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    704 results match your criteria Drug-Induced Bullous Disorders

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    HLA and Delayed Drug-Induced Hypersensitivity.
    Int Arch Allergy Immunol 2016 26;170(3):163-79. Epub 2016 Aug 26.
    Laboratory of Immunology, Basic and Clinical Immunology Unit, Faculty of Medicine, University of Porto, Porto, Portugal.
    Delayed drug allergy reactions (DDAR) are potentially fatal. Certain human leukocyte antigen (HLA) alleles have been associated with delayed allergy reactions following the administration of particular drugs. Examples are HLA-B*57:01 (abacavir), HLA-B*15:02/HLA-A*31:01 (carbamazepine), and HLA-B*58:01 (allopurinol). Read More

    Evaluation of Lymphocyte Transformation Test Results in Patients with Delayed Hypersensitivity Reactions following the Use of Anticonvulsant Drugs.
    Int Arch Allergy Immunol 2016 25;170(3):158-62. Epub 2016 Aug 25.
    Department of Immunology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
    Background/aim: Administration of the anticonvulsant drugs phenobarbital, phenytoin, carbamazepine and lamotrigine can be associated with severe hypersensitivity reactions. The lymphocyte transformation test (LTT) is a method to determine which drug has caused the hypersensitivity reaction. This study was done to evaluate the results of LTT in patients with delayed hypersensitivity reactions following the administration of anticonvulsants. Read More

    Azathioprine-induced bullous Sweet's syndrome: a rare association.
    BMJ Case Rep 2016 Apr 18;2016:10.1136/bcr-2016-215192. Epub 2016 Apr 18.
    Department of Dermatology & Venereology, Midnapore Medical College & Hospital, Midnapore, West Bengal, India.
    A 52-year-old man presented with high-grade fever, headache and painful vesicular skin rash involving the upper trunk and upper extremities, 8 days after initiation of chemotherapy with azathioprine (50 mg/day), which had been prescribed for acral vitiligo. There was neither any history of preceding respiratory or gastrointestinal tract infection, nor was the patient known to have malignancy, drug hypersensitivity, inflammatory bowel disease, vasculitis or other autoimmune disease. Laboratory results revealed leucocytosis with neutrophilia and markedly elevated acute phase reactants. Read More

    [Aphthous ulcers and oral ulcerations].
    Presse Med 2016 Feb 12;45(2):215-26. Epub 2016 Feb 12.
    CHRU de Tours, université François-Rabelais de Tours, hôpital Trousseau, Inra, service de dermatologie, 37044 Tours cedex 01, France.
    Aphthous ulcers are painful ulcerations located on the mucous membrane, generally in the mouth, less often in the genital area. Three clinical forms of aphthous ulcers have been described: minor aphthous ulcers, herpetiform aphthous ulcers and major aphthous ulcers. Many other conditions presenting with oral bullous or vesiculous lesions orulcerations and erosions can be mistaken for aphthous ulcers. Read More

    Rare extrapulmonary complications of Mycoplasma pneumoniae infection.
    BMJ Case Rep 2016 Feb 1;2016. Epub 2016 Feb 1.
    St Georges NHS Trust, London, UK.
    Stevens-Johnsons syndrome (SJS) is a rare extra-pulmonary complication of Mycoplasma pneumoniae infection. We present the case of a 26-year-old man with fever, cough, extensive oral mucosal ulceration and a widespread truncal rash. He was diagnosed with M. Read More

    HLA Allele Frequencies in 5802 Koreans: Varied Allele Types Associated with SJS/TEN According to Culprit Drugs.
    Yonsei Med J 2016 Jan;57(1):118-26
    Division of Allergy and Immunology, Department of Internal Medicine, Institute of Allergy, Yonsei University College of Medicine, Seoul, Korea.
    Purpose: Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are very serious forms of drug-induced cutaneous adverse reaction. SJS/TEN induced by certain drug is well known to be associated with some human leukocyte antigen (HLA) gene type. We aimed to explore HLA allele frequencies and their association with SJS/TEN according to culprit drugs in Korea. Read More

    [DRUG INDUCED EXANTHEMA AND SEVERE CUTANEOUS DRUG REACTIONS].
    Rev Prat 2015 Sep;65(7):981-5
    Cutaneous adverse drug reactions (CADR) are delayed hypersensivities. Their clinical presentation and severity are very diverse ranging from the frequent and benign exanthemas to the rare but severe CADR involving deep organs in the case of drug reaction with eosinophilia and systemic symptoms (DRESS) or leading to skin bulla and epidermal detachment in toxic epidermal necrolysis. The main differential diagnoses are infections, especially viral ones, which could give clinical symptoms identical to those occurring in CADR. Read More

    Stevens-Johnson syndrome and toxic epidermal necrolysis: an update on pharmacogenetics studies in drug-induced severe skin reaction.
    Pharmacogenomics 2015 Nov 10;16(17):1989-2002. Epub 2015 Nov 10.
    Department of Biomedicine & Prevention, Genetics Unit, University of Rome "Tor Vergata", Italy.
    Stevens-Johnson syndrome and toxic epidermal necrolysis are severe, life-threatening drug reactions involving skin and membranes mucous, which are associated with significant morbidity and mortality and triggered, especially by drug exposure. Different studies have demonstrated that drug response is a multifactorial character and that the interindividual variability in this response depends on both environmental and genetic factors. The last ones have a relevant significance. Read More

    Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis--A Comprehensive Review and Guide to Therapy. I. Systemic Disease.
    Ocul Surf 2016 Jan 5;14(1):2-19. Epub 2015 Nov 5.
    Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA. Electronic address:
    The intent of this review is to comprehensively appraise the state of the art with regard to Stevens Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN), with particular attention to the ocular surface complications and their management. SJS and TEN represent two ends of a spectrum of immune-mediated, dermatobullous disease, characterized in the acute phase by a febrile illness followed by skin and mucous membrane necrosis and detachment. The widespread keratinocyte death seen in SJS/TEN is rapid and irreversible, and even with early and aggressive intervention, morbidity is severe and mortality not uncommon. Read More

    Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis: An Update.
    Am J Clin Dermatol 2015 Dec;16(6):475-93
    Division of Dermatology, Department of Medicine, Sunnybrook Health Sciences Centre, 2075 Bayview Avenue, Room M1-737, Toronto, ON, M4N 3M5, Canada.
    Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are life-threatening mucocutaneous reactions, predominantly drug induced. The mortality rates for SJS and TEN are as high as 30 %, and short- and long-term morbidities are very common. SJS/TEN is one of the few dermatological diseases that constitute a true medical emergency. Read More

    Drug-induced liver injury associated with Stevens-Johnson syndrome/toxic epidermal necrolysis: Patient characteristics, causes, and outcome in 36 cases.
    Hepatology 2016 Mar 26;63(3):993-9. Epub 2015 Nov 26.
    Department of Gastroenterology, St. John's Medical College Hospital, Bangalore, India.
    Unlabelled: The liver and skin are the organs most commonly involved in serious adverse drug reactions. Rarely a drug reaction can affect both organs concurrently. The association of drug-induced liver injury (DILI) and Stevens-Johnson syndrome (SJS) or toxic epidermal necrosis (TEN) is even rarer and not well studied. Read More

    A Case of Toxic Epidermal Necrolysis Secondary to Acetaminophen in a Child.
    Curr Drug Saf 2016 ;11(1):99-101
    Clinical Pharmacology- Hospital General Universitario de Alicante, Pintor de Baeza, 12-03010-Edificio Gris- 3ª planta-Alicante (Alicante), Spain.
    Objective: To report and discuss a serious cutaneous adverse reaction in a child who was treated with acetaminophen (paracetamol).

    Case Summary: A five years old male child presented a pruriginous maculopapular rash and a "drug-induced Stevens-Johnson syndrome/Toxic Epidermal Necrolysis" was suspected. Applying Spanish Pharmacovigilance System probability algorithm (modified Karch-Lasagna algorithm) for the suspected drugs (acetaminophen, ibuprofen and azithromycin), the causality of this adverse reaction was possible for acetaminophen and unlikely for the other two drugs. Read More

    Genetic screening for human leukocyte antigen alleles prior to carbamazepine treatment.
    J Clin Neurosci 2015 Dec 28;22(12):1992-3. Epub 2015 Aug 28.
    Department of Neurology, St George Hospital Sydney, Kogarah, NSW, Australia; University of New South Wales, High Street, Kensington, NSW 2052, Australia.
    We describe a 28-year-old Malaysian Australian man of Han Chinese descent with toxic epidermal necrolysis (TEN), occurring 2 weeks after commencing carbamazepine. He was subsequently found to be positive for human leukocyte antigen (HLA)-B*1502. Carbamazepine-induced Stevens-Johnson syndrome/TEN is strongly associated with the HLA-B*1502 allele, which is highly prevalent in Han Chinese, Malay, Thai and Indian populations. Read More

    Dapsone in the treatment of pemphigus vulgaris: adverse effects and its importance as a corticosteroid sparing agent.
    An Bras Dermatol 2015 May-Jun;90(3 Suppl 1):51-4
    Instituto de Dermatologia Professor Rubem David Azulay, Santa Casa da Misericórdia do Rio de Janeiro, Rio de Janeiro, RJ, BR.
    Pemphigus vulgaris is an autoimmune disease characterized by suprabasal blisters with acantholysis, which has a fatal course in a large number of untreated patients. Systemic corticosteroid therapy is considered first-line therapy. Adjuvant treatment with the goal of sparing corticosteroids include, among others, dapsone. Read More

    Paraquat Poisoning Followed by Toxic Epidermal Necrolysis: A Report of Two Cases and Published Work Review.
    Dermatology 2015 24;231(3):209-12. Epub 2015 Jul 24.
    Department of Nephrology and Rheumatology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, PR China.
    Toxic epidermal necrolysis (TEN) is a life-threatening, typically drug-induced, mucocutaneous disease. Whether paraquat, one of the most widely used herbicides, could induce TEN is not known. We describe 2 paraquat-poisoned patients with TEN. Read More

    Monitoring the acute response in severe hypersensitivity reactions to drugs.
    Curr Opin Allergy Clin Immunol 2015 Aug;15(4):294-9
    aDepartment of Dermatology bDivision of Flow Cytometry, Kyorin University School of Medicine, Tokyo cDepartment of Dermatology, Kawasaki Hospital, Kawasaki Medical School, Okayama, Japan.
    Purpose Of Review: Severe adverse drug reactions (ADRs) including Stevens-Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN) and drug-induced hypersensitivity syndrome (DiHS)/drug reaction with eosinophilia and systemic symptoms (DRESS) are acute life-threatening conditions. There is the urgent need for reliable, noninvasive and standardized laboratory tests for identifying patients at higher risk of developing severe ADRs.

    Recent Findings: Although previous studies demonstrated the pathogenic role of TNF-α, IFN-γ, IL-10, perforin/granzyme B, Fas L and granulysin in the development of severe ADRs, there have been no biomarkers predicting progression to severe ADRs. Read More

    Severe delayed skin reactions related to drugs in the paediatric age group: A review of the subject by way of three cases (Stevens-Johnson syndrome, toxic epidermal necrolysis and DRESS).
    Allergol Immunopathol (Madr) 2016 Jan-Feb;44(1):83-95. Epub 2015 Jun 15.
    Servicio de Alergia, Hospital Universitario La Paz, IdiPaz, Madrid, Spain.
    Severe delayed drug-induced skin reactions in children are not common but potentially serious. This article describes aspects concerning the etiology, pathogenesis and clinical manifestations of these processes; it presents three paediatric cases, namely STS (Steven Johnson Syndrome), TEN (toxic epidermal necrolysis), probably related to amoxicillin/clavulanate and ibuprofen and DRESS (a drug reaction with eosinophilia and systemic symptoms) secondary to phenytoin; and in relation to them, the diagnosis and the treatment of these processes are discussed and reviewed. The AGEP (acute generalised exanthematous pustulosis) is also reviewed. Read More

    Erythema multiforme--etiopathogenic, clinical and therapeutic aspects.
    Rev Med Chir Soc Med Nat Iasi 2015 Jan-Mar;119(1):55-61
    Aim: To present the epidemiological, etiopathogenic, clinical and therapeutic aspects in Erythema multiforme (EM).

    Material And Methods: This is a 3-year retrospective study based on medical records of patients with EM admitted to the Dermatology Clinic. Forty patients were included in this study. Read More

    Dialysis-associated pseudoporphyria successfully treated with vitamin D. Report of two cases.
    G Ital Dermatol Venereol 2015 Jun;150(3):327-9
    Unit of Dermatology, NESMOS Department, Faculty of Medicine, Sant'Andrea" Hospital "Sapienza" University, Rome, Italy -
    Pseudoporphyria refers to a rare bullous dermatosis characterized by the clinical and histological features of porfiria cutanea tarda without abnormalities in porphyrin metabolism. The pathogenesis is heterogeneous and several exogenous factors may promote the bullous lesion formation, including medications, end stage renal disease, dialysis and tanning beds. Regarding treatment of this condition, in literature different therapy have been reported, such as glutathione and his precursor N-acetylcysteine, which presents anti-oxidant properties; however even more toxic drugs, such as chloroquine, are used. Read More

    Data Mining FAERS to Analyze Molecular Targets of Drugs Highly Associated with Stevens-Johnson Syndrome.
    J Med Toxicol 2015 Jun;11(2):265-73
    Medical Informatics Team, Office of Clinical Pharmacology, Office of Translational Science, Division of Applied Regulatory Science, Center for Drug Evaluation and Research, Food and Drug Administration, Bldg 64, Rm 2012, 10903 New Hampshire Ave, Silver Spring, MD, 20993, USA,
    Drug features that are associated with Stevens-Johnson syndrome (SJS) have not been fully characterized. A molecular target analysis of the drugs associated with SJS in the FDA Adverse Event Reporting System (FAERS) may contribute to mechanistic insights into SJS pathophysiology. The publicly available version of FAERS was analyzed to identify disproportionality among the molecular targets, metabolizing enzymes, and transporters for drugs associated with SJS. Read More

    Role of dermatology in pharmacogenomics: drug-induced skin injury.
    Pharmacogenomics 2015 ;16(4):401-12
    Different individuals may respond diversely to the same drug, in terms of efficacy and toxicity. Adverse drug reactions cause about 6% of all hospital admissions and account for up to 9% of hospitalization costs. Drug-induced skin injury (DISI) is the most common presentation of adverse drug reactions, ranging from maculopapular eruptions to severe adverse cutaneous drug reactions (SCARs) with mortality of up to 40%. Read More

    [A case of antitubercular drug-induced toxic epidermal necrosis in a systemic lupus erythematosus patient during treatment for pulmonary tuberculosis].
    Kekkaku 2014 Nov;89(11):807-12
    A 48-year-old woman, who had been suffering from systemic lupus erythematosus for one year and receiving steroid therapy, was admitted to our hospital because of pulmonary tuberculosis. The tuberculosis was treated with INH, RFP, EB, and PZA after having doubled the dose of steroid, but terminated three weeks later due to the appearance of erythema exsudativum multiforme. Treatment was resumed with PZA, SM, and LVFX after resolution of the eruption. Read More

    Mycoplasma pneumoniae-induced rash and mucositis as a syndrome distinct from Stevens-Johnson syndrome and erythema multiforme: a systematic review.
    J Am Acad Dermatol 2015 Feb;72(2):239-45
    Department of Dermatology, University of California, San Francisco, California. Electronic address:
    Background: Mycoplasma pneumoniae infection is associated with extrapulmonary complications, including mucocutaneous eruptions. These eruptions, which have been termed either "Stevens-Johnson syndrome" or "erythema multiforme" in the literature, may differ from drug-induced Stevens-Johnson syndrome or viral-associated erythema multiforme.

    Objective: We sought to review the literature characterizing morphology and disease course of M pneumoniae-associated mucocutaneous disease. Read More

    Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS/TEN): could retinoids play a causative role?
    Med Sci Monit 2015 Jan 12;21:133-43. Epub 2015 Jan 12.
    Department of Pediatrics, University of Mississippi Medical Center, Jackson, MS, USA.
    Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS/TEN) are overlapping manifestations on a spectrum of acute drug-induced conditions associated with severe blistering, skin peeling, and multi-organ damage. TEN is an eruption resembling severe scalding, with ≥30% skin detachment. SJS is a mild form of TEN, characterized histologically by epidermal keratinocyte apoptosis with dermo-epidermal separation and extensive small blisters with <10% body surface skin detachment. Read More


    [Allopurinol hypersensitivity syndrome: Liver transplantation after treatment of asymptomatic hyperuricaemia].
    Dtsch Med Wochenschr 2014 Dec 25;139(49):2537-40. Epub 2014 Nov 25.
    Rechtsanwalt, Berlin.
    Admission Findings: A 41 year old patient started treatment with 300 mg/d allopurinol for asymptomatic hyperuricaemia (9,2 mg/dl).

    Course: 4 weeks later he developed exfoliative skin lesions with haemorrhage, fever, eosinophilia and acute liver and renal failure, typical for an allopurinol hypersensitivity syndrome (AHS).An orthotopic liver-transplantation was performed. Read More

    Purpura Fulminans in Toxic Epidermal Necrolysis: Case Report and Review.
    J Burn Care Res 2015 Nov-Dec;36(6):e274-82
    From the *Department of Medicine, †Nathan Speare Regional Burn Treatment Center, and ‡Department of Pathology, Crozer Chester Medical Center, Upland, Pennsylvania.
    Purpura fulminans (PF) and toxic epidermal necrolysis (TEN) are rare and life-threatening diseases. TEN is a notorious epidermolytic condition, most cases of which are drug induced. TEN is a more severe variant of epidermal necrolysis than Stevens-Johnson syndrome, as it affects a greater percentage of skin surface area. Read More

    Toxic epidermal necrolysis in a patient receiving concurrent phenytoin and whole brain and thoracic radiotherapy.
    Saudi Med J 2014 Nov;35(11):1393-5
    Department of Radiation Oncology, All India Institute of Medical Sciences, New Delhi 110029, India. Tel. +91 (112) 9575241. E-mail.
    Toxic epidermal necrolysis (TEN) is a severe drug induced type IV hypersensitivity syndrome that can be caused by anticonvulsant drugs, especially the aromatic anticonvulsants such as phenytoin. Most patients with brain metastasis receive whole brain radiotherapy along with anti-edema measures and anticonvulsants either as prophylactic or for symptom control; phenytoin being the most commonly used drug. In a subset of patients, cranial irradiation may act as a precipitating factor along with anticonvulsants for the development of TEN. Read More

    SJS/TEN overlap associated with lomefloxacin: case report and molecular typing studies.
    Dermatology 2014 25;229(4):319-23. Epub 2014 Oct 25.
    Pavia Poison Control Centre and National Toxicology Information Centre, IRCCS Maugeri Foundation Clinical Institute and University of Pavia, Italy.
    Background: Stevens-Johnson syndrome (SJS) or toxic epidermal necrolysis (TEN) may develop in susceptible patients after administration of different drugs. Only mild cutaneous reactions have been related to lomefloxacin. A correlation between human leucocyte antigen (HLA) and cutaneous adverse reaction has been identified. Read More

    Clinical application of pharmacogenomics: the example of HLA-based drug-induced toxicity.
    Public Health Genomics 2014 21;17(5-6):248-55. Epub 2014 Oct 21.
    Laboratory for International Alliance on Genomic Research, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
    Pharmacogenomics is gradually becoming more and more indispensable in modern medicine. In several cases, a pharmacogenomics test may alleviate serious drug-induced adverse reactions, if it precedes drug prescription. In this article, we provide an overview of the well-established HLA-based carbamazepine- and allopurinol-induced adverse reactions, as one of the most characteristic examples of the clinical application of pharmacogenomics, highlighting its regional impact in Southeast Asian populations in preventing adverse reactions of certain drug/allele pairs. Read More

    Clinical features of and genetic predisposition to drug-induced Stevens-Johnson syndrome and toxic epidermal necrolysis in a single Korean tertiary institution patients-investigating the relation between the HLA -B*4403 allele and lamotrigine.
    Eur J Clin Pharmacol 2015 Jan 21;71(1):35-41. Epub 2014 Oct 21.
    Division of Allergy and Immunology, Department of Internal Medicine, Institute of Allergy, Yonsei University College of Medicine, Seoul, South Korea.
    Purpose: Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare but fatal adverse mucocutaneous reactions to certain drugs. Recent studies suggest that ethnicity and genetic predisposition may play a crucial role in the manifestation of the reaction. In this study, we described the role of human leukocyte antigen (HLA)-B alleles in the development of clinical characteristics and treatment outcomes of SJS/TEN in a single Korean tertiary hospital. Read More

    Drug-induced linear IgA bullous dermatosis simulating toxic epidermal necrolysis.
    J Med Liban 2014 Jul-Sep;62(3):176-9
    Linear IgA bullous dermatosis (LAD) is an autoimmune subepidermal blistering disorder. LAD may be either idiopathic or drug related; the most common drug being vancomycin. The clinical presentations of both idiopathic and drug-related LAD are variable and may mimic other blistering disorders. Read More

    Bullous pemphigoid induced by m-TOR inhibitors in renal transplant recipients.
    J Eur Acad Dermatol Venereol 2015 Aug 29;29(8):1626-30. Epub 2014 Aug 29.
    Department of Dermatology, AOU of Cagliari, Cagliari, Italy.
    Background: Bullous pemphigoid (BP) is an acquired autoimmune disease, with typical histology and immune pathological findings, which might be associated with drug therapy. The list of responsible drugs increases every year, but a current literature revision do not include the mammalian target of rapamycin (mTOR) inhibitors. By converse, bullous pemghigoid cases have been described in renal transplant recipients and associated with the allogenic graft itself, causing a cross reaction against the skin, or unbalancing the immune response, through a chronic cell-mediated suppression, non-specifically favouring the autoantibody production. Read More

    Paracetamol-induced Stevens Johnson syndrome and cholestatic hepatitis.
    Curr Drug Saf 2015 ;10(2):187-9
    Departement de Pharmacologie Clinique, Faculte de Medecine de Sousse, Avenue Mohamed Karoui, 4002 Sousse, B.P.: 126, Tunisia.
    Stevens-Johnson syndrome (SJS) is an uncommon life-threatening skin disease, generally induced by drugs. Extracutaneous manifestations of the syndrome can occur, and may involve the conjunctiva, buccal mucosa, gastrointestinal and genitourinary tracts. Cholestatic hepatitis has been rarely described in SJS. Read More

    Drug-induced acute pancreatitis: a rare manifestation of an incomplete "dapsone syndrome".
    Indian J Pharmacol 2014 Jul-Aug;46(4):455-7
    Department of Medicine, Assam Medical College, Dibrugarh, Assam, India.
    Drug-induced acute pancreatitis (AP) is under-reported, and a large number of drugs are listed as offenders, but are often overlooked. Knowledge about the possible association of medications in causing AP is important, and needs a high index of suspicion, especially with drugs that have been reported to be the etiology only rarely. Dapsone, a commonly used drug, can cause various hypersensitivity reactions including AP collectively called "dapsone syndrome. Read More

    Erythema multiforme, Stevens-Johnson syndrome and toxic epidermal necrolysis: a comparative review.
    Vet Dermatol 2014 Oct 3;25(5):406-e64. Epub 2014 Jul 3.
    Department of Pathobiology, University of Guelph, Guelph, Ontario, Canada, N1G2W1.
    Background: Human erythema multiforme (EM) and Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) are separate conditions. There is no consensus on classification criteria for the eponymous diseases in animals.

    Results: Animal EM is very different from 90% of human EM, which is herpes virus associated (HAEM). Read More

    [Adverse effects of antiepileptic drugs].
    Nihon Rinsho 2014 May;72(5):908-19
    Adverse effects of antiepileptic drugs are classified into idiosyncratic adverse effects, pharmacology-related adverse effects and biological effect after modification of seizure frequencies. Pharmacology-related adverse effects include those by administered AED and those by mutual interactions. Stevens-Johnson syndrome, one of the idiosyncratic adverse effects, may be predicted by the intrinsic HLA type (e. Read More

    The study of severe cutaneous drug hypersensitivity reactions from a systems biology perspective.
    Curr Opin Allergy Clin Immunol 2014 Aug;14(4):301-6
    aResearch Laboratory, IBIMA, Regional University Hospital of Malaga, UMA bAllergy Unit, IBIMA, Regional University Hospital of Malaga, UMA cDepartment of Molecular Biology and Biochemistry, Faculty of Sciences, University of Malaga dCIBER de Enfermedades raras (CIBERER), Malaga, Spain.
    Purpose Of Review: Stevens-Johnson syndrome and toxic epidermal necrolysis are severe hypersensitivity reactions, the majority of which are drug induced. The underlying mechanisms are not fully understood. Here, we review recent findings concerning both mechanistic and genetic factors related to these diseases and propose future approaches to unravel their complexity. Read More

    The serum level of HMGB1 (high mobility group box 1 protein) is preferentially high in drug-induced hypersensitivity syndrome/drug reaction with eosinophilia and systemic symptoms.
    Br J Dermatol 2014 Dec 27;171(6):1585-8. Epub 2014 Oct 27.
    Department of Environmental Immuno-Dermatology, Yokohama City University Graduate School of Medicine, Yokohama, Japan.

    HLA associations and clinical implications in T-cell mediated drug hypersensitivity reactions: an updated review.
    J Immunol Res 2014 8;2014:565320. Epub 2014 May 8.
    Department of Dermatology, Drug Hypersensitivity Clinical and Research Center, Chang Gung Memorial Hospitals, Linkou 33305, Taiwan ; College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan ; Department of Dermatology, Keelung Chang Gung Memorial Hospital, No. 222 Maijin Road, Anle District, Keelung City 20448, Taiwan.
    T-cell mediated drug hypersensitivity reactions may range from mild rash to severe fatal reactions. Among them, drug reaction with eosinophilia and systemic symptoms (DRESS) or drug-induced hypersensitivity syndrome (DIHS), Stevens-Johnson syndrome/ toxic epidermal necrolysis (SJS/TEN), are some of the most life-threatening severe cutaneous adverse reactions (SCARs). Recent advances in pharmacogenetic studies show strong genetic associations between human leukocyte antigen (HLA) alleles and susceptibility to drug hypersensitivity. Read More

    Bullous pemphigoid induced by vildagliptin: a report of three cases.
    Fundam Clin Pharmacol 2015 Feb 9;29(1):112-4. Epub 2014 Jun 9.
    Département de Pharmacologie, Faculté de Médecine, Centre Régional de PharmacoVigilance, Centre Hospitalier Universitaire de Lille, Université de Lille 2, 1, place de Verdun, 59037, Lille, France.
    To report three cases of bullous pemphigoid in patients treated with vildagliptin. Case 1: An 86-year-old woman presented with bullous pemphigoid after 1 month of treatment with vildagliptin and metformin. After introduction of clobetasol, the symptoms resolved although vildagliptin was continued. Read More

    [Severe drug-induced skin reactions. Stevens-Johnson syndrome and toxic epidermal necrolysis].
    Hautarzt 2014 May;65(5):415-23
    Dokumentationszentrum schwerer Hautreaktionen (dZh), Klinik für Dermatologie und Venerologie, Universitätsklinikum Freiburg, Hauptstr. 7, 79104, Freiburg, Deutschland,
    Stevens-Johnson syndrome (SJS) and Toxic epidermal necrolysis (TEN) are characterized by extensive blistering of the skin and mucosa; they are considered as one disease entity with varying severity. They are rare but potentially life-threatening and accompanied by high mortality. A clear clinical diagnosis is needed to direct specific therapy, but supportive therapy remains most important. Read More

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