1,714 results match your criteria Drug and Chemical Toxicology [Journal]


Bufalin induces apoptosis via mitochondrial ROS-mediated caspase-3 activation in HCT-116 and SW620 human colon cancer cells.

Drug Chem Toxicol 2019 Feb 19:1-7. Epub 2019 Feb 19.

a Institute of Hepatobiliary Surgery, Southwest Hospital , Third Military Medical University (Army Medical University) , Chongqing , China.

Objective: Bufalin has been reported to kill various types of cancer including human colorectal cancer. Our previous study demonstrated that bufalin induced cell death via autophagy in HT-29 and Caco-2 colon cancer cells, but the action of bufalin remains unclear. This study was conducted to investigate the role of bufalin in other colon cancer HCT-116 and SW620 cells as well as its potential mechanism. Read More

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http://dx.doi.org/10.1080/01480545.2018.1512611DOI Listing
February 2019

Evaluation of the anti-oxidant and anti-inflammatory effects of the methanolic extract of Ferula szowitsiana root on PHA-induced inflammation in human lymphocytes.

Drug Chem Toxicol 2019 Feb 14:1-8. Epub 2019 Feb 14.

c Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences , Mashhad , Iran.

Inflammation is defined as a defensive response of the body against either the endogenous or exogenous triggers, while this process becomes chronic leading to various disorders such as asthma, cancers, and multiple sclerosis. Recently, pharmacological properties of different constituents of F. szowitsiana have been reported. Read More

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http://dx.doi.org/10.1080/01480545.2019.1572182DOI Listing
February 2019

Nanoformulations and their mode of action in insects: a review of biological interactions.

Drug Chem Toxicol 2019 Feb 13:1-11. Epub 2019 Feb 13.

a Department of Zoology , Lahore College for Women University , Lahore , Pakistan.

While nanoparticles (NPs) can be used as insecticides by themselves, they can also be carriers for insecticidal chemicals. Existing literature suggests that the smaller the NP size, the greater the toxicity and penetration into the insect's body. Nonetheless, there is a lack of literature pertaining to the mode of action within insects. Read More

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http://dx.doi.org/10.1080/01480545.2018.1525393DOI Listing
February 2019

Neuro-protective potential of quercetin during chlorpyrifos induced neurotoxicity in rats.

Drug Chem Toxicol 2019 Feb 12:1-11. Epub 2019 Feb 12.

a Department of Biophysics , Panjab University , Chandigarh , India.

Chlorpyrifos (CPF) has been considered as one of the most potent organophosphates and is linked to several neurological disorders. On the other hand, Quercetin is a vital plant flavanoid and has been reported to regulate a number of physiological processes in the central nervous system. The present study was conducted to investigate the protective potential of quercetin during chlorpyrifos induced neurotoxicity. Read More

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https://www.tandfonline.com/doi/full/10.1080/01480545.2019.1
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http://dx.doi.org/10.1080/01480545.2019.1569022DOI Listing
February 2019
2 Reads

The protective effect of Zataria multiflora Boiss essential oil on CCl induced liver fibrosis in rats.

Drug Chem Toxicol 2019 Feb 12:1-9. Epub 2019 Feb 12.

c Department of Clinical Studies, School of Veterinary Medicine , Shiraz University , Shiraz , Iran.

Activation of hepatic stellate cells by free radicals is an initial step in the development of liver fibrosis. Zataria multiflora Boiss (ZM) essential oil as a natural product has antioxidant activity and maybe a suitable candidate for treatment or prevention of the disease. Thus, this study aims to evaluate the protective effect of ZM oil in CCl induced liver fibrosis. Read More

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http://dx.doi.org/10.1080/01480545.2019.1571502DOI Listing
February 2019

miR-155 influences cell-mediated immunity in Balb/c mice treated with aflatoxin M.

Drug Chem Toxicol 2019 Feb 11:1-8. Epub 2019 Feb 11.

a Department of Pharmacodynamics and Toxicology, School of Pharmacy , Mashhad University of Medical Sciences , Mashhad , Iran.

Aflatoxin M (AFM) is a 4-hydroxylated metabolite of aflatoxin B (AFB). It induces various toxicological effects including immunotoxicity. In the present study, we investigated the effects of AFM on immune system and its modulation by MicroRNA (miR)-155. Read More

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http://dx.doi.org/10.1080/01480545.2018.1556682DOI Listing
February 2019

Crocin as a novel therapeutic agent against colitis.

Drug Chem Toxicol 2019 Feb 3:1-8. Epub 2019 Feb 3.

a Department of Medical Physiology, Faculty of Medicine , Mashhad University of Medical Sciences , Mashhad , Iran.

Ulcerative colitis is a chronic inflammatory bowel disease with high incidence and prevalence worldwide. To investigate the therapeutic potency of crocin, as a pharmacologically active component of saffron, in dextran sodium sulfate (DSS)-induced colitis mice model. Experimental colitis was induced by 7-day administration of DSS dissolved in water at a concentration of 1. Read More

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http://dx.doi.org/10.1080/01480545.2018.1527850DOI Listing
February 2019
3 Reads

Protective effect of aminoguanidine against lipopolysaccharide-induced hepatotoxicity and liver dysfunction in rat.

Drug Chem Toxicol 2019 Jan 29:1-7. Epub 2019 Jan 29.

e Department of Physiology , School of Medicine, Jiroft University of Medical Sciences , Jiroft , Iran.

Lipopolysaccharide (LPS) as the major component of the outer membrane of Gram-negative bacteria activates macrophages to produce a high level of pro-inflammatory cytokines which is considered as a cause of liver dysfunction. Overproduction of nitric oxide (NO) has been suggested to have a role in hepatic injury. The aim of the present study was to explore the protective effects of aminoguanidine (AG) as inducible nitric oxide synthase (iNOS) inhibitor against LPS -induced liver dysfunction in rat. Read More

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http://dx.doi.org/10.1080/01480545.2018.1561712DOI Listing
January 2019
1 Read

Anti-hyperglycemic and genotoxic studies of 1-O-methyl chrysophanol, a new anthraquinone isolated from Amycolatopsis thermoflava strain SFMA-103.

Drug Chem Toxicol 2019 Jan 7:1-13. Epub 2019 Jan 7.

a Medicinal Chemistry and Biotechnology Division , CSIR-Indian Institute of Chemical Technology , Hyderabad , India.

The compound 1-O-methyl chrysophanol (OMC) which belongs to a class of hydroxyanthraquinones was isolated from Amycolatopsis thermoflava strain SFMA-103 and studied for their anti-diabetic properties. OMC was evaluated as an anti-diabetic agent based on in silico studies which initially predicted the binding energy with α-amylase (-188.81 KJ mol) and with α-glucosidase (70. Read More

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http://dx.doi.org/10.1080/01480545.2018.1551406DOI Listing
January 2019
1 Read

Glycyrrhizic acid and silymarin alleviate the neurotoxic effects of aluminum in rats challenged with fructose-induced insulin resistance: possible role of toll-like receptor 4 pathway.

Drug Chem Toxicol 2019 Jan 7:1-10. Epub 2019 Jan 7.

a Department of Pharmacology, Faculty of Pharmacy , Zagazig University , Zagazig 44519 Egypt.

Aluminum is implicated in the etiology of different neurodegenerative diseases, diabetes and cancer. The current study was conducted to evaluate the protective effects of glycyrrhizic acid (GAM) and silymarin (SLY) on AlCl-induced neurotoxicity in insulin resistant rats. Insulin resistance (IR) was induced by fructose (10%) in drinking water for 18 weeks. Read More

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http://dx.doi.org/10.1080/01480545.2018.1544984DOI Listing
January 2019
3 Reads

β-Phenylethylamine and various monomethylated and para-halogenated analogs. Acute toxicity studies in mice.

Drug Chem Toxicol 2019 Jan 7:1-4. Epub 2019 Jan 7.

c Safety Pharmacology , Collegeville , PA , USA.

Phenylethylamine's acute toxic effects in a population of adult (10 to 12 weeks old; ∼30 g) Swiss male albino mice are significantly increased by para-position aromatic ring halogenation. LD, LD, and LD values (mg/kg; x ± SEM) for p-F- (116.7 ± 3. Read More

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http://dx.doi.org/10.1080/01480545.2018.1551899DOI Listing
January 2019
2 Reads

Studies on oral subacute toxicity of cartap in male mice.

Drug Chem Toxicol 2019 Jan 7:1-9. Epub 2019 Jan 7.

b Toxicology Laboratory, Center for Animal Disease Research and Diagnosis , Indian Veterinary Research Institute , Izatnagar , India.

S-[3-carbamoylsulfanyl-2-(dimethylamino)propyl] carbamothioate (Cartap) (CAS number: 15263-52-2) is a synthetic insecticide of thiocarbamates group that is extensively used in field of agriculture for controlling of several pests like rice stem borer, leaf folder pests in paddy field and diamond back moth, aphids in cabbage and cauliflower crops. Cartap, as a pesticide has not been investigated yet for its effect on vital organs and biochemical stress in vivo and the present study was undertaken to evaluate the same in Swiss albino mice. For this purpose male mice were given three different dose levels of cartap, i. Read More

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http://dx.doi.org/10.1080/01480545.2018.1551900DOI Listing
January 2019
1 Read

Illuminating the cellular and molecular mechanism of the potential toxicity of methacrylate monomers used in biomaterials.

Authors:
Jana Juráňová

Drug Chem Toxicol 2019 Jan 4:1-13. Epub 2019 Jan 4.

a Department of Medical Chemistry and Biochemistry, Faculty of Medicine and Dentistry , Palacky University , Hněvotínská 3 , Olomouc , Czech Republic.

The cytotoxicity of methacrylate-based biopolymers crosslinked by in situ photopolymerization has been attributed mainly to residual methacrylate monomers released due to incomplete polymerization. The residual monomers, primarily triethyleneglycol dimethacrylate or 2-hydroxyethyl methacrylate, may irritate adjacent tissue, or be released into the bloodstream and reach practically all tissues. Increased production of reactive oxygen species, which may be connected to concomitant glutathione depletion, has been the most noticeable effect observed in vitro following the exposure of cells to methacrylates. Read More

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http://dx.doi.org/10.1080/01480545.2018.1488860DOI Listing
January 2019
3 Reads

Genotoxicity of selected pharmaceuticals, their binary mixtures, and varying environmental conditions - study with human adenocarcinoma cancer HT29 cell line.

Drug Chem Toxicol 2019 Jan 4:1-11. Epub 2019 Jan 4.

a Department of Analytical Chemistry, Faculty of Chemistry , Gdansk University of Technology , Gdańsk , Poland.

Pharmaceutical residues are present in the environment in mixtures and their adverse effects may also result from interactions that occur between compounds. Studies presented in this work focus on genotoxicity of pharmaceuticals from different therapeutic groups in mixtures and in individual solutions impacted with different environmental conditions assessed using comet assay (alkaline approach). Binary mixtures of pharmaceuticals (in different concentration ratios) and in individual solutions impacted with pH change (range from 5. Read More

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http://dx.doi.org/10.1080/01480545.2018.1529783DOI Listing
January 2019
1 Read

Evaluation of toxicological and antimicrobial activity of lavender and immortelle essential oils.

Drug Chem Toxicol 2019 Jan 4:1-8. Epub 2019 Jan 4.

a Department of Biology, Faculty of Science , University of Sarajevo , Sarajevo , Bosnia and Herzegovina.

Lavender and immortelle essential oils (EOs) are widely used to treat a spectrum of human conditions. The aim of this study was to investigate cyto/genotoxic effects of lavender and immortelle EOs using plant cells (Allium cepa) and human lymphocytes, as well as their antimicrobial potential using nine strains of bacteria and fungi. Our results for lavender and immortelle EOs showed that the frequency of chromosome aberrations (CAs) was increased in comparison with controls. Read More

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http://dx.doi.org/10.1080/01480545.2018.1538234DOI Listing
January 2019
1 Read

First case of acute respiratory distress syndrome and alimentary tract hemorrhage following mass ingestion of methylisothiazolinone.

Drug Chem Toxicol 2019 Jan 4:1-4. Epub 2019 Jan 4.

e Department of Critical Care Medicine , First Afflicted Hospital of Xi'an Jiaotong University , Xi'an , China.

The frequency of methylisothiazolinone (MIT)-related health concerns regarding allergic contact dermatitis with a spongiotic reaction pattern and restrictive lung function indicating peripheral airway dysfunction caused by the use of humidifier disinfectant is increasingly rising. There is a limited number of evidences supporting the environmentally acute and mass exposure to MIT resulting in acute respiratory distress syndrome (ARDS). Here, we report the first case of ARDS and alimentary tract hemorrhage following mass ingestion of methylisothiazolinone. Read More

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http://dx.doi.org/10.1080/01480545.2018.1515217DOI Listing
January 2019
2 Reads
1.098 Impact Factor

Comparison of several commonly used detection indicators of cell senescence.

Drug Chem Toxicol 2018 Dec 27:1-6. Epub 2018 Dec 27.

a Department of Health Toxicology, Xiangya School of Public Health , Central South University , Changsha , PR China.

Cell senescence is the state of irreversible growth arrest that can be triggered by a variety of different cellular stresses. Currently, the commonly used detection indicators involved in the study of cell senescence include senescence-associated β-galactosidase, Clusterin, Telomeres/Telomerase, senescence-associated heterochromatin foci, senescence-associated secretory phenotype, senescence marker protein-30, tumor suppressor genes p53 and p16, and other indicators such as Ki67 and decoy receptor 2. These indicators are widely used in the study of cell senescence, each with its own characteristics, advantages, and disadvantages. Read More

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http://dx.doi.org/10.1080/01480545.2018.1551407DOI Listing
December 2018
2 Reads
1.098 Impact Factor

Protocatechuic acid protects against menadione-induced liver damage by up-regulating nuclear erythroid-related factor 2.

Drug Chem Toxicol 2018 Dec 26:1-7. Epub 2018 Dec 26.

b Antioxidants, Redox Biology and Toxicology Research Laboratory, Department of Medical Biochemistry, College of Health Sciences , Nile University of Nigeria , Abuja , Nigeria.

Menadione (Vitamin K) is an over-the-counter (OTC) drug used in the treatment of abdominal cramps, colitis, diarrhea, hay fever, hemorrahage, hypoprothrombinemia, and joint pains. In this study, we evaluated the protective influence of protocatechuic acid on menadione-induced hepatotoxicity in rats. Rats were randomized into five groups (A-E) of five rats each. Read More

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http://dx.doi.org/10.1080/01480545.2018.1523187DOI Listing
December 2018
1 Read

Cytotoxicity and antigenotoxicity evaluation of acetylshikonin and shikonin.

Drug Chem Toxicol 2018 Dec 21:1-8. Epub 2018 Dec 21.

a Department of Environmental Health Sciences , Medical University of Warsaw , Poland.

Shikonin (SH) is used as a red pigment for food coloring and cosmetics, and has cytotoxic activity towards cancer cells. However, due to strong toxicity SH has limited potential as an anticancer drug. Acetylshikonin (ASH) is one of the SH derivatives with promising anticancer potential. Read More

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https://www.tandfonline.com/doi/full/10.1080/01480545.2018.1
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http://dx.doi.org/10.1080/01480545.2018.1536710DOI Listing
December 2018
7 Reads

The protective effect of fasudil against acrylamide-induced cytotoxicity in PC12 cells.

Drug Chem Toxicol 2018 Dec 21:1-7. Epub 2018 Dec 21.

a School of Pharmacy , Mashhad University of Medical Sciences , Mashhad , Iran.

Acrylamide (ACR), a vinyl monomer that has multiple chemical and industrial applications, is a neurotoxic agent in human and animal. Fasudil is a potent Rho-kinase inhibitor which exhibits neuroprotective effects in some neuronal degenerative disorders. In this study, the potential protective effect of Fasudil on ACR-induced cytotoxicity in PC12 cells was evaluated. Read More

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http://dx.doi.org/10.1080/01480545.2018.1536140DOI Listing
December 2018
2 Reads

Mercury disrupts redox status, up-regulates metallothionein and induces genotoxicity in respiratory tree of sea cucumber (Holothuria forskali).

Drug Chem Toxicol 2018 Dec 17:1-11. Epub 2018 Dec 17.

a UR: Physiology and Aquatic Environment, Department of Biology, Faculty of Sciences of Tunis , University Tunis El Manar , Tunis , Tunisia.

Mercury (Hg) is among the most deleterious contaminant in the aquatic environment and presents a serious risk to humans and ecosystems. This study evaluated the effects of Hg on oxidative stress biomarkers, DNA integrity and histological structure of the respiratory tree of Holothuria forskali exposed to different concentrations of mercury chloride HgCl (0.04, 0. Read More

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http://dx.doi.org/10.1080/01480545.2018.1524475DOI Listing
December 2018
1 Read

Protective effect of gastrodin on peripheral neuropathy induced by anti-tumor treatment with vincristine in rat models.

Drug Chem Toxicol 2018 Dec 17:1-8. Epub 2018 Dec 17.

a Third-Grade Pharmacology Laboratory on Traditional Chinese Medicine Approved by State Administration of Traditional Chinese Medicine , Medical Science College of China Three Gorges University , Yichang , PR China.

Cancer is a common disease threatening human health, chemotherapy is widely used in clinical treatment of cancer, but chemotherapy-induced peripheral neuropathy (CIPN) has a relevant impact on life quality of cancer patients. Administration of gastrodin can relieve chronic pain to cancer patients with CIPN and attenuated the inflammatory response by reducing the expression of tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6). However, its exact molecular mechanisms remain unclear. Read More

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http://dx.doi.org/10.1080/01480545.2018.1547739DOI Listing
December 2018
2 Reads

Determination of acyclovir in renal microdialysis fluid and confirmation of renal function index.

Drug Chem Toxicol 2018 Nov 28:1-7. Epub 2018 Nov 28.

a School of Pharmacology , Zhejiang Chinese Medical University , Hangzhou , Zhejiang Province , PR China.

Acyclovir (ACV) is a nucleoside antivirus-free agent that was developed and marketed by Burroughs Well-come of the United States. Renal damage from ACV has been a major factor limiting its clinical application. Thus, the renal toxicity mechanism of ACV requires systematic study. Read More

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https://www.tandfonline.com/doi/full/10.1080/01480545.2018.1
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http://dx.doi.org/10.1080/01480545.2018.1524474DOI Listing
November 2018
10 Reads

Exposure to biomass smoke is associated with an increased expression of circulating miRNA-126 and miRNA-155 in Mexican women: a pilot study.

Drug Chem Toxicol 2018 Nov 28:1-8. Epub 2018 Nov 28.

a Laboratorio de Toxicología Molecular, Centro de Investigación Aplicada en Ambiente y Salud (CIAAS) , Coordinación para la Innovación y Aplicación de la Ciencia y la Tecnología (CIACYT), Universidad Autónoma de San Luis Potosí , San Luis Potosí , México.

Household air pollution has been associated as a risk factor for cardiovascular diseases (CVD). Therefore, the aim of this study was to assess the expression of vascular inflammation regulators miR-126 and miR-155 in plasma from women that cook with wood and women that cook with liquid petroleum gas (LPG). A cumulative index of exposure to smoke (CIES) was estimated, urinary 1-hydroxypyrene (1-OHP) levels were quantified and miRNAs expression levels were determined by quantitative real-time PCR (qRT-PCR). Read More

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http://dx.doi.org/10.1080/01480545.2018.1526181DOI Listing
November 2018
1 Read

Chemotherapeutic and prophylactic antimalarial drugs induce cell death through mitochondrial-mediated apoptosis in murine models.

Drug Chem Toxicol 2018 Nov 28:1-11. Epub 2018 Nov 28.

a Laboratories for Biomembrane Research and Biotechnology, Department of Biochemistry, Faculty of Basic Medical Sciences, College of Medicine , University of Ibadan, Ibadan , Nigeria.

Malaria is a parasitic disease that has defied many treatment plans. This study was carried out to investigate the host mitochondrial response to malarial infection and selected antimalarial chemotherapy using murine models. The effects of artesunate (ART) and proguanil (PRG) on mitochondrial Permeability Transition (mPT), mitochondrial ATPase (mATPase), level of malondialdehyde (MDA) and activities of antioxidant enzymes; catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GPx), Xanthine oxidase (XO), glutathione S-transferase (GST) and reduced glutathione (GSH) were estimated in Plasmodium berghei-infected mice treated with ART and PRG. Read More

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http://dx.doi.org/10.1080/01480545.2018.1536139DOI Listing
November 2018
4 Reads

Effect of sub-toxic exposure to Malathion on glucose uptake and insulin signaling in L6 myoblast derived myotubes.

Drug Chem Toxicol 2018 Nov 29:1-8. Epub 2018 Nov 29.

a Department of Biochemistry , Maulana Azad Medical College , New Delhi , India.

Biochemical basis of Malathion exposure-induced diabetes mellitus is not known. Hence, effects of its sub-toxic exposure on redox sensitive kinases (RSKs), insulin signaling and insulin-induced glucose uptake were assessed in rat muscle cell line. In this in vitro study, rat myoblast (L6) cells were differentiated to myotubes and were exposed to sub-toxic concentrations (10 mg/l and 20 mg/l) of Malathion for 18 hours. Read More

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http://dx.doi.org/10.1080/01480545.2018.1531881DOI Listing
November 2018
1 Read

Safety and tolerability of carvacrol in healthy subjects: a phase I clinical study.

Drug Chem Toxicol 2018 Nov 29:1-12. Epub 2018 Nov 29.

b Department of Physiology , School of Medicine, Mashhad University of Medical Sciences , Mashhad , Iran.

This study was designed to assess safety and tolerability of carvacrol in healthy individuals. Subjects were randomly divided into two groups receiving 1 and 2 mg/kg/day carvacrol. Before and after carvacrol administration, routine blood and urine laboratory tests and spirometry were performed for all participants. Read More

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https://www.tandfonline.com/doi/full/10.1080/01480545.2018.1
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http://dx.doi.org/10.1080/01480545.2018.1538233DOI Listing
November 2018
9 Reads

Potential of curcumin and resveratrol as biochemical and biophysical modulators during lung cancer in rats.

Drug Chem Toxicol 2018 Nov 28:1-7. Epub 2018 Nov 28.

a Department of Respiratory Medicine Laboratory , Dezhou People's Hospital , Dezhou, China.

The present study explored chemopreventive aspects of curcumin and resveratrol in the experimental model of lung carcinogenesis in rats. The main aim was to establish efficacy of combined phytochemicals treatment over individual treatments in rat cancer model. The study was performed in terms of both biophysical and biochemical parameters. Read More

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https://www.tandfonline.com/doi/full/10.1080/01480545.2018.1
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http://dx.doi.org/10.1080/01480545.2018.1523921DOI Listing
November 2018
3 Reads

Characterization and toxicology evaluation of zirconium oxide nanoparticles on the embryonic development of zebrafish, Danio rerio.

Drug Chem Toxicol 2019 Jan 20;42(1):104-111. Epub 2018 Nov 20.

d Department of Pharmacology , Saveetha Dental College and Hospitals, SIMATS , Chennai , TN , India.

Zirconia oxide nanoparticles (ZrONPs) are known to be one of the neutral bioceramic metal compounds that has been widely used for their beneficial applications in many biomedical areas, in dental implants, bone joint replacements, drug delivery vehicles, and in various industrial applications. To study the effects of ZrONPs on zebrafish model, we used early life stages of the zebrafish (Danio rerio) to examine such effects on embryonic development in this species. ZrONPs were synthesized by the sol-gel method, size about 15-20 nm and characterized by SEM, EDX, XRD, FTIR, UV-Vis Spectra. Read More

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http://dx.doi.org/10.1080/01480545.2018.1523186DOI Listing
January 2019
15 Reads

Neurophysiological responses in the brain tissues of rainbow trout (Oncorhynchus mykiss) treated with bio-pesticide.

Drug Chem Toxicol 2018 Nov 19:1-7. Epub 2018 Nov 19.

a Department of Aquaculture , Faculty of Fisheries, Ataturk University , Erzurum , Turkey.

The aim of this study was to investigate neurophysiological responses in rainbow trout brain tissue exposed to natural/botanical pesticides. Fish were exposed to botanical and synthetic pesticides over a 21-day period. At the end of the treatment period, oxidative DNA damage (indicated by 8-OHdG (8-hydroxy-2'-deoxyguanosine), AChE activity (acetylcholinesterase) and transcriptional parameters (gpx (glutathione peroxidase), sod (superoxide dismutase), cat (catalase), HSP70 (heat shock protein 70) and CYP1A (cytochromes P450)) was investigated in control and application groups. Read More

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http://dx.doi.org/10.1080/01480545.2018.1526180DOI Listing
November 2018
4 Reads

Short-term exposure to titanium, aluminum and niobium (Ti-6Al-4Nb) alloy powder can disturb the serum low-density lipoprotein concentrations and antioxidant profile in vital organs but not the behavior of male albino mice.

Drug Chem Toxicol 2018 Nov 19:1-9. Epub 2018 Nov 19.

b Institute of Pure and Applied Biology, Zoology Division , Bahauddin Zakariya University , Multan , Pakistan.

A group of seven-week-old albino mice of both genders were orally administered with a suspension of 25 mg Ti-6Al-4Nb/ml of saline/kg body weight and evaluated in comparison with a control group of animals treated with saline. Evaluation of both the groups was conducted through behavioral tests (Rota rod, open field, novel object and light dark box test), blood biochemical tests [complete blood count and selected serum parameters ([cholesterol, high-density lipoproteins, low-density lipoproteins, creatinine and triglycerides)] and on the basis of measured concentration of antioxidant metabolites (superoxide dismutase, catalase and lipid peroxidation) in vital organs (brain, heart, liver, kidney and lungs). Based upon the results of these tests, it has been found that the applied dose of Ti-6Al-4Nb alloy powder has not effect on physical and neurological outcome of these animals. Read More

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https://www.tandfonline.com/doi/full/10.1080/01480545.2018.1
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http://dx.doi.org/10.1080/01480545.2018.1525394DOI Listing
November 2018
14 Reads

Gastroprotective effects of oleuropein and thymol on indomethacin-induced gastric ulcer in Sprague-Dawley rats.

Drug Chem Toxicol 2018 Nov 14:1-13. Epub 2018 Nov 14.

a Department of Biology, Faculty of Science , Ataturk University , Erzurum , Turkey.

Ethnopharmacological studies demonstrated that thymol (Thym) and oleuropein (Ole) have therapeutic potential for gastric ulcers. The molecular mechanism underlying the gastroprotective effects of these compounds have not been elucidated yet especially for their individual and combination use at high dose. Therefore, this study was conducted to explore their gastroprotective mechanisms on indomethacin (Indo)-induced gastric ulcer model. Read More

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https://www.tandfonline.com/doi/full/10.1080/01480545.2018.1
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http://dx.doi.org/10.1080/01480545.2018.1530261DOI Listing
November 2018
19 Reads

Effect of endosulfan and bisphenol A on the expression of SUMO and UBC9.

Drug Chem Toxicol 2018 Nov 14:1-8. Epub 2018 Nov 14.

a Department of Biotechnology , BMS College of Engineering , Bengaluru , India.

This study was designed to investigate possible interference of Xenobiotics with SUMOylation in eukaryotic cells. To begin with, we docked 71 chemical structures from PubChem with human SUMO1 and UBC9 protein structures using Auto Dock 4.2 and Hex 6. Read More

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https://www.tandfonline.com/doi/full/10.1080/01480545.2018.1
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http://dx.doi.org/10.1080/01480545.2018.1526179DOI Listing
November 2018
13 Reads

Methyl isocyanate inhalation induces tissue factor-dependent activation of coagulation in rats.

Drug Chem Toxicol 2018 Nov 14:1-7. Epub 2018 Nov 14.

b Department of Pediatrics , University of Colorado , Denver , CO , USA.

Methyl isocyanate (MIC) is a highly toxic industrial chemical causing acute lethality after inhalation. The objective of this study was to determine whether alterations in hemostasis also occur in the immediate hours after exposure. Male rats were exposed to MIC (125-500 ppm) by nose-only vapor inhalation for 30 min. Read More

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https://www.tandfonline.com/doi/full/10.1080/01480545.2018.1
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http://dx.doi.org/10.1080/01480545.2018.1517773DOI Listing
November 2018
12 Reads

Protective effects of Bidens pilosa on hepatoxicity and nephrotoxicity induced by carbon tetrachloride in rats.

Drug Chem Toxicol 2018 Nov 5:1-11. Epub 2018 Nov 5.

e Faculty of Pharmacy , University of Western São Paulo (UNOESTE) , Presidente Prudente , SP , Brazil.

The aim of this study was to assess the protective effects of oral and topical treatment with Bidens pilosa (BP) against carbon tetrachloride (CCl) induced toxicity. Fifty-six rats were divided into seven groups: A: CCl only; B: CCl+oral BP; C: CCl and topical BP; D: CCl+oral and topical BP; E: oral BP only; F: negative control; and G: positive control (cyclophosphamide). The animals were treated for 10 weeks. Read More

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https://www.tandfonline.com/doi/full/10.1080/01480545.2018.1
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http://dx.doi.org/10.1080/01480545.2018.1526182DOI Listing
November 2018
10 Reads

Toxicological and behavioral study of two potential antibacterial agents:4-chloromercuribenzoic acid and quercetin on Swiss-albino mice.

Drug Chem Toxicol 2018 Nov 5:1-11. Epub 2018 Nov 5.

a Department of Biochemistry and Medical Biotechnology , Calcutta School of Tropical Medicine , Kolkata , India.

Global dissemination of carbapenem resistant-Gram negative bacteria (CR-GNB) is supposed to be clinically alarming because it extremely delimits the treatment options against serious infections. 4-Chloromercuribenzoic acid (pCMB) is an efficient metallo-enzyme inhibitor, and quercetin is known for antioxidant, antiviral, anticancer, antimicrobial, and anti-inflammatory activities. These two compounds could be considered as potential candidates for the treatment of CR-GNB mediated infections. Read More

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https://www.tandfonline.com/doi/full/10.1080/01480545.2018.1
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http://dx.doi.org/10.1080/01480545.2018.1517774DOI Listing
November 2018
10 Reads

The cytotoxic and genotoxic effects of daidzein on MIA PaCa-2 human pancreatic carcinoma cells and HT-29 human colon cancer cells.

Drug Chem Toxicol 2018 Nov 5:1-7. Epub 2018 Nov 5.

a Department of Physiology, Faculty of Medicine , Atatürk University , Erzurum , Turkey.

Daidzein (DZ) has anti-inflammatory and antioxidant effects, as well as the dose-dependent inhibition effect on cancer cells. In this study, the cytotoxic and genotoxic effects of DZ on HT-29 (human colorectal adenocarcinoma cells) and MIA PaCa-2 (human pancreatic cancer cells) cell lines were determined using the XTT method and Comet assay, respectively. IC concentrations of DZ were found to be 200 µM in both MIA PaCa-2 and HT-29 cells treated with DZ for 48 hours (h). Read More

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https://www.tandfonline.com/doi/full/10.1080/01480545.2018.1
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http://dx.doi.org/10.1080/01480545.2018.1527849DOI Listing
November 2018
5 Reads

Safety evidence on the administration of Fucus vesiculosus L. (bladderwrack) extract and lamotrigine: data from pharmacokinetic studies in the rat.

Drug Chem Toxicol 2018 Oct 18:1-7. Epub 2018 Oct 18.

a CICS-UBI - Health Sciences Research Centre , University of Beira Interior , Covilhã , Portugal.

Fucus vesiculosus is often incorporated in weight loss dietary supplements to improve weight loss in overweight adults. Obesity is a common condition in epilepsy patients and is indeed increasing in refractory epilepsy and in patients under polytherapy. Since lamotrigine (LTG) is a first-line antiepileptic drug, used in monotherapy or adjunctive therapy, the main objective of this work was to investigate the potential pharmacokinetic-based interactions between F. Read More

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http://dx.doi.org/10.1080/01480545.2018.1518454DOI Listing
October 2018
7 Reads

Butea monosperma (Lam.) Taub. Bark fractions protect against free radicals and induce apoptosis in MCF-7 breast cancer cells via cell-cycle arrest and ROS-mediated pathway.

Drug Chem Toxicol 2018 Oct 8:1-11. Epub 2018 Oct 8.

a Department of Botanical and Environmental Sciences , Guru Nanak Dev University , Amritsar , India.

Butea monosperma (Lam.) Taub. is an ethnomedicinal tree of remedial value in the treatment of diabetes, bone fractures, and liver and neurological disorders. Read More

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https://www.tandfonline.com/doi/full/10.1080/01480545.2018.1
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http://dx.doi.org/10.1080/01480545.2018.1497051DOI Listing
October 2018
3 Reads
1.100 Impact Factor

The mutagenic effect of psychostimulant modafinil in Wistar rats in vivo.

Drug Chem Toxicol 2018 Oct 8:1-5. Epub 2018 Oct 8.

a Department of Biotechnology Genetics and Cell Biology , State University of Maringá , Maringá , Paraná , Brazil.

The demands imposed by today's world require a fast and efficient society, then, significant section of the population looks for support from psychotropic medicine. Modafinil is a psychostimulant that promotes wakefulness, it being recommended for treatment of narcolepsy, obstructive sleep apnea, and shift-work sleep disorder, besides being a cognitive function potentiator. However, chemical components of drugs can alter genetic material. Read More

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https://www.tandfonline.com/doi/full/10.1080/01480545.2018.1
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http://dx.doi.org/10.1080/01480545.2018.1517771DOI Listing
October 2018
18 Reads

ZnO nanoparticles: recent advances in ecotoxicity and risk assessment.

Drug Chem Toxicol 2018 Sep 28:1-12. Epub 2018 Sep 28.

a Institute of Environmental Science and Engineering, College of Materials and Environmental Engineering , Hangzhou Dianzi University , Hangzhou , P.R. China.

The widespread application of zinc oxide nanoparticles (nano-ZnO) has received increasing attention because of their potential risks to human health and the environment. This review summarizes the relationship between the toxic effects and physicochemical properties of nano-ZnO and the underlying toxicity mechanisms of nano-ZnO. This study presents the possible human health hazards posed by nano-ZnO exposure and the biotoxicity to bacteria, algae, higher plants, aquatic animals, terrestrial invertebrates and vertebrates in vitro and in vivo. Read More

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http://dx.doi.org/10.1080/01480545.2018.1508218DOI Listing
September 2018
13 Reads

Protective effect of naringin against BPA-induced cardiotoxicity through prevention of oxidative stress in male Wistar rats.

Drug Chem Toxicol 2018 Sep 28:1-11. Epub 2018 Sep 28.

f Department of Toxicology, School of Pharmacy , Student Research Committee, Ahvaz Jundishapur University of Medical Sciences , Ahvaz , Iran.

Bisphenol A (BPA), which is an applied endocrine disrupting chemical in industry for producing epoxy resins and polycarbonate plastics and naringin, is an active flavanone glycoside of grapefruit and many citrus fruits. The present study evaluated the protective effect of naringin against cardiotoxicity induced by BPA. Male Wistar rats were divided into six groups. Read More

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http://dx.doi.org/10.1080/01480545.2018.1504958DOI Listing
September 2018
8 Reads

Effect of curcumin nanoparticles on the cisplatin-induced neurotoxicity in rat.

Drug Chem Toxicol 2018 Sep 27:1-9. Epub 2018 Sep 27.

a Medical Physiology Department , National Research Centre , Giza , Egypt.

The present study is conducted to evaluate the neuroprotective effect of curcumin nanoparticles (CUR NP) against the neurotoxicity induced by cisplatin (CP) in rat. Rats were divided into control group that received saline solution, CP-treated rats that received a single i.p. Read More

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https://www.tandfonline.com/doi/full/10.1080/01480545.2018.1
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http://dx.doi.org/10.1080/01480545.2018.1504058DOI Listing
September 2018
10 Reads

Evaluation of genotoxic potential of tert-butylquinone and its derivatives in prokaryotic and eukaryotic test models.

Drug Chem Toxicol 2018 Sep 27:1-9. Epub 2018 Sep 27.

a Faculty of Biology, Center for Genotoxicology and Ecogenotoxicology , University of Belgrade , Belgrade , Serbia.

Tert-butylquinone (TBQ) and its alkylamino and aralkylamino derivatives are of high interest as a potential antitumor agent. Therefore, it was necessary to investigate if the compounds exert undesirable activities such as interaction with DNA molecule which could result in negative side effects in the case of their use in the diseases treatment. The major aim of this study was to investigate genotoxic potential of TBQ and selected derivatives in an acellular model by using plasmid DNA, in the prokaryotic model by the SOS/umuC assay in Salmonella typhimurium TA1535/pSK1002 and in eukaryotic models by using comet assay in human fetal lung cell line (MRC-5) and human liver cancer cell line (HepG2). Read More

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http://dx.doi.org/10.1080/01480545.2018.1514043DOI Listing
September 2018
18 Reads

Pefloxacin induced changes in serotonergic innervation and mast cell number in rat salivary glands.

Drug Chem Toxicol 2018 Sep 27:1-8. Epub 2018 Sep 27.

e Faculty of Medicine, Department of Anatomy, Histology and Embryology , University of Debrecen , Debrecen , Hungary.

Pefloxacin is a second-generation fluoroquinolone antibiotic. Besides its advantageous characteristics, side effects including the hypofunction of salivary glands, decreased saliva production, and peripheral neuropathy were observed during the administration of pefloxacin. The aim of this study was to investigate the changes in the number of serotonergic immunoreactive fibers and mast cells after pefloxacin treatment in the parotid and sublingual glands of rats to detect the possible neurotoxic effect of pefloxacin. Read More

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http://dx.doi.org/10.1080/01480545.2018.1508217DOI Listing
September 2018
1 Read

Environmental toxic metals in placenta and their effects on preterm delivery-current opinion.

Drug Chem Toxicol 2018 Sep 27:1-8. Epub 2018 Sep 27.

a Department of Chemistry , Dr. B. R. Ambedkar University, Khandari Campus , Agra , India.

Preterm birth is a significant public reproductive health concern globally; Furthermore, preterm birth has long-lasting medical and pecuniary burdens on the society. Moreover, preterm birth is well-established as the underlying cause of low birth weight in infants as well as neonatal mortality. A growing body of literature suggests that the etiology of preterm delivery in women is elusive; however, countless environmental factors are considered responsible for preterm birth. Read More

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https://www.tandfonline.com/doi/full/10.1080/01480545.2018.1
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http://dx.doi.org/10.1080/01480545.2018.1515216DOI Listing
September 2018
11 Reads

Potential protective effects of naringenin against vancomycin-induced nephrotoxicity via reduction on apoptotic and oxidative stress markers in rats.

Drug Chem Toxicol 2018 Sep 27:1-8. Epub 2018 Sep 27.

e Department of Histology and Embryology , Mersin University , Mersin , Turkey.

Vancomycin (VCM), a glycopeptide antibiotic, is a drug widely used in severe infections. However, VCM induce notable nephrotoxic side effects. Naringenin (NAR) is a natural of flavonoid and are known as strongly antioxidant, nefroprotective, antiapoptotic, and anti-inflammatory. Read More

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https://www.tandfonline.com/doi/full/10.1080/01480545.2018.1
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http://dx.doi.org/10.1080/01480545.2018.1512612DOI Listing
September 2018
4 Reads

Protective effects of ethyl acetate extracts of Rimulus Cinnamon on systemic inflammation and lung injury in endotoxin-poisoned mice.

Drug Chem Toxicol 2018 Sep 27:1-8. Epub 2018 Sep 27.

a Department of Pharmacology, College of Pharmacy , Chengdu University of TCM , Chengdu , Sichuan , P.R. China.

Rimulus cinnamon is the dried twig of Cinnamomum cassia Presl. It is widely used in China for the treatment of inflammatory processes, amenorrhea, and other diseases. We aimed to study the protective effects of ethyl acetate extracts of R. Read More

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http://dx.doi.org/10.1080/01480545.2018.1509987DOI Listing
September 2018
7 Reads
1.100 Impact Factor

Ebselen oxide attenuates mechlorethamine dermatotoxicity in the mouse ear vesicant model.

Drug Chem Toxicol 2018 Sep 26:1-12. Epub 2018 Sep 26.

a Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences , St. John's University , Jamaica , NY , USA.

Mechlorethamine (HN2) is an alkylating agent and sulfur mustard mimetic. Topical exposure to HN2 is associated with tissue blistering. Previous work in our laboratory has shown that ebselen (EB-1) possesses anti-vesicant, anti-inflammatory, anti-bacterial, anti-fungal, and cytoprotective properties, both in vivo and in vitro. Read More

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https://www.tandfonline.com/doi/full/10.1080/01480545.2018.1
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http://dx.doi.org/10.1080/01480545.2018.1488858DOI Listing
September 2018
15 Reads

Comparative toxicity of selected PAHs in rainbow trout hepatocytes: genotoxicity, oxidative stress and cytotoxicity.

Authors:
Mazyar Yazdani

Drug Chem Toxicol 2018 Sep 24:1-8. Epub 2018 Sep 24.

a Department of Medical Biochemistry , Oslo University Hospital, Ullevål , Oslo , Norway.

Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous contaminants in aquatic ecosystems, which may have potentially toxic effects on organisms. In this study occurrence of DNA strand breaks, oxidative stress, and cytotoxicity were investigated in rainbow trout hepatocytes following in vitro exposure for 24 h to four PAHs (0.01-10 µM): naphthalene, fluoranthene, pyrene, and benzo[a]pyrene (B[a]P). Read More

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http://dx.doi.org/10.1080/01480545.2018.1497054DOI Listing
September 2018
15 Reads
1.100 Impact Factor