1,739 results match your criteria Drug and Chemical Toxicology [Journal]


In vitro cytotoxicity, cellular uptake, reactive oxygen species and cell cycle arrest studies of novel ruthenium(II) polypyridyl complexes towards A549 lung cancer cell line.

Drug Chem Toxicol 2019 Apr 17:1-11. Epub 2019 Apr 17.

b School of Food Science and Environmental Health, Technological University Dublin , Dublin , Ireland.

Ruthenium(II) polypyridyl complexes have displayed some promising biological responses against a variety of cancers and have emerged as a potential candidate that can show significant antitumor activity. Three ruthenium(II) polypyridyl complexes were biologically evaluated in vitro against the A549 cancer cell line. The complexes were selected based on initial DNA intercalation studies and MTT viability screening and were selected based on the most promising candidates, the [Ru(bpy)o-CPIP]. Read More

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http://dx.doi.org/10.1080/01480545.2019.1589492DOI Listing

Effect of pesticide exposure on total antioxidant capacity and biochemical parameters in Brazilian soybean farmers.

Drug Chem Toxicol 2019 Apr 5:1-7. Epub 2019 Apr 5.

a Health Sciences Institute, Feevale University , Novo Hamburgo , Brazil.

Farmers represent a population highly vulnerable to the toxic effects of pesticide exposure. Antioxidant capacity and biochemical parameters have been used as biomarkers of occupational exposure to pesticides. The aim of this study was to evaluate hepatic and renal parameters as well as butyrylcholinesterase (BChE) activity and ferric-reducing ability of plasma (FRAP) considering high and low exposure periods in soybean farmers in southern Brazil. Read More

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http://dx.doi.org/10.1080/01480545.2019.1566353DOI Listing
April 2019
1 Read

Evaluation of in vitro and in vivo genotoxic and antigenotoxic effects of Rhus coriaria.

Drug Chem Toxicol 2019 Apr 4:1-9. Epub 2019 Apr 4.

a Faculty of Science and Letters, Department of Biology , Cukurova University , Adana , Turkey.

Rhus coriaria has been important in the treatment of many diseases in traditional use. In this content, the genotoxic, antigenotoxic, and oxidative stress effects of methanol extract of R. coriaria (RCE) were investigated in this study. Read More

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http://dx.doi.org/10.1080/01480545.2019.1593433DOI Listing
April 2019
1 Read

Gold and silver nanoparticles effects to the earthworm Eisenia fetida - the importance of tissue over soil concentrations.

Drug Chem Toxicol 2019 Apr 4:1-18. Epub 2019 Apr 4.

b Department of Biology, Faculty of Science, Division of Zoology , University of Zagreb , Zagreb , Croatia.

To address and to compare the respective impact of gold and silver nanoparticles (Au and Ag NPs) in soil invertebrate, the earthworm Eisenia fetida was exposed to soil containing 2, 10, and 50 mg/kg of Au and Ag in both nanoparticulate and ionic forms for 10 days. Both metal NPs were 2-15 times less bioavailable than their ionic forms, and displayed similar transfer coefficients from soil to earthworm tissues. Both metal NPs triggered the onset of an oxidative stress as illustrated by increased glutathione S-transferase levels, decreased catalase levels, and increased malondialdehyde concentrations. Read More

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http://dx.doi.org/10.1080/01480545.2019.1567757DOI Listing
April 2019
2 Reads

Anti-inflammatory, anti-oxidant and hepatoprotective effects of lactoferrin in rats.

Drug Chem Toxicol 2019 Apr 2:1-8. Epub 2019 Apr 2.

d Faculty of Veterinary Medicine, Department of Toxicology and Forensic Medicine , Matrouh University , Mersa Matruh , Egypt.

Carbon tetrachloride (CCl) is a strong hepatotoxic agent. The ability of the anti-inflammatory agent, lactoferrin (LF), to alleviate hepatic inflammation in a Wistar rat model administered with carbon tetrachloride (CCl) was examined. Thirty male Wistar rats were segregated into 5 groups (6 rats per group): Control group, LF group (300 mg LF/kg b. Read More

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http://dx.doi.org/10.1080/01480545.2019.1585868DOI Listing
April 2019
7 Reads

Estimation of total arsenic contamination and exposure in Brazilian rice and infant cereals.

Drug Chem Toxicol 2019 Apr 2:1-9. Epub 2019 Apr 2.

a Post-graduate Program in Pharmaceutical Sciences , Federal University of Rio Grande do Sul , Porto Alegre , RS , Brazil.

Arsenic (As) causes health effects, especially cancer. Rice (Oryza sativa L.) can contain high As concentrations. Read More

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http://dx.doi.org/10.1080/01480545.2019.1591435DOI Listing
April 2019
1 Read

Biogenic synthesis and characterization of silver nanoparticles using aqueous leaf extract of Scoparia dulcis L. and assessment of their antimicrobial property.

Drug Chem Toxicol 2019 Mar 27:1-15. Epub 2019 Mar 27.

a Department of Biochemistry , Andhra University , Visakhapatnam , India.

Naturally occurring phytochemicals serve as an excellent substitute in synthesizing nanomaterials. A process for the synthesis of silver nanoparticles (AgNPs) from the aqueous leaf extract of naturally occurring Scoparia dulcis is described here. The extracellular formation of AgNPs occurred within few minutes upon incubation of S. Read More

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http://dx.doi.org/10.1080/01480545.2018.1505903DOI Listing

Gallic acid ameliorates sodium arsenite-induced renal and hepatic toxicity in rats.

Drug Chem Toxicol 2019 Mar 25:1-12. Epub 2019 Mar 25.

e Medicinal Plant Research Center , Ahvaz Jundishapur University of Medical Sciences , Ahvaz , Iran.

Chronic exposure to toxic inorganic arsenic results in the adverse health effects including skin lesions, cardiovascular diseases, diabetes, neurological disorders, and liver and kidney diseases. Gallic acid (GA) is an important phenolic compound, which could protect different tissues from oxidative stress induced damage. The present study investigated effects of GA against sodium arsenite (SA)-induced renal and hepatic toxicity. Read More

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https://www.tandfonline.com/doi/full/10.1080/01480545.2019.1
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http://dx.doi.org/10.1080/01480545.2019.1591434DOI Listing
March 2019
3 Reads
1.098 Impact Factor

Cardiotoxicity evaluation and comparison of diterpene alkaloids on zebrafish.

Drug Chem Toxicol 2019 Mar 21:1-8. Epub 2019 Mar 21.

a The Ministry of Education, Key Laboratory of standardization of Chinese herbal medicine , College of Pharmacy, Chengdu University of Traditional Chinese Medicine , Chengdu , China.

Diterpene alkaloids (DAs) have a broad spectrum of pharmacological activities, but exhibiting extremely serious cardiotoxicity to induce arrhythmia, heart arrest, even death. This study aimed to evaluate the cardiotoxicity of three diester diterpene alkaloids (DDAs) including aconitine (AC), mesaconitine (MAC), hypaconitine (HAC) and three monoester diterpene alkaloids (MDAs) including 14-α-benzoylaconine (BAC), 14-α-benzoylmesaconine (BMAC), 14-α-benzoylhypaconine (BHAC) on zebrafish. Firstly, the zebrafish embryos after a 72-hour post fertilization were treated with different doses of AC, MAC, HAC, and BAC, BMAC and BHAC for 2, 10 and 24 h, respectively. Read More

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http://dx.doi.org/10.1080/01480545.2019.1586916DOI Listing
March 2019
4 Reads

Oral exposure to aluminum leads to reduced nicotinic acetylcholine receptor gene expression, severe neurodegeneration and impaired hippocampus dependent learning in mice.

Drug Chem Toxicol 2019 Mar 20:1-9. Epub 2019 Mar 20.

a Neurobiology Laboratory, Department of Healthcare Biotechnology , Atta-ur-Rahman School of Applied Biosciences, National University of Sciences and Technology , Islamabad , Pakistan.

Aluminum (Al) is known for its neurotoxicity for over a century and is reported to have specifically high toxicity for cholinergic system. The effect of Al on muscarinic acetylcholine receptors is widely reported, but its effect on nicotinic acetylcholine receptors (nAChRs) is less well known. The aim of this study was to determine the effects of Al on hippocampus dependent learning and memory, function and expression of nAChRs in the hippocampus. Read More

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http://dx.doi.org/10.1080/01480545.2019.1587452DOI Listing
March 2019
1 Read

Citral presents cytotoxic and genotoxic effects in human cultured cells.

Drug Chem Toxicol 2019 Mar 20:1-6. Epub 2019 Mar 20.

a Department of Speech and Hearing Therapy , Facult of Philosophy and Sciences, São Paulo State University (UNESP) , São Paulo , Brazil.

Citral, 3,7-dimethyl-2,6-octadien-1-al, one of the main components of the essential oils obtained from several plants, is used as a food additive and as a fragrance for detergents, cosmetics and other toiletries. The literature shows disparity regarding citral genotoxicity. Thus, the main objective of our work was to evaluate the genotoxic effects of citral in human cell cultures, HepG2 and leukocytes. Read More

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http://dx.doi.org/10.1080/01480545.2019.1585445DOI Listing
March 2019
3 Reads

Hesperidin opposes the negative impact of cyclophosphamide on mice kidneys.

Drug Chem Toxicol 2019 Mar 20:1-6. Epub 2019 Mar 20.

b Department of Pathology, Faculty of Medicine , Minia University , El-Minia , Egypt.

The present investigation examined the prospective nephroprotective effect of hesperidin (HSN) in mice challenged with a single i.p. injection of cyclophosphamide (CPE) at a dose of 200 mg/kg. Read More

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http://dx.doi.org/10.1080/01480545.2018.1560467DOI Listing

Hematoprotective effects and antioxidant properties of β-glucan and vitamin C against acetaminophen-induced toxicity: an experimental study in rats.

Drug Chem Toxicol 2019 Mar 18:1-8. Epub 2019 Mar 18.

b Institute for Biological Research "Siniša Stanković" , University of Belgrade , Belgrade , Republic of Serbia.

Acetaminophen is widely used as an over-the-counter analgesic and antipyretic drug. The aim of the present study was to investigate the pro-oxidative effects of acetaminophen (300 mg/kg/day i.p. Read More

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http://dx.doi.org/10.1080/01480545.2019.1587451DOI Listing
March 2019
2 Reads

Ameliorative effects of melatonin against nano and ionic cobalt induced genotoxicity in two in vivo Drosophila assays.

Drug Chem Toxicol 2019 Mar 18:1-8. Epub 2019 Mar 18.

a Faculty of Sciences, Department of Biology , Akdeniz University , Antalya , Turkey.

The aim of this study is to evaluate the ameliorative effect of melatonin (MEL) against induced genotoxicity by cobalt (II) chloride (CoCl) and cobalt nanoparticles (CoNPs) (50 nm). Genotoxicity of CoCl and CoNPs were investigated using single cell gel electrophoresis (COMET) in Drosophila melanogaster hemocytes, which are blood cells of the Drosophila, and the somatic mutation and recombination test (SMART) was used to investigate mutant effects on the Drosophila wings. Three concentrations (0. Read More

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http://dx.doi.org/10.1080/01480545.2019.1585444DOI Listing

The toxicological effect of 4-week repeated intravenous injection of activin a/BMP-2 chimera and 2-week recovery study in Beagle dog.

Drug Chem Toxicol 2019 Mar 18:1-9. Epub 2019 Mar 18.

a Department of Orthopedic Surgery, College of Medicine , Seoul National University , Seoul , Korea.

The purposes of this study was to determine the toxicological effect of repeated intravenous administration of Activin A/BMP-2 chimera (AB204) in beagle dogs for a long period of four weeks and evaluate two-week recovery. AB204 was administered at doses of 0.08, 0. Read More

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http://dx.doi.org/10.1080/01480545.2019.1572181DOI Listing

Use of a non-hepatic cell line highlights limitations associated with cell-based assessment of metabolically induced toxicity.

Drug Chem Toxicol 2019 Mar 18:1-7. Epub 2019 Mar 18.

d School of Chemistry and Physics, Pietermaritzburg Campus, University of KwaZulu-Natal , Scottsville , South Africa.

Metabolically induced drug-toxicity is a major cause of drug failure late in drug optimization phases. Accordingly, in vitro metabolic profiling of compounds is being introduced at earlier stages of the drug discovery pipeline. An increasingly common method to obtain these profiles is through overexpression of key CYP450 metabolic enzymes in immortalized liver cells, to generate competent hepatocyte surrogates. Read More

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http://dx.doi.org/10.1080/01480545.2019.1585869DOI Listing

Genotoxicity of yellow shammah (smokeless tobacco) in murine bone marrow cells in vivo.

Drug Chem Toxicol 2019 Mar 15:1-6. Epub 2019 Mar 15.

b Department of Pharmaceutical Chemistry, College of Pharmacy , Jazan University, Jazan , Saudi Arabia.

Shammah is a traditional form of smokeless tobacco (ST) that is manufactured and used locally by people of Middle East with highest usage in Saudi Arabia, Yemen and Sudan. In Saudi Arabia, shammah comes in three variants: white, brown and yellow. In the present study, we investigated the genotoxicity of yellow shammah (YS) on bone marrow (BM) cells in vivo using mice. Read More

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http://dx.doi.org/10.1080/01480545.2019.1566351DOI Listing
March 2019
1 Read
1.098 Impact Factor

Potential renoprotective effects of silymarin against vancomycin-induced nephrotoxicity in rats.

Drug Chem Toxicol 2019 Mar 12:1-7. Epub 2019 Mar 12.

e Faculty of Medicine, Department of Histology and Embryology , Mersin University , Mersin , Turkey.

Silymarin (SLY), a flavonoid complex isolated from the seeds of Silybum marianum (Asteraceae), has antioxidant, anti-apoptotic, anti-inflammatory, and anti-lipid peroxidative effects. Vancomycin (VA), used for treating serious infections, has been associated with nephrotoxicity, which limits its use. Therefore, this study aimed to investigate the potential renoprotective effects of SLY on VA-induced nephrotoxicity using renal, apoptotic (caspase-3, caspase-8, and caspase-9 enzyme activities), and oxidative stress [nitric oxide (NO) and malondialdehyde (MDA)] markers; serum blood urea nitrogen (BUN) and creatinine levels; and histopathological examination. Read More

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http://dx.doi.org/10.1080/01480545.2019.1584208DOI Listing
March 2019
1 Read

Oral administration of ammonium metavanadate and potassium dichromate distorts the inflammatory reaction induced by turpentine oil injection in male rats.

Drug Chem Toxicol 2019 Mar 8:1-9. Epub 2019 Mar 8.

e Department of New Technology , Saint-Petersburg Pasteur Institute , Saint-Petersburg , Russia.

Heavy metal pollution is rapidly increasing in the environment. It has been shown that exposure to vanadium and chromium is able to alter the immune response. Nevertheless, the mechanisms by which these metal pollutants mediate their immunomodulatory effects are not completely understood. Read More

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http://dx.doi.org/10.1080/01480545.2019.1585446DOI Listing
March 2019
2 Reads
1.098 Impact Factor

Lichens exerts an anti-proliferative effect on human breast and lung cancer cells through induction of apoptosis.

Drug Chem Toxicol 2019 Mar 5:1-9. Epub 2019 Mar 5.

a Department of Biology, Faculty of Science and Arts , Bursa Uludag University , Bursa , Turkey.

Successful cancer treatment still requires new complexes or compounds from natural sources. Therefore, we investigated anti-growth/apoptotic effects of methanol extracts of the lichen species (Xanthoparmelia somloensis (Gleyn.) Hale, Usnea intermedia (A. Read More

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http://dx.doi.org/10.1080/01480545.2019.1573825DOI Listing
March 2019
1 Read

In vitro toxicity evaluation of lomefloxacin-loaded MCM-41 mesoporous silica nanoparticles.

Drug Chem Toxicol 2019 Mar 1:1-12. Epub 2019 Mar 1.

d Department of Pharmaceutical Technology and Biopharmaceutics Faculty of Pharmacy , Medical University , Sofia , Bulgaria.

Lomefloxacin (LF) is interesting as a model molecule from a safety point of view because of its high potential for serious adverse drug effects (i.e. phototoxic reactions). Read More

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http://dx.doi.org/10.1080/01480545.2019.1571503DOI Listing

Molecular cloning, characterization of dax1 gene and its response to progesterone in Misgurnus anguillicaudatus.

Drug Chem Toxicol 2019 Mar 1:1-10. Epub 2019 Mar 1.

a College of Life Science , Henan Normal University , Xinxiang , Henan , People's Republic of China.

Progesterone (P4) are aquatic contaminants that can impair fish reproduction even in low concentrations. The aim of this study was to investigate the effects of P4 on the sex differentiation, by quantitative determination of transcriptional changes of a candidate target gene (dax1, has a function in the sex determination and gonadal differentiation of several vertebrate species) in Misgurnus anguillicaudatus. We first cloned and characterized the full-length cDNAs for the dax1 in M. Read More

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http://dx.doi.org/10.1080/01480545.2018.1461900DOI Listing
March 2019
1 Read

Effect of carvedilol versus propranolol on acute and chronic liver toxicity in rats.

Drug Chem Toxicol 2019 Feb 27:1-11. Epub 2019 Feb 27.

a Department of Pharmacology, Faculty of Medicine , King Abdulaziz University , Gedahh , Saudi Arabia.

Non-selective β-blockers have largely been used for prophylaxis of bleeding from gastroesophageal varices, but their hepatic effects and their influence on the development of varices has yet to be clarified. This study examined whether carvedilol would reduce acute and chronic liver injury in rats in comparison to propranolol. Experiment (1) Investigated the effects of carvedilol (1. Read More

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http://dx.doi.org/10.1080/01480545.2019.1576718DOI Listing
February 2019
1 Read

Determination of serum aflatoxin B-lysine and biochemical parameters in broiler chicks fed an aflatoxin B-contaminated diet.

Drug Chem Toxicol 2019 Feb 27:1-7. Epub 2019 Feb 27.

a Department of Food Engineering , School of Animal Science and Food Engineering, University of São Paulo , Pirassununga , Brazil.

In the present trial, the levels of serum aflatoxin B (AFB)-lysine and their relationship with biochemical parameters in broiler chicks fed an AFB-contaminated diet were determined. The experimental design was completely randomized with two treatments (control and 222.17 µg/kg AFB) and 20 bird per treatment. Read More

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http://dx.doi.org/10.1080/01480545.2019.1578786DOI Listing
February 2019
1 Read

Ameliorative effects of Moringa oleifera leaf extract on levofloxacin-induced hepatic toxicity in rats.

Drug Chem Toxicol 2019 Feb 20:1-7. Epub 2019 Feb 20.

b Department of Forensic Medicine and Toxicology, Faculty of Veterinary Medicine , Aswan University , Sahari , Aswan , Egypt.

Fluoroquinolones are some of the most common antibiotics used by clinicians all over the world. Levofloxacin, a fluoroquinolone, is used therapeutically in numerous countries; however, it can cause an increase in liver function tests and liver dysfunction. The current study was designed to determine the effect of Levofloxacin (40 mg/kg body weight (b. Read More

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http://dx.doi.org/10.1080/01480545.2019.1574811DOI Listing
February 2019
1 Read

Bufalin induces apoptosis via mitochondrial ROS-mediated caspase-3 activation in HCT-116 and SW620 human colon cancer cells.

Drug Chem Toxicol 2019 Feb 19:1-7. Epub 2019 Feb 19.

a Institute of Hepatobiliary Surgery, Southwest Hospital , Third Military Medical University (Army Medical University) , Chongqing , China.

Objective: Bufalin has been reported to kill various types of cancer including human colorectal cancer. Our previous study demonstrated that bufalin induced cell death via autophagy in HT-29 and Caco-2 colon cancer cells, but the action of bufalin remains unclear. This study was conducted to investigate the role of bufalin in other colon cancer HCT-116 and SW620 cells as well as its potential mechanism. Read More

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http://dx.doi.org/10.1080/01480545.2018.1512611DOI Listing
February 2019
1.098 Impact Factor

Evaluation of the anti-oxidant and anti-inflammatory effects of the methanolic extract of Ferula szowitsiana root on PHA-induced inflammation in human lymphocytes.

Drug Chem Toxicol 2019 Feb 14:1-8. Epub 2019 Feb 14.

c Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences , Mashhad , Iran.

Inflammation is defined as a defensive response of the body against either the endogenous or exogenous triggers, while this process becomes chronic leading to various disorders such as asthma, cancers, and multiple sclerosis. Recently, pharmacological properties of different constituents of F. szowitsiana have been reported. Read More

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http://dx.doi.org/10.1080/01480545.2019.1572182DOI Listing
February 2019
1 Read

Nanoformulations and their mode of action in insects: a review of biological interactions.

Drug Chem Toxicol 2019 Feb 13:1-11. Epub 2019 Feb 13.

a Department of Zoology , Lahore College for Women University , Lahore , Pakistan.

While nanoparticles (NPs) can be used as insecticides by themselves, they can also be carriers for insecticidal chemicals. Existing literature suggests that the smaller the NP size, the greater the toxicity and penetration into the insect's body. Nonetheless, there is a lack of literature pertaining to the mode of action within insects. Read More

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http://dx.doi.org/10.1080/01480545.2018.1525393DOI Listing
February 2019

Neuro-protective potential of quercetin during chlorpyrifos induced neurotoxicity in rats.

Drug Chem Toxicol 2019 Mar 12;42(2):220-230. Epub 2019 Feb 12.

a Department of Biophysics , Panjab University , Chandigarh , India.

Chlorpyrifos (CPF) has been considered as one of the most potent organophosphates and is linked to several neurological disorders. On the other hand, Quercetin is a vital plant flavanoid and has been reported to regulate a number of physiological processes in the central nervous system. The present study was conducted to investigate the protective potential of quercetin during chlorpyrifos induced neurotoxicity. Read More

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https://www.tandfonline.com/doi/full/10.1080/01480545.2019.1
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http://dx.doi.org/10.1080/01480545.2019.1569022DOI Listing
March 2019
6 Reads

The protective effect of Zataria multiflora Boiss essential oil on CCl induced liver fibrosis in rats.

Drug Chem Toxicol 2019 Feb 12:1-9. Epub 2019 Feb 12.

c Department of Clinical Studies, School of Veterinary Medicine , Shiraz University , Shiraz , Iran.

Activation of hepatic stellate cells by free radicals is an initial step in the development of liver fibrosis. Zataria multiflora Boiss (ZM) essential oil as a natural product has antioxidant activity and maybe a suitable candidate for treatment or prevention of the disease. Thus, this study aims to evaluate the protective effect of ZM oil in CCl induced liver fibrosis. Read More

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http://dx.doi.org/10.1080/01480545.2019.1571502DOI Listing
February 2019

miR-155 influences cell-mediated immunity in Balb/c mice treated with aflatoxin M.

Drug Chem Toxicol 2019 Feb 11:1-8. Epub 2019 Feb 11.

a Department of Pharmacodynamics and Toxicology, School of Pharmacy , Mashhad University of Medical Sciences , Mashhad , Iran.

Aflatoxin M (AFM) is a 4-hydroxylated metabolite of aflatoxin B (AFB). It induces various toxicological effects including immunotoxicity. In the present study, we investigated the effects of AFM on immune system and its modulation by MicroRNA (miR)-155. Read More

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http://dx.doi.org/10.1080/01480545.2018.1556682DOI Listing
February 2019
1 Read

Crocin as a novel therapeutic agent against colitis.

Drug Chem Toxicol 2019 Feb 3:1-8. Epub 2019 Feb 3.

a Department of Medical Physiology, Faculty of Medicine , Mashhad University of Medical Sciences , Mashhad , Iran.

Ulcerative colitis is a chronic inflammatory bowel disease with high incidence and prevalence worldwide. To investigate the therapeutic potency of crocin, as a pharmacologically active component of saffron, in dextran sodium sulfate (DSS)-induced colitis mice model. Experimental colitis was induced by 7-day administration of DSS dissolved in water at a concentration of 1. Read More

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http://dx.doi.org/10.1080/01480545.2018.1527850DOI Listing
February 2019
7 Reads
1.098 Impact Factor

Protective effect of aminoguanidine against lipopolysaccharide-induced hepatotoxicity and liver dysfunction in rat.

Drug Chem Toxicol 2019 Jan 29:1-7. Epub 2019 Jan 29.

e Department of Physiology , School of Medicine, Jiroft University of Medical Sciences , Jiroft , Iran.

Lipopolysaccharide (LPS) as the major component of the outer membrane of Gram-negative bacteria activates macrophages to produce a high level of pro-inflammatory cytokines which is considered as a cause of liver dysfunction. Overproduction of nitric oxide (NO) has been suggested to have a role in hepatic injury. The aim of the present study was to explore the protective effects of aminoguanidine (AG) as inducible nitric oxide synthase (iNOS) inhibitor against LPS -induced liver dysfunction in rat. Read More

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http://dx.doi.org/10.1080/01480545.2018.1561712DOI Listing
January 2019
2 Reads

Anti-hyperglycemic and genotoxic studies of 1-O-methyl chrysophanol, a new anthraquinone isolated from Amycolatopsis thermoflava strain SFMA-103.

Drug Chem Toxicol 2019 Jan 7:1-13. Epub 2019 Jan 7.

a Medicinal Chemistry and Biotechnology Division , CSIR-Indian Institute of Chemical Technology , Hyderabad , India.

The compound 1-O-methyl chrysophanol (OMC) which belongs to a class of hydroxyanthraquinones was isolated from Amycolatopsis thermoflava strain SFMA-103 and studied for their anti-diabetic properties. OMC was evaluated as an anti-diabetic agent based on in silico studies which initially predicted the binding energy with α-amylase (-188.81 KJ mol) and with α-glucosidase (70. Read More

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http://dx.doi.org/10.1080/01480545.2018.1551406DOI Listing
January 2019
1 Read

Glycyrrhizic acid and silymarin alleviate the neurotoxic effects of aluminum in rats challenged with fructose-induced insulin resistance: possible role of toll-like receptor 4 pathway.

Drug Chem Toxicol 2019 Mar 7;42(2):210-219. Epub 2019 Jan 7.

a Department of Pharmacology, Faculty of Pharmacy , Zagazig University , Zagazig 44519 Egypt.

Aluminum is implicated in the etiology of different neurodegenerative diseases, diabetes and cancer. The current study was conducted to evaluate the protective effects of glycyrrhizic acid (GAM) and silymarin (SLY) on AlCl-induced neurotoxicity in insulin resistant rats. Insulin resistance (IR) was induced by fructose (10%) in drinking water for 18 weeks. Read More

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http://dx.doi.org/10.1080/01480545.2018.1544984DOI Listing
March 2019
3 Reads

β-Phenylethylamine and various monomethylated and para-halogenated analogs. Acute toxicity studies in mice.

Drug Chem Toxicol 2019 Jan 7:1-4. Epub 2019 Jan 7.

c Safety Pharmacology , Collegeville , PA , USA.

Phenylethylamine's acute toxic effects in a population of adult (10 to 12 weeks old; ∼30 g) Swiss male albino mice are significantly increased by para-position aromatic ring halogenation. LD, LD, and LD values (mg/kg; x ± SEM) for p-F- (116.7 ± 3. Read More

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http://dx.doi.org/10.1080/01480545.2018.1551899DOI Listing
January 2019
4 Reads

Studies on oral subacute toxicity of cartap in male mice.

Drug Chem Toxicol 2019 Jan 7:1-9. Epub 2019 Jan 7.

b Toxicology Laboratory, Center for Animal Disease Research and Diagnosis , Indian Veterinary Research Institute , Izatnagar , India.

S-[3-carbamoylsulfanyl-2-(dimethylamino)propyl] carbamothioate (Cartap) (CAS number: 15263-52-2) is a synthetic insecticide of thiocarbamates group that is extensively used in field of agriculture for controlling of several pests like rice stem borer, leaf folder pests in paddy field and diamond back moth, aphids in cabbage and cauliflower crops. Cartap, as a pesticide has not been investigated yet for its effect on vital organs and biochemical stress in vivo and the present study was undertaken to evaluate the same in Swiss albino mice. For this purpose male mice were given three different dose levels of cartap, i. Read More

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http://dx.doi.org/10.1080/01480545.2018.1551900DOI Listing
January 2019
1 Read

Illuminating the cellular and molecular mechanism of the potential toxicity of methacrylate monomers used in biomaterials.

Authors:
Jana Juráňová

Drug Chem Toxicol 2019 Jan 4:1-13. Epub 2019 Jan 4.

a Department of Medical Chemistry and Biochemistry, Faculty of Medicine and Dentistry , Palacky University , Hněvotínská 3 , Olomouc , Czech Republic.

The cytotoxicity of methacrylate-based biopolymers crosslinked by in situ photopolymerization has been attributed mainly to residual methacrylate monomers released due to incomplete polymerization. The residual monomers, primarily triethyleneglycol dimethacrylate or 2-hydroxyethyl methacrylate, may irritate adjacent tissue, or be released into the bloodstream and reach practically all tissues. Increased production of reactive oxygen species, which may be connected to concomitant glutathione depletion, has been the most noticeable effect observed in vitro following the exposure of cells to methacrylates. Read More

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http://dx.doi.org/10.1080/01480545.2018.1488860DOI Listing
January 2019
3 Reads

Genotoxicity of selected pharmaceuticals, their binary mixtures, and varying environmental conditions - study with human adenocarcinoma cancer HT29 cell line.

Drug Chem Toxicol 2019 Jan 4:1-11. Epub 2019 Jan 4.

a Department of Analytical Chemistry, Faculty of Chemistry , Gdansk University of Technology , Gdańsk , Poland.

Pharmaceutical residues are present in the environment in mixtures and their adverse effects may also result from interactions that occur between compounds. Studies presented in this work focus on genotoxicity of pharmaceuticals from different therapeutic groups in mixtures and in individual solutions impacted with different environmental conditions assessed using comet assay (alkaline approach). Binary mixtures of pharmaceuticals (in different concentration ratios) and in individual solutions impacted with pH change (range from 5. Read More

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http://dx.doi.org/10.1080/01480545.2018.1529783DOI Listing
January 2019
2 Reads

Evaluation of toxicological and antimicrobial activity of lavender and immortelle essential oils.

Drug Chem Toxicol 2019 Jan 4:1-8. Epub 2019 Jan 4.

a Department of Biology, Faculty of Science , University of Sarajevo , Sarajevo , Bosnia and Herzegovina.

Lavender and immortelle essential oils (EOs) are widely used to treat a spectrum of human conditions. The aim of this study was to investigate cyto/genotoxic effects of lavender and immortelle EOs using plant cells (Allium cepa) and human lymphocytes, as well as their antimicrobial potential using nine strains of bacteria and fungi. Our results for lavender and immortelle EOs showed that the frequency of chromosome aberrations (CAs) was increased in comparison with controls. Read More

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http://dx.doi.org/10.1080/01480545.2018.1538234DOI Listing
January 2019
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First case of acute respiratory distress syndrome and alimentary tract hemorrhage following mass ingestion of methylisothiazolinone.

Drug Chem Toxicol 2019 May 4;42(3):317-320. Epub 2019 Jan 4.

e Department of Critical Care Medicine , First Afflicted Hospital of Xi'an Jiaotong University , Xi'an , China.

The frequency of methylisothiazolinone (MIT)-related health concerns regarding allergic contact dermatitis with a spongiotic reaction pattern and restrictive lung function indicating peripheral airway dysfunction caused by the use of humidifier disinfectant is increasingly rising. There is a limited number of evidences supporting the environmentally acute and mass exposure to MIT resulting in acute respiratory distress syndrome (ARDS). Here, we report the first case of ARDS and alimentary tract hemorrhage following mass ingestion of methylisothiazolinone. Read More

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http://dx.doi.org/10.1080/01480545.2018.1515217DOI Listing
May 2019
3 Reads
1.098 Impact Factor

Comparison of several commonly used detection indicators of cell senescence.

Drug Chem Toxicol 2018 Dec 27:1-6. Epub 2018 Dec 27.

a Department of Health Toxicology, Xiangya School of Public Health , Central South University , Changsha , PR China.

Cell senescence is the state of irreversible growth arrest that can be triggered by a variety of different cellular stresses. Currently, the commonly used detection indicators involved in the study of cell senescence include senescence-associated β-galactosidase, Clusterin, Telomeres/Telomerase, senescence-associated heterochromatin foci, senescence-associated secretory phenotype, senescence marker protein-30, tumor suppressor genes p53 and p16, and other indicators such as Ki67 and decoy receptor 2. These indicators are widely used in the study of cell senescence, each with its own characteristics, advantages, and disadvantages. Read More

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http://dx.doi.org/10.1080/01480545.2018.1551407DOI Listing
December 2018
2 Reads
1.098 Impact Factor

Protocatechuic acid protects against menadione-induced liver damage by up-regulating nuclear erythroid-related factor 2.

Drug Chem Toxicol 2018 Dec 26:1-7. Epub 2018 Dec 26.

b Antioxidants, Redox Biology and Toxicology Research Laboratory, Department of Medical Biochemistry, College of Health Sciences , Nile University of Nigeria , Abuja , Nigeria.

Menadione (Vitamin K) is an over-the-counter (OTC) drug used in the treatment of abdominal cramps, colitis, diarrhea, hay fever, hemorrahage, hypoprothrombinemia, and joint pains. In this study, we evaluated the protective influence of protocatechuic acid on menadione-induced hepatotoxicity in rats. Rats were randomized into five groups (A-E) of five rats each. Read More

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http://dx.doi.org/10.1080/01480545.2018.1523187DOI Listing
December 2018
2 Reads

Cytotoxicity and antigenotoxicity evaluation of acetylshikonin and shikonin.

Drug Chem Toxicol 2018 Dec 21:1-8. Epub 2018 Dec 21.

a Department of Environmental Health Sciences , Medical University of Warsaw , Poland.

Shikonin (SH) is used as a red pigment for food coloring and cosmetics, and has cytotoxic activity towards cancer cells. However, due to strong toxicity SH has limited potential as an anticancer drug. Acetylshikonin (ASH) is one of the SH derivatives with promising anticancer potential. Read More

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https://www.tandfonline.com/doi/full/10.1080/01480545.2018.1
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http://dx.doi.org/10.1080/01480545.2018.1536710DOI Listing
December 2018
14 Reads

The protective effect of fasudil against acrylamide-induced cytotoxicity in PC12 cells.

Drug Chem Toxicol 2018 Dec 21:1-7. Epub 2018 Dec 21.

a School of Pharmacy , Mashhad University of Medical Sciences , Mashhad , Iran.

Acrylamide (ACR), a vinyl monomer that has multiple chemical and industrial applications, is a neurotoxic agent in human and animal. Fasudil is a potent Rho-kinase inhibitor which exhibits neuroprotective effects in some neuronal degenerative disorders. In this study, the potential protective effect of Fasudil on ACR-induced cytotoxicity in PC12 cells was evaluated. Read More

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http://dx.doi.org/10.1080/01480545.2018.1536140DOI Listing
December 2018
2 Reads

Mercury disrupts redox status, up-regulates metallothionein and induces genotoxicity in respiratory tree of sea cucumber (Holothuria forskali).

Drug Chem Toxicol 2018 Dec 17:1-11. Epub 2018 Dec 17.

a UR: Physiology and Aquatic Environment, Department of Biology, Faculty of Sciences of Tunis , University Tunis El Manar , Tunis , Tunisia.

Mercury (Hg) is among the most deleterious contaminant in the aquatic environment and presents a serious risk to humans and ecosystems. This study evaluated the effects of Hg on oxidative stress biomarkers, DNA integrity and histological structure of the respiratory tree of Holothuria forskali exposed to different concentrations of mercury chloride HgCl (0.04, 0. Read More

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http://dx.doi.org/10.1080/01480545.2018.1524475DOI Listing
December 2018
2 Reads

Protective effect of gastrodin on peripheral neuropathy induced by anti-tumor treatment with vincristine in rat models.

Drug Chem Toxicol 2018 Dec 17:1-8. Epub 2018 Dec 17.

a Third-Grade Pharmacology Laboratory on Traditional Chinese Medicine Approved by State Administration of Traditional Chinese Medicine , Medical Science College of China Three Gorges University , Yichang , PR China.

Cancer is a common disease threatening human health, chemotherapy is widely used in clinical treatment of cancer, but chemotherapy-induced peripheral neuropathy (CIPN) has a relevant impact on life quality of cancer patients. Administration of gastrodin can relieve chronic pain to cancer patients with CIPN and attenuated the inflammatory response by reducing the expression of tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6). However, its exact molecular mechanisms remain unclear. Read More

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http://dx.doi.org/10.1080/01480545.2018.1547739DOI Listing
December 2018
2 Reads

Determination of acyclovir in renal microdialysis fluid and confirmation of renal function index.

Drug Chem Toxicol 2018 Nov 28:1-7. Epub 2018 Nov 28.

a School of Pharmacology , Zhejiang Chinese Medical University , Hangzhou , Zhejiang Province , PR China.

Acyclovir (ACV) is a nucleoside antivirus-free agent that was developed and marketed by Burroughs Well-come of the United States. Renal damage from ACV has been a major factor limiting its clinical application. Thus, the renal toxicity mechanism of ACV requires systematic study. Read More

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https://www.tandfonline.com/doi/full/10.1080/01480545.2018.1
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http://dx.doi.org/10.1080/01480545.2018.1524474DOI Listing
November 2018
17 Reads

Exposure to biomass smoke is associated with an increased expression of circulating miRNA-126 and miRNA-155 in Mexican women: a pilot study.

Drug Chem Toxicol 2019 May 28;42(3):335-342. Epub 2018 Nov 28.

a Laboratorio de Toxicología Molecular, Centro de Investigación Aplicada en Ambiente y Salud (CIAAS) , Coordinación para la Innovación y Aplicación de la Ciencia y la Tecnología (CIACYT), Universidad Autónoma de San Luis Potosí , San Luis Potosí , México.

Household air pollution has been associated as a risk factor for cardiovascular diseases (CVD). Therefore, the aim of this study was to assess the expression of vascular inflammation regulators miR-126 and miR-155 in plasma from women that cook with wood and women that cook with liquid petroleum gas (LPG). A cumulative index of exposure to smoke (CIES) was estimated, urinary 1-hydroxypyrene (1-OHP) levels were quantified and miRNAs expression levels were determined by quantitative real-time PCR (qRT-PCR). Read More

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http://dx.doi.org/10.1080/01480545.2018.1526181DOI Listing
May 2019
1 Read

Chemotherapeutic and prophylactic antimalarial drugs induce cell death through mitochondrial-mediated apoptosis in murine models.

Drug Chem Toxicol 2018 Nov 28:1-11. Epub 2018 Nov 28.

a Laboratories for Biomembrane Research and Biotechnology, Department of Biochemistry, Faculty of Basic Medical Sciences, College of Medicine , University of Ibadan, Ibadan , Nigeria.

Malaria is a parasitic disease that has defied many treatment plans. This study was carried out to investigate the host mitochondrial response to malarial infection and selected antimalarial chemotherapy using murine models. The effects of artesunate (ART) and proguanil (PRG) on mitochondrial Permeability Transition (mPT), mitochondrial ATPase (mATPase), level of malondialdehyde (MDA) and activities of antioxidant enzymes; catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GPx), Xanthine oxidase (XO), glutathione S-transferase (GST) and reduced glutathione (GSH) were estimated in Plasmodium berghei-infected mice treated with ART and PRG. Read More

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http://dx.doi.org/10.1080/01480545.2018.1536139DOI Listing
November 2018
4 Reads