report database. DILD datasets for adalimumab, bevacizumab, cetuximab, denosumab, golimumab, infliximab, nivolumab, panitumumab, pembrolizumab, tocilizumab, and trastuzumab were used to calculate the median time-to-onset of DILD, as well as the Weibull distribution parameters. The median time-to-onset of DILD for pembrolizumab and infliximab was within 1 month. Read More

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January 2018

Drug-associated thrombocytopenia.

Hematology Am Soc Hematol Educ Program 2018 Nov;2018(1):576-583

Transfusion Medicine, Medical Faculty of Tubingen, University of Tubingen, Tubingen, Germany.

Many drugs have been implicated in drug-induced immune thrombocytopenia (DITP). Patients with DITP develop a drop in platelet count 5 to 10 days after drug administration with an increased risk of hemorrhage. The diagnosis of DITP is often challenging, because most hospitalized patients are taking multiple medications and have comorbidities that can also cause thrombocytopenia. Read More

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November 2018
2 Reads

Surgical ablation of lingual tonsils in the treatment of obstructive sleep apnea.

Eur Ann Otorhinolaryngol Head Neck Dis 2018 Nov 29. Epub 2018 Nov 29.

Dept Otolaryngology-Head & Neck Surgery, Foch Hospital, 40, rue Worth, 92150 Suresnes, France. Electronic address:

Objectives/hypothesis: The retrolingual space is one of the potential sites of obstruction identified in patients with obstructive sleep apnea syndrome (OSAS). Hypertrophied lingual tonsils (LT) can obstruct the airway at this level. The goal of this study was to measure the tolerance and efficacy of lingual tonsillectomy in patients with OSAS. Read More

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November 2018
1 Read

Drug-Induced Fixed Urticaria as a Presentation of NSAID Intolerance.

J Allergy Clin Immunol Pract 2018 Nov 29. Epub 2018 Nov 29.

Department of Allergy, Hospital Universitario de La Princesa, Instituto de Investigación Sanitaria Princesa (IP), Madrid, Spain; RETIC ARADYAL RD16/0006/0015, Instituto de Salud Carlos III, Madrid, Spain.

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November 2018

[Tubulointerstitiel nephritis and Crohn's disease, nephrotoxicity or extraintestinal manifestation of Crohn's disease? About a case].

Nephrol Ther 2018 Nov 29. Epub 2018 Nov 29.

Laboratoire d'anatomie pathologique, CHRU de Nancy, 5, rue de Morvan, 54500 Vandœuvre-lès-Nancy, France.

Extraintestinal manifestations in inflammatory bowel disease involve most frequently the joints, the skin, the eyes, the liver and the biliary tract. Renal involvement is rare, and manifested as nephrolithiasis, tubulointerstitial nephritis, glomerulonephritis and amyloidosis. In patients with inflammatory bowel disease, renal disease is most frequently due to treatment nephrotoxicity and rarely as a guenine extraintestinal manifestation of inflammatory bowel disease. Read More

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November 2018

Prediction of Drug-Related Risks Using Clinical Context Information in Longitudinal Claims Data.

Value Health 2018 Dec 30;21(12):1390-1398. Epub 2018 Jun 30.

Department of Clinical Pharmacology and Pharmacoepidemiology, University of Heidelberg, Heidelberg, Germany. Electronic address:

Objectives: To develop and internally validate prediction models for medication-related risks arising from overuse, misuse, and underuse that utilize clinical context information and are suitable for routine risk assessment in claims data (i.e., medication-based models predicting the risk for hospital admission apparent in routine claims data or MEDI-RADAR). Read More

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December 2018

Reprint of "The interaction between environmental triggers and epigenetics in autoimmunity".

Authors:
Bruce Richardson

Clin Immunol 2018 Nov 30. Epub 2018 Nov 30.

Department of Internal Medicine, Division of Rheumatology, University of Michigan, SRB 3007, 109 Zina Pitcher Pl., Ann Arbor, MI 48109-2200, United States. Electronic address:

Systemic lupus erythematosus flares when genetically predisposed people encounter environmental agents that cause oxidative stress, such as infections and sunlight. How these modify the immune system to initiate flares is unclear. Drug induced lupus models demonstrate that CD4+ T cells epigenetically altered with DNA methylation inhibitors cause lupus in animal models, and similar T cells are found in patients with active lupus. Read More

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November 2018

Voriconazole-Induced Periostitis After Allogeneic Stem Cell Transplantation.

Clin Nucl Med 2018 Dec 3. Epub 2018 Dec 3.

From the Departments of Nuclear Medicine and Molecular Imaging, and.

A 34-year-old man with history of Hodgkin lymphoma presented 7 months after allogeneic stem cell transplantation with an unexplained severe musculoskeletal pain syndrome. A Tc-MDP bone SPECTCT showed multiple foci with moderate to intense bone uptake across the axial and appendicular skeleton consistent with periostitis. The patient had been on voriconazole daily for 4 months to treat an Aspergillus pneumonia, and in the absence of other causes, a drug-induced periostitis was suspected. Read More

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December 2018
3 Reads

Incidental 18F-NaF Uptake in Drug-Induced Gynecomastia.

Clin Nucl Med 2018 Dec 3. Epub 2018 Dec 3.

Gynecomastia is not uncommon in men older than 50 years of age and is characterized by glandular proliferation of breast tissue. Non-physiologic gynecomastia is mostly caused by a variety of external medical interventions. Medications that belong to classes of antiandrogens, antipsychotics, or antibiotics alter the levels of estrogen and testosterone and are commonly implicated in patients with gynecomastia. Read More

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December 2018
1 Read

Drug-induced liver injury with skin reactions: Drugs and host risk factors, clinical phenotypes and prognosis.

Liver Int 2018 Dec 4. Epub 2018 Dec 4.

Department of Dermatology, St. John's Medical College Hospital, Bangalore, India.

While dermatologic manifestations of adverse drug reactions are frequent, drug-induced liver injury is rare. Numerous drugs are implicated in either Drug-Induced Liver Injury or Drug-Induced Skin Injury. However, concomitant Drug-Induced Liver Injury and Drug-Induced Skin Injury are uncommon, not well characterized and appear to be caused by a limited number of drugs. Read More

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December 2018
2 Reads

Revised Antituberculosis Drug Doses and Hepatotoxicity in HIV Negative Children.

Indian J Pediatr 2018 Dec 4. Epub 2018 Dec 4.

Department of Pediatrics, St John's Medical College Hospital, Bengaluru, Karnataka, India.

Objectives: To compare the incidence of anti tuberculosis drug-induced hepatotoxicity (ATDH) with those on old vs. revised WHO doses in human immunodeficiency virus (HIV) negative children. The secondary objective was to determine the overall incidence of hepatitis in children on Anti tubercular treatment (ATT) and isoniazid prophylactic therapy (IPT). Read More

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December 2018
2 Reads

A Comparative Study on Efficacy and Safety of Propofol versus Dexmedetomidine in Sleep Apnea Patients undergoing Drug-Induced Sleep Endoscopy: .

Biomed Res Int 2018 1;2018:8696510. Epub 2018 Nov 1.

Department of Anesthesiology, The First Affiliated Hospital of Soochow University, Soochow University, Suzhou 215006, Jiangsu, China.

The aim of this study is to compare the efficacy and safety of propofol with dexmedetomidine in patients with obstructive sleep apnea hypopnea syndrome (SAHS) undergoing drug-induced sleep endoscopy (DISE). The 88 patients diagnosed with SAHS in the Affiliated Hospital of Xuzhou Medical University were randomly allocated into 2 groups (n = 44). Patients in the group dexmedetomidine (group D) received continuous intravenous infusion of dexmedetomidine 1 g/kg over 15 minutes before the endoscopy, and propofol 2 mg/kg was intravenously administrated in the group propofol (group P). Read More

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November 2018

Embracing the Dark Side: Computational Approaches to Unveil the Functionality of Genes Lacking Biological Annotation in Drug-Induced Liver Injury.

Front Genet 2018 20;9:527. Epub 2018 Nov 20.

Department of Toxicogenomics, GROW School for Oncology and Developmental Biology, Maastricht University, Maastricht, Netherlands.

In toxicogenomics, functional annotation is an important step to gain additional insights into genes with aberrant expression that drive pathophysiological mechanisms. Nevertheless, there exists a gap on annotation of these genes which often hampers the interpretation of results and limits their applicability in translational medicine. In this study, we evaluated the coverage of functional annotations of differentially expressed genes (DEGs) induced by 10 selected compounds from the TG-GATEs database identified as high- or no-risk in causing drug-induced liver injury (most-DILI or no-DILI, respectively) using human data. Read More

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November 2018

Inversion and computational maturation of drug response using human stem cell derived cardiomyocytes in microphysiological systems.

Sci Rep 2018 Dec 4;8(1):17626. Epub 2018 Dec 4.

Departments of Bioengineering, Material Science and Engineering, University of California, Berkeley, California, USA.

While cardiomyocytes differentiated from human induced pluripotent stems cells (hiPSCs) hold great promise for drug screening, the electrophysiological properties of these cells can be variable and immature, producing results that are significantly different from their human adult counterparts. Here, we describe a computational framework to address this limitation, and show how in silico methods, applied to measurements on immature cardiomyocytes, can be used to both identify drug action and to predict its effect in mature cells. Our synthetic and experimental results indicate that optically obtained waveforms of voltage and calcium from microphysiological systems can be inverted into information on drug ion channel blockage, and then, through assuming functional invariance of proteins during maturation, this data can be used to predict drug induced changes in mature ventricular cells. Read More

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December 2018

GPIHBP1 autoantibody syndrome during interferon β1a treatment.

J Clin Lipidol 2018 Oct 24. Epub 2018 Oct 24.

Departments of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA, USA. Electronic address:

Background: Autoantibodies against glycosylphosphatidylinositol-anchored high-density lipoprotein-binding protein 1 (GPIHBP1) cause chylomicronemia by blocking the ability of GPIHBP1 to bind lipoprotein lipase (LPL) and transport the enzyme to its site of action in the capillary lumen.

Objective: A patient with multiple sclerosis developed chylomicronemia during interferon (IFN) β1a therapy. The chylomicronemia resolved when the IFN β1a therapy was discontinued. Read More

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October 2018

Using Evidence-Based Dentistry in the Clinical Management of Combined Periodontal Conditions.

J Evid Based Dent Pract 2018 Dec 13;18(4):290-297. Epub 2018 Feb 13.

Department of Periodontology, Tufts University School of Dental Medicine, Boston, MA, USA.

Objective: This report proposes a framework to integrate evidence-based dentistry (EBD) in a systematic approach in the clinical management of a patient diagnosed with drug-induced gingival hyperplasia combined with generalized aggressive periodontitis.This report illustrates the case of a 37-year-old female who presented to the Department of Periodontology at Tufts University School of Dental Medicine with enlarged, tender, bleeding gums, and loose teeth combined with a history of uncontrolled hypertension treated with calcium channel blockers.

Methods: Incorporating the EBD process, a new 5-step framework is proposed: ask the clinical question, acquire and appraise the evidence, apply it in the clinical setting, and assess the subjective and objective outcomes. Read More

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December 2018
2 Reads

Drug Hypersensitivity Reactions Documented in Electronic Health Records within a Large Health System.

J Allergy Clin Immunol Pract 2018 Dec 1. Epub 2018 Dec 1.

Division of General Internal Medicine and Primary Care, Brigham and Women's Hospital, Boston, MA; Harvard Medical School, Boston, MA. Electronic address:

Background: Hypersensitivity reactions (HSRs) are immunologic responses to drugs. Identification of HSRs documented in the electronic health record (EHR) is important for patient safety.

Objective: To examine HSR epidemiology using longitudinal EHR data from a large United States healthcare system. Read More

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December 2018
2 Reads

Drug-induced linear IgA bullous dermatosis: a French retrospective pharmacovigilance study of 69 cases.

Br J Clin Pharmacol 2018 Dec 4. Epub 2018 Dec 4.

EA 7379 EpiDermE, Université Paris Est Créteil Val de Marne UPEC, Créteil, France.

Aims: Linear immunoglobin A (IgA) bullous dermatosis (LABD) is a rare autoimmune dermatosis considered spontaneous or drug-induced (DILAD). We assessed all DILAD cases, determined the imputability score of drugs, highlighted suspected drugs.

Methods: Data for patients with DILAD were collected retrospectively from the French Pharmacovigilance network (from 1985 to 2017) and from physicians involved in the Bullous Diseases French Study Group and the French Investigators for Skin Adverse Reactions to Drugs. Read More

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December 2018
1 Read

Mirtazapine-induced hyperpigmentation with type II histopathologic findings.

JAAD Case Rep 2018 Nov 14;4(10):1077-1079. Epub 2018 Nov 14.

Ronald O. Perelman Department of Dermatology, NYU Langone Health, New York, New York.

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November 2018

An method for nephrotoxicity evaluation using HK-2 human kidney epithelial cells combined with biomarkers of nephrotoxicity.

Toxicol Res (Camb) 2018 Nov 13;7(6):1205-1213. Epub 2018 Aug 13.

Chinese Academy of Medical Sciences & Peking Union Medical College , No. 9 , Dongdan Santiao , Dongcheng District , Beijing 100730 , China . Email:

The kidney is one of the major target organs for drug-induced toxicity. During drug development, the traditional markers of nephrotoxicity indicate only severe and late damage, which leads to high costs. The new biomarkers are needed for a more sensitive and reliable evaluation of nephrotoxicity, especially for the regulatory accepted and validated model. Read More

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November 2018
1 Read

FMT for drug-induced colitis.

Authors:
Hugh Thomas

Nat Rev Gastroenterol Hepatol 2018 Dec 3. Epub 2018 Dec 3.

Nature Reviews Gastroenterology & Hepatology, .

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December 2018
6 Reads

Successful treatment of drug-induced esophageal ulcer in a patient with chronic heart failure: A case report.

Medicine (Baltimore) 2018 Nov;97(48):e13380

Department of Gastroenterology and Hepatology.

Rationale: Although esophageal compression due to cardiomegaly may be a risk factor of drug-induced esophageal injuries (DIEIs), the causal relationship between the two conditions has not been fully demonstrated.

Patient Concerns: We present a case of a drug-induced esophageal ulcer caused by left atrial enlargement in a 44-year-old woman with end-stage hypertrophic cardiomyopathy. Upper gastrointestinal endoscopy showed a deep, circumferential ulcer in the middle thoracic esophagus. Read More

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November 2018
3 Reads

Tox_(R)CNN: Deep learning-based nuclei profiling tool for drug toxicity screening.

PLoS Comput Biol 2018 Nov 30;14(11):e1006238. Epub 2018 Nov 30.

Cellomics Unit, Cell & Developmental Biology Area, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain.

Toxicity is an important factor in failed drug development, and its efficient identification and prediction is a major challenge in drug discovery. We have explored the potential of microscopy images of fluorescently labeled nuclei for the prediction of toxicity based on nucleus pattern recognition. Deep learning algorithms obtain abstract representations of images through an automated process, allowing them to efficiently classify complex patterns, and have become the state-of-the art in machine learning for computer vision. Read More

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November 2018
1 Read

Generation of mature kupffer cells from human induced pluripotent stem cells.

Biomaterials 2018 Nov 16;192:377-391. Epub 2018 Nov 16.

Institute of Bioengineering and Nanotechnology, #04-01, 31 Biopolis Way, The Nanos, Singapore 138669, Singapore; Department of Physiology, Yong Loo Lin School of Medicine, National University Health System, MD9-03-03, 2 Medical Drive, Singapore 117597, Singapore; NUS Graduate School for Integrative Sciences and Engineering, Centre for Life Sciences, #05-01, 28 Medical Drive, Singapore 117576, Singapore; Mechanobiology Institute, T-Labs, #05-01, 5A Engineering Drive 1, Singapore 117411, Singapore; Singapore-MIT Alliance for Research and Technology, 3 Science Drive 2, S16-05-08, Singapore 117543, Singapore; Department of Biological Engineering, Massachusetts Institute of Technology, 77 Massachusetts Ave., Cambridge, MA 02139, USA; Gastroenterology Department, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China. Electronic address:

Liver macrophages, Kupffer cells (KCs), play a critical role in drug-induced liver injury (DILI) and liver diseases including cholestasis, liver fibrosis and viral hepatitis. Application of KCs in in vitro models of DILI and liver diseases is hindered due to limited source of human KCs. In vivo, KCs originate from MYB-independent macrophage progenitors, which differentiate into liver-specific macrophages in response to hepatic cues in the liver. Read More

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November 2018

A Performance Evaluation of Liver and Skeletal Muscle -Specific miRNAs in Rat Plasma to Detect Drug Induced Injury.

Toxicol Sci 2018 Nov 28. Epub 2018 Nov 28.

Safety Assessment and Laboratory Animal Resources, Merck & Co., Inc., West Point, Pennsylvania, USA.

Liver and skeletal muscle specific microRNAs (miRNAs) are currently being evaluated as novel plasma biomarkers that may out-perform or add value to the conventional liver injury biomarkers alanine aminotransferase (ALT) and aspartate aminotransferase (AST), and to the skeletal muscle injury biomarkers AST and creatine kinase (CK). A comprehensive evaluation was conducted to assess the relative performance of these miRNAs to detect and distinguish liver from muscle tissue injury. The performance of miR-122 and miR-192 for liver and miR-1, miR-133a, miR-133b, and miR-206 for skeletal muscle was compared to 10 enzymatic or protein biomarkers across 27 compounds causing specific types of tissue injury in rat. Read More

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November 2018
2 Reads

Hypertension induced by serotonin reuptake inhibitors: Analysis of two pharmacovigilance databases.

Fundam Clin Pharmacol 2018 Nov 29. Epub 2018 Nov 29.

Normandie Université, UNICAEN, EA4650, CHU Caen Normandie, Service de pharmacologie, 14000, Caen, France.

Drug-induced hypertension was described with several pharmacological classes, especially with serotonin reuptake inhibitors (SRIs). However, this link has remained controversial: the French summary of product characteristics specify a risk of hypertension only with paroxetine and sertraline. To identify a possible class effect common to all SRIs, our study investigated the reports of hypertension associated with SRIs in two pharmacovigilance databases. Read More

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November 2018
2 Reads

A Rare Case of Levetiracetam and Drug-Induced Idiopathic Aseptic Meningitis in a Pediatric Patient.

Pharmacotherapy 2018 Nov 29. Epub 2018 Nov 29.

Hovnanian Children's Hospital at Hackensack Meridian Health, Hackensack, New Jersey.

Levetiracetam (LEV) is a pyrrolidine derivative antiepileptic medication used for treatment of seizures in pediatric and adult patients. We report a case of probable LEV-induced aseptic meningitis in a 13-year-old female. The patient received LEV for a generalized seizure disorder and presented with symptoms 5 days after medication initiation. Read More

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November 2018

How to fluorescently label the potassium channel: A case in hERG.

Curr Med Chem 2018 Nov 28. Epub 2018 Nov 28.

Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (MOE), School of Pharmacy, Shandong University, Jinan, Shandong 250012. China.

hERG (Human ether-a-go-go-related gene) potassium channel, which plays an essential role in cardiac action potential repolarization, is responsible for inherited and drug-induced long QT syndrome. Recently, the Cryo-EM structure capturing the open conformation of hERG channel was determined, thus pushing the study on hERG channel at 3.8 Å resolution. Read More

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November 2018
2 Reads

Dynamic Contrast-Enhanced Magnetic Resonance Imaging of OATP Dysfunction in Diabetes.

Diabetes 2018 Nov 28. Epub 2018 Nov 28.

Department of Radiology, Michigan State University, East Lansing, MI

Diabetes mellitus is associated with hepatic metabolic dysfunction predisposing patients to drug induced liver injury. Mouse models of Type 2 diabetes (T2D) have dramatically reduced expression of Organic Anion Transporting Polypeptide (OATP) 1A1, a transporter expressed in hepatocytes and in the kidneys. Effects of diabetes on OATP1B2 expression are less studied and less consistent. Read More

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November 2018
1 Read

[Protective effects of Sedum sarmentosum under different soil moisture in CCl₄-induced damage in HepG2 cells].

Zhongguo Zhong Yao Za Zhi 2018 Oct;43(20):4111-4117

Institute of Chinese Medicinal Materials, Nanjing Agricultural University, Nanjing 210095, China.

At present, there were few studies about the effects of cultivation measures on the quality and pharmacological activity of medicinal plants. To explore the hepetoprotective activity of Sedum sarmentosum aqueous extracts after different water treatments, S. sarmentosum were planted under five water treatments for 60 days, namely 15%-20% FC (field capacity, S1), 35%-40% FC (S2), 55%-60% FC (S3), 75%-80% FC(S4), and 95%-100% FC (S5) and CCl₄ drug-induced liver injury model in vitro was used. Read More

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October 2018

[Effect of six components in Polygoni Multiflori Radix on regulation of CYP3A4 mediated by human pregnane X receptor].

Zhongguo Zhong Yao Za Zhi 2018 Oct;43(20):4104-4110

College of Life Science and Bioengineering, Beijing University of Technology, Beijing 100124, China.

This paper aimed to study the six chemical components of Polygoni Multiflori Radix (gallic acid, quercetin, luteolin, kaempferol, resveratrol, apigenin). By the established pregnane X receptor (human pregnant X receptor, PXR) CYP3A4 mediated drug induced rapid screening technique, the effect of chemical components on the cell activity was detected by MTS cell method, and the value of IC₅₀ was calculated. The dual luciferase reporter system was used to co-transfect PXR reporter gene expression vector containing transcriptional regulation and CYP3A4 with HepG2 cells, with 10 μmol·L⁻¹ rifampicin (RIF) as a positive control, and 10 μmol·L⁻¹ of ketoconazole (TKZ) as negative control. Read More

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October 2018
2 Reads

Acute Liver Failure.

Semin Respir Crit Care Med 2018 Oct 28;39(5):513-522. Epub 2018 Nov 28.

Department of Medicine, Emory University School of Medicine, Atlanta, Georgia.

Acute liver failure (ALF) is a condition that can rapidly progress to multiorgan failure. This article focuses on the diagnosis and management of ALF. We provide a detailed review of the common etiologies of ALF, including acetaminophen overdose, viral hepatitis, drug-induced liver injury, Wilson's disease, and autoimmune hepatitis. Read More

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October 2018

Early memory consolidation window enables drug induced state-dependent memory.

Neuropharmacology 2018 Nov 25;146:84-94. Epub 2018 Nov 25.

División de Neurociencias, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Circuito Exterior, Ciudad Universitaria, 04510, Mexico City, Mexico.

It is well established that newly acquired information is stabilized over time by processes underlying memory consolidation, these events can be impaired by many drug treatments administered shortly after learning. The consolidation hypothesis has been challenged by a memory integration hypothesis, which suggests that the processes underlying new memories are vulnerable to incorporation of the neurobiological alterations induced by amnesic drugs generating a state-dependent memory. The present experiments investigated the effects of amnesic drugs infused into the insular cortex of male Wistar rats on memory for object recognition training. Read More

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November 2018
1 Read

DRESS/DIHS caused by levofloxacin in a patient with systemic scleroderma, rheumatoid arthritis, and Sjogren syndrome.

Contact Dermatitis 2018 Nov 28. Epub 2018 Nov 28.

Department of Endocrinology, Metabolism and Nephrology, Kochi Medical School, Nankoku, Kochi, Japan.

Drug-induced hypersensitivity syndrome (DIHS) or drug reaction with eosinophilia and systemic symptoms (DRESS) is a rare, severe skin disease with manifestations such as fever, eosinophilia, lymphadenopathy and internal organ damage that typically develops 2 to 6 weeks after drug intake. DRESS/DIHS follows a prolonged course involving frequent flare-ups and relapses over weeks or months after treatment discontinuation. Read More

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November 2018
2 Reads

Continuing war on pain: a personalized approach to the therapy with nonsteroidal anti-inflammatory drugs and opioids.

Per Med 2018 Nov 28. Epub 2018 Nov 28.

St Catherine Specialty Hospital, 10000 Zagreb & 49210 Zabok, Croatia.

Successful pain management requires the delivery of analgesia with minimal risk of adverse drug reactions. Nonsteroidal anti-inflammatory drugs and opioids remain the mainstay of treatment for the majority of patients. Unfortunately, almost 50% of all patients experience inadequate pain relief and serious side effects. Read More

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November 2018
1 Read

Kombiglyze (metformin and saxagliptin)-induced hepatotoxicity in a patient with non-alcoholic fatty liver disease.

JGH Open 2018 Oct 1;2(5):242-245. Epub 2018 Oct 1.

Department of Pathology University Malaya Kuala Lumpur Malaysia.

A 33-year-old man was referred with hyperosmotic symptoms of 4 weeks. Clinical examination showed palpable hepatomegaly and no stigmata of liver disease. Findings were random glucose 16. Read More

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October 2018
2 Reads

Differential characteristics in drug-induced autoimmune hepatitis.

JGH Open 2018 Jun 24;2(3):97-104. Epub 2018 May 24.

Gastrohepatology Group Universidad de Antioquia Medellín Colombia.

Background And Aim: Drug-induced autoimmune hepatitis (DIAIH) is an adverse effect associated with several drugs that usually occurs acutely, with variable latency, and it may potentially be mortal. There are a few reports and studies about DIAIH.

Methods: This was an analytical study of a retrospective cohort of patients, discriminated according to idiopathic or drug-induced etiology, followed up for a 7-year period until 31 December 2016. Read More

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June 2018
1 Read

[A case of drug-induced liver injury combined with drug-induced immune thrombocytopenia].

Zhonghua Gan Zang Bing Za Zhi 2018 Sep;26(9):705-706

Department of Hepatology, The First Hospital of Jilin University, Changchun 130021, China.

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September 2018

[Clinical features of drug-induced liver injury rechallenge with polygonum multiflorum].

Zhonghua Gan Zang Bing Za Zhi 2018 Sep;26(9):686-689

Department of Hepatology, Changzhou Third People's Hospital, Changzhou 213001, Jiangsu Province, China.

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September 2018
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