5,436,530 results match your criteria Drug metabolism and disposition: the biological fate of chemicals[Journal]

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[Clinical features, treatment distribution and outcomes of Mooren's ulcer].

Zhonghua Yan Ke Za Zhi 2019 Feb;55(2):127-133

Qingdao Eye Hospital, Shandong Eye Institute, Qingdao 266071, China.

To investigate the clinical features, treatment distribution and transition of Mooren's ulcer, and to observe the clinical outcomes and recurrence. Retrospective series case study. Medical records of 125 patients (154 eyes) with Mooren's ulcer treated between January 1996 and December 2015 at our hospital were retrospectively reviewed. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0412-4081.2019.02.011DOI Listing
February 2019

Comparative Study of Frozen and Paraffin-Embedded Sections: Evaluation of Inflammatory Dermatoses.

Isr Med Assoc J 2019 Feb;21(2):82-84

Department of Dermatology, Sourasky Tel Aviv Medical Center, Tel Aviv, Israel.

Background: Frozen section (FS) is often performed when histopathological evaluations are urgently required for implementation of therapeutic measures. In dermatology, this method is most commonly used to evaluate excision margins of tumors. FS are also routinely employed to differentiate toxic epidermal necrolysis from staphylococcal scalded skin syndrome. Read More

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February 2019

The Clinical and Molecular Epidemiology of CTX-M-9 Group Producing Enterobacteriaceae Infections in Children.

Infect Dis Ther 2019 Feb 16. Epub 2019 Feb 16.

Research Service, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, OH, USA.

Introduction: The pandemic of extended-spectrum beta-lactamase-(ESBL)-producing Enterobacteriaceae (Ent) is strongly linked to the dissemination of CTX-M-type-ESBL-Ent. We sought to define the epidemiology of infections in children due to an emerging resistance type, CTX-M-9-group-producing-Ent (CTX-M-9-grp-Ent).

Methods: A retrospective matched case-control analysis of children with CTX-M-9-grp-Ent infections who received medical care at three Chicago area hospitals was performed. Read More

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http://dx.doi.org/10.1007/s40121-019-0237-2DOI Listing
February 2019

Effectiveness of individual and group multicomponent interventions for smoking cessation in primary care: a quasi-experimental study.

Fam Pract 2019 Feb 17. Epub 2019 Feb 17.

Servicio Extremeño de Salud, Centro de Salud Universitario 'La Paz', Unidad Docente de Medicina Familiar y Comunitaria, Departamento de Ciencias Biomédicas, Universidad de Extremadura, Badajoz, Spain.

Background: The efficacy of smoking cessation interventions can be quite diverse in day-to-day clinical practice.

Objective: To analyse the effectiveness in smoking cessation of multicomponent interventions carried out in groups or individually in primary care practices.

Methods: A quasi-experimental, multicentre study of 12-month follow-up of patients treated in multicomponent smoking cessation interventions was carried out in Urban health care centres in Sevilla, Spain. Read More

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http://dx.doi.org/10.1093/fampra/cmz005DOI Listing
February 2019

Patterns of high-risk prescribing and other factors in relation to receipt of a home medicines review: a prospective cohort investigation among adults aged 45 years and over in Australia.

BMJ Open 2019 Feb 15;9(2):e027305. Epub 2019 Feb 15.

Research School of Population Health, Australian National University, Canberra, Sydney, Australia.

Objectives: To quantify the relationship between home medicines review (HMR) receipt in older adults and sociodemographic, medication-related and health factors.

Design: Prospective cohort analysis.

Settings, Participants, Measurements: Questionnaire data from a population-based cohort study of individuals aged ≥45 years, Sydney, Australia were linked with primary healthcare data, medication and hospitalisation data, to ascertain factors associated with HMR receipt during the period July 2009-June 2014. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-027305DOI Listing
February 2019

Adolescent males' responses to blu's fake warnings.

Tob Control 2019 Feb 16. Epub 2019 Feb 16.

Division of Epidemiology, College of Public Health, The Ohio State University, Columbus, Ohio, USA.

Objective: Blu's 'Something Better' advertising campaign ran in popular print magazines in 2017. The campaign included advertisements with fake warnings conveying positive messages, which mimicked the Food and Drug Administration (FDA)'s warning requirements for electronic cigarette (e-cigarette) advertisements that took effect in 2018. We report adolescent males' recall of these fake warnings and how exposure to fake warnings affected recall of other advertisement components, including the actual warning or health risks, brand and product. Read More

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http://dx.doi.org/10.1136/tobaccocontrol-2018-054805DOI Listing
February 2019

Report: A case report on Nevirapine induced exfoliative dermatitis.

Pak J Pharm Sci 2019 Jan;32(1):221-222

Department of General Medicine, Rajiv Gandhi institute of medical sciences, Kadapa, India.

Drug induced adverse drug reactions is more common in long term therapy particularly in immune compromised patients. Most of the drugs causing dermatological reactions like skin rashes, pruritus, steven johnson syndrome and exfoliative dermatitis. Nevirapine is the first line drug for human immunodeficiency virus (HIV) infection from the category of non-nucleoside reverse transcriptase enzyme inhibitor (NNRTI). Read More

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January 2019

A retrospective study on evaluation of anti-hypertensive drugs used in gestational hypertension.

Pak J Pharm Sci 2019 Jan;32(1):213-215

Department of Pharmacy Practice, School of Pharmaceutical Sciences, Vels University, Chennai, Tamil Nadu, India.

To evaluate the anti-hypertensive drugs used in pregnancy induced hypertension and to determine the safety of the anti-hypertensive drugs administered in gestational hypertensive patients. Pregnancy induced hypertension are very common in women and if unnoticed may lead to severe complications. The appropriate therapy is very much essential for the welfare of both the mother and the child. Read More

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January 2019

Depletion of apomorphine induced behavioral sensitization in rats treated with escitalopram.

Pak J Pharm Sci 2019 Jan;32(1):197-203

Neurochemistry and Biochemical Neuropharmacology Research Unit, Department of Biochemistry, University of Karachi, Karachi, Pakistan.

Apomorphine is a classical psychostimulant and used throughout the world as prescribed medicine. Despite of their therapeutic effects, use of psychostimulants is restricted because some psychosis and impulse control disorders are the consequence of their long term use. Studies suggest that serotonin (5-Hydroxytryptamine; 5-HT) has a critical role in psychosis and drug abuse. Read More

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January 2019

Formulation development and in vitro evaluation of fast dispersible, taste masked aceclofenac compacted pellets.

Pak J Pharm Sci 2019 Jan;32(1):117-123

Department of Pharmaceutics, Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi, Karachi, Pakistan.

The objective of study was to develop Aceclofenac fast dispersible compacted pellets with improved taste and fast drug release. Pellets were prepared by extrusion spheronization technique followed by direct compression to make compacted pellets. Formulations were comprised of sucrose, mannitol, ac-di-sol, aspartame, pine apple flavor and magnesium stearate. Read More

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January 2019

A comparative study showing greater effects of curcumin compared to donepezil on memory function in rats.

Pak J Pharm Sci 2019 Jan;32(1):53-60

Neurochemistry and Biochemical Neuropharmacology Research Unit, Department of Biochemistry, University of Karachi, Karachi, Pakistan.

Curcumin possesses wide spectrum of biological actions, on that account the current study was aimed to investigate the beneficial effectiveness of curcumin on memory and oxidative stress if any, over synthetic drug donepezil approved for the treatment of memory disorders. Eighteen Albino wistar (male) rats were divided into 3 groups namely vehicle control which received neutral oil orally and 0.9% saline intraperitoneally, curcumin which received curcumin orally dissolved in neutral oil at the dose of 100mg/ml/kg for seven days, donepezil which received donepezil intraperitoneally at the dose of 1mg/ml/kg for seven days. Read More

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January 2019

Preventive and therapeutic effects of aqueous extract of Spinacia oleracea on Psoriatic patches in albino rats.

Pak J Pharm Sci 2019 Jan;32(1):35-42

Department of Pharmacology, Faculty of Pharmacy & Pharmaceutical Sciences, University of Karachi, Karachi, Pakistan.

Psoriasis has become a topic of global concern because of consistency in its prevalence according to Global Report on Psoriasis 2016, however, till date, no therapy has provided complete cure of this disease and no useful measure was discovered to prevent it or eliminate the risk of its relapse. Hence, the present study was designed to evaluate anti-psoriatic effects of Spinacia oleracea due to its anti-inflammatory, anti-oxidant, anti-proliferative and skin-strengthening contents. Psoriasis was induced by oral potassium iodide solution which was then determined by two methods i. Read More

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January 2019

Healing effects of Pergularia tomentosa L., a native medicinal plant in Bushehr province, Iran on burn, in animal model.

Pak J Pharm Sci 2019 Jan;32(1):21-28

Department of Marine Toxinology, The Persian Gulf Marine Biotechnology Research Center, Bushehr University of Medical Sciences, Bushehr, Iran.

Burn injury is one of the most destructive events in the world. The Pergularia tomentosa L. is a medicinal plant that traditionally, applies for treatment of burning, in Bushehr province, Iran. Read More

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January 2019

Thiosemicarbazone and thiazolylhydrazones of 1-indanone: As a new class of nonacidic anti-inflammatory and antiplatelet aggregation agents.

Pak J Pharm Sci 2019 Jan;32(1):15-19

Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan.

This research based on the anti-inflammatory and antiplatelet aggregation properties of some new thiazolyl hydrazone derivatives of 1-indanone. In this regard a thiosemicabazone and twelve thiazolyl derivatives of 1-indanone have been synthesized. Out of these synthetic compounds seven derivatives 1-3, 6, 11-13 exhibited varying degree of anti-inflammatory action with IC esteems going from 5. Read More

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January 2019

Gastroprotective and antioxidant potential of Euphorbia prostrata against aspirin induced gastric ulcers in rabbits.

Pak J Pharm Sci 2019 Jan;32(1):7-13

Institute of Pharmacy, Physiology and Pharmacology, University of Agriculture, Faisalabad, Pakistan.

Present study was planned to estimate the gastroprotective activity of Euphorbia prostrata plant against aspirin induced gastric ulcers in male adult albino rabbits. The ulcer was induced by oral administration of aspirin in all groups except normal control group. Gastric contents were used to estimate total acid output, gastric volume and gastric pH. Read More

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January 2019

Corrigendum to "Fentanyl and heroin contained in seized illicit drugs and overdose-related deaths in British Columbia, Canada: An observational analysis" [Drug Alcohol Depend. 185 (2018) 322-327].

Drug Alcohol Depend 2019 Feb 14;197:48. Epub 2019 Feb 14.

Department of Family Practice, University of British Columbia, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.drugalcdep.2019.02.001DOI Listing
February 2019

Prenatal alcohol exposure and facial morphology in a UK cohort.

Drug Alcohol Depend 2019 Feb 5;197:42-47. Epub 2019 Feb 5.

MRC Integrative Epidemiology Unit, Population Health Sciences, Oakfield House, Oakfield Grove, University of Bristol, BS8 2BN, UK; Bristol Dental School, University of Bristol, UK. Electronic address:

Background: High levels of prenatal alcohol exposure are known to cause an array of adverse outcomes including fetal alcohol syndrome (FAS); however, the effects of low to moderate exposure are less-well characterized. Previous findings suggest that differences in normal-range facial morphology may be a marker for alcohol exposure and related adverse effects.

Methods: In the Avon Longitudinal Study of Parents and Children, we tested for an association between maternal alcohol consumption and six FAS-related facial phenotypes in their offspring, using both self-report questionnaires and the maternal genotype at rs1229984 in ADH1B as measures of maternal alcohol consumption. Read More

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http://dx.doi.org/10.1016/j.drugalcdep.2018.11.031DOI Listing
February 2019

The role of energy drink consumption in the intention to initiate marijuana use among adolescents.

Addict Behav 2019 Feb 10;93:240-245. Epub 2019 Feb 10.

Department of Criminal Justice, The University of Texas at San Antonio, 501 W. Cesar E. Chavez Blvd., San Antonio, TX, 78207, United States. Electronic address:

Aims: The current study aims to examine whether energy drink consumption is associated with intentions to try marijuana among adolescents who have never tried marijuana, and whether the effects of energy drink consumption on the intention to try marijuana vary between adolescents who have previously tried alcohol or cigarettes and those who have not.

Methods: This study employs a pooled cross-sectional design and uses a nationally representative sample of 8th (ages 13-14) and 10th (ages 15-16) grade adolescents from seven recent cohorts (2010-2016) of the Monitoring the Future (MTF) study. Logistic regression was employed to examine the association between energy drink consumption (none, light, moderate, heavy) and the odds of intending to initiate marijuana use in the next 12 months, controlling for sociodemographic factors and other health and social behaviors. Read More

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http://dx.doi.org/10.1016/j.addbeh.2019.02.008DOI Listing
February 2019

Synthetic cannabinoid use among college students.

Addict Behav 2019 Feb 11;93:219-224. Epub 2019 Feb 11.

Psychiatry Residency Program, Louisiana State University Health Sciences Center, Baton Rouge, LA, United States; Louisiana State University, Department of Psychology, Baton Rouge, LA, United States.

Background And Objectives: Synthetic cannabinoid use is associated with severe problems, including psychosis, kidney failure, and death. Given that young adults are especially vulnerable to using synthetic cannabinoids, the current study sought to identify factors and consequences related to use within this population.

Methods: 1140 undergraduates completed an online survey of synthetic cannabinoid use, consequences, and related constructs. Read More

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http://dx.doi.org/10.1016/j.addbeh.2019.02.009DOI Listing
February 2019

Transdermal buprenorphine patch: Potential for role in management of opioid dependence.

Asian J Psychiatr 2019 Feb 10;40:88-91. Epub 2019 Feb 10.

All India Institute for Medical Sciences, New Delhi, 110029, India.

Despite proven clinical utility, use of sublinugual buprenorphine is fraught with issues of potential diversion among patients with opioid dependence. Transdermal buprenorphine patches provide an alternative delivery model that can be utilized to reduce such diversion. This narrative review discusses the transdermal buprenorphine formulations, and its pharmacology, drug interaction and tolerability profile. Read More

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http://dx.doi.org/10.1016/j.ajp.2019.02.002DOI Listing
February 2019

GMP-compatible manufacturing of three iPS cell lines from human peripheral blood.

Stem Cell Res 2019 Feb 11;35:101394. Epub 2019 Feb 11.

Leibniz Research Laboratories for Biotechnology and Artificial Organs (LEBAO), REBIRTH Cluster of Excellence, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany.

The utilization of human induced pluripotent stem cells (hiPSCs) for disease modeling and drug discovery is already reality, and several first-in-man-applications as cellular therapeutics have been initiated. Implementation of good manufacturing practice (GMP)-compliant protocols for the generation of hiPSC lines is crucial to increase the application safety as well as to fulfil the legal requirements for clinical trials approval. Here we describe the development of a GMP-compatible protocol for the reprogramming of CD34 hematopoietic stem cells from peripheral blood (CD34 PBHSC) into hiPSCs using Sendai virus-based reprogramming vectors. Read More

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http://dx.doi.org/10.1016/j.scr.2019.101394DOI Listing
February 2019

Biocompatibility and effectiveness of paclitaxel-encapsulated micelle using phosphoester compounds as a carrier for cancer treatment.

Colloids Surf B Biointerfaces 2019 Feb 8;177:356-361. Epub 2019 Feb 8.

Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641, Yamazaki, Noda, Chiba 278-8510, Japan; Center for Drug Delivery Research, Tokyo University of Science, 2641, Yamazaki, Noda, Chiba 278-8510, Japan. Electronic address:

Phosphoester compounds are promising materials with expected biocompatibility; however, little has been reported on the use of phosphoester compounds for micelle formulations. In this study, paclitaxel (PTX)-encapsulated micelles were prepared using four kinds of alkyl di(MePEG-lactate) phosphates. From the results of the determination of critical micelle concentrations and an in vitro stability test, it was shown that a compound to which 1-eicosanol was introduced as a side chain was desirable in the preparation of PTX-encapsulated micelles (PTX-micelles). Read More

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http://dx.doi.org/10.1016/j.colsurfb.2019.02.017DOI Listing
February 2019

One-pot synthesis of polypyrrole nanoparticles with tunable photothermal conversion and drug loading capacity.

Colloids Surf B Biointerfaces 2019 Feb 8;177:346-355. Epub 2019 Feb 8.

College of Science, University of Shanghai for Science and Technology, No. 334 Jungong Road, Shanghai, 200093, China. Electronic address:

With an excellent near-infrared (NIR) light-responsive property, polypyrrole (PPy) nanoparticle has emerged as a promising NIR photothermal transducing agent for tumor photothermal therapy (PTT). Herein, we reported the PVP mediated one-pot synthesis of colloidal stable and biocompatible PPy nanoparticles (PPy-PVP NPs) for combined tumor photothermal-chemotherapy. The influence of molecular weight and PVP concentration on the spectroscopic characteristic, photothermal feature, drug loading performance, and antitumor efficiency of the resultant PPy-PVP NPs was systematically studied. Read More

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http://dx.doi.org/10.1016/j.colsurfb.2019.02.016DOI Listing
February 2019

PEO-b-PCL grafted niosomes: The cooperativilty of amphiphilic components and their properties in vitro and in vivo.

Colloids Surf B Biointerfaces 2019 Jan 22;177:338-345. Epub 2019 Jan 22.

Centre of Polymer and Carbon Materials, Polish Academy of Sciences, Zabrze, Poland.

Niosomes belong to drug delivery systems and consist mainly of non-ionic surfactants and cholesterol. In this study, we designed and developed systems composed of non-ionic surfactants i.e. Read More

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http://dx.doi.org/10.1016/j.colsurfb.2019.01.036DOI Listing
January 2019

ACCELERATE and European Medicine Agency Paediatric Strategy Forum for medicinal product development for mature B-cell malignancies in children.

Eur J Cancer 2019 Feb 14;110:74-85. Epub 2019 Feb 14.

Department of Clinical Research, Gustave Roussy, Paris-Sud University, Paris, France.

Paediatric Strategy Forums have been created by the multistakeholder organisation, ACCELERATE, and the European Medicines Agency to facilitate dialogue between all relevant stakeholders and suggest strategies in critical areas of paediatric oncology drug development. As there are many medicines being developed for B-cell malignancies in adults but comparatively few in children with these malignancies, a Paediatric Strategy Forum was held to discuss the best approach to develop these products for children. It was concluded that as current frontline therapy is highly successful, despite associated acute toxicity, de-escalation of this or substitution of presently used drugs with new medicines can only be undertaken when there is an effective salvage regimen, which is currently not available. Read More

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http://dx.doi.org/10.1016/j.ejca.2019.01.013DOI Listing
February 2019

Investigation on the effect of alkyl chain linked mono-thioureas as Jack bean urease inhibitors, SAR, pharmacokinetics ADMET parameters and molecular docking studies.

Bioorg Chem 2019 Feb 8;86:473-481. Epub 2019 Feb 8.

Department of Biological Sciences, College of Natural Sciences, Kongju National University, 56 Gongjudehak-Ro, Gongju, Chungnam 314-701, Republic of Korea.

The increasing resistance of pathogens to common antibiotics, as well as the need to control urease activity to improve the yield of soil nitrogen fertilization in agricultural applications, has stimulated the development of novel classes of molecules that target urease as an enzyme. In this context, the newly developed compounds on the basis of 1-heptanoyl-3-arylthiourea family were evaluated for Jack bean urease enzyme inhibition activity to validate their role as potent inhibitors of this enzyme. 1-Heptanoyl-3-arylthioureas were obtained in excellent yield and characterized through spectral and elemental analysis. Read More

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http://dx.doi.org/10.1016/j.bioorg.2019.02.011DOI Listing
February 2019

Pyranocarbazole derivatives as potent anti-cancer agents triggering tubulin polymerization stabilization induced activation of caspase-dependent apoptosis and downregulation of Akt/mTOR in breast cancer cells.

Eur J Med Chem 2019 Feb 7;167:226-244. Epub 2019 Feb 7.

Division of Medicinal and Process Chemistry, CSIR-Central Drug Research Institute, BS-10/1, Sector 10, Jankipuram Extension, Sitapur Road, Lucknow 226031, Uttar Pradesh, India; Academy of Scientific and Innovative Research, CSIR-Central Drug Research Institute, BS-10/1, Sector 10, Jankipuram Extension, Sitapur Road, Lucknow 226031, Uttar Pradesh, India. Electronic address:

A series of new pyranocarbazole derivatives were synthesized via semi-synthetic modification of koenimbine (1a) and koenidine (1b) isolated from the leaves of Murraya koenigii. Among all, compound 3bg displayed significant anti-cancer activity against MDA-MB-231, DU145 and PC3 cell lines with the IC values of 3.8, 7. Read More

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http://dx.doi.org/10.1016/j.ejmech.2019.02.003DOI Listing
February 2019

Synthesis and evaluation of novel GSK-3β inhibitors as multifunctional agents against Alzheimer's disease.

Eur J Med Chem 2019 Feb 8;167:211-225. Epub 2019 Feb 8.

Institute of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, Jinan, 250012, PR China. Electronic address:

To target the multi-facets of Alzheimer's disease (AD), a series of novel GSK-3β inhibitors containing the 2,3-diaminopyridine moiety were designed and synthesized. The amide derivatives 5a-f showed moderate potency against GSK-3β with weak Cu, Zn and Al chelating ability. The imine derivatives 9a, 9b and 9e were potent GSK-3β inhibitors and selective Cuand Al chelators. Read More

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http://dx.doi.org/10.1016/j.ejmech.2019.02.001DOI Listing
February 2019

Comprehensive analysis on sorptive uptake of enrofloxacin by activated carbon derived from industrial paper sludge.

Sci Total Environ 2019 Feb 8;665:438-452. Epub 2019 Feb 8.

Chemical Engineering Department, National Institute of Technology Durgapur, India. Electronic address:

The current investigation deals with how chemically activated carbon derived from industrial paper sludge (ACPS) performs on sorptive removal of enrofloxacin (ENF), an antibacterial drug from its water solution. Thermogravimetric (TGA) and proximate analysis of raw paper sludge (RPS) were conducted. ACPS was characterized with proximate analysis, XRD, FT-IR, SEM and BET. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2019.02.081DOI Listing
February 2019

Dissemination of Escherichia coli carrying plasmid-mediated quinolone resistance (PMQR) genes from swine farms to surroundings.

Sci Total Environ 2019 Jan 25;665:33-40. Epub 2019 Jan 25.

College of Animal Science and Veterinary Medicine, Shandong Agricultural University, Sino-German Cooperative Research Centre for Zoonosis of Animal Origin Shandong Province, 61 Daizong Road, Tai'an 271000, Shandong Province, China. Electronic address:

Different samples were collected from three swine farms in China to investigate the spread of antibiotic-resistant Escherichia coli. A total of 130 E. coli isolates were obtained from feces, air, river water, silt, and soil samples and characterized. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2019.01.272DOI Listing
January 2019

Macromolecular inversion-driven polymer insertion into model lipid bilayer membranes.

J Colloid Interface Sci 2019 Jan 30;542:483-494. Epub 2019 Jan 30.

School of Chemical Sciences, Dublin City University, Dublin 9, Ireland. Electronic address:

Macromolecules of amphiphilic invertible polymers (AIPs) are capable of self-assembly into micellar assemblies of various morphologies in solvents of different polarities. The micellar assemblies in aqueous media are capable of encapsulating poorly aqueous soluble cargo and can undergo inverse conformational change and cargo release in contact with non-polar media, including potentially, cell membranes. Thus, invertible micellar assemblies have significant potential in drug delivery and related domains. Read More

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http://dx.doi.org/10.1016/j.jcis.2019.01.093DOI Listing
January 2019

Wrapped stellate silica nanocomposites as biocompatible luminescent nanoplatforms assessed in vivo.

J Colloid Interface Sci 2019 Jan 23;542:469-482. Epub 2019 Jan 23.

Institut de Physique et Chimie des Matériaux de Strasbourg (IPCMS), UMR-7504, CNRS-Université de Strasbourg, 23 rue du Loess, BP 34 67034, Strasbourg Cedex 2, France. Electronic address:

The engineering of luminescent nanoplatforms for biomedical applications displaying ability for scaling-up, good colloidal stability in aqueous solutions, biocompatibility, and providing an easy detection in vivo by fluorescence methods while offering high potential of functionalities, is currently a challenge. The original strategy proposed here involves the use of large pore (ca. 15 nm) mesoporous silica (MS) nanoparticles (NPs) having a stellate morphology (denoted STMS) on which fluorescent InP/ZnS quantum dots (QDs) are covalently grafted with a high yield (≥90%). Read More

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http://dx.doi.org/10.1016/j.jcis.2019.01.098DOI Listing
January 2019

Tenacigenin B ester derivatives from Marsdenia tenacissima actively inhibited CYP3A4 and enhanced in vivo antitumor activity of paclitaxel.

J Ethnopharmacol 2019 Feb 14. Epub 2019 Feb 14.

Laboratory of Chinese Herbal Drug Discovery, Institute of Tropical Medicine, Guangzhou University of Chinese Medicine, Guangzhou 510405, Guangdong, P.R. China. Electronic address:

Ethnopharmacological Relevance: Marsdenia tenacissima (Roxb.) Wight et Arn is a vine distributed in southwest area of China and used in folk medicine for treatment of tumors. Recent decades of studies on this plant reveal its synergistic effects with certain anticancer drugs in cancer therapy. Read More

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http://dx.doi.org/10.1016/j.jep.2019.02.028DOI Listing
February 2019

Therapeutics strategies against cancer stem cell in breast cancer.

Int J Biochem Cell Biol 2019 Feb 14. Epub 2019 Feb 14.

Cancer Gene Therapy Research Center (CGRC), Zanjan University of Medical Sciences, Zanjan, Iran. Electronic address:

Breast cancer is known as a most prevalent cancer and second deadly cancer, among women worldwide. Due to the high incidence rate of breast cancer and limitations of conventional therapy it seemed essential to look for new targets in cancer cells and directly target them such as target therapy on breast cancer stem cells. In this review we indicate some of therapeutic uses of cancer stem cells in breast cancer. Read More

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http://dx.doi.org/10.1016/j.biocel.2019.01.015DOI Listing
February 2019

Trends in Asthma Control, Treatment, Healthcare Utilization and Expenditures among Children in the United States by Place of Residence: 2003-2014.

J Allergy Clin Immunol Pract 2019 Feb 14. Epub 2019 Feb 14.

Novartis Pharmaceuticals Corporation, East Hanover, NJ.

Background: Examining national trends in asthma treatment and control is essential to inform treatment and public health initiatives.

Objective: Explore national trends in asthma control and treatment over time among children and those residing in poor-urban areas.

Methods: This was an analysis of trends from 2003-2014 among children (aged 1-17) in the Medical Expenditure Panel Survey (MEPS). Read More

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http://dx.doi.org/10.1016/j.jaip.2019.01.055DOI Listing
February 2019

Clinical Risk Factors Associated with Multidrug-Resistant Tuberculosis (MDR-TB) in Mali.

Int J Infect Dis 2019 Feb 14. Epub 2019 Feb 14.

University Clinical Research Center (UCRC)- SEREFO Laboratory, University of Sciences, Techniques and Technologies of Bamako (USTTB), Bamako, Mali. Electronic address:

Background: MDR-TB is a major threat to global TB control. In 2015, 580,000 were treated for MDR-TB worldwide. The worldwide roll-out of GeneXpert MTB/RIF has improved diagnosis of MDR-TB; however, in many countries laboratories are unable to assess drug resistance and clinical predictors of MDR-TB could help target suspected patients. Read More

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http://dx.doi.org/10.1016/j.ijid.2019.02.004DOI Listing
February 2019

Chemical genetic screen identifies Gapex-5/GAPVD1 and STBD1 as novel AMPK substrates.

Cell Signal 2019 Feb 14. Epub 2019 Feb 14.

Nestlé Institute of Health Sciences SA, Ecole Polytechnique Fédérale de Lausanne (EPFL), Innovation Park, bâtiment G, 1015 Lausanne, Switzerland; School of Life Sciences, EPFL, 1015 Lausanne, Switzerland. Electronic address:

AMP-activated protein kinase (AMPK) is a key regulator of cellular energy homeostasis, acting as a sensor of energy and nutrient status. As such, AMPK is considered a promising drug target for treatment of medical conditions particularly associated with metabolic dysfunctions. To better understand the downstream effectors and physiological consequences of AMPK activation, we have employed a chemical genetic screen in mouse primary hepatocytes in an attempt to identify novel AMPK targets. Read More

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http://dx.doi.org/10.1016/j.cellsig.2019.02.001DOI Listing
February 2019

Deep-Resp-Forest: A deep forest model to predict anti-cancer drug response.

Methods 2019 Feb 14. Epub 2019 Feb 14.

Institute of Fundamental and Frontier Sciences, University of Electronic Science and Technology of China, Chengdu, China. Electronic address:

The identification of therapeutic biomarkers predictive of drug response is crucial in personalized medicine. A number of computational models to predict response of anti-cancer drugs have been developed as the establishment of several pharmacogenomics screening databases. In our study, we proposed a deep cascaded forest model, Deep-Resp-Forest, to classify the anti-cancer drug response as "sensitive" or "resistant". Read More

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http://dx.doi.org/10.1016/j.ymeth.2019.02.009DOI Listing
February 2019

The paraventricular thalamic nucleus: A key hub of neural circuits underlying drug addiction.

Pharmacol Res 2019 Feb 14. Epub 2019 Feb 14.

Guangdong Provincial Key Laboratory of Brain Connectome and Behavior, The Brain Cognition and Brain Disease Institute, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, China. Electronic address:

Drug addiction is a chronic relapsing brain disease characterized by compulsive, out-of-control drug use and the appearance of negative somatic and emotional consequences when drug access is prevented. The limited efficacy of treatment urges researchers toward a deeper understanding of the neural mechanism of drug addiction. Brain circuits that regulate reward and motivation are considered to be the neural substrate of drug addiction. Read More

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http://dx.doi.org/10.1016/j.phrs.2019.02.014DOI Listing
February 2019

Combination of microneedles and microemulsions to increase celecoxib topical delivery for potential application in chemoprevention of breast cancer.

Int J Pharm 2019 Feb 14. Epub 2019 Feb 14.

Department of Pharmacology, Institute of Biomedical Sciences, University of Sao Paulo, Brazil. Electronic address:

In spite of the high incidence of breast cancer worldwide, there are few strategies for its chemoprevention, and they have limited adherence mainly due to their serious adverse effects. As a new approach for local breast cancer chemoprevention, we developed and optimized microemulsions for topical delivery of celecoxib to the breast skin, and evaluated their combination with microneedles to improve drug penetration for localization in the mammary tissue. Microemulsions containing water at 15% (ME-15), 29% (ME-29) and 60% (ME-60) were obtained and characterized. Read More

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http://dx.doi.org/10.1016/j.ijpharm.2019.02.011DOI Listing
February 2019

Characterisation and optimisation of diclofenac sodium orodispersible thin film formulation.

Int J Pharm 2019 Feb 14. Epub 2019 Feb 14.

Department of Pharmaceutical Sciences, Institute of Pharmacy and Biomedical Sciences, University Of Strathclyde, Glasgow, UK.

Oral Thin Film (OTF) is a newly emerging drug delivery system which has many benefits for patients. Although there has been some formulation of OTF products, these have mainly been as confectionary or dental health products. The most significant benefit of this dosage format will only be realised once more pharmaceutical products become available. Read More

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http://dx.doi.org/10.1016/j.ijpharm.2019.01.064DOI Listing
February 2019

Chitosan and Chitosan Coating Nanoparticles for the Treatment of Brain Disease.

Int J Pharm 2019 Feb 14. Epub 2019 Feb 14.

Murad Research Center for Modernized Chinese Medicine, Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China; Key Laboratory of Smart Drug Delivery, Fudan University, Ministry of Education, Shanghai 201203, China. Electronic address:

Since the application of chitosan magnetic cationic microspheres in brain drug delivery by Gallo in 1993, chitosan has been extensively studied in brain drug delivery. As the only natural alkaline polysaccharide with good biocompatibility and biodegradability, chitosan prepared nanoparticles which use chitosan as carrier material to encapsulate drug have been proved with advantages of protecting from enzyme degradation, control release and improved bioavailability. Besides, chitosan can enhance drug permeability across the blood-brain barrier by affecting the tight junction. Read More

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http://dx.doi.org/10.1016/j.ijpharm.2019.02.012DOI Listing
February 2019

Detection of mcr-1-mediated colistin resistance in E. coli isolate from imported chicken meat from Brazil.

J Glob Antimicrob Resist 2019 Feb 14. Epub 2019 Feb 14.

Department of Bacteriology, Gunma University Graduate School of Medicine, 3-39-22 Showa-machi, Maebashi, Gunma, 371-8511, Japan; Laboratory of Bacterial Drug Resistance, Gunma University Graduate School of Medicine, 3-39-22 Showa-machi, Maebashi, Gunma, 371-8511, Japan.

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http://dx.doi.org/10.1016/j.jgar.2019.02.004DOI Listing
February 2019

Silk fibroin nanoparticles for Celecoxib and Curcumin delivery: ROS-scavenging and anti-inflammatory activities in an in vitro model of osteoarthritis.

Eur J Pharm Biopharm 2019 Feb 14. Epub 2019 Feb 14.

University of Pavia, Department of Drug Sciences, 27100 Pavia, Italy; Pharmaexceed srl, 27100 Pavia, Italy.

This paper aims at demonstrating silk fibroin nanoparticles (SFNs) promote anti-inflammatory properties of celecoxib (CXB) or curcumin (CUR), and could be exploited for osteoarthritis (OA) treatment. Nanoparticles were prepared by desolvation method and physico-chemically characterized (FT-IR, DSC, TGA, SEM, size distribution and drug release); empty and drug loaded nanoparticles were tested for their ROS-scavenging activity, hemolytic properties, cytotoxicity, and anti-inflammatory potency in an OA in vitro model. Results indicate that a controlled drug release has been achieved by varying the drug loading. Read More

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http://dx.doi.org/10.1016/j.ejpb.2019.02.008DOI Listing
February 2019

The antipsychotic-like effects of clozapine in C57BL/6 mice exposed to cuprizone: decreased glial activation.

Behav Brain Res 2019 Feb 14. Epub 2019 Feb 14.

Beijing Tiantan Hospital, Capital Medical University, Advanced Innovation Center for Human Brain Protection, Capital Medical University, China National Clinical Research Center for Neurological Diseases, No. 119 South 4th Ring Road West, Fengtai District, Beijing, 100070, PR China. Electronic address:

Cuprizone (CPZ), a copper chelator that has been shown to selectively damage white matter, can induce a novel animal model to mimic some symptoms of schizophrenia. This study aimed to examine the effect of clozapine (CLZ) on behavioural changes induced by CPZ exposure and try to explore the underlying mechanisms. Behavioural abnormalities associated with feeding mice a 0. Read More

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http://dx.doi.org/10.1016/j.bbr.2019.02.026DOI Listing
February 2019

Control and regulation of the pyrophosphate-dependent glucose metabolism in Entamoeba histolytica.

Mol Biochem Parasitol 2019 Feb 14. Epub 2019 Feb 14.

Departamento de Bioquímica, Instituto Nacional de Cardiología Ignacio Chávez, Ciudad de México, 14080, Mexico.

Entamoeba histolytica has neither Krebs cycle nor oxidative phosphorylation activities; therefore, glycolysis is the main pathway for ATP supply and provision of carbon skeleton precursors for the synthesis of macromolecules. Glucose is metabolized through fermentative glycolysis, producing ethanol as its main end-product as well as some acetate. Amoebal glycolysis markedly differs from the typical Embden-Meyerhof-Parnas pathway present in human cells: (i) by the use of inorganic pyrophosphate, instead of ATP, as the high-energy phospho group donor; (ii) with one exception, the pathway enzymes can catalyze reversible reactions under physiological conditions; (iii) there is no allosteric regulation and sigmoidal kinetic behavior of key enzymes; and (iv) the presence of some glycolytic and fermentation enzymes similar to those of anaerobic bacteria. Read More

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http://dx.doi.org/10.1016/j.molbiopara.2019.02.002DOI Listing
February 2019

Drug Hypersensitivity Reactions in the Americas: Similarities and Differences.

Ann Allergy Asthma Immunol 2019 Feb 14. Epub 2019 Feb 14.

Tan Tock Seng Hospital, Singapore, Singapore.

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http://dx.doi.org/10.1016/j.anai.2019.02.007DOI Listing
February 2019

Drug Induced Enterocolitis Syndrome (DIES): a clinical entity which deserves more awareness.

Ann Allergy Asthma Immunol 2019 Feb 14. Epub 2019 Feb 14.

Erasmus MC University Medical Center, Department of Pediatrics, division of Respiratory Medicine and Allergology, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.anai.2019.02.004DOI Listing
February 2019

Adverse Reactions to Fluorescein Angiography: A Comprehensive Review of the Literature.

Surv Ophthalmol 2019 Feb 14. Epub 2019 Feb 14.

University of Texas Medical Branch, Department of Ophthalmology and Visual Sciences, 700 University Blvd. alveston, TX 77555. Electronic address:

We reviewed literature on adverse reactions to intravenous fluorescein angiography (IVFA) using PubMed and found 78 articles in English from 1961-2017. The reported rates of adverse reactions were overall 0.083-21. Read More

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http://dx.doi.org/10.1016/j.survophthal.2019.02.004DOI Listing
February 2019
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