66 results match your criteria Drug Target Insights [Journal]


DRESS Syndrome and Daclizumab Failure-Were Potentially Dangerous Signs Missed in Clinical Trials?

Drug Target Insights 2018 29;12:1177392818785136. Epub 2018 Jun 29.

Department of Internal Medicine/Division of Neurology, School of Medicine, University of South Carolina, Greenville, SC, USA.

The US Food and Drug Administration (FDA) approved Zinbryta, an interleukin-2 receptor blocking antibody (daclizumab; Biogen and AbbVie) for the treatment of adults with relapsing forms of multiple sclerosis (MS) in May, 2016. It was also approved by the European Union in July, 2016. Zinbryta is a long-acting, self-administered monthly injection that was branded as a new MS drug for patients who needed a "new option for treatment. Read More

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http://dx.doi.org/10.1177/1177392818785136DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6043933PMC
June 2018
3 Reads

Valacyclovir Neurotoxicity and Nephrotoxicity in an Elderly Patient Complicated by Hyponatremia.

Drug Target Insights 2018 25;12:1177392818782899. Epub 2018 Jun 25.

Division of Nephrology, Department of Internal Medicine, Jichi Medical University, Shimotsuke, Japan.

A 66-year-old women with no history of renal disease was admitted due to a coma and acute kidney injury with a serum creatinine level of 7.44 mg/dL which were ascribed to valacyclovir neurotoxicity and nephrotoxicity, respectively. She had received valacyclovir at a standard dosage for the treatment of herpes zoster and was finally discharged, having fully returned to her normal baseline mental status with a recovered serum creatinine level of 0. Read More

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http://dx.doi.org/10.1177/1177392818782899DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6043912PMC
June 2018
31 Reads

Anti-CD20 Cell Therapies in Multiple Sclerosis-A Fixed Dosing Schedule for Ocrelizumab is Overkill.

Drug Target Insights 2017 25;11:1177392817737515. Epub 2017 Oct 25.

Department of Medicine, Division of Neurology, USC School of Medicine Greenville, Greenville, SC, USA.

Anti-CD 20 therapies have found significant uses in multiple sclerosis (MS). Based singularly on the accumulated evidence with the use of rituximab (RTX; Rituxan, Genentech, and Biogen) in neuroimmunological diseases, ocrelizumab (OCR; Ocrevus, Genentech) was developed as a treatment option for MS and selectively targets CD20 B cells, a cell surface antigen found on pre-B cells, mature, and memory B cells, but not on lymphoid stem cells and plasma cells. On the basis of indirect evidence, elimination of the antigen-presenting capabilities and antigen nonspecific immune functions of B cells appear to be central to the therapeutic efficacy of anti-CD20 B-cell therapies. Read More

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http://journals.sagepub.com/doi/10.1177/1177392817737515
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http://dx.doi.org/10.1177/1177392817737515DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5661702PMC
October 2017
13 Reads

Ethanol Extract of Stem Bark Show Remarkable Prophylactic Activity in Experimental -Infected Mice.

Drug Target Insights 2017 28;11:1177392817728725. Epub 2017 Aug 28.

Department of Medical Microbiology & Parasitology, Ladoke Akintola University of Technology, Osogbo, Nigeria.

This work explores the antiplasmodial potential of ethanol extract of (Lin. Sapindaceae) in chloroquine (CQ)-resistant (ANKA strain)-infected mice. Chloroquine-resistant (ANKA) strain of was inoculated intraperitoneally into Swiss albino mice. Read More

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http://dx.doi.org/10.1177/1177392817728725DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5576538PMC
August 2017
7 Reads

Modification of -Adenosyl-l-Homocysteine as Inhibitor of Nonstructural Protein 5 Methyltransferase Dengue Virus Through Molecular Docking and Molecular Dynamics Simulation.

Drug Target Insights 2017 20;11:1177392817701726. Epub 2017 Apr 20.

Mathematics Computation Research Group, Department of Mathematics, Faculty of Mathematics and Natural Science, University of Indonesia, Depok, Indonesia.

Dengue fever is still a major threat worldwide, approximately threatening two-fifths of the world's population in tropical and subtropical countries. Nonstructural protein 5 (NS5) methyltransferase enzyme plays a vital role in the process of messenger RNA capping of dengue by transferring methyl groups from -adenosyl-l-methionine to N7 atom of the guanine bases of RNA and the RNA ribose group of 2'OH, resulting in -adenosyl-l-homocysteine (SAH). The modification of SAH compound was screened using molecular docking and molecular dynamics simulation, along with computational ADME-Tox (absorption, distribution, metabolism, excretion, and toxicity) test. Read More

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http://dx.doi.org/10.1177/1177392817701726DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5404899PMC
April 2017
33 Reads

Immunoinformatics Approach in Designing Epitope-based Vaccine Against Meningitis-inducing Bacteria (, , and Type b).

Drug Target Insights 2016 1;10:19-29. Epub 2016 Nov 1.

Bioinformatics Research Group, Department of Chemistry, Faculty of Mathematics and Science, University of Indonesia, Indonesia.

Meningitis infection is one of the major threats during Hajj season in Mecca. Meningitis vaccines are available, but their uses are limited in some countries due to religious reasons. Furthermore, they only give protection to certain serogroups, not to all types of meningitis-inducing bacteria. Read More

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http://dx.doi.org/10.4137/DTI.S38458DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5091093PMC
November 2016
28 Reads

Effects and Safety of Linagliptin as an Add-on Therapy in Advanced-Stage Diabetic Nephropathy Patients Taking Renin-Angiotensin-Aldosterone System Blockers.

Drug Target Insights 2016 11;10:13-8. Epub 2016 Sep 11.

Division of Nephrology.

Background: We investigated the effects and safety of linagliptin as an add-on therapy in patients with advanced-stage diabetic nephropathy (DMN) taking renin-angiotensin-aldosterone system (RAAS) blockers.

Method: Twenty advanced-stage DMN patients (estimated glomerular filtration rate (eGFR): 24.5 ± 13. Read More

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http://dx.doi.org/10.4137/DTI.S38339DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5019128PMC
September 2016
10 Reads

Gentamicin-Impregnated Collagen Sponge: Effectiveness in Preventing Sternal Wound Infection in High-Risk Cardiac Surgery.

Drug Target Insights 2016 29;10(Suppl 1):9-13. Epub 2016 May 29.

Department of Cardiac Surgery, Citta' di Lecce Hospital, Lecce, Italy.

Sternal wound infections represent one of the most frequent complications after cardiac surgery and are associated with high postoperative mortality. Several preventive methods have been introduced, and recently, gentamicin-impregnated collagen sponges (GICSs) have shown a promising effect in reducing the incidence of this type of complications. Gentamicin is an aminoglycoside antibiotic that has been widely used to treat infections caused by multiresistant bacteria; despite its effectiveness, its systemic use carries a risk of toxicity. Read More

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http://dx.doi.org/10.4137/DTI.S39077DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4886695PMC
June 2016
6 Reads

A Case of Organizing Pneumonia (OP) Associated with Pembrolizumab.

Drug Target Insights 2016 22;10:9-12. Epub 2016 May 22.

Fourth Department of Internal Medicine, Hematology-Oncology Unit, Attikon University Hospital, National and Kapodistrian University of Athens, Athens, Greece.

Until recently, chemotherapy for metastatic melanoma had disappointing results. The identification of immune checkpoints such as CTLA-4 and PD-1/PD-L1 has led to the development of an array of monoclonal antibodies (Mabs). These immunologic approaches against tumoral cells come with a novel kind of side effects that the clinician needs to be familiarized with. Read More

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http://journals.sagepub.com/doi/10.4137/DTI.S31565
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http://dx.doi.org/10.4137/DTI.S31565DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4877140PMC
June 2016
5 Reads

Brain Histamine N-Methyltransferase As a Possible Target of Treatment for Methamphetamine Overdose.

Drug Target Insights 2016 2;10:1-7. Epub 2016 Mar 2.

Department of Pharmacology, Hyogo College of Medicine, Hyogo, Japan.

Stereotypical behaviors induced by methamphetamine (METH) overdose are one of the overt symptoms of METH abuse, which can be easily assessed in animal models. Currently, there is no successful treatment for METH overdose. There is increasing evidence that elevated levels of brain histamine can attenuate METH-induced behavioral abnormalities, which might therefore constitute a novel therapeutic treatment for METH abuse and METH overdose. Read More

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http://journals.sagepub.com/doi/10.4137/DTI.S38342
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http://dx.doi.org/10.4137/DTI.S38342DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4777238PMC
March 2016
8 Reads

Preliminary In Vivo Evaluation of a Hybrid Armored Vascular Graft Combining Electrospinning and Additive Manufacturing Techniques.

Drug Target Insights 2016 28;10(Suppl 1):1-7. Epub 2016 Feb 28.

Tissue Engineering Laboratory, Università Campus Bio-Medico di Roma, Rome, Italy.

In this study, we tested in vivo effectiveness of a previously developed poly-l-lactide/poly-ε-caprolactone armored vascular graft releasing heparin. This bioprosthesis was designed in order to overcome the main drawbacks of tissue-engineered vascular grafts, mainly concerning poor mechanical properties, thrombogenicity, and endothelialization. The bioprosthesis was successfully implanted in an aortic vascular reconstruction model in rabbits. Read More

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http://dx.doi.org/10.4137/DTI.S35202DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4772909PMC
March 2016
14 Reads

Screening Analogs of β-OG Pocket Binder as Fusion Inhibitor of Dengue Virus 2.

Drug Target Insights 2015 16;9:33-49. Epub 2015 Nov 16.

Mathematics Computation Research Group, Faculty of Mathematics and Science, Department of Mathematics, University of Indonesia, Jawa Barat, Indonesia.

Dengue is an infectious disease caused by dengue virus (DENV) and transmitted between human hosts by mosquitoes. Recently, Indonesia was listed as a country with the highest cases of dengue by the Association of Southeast Asian Nations. The current treatment for dengue disease is supportive therapy; there is no antiviral drug available in the market against dengue. Read More

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http://dx.doi.org/10.4137/DTI.S31566DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4651419PMC
November 2015
13 Reads
2 Citations

Management of Diabetes Associated with Nephrotic Syndrome: Therapeutic Potential of Dapagliflozin for Protracted Volume Retention.

Drug Target Insights 2015 11;9:29-31. Epub 2015 Nov 11.

Division of Nephrology, Department of Internal Medicine, Jichi Medical University, Shimotsuke-shi, Tochigi, Japan.

A 48-year-old female was admitted to our hospital presenting with a chief complaint of progressive swelling because of diabetic nephrotic syndrome. Dapagliflozin seemed to play a role in accelerating the patient's urinary sodium excretion as well as reducing gross fluid retention despite the fact that her nephrotic condition was resistant to furosemide. Our experience emphasizes a potential novel approach to overcoming loop diuretic resistance using this agent among some subsets of type 2 diabetic subjects complicated with severe volume accumulation. Read More

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http://dx.doi.org/10.4137/DTI.S31710DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4644139PMC
November 2015
23 Reads

Basal Plasma Levels of Copeptin are Elevated in Inactive Inflammatory Bowel Disease after Bowel Resection.

Drug Target Insights 2015 13;9:21-7. Epub 2015 Jul 13.

Department of Clinical Sciences, Section of Internal Medicine, Skåne University Hospital, Malmö, and Lund University, Lund, Sweden.

Evidence of interactions between the enteric nervous system, neuropeptides, and the immune system is growing. The aim of this study was to examine basal plasma levels of a variety of peptide precursors in patients with inflammatory bowel disease (IBD). In two middle-aged cohorts, Malmö Preventive Medicine (n = 5,415) and Malmö Diet and Cost Study (n = 6,103), individuals with the diagnosis of IBD were identified. Read More

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http://dx.doi.org/10.4137/DTI.S26589DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4501700PMC
August 2015
14 Reads

Medicinal Plants: A Potential Source of Compounds for Targeting Cell Division.

Drug Target Insights 2015 15;9:9-19. Epub 2015 Jun 15.

PAP Rashidah Sa'adatul Bolkiah Institute of Health Sciences, Universiti Brunei Darussalam, Gadong, Brunei Darussalam.

Modern medicinal plant drug discovery has provided pharmacologically active compounds targeted against a multitude of conditions and diseases, such as infection, inflammation, and cancer. To date, natural products from medicinal plants remain a solid niche as a source from which cancer therapies can be derived. Among other properties, one favorable characteristic of an anticancer drug is its ability to block the uncontrollable process of cell division, as cancer cells are notorious for their abnormal cell division. Read More

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http://journals.sagepub.com/doi/10.4137/DTI.S24946
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http://dx.doi.org/10.4137/DTI.S24946DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4468949PMC
June 2015
21 Reads

7-NI and ODQ Disturbs Memory in the Elevated Plus Maze, Morris Water Maze, and Radial Arm Maze Tests in Mice.

Drug Target Insights 2015 4;9:1-8. Epub 2015 Mar 4.

Department of Pharmacology, Kocaeli University Medical Faculty, Kocaeli, Turkey.

Nitric oxide (NO) is an atypical neurotransmitter that causes changes in cognition. Nitric oxide synthase (NOS) and guanylate cyclase (GC) inhibitors have been shown to exert some effects on cognition in previous studies; however, the findings have been controversial. This study was aimed at understanding the effects of an NOS inhibitor, 7-nitroindazole (7-NI), and a guanylate cyclase inhibitor, 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one (ODQ), on spatial memory in modified elevated plus maze (mEPM), Morris water maze (MWM), and radial arm maze (RAM) tests. Read More

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http://dx.doi.org/10.4137/DTI.S23378DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4354329PMC
March 2015
7 Reads

Genome-wide Analysis of Mycoplasma hominis for the Identification of Putative Therapeutic Targets.

Drug Target Insights 2014 9;8:51-62. Epub 2014 Dec 9.

Department of Genetic Engineering & Biotechnology, University of Dhaka, Dhaka, Bangladesh.

Ever increasing propensity of antibiotic resistance among pathogenic bacteria raises the demand for the development of novel therapeutic agents to control this grave problem. Advances in the field of bioinformatics, genomics, and proteomics have greatly facilitated the discovery of alternative drugs by swift identification of new drug targets. In the present study, we employed comparative genomics and metabolic pathway analysis with an aim of identifying therapeutic targets in Mycoplasma hominis. Read More

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http://dx.doi.org/10.4137/DTI.S19728DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4263438PMC
January 2015
5 Reads

The Expression of Serum Antibodies Against Gonadotropin-releasing Hormone (GnRH1), Progonadoliberin-2, Luteinizing Hormone (LH), and Related Receptors in Patients with Gastrointestinal Dysfunction or Diabetes Mellitus.

Drug Target Insights 2014 10;8:45-50. Epub 2014 Nov 10.

Department of Clinical Sciences, Section of Internal Medicine, Skåne University Hospital, Malmö, Sweden. Lund University, Lund, Sweden.

Gonadotropin-releasing hormone (GnRH) 1 and 2 and luteinizing hormone (LH) receptors have been described in the gastrointestinal tract. We have previously demonstrated antibodies in serum against GnRH1 in patients with gastrointestinal dysfunction and diabetes mellitus, and antibodies against GnRH receptor, LH, and LH receptor in patients with infertility. The aim of this study was to search for the expression of serum antibodies against GnRH1 with an improved enzyme-linked immune sorbent assay (ELISA), and antibodies against progonadoliberin-2, GnRH2, GnRH receptor, LH, and LH receptor with newly developed ELISAs, in patients with gastrointestinal dysfunction or diabetes mellitus. Read More

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http://dx.doi.org/10.4137/DTI.S19352DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4227618PMC
December 2014
7 Reads

Febuxostat for hyperuricemia in patients with advanced chronic kidney disease.

Drug Target Insights 2014 13;8:39-43. Epub 2014 Aug 13.

Division of Nephrology, Department of Internal Medicine, Jichi Medical University, Tochigi, Japan.

Febuxostat is a nonpurine xanthine oxidase (XO) inhibitor, which recently received marketing approval. However, information regarding the experience with this agent among advanced chronic kidney disease (CKD) patients is limited. In the current study, we investigated the effects of oral febuxostat in patients with advanced CKD with asymptomatic hyperuricemia. Read More

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http://dx.doi.org/10.4137/DTI.S16524DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4134003PMC
September 2014
12 Reads

Molecular and Kinetic Characterization of Babesia microti Gray Strain Lactate Dehydrogenase as a Potential Drug Target.

Drug Target Insights 2014 28;8:31-8. Epub 2014 Jul 28.

National Research Center for Protozoan Diseases (NRCPD), Obihiro University of Agriculture and Veterinary Medicine, Inada-cho, Obihiro, Hokkaido, Japan.

Babesia microti is an emerging zoonotic protozoan organism that causes "malaria-like" symptoms that can be fatal in immunocompromised people. Owing to lack of specific therapeutic regiment against the disease, we cloned and characterized B. microti lactate dehydrogenase (BmLDH) as a potential molecular drug receptor. Read More

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http://dx.doi.org/10.4137/DTI.S16504DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4125376PMC
August 2014
12 Reads

Effects of zaprinast and rolipram on olfactory and visual memory in the social transmission of food preference and novel object recognition tests in mice.

Drug Target Insights 2014 29;8:23-9. Epub 2014 Apr 29.

Medical Faculty, Department of Pharmacology, Kocaeli University, Kocaeli, Turkey.

The role of phosphodiesterase (PDE) inhibitors in central nervous system has been investigated and shown to stimulate neuronal functions and increase neurogenesis in Alzheimer patients. The aim of this study is to investigate effect of PDE5 inhibitor zaprinast and PDE4 inhibitor rolipram on visual memory in novel object recognition (NOR) test, on olfactory memory in social transmission of food preference (STFP) test, and also on locomotion and anxiety in open field test in naive mice. Male Balb-c mice were treated intraperitoneally (i. Read More

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http://dx.doi.org/10.4137/DTI.S14813DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4011720PMC
May 2014
8 Reads

The Antidepressant Agomelatine Improves Memory Deterioration and Upregulates CREB and BDNF Gene Expression Levels in Unpredictable Chronic Mild Stress (UCMS)-Exposed Mice.

Drug Target Insights 2014 5;8:11-21. Epub 2014 Mar 5.

Pharmacology, Kocaeli University Medical Faculty, Kocaeli, Turkey.

Agomelatine, a novel antidepressant with established clinical efficacy, acts as an agonist of melatonergic MT1 and MT2 receptors and as an antagonist of 5-HT2C receptors. The present study was undertaken to investigate whether chronic treatment with agomelatine would block unpredictable chronic mild stress (UCMS)-induced cognitive deterioration in mice in passive avoidance (PA), modified elevated plus maze (mEPM), novel object recognition (NOR), and Morris water maze (MWM) tests. Moreover, the effects of stress and agomelatine on brain-derived neurotrophic factor (BDNF) and cyclic adenosine monophosphate (cAMP) response element binding protein (CREB) messenger ribonucleic acid (mRNA) levels in the hippocampus was also determined using quantitative real-time polymerase chain reaction (RT-PCR). Read More

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http://dx.doi.org/10.4137/DTI.S13870DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3948735PMC
March 2014
13 Reads

In Silico Molecular Characterization of Cysteine Protease YopT from Yersinia pestis by Homology Modeling and Binding Site Identification.

Drug Target Insights 2014 13;8:1-9. Epub 2014 Jan 13.

Department of Genetic Engineering and Biotechnology, Faculty of Biological Sciences, University of Chittagong, Chittagong-4331, Bangladesh.

Plague is a major health concern and Yersinia pestis plays the central causal role in this disease. Yersinia pestis has developed resistance against the commonly available drugs. So, it is now a key concern to find a new drug target. Read More

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http://dx.doi.org/10.4137/DTI.S13529DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3921076PMC
February 2014
6 Reads

Microscopic colitis and reproductive factors related to exposure to estrogens and progesterone.

Drug Target Insights 2013 7;7:53-62. Epub 2013 Oct 7.

Department of Clinical Sciences, Division of Internal Medicine, Skåne University Hospital, Malmö, Lund University, Lund, Sweden.

Microscopic colitis (MC) often debuts around or after menopause and is divided into lymphocytic- and collagenous colitis. The aim of this study was to examine whether factors influencing sex hormone levels differed between subgroups of MC as well as between patients and controls. A self-administered questionnaire about parity was completed which included questions surrounding age at first childbirth, menarche and menopause, the use of oral contraceptives, and hormonal replacement therapy. Read More

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http://dx.doi.org/10.4137/DTI.S12889DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3795533PMC
October 2013
4 Reads

Hsp60 chaperonin acts as barrier to pharmacologically induced oxidative stress mediated apoptosis in tumor cells with differential stress response.

Drug Target Insights 2013 1;7:35-51. Epub 2013 Sep 1.

CSIR-Centre for Cellular and Molecular Biology, Uppal Road, Hyderabad 500007, Andhra Pradesh, India.

Mitochondrial functions play a central role in energy metabolism and provide survival fitness to both normal and tumor cells. Mitochondrial chaperonin Hsp60 is involved in both pro- and anti-apoptotic functions, but how Hsp60 senses the mitochondria selective oxidative stress response is unknown. In this study, by using rotenone, an irreversible inhibitor of oxidative phosphorylation against IMR-32 and BC-8 tumor cells containing differential heat shock transcriptional machinery, we studied whether the oxidative stress response is related to Hsp60. Read More

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http://dx.doi.org/10.4137/DTI.S12513DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3767580PMC
September 2013
16 Reads

P-glycoprotein Inhibition for Optimal Drug Delivery.

Authors:
Md Lutful Amin

Drug Target Insights 2013 Aug 19;7:27-34. Epub 2013 Aug 19.

Department of Pharmacy, Stamford University Bangladesh, Dhaka, Bangladesh.

P-glycoprotein (P-gp), an efflux membrane transporter, is widely distributed throughout the body and is responsible for limiting cellular uptake and the distribution of xenobiotics and toxic substances. Hundreds of structurally diverse therapeutic agents are substrates to it and it impedes the absorption, permeability, and retention of the drugs, extruding them out of the cells. It is overexpressed in cancer cells and accountable for obstructing cell internalization of chemotherapeutic agents and for developing transporter mediated resistance by cancer cells during anti-tumor treatments. Read More

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http://dx.doi.org/10.4137/DTI.S12519DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3762612PMC
August 2013
8 Reads
37 Citations

Microscopic Colitis is Associated with Several Concomitant Diseases.

Drug Target Insights 2013 11;7:19-25. Epub 2013 Aug 11.

Department of Clinical Sciences, Section of Internal Medicine, Skåne University Hospital, Lund University, Sweden.

Microscopic colitis (MC) is a disease with intestinal mucosal inflammation causing diarrhea, affecting predominantly middle-aged women. The etiology is unknown, but increased prevalence of autoimmune diseases in these patients has been described, although not compared with controls or adjusted for confounding factors. The aim of this study was to examine the prevalence of common diseases in patients with MC and controls from the general population. Read More

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http://journals.sagepub.com/doi/10.4137/DTI.S12109
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http://dx.doi.org/10.4137/DTI.S12109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3748089PMC
September 2013
4 Reads

Impact of hepatocyte growth factor on skeletal myoblast transplantation late after myocardial infarction.

Drug Target Insights 2013 6;7:9-17. Epub 2013 May 6.

IWK Health Centre, Halifax, Nova Scotia, Canada. ; Dalhousie University Department of Surgery, Halifax, Nova Scotia, Canada. ; Dalhousie University Department of Physiology and Biophysics, Halifax, Nova Scotia, Canada.

In clinical studies, skeletal myoblast (SKMB) transplantation late after myocardial infarction (MI) has minimal impact on left ventricular (LV) function. This may be related to our previous observation that the extent of SKMB engraftment is minimal in chronic MI when compared to acute MI, which correlates with decreased hepatocyte growth factor (HGF) expression, an important regulator of SKMB function. Here, we investigated delivery of exogenous HGF as a strategy for augmenting SKMB engraftment late after MI. Read More

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http://journals.sagepub.com/doi/10.4137/DTI.S11802
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http://dx.doi.org/10.4137/DTI.S11802DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3653889PMC
May 2013
13 Reads

Antibodies against gonadotropin-releasing hormone in patients with posterior laryngitis.

Drug Target Insights 2013 28;7:1-8. Epub 2013 Jan 28.

Department of Clinical Sciences, Division of Otorhinolaryngology, Skåne University Hospital, Malmö, Lund University, Lund, Sweden.

Patients with functional gastrointestinal disorders express antibodies against gonadotropin-releasing hormone (GnRH) in serum. One common cause of posterior laryngitis (PL) is extra-esophageal reflux, but a functional etiology has also been suggested. The aim of this study was to scrutinize patients with PL with regard to the presence of GnRH antibodies and to examine the association between antibodies and symptoms and reflux. Read More

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http://dx.doi.org/10.4137/DTI.S10837DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3562083PMC
February 2013
6 Reads

Drug Target Exploitable Structural Features of Adenylyl Cyclase Activity in Schistosoma mansoni.

Drug Target Insights 2012 24;6:41-58. Epub 2012 Oct 24.

Center for Bioinformatics & Computational Biology, Department of Biology, Jackson State University, Jackson, MS, USA. ; Department of Environmental Sciences, College of Agriculture and Environmental Sciences, University of South Africa, South Africa.

The draft genome sequence of the parasitic flatworm Schistosoma mansoni (S. mansoni), a cause of schistosomiasis, encodes a predicted guanosine triphosphate (GTP) binding protein tagged Smp_059340.1. Read More

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http://dx.doi.org/10.4137/DTI.S10219DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3487612PMC
November 2012
4 Reads

17AAG Treatment Accelerates Doxorubicin Induced Cellular Senescence: Hsp90 Interferes with Enforced Senescence of Tumor Cells.

Drug Target Insights 2012 6;6:19-39. Epub 2012 Aug 6.

CSIR Centre for Cellular and Molecular Biology, Uppal Road, Hyderabad 500 007, Andhra Pradesh, India.

Hsp90 chaperone has been identified as an attractive pharmacological target to combat cancer. However, some metastatic tumors either fail to respond to Hsp90 inhibition or show recovery necessitating irreversible therapeutic strategies. In response to this enforced senescence has been proposed as an alternate strategy. Read More

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http://dx.doi.org/10.4137/DTI.S9943DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3422084PMC
August 2012
13 Reads

Expression of Luteinizing Hormone Receptor in the Gastrointestinal Tract in Patients with and without Dysmotility.

Drug Target Insights 2012 23;6:13-8. Epub 2012 Apr 23.

Department of Clinical Sciences, Section of Gastroenterology and Hepatology, Skåne University Hospital, Entrance 35, 205 02 Malmö, Lund University, Sweden.

Leuprolide is a gonadotropin-releasing hormone (GnRH) analog which has been shown to reduce symptoms in patients with irritable bowel syndrome (IBS) and chronic intestinal pseudo-obstruction (CIPO). The mechanism is not known, but one hypothesis is through down-modulation of luteinizing hormone (LH) secretion, a hormone whith antagonistic effect on gastrointestinal motility. However, presence of LH receptors in the gastrointestinal tract has never been described. Read More

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http://dx.doi.org/10.4137/DTI.S9324DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3342076PMC
August 2012
10 Reads

Resveratrol Targeting of Carcinogen-Induced Brain Endothelial Cell Inflammation Biomarkers MMP-9 and COX-2 is Sirt1-Independent.

Drug Target Insights 2012 11;6:1-11. Epub 2012 Apr 11.

Laboratoire d'Oncologie Moléculaire, Centre de Recherche BioMED, Université du Québec à Montréal, Quebec, Canada.

The occurrence of a functional relationship between the release of metalloproteinases (MMPs) and the expression of cyclooxygenase (COX)-2, two inducible pro-inflammatory biomarkers with important pro-angiogenic effects, has recently been inferred. While brain endothelial cells play an essential role as structural and functional components of the blood-brain barrier (BBB), increased BBB breakdown is thought to be linked to neuroinflammation. Chemopreventive mechanisms targeting both MMPs and COX-2 however remain poorly investigated. Read More

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http://dx.doi.org/10.4137/DTI.S9442DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3329184PMC
August 2012
11 Reads

Predictors of Virologic Failure in HIV/AIDS Patients Treated with Highly Active Antiretroviral Therapy in Brasília, Brazil During 2002-2008.

Drug Target Insights 2011 24;5:33-41. Epub 2011 Nov 24.

M.Sc. in Health Sciences, Nucleus of Virology, Central Public Health Laboratory, Brasilia, DF, Brazil, CEP 70830-010.

Little data exists concerning the efficacy of the antiretroviral therapy in the Federal District in Brazil, therefore in order to improve HIV/AIDS patients' therapy and to pinpoint hot spots in the treatment, this research work was conducted. Of 139 HIV/AIDS patients submitted to the highly active antiretroviral therapy, 12.2% failed virologically. Read More

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http://dx.doi.org/10.4137/DTI.S7527DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3236001PMC
August 2012
7 Reads

Repercussion of Mitochondria Deformity Induced by Anti-Hsp90 Drug 17AAG in Human Tumor Cells.

Drug Target Insights 2011 7;5:11-32. Epub 2011 Jun 7.

Centre for Cellular and Molecular Biology, Hyderabad 500 007, Uppal Road, India.

Inhibiting Hsp90 chaperone roles using 17AAG induces cytostasis or apoptosis in tumor cells through destabilization of several mutated cancer promoting proteins. Although mitochondria are central in deciding the fate of cells, 17AAG induced effects on tumor cell mitochondria were largely unknown. Here, we show that Hsp90 inhibition with 17AAG first affects mitochondrial integrity in different human tumor cells, neuroblastoma, cervical cancer and glial cells. Read More

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http://dx.doi.org/10.4137/DTI.S6582DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3178438PMC
November 2011
12 Reads

The effect of valproic Acid on mesenchymal pluripotent cell proliferation and differentiation in extracellular matrices.

Drug Target Insights 2011 22;5:1-9. Epub 2011 Mar 22.

Department of Morphological Biology, Fukuoka Dental College, 2-15-1 Tamura, Sawara-ku, Fukuoka 814-0193, Japan.

Valproic acid (2-n-propylpentanoic acid, VPA) is a widely used antiepileptic and anticonvulsant drug. Previous studies have reported that VPA effects osteogenesis in vivo and in vitro, yet it remains unclear whether VPA promotes cell differentiation of osteoblasts derived from mesenchymal cells. The purpose of this study was to clarify the effect of VPA on undifferentiated pluripotent mesenchymal cell proliferation and differentiation into osteoblasts while analyzing the impact of the absence or presence of extracellular matrices (ECMs). Read More

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http://journals.sagepub.com/doi/10.4137/DTI.S6534
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http://dx.doi.org/10.4137/DTI.S6534DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3086343PMC
November 2011
4 Reads

A Model for NAD(P)H:Quinoneoxidoreductase 1 (NQO1) Targeted Individualized Cancer Chemotherapy.

Drug Target Insights 2009 15;4:1-8. Epub 2009 Jan 15.

Manitoba Institute of Cell Biology, CancerCare Manitoba, Departments of Internal Medicine and Pharmacology and Therapeutics, University of Manitoba, 675 McDermot Avenue, Winnipeg, Manitoba R3E 0V9 Canada.

NQO1 (NAD(P)H:quinoneoxidoreductase 1) is a reductive enzyme that is an important activator of bioreductive antitumor agents. NQO1 activity varies in individual tumors but is generally higher in tumor cells than in normal cells. NQO1 has been used as a target for tumor specific drug development. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3086316PMC
November 2011
6 Reads

Effects of ascorbic Acid, alpha-tocopherol and allopurinol on ischemia-reperfusion injury in rabbit skeletal muscle: an experimental study.

Drug Target Insights 2007 21;2:249-58. Epub 2007 Nov 21.

Department of Cardiovascular Surgery, Atatürk University Medical Faculty, Erzurum, Turkey.

Purpose: Ischemia reperfusion injury to skeletal muscle, following an acute arterial occlusion is important cause of morbidity and mortality. The aim of the present study was to determine and evaluate the effects of ascorbic acide, alpha-tocopherol and allopurinol on ischemia reperfusion injury in rabbit skeletal muscle.

Methods: Forty-eight New Zealand white rabbits, all male, weighing between 2. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3155224PMC
October 2011
9 Reads

Platelet-derived growth factor as a therapeutic target for systemic autoimmune diseases.

Drug Target Insights 2007 30;2:239-47. Epub 2007 Oct 30.

Division of Rheumatology/Clinical Immunology, Department of Internal Medicine, Saitama Medical Center, Saitama Medical University, Kawagoe, Saitama, Japan.

Some systemic rheumatic diseases and disorders, especially fibrotic and vascular disorders, are often refractory to corticosteroid therapy. Recently, ever accumulating evidence suggests that platelet-derived growth factor (PDGF) is involved in those refractory diseases. Imatinib mesylate inhibits the activation of PDGF receptor as well as c-Abl, Bcr-Abl and c-Kit tyrosine kinases. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3155225PMC
October 2011
4 Reads

New insights into the understanding of gastrointestinal dysmotility.

Drug Target Insights 2007 25;2:229-37. Epub 2007 Sep 25.

Department of Clinical Sciences, Gastroenterology Division, Entrance 46, 2nd floor, University Hospital Malmö, Lund University, 20502 Malmö, Sweden.

Our understanding of the physiology of digestion, absorption, secretion, and motility in the gastrointestinal tract has improved immensely. Today it is well established that the gross functions of the gastrointestinal tract depend on the coordination between the muscles, nerves and hormones. The enteric nervous system (ENS) is involved in most of the physiological and pathophysiological processes in the gastrointestinal tract. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3155233PMC
October 2011
5 Reads

Effect of live Salmonella Ty21a in dextran sulfate sodium-induced colitis.

Drug Target Insights 2007 18;2:221-8. Epub 2007 Sep 18.

Department of Medicine, Section for Gastroenterology, Haukeland University Hospital, Bergen, Norway.

Background: Intestinal microbiota seems to play an essential role in the development of inflammatory bowel diseases (IBD). We hypothesised that an oral vaccine based on live Salmonella typhi would be well tolerated and could even attenuate dextran sulfate sodium (DSS) induced colitis in rats, an animal model of IBD.

Methods: Nine male Wistar rats was used for an initial tolerance study, in which we used 3 dose-levels of Salmonella Ty21a, 0. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3155226PMC
October 2011
34 Reads

Use and safety of anthroposophic medications for acute respiratory and ear infections: a prospective cohort study.

Drug Target Insights 2007 14;2:209-19. Epub 2007 Sep 14.

Institute for Applied Epistemology and Medical Methodology, Freiburg, Germany.

Objective: Anthroposophic medications (AMED) are widely used, but safety data on AMED from large prospective studies are sparse. The objective of this analysis was to determine the frequency of adverse drug reactions (ADR) to AMED in outpatients using AMED for acute respiratory and ear infections.

Methods: A prospective four-week observational cohort study was conducted in 21 primary care practices in Europe and the U. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3155242PMC
October 2011
6 Reads

Targeted brain tumor treatment-current perspectives.

Drug Target Insights 2007 17;2:197-207. Epub 2007 Aug 17.

Department of Pediatric Neurooncology and Molecular Pharmacology, Hoskins Center, Curtis and Elizabeth Anderson Cancer Institute, Memorial Health University Medical Center, Mercer University Medical School, 4700 Waters Avenue, Savannah, GA 31404, U.S.A.

Brain tumor is associated with poor prognosis. The treatment option is severely limited for a patient with brain tumor, despite great advances in understanding the etiology and molecular biology of brain tumors that have lead to breakthroughs in developing pharmaceutical strategies, and ongoing NCI/Pharma-sponsored clinical trials. We reviewed the literature on molecular targeted agents in preclinical and clinical studies in brain tumor for the past decade, and observed that the molecular targeting in brain tumors is complex. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3155235PMC
October 2011
3 Reads

Delivery systems for in vivo use of nucleic Acid drugs.

Drug Target Insights 2007 9;2:183-96. Epub 2007 Aug 9.

Departamento de Bioquímica, Instituto de Química, Universidade de São Paulo, São Paulo 05508-900, SP, Brazil.

The notorious biotechnological advance of the last few decades has allowed the development of experimental methods for understanding molecular mechanisms of genes and new therapeutic approaches. Gene therapy is maturing into a viable, practical method with the potential to cure a variety of human illnesses. Some nucleic-acid-based drugs are now available for controlling the progression of genetic diseases by inhibiting gene expression or the activity of their gene products. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3155220PMC
October 2011
4 Reads

Targeting human immunodeficiency virus type 1 assembly, maturation and budding.

Drug Target Insights 2007 20;2:159-82. Epub 2007 Jul 20.

Molecular Interactions Group, Macfarlane Burnet Institute for Medical Research and Public Health, Melbourne, Victoria, 3004, Australia.

The targets for licensed drugs used for the treatment of human immunodeficiency virus type 1 (HIV-1) are confined to the viral reverse transcriptase (RT), protease (PR), and the gp41 transmembrane protein (TM). While currently approved drugs are effective in controlling HIV-1 infections, new drug targets and agents are needed due to the eventual emergence of drug resistant strains and drug toxicity. Our increased understanding of the virus life-cycle and how the virus interacts with the host cell has unveiled novel mechanisms for blocking HIV-1 replication. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3155237PMC
October 2011
9 Reads

Polymeric nanoparticles, nanospheres and nanocapsules, for cutaneous applications.

Drug Target Insights 2007 11;2:147-57. Epub 2007 Jul 11.

Programa de Pós-Graduação em Ciências Farmacêuticas, Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul, UFRGS, Porto Alegre, RS, Brazil.

This review presents an overview about pharmaceutical and cosmetic topical products containing polymeric nanoparticles (nanospheres and nanocapsules), reporting the main preparation and characterization methods and the studies of penetration and transport of substances through the skin. The penetration and transport extent of those systems through the skin depends on the ingredients chemical composition, on the encapsulation mechanism influencing the drug release, on the size of nanoparticles and on the viscosity of the formulations. The polymeric nanoparticles are able to modify the activity of drugs, delay and control the drug release, and increase the drug adhesivity or its time of permanence in the skin. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3155227PMC
October 2011
13 Reads

Trypanothione reductase: a viable chemotherapeutic target for antitrypanosomal and antileishmanial drug design.

Authors:
M Omar F Khan

Drug Target Insights 2007 19;2:129-46. Epub 2007 Jun 19.

College of Pharmacy, Southwestern Oklahoma State University, 100 Campus Drive, Weatherford, OK 73096, U.S.A.

Trypanosomiasis and leishmaniasis are two debilitating disease groups caused by parasites of Trypanosoma and Leishmania spp. and affecting millions of people worldwide. A brief outline of the potential targets for rational drug design against these diseases are presented, with an emphasis placed on the enzyme trypanothione reductase. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3155241PMC
October 2011
4 Reads

The relationship of arginine deprivation, argininosuccinate synthetase and cell death in melanoma.

Drug Target Insights 2007 15;2:119-28. Epub 2007 Jun 15.

VA Medical Center, Hematology-Oncology, Miami, Florida, U.S.A.

It has been shown that melanoma cells do not express argininosuccinate synthetase (ASS) and therefore are unable to synthesize arginine from citrulline. Depleting arginine using pegylated arginine deiminase (ADI-PEG20) results in cell death in melanoma but not normal cells. This concept was translated into clinical trial and responses were seen. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3155228PMC
October 2011
7 Reads

Endothelial dysfunction, erectile dysfunction and phosphodiesterase 5 inhibitors. An update of the current data and future perspectives.

Drug Target Insights 2007 29;2:111-7. Epub 2007 May 29.

Department of Urology, University Hospital of Patras, Greece.

Endothelial dysfunction is a pathological entity that multiply affects the health status. Erectile dysfunction is being recognized as a condition that is strongly interrelated with endothelial dysfunction, being a vascular event itself. Oral pharmacotherapy for erectile dysfunction has provided us with a new armamentarium on this condition. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3155232PMC
October 2011
5 Reads