39,174 results match your criteria Drug-Induced Hepatotoxicity

Identification of MRI features associated with injury type, severity, and prognosis in drug-induced liver injury.

Eur Radiol 2022 Aug 18. Epub 2022 Aug 18.

Liver Research Center, Beijing Friendship Hospital, Key Laboratory on Translational Medicine on Cirrhosis, National Clinical Research Center for Digestive Disease, Capital Medical University, Beijing, China.

Objectives: To identify magnetic resonance imaging (MRI) features associated with injury type, severity, and liver transplantation (LT)/liver-related death (LRD) in drug-induced liver injury (DILI).

Methods: The eligible DILI patients (2016 to 2020) who underwent contrast abdominal MRI within 3 months of onset were retrospectively analysed at Beijing Friendship Hospital, Capital Medical University. The MRI features independently associated with severity and prognosis were identified by backwards logistic regression. Read More

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The spike of SARS-CoV-2 promotes metabolic rewiring in hepatocytes.

Commun Biol 2022 Aug 17;5(1):827. Epub 2022 Aug 17.

Liver Disease Lab, CIC bioGUNE, Basque Research and Technology Alliance (BRTA), 48160, Derio, Bizkaia, Spain.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes a multi-organ damage that includes hepatic dysfunction, which has been observed in over 50% of COVID-19 patients. Liver injury in COVID-19 could be attributed to the cytopathic effects, exacerbated immune responses or treatment-associated drug toxicity. Herein we demonstrate that hepatocytes are susceptible to infection in different models: primary hepatocytes derived from humanized angiotensin-converting enzyme-2 mice (hACE2) and primary human hepatocytes. Read More

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The Efficacy of Albumin Dialysis in the Treatment of Severe Cholestatic Drug-Induced Liver Injury.

Crit Care Explor 2022 Aug 11;4(8):e0752. Epub 2022 Aug 11.

Department of Medicine, Emory University School of Medicine, Atlanta, GA.

Drug-induced liver injury (DILI) is a significant cause of acute liver injury and can present as cholestatic injury with or without associated hepatitis. Although most patients with DILI recover with supportive care, some can develop severe refractory cholestasis that impairs recovery of hepatic function, with subsequent progression to acute or chronic liver failure. Current pharmacotherapy and extracorporeal therapies such as hemodialysis have limited benefit. Read More

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Discovery of bakuchiol as an AIM2 inflammasome activator and cause of hepatotoxicity.

J Ethnopharmacol 2022 Aug 13:115593. Epub 2022 Aug 13.

Senior Department of Hepatology, the Fifth Medical Center of PLA General Hospital, China; Military Institute of Chinese Materia, the Fifth Medical Center of PLA General Hospital, China. Electronic address:

Ethnopharmacological Relevance: Psoralea corylifolia (P. corylifolia Linn.) is a traditional Chinese medicinal plant that exhibits significant aphrodisiac, diuretic, and anti-rheumatic effects. Read More

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Mitochondria-Targeted Ratiometric Chemdosimeter to Detect Hypochlorite Acid for Monitoring the Drug-Damaged Liver and Kidney.

Anal Chem 2022 Aug 16. Epub 2022 Aug 16.

School of Engineering, China Pharmaceutical University, Nanjing 211198, China.

Liver and kidney injury caused by drug toxicity is a serious threat to human health. Acetaminophenol (APAP), as a common antipyretic and analgesic drug, inevitably causes injury. When it is overused, hypochlorous acid (HClO) is excessively generated due to metabolic abnormalities, resulting in the accumulation of HClO in the mitochondria of liver and kidney tissues and causing damage. Read More

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Novel [email protected]: In vitro characterization and in vivo evaluation of protection against drug-induced hepatotoxicity.

Chem Biol Interact 2022 Aug 12:110095. Epub 2022 Aug 12.

College of Chemical Engineering, Qingdao University of Science and Technology, Qingdao, China; Qingdao Women and Children's Hospital, Qingdao, 266034, China. Electronic address:

A novel nanoformulation with the small molecule phytochemical dipotassium glycyrrhizinate as a nanomaterial was developed for the oral delivery of luteolin (Lut), a widely used phytochemical, but it suffered from poor water solubility and low oral bioavailability. This novel nanoformulation, named [email protected], can be fabricated with a simple process. [email protected] can instantly dissolve into aqueous mediums and formulate through self-assembly a clear phytomicelle solution with a Lut encapsulation efficiency of 99. Read More

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Role of nuclear pregnane X receptor in Cu-induced lipid metabolism and xenobiotic responses in largemouth bass ().

Front Endocrinol (Lausanne) 2022 28;13:950985. Epub 2022 Jul 28.

Key Laboratory of Tropical and Subtropical Fishery Resource Application and Cultivation, Pearl River Fisheries Research Institute, Chinese Academy of Fishery Sciences, Guangzhou, China.

The pregnane X receptor (PXR) is a master xenobiotic-sensing receptor in response to toxic byproducts, as well as a key regulator in intermediary lipid metabolism. Therefore, the present study was conducted to investigate the potential role of PXR in mediating the lipid dysregulation and xenobiotic responses under Cu-induced stress in largemouth bass (). Four groups of largemouth bass (52. Read More

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Drug-induced severe liver injury due to : a case report with causality assessment from possible to probable.

J Biomed Res 2022 May;36(3):215-220

Department of Infectious Diseases and Hepatic Diseases, the First People's Hospital of Yunnan Province, the Affiliated Hospital of Kunming University of Science and Technology, Kunming, Yunnan 650032, China.

gum, the dry exudate of and other members of the same genus, is used as a thickener and emulsifier in foods. It is generally considered safe as a food or drug, and its adverse reactions, such as -induced liver injury, have never been reported. A 46-year-old woman was admitted to hospital with fatigue, nausea, abdominal distension, jaundice and a >16-fold increase in transaminase and bilirubin level. Read More

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In vitro/in silico prediction of drug induced steatosis in relation to oral doses and blood concentrations by the Nile Red Assay.

Toxicol Lett 2022 Aug 10. Epub 2022 Aug 10.

Leibniz Research Centre for Working Environment and Human Factors at the Technical University of Dortmund (IfADo), Ardeystrasse 67, 44139, Dortmund, Germany. Electronic address:

The accumulation of lipid droplets in hepatocytes is a key feature of drug-induced liver injury (DILI) and can be induced by a subset of hepatotoxic compounds. In the present study, we optimized and evaluated an in vitro technique based on the fluorescent dye Nile Red, further named Nile Red assay to quantify lipid droplets induced by the exposure to chemicals. The Nile Red assay and a cytotoxicity test (CTB assay) were then performed on cells exposed concentration-dependently to 60 different compounds. Read More

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Identification of intrinsic hepatotoxic compounds in Polygonum multiflorum Thunb. using machine-learning methods.

J Ethnopharmacol 2022 Aug 10;298:115620. Epub 2022 Aug 10.

National Institutes for Food and Drug Control, Institute for Control of Chinese Traditional Medicine and Ethnic Medicine, Beijing, 102629, China. Electronic address:

Ethnopharmacological Relevance: Polygonum multiflorum Thunb. (PM) is a herb, extracts of which have been used as Chinese medicine for years. Although it is believed to be beneficial to the liver, heart, and kidneys, it causes idiosyncratic drug-induced liver injury (DILI). Read More

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Differences in clinical characteristics among 726 patients with Chinese herbal medicine- or Western medicine-induced liver injury.

Medicine (Baltimore) 2022 Aug;101(32):e29909

Department of Infectious Diseases, Peking University First Hospital, Beijing, China.

The differences between Chinese herbal medicine (CHM)- and Western medicine (WM)-induced liver injury have rarely been reported. Our aim was to investigate the clinical features of patients with drug-induced liver injury (DILI) caused by CHM or WM. The medical records of 726 DILI patients were retrospectively collected at Peking University First Hospital from January 1995 through August 2019. Read More

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Natural Dietary Compounds in the Treatment of Arsenic Toxicity.

Molecules 2022 Jul 29;27(15). Epub 2022 Jul 29.

Department of Chemical, Physics, Mathematics and Natural Sciences, University of Sassari, Via Vienna 2, 07100 Sassari, Italy.

Chronic exposure to arsenic (As) compounds leads to its accumulation in the body, with skin lesions and cancer being the most typical outcomes. Treating As-induced diseases continues to be challenging as there is no specific, safe, and efficacious therapeutic management. Therapeutic and preventive measures available to combat As toxicity refer to chelation therapy, antioxidant therapy, and the intake of natural dietary compounds. Read More

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Diclofenac-Induced Cytotoxicity in Direct and Indirect Co-Culture of HepG2 Cells with Differentiated THP-1 Cells.

Int J Mol Sci 2022 Aug 4;23(15). Epub 2022 Aug 4.

Department of Pharmacy, Faculty of Pharmacy, Kindai University, 3-4-1 Kowakae, Higashiosaka 577-8502, Osaka, Japan.

Non-steroidal anti-inflammatory drugs (NSAIDs) such as diclofenac (DIC) frequently induce drug-induced liver injury (DILI). It is unclear whether macrophages such as M1 and M2 participate in NSAID-associated DILI; elucidating this relationship could lead to a better understanding of the detailed mechanism of DILI. We co-cultured human hepatoma HepG2 cells with M1 or M2 derived from human monocytic leukemia THP-1 cells to examine the roles of M1 and M2 in DIC-induced cytotoxicity. Read More

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Antipsychotic Drug Aripiprazole Protects Liver Cells from Oxidative Stress.

Int J Mol Sci 2022 Jul 27;23(15). Epub 2022 Jul 27.

University of Ljubljana, Faculty of Medicine, Institute of Pathophysiology, Zaloska 4, SI-1000 Ljubljana, Slovenia.

Antipsychotics used to treat schizophrenia can cause drug-induced liver injury (DILI), according to the Roussel Uclaf Causality Assessment Method. The role of oxidative stress in triggering injury in these DILI cases is unknown. We repeatedly administrated two second-generation antipsychotics, aripiprazole and olanzapine, at laboratory alert levels to study underlying mechanisms in stress prevention upon acute oxidative stress. Read More

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Expression and functional activity of cytochrome P450 enzymes in human hepatocytes with sustainable reproducibility for in vitro phenotyping studies.

Adv Pharmacol 2022 30;95:285-305. Epub 2022 Jun 30.

Central Institute for Experimental Animals, Kawasaki, Kanagawa, Japan.

Primary human hepatocytes are an essential in vitro tool for evaluating drug metabolism, drug-drug interactions, and hepatotoxicity. This model is considered as the gold standard in matter of DMPK studies in both industrial and academic research. The primary human hepatocytes are used either in suspension or in monolayer, as fresh or frozen cells. Read More

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Lethal toxicity induced by combined ingestion of dietary acetic acid and carbamazepine.

Drug Chem Toxicol 2022 Aug 11:1-5. Epub 2022 Aug 11.

Faculty of Medicine and Pharmacy, Research Centre in the Medical-Pharmaceutical Field, University "Dunarea de Jos", Galati, Romania.

Acetic acid is an organic acid that can be used in the food industry, which normally has an insignificant rate of adverse reactions when used rationally. However, irrational use can cause serious toxic effects and even death. In this context, the case of a death of a 52-year-old woman, involving the suspected voluntary use of food acetic acid, is presented, while toxicological and histopathological aspects were addressed for death mechanism elucidation. Read More

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Assessing potential liver injury induced by using potential biomarkers via targeted sphingolipidomics.

Pharm Biol 2022 Dec;60(1):1578-1590

Research Center of Chinese Medicine Analysis and Transformation, Beijing University of Chinese Medicine, Beijing, China.

Context: Thunb. (Polygonaceae) (PM) can cause potential liver injury which is typical in traditional Chinese medicines (TCMs)-induced hepatotoxicity. The mechanism involved are unclear and there are no sensitive evaluation indicators. Read More

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December 2022

Impact of cytochrome P450 2C19 polymorphisms on the clinical efficacy and safety of voriconazole: an update systematic review and meta-analysis.

Pharmacogenet Genomics 2022 Sep 21;32(7):257-267. Epub 2022 Jul 21.

Department of Pharmacy, Peking University People's Hospital, Beijing.

Objective: To assess the impact of cytochrome P450 (CYP) 2C19 polymorphisms on the clinical efficacy and safety of voriconazole.

Methods: We systematically searched PubMed, EMBASE, CENTRAL, ClinicalTrials.gov, and three Chinese databases from their inception to 18 March 2021 using a predefined search algorithm to identify relevant studies. Read More

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September 2022

Immune-checkpoint inhibitor-associated grade 3 hepatotoxicity managed with enteric-coated budesonide monotherapy: A case report.

Medicine (Baltimore) 2022 Aug;101(31):e29473

2nd Department of Internal Medicine, General Hospital of Nikaia-Piraeus "Agios Panteleimon," Athens, Greece.

Rationale: The introduction of immune-checkpoint inhibitors (ICPI) in recent years has changed the natural course of many neoplasms. However, patients receiving these medications may present immune-mediated adverse events; management includes temporary or permanent cessation of treatment and corticosteroids, occasionally combined with other immunomodulators. Such immunosuppression, however, also has numerous adverse events and even if it is effective in controlling toxicity, it delays immunotherapy reinitiation, as current evidence requires dose tapering to ≤10 mg prednisolone equivalent before rechallenge. Read More

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Apocynin loaded silver nanoparticles displays potent in vitro biological activities and mitigates pyrogallol-induced hepatotoxicity.

Chem Biol Interact 2022 Aug 6;365:110069. Epub 2022 Aug 6.

Department of Chemical Sciences, Faculty of Natural Sciences, Redeemer's University, Ede, Osun State, Nigeria.

Drug-loaded nanoparticles are currently gaining attention due to their improved drug delivery properties. Apocynin, a natural polyphenolic compound, is a component of many plants. It has many medicinal and pharmacological properties. Read More

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Metabolic competency of larval zebrafish in drug-induced liver injury: a case study of acetaminophen poisoning.

Toxicol Sci 2022 Aug 9. Epub 2022 Aug 9.

State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Taipa, Macao, China.

Larval zebrafish is emerging as a new model organism for studying drug-induced liver injury (DILI) with superiorities in visual assessment, genetic engineering as well as high throughput. Metabolic bioactivation to form reactive intermediates is a common event that triggers DILI. This study first addressed the correlation between acetaminophen metabolism and hepatotoxicity in zebrafish larvae (3 days post-fertilization) and demonstrated the occurrence of cytochrome P450 enzymes-mediated APAP bioactivation at early developmental stage through characterizing the dose-effect (0-1. Read More

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HO-Activated NIR-II Fluorescent Probe with a Large Stokes Shift for High-Contrast Imaging in Drug-Induced Liver Injury Mice.

Anal Chem 2022 Aug 7;94(32):11321-11328. Epub 2022 Aug 7.

Research Center for Analytical Sciences, Tianjin Key Laboratory of Biosensing and Molecular Recognition, College of Chemistry, Nankai University, Tianjin 300071, China.

Drug-induced liver injury (DILI) is the most common clinical adverse drug reaction, which is closely associated with the oxidative stress caused by overproduced reactive oxygen species. Hepatic HO, as an important biomarker of DILI, plays a crucial role in the progression of DILI. However, there remains a challenge to develop HO-activatable second near-infrared (NIR-II, 1000-1700 nm) small molecular probes with both a large Stokes shift and a long emission wavelength beyond 950 nm. Read More

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Emodin-induced hepatotoxicity is enhanced by 3-methylcholanthrene through activating aryl hydrocarbon receptor and inducing CYP1A1 in vitro and in vivo.

Chem Biol Interact 2022 Aug 5;365:110089. Epub 2022 Aug 5.

Guangdong Pharmaceutical University, Guangzhou, 510006, PR China; Jiangxi University of Traditional Chinese Medicine, Nanchang, 330004, PR China; Department of Pharmaceutical Sciences, Beijing Institute of Radiation Medicine, Beijing, 100850, PR China. Electronic address:

Background & Aims: Polygonum multiflorum Thunb. (PMT) is the most common traditional Chinese medicine used to treat multiple diseases, and the hepatotoxicity caused by PMT has made great concern around world. Recent results showed that emodin is the potential toxic components of PMT, but the molecular mechanisms of emodin on liver toxicity remain to be elucidated. Read More

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Unraveling the effect of intra- and intercellular processes on acetaminophen-induced liver injury.

NPJ Syst Biol Appl 2022 Aug 6;8(1):27. Epub 2022 Aug 6.

Division of Drug Discovery and Safety, Leiden Academic Centre for Drug Research, Leiden University, Einsteinweg 55, 2333 CC, Leiden, The Netherlands.

In high dosages, acetaminophen (APAP) can cause severe liver damage, but susceptibility to liver failure varies across individuals and is influenced by factors such as health status. Because APAP-induced liver injury and recovery is regulated by an intricate system of intra- and extracellular molecular signaling, we here aim to quantify the importance of specific modules in determining the outcome after an APAP insult and of potential targets for therapies that mitigate adversity. For this purpose, we integrated hepatocellular acetaminophen metabolism, DNA damage response induction and cell fate into a multiscale mechanistic liver lobule model which involves various cell types, such as hepatocytes, residential Kupffer cells and macrophages. Read More

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Colon targeted chitosan-melatonin nanotherapy for preclinical Inflammatory Bowel Disease.

Biomater Adv 2022 May 11;136:212796. Epub 2022 Apr 11.

Chemical Biology Unit, Institute of Nano Science and Technology (INST), Sector-81, Knowledge City, SAS Nagar, Punjab 140306, India. Electronic address:

Inflammatory Bowel (IBD) is an umbrella term which includes Crohn's Disease (CD) and Ulcerative Colitis (UC). At present, therapies available for management of the UC includes, corticosteroid, immuno-suppressants and antibiotics are used for mild to moderate UC conditions which can cause nephrotoxicity, hepatotoxicity and cardiotoxicity. Hence, a novel therapeutic candidate having potent anti-inflammatory effect is urgently warranted for the management of UC. Read More

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Changes in Epidemiology of Acetaminophen Overdoses in an Urban County Hospital After 20 Years.

Am J Gastroenterol 2022 Aug 5;117(8):1324-1328. Epub 2022 May 5.

Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA.

Introduction: Acetaminophen (APAP) toxicity is the main cause of acute liver failure in the United States. A prior series (1992-1995) identified 71 hospitalized adults with APAP toxicity through the International Statistical Classification of Disease and Related Health Problems, 9th revision (ICD-9) code at Parkland Hospital, Dallas, TX.

Methods: We used a laboratory database search of serum APAP levels from 2011 to 2015 to identify patients with APAP toxicity in the same hospital. Read More

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CREB is a potential marker associated with drug-induced liver injury: Identification and validation through transcriptome database analysis.

J Toxicol Sci 2022 ;47(8):337-348

Department of Drug Delivery Research, Graduate School of Pharmaceutical Sciences, Kyoto University.

Drug-induced liver injury (DILI) is the main cause of failure in drug development and postapproval withdrawal. Although toxicogenomic techniques provide an unprecedented opportunity for mechanistic assessment and biomarker discovery, they are not suitable for the screening of large numbers of exploratory compounds in early drug discovery. Using a comprehensive analysis of toxicogenomics (TGx) data, we aimed to find DILI-relevant transcription factors (TFs) that could be incorporated into a reporter gene assay system. Read More

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Landscape of lipidomic metabolites in gut-liver axis of Sprague-Dawley rats after oral exposure to titanium dioxide nanoparticles.

Part Fibre Toxicol 2022 Aug 3;19(1):53. Epub 2022 Aug 3.

Department of Occupational and Environmental Health Sciences, School of Public Health, Peking University, Beijing, 100191, China.

Background: The application of titanium dioxide nanoparticles (TiO NPs) as food additives poses a risk of oral exposure that may lead to adverse health effects. Even though the substantial evidence supported liver as the target organ of TiO NPs via oral exposure, the mechanism of liver toxicity remains largely unknown. Since the liver is a key organ for lipid metabolism, this study focused on the landscape of lipidomic metabolites in gut-liver axis of Sprague Dawley (SD) rats exposed to TiO NPs at 0, 2, 10, 50 mg/kg body weight per day for 90 days. Read More

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Chemopreventive effects of hesperidin against paclitaxel-induced hepatotoxicity and nephrotoxicity via amendment of Nrf2/HO-1 and caspase-3/Bax/Bcl-2 signaling pathways.

Chem Biol Interact 2022 Jul 31;365:110073. Epub 2022 Jul 31.

Department of Biochemistry, Faculty of Veterinary Medicine, Atatürk University, Erzurum, Turkey.

Paclitaxel (PTX) is a widely used chemotherapeutic drug particularly effective against lung, breast, and ovarian cancer, though its usefulness is limited due to its multi-organ toxicity. The mechanisms underlying PTX toxicity are currently not yet known and there are no approved treatments for its control or prevention. This study aimed to investigate whether hesperidin (HSP) had a protective effect on paclitaxel-induced hepatotoxicity and nephrotoxicity from biochemical, and molecular perspectives. Read More

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A review: Systematic research approach on toxicity model of liver and kidney in laboratory animals.

Animal Model Exp Med 2022 Aug 2. Epub 2022 Aug 2.

Department of Physiology, Faculty of Medicine, Gonabad University of Medical Sciences, Gonabad, Iran.

Therapeutic experiments are commonly performed on laboratory animals to investigate the possible mechanism(s) of action of toxic agents as well as drugs or substances under consideration. The use of toxins in laboratory animal models, including rats, is intended to cause toxicity. This study aimed to investigate different models of hepatotoxicity and nephrotoxicity in laboratory animals to help researchers advance their research goals. Read More

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