759 results match your criteria Drug-Induced Bullous Disorders


Treatment of oral manifestations of toxic epidermal necrolysis with low-level laser therapy in a pediatric patient.

Pediatr Dermatol 2019 Jan 26;36(1):e27-e30. Epub 2018 Nov 26.

Department of Oral Surgery and Pathology, Faculty of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.

Drug-induced reactions are complications associated with high mortality and significant morbidity. Stevens-Johnson Syndrome (SJS) and toxic epidermal necrolysis (TEN) are examples of these conditions, which are characterized by skin and mucous lesions. Here, we report a case of a 9-year-old girl who presented with blisters associated with an extensive vesicular rash and multiple ulcerations on the lips and oral cavity. Read More

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http://doi.wiley.com/10.1111/pde.13719
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http://dx.doi.org/10.1111/pde.13719DOI Listing
January 2019
12 Reads

Efficacy and adverse reactions of methotrexate in the treatment of ocular cicatricial pemphigoid: A case series study.

Medicine (Baltimore) 2018 Sep;97(38):e12338

Department of Ophthalmology, The Affiliated Guangren Hospital of Xi'an Jiaotong University.

The application of methotrexate (MTX) in the treatment of autoimmune diseases has been gradually increasing, but reports of MTX treatment for advanced ocular cicatricial pemphigoid (OCP) are extremely rare. This study investigated the efficacy and adverse reactions of low-dose MTX in patients with OCP.This was a retrospective, noncontrolled, case series study. Read More

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http://dx.doi.org/10.1097/MD.0000000000012338DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6160102PMC
September 2018
4 Reads

The influence of acute kidney injury on the outcome of Stevens-Johnson syndrome and toxic epidermal necrolysis: The prognostic value of KDIGO staging.

PLoS One 2018 7;13(9):e0203642. Epub 2018 Sep 7.

Kidney Research Center, Department of Nephrology, Change Gung Memorial Hospital, Linkou branch, Taoyuan, Taiwan.

Background: Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and SJS/TEN overlap syndrome are severe drug-induced cutaneous adverse reactions with high mortality. Acute kidney injury (AKI) was a common complication in an SJS/TEN group and noted as an independent risk factor for mortality in patients with SJS/TEN. To determine whether AKI staging can predict the outcome of patients with SJS/TEN, we compared the discriminative power of an AKI KDIGO staging system with that of SCROTEN, APACHE II, APACHE III, and SOFA. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0203642PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6128626PMC
February 2019
7 Reads
3.234 Impact Factor

Diffuse vesiculobullous eruption with systemic findings.

Dermatol Online J 2018 May 15;24(5). Epub 2018 May 15.

Naval Health Clinic Quantico, Quantico, Virginia.

Drug induced linear IgA bullous dermatosis (LABD) is a rare blistering disease that has been shown to be associated with the use of various medications. Although rarely seen together, some of the medications associated with LABD can lead to the syndrome drug reaction with eosinophilia and systemic symptoms (DRESS), which presents with fever, cutaneous eruption, and multi-organ involvement. We present a patient who developed fever and a generalized vesiculobullous eruption after recently starting amlodipine and meloxicam. Read More

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May 2018
18 Reads

MRSA in dermatology inpatients with a vesiculobullous disorder.

Cutis 2018 Jun;101(6):458-461

Department of Dermatology and Venereology, Government Medical College, Trivandrum, Kerala State, India.

Methicillin-resistant (MRSA) has emerged worldwide as a major nosocomial pathogen that causes notable morbidity and mortality, especially in vesiculobullous disorders. To study the prevalence of MRSA among patients with autoimmune bullous and drug-induced vesiculobullous disorders and elucidate its predisposing factors and associated mortality, we conducted a prospective, descriptive, 1-year study of all vesiculobullous patients admitted to a tertiary-care center. The prevalence of MRSA in this study was high (32. Read More

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June 2018
1 Read

Carbamazepine-induced Stevens-Johnson syndrome/toxic epidermal necrolysis overlap in a Filipino with positive HLA-B75 serotype.

BMJ Case Rep 2018 Jul 17;2018. Epub 2018 Jul 17.

Institute of Human Genetics, National Institutes of Health, University of the Philippines Manila, Manila, Philippines.

Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are two related mucocutaneous disorders with different severities. Although the incidence is low, SJS and TEN are life-threatening and predominantly drug-induced conditions. There is a strong relationship between the allele and carbamazepine-induced SJS and TEN in different Southeast Asian populations. Read More

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http://dx.doi.org/10.1136/bcr-2018-225028DOI Listing
July 2018
4 Reads

Adverse Immunologically Mediated Oral Mucosal Reactions to Systemic Medication: Lichenoid Tissue Reaction/Interface Dermatitis-Stomatitis, Autoimmune Vesiculobullous Disease, and IgE-Dependent and Immune Complex Reactions.

J Immunol Res 2018 10;2018:7645465. Epub 2018 Jun 10.

Department of Periodontology and Oral Medicine, Sefako Makgatho Health Sciences University, Pretoria, South Africa.

Drug-induced hypersensitivity immune reactions are exaggerated immunoinflammatory responses to allergenic components of the medications that occur in genetically susceptible subjects. The type of hypersensitivity immune response generated, whether antibody mediated or T cell mediated, or an immune complex reaction is determined by multiple factors, including the molecular characteristics of the allergen, the route of administration of the medication, the manner of presentation of the allergen by antigen-presenting cells to naïve T cells, the repertoire of the T cell receptors, and the cytokine profile within the microenvironment. This review deals with the clinical and histopathological aspects of adverse immunologically mediated oral mucosal reactions to systemic medication. Read More

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http://dx.doi.org/10.1155/2018/7645465DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6015680PMC
October 2018
5 Reads

Clinical features of Stevens-Johnson syndrome and toxic epidermal necrolysis.

Pediatr Int 2018 Aug 30;60(8):697-702. Epub 2018 Jul 30.

Division of Infectious Diseases and Immunology, Saitama Children's Medical Center, Saitama, Japan.

Background: Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare, but these conditions are associated with high mortality. There have been few reports of SJS and TEN in children. The aim of this study was to evaluate the clinical features and outcomes of SJS and TEN in a group of Japanese children. Read More

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http://dx.doi.org/10.1111/ped.13613DOI Listing
August 2018
14 Reads

Drug-induced linear IgA bullous dermatosis in a patient with a vancomycin-impregnated cement spacer.

Cutis 2018 Apr;101(4):293-296

Division of Dermatology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.

Linear IgA bullous dermatosis (LABD) is an autoimmune blistering rash caused by IgA autoantibodies against the epidermal basement membrane zone. It commonly is drug induced, often in association with systemic vancomycin. We report a case of a previously healthy 77-year-old man who developed a diffuse macular rash and hemorrhagic bullae on the left leg 10 days after placement of a vancomycin-impregnated cement spacer (VICS) during a revision knee arthroplasty and initiation of postoperative treatment with intravenous (IV) vancomycin. Read More

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April 2018
4 Reads

The devil's in the dosing: severe drug-induced liver injury in a hydroxychloroquine-naive patient with subacute cutaneous lupus erythematosus and porphyria cutanea tarda.

Lupus 2018 Jul 9;27(8):1383-1386. Epub 2018 Apr 9.

1 Division of Rheumatology, University of Michigan Medical School, USA.

A 29-year-old woman with a 1.5 year history of photosensitive skin lesions on her hands presented with a malar rash, bullous lesions on her hands, and was diagnosed with subacute lupus erythematosus after serologies revealed a positive antinuclear antibody test (1:2560), and antibodies to Ro/SSA and dsDNA. Hydroxychloroquine (400 mg/day) was prescribed and the patient developed severe drug-induced liver injury. Read More

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http://dx.doi.org/10.1177/0961203318768884DOI Listing
July 2018
6 Reads

Trimethoprim-sulfamethoxazole-induced linear IgA bullous disease presenting as toxic epidermal necrolysis.

Dermatol Online J 2017 Aug 15;23(8). Epub 2017 Aug 15.

Department of Dermatology, Hôpital Nord, University of Amiens, Amiens, France.

Background: Linear IgA bullous dermatosis (LABD) is an autoimmune blistering skin disorder characterized by linear IgA deposits along the dermoepidermal junction. Usually idiopathic, LABD can be drug-induced.

Objective: To report the atypical characteristics of a case of trimethoprim-sulfamethoxazole-induced LABD presenting as toxic epidermal necrolysis (TEN). Read More

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August 2017
2 Reads

Flame figures in linear IgA bullous dermatosis: a novel histopathologic finding.

Dermatol Online J 2017 Nov 15;23(11). Epub 2017 Nov 15.

Beth Israel Deaconess Medical Center, Department of Pathology, Harvard Medical School, Boston, Massachusetts.

Background: Linear IgA bullous dermatosis (LABD) is an autoimmune subepidermal blistering disease usually with a neutrophil rich inflammatory infiltrate, and characterized by linear IgA deposition at the basement membrane zone (BMZ), and neutrophil predominant dermal inflammation. We report a case of LABD with numerous eosinophils and flame figure formation, a unique histopathologic finding not previously reported. A 69-year-old woman presented with a rapidly progressive, intensely pruritic rash over forearms, breasts, axillae, hips, and thighs. Read More

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November 2017
1 Read

Ethosuximide-induced Stevens-Johnson syndrome: Beneficial effect of early intervention with high-dose corticosteroid therapy.

J Dermatol 2018 May 11;45(5):592-595. Epub 2018 Feb 11.

Department ofDermatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan.

We report two rare cases of childhood epilepsy patients who developed ethosuximide-induced Stevens-Johnson syndrome (SJS). Unlike typical SJS, the initial eruption of both patients presented well-demarcated, infiltrating firm papules mainly on the cheeks and the extensor aspects of the arms (case 1), and multiple vesicles on the soles and oral aphthosis (case 2), which closely mimicked viral exanthema. We diagnosed both patients with ethosuximide-induced SJS, based on the dosing period and the positive results of drug-induced lymphocyte stimulation test. Read More

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http://dx.doi.org/10.1111/1346-8138.14253DOI Listing
May 2018
3 Reads

Drug-induced oral erythema multiforme: A diagnostic challenge.

Authors:
Syed Ahmed Taqi

Ann Afr Med 2018 Jan-Mar;17(1):43-45

Department of Oral and Maxillofacial Surgery Sciences, Division of Oral Pathology and Microbiology, Najran University College of Dentistry, Najran, Saudi Arabia.

Trimethoprim-sulfamethoxazole (cotrimoxazole or TMP/SMX) is commonly used for the treatment of urinary or lower respiratory tract infections. A comprehensive review is presented of the world literature on adverse reactions to TMP/SMX since its first use in 1968, when concern was expressed about possible hematologic toxicity. The adverse reactions to TMP/SMX occur in approximately 1%-3% of persons in general population. Read More

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http://dx.doi.org/10.4103/aam.aam_19_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5810093PMC
June 2018
5 Reads

[Histopathology of cutaneous drug reactions].

Authors:
Nicolas Ortonne

Ann Pathol 2018 Feb 24;38(1):7-19. Epub 2017 Dec 24.

Département de pathologie, hôpital Henri-Mondor, 51, avenue du Maréchal-de-Lattre-de-Tassigny, 94010 Créteil, France. Electronic address:

There are many different types of cutaneous adverse reactions. The most classical reactions are driven by T lymphocytes that specifically react towards a drug, with an individual genetic susceptibility linked to certain type I major histocompatibility complex alleles. These reactions are characterized by a wide variety of clinical and histopathological presentations, and a wide range of severity. Read More

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http://dx.doi.org/10.1016/j.annpat.2017.10.015DOI Listing
February 2018
5 Reads

Long-term mucocutaneous adverse effects of imatinib in Indian chronic myeloid leukemia patients.

Int J Dermatol 2018 Mar 20;57(3):332-338. Epub 2017 Dec 20.

Department of Hematology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Background: Short-term mucocutaneous adverse effects are well documented with imatinib. However, studies on long-term adverse effects and in the ethnic population are lacking.

Objective: To study the long-term mucocutaneous adverse effects of imatinib and factors predicting these adverse effects. Read More

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http://dx.doi.org/10.1111/ijd.13852DOI Listing
March 2018
12 Reads
1.230 Impact Factor

Immunohistopathological Findings of Severe Cutaneous Adverse Drug Reactions.

Authors:
Mari Orime

J Immunol Res 2017 31;2017:6928363. Epub 2017 Oct 31.

Division of Dermatology, Niigata University Graduate School of Medical and Dental Sciences, 1-757 Asahimachi-dori, Chuo-ku, Niigata 951-8510, Japan.

Diagnosis of severe cutaneous adverse drug reactions should involve immunohistopathological examination, which gives insight into the pathomechanisms of these disorders. The characteristic histological findings of erythema multiforme (EM), Stevens-Johnson syndrome (SJS), and toxic epidermal necrolysis (TEN) provide conclusive evidence demonstrating that SJS/TEN can be distinguished from EM. Established SJS/TEN shows full-thickness, extensive keratinocyte necrosis that develops into subepidermal bullae. Read More

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http://dx.doi.org/10.1155/2017/6928363DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5684554PMC
August 2018
12 Reads

Pemphigus trigger factors: special focus on pemphigus vulgaris and pemphigus foliaceus.

Arch Dermatol Res 2018 Mar 6;310(2):95-106. Epub 2017 Nov 6.

Skin Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Pemphigus is a general term for a rare group of autoimmune diseases which result in the formation of blisters on the skin and oral cavity. Although there is no way to prevent autoimmune diseases, some factors may trigger pemphigus initiation in susceptible individuals or be exacerbated in affected patients. Recognition of these triggers, based on the latest studies and experiences is essential and should be updated every few years. Read More

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http://dx.doi.org/10.1007/s00403-017-1790-8DOI Listing
March 2018
6 Reads

Other Forms of Esophagitis: It Is Not Gastroesophageal Reflux Disease, So Now What Do I Do?

Surg Pathol Clin 2017 Dec 23;10(4):765-779. Epub 2017 Sep 23.

Department of Pathology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10467, USA. Electronic address:

Esophagitis results from diverse causes, including gastroesophageal reflux, immune-mediated or allergic reactions, therapeutic complications, and infections. The appropriate clinical management differs in each of these situations and is often guided by pathologic interpretation of endoscopic mucosal biopsy specimens. This review summarizes the diagnostic features of unusual forms of esophagitis, including eosinophilic esophagitis, lymphocytic esophagitis, esophagitis dissecans superficialis, drug-induced esophageal injury, and bullous disorders. Read More

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http://dx.doi.org/10.1016/j.path.2017.07.001DOI Listing
December 2017
2 Reads

Strange case of dimorphic skin rash in a patient with cirrhosis: atypical herpes simplex and sweet's syndrome.

BMJ Case Rep 2017 Oct 20;2017. Epub 2017 Oct 20.

Department of Gastroenterology, PVS Memorial Hospital, Cochin, Kerala, India.

A middle-aged man with decompensated cirrhosis and a dimorphic multisite skin rash is diagnosed with rare atypical herpes simplex infection, manifesting Sweet's syndrome (SS) in the absence of other described associations. SS, an acute febrile neutrophilic dermatosis, has three common forms-classical or idiopathic, malignancy associated and drug induced. Systemic autoimmune, connective tissue diseases and infections are also strong associations. Read More

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http://dx.doi.org/10.1136/bcr-2017-220743DOI Listing
October 2017
12 Reads

Serum IL-17 in patients with erythema multiforme or Stevens-Johnson syndrome/toxic epidermal necrolysis drug reaction, and correlation with disease severity.

Clin Exp Dermatol 2017 Dec 20;42(8):868-873. Epub 2017 Sep 20.

Department of Dermatology, Venereology and Andrology , Assiut University, Egypt.

Background: There is strong evidence that drug-induced cutaneous eruptions have an immunological component. Interleukin (IL)-17, a proinflammatory cytokine that is predominantly produced by T helper 17 cells, has been linked to various autoimmune and inflammatory diseases.

Aim: To measure serum IL-17 levels in patients with cutaneous drug reactions [erythema multiforme (EM) and Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN)] in order to study the associations between IL-17 and disease severity. Read More

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http://dx.doi.org/10.1111/ced.13213DOI Listing
December 2017
4 Reads

[Clinical characteristics and prognosis for 126 patients with severe drug eruption].

Zhong Nan Da Xue Xue Bao Yi Xue Ban 2017 Aug;42(8):953-957

Department of Dermatology, Xiangya Hospital, Central South University, Changsha 410008, China.

Objective: To explore the clinical characteristics of various types of severe drug eruption and common sensitized drugs, and to provide clinical references for reducing the incidence of severe drug eruption.
 Methods: The clinical data regarding 126 cases of severe drug eruption were analyzed retrospectively from June 2009 to May 2017 in Xiangya Hospital, Central South University.
 Results: In the 126 cases of severe drug eruption, the distribution of men and women ratio was 1:1. Read More

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http://dx.doi.org/10.11817/j.issn.1672-7347.2017.08.013DOI Listing

Effect of Infectious Diseases on the Pathogenesis of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis.

Biol Pharm Bull 2017 ;40(9):1576-1580

Division of Medicinal Safety Science, National Institute of Health Sciences.

Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are severe cutaneous adverse drug reactions. Recent studies have revealed that the prevalence of SJS/TEN is associated with genetic backgrounds, such as polymorphisms in human leukocyte antigens (HLAs). However, non-genetic factors contributing to the etiology of SJS/TEN are largely unknown. Read More

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http://dx.doi.org/10.1248/bpb.b17-00207DOI Listing
May 2018
8 Reads

Comparison of the acute ocular manifestations of Stevens-Johnson syndrome and toxic epidermal necrolysis in Chinese eyes: a 15-year retrospective study.

BMC Ophthalmol 2017 May 12;17(1):65. Epub 2017 May 12.

Department of Ophthalmology, The University of Hong Kong, Room 301, Level 3, Block B, Cyberport 4, 100 Cyberport Road, Pok Fu Lam, Hong Kong.

Background: Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare but life-threatening conditions that initially affect the skin and mucous membranes. The aim of this study was to compare the acute ocular manifestations between SJS and TEN.

Methods: The initial presenting ophthalmic records of patients with either SJS (<30% body surface area involvement) or TEN (> = 30% involvement), who were treated at one tertiary burn center in Hong Kong between 1999 and 2014, were retrospectively analyzed and compared. Read More

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http://dx.doi.org/10.1186/s12886-017-0464-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5427612PMC
May 2017
18 Reads

HLA-A*24:02 as a common risk factor for antiepileptic drug-induced cutaneous adverse reactions.

Neurology 2017 Jun 5;88(23):2183-2191. Epub 2017 May 5.

Author affiliations are provided at the end of the article.

Objective: To investigate the involvement of human leukocyte antigen (HLA) loci in aromatic antiepileptic drug-induced cutaneous adverse reactions.

Methods: A case-control study was performed to detect HLA loci involved in aromatic antiepileptic drug-induced Stevens-Johnson syndrome in a southern Han Chinese population. Between January 1, 2006, and December 31, 2015, 91 cases of Stevens-Johnson syndrome induced by aromatic antiepileptic drugs and 322 matched drug-tolerant controls were enrolled from 8 centers. Read More

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http://dx.doi.org/10.1212/WNL.0000000000004008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5467955PMC
June 2017
32 Reads

Effectiveness, safety and tolerability of cyclosporine versus supportive treatment in Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis: A record-based study.

Indian J Dermatol Venereol Leprol 2017 May-Jun;83(3):312-316

Department of Dermatology, Medical College and Hospital, Kolkata, West Bengal, India.

Background: Toxic epidermal necrolysis and Stevens-Johnson syndrome comprise life-threatening, drug-induced mucocutaneous disease spectrum. Interest in cyclosporine, a calcineurin inhibitor that can block the function of T-cells, has increased with the discovery of the importance of granulysin in apoptosis in toxic epidermal necrolysis. In our hospital, cyclosporine is given to Stevens-Johnson syndrome/toxic epidermal necrolysis patients as an adjunctive therapy. Read More

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http://dx.doi.org/10.4103/ijdvl.IJDVL_201_16DOI Listing
March 2018
15 Reads

Plasmapheresis, Intravenous Immunoglobulins, and Autologous Serum Eyedrops in the Acute Eye Complications of Toxic Epidermal Necrolysis.

Eur J Ophthalmol 2017 Nov;27(6):658-663

1 Section of Ophthalmology, Department of Surgical, Microsurgical, and Medical Sciences, University of Sassari, Sassari - Italy.

Purpose: Toxic epidermal necrolysis (TEN) is a rare, life-threatening, drug-induced, mucocutaneous disease, which can severely affect the ocular surface. The purpose of this study was to investigate the efficacy of plasmapheresis, human IV immunoglobulins (IVIg), and autologous serum (AS) eyedrops in the treatment of the severe acute ocular complications of TEN.

Methods: A retrospective chart review of all patients admitted to the Burn Unit, Azienda Ospedaliero-Universitaria-Sassari, Sassari, Italy, from 2009 to 2015, identified 9 patients (2 men, 7 women; mean age 63. Read More

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http://journals.sagepub.com/doi/10.5301/ejo.5000923
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http://dx.doi.org/10.5301/ejo.5000923DOI Listing
November 2017
7 Reads

Vancomycin-associated linear IgA disease mimicking toxic epidermal necrolysis.

An Bras Dermatol 2016 Sep-Oct;91(5 suppl 1):35-38

Universidade Federal de São Paulo (Unifesp) - São Paulo (SP), Brazil.

Linear IgA dermatosis is a rare subepidermal autoimmune blistering disease characterized by linear deposition of IgA along the basement membrane zone. In the last three decades, many different drugs have been associated with the drug-induced form of the disease, especially vancomycin. We report a case of vancomycin-induced linear IgA disease mimicking toxic epidermal necrolysis. Read More

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http://dx.doi.org/10.1590/abd1806-4841.20164665DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5324987PMC
July 2017
9 Reads

Unexpected recalcitrant course of drug-induced erythema multiforme-like eruption and interstitial pneumonia sequentially occurring after nivolumab therapy.

J Dermatol 2017 Jul 11;44(7):818-821. Epub 2017 Mar 11.

Department of Dermatology, Keio University School of Medicine, Tokyo, Japan.

Vemurafenib improves survival of melanoma patients. However, cutaneous side-effects commonly occur in them. Nivolumab and ipilimumab are monoclonal antibodies against programmed death 1 and cytotoxic T-lymphocyte-associated antigen 4, both of which regulate excessive T-cell activation. Read More

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http://dx.doi.org/10.1111/1346-8138.13810DOI Listing
July 2017
8 Reads

Pharmacogenomic Advances in the Prediction and Prevention of Cutaneous Idiosyncratic Drug Reactions.

Clin Pharmacol Ther 2017 07 3;102(1):86-97. Epub 2017 Jun 3.

Department of Dermatology, Drug Hypersensitivity Clinical and Research Center, Chang Gung Memorial Hospital, Taipei, Linkou, Taiwan.

Cutaneous idiosyncratic drug reactions (CIDRs) are usually unpredictable, ranging from mild maculopapular exanthema (MPE) to severe cutaneous adverse drug reactions (SCARs) such as drug reaction with eosinophilia and systemic symptoms (DRESS), Stevens-Johnson syndrome (SJS), and toxic epidermal necrolysis (TEN). Increasing evidence suggests that HLA alleles are strongly associated with drug-induced-CIDRs. The pathomechanisms for CIDRs include genetic polymorphisms affecting complex immune-specific HLA/drug antigen/T-cell receptor interactions and drug metabolism. Read More

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http://dx.doi.org/10.1002/cpt.683DOI Listing

A Review of the Pathogenesis of Toxic Epidermal Necrolysis.

J Nippon Med Sch 2016 ;83(6):216-222

Department of Dermatology, Nippon Medical School.

Toxic epidermal necrolysis (TEN) is a rare skin condition, most often drug-induced, known for its skin detachment and high mortality. In general, acute TEN is considered a T-cell mediated, type IV hypersensitivity disorder. It mostly results from a cumulative effect of risks from the drug structure, drug metabolism, HLA alleles and T cell clonotypes. Read More

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https://www.jstage.jst.go.jp/article/jnms/83/6/83_216/_artic
Publisher Site
http://dx.doi.org/10.1272/jnms.83.216DOI Listing
June 2017
9 Reads

Piperacillin-tazobactam-induced linear IgA bullous dermatosis presenting clinically as Stevens-Johnson syndrome/toxic epidermal necrolysis overlap.

Clin Exp Dermatol 2017 Apr 13;42(3):299-302. Epub 2017 Jan 13.

Department of Dermatology, Alfred Hospital, Melbourne, VIC, Australia.

Linear IgA bullous dermatosis (LABD) is a subepidermal autoimmune bullous disease characterized by linear IgA deposition at the basement membrane zone, which is visualized by direct immunofluorescence. Patients with LABD typically present with widespread vesicles and bullae; however, this is not necessarily the case, as the clinical presentation of this disease is heterogeneous. LABD clinically presenting as Stevens-Johnson syndrome (SJS) or toxic epidermal necrolysis (TEN) is an infrequent, yet well-described phenomenon. Read More

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http://dx.doi.org/10.1111/ced.13030DOI Listing
April 2017
5 Reads

Review of Toxic Epidermal Necrolysis.

Int J Mol Sci 2016 Dec 18;17(12). Epub 2016 Dec 18.

Dermatology Department, Royal North Shore Hospital, 2065 Sydney, Australia.

Toxic epidermal necrolysis (TEN) is a rare but life threatening mucocutaneous reaction to drugs or their metabolites. It is characterised by widespread keratinocyte apoptosis and sloughing of the skin, erosions of the mucous membranes, painful blistering, and severe systemic disturbance. The pathophysiology of TEN is incompletely understood. Read More

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http://dx.doi.org/10.3390/ijms17122135DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5187935PMC
December 2016
15 Reads

Photodermatoses: Kids are not just little people.

Clin Dermatol 2016 Nov - Dec;34(6):724-735. Epub 2016 Jul 12.

University of Connecticut School of Medicine, Department of Dermatology, Farmington, CT.

Photodermatoses are a group of skin disorders caused by abnormal reaction to ultraviolet radiation. Photodermatoses are divided into four groups: (1) immunologically mediated photodermatoses; (2) chemical- and drug-induced photodermatoses; (3) photoaggravated dermatoses; and (4) hereditary photodermatoses. This contribution discusses differences in the approach and diagnosis of pediatric and adult patients with suspected photodermatoses, focusing on immunologically mediated photodermatoses and chemical- and drug-induced photodermatoses. Read More

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http://dx.doi.org/10.1016/j.clindermatol.2016.07.007DOI Listing
June 2017
11 Reads

Acral manifestations of systemic diseases: Drug-induced and infectious diseases.

Clin Dermatol 2017 Jan - Feb;35(1):55-63. Epub 2016 Sep 10.

Department of Dermatology, Second University of Naples, Naples, Italy.

Drug reactions and systemic diseases often involve the skin. In particular, most drug-induced reactions and many infectious diseases present with dermatologic manifestations localized acrally, that is on distal portions of limbs (hand, foot) and head (ears, nose). A detailed review of all acral dermatologic signs of drug reactions and systemic diseases is beyond the scope of this paper, although some of these disorders will be discussed specifically here. Read More

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http://dx.doi.org/10.1016/j.clindermatol.2016.09.008DOI Listing
June 2017
4 Reads

Plasma Lipid Profiling of Patients with Chronic Ocular Complications Caused by Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis.

PLoS One 2016 29;11(11):e0167402. Epub 2016 Nov 29.

Division of Medical Safety Science, National Institute of Health Sciences, Setagaya, Tokyo, Japan.

Stevens-Johnson syndrome (SJS) and its severe variant, toxic epidermal necrolysis (TEN), are drug-induced acute inflammatory vesiculobullous reactions of the skin and mucous membranes, including the ocular surface. Even after recovery from skin symptoms, some SJS/TEN patients continue to suffer with severe ocular complications (SOCs). Therefore, this study aims to understand the pathophysiology of chronic SOCs. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0167402PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5127552PMC
June 2017
6 Reads

Treatment of antiviral-resistant recurrent erythema multiforme with dapsone.

Dermatol Ther 2017 Mar 18;30(2). Epub 2016 Nov 18.

Department of Dermatology, University of Alabama at Birmingham, Birmingham, AL.

Recurrent erythema multiforme (REM) is a chronic disease characterized by frequent episodes of target cutaneous lesions in an acral distribution. Conventional treatment includes systemic corticosteroids and antiviral therapy. The aim of this study was to evaluate dapsone as a potential steroid sparing-agent for the treatment of REM after a failed trial of at least one antiviral therapy (acyclovir, famciclovir, or valacyclovir). Read More

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http://dx.doi.org/10.1111/dth.12449DOI Listing
March 2017
10 Reads

In vitro test to confirm diagnosis of allopurinol-induced severe cutaneous adverse reactions.

Br J Dermatol 2016 Nov 29;175(5):994-1002. Epub 2016 Aug 29.

Division of Dermatology, Department of Medicine, Phramongkutklao Hospital, Phramongkutklao College of Medicine, Bangkok, Thailand.

Background: Allopurinol is a frequent cause of severe cutaneous adverse reactions (SCARs), such as drug reaction with eosinophilia and systemic symptoms (DRESS), Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). The reactions can potentially be fatal. As drug rechallenge in patients with a history of drug-induced SCARs is contraindicated, in vitro testing may have a diagnostic role as a confirmation test. Read More

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http://dx.doi.org/10.1111/bjd.14701DOI Listing
November 2016
3 Reads

Causative drug detection by drug-induced lymphocyte stimulation test in drug-induced linear IgA bullous dermatosis.

Br J Dermatol 2016 Nov 23;175(5):1106-1108. Epub 2016 Aug 23.

Department of Dermatology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, Aichi, 466-8550, Japan.

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http://doi.wiley.com/10.1111/bjd.14069
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http://dx.doi.org/10.1111/bjd.14069DOI Listing
November 2016
5 Reads

Drug-induced bullous pemphigoid.

J Gen Intern Med 2016 11 11;31(11):1393-1394. Epub 2016 Apr 11.

Department of Internal Medicine, Baylor College of Medicine, Houston, TX, USA.

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http://dx.doi.org/10.1007/s11606-016-3679-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5071269PMC
November 2016
2 Reads

The Importance of Patient-Specific Factors for Hepatic Drug Response and Toxicity.

Int J Mol Sci 2016 Oct 12;17(10). Epub 2016 Oct 12.

Section of Pharmacogenetics, Department of Physiology and Pharmacology, Karolinska Institutet, SE-17177 Stockholm, Sweden.

Responses to drugs and pharmacological treatments differ considerably between individuals. Importantly, only 50%-75% of patients have been shown to react adequately to pharmacological interventions, whereas the others experience either a lack of efficacy or suffer from adverse events. The liver is of central importance in the metabolism of most drugs. Read More

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http://dx.doi.org/10.3390/ijms17101714DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5085745PMC
October 2016
8 Reads

Leading articles in medical journals in 1966.

Br J Hosp Med (Lond) 2016 Oct;77(10):575-577

ST7 in Clinical Pharmacology and Acute Medicine, University College London, London.

The British Journal of Hospital Medicine is 50 years old. This article takes a look back at articles published during the year of its inception from the British Medical Journal, the Lancet and the Journal of the American Medical Association. Read More

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http://dx.doi.org/10.12968/hmed.2016.77.10.575DOI Listing
October 2016
5 Reads

Drug-induced Stevens-Johnson syndrome and toxic epidermal necrolysis in children: 20 years study in a tertiary care hospital.

World J Pediatr 2017 Jun 20;13(3):255-260. Epub 2016 Sep 20.

Pediatric Department, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.

Background: Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are severe lifethreatening skin conditions. The most common cause of these manifestations is medications. Beside discontinued of the culprit drug, systemic corticosteroids were used as a primary treatment option among pediatric population. Read More

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http://dx.doi.org/10.1007/s12519-016-0057-3DOI Listing
June 2017
14 Reads
1 Citation

Vancomycin-induced linear IgA bullous dermatosis: associations.

Dermatol Online J 2016 Apr 18;22(4). Epub 2016 Apr 18.

Coimbra University Hospital, Coimbra.

Unlabelled: Linear IgA bullous dermatosis (LABD) is a rare autoimmune blistering disease. LABD is considered mostly idiopathic, butsome cases have been reported to be drug-induced, mainly associated with vancomycin (VCM).We present two cases of LABD possibly associated with VCM used for cardiac surgery prophylaxis; in the presented cases, the eruptions occurred only after VCM withdrawal, therefore leaving a question about the relationship between VCM and LABD in these cases. Read More

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April 2016
12 Reads

[Mucosal diseases from an allergological perspective].

Hautarzt 2016 Oct;67(10):780-785

Univ. Klinik für Dermatologie, LKH Graz, Auenbruggerplatz 8, 8036, Graz, Österreich.

The oral allergy syndrome is one of the most common form of food allergy and manifests as contact urticaria of the oral mucosa after consumption of cross reacting foods. Whereas allergic contact stomatitis often occurs due to dental materials, allergic contact cheilitis is usually a reaction due to topical therapeutics like herpes ointments or lip care products. As late type reactions are more frequent than immediate type reactions in the anogenital mucosa, contact dermatitis in this area should be identified via epicutaneous testing. Read More

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http://link.springer.com/10.1007/s00105-016-3866-3
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http://dx.doi.org/10.1007/s00105-016-3866-3DOI Listing
October 2016
24 Reads

HLA and Delayed Drug-Induced Hypersensitivity.

Int Arch Allergy Immunol 2016 26;170(3):163-79. Epub 2016 Aug 26.

Laboratory of Immunology, Basic and Clinical Immunology Unit, Faculty of Medicine, University of Porto, Porto, Portugal.

Delayed drug allergy reactions (DDAR) are potentially fatal. Certain human leukocyte antigen (HLA) alleles have been associated with delayed allergy reactions following the administration of particular drugs. Examples are HLA-B*57:01 (abacavir), HLA-B*15:02/HLA-A*31:01 (carbamazepine), and HLA-B*58:01 (allopurinol). Read More

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http://dx.doi.org/10.1159/000448217DOI Listing
February 2017
29 Reads

Evaluation of Lymphocyte Transformation Test Results in Patients with Delayed Hypersensitivity Reactions following the Use of Anticonvulsant Drugs.

Int Arch Allergy Immunol 2016 25;170(3):158-62. Epub 2016 Aug 25.

Department of Immunology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Background/aim: Administration of the anticonvulsant drugs phenobarbital, phenytoin, carbamazepine and lamotrigine can be associated with severe hypersensitivity reactions. The lymphocyte transformation test (LTT) is a method to determine which drug has caused the hypersensitivity reaction. This study was done to evaluate the results of LTT in patients with delayed hypersensitivity reactions following the administration of anticonvulsants. Read More

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http://dx.doi.org/10.1159/000448284DOI Listing
February 2017
24 Reads
2 Citations
2.673 Impact Factor

Atypical pityriasis rosea: clinical evaluation of 27 patients.

Cutan Ocul Toxicol 2017 Jun 26;36(2):157-162. Epub 2016 Sep 26.

b Yildirim Beyazit University, Medical Faculty , Department of Dermatology , Ankara , Turkey.

Background: Pityriasis rosea (PR) is a common, acute, self-limiting inflammatory skin disease. It can easily be recognized with its typical clinical presentation. However, unusual clinic presentations can cause difficulty in diagnosis. Read More

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https://www.tandfonline.com/doi/full/10.1080/15569527.2016.1
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http://dx.doi.org/10.1080/15569527.2016.1225217DOI Listing
June 2017
39 Reads