5,477,656 results match your criteria Drug safety : an international journal of medical toxicology and drug experience[Journal]

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Late avulsion of a free flap in a patient with severe psychiatric illness: Establishing a successful salvage strategy.

Arch Plast Surg 2019 Apr 20. Epub 2019 Apr 20.

Department of Plastic, Reconstructive and Hand Surgery, University Hospital of Lausanne (CHUV), Lausanne, Switzerland.

Post-traumatic defects of the distal third of the leg often require skipping a few steps of the well-established reconstructive ladder, due to the limited local reliable reconstructive options. In rare cases, the reconstructive plan and flap choice may encounter challenges when the patient has psychiatric illness affecting compliance with postoperative care. We describe a case of a patient with severe intellectual disability and an open fracture of the distal lower limb. Read More

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http://dx.doi.org/10.5999/aps.2018.01039DOI Listing

Disseminated Trichosporon asahii infection in a combined liver-kidney transplant recipient successfully treated with voriconazole.

Immun Inflamm Dis 2019 Apr 20. Epub 2019 Apr 20.

Department of Infectious Disease, Medanta The Medicity, Gurgaon, Haryana, India.

Introduction: Trichosporon asahii is an emerging cause of systemic fungal infection in an immunocompromised host. Several life threatening disseminated T. asahii infection in single solid organ (liver or kidney) transplant recipients, in neutropenic and hematological malignancy patients have been reported. Read More

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http://dx.doi.org/10.1002/iid3.250DOI Listing

Blueberry juice protects osteocytes and bone precursor cells against oxidative stress partly through SIRT1.

FEBS Open Bio 2019 Apr 1. Epub 2019 Apr 1.

Department of Biomedical Experimental and Clinical Sciences 'Mario Serio', University of Florence, Italy.

Oxidative stress and abnormal osteocyte apoptosis are often related to dysregulation of bone turnover and chronic bone loss, and so fruit and vegetables with high antioxidant potential may play an important role in the prevention and/or management of osteoporosis. Osteocytes are the main regulators of bone remodelling. For the first time, we demonstrate here that blueberry juice (BJ), obtained from Vaccinium myrtillus, rich in polyphenols, shows antioxidant and antiosteoclastogenic properties in MLO-Y4 osteocytes. Read More

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http://dx.doi.org/10.1002/2211-5463.12634DOI Listing

Artificial Intelligence (AI) and Pharmacometrics: Time to Embrace, Capitalize and Advance?

CPT Pharmacometrics Syst Pharmacol 2019 Apr 21. Epub 2019 Apr 21.

Clinical Pharmacology, GlaxoSmithKline, Collegeville, PA.

Artificial intelligence (AI) has been described as the machine for the fourth industrial revolution. Without exception, AI is predicted to change the face of every industry. In the field of drug development, AI is employed to enhance efficiency. Read More

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http://dx.doi.org/10.1002/psp4.12418DOI Listing

Hydrochlorothiazide-Induced Photosensitivity in a Psoriasis Patient Following Exposure to Narrow-Band UVB Excimer Therapy.

Photodermatol Photoimmunol Photomed 2019 Apr 21. Epub 2019 Apr 21.

Research Department, Moy-Fincher-Chipps Facial Plastics & Dermatology, 421 N. Rodeo Dr. #T-7, Beverly Hills, CA, 90210.

Drug-induced photosensitivity develops when use of oral or topical photosensitizing medications creates a rash after exposure to ultraviolet radiation. Medications most commonly implicated in photosensitive-drug reactions include amiodarone, nonsteroidal anti-inflammatories, thiazides, tetracycline antibiotics, chlorpromazine, and fluoroquinolones. It is generally believed that drug-induced photosensitivity is an ultraviolet A phenomenon, caused by ultraviolet wavelengths between 315 and 400 nanometers. Read More

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http://dx.doi.org/10.1111/phpp.12471DOI Listing

ABCA1 variants rs2230806 (R219K), rs4149313 (M8831I), and rs9282541 (R230C) are associated with susceptibility to coronary heart disease.

J Clin Lab Anal 2019 Apr 20:e22896. Epub 2019 Apr 20.

Department of Cardiovascular Disease, Changzhou No. 2 People's Hospital, Affiliated Nanjing Medical University, Changzhou, China.

Background: To investigate the association between three single nucleotide polymorphisms (SNPs) of ABCA1 gene and susceptibility to coronary heart disease (CHD) in Chinese Han population.

Methods: A total of 484 CHD patients and 488 controls were included in the study. Three SNPs rs2230806 (R219K), rs4149313 (M8831I), and rs9282541 (R230C) in ABCA1 gene were genotyped by SNaPshot. Read More

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http://dx.doi.org/10.1002/jcla.22896DOI Listing

MF59 adjuvant enhances the immunogenicity and protective immunity of the OmpK/Omp22 fusion protein from Acineterbacter baumannii through intratracheal inoculation in mice.

Scand J Immunol 2019 Apr 21:e12769. Epub 2019 Apr 21.

Institute of Immunology and Molecular Biology, North Sichuan Medical College, Nanchong, 637000, People's Republic of China.

Acinetobacter baumannii (A. baumannii) is an emerging nosocomial pathogenic bacterium which leads to hospital infections. The increase of drug-resistant A. Read More

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http://dx.doi.org/10.1111/sji.12769DOI Listing

Age-Dependency of Levetiracetam Effects on Exocytotic GABA Release from Nerve Terminals in the Hippocampus and Cortex in Norm and After Perinatal Hypoxia.

Cell Mol Neurobiol 2019 Apr 20. Epub 2019 Apr 20.

The Department of Neurochemistry, Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, 9 Leontovicha Str, Kiev, 01030, Ukraine.

Perinatal hypoxia can lead to multiple chronic neurological deficits, e.g., mental retardation, behavioral abnormalities, and epilepsy. Read More

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http://dx.doi.org/10.1007/s10571-019-00676-6DOI Listing
April 2019
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Pharmacovigilance Systems in Arab Countries: Overview of 22 Arab Countries.

Drug Saf 2019 Apr 20. Epub 2019 Apr 20.

College of Pharmacy, Department of Clinical Pharmacy, University of Hail, P.O. Box 6166, Hail, 81442, Saudi Arabia.

Pharmacovigilance has received much attention in Arab countries recently due to the development of new regulations. However, there are differences in the progression of pharmacovigilance systems by regulatory agencies in these countries because only some are able to meet the requirements for conducting pharmacovigilance activities. Only 45% of Arab countries are official members of the World Health Organization (WHO) Collaborating Centre for International Drug Monitoring. Read More

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http://link.springer.com/10.1007/s40264-019-00807-4
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http://dx.doi.org/10.1007/s40264-019-00807-4DOI Listing
April 2019
3 Reads

Timely and large dose of clotting factor IX provides better joint wound healing after hemarthrosis in hemophilia B mice.

Int J Hematol 2019 Apr 20. Epub 2019 Apr 20.

Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai, China.

Bleeding into the joints represents the major morbidity of severe hemophilia and predisposes it to hemophilic arthropathy (HA). In a reproducible hemarthrosis mouse model, we found distinct changes in thrombin activity in joint tissue homogenate following exposure of the joint to blood in wide type (WT) and hemophilic B mice. Specifically, at early time points (4 h and 24 h) after hemarthrosis, thrombin activity in WT mice quickly peaked at 4 h, and returned to baseline after 1 week. Read More

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http://link.springer.com/10.1007/s12185-019-02639-5
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http://dx.doi.org/10.1007/s12185-019-02639-5DOI Listing
April 2019
1 Read

A Genome-Wide Association Study of Bisphosphonate-Associated Atypical Femoral Fracture.

Calcif Tissue Int 2019 Apr 20. Epub 2019 Apr 20.

Department of Medical Sciences, Uppsala University, Uppsala, Sweden.

Atypical femoral fracture is a well-documented adverse reaction to bisphosphonates. It is strongly related to duration of bisphosphonate use, and the risk declines rapidly after drug withdrawal. The mechanism behind bisphosphonate-associated atypical femoral fracture is unclear, but a genetic predisposition has been suggested. Read More

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http://dx.doi.org/10.1007/s00223-019-00546-9DOI Listing

Immune Activation and Microbial Translocation Markers in HIV-Exposed Uninfected Malawian Infants in the First Year of Life.

J Trop Pediatr 2019 Apr 21. Epub 2019 Apr 21.

National Center for Global Health, Istituto Superiore di Sanità, Rome 00161, Italy.

Background: HIV-exposed uninfected (HEU) infants show a high rate of morbidity. We aimed to investigate on biomarkers of immune activation/microbial translocation in HEU infants, evaluating the impact that infections/malnutrition can have on biomarker levels during the first year of life.

Methods: Clinical data of 72 Malawian infants were recorded monthly and correlated with levels of soluble CD14 (sCD14), lipopolysaccharide-binding protein (LBP) and intestinal fatty acid-binding protein (I-FABP), analyzed longitudinally. Read More

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https://academic.oup.com/tropej/advance-article/doi/10.1093/
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http://dx.doi.org/10.1093/tropej/fmz022DOI Listing
April 2019
1 Read

Prediction of the effect of dapagliflozin on kidney and heart failure outcomes based on short-term changes in multiple risk markers.

Nephrol Dial Transplant 2019 Apr 21. Epub 2019 Apr 21.

Department of Clinical Pharmacy and Pharmacology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

Background: Besides improving glucose control, sodium-glucose co-transporter 2 inhibition with dapagliflozin reduces blood pressure, body weight and urinary albumin:creatinine ratio (UACR) in patients with type 2 diabetes (T2DM). The parameter response efficacy (PRE) score was developed to predict how short-term drug effects on cardiovascular risk markers translate into long-term changes in clinical outcomes. We applied the PRE score to clinical trials of dapagliflozin to model the effect of the drug on kidney and heart failure (HF) outcomes in patients with T2DM and impaired kidney function. Read More

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http://dx.doi.org/10.1093/ndt/gfz064DOI Listing

Antiproliferative Effects of Matricine in Gemcitabine-Resistant Human Pancreatic Carcinoma Cells Are Mediated via Mitochondrial-Mediated Apoptosis, Inhibition of Cell Migration, Invasion Suppression, and Mammalian Target of Rapamycin (mTOR)-TOR/PI3K/AKT Signalling Pathway.

Med Sci Monit 2019 Apr 21;25:2943-2949. Epub 2019 Apr 21.

Department of Emergency Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (mainland).

BACKGROUND Pancreatic cancer is a major cause of mortality worldwide. Inefficient drugs, their adverse effects, and the development of drug resistance make it difficult to curb the growing incidence of pancreatic cancer. Against this backdrop, the development new drug regimens with no or negligible adverse effects is imperative. Read More

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https://www.medscimonit.com/abstract/index/idArt/914244
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http://dx.doi.org/10.12659/MSM.914244DOI Listing
April 2019
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Cooperative impact of thiazolidinedione and fatty acid synthase on human osteogenesis.

Aging (Albany NY) 2019 Apr 20. Epub 2019 Apr 20.

Inflammation Research and Drug Development Center, Taiwan, Republic of China.

Previous, we found that the small molecules capable of inhibiting the expression and the pro-adipogenic activity of ZNF521 might improve the osteogenic performance of aging human bone marrow MSCs (bmMSCs), and that fatty acid synthase (FASN) was a critical effector of ZNF521's pro-adipogenic activity. Here, by characterizing the netoglitazone (MCC-555), one of the thiazolidinediones known as adipogenic enhancers, as an inhibitor of ZNF521 expression, we found that MCC-555 indeed also harbored pro-osteoblastic effect. Investigation revealed that MCC-555 might function as a GSK3β inhibitor to promote osteoblastogenesis and bone formation. Read More

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http://dx.doi.org/10.18632/aging.101916DOI Listing

Effect of metformin on the size of the HIV reservoir in non-diabetic ART-treated individuals: single-arm non-randomised Lilac pilot study protocol.

BMJ Open 2019 Apr 20;9(4):e028444. Epub 2019 Apr 20.

The Ottawa Hospital, University of Ottawa, Ottawa, Ontario, Canada.

Introduction: People living with HIV (PLWH) on antiretroviral therapy (ART) do not progress to AIDS. However, they still suffer from an increased risk of inflammation-associated complications. HIV persists in long-lived CD4+ T cells, which form the major viral reservoir. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-028444DOI Listing

Oral anticoagulation therapy use in patients with atrial fibrillation after the introduction of non-vitamin K antagonist oral anticoagulants: findings from the French healthcare databases, 2011-2016.

BMJ Open 2019 Apr 20;9(4):e026645. Epub 2019 Apr 20.

University of Bordeaux, Inserm, Bordeaux Population Health Research Center, Team Pharmacoepidemiology - UMR 1219, Bordeaux, France.

Objectives: To describe (i) the trend in oral anticoagulant (OAC) use following the introduction of non-vitamin K antagonist oral anticoagulant (NOAC) therapy for stroke prevention in atrial fibrillation (AF) patients and (ii) the current patterns of use of NOAC therapy in new users with AF in France.

Design: (i) Repeated cross-sectional study and (ii) population-based cohort study.

Setting: French national healthcare databases (50 million beneficiaries). Read More

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http://dx.doi.org/10.1136/bmjopen-2018-026645DOI Listing

Deep continuous patient-requested sedation until death: a multicentric study.

BMJ Support Palliat Care 2019 Apr 20. Epub 2019 Apr 20.

Department of Palliative Care, Hospices Civils de Lyon, Lyon, France

Objectives: In 2016, a new law was adopted in France granting patients the right, under specific conditions, to continuous deep sedation until death (CDSUD). The goal of this study was to measure the frequency of requests for CDSUD from patients in palliative care.

Methods: The data collected from the medical records of patients in palliative care units (PCU) or followed by palliative care support teams (PCST) in the Rhône-Alpes area, who died after CDSUD, focused on the patient's characteristics, the drugs used (and compliance with regulatory processes). Read More

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http://spcare.bmj.com/lookup/doi/10.1136/bmjspcare-2018-0017
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http://dx.doi.org/10.1136/bmjspcare-2018-001712DOI Listing
April 2019
1 Read

Complex encephalopathy arising from the combination of opioids and gabapentin.

BMJ Case Rep 2019 Apr 20;12(4). Epub 2019 Apr 20.

Allegiance Health, Jackson, Michigan, USA.

The interactions between opioids and gabapentin are more clinically relevant than ever. Prescriptions dispensed for gabapentin increased from 39 million in 2012 to 64 million in 2018 in the USA and are ever increasing. Authors present a challenging case of these interactions. Read More

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http://dx.doi.org/10.1136/bcr-2018-228354DOI Listing

Is ivabradine a wonder drug for atypical POTS?

BMJ Case Rep 2019 Apr 20;12(4). Epub 2019 Apr 20.

Internal Medicine, Abington Hospital - Jefferson Health, Abington, PA, USA.

Syncope is a sudden loss and gain of consciousness. Traditionally, it is caused by the abnormalities of neurological, cardiac or vasovagal systems. We present a case of a 19-year-old woman presenting with recurrent syncopal episodes with no apparent cause. Read More

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http://dx.doi.org/10.1136/bcr-2018-227789DOI Listing

Heterogeneity and emergent behaviour in the vascular endothelium.

Curr Opin Pharmacol 2019 Apr 18;45:23-32. Epub 2019 Apr 18.

Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, 161 Cathedral Street, Glasgow G4 0RE, UK.

The endothelium is the single layer of cells lining all blood vessels, and it is a remarkable cardiovascular control centre. Each endothelial cell has only a small number (on average six) of interconnected neighbours. Yet this arrangement produces a large repertoire of behaviours, capable of controlling numerous cardiovascular functions in a flexible and dynamic way. Read More

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http://dx.doi.org/10.1016/j.coph.2019.03.008DOI Listing

Protective effects of Rhizoma smilacis glabrae extracts on potassium oxonate- and monosodium urate-induced hyperuricemia and gout in mice.

Phytomedicine 2018 Nov 24;59:152772. Epub 2018 Nov 24.

Orthopedic Department, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, People's Republic of China. Electronic address:

Background: Rhizoma smilacis glabrae (RSG, tufuling) has been widely used in traditional Chinese medicine for deoxidation, dampness relief, and easing joint movement. The chemical composition of RSG has been systematically confirmed, and some of its compounds have been revealed to possess antioxidant, anti-inflammatory, immunomodulatory, hypouricemic, and hepatoprotective effects.

Purpose: We aimed to clarify whether a RSG extract attenuates hyperuricemia, paw edema, and renal injury in mice with potassium oxonate (PO)- and monosodium urate (MSU)-induced chronic hyperuricemia and gout. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09447113183058
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http://dx.doi.org/10.1016/j.phymed.2018.11.032DOI Listing
November 2018
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An integration of UPLC-DAD/ESI-Q-TOF MS, GC-MS, and PCA analysis for quality evaluation and identification of cultivars of Chrysanthemi Flos (Juhua).

Phytomedicine 2018 Dec 21;59:152803. Epub 2018 Dec 21.

School of Pharmacy, Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. Electronic address:

Background: Chrysanthemi Flos (CF), as a popular traditional Chinese medicine (TCM), has five main cultivars in China, namely "Chuju", "Boju", "Gongju", "Huaiju" and "Hangju". Due to their habitats and processing methods, great quality variations occur yet no systematical study has ever been carried out to evaluate such variations.

Purpose: In this study, we aim to establish a new approach that can serve both as a quality control method and as an identification method for cultivars of CF. Read More

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http://dx.doi.org/10.1016/j.phymed.2018.12.026DOI Listing
December 2018

DT-13 suppresses breast cancer metastasis by modulating PLOD2 in the adipocytes microenvironment.

Phytomedicine 2018 Dec 2;59:152778. Epub 2018 Dec 2.

Jiangsu Key Laboratory of Drug Screening, China Pharmaceutical University, Nanjing, China. Electronic address:

Background: Metastasis is the main cause of death in breast cancer and previous researches have indicated the pivotal role of adipocytes in breast cancer metastasis. DT-13, the saponin monomer 13 of the Dwarf lilyturf tuber, has been proved to exert potential anti-metastatic effect, the detailed mechanisms have not been well elucidated and the role of DT-13 in modulating adipocyte-breast cancer microenvironment has been given little attention.

Purpose: This study aims to explore the mechanisms of DT-13 in inhibiting breast cancer metastasis and whether DT-13 inhibit breast cancer metastasis via modulating the interactions between adipocytes and breast cancer cells. Read More

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http://dx.doi.org/10.1016/j.phymed.2018.12.001DOI Listing
December 2018

Rapid automatic identification of parameters of the Bergman Minimal Model in Sprague-Dawley rats with experimental diabetes for adaptive insulin delivery.

Comput Biol Med 2019 Apr 8;108:242-248. Epub 2019 Apr 8.

IEEE Engineering in Medicine and Biology, Mexico City, Mexico. Electronic address:

Glucose-Insulin regulation models can be used to individualize insulin therapy. However, the experimental techniques currently used to identify the appropriate parameter sets of an individual are expensive, time consuming, and very unpleasant for the patient. Since there is a wide range of intrapersonal parameter variability, the identified parameters in a laboratory setting (at rest) are not optimal for dynamic conditions of daily activities. Read More

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http://dx.doi.org/10.1016/j.compbiomed.2019.03.028DOI Listing

Teratogenic potential of third-generation antiepileptic drugs: Current status and research needs.

Pharmacol Rep 2019 Jan 31;71(3):491-502. Epub 2019 Jan 31.

Neurobiology Lab, Department of Zoology, University of Allahabad, Allahabad, India. Electronic address:

The aim of this review was to scrutinize the current literature available on teratogenic safety of third-generation antiepileptic drugs (TGAEDs) considering their clinical implications and to highlight for further research need in the interest of the diseased population in general and women with epilepsy in particular. For evaluation of the teratogenic potential of TGAEDs, this review summarized the existing information on controlled clinical trials conducted by the pharmaceutical companies, case reports, scholarly articles (prospective and retrospective studies), and experimental tests carried out so far. Firstly, clinical reports have reviewed on each drug followed by non-clinical studies reported hitherto. Read More

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http://dx.doi.org/10.1016/j.pharep.2019.01.011DOI Listing
January 2019

Recently developed synthetic compounds with anti-infective activity.

Curr Opin Pharmacol 2019 Apr 18;48:17-23. Epub 2019 Apr 18.

Centro Singular de Investigación en Química Biolóxica e Materiais Moleculares (CiQUS), Departamento de Química Orgánica, Universidade de Santiago de Compostela, calle Jenaro de la Fuente s/n, 15782 Santiago de Compostela, Spain. Electronic address:

The ability of antibiotics to cure bacterial infections is at a serious risk due to the emergence and worldwide spread of superbugs. A lack of innovation and investment for almost 50 years has led to significant efforts currently being devoted to find alternative and innovative therapies to face this challenge. This short review highlights some of the recent efforts to develop synthetic small molecules with anti-infective activity. Read More

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http://dx.doi.org/10.1016/j.coph.2019.03.004DOI Listing

Synthesis of some new C2 substituted dihydropyrimidines and their electrophysiological evaluation as L-/T-type calcium channel blockers.

Bioorg Chem 2019 Apr 11;88:102915. Epub 2019 Apr 11.

Department of Pharmaceutical Sciences, College of Pharmacy, South Dakota State University, Brookings, SD 57007, USA. Electronic address:

Drugs targeting different calcium channel subtypes have strong therapeutic potential for future drug development for cardiovascular disorders, neuropsychiatric diseases and cancer. This study aims to design and synthesize a new series of C2 substituted dihydropyrimidines to mimic the structure features of third generation long acting dihydropyridine calcium channel blockers and dihydropyrimidines analogues. The target compounds have been evaluated as blockers for Ca1. Read More

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http://dx.doi.org/10.1016/j.bioorg.2019.04.009DOI Listing

Virtual screening of active compounds from Artemisia argyi and potential targets against gastric ulcer based on Network pharmacology.

Bioorg Chem 2019 Apr 13;88:102924. Epub 2019 Apr 13.

School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, PR China; Beijing Shijitan Hospital, Capital Medical University, Beijing Key Laboratory of Bio-characteristic Profiling for Evaluation of Rational Drug Use, Beijing 100038, PR China. Electronic address:

Artemisia argyi (AA) is one of the renowned herbs in China often used in the treatment of gastric ulcer (GU). Aiming to predict the active compounds and systematically investigate the mechanisms of Artemisia argyi for GU treatment, the approach of network pharmacology, molecular docking, gene ontology (GO) analysis, and Kyoto encyclopedia of genes and genomes (KEGG) pathway enrichment analysis were adopted, respectively, in present study. A total of 13 predicted targets of the 103 compounds in Artemisia argyi were obtained. Read More

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http://dx.doi.org/10.1016/j.bioorg.2019.102924DOI Listing

An FPSE-HPLC-PDA method for rapid determination of solar UV filters in human whole blood, plasma and urine.

J Chromatogr B Analyt Technol Biomed Life Sci 2019 Apr 16;1118-1119:40-50. Epub 2019 Apr 16.

International Forensic Research Institute, Department of Chemistry and Biochemistry, Florida International University, Miami, FL, USA. Electronic address:

This paper reports a novel fabric phase sorptive extraction-high performance liquid chromatography-photodiode array detection (FPSE-HPLC-PDA) method for the simultaneous extraction and analysis of six benzophenone derivative UV filters including benzophenone (BZ); 5-benzoyl-4-hydroxy-methoxybenzenesulfonic acid (BP-4); bis(4-hydroxyphenyl)methanone (4-DHB); bis(2,4-dihydroxyphenyl)methanone (BP-2); (2,4-dihydroxybenzophenone) (BP-1) and 2,2'-dihydroxy-4-methoxybenzophenone (DHMB) in human whole blood, plasma and urine samples. Chromatographic separation method was conducted using a Spherisorb ODS 1 (C) column in isocratic elution mode with a run time <25 min. The FPSE-HPLC-PDA method was validated in the range from 0. Read More

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http://dx.doi.org/10.1016/j.jchromb.2019.04.028DOI Listing

Analysis of PK11195 concentrations in rodent whole blood and tissue samples by rapid and reproducible chromatographic method to support target-occupancy PET studies.

J Chromatogr B Analyt Technol Biomed Life Sci 2019 Apr 12;1118-1119:33-39. Epub 2019 Apr 12.

University/BHF Centre for Cardiovascular Science, University of Edinburgh, UK; Edinburgh Preclinical Imaging (EPI), University of Edinburgh, UK.

In Positron Emission Tomography (PET) research, it is important to assess not only pharmacokinetics of a radiotracer in vivo, but also of the drugs used in blocking/displacement PET studies. Typically, pharmacokinetic/pharmacodynamic (PK/PD) analyses of drugs used in rodent PET studies are based on population average pharmacokinetic profiles of the drugs due to limited blood volume withdrawal while simultaneously maintaining physiological homeostasis. This likely results in bias of PET data quantification, including unknown bias of target occupancy (TO) measurements. Read More

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http://dx.doi.org/10.1016/j.jchromb.2019.04.026DOI Listing

A new radiation force balance method for measuring diverging piston source power in the frequency range 20-100 kHz: Theory and experimental verification.

Ultrasonics 2019 Apr 3;97:11-18. Epub 2019 Apr 3.

Shanghai Institute of Ultrasound in Medicine, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, China.

The purpose of this work was to present the results of a theoretical and experimental study in which a new acoustic output power measurement method was developed for a strongly diverged ultrasonic beam (ka < 3, where k is the circular wave number and a is the radius of transducer) using acoustic radiation force. To the best of our knowledge, there is no acceptable and effective method to measure acoustic power P for diverging piston transducers from 20 kHz to 100 kHz in the range ka < 3, it is a unsolved problem acutely. In the study, we used radiation force balance (RFB) method with a novel concave semi-spherical absorbing target in far field to measure the acoustic power up to 54 W. Read More

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http://dx.doi.org/10.1016/j.ultras.2019.03.019DOI Listing

Ring and bring drug services: Delivery dealing and the social life of a drug phone.

Int J Drug Policy 2019 Apr 18;69:8-15. Epub 2019 Apr 18.

Centre for Alcohol and Drug Research, Aarhus University, Denmark. Electronic address:

Background: Illegal drug dealers no longer compete for customers only through the quality of their products, but also in convenience and speed of delivery. This article investigates "ring and bring" drug dealing, and argues that a focus on dealers' use of mobile phones is useful for exploring current changes within retail level drug markets.

Methods: The article is based on 21 face-to-face in-depth interviews with active drug dealers in Denmark all of whom were involved in the delivery of drugs (mainly cannabis and cocaine) often to buyers' homes. Read More

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http://dx.doi.org/10.1016/j.drugpo.2019.02.003DOI Listing

Simultaneous controlled release of 5-FU, DOX and PTX from chitosan/PLA/5-FU/g-C3N4-DOX/g-C3N4-PTX triaxial nanofibers for breast cancer treatment in vitro.

Colloids Surf B Biointerfaces 2019 Apr 13;179:495-504. Epub 2019 Apr 13.

Young Researchers & Elite Club, Tehran North Branch, Islamic Azad University, Tehran, Iran. Electronic address:

In the present study, the tri-layer nanofibers were synthesized via triaxial electrospinning process to control the sustained delivery of Doxorubicin (DOX), Paclitaxel (PTX) and 5- fluorouracil (5-FU) anticancer drugs from nanofibers. The 5-FU molecules were incorporated into the core solution (chitosan/polyvinyl alcohol (CS/PVA)) to fabricate the CS/PVA/5-FU inner layer of nanofibers. The intermediate layer was prepared from poly(lactic acid)/chitosan (PLA/CS) nanofibers. Read More

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http://dx.doi.org/10.1016/j.colsurfb.2019.04.026DOI Listing

Vesicle formation by ultrashort alkyl-phosphonic acids and serine in aqueous solutions.

Colloids Surf B Biointerfaces 2019 Mar 27;179:488-494. Epub 2019 Mar 27.

College of Food & Biology Engineering, Zhejiang Gongshang University, Hangzhou, Zhejiang 310035, China. Electronic address:

Vesicles possess unique biofilm structures and offer biomimetic advantages for drug and gene delivery. Herein, we report the spontaneous vesicle formation from ultrashort alkyl-phosphonic acids in the presence of amino acids. The aggregation characteristics and self-assembly structures of vesicles in aqueous solution were investigated by using dynamic light scattering, zeta potential, and cryo-transmission electron microscopy. Read More

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http://dx.doi.org/10.1016/j.colsurfb.2019.03.055DOI Listing

Mussel-inspired hybrid coating functionalized porous hydroxyapatite scaffolds for bone tissue regeneration.

Colloids Surf B Biointerfaces 2019 Apr 14;179:470-478. Epub 2019 Apr 14.

Key Lab of Advanced Technologies of Materials, Ministry of Education, School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu, Sichuan, 610031, China.

The scaffold for bone tissue engineering should possess proper porosity, adequate mechanical properties, cell affinity for cell attachment, and the capability to bind bioactive agents to induce cell differentiation. In this study, we successfully prepared a porous hydroxyapatite (HA) scaffold that is functionalized by poly(L-lysine)/polydopamine (PLL/PDA) hybrid coating. The PLL/PDA coating takes advantages of the high protein and cell affinity of PDA, as well as the biodegradability of PLL. Read More

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http://dx.doi.org/10.1016/j.colsurfb.2019.04.024DOI Listing

Facile fabrication of PEG-coated PLGA microspheres via SPG membrane emulsification for the treatment of scleroderma by ECM degrading enzymes.

Colloids Surf B Biointerfaces 2019 Apr 14;179:453-461. Epub 2019 Apr 14.

Center for Disease Biology and Integrative Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan; Department of Bioengineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan. Electronic address:

We developed a facile fabrication method for preparing poly(ethylene glycol)(PEG)-coated poly (lactic-co-glycolic acid) (PLGA) microspheres with homogeneous size distribution via a combination of mPEG-b-PLGA and Shirasu Porous Glass membrane emulsification. Subsequently, extracellular matrix (ECM) degrading enzymes, collagenase (COLase) or hyaluronidase (HAse) were loaded into the microspheres. The obtained microspheres exhibited a sustained release of COLase or HAse over 10 days. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09277765193025
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http://dx.doi.org/10.1016/j.colsurfb.2019.04.028DOI Listing
April 2019
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Preparation of letrozole dispersed pHEMA/AAm-g-LDPE drug release system: In-vitro release kinetics for the treatment of endometriosis.

Colloids Surf B Biointerfaces 2019 Apr 8;179:445-452. Epub 2019 Apr 8.

King Saud University, Advanced Manufacturing Institute, Riyadh, 11421, Saudi Arabia.

This paper focuses on the development of a drug delivery system for systemically controlled release of a poorly soluble drug, letrozole. The work meticulously describes the preparation and characterizations of 2-hydroxyethyl methacrylate (HEMA) polymerization onto hydrophilic acrylamide grafted low-density polyethylene (AAm-g-LDPE) surface for targeted drug release system. The surface morphology and thickness measurement of coated pHEMA layer were measured using scanning electron microscopy (SEM). Read More

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http://dx.doi.org/10.1016/j.colsurfb.2019.04.014DOI Listing

Draft genome sequence of Enterococcus faecium E86, a producing strain of broad- -spectrum antimicrobial peptides: description of a novel bacteriocin immunity protein and a novel MLST type.

J Glob Antimicrob Resist 2019 Apr 18. Epub 2019 Apr 18.

Departamento de Microbiologia Geral, Instituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brasil. Electronic address:

Objectives: The aim of this study is to report the draft genome sequence of the bacteriocinogenic strain Enterococcus faecium E86. Bacteriocins are prokaryotic peptides or proteins with antimicrobial activity. The genome information may then contribute to the identification of the enterocins produced by this strain that exhibits inhibitory activity against the foodborne pathogen Listeria monocytogenes and vancomycin-resistant enterococci (VRE) involved in human infections, among other bacterial genera and species. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22137165193009
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http://dx.doi.org/10.1016/j.jgar.2019.04.004DOI Listing
April 2019
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Development of sustained-release pellets to modulate the in vivo processes of the main active components of Danshen: A pharmacokinetic and pharmacodynamic evaluation.

Phytomedicine 2018 Dec 11;58:152793. Epub 2018 Dec 11.

Department of Pharmaceutics, China Pharmaceutical University, No. 24 Tongjiaxiang, Nanjing 210009, PR China. Electronic address:

Background: Danshen is a first-line traditional Chinese medicine derived from Salvia miltiorrhiza Bunge consisting mainly of tanshinone IIA, tanshinol, protocatechuic aldehyde, and salvianolic acid B, it is widely used to treat cardiovascular diseases based on the synergistic effect of its multiple active components. Recent studies have indicated that the overall effect of traditional Chinese medicine is closely related to the in vivo coexistence of a variety of active components.

Hypothesis: The prolongation of the coexistence of the four active components in Danshen in vivo by regulating their pharmacokinetic processes may contribute to better efficiency. Read More

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http://dx.doi.org/10.1016/j.phymed.2018.12.016DOI Listing
December 2018

Chikusetsu saponin IVa attenuates isoprenaline-induced myocardial fibrosis in mice through activation autophagy mediated by AMPK/mTOR/ULK1 signaling.

Phytomedicine 2018 Nov 19;58:152764. Epub 2018 Nov 19.

Medical College of China Three Gorges University, Yichang 443002, PR China; Yichang Key Laboratory of ischemic cardiovascular and cerebrovascular disease translational medicine (Three Gorges University), Yichang 443000, PR China. Electronic address:

Background: Myocardial fibrosis is a common pathological manifestation of many cardiovascular diseases at the end stage. Autophagy has been demonstrated to play a protective role in the cardiac fibrosis. Our previous studies have demonstrated that the Saponins from Panax japonicus effectively ameliorated the degree of fibrosis in rat acute myocardial ischemia injury model though the mechanisms are not clear. Read More

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http://dx.doi.org/10.1016/j.phymed.2018.11.024DOI Listing
November 2018

Quantitative determination of CBD and THC and their acid precursors in confiscated cannabis samples by HPLC-DAD.

Forensic Sci Int 2019 Apr 5;299:142-150. Epub 2019 Apr 5.

Institute of Forensic Medicine, Department of Forensic Toxicology and Chemistry, University of Bern, Bühlstrasse 20, 3012 Bern, Switzerland. Electronic address:

Analysis of cannabis has gained new importance worldwide, mainly for quality control within the legalized recreational and medical cannabis industry, but also for forensic differentiation between drug-type cannabis and legal products such as fiber hemp and CBD-rich/THC-poor cannabis. We herein present an HPLC-DAD method for quantitative analysis of major neutral and acidic cannabinoids in herbal cannabis and hashish: Δ-tetrahydrocannabinol (THC), Δ-tetrahydrocannabinolic acid A (THCA), cannabidiol (CBD), cannabidiolic acid (CBDA), and cannabinol (CBN). Plant material was dried, homogenized and extracted with a mixture of methanol/hexane. Read More

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http://dx.doi.org/10.1016/j.forsciint.2019.03.046DOI Listing

High performance liquid chromatography (HPLC) based direct and simultaneous estimation of excipients in biopharmaceutical products.

J Chromatogr B Analyt Technol Biomed Life Sci 2019 Apr 12;1117:118-126. Epub 2019 Apr 12.

Department of Chemical Engineering, Indian Institute of Technology, 110016 Hauz Khas, India. Electronic address:

Excipients are critical components of a biotherapeutic product as they have a direct impact on the product's stability and hence on its safety and efficacy. A typical biotherapeutic drug product has a variety of excipients and these need to be maintained within very tight specifications in order to ensure consistency in product quality. Hence, there is always a need for estimation of excipient concentration in the drug product. Read More

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http://dx.doi.org/10.1016/j.jchromb.2019.04.022DOI Listing

Wound dressing properties of cationized cotton fabric treated with carrageenan/cyclodextrin hydrogel loaded with honey bee propolis extract.

Int J Biol Macromol 2019 Apr 18. Epub 2019 Apr 18.

Pre-Treatment and Finishing of Cellulosic Fabric Department, Textile Research Division, National Research Center, 33 El-Behooth St, Dokki, Giza 12311, Egypt. Electronic address:

The current study was set to prepare a delivery system based on a mixture of biodegradable polymeric hydrogel (i.e., carrageenan (κ-CAR) and β-cyclodextrin (β-CD)) for encapsulating honey bee propolis extract (HBP). Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2019.04.065DOI Listing

Applications of machine learning in GPCR bioactive ligand discovery.

Curr Opin Struct Biol 2019 Apr 18;55:66-76. Epub 2019 Apr 18.

Department of Molecular Sciences, Macquarie University, Sydney, NSW 2109, Australia. Electronic address:

GPCRs constitute the largest druggable family having targets for 475 Food and Drug Administration (FDA) approved drugs. As GPCRs are of great interest to pharmaceutical industry, enormous efforts are being expended to find relevant and potent GPCR ligands as lead compounds. There are tens of millions of compounds present in different chemical databases. Read More

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http://dx.doi.org/10.1016/j.sbi.2019.03.022DOI Listing

Rewarding effects of 2-desoxypipradrol in mice.

Neurosci Lett 2019 Apr 18. Epub 2019 Apr 18.

Pharmacological Research Division, Toxicological Evaluation and Research Department, National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety, 187 Osong Saengmyeong 2-ro, Heungdeok-gu, Chungju-shi, 28159, Republic of Korea.

Desoxypipradrol (2-DPMP), a new psychoactive substance (NPS), acts as a norepinephrine-dopamine reuptake inhibitor (NDRI). NDRIs can be addictive due to their action mechanisms similar to cocaine and methamphetamine. However, there is a lack of scientific information regarding the exact dependency of 2-DPMP. Read More

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http://dx.doi.org/10.1016/j.neulet.2019.04.037DOI Listing

Effect of G-CSF on the Spatial Arrangement of CA1 Hippocampal Pyramidal Neurons after Brain Ischemia in the male Rats.

J Chem Neuroanat 2019 Apr 18. Epub 2019 Apr 18.

Clinical Neurology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran; Histomorphometry and Stereology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. Electronic address:

Stroke is a leading cause of mortality and disability; Memory impairment occurs frequently after stroke and the pattern of hippocampal CA1 pyramidal neurons has important role in the signal transmission and memory forming. G-CSF (granulocyte-colony stimulating factor) is a novel treatment that exhibits neuroprotective and anti-apoptotic in the central nervous system. The aim of the present study was to determine the effects of G-CSF on the neurobehavioral outcome and spatial pattern of CA1 pyramidal neurons after focal cerebral ischemia in animals. Read More

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http://dx.doi.org/10.1016/j.jchemneu.2019.04.007DOI Listing

Use of inspiratory profiles from patients with chronic obstructive pulmonary disease (COPD) to investigate drug delivery uniformity and aerodynamic dose emission of indacaterol from a capsule based dry powder inhaler.

Eur J Pharm Sci 2019 Apr 18. Epub 2019 Apr 18.

Department of Pharmacy and Pharmaceutical Sciences, University of Huddersfield, Huddersfield HD1 3DH, United Kingdom. Electronic address:

Most patients using dry powder inhalers (DPIs) are unable to achieve the inhalation parameters recommended for pharmacopoeial in-vitro dose emission testing. The dose emission characteristics of indacaterol Breezhaler (IB) have been measured using COPD patients' inhalation profiles (IPs) when using IB and replayed in-vitro using a breath simulator attached to an Andersen Cascade Impactor. The peak inhalation flow (PIF) of the profiles ranged from 28. Read More

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http://dx.doi.org/10.1016/j.ejps.2019.04.018DOI Listing

Prediction of Antioxidant proteins by incorporating statistical moments based features into Chou's PseAAC.

J Theor Biol 2019 Apr 18. Epub 2019 Apr 18.

Department of Computer Science, School of Systems and Technology, University of Management and Technology, Lahore, Pakistan.

Antioxidant proteins are considered crucial in the areas of research on life sciences and pharmacology. They prevent damage to cells and DNA which are caused by free radicals. The role of antioxidants in the ageing process makes them more significant in their accurate identification. Read More

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http://dx.doi.org/10.1016/j.jtbi.2019.04.019DOI Listing
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