1,269 results match your criteria Drug Metabolism Reviews[Journal]


The pathogenic microbial flora and its antibiotic susceptibility pattern in odontogenic infections.

Drug Metab Rev 2019 Apr 18:1-46. Epub 2019 Apr 18.

a Universitatea din Oradea Facultatea de Medicina si Farmacie, Dental Medicine , Oradea , 410073 Romania.

Suppurative head and neck infections of odontogenic origin are the most frequent type of head and neck infections. According to the literature, 7-10% of all antibiotics are currently prescribed for their treatment. Since penicillin was invented, the overall antibiotic sensitivity and resistance pattern of the isolated pathogenic microflora has continuously changed. Read More

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http://dx.doi.org/10.1080/03602532.2019.1602630DOI Listing

Mycotoxin patulin in food matrices: occurrence and its biological degradation strategies.

Drug Metab Rev 2019 Mar 11:1-48. Epub 2019 Mar 11.

a College of Food Science and Engineering , Northwest A&F University , Yangling , 712100 , China.

Patulin is a mycotoxin produced by a number of filamentous fungal species. It is a polyketide secondary metabolite which can gravely cause human health problems and food safety issues. This review deals with the occurrence of patulin in major food commodities from 2008 to date, including historical aspects, source, toxicity, and its regulatory limits. Read More

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http://dx.doi.org/10.1080/03602532.2019.1589493DOI Listing
March 2019
1 Read
5.356 Impact Factor

Graphene Nano-ribbon Based high potential and Efficiency for DNA, Cancer therapy and drug delivery applications.

Drug Metab Rev 2019 Feb 20:1-35. Epub 2019 Feb 20.

a Department of Medical Nanotechnology, School of Advanced Medical Sciences and Technologies , Shiraz University of Medical Sciences , Shiraz , Iran.

At this article, graphene oxide Nano ribbons (GONRs) and its high potential for using in medical fields have been reviewed. Recently, Graphene Nano ribbons (GNRs) has been a field of interest in biological methods and disease treatment such as drug delivery, DNA applications, and photothermal cancer therapies. GNRs demonstrate more efficient properties rather than other graphene-based Nanomaterials due to their larger surface area. Read More

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http://dx.doi.org/10.1080/03602532.2019.1582661DOI Listing
February 2019

Applications of graphene oxide in case of nanomedicines and nanocarriers for biomolecules: review study.

Drug Metab Rev 2019 Feb 11:1-30. Epub 2019 Feb 11.

d Department of Chemical Engineering, South Tehran Branch , Islamic Azad University , Tehran , Iran.

In this Review article, recent progress in matter of graphene oxide (GO) synthesis and its functionalization via a vast range of materials, including small molecules, polymers, and biomolecules, were reported and systematically summarized in order to overcome the inherent drawbacks of GO nanocarriers and thereby make these nanocarriers suitable for delivering chemotherapeutic agents, genes, and short interfering RNAs. Briefly, this work describes current strategies for the large scale production of GO and modification of graphene-based nanocarriers surfaces through practical chemical approaches, improving their biocompatibility and declining their toxicity. It also describes the most relevant cases of study suitable to demonstrate the role of graphene and graphene derivatives (GD) as nanocarrier for anti-cancer drugs and genes (e. Read More

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http://dx.doi.org/10.1080/03602532.2018.1522328DOI Listing
February 2019
1 Read

Human cytochrome P450 enzymes 5-51 as targets of drugs and natural and environmental compounds: mechanisms, induction, and inhibition - toxic effects and benefits.

Drug Metab Rev 2018 08;50(3):256-342

b Department of Biochemistry , Vanderbilt University School of Medicine , Nashville , TN , USA.

Cytochrome P450 (P450, CYP) enzymes have long been of interest due to their roles in the metabolism of drugs, pesticides, pro-carcinogens, and other xenobiotic chemicals. They have also been of interest due to their very critical roles in the biosynthesis and metabolism of steroids, vitamins, and certain eicosanoids. This review covers the 22 (of the total of 57) human P450s in Families 5-51 and their substrate selectivity. Read More

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http://dx.doi.org/10.1080/03602532.2018.1483401DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421578PMC
August 2018
1 Read

Singularities of nevirapine metabolism: from sex-dependent differences to idiosyncratic toxicity.

Drug Metab Rev 2019 Feb 3:1-15. Epub 2019 Feb 3.

a CEDOC, Chronic Diseases Research Centre, NOVA Medical School/Faculdade de Ciências Médicas , Universidade NOVA de Lisboa , Lisboa , Portugal.

Nevirapine (NVP) is a first-generation non-nucleoside reverse transcriptase inhibitor widely used for the treatment and prophylaxis of human immunodeficiency virus infection. The drug is taken throughout the patient's life and, due to the availability of an extended-release formulation, it is administered once daily. This antiretroviral is one of the scarce examples of drugs with prescription criteria based on sex, in order to prevent adverse reactions. Read More

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http://dx.doi.org/10.1080/03602532.2019.1577891DOI Listing
February 2019
5 Reads

Cannabinoids and Bone Regeneration.

Drug Metab Rev 2019 Jan 31:1-20. Epub 2019 Jan 31.

c Department of Maxillofacial Surgery and Implantology , University of Medicine and Pharmacy "Iuliu Hatieganu" , Cluj-Napoca , Romania.

Bone is a complex tissue of the with unique properties such as high strength and regeneration capabilities while carrying out multiple functions. Bone regeneration occurs both in physiological situations (bone turnover) and pathological situations (e.g. Read More

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https://www.tandfonline.com/doi/full/10.1080/03602532.2019.1
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http://dx.doi.org/10.1080/03602532.2019.1574303DOI Listing
January 2019
10 Reads

Novel insights into the pharmacometabonomics of first-line tuberculosis drugs relating to metabolism, mechanism of action and drug-resistance.

Drug Metab Rev 2018 11 7;50(4):466-481. Epub 2019 Jan 7.

a Human Metabolomics , North-West University , Potchefstroom , South Africa.

The World Health Organization recommends the directly observed therapy short-course (DOTS) regimen, a combination of four first-line antibiotics (isoniazid, rifampicin, pyrazinamide and ethambutol), for the treatment of active pulmonary tuberculosis (TB). However, despite the fact that this treatment regimen is commonly used worldwide, the metabolism and anti-bacterial mechanisms of these drugs are not yet fully understood. This lack of information ultimately contributes to the poor patient compliance and the subsequent treatment failure and post treatment relapse seen in some TB patients. Read More

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http://dx.doi.org/10.1080/03602532.2018.1559184DOI Listing
November 2018
1 Read

Regulation of brain drug metabolizing enzymes and transporters by nuclear receptors.

Drug Metab Rev 2018 11 7;50(4):407-414. Epub 2019 Jan 7.

b Center for Pharmacogenetics and Department of Pharmaceutical Sciences , University of Pittsburgh , Pittsburgh , PA , USA.

Nuclear receptors (NRs) belong to a family of ligand-dependent transcription factors. The target genes of NRs include many drug metabolizing enzymes and transporters. The central nervous system (CNS) bears the expression of NRs, drug metabolizing enzymes and transporters. Read More

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https://www.tandfonline.com/doi/full/10.1080/03602532.2018.1
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http://dx.doi.org/10.1080/03602532.2018.1554673DOI Listing
November 2018
20 Reads

The engagement of brain cytochrome P450 in the metabolism of endogenous neuroactive substrates: a possible role in mental disorders.

Drug Metab Rev 2018 11 7;50(4):415-429. Epub 2019 Jan 7.

a Department of Pharmacokinetics and Drug Metabolism, Institute of Pharmacology , Polish Academy of Sciences , Kraków , Poland.

The current state of knowledge indicates that the cerebral cytochrome P450 (CYP) plays an important role in the endogenous metabolism in the brain. Different CYP isoenzymes mediate metabolism of many endogenous substrates such as monoaminergic neurotransmitters, neurosteroids, cholesterol, vitamins and arachidonic acid. Therefore, these enzymes may affect brain development, susceptibility to mental and neurodegenerative diseases and may contribute to their pathophysiology. Read More

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http://dx.doi.org/10.1080/03602532.2018.1554674DOI Listing
November 2018
2 Reads

Aldehyde toxicity and metabolism: The role of aldehyde dehydrogenases in detoxification, drug resistance and carcinogenesis.

Drug Metab Rev 2018 Dec 4:1-61. Epub 2018 Dec 4.

a Enzymology Laboratory , Interdisciplinary Biotechnology Unit, Aligarh Muslim University , Aligarh , 202002 , India.

Aldehydes are carbonyl compounds found ubiquitously in the environment, derived from both natural and anthropogenic sources. As the aldehydes are reactive species, therefore, they are generally toxic to the body. To reduce the toxicity and pathogenesis related to aldehydes, the human body contains several aldehyde metabolizing enzyme systems including aldehyde oxidases, cytochrome P450 enzymes, aldo-ketoreductases, alcohol dehydrogenases, short-chain dehydrogenases/reductases and aldehyde dehydrogenases (ALDHs). Read More

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http://dx.doi.org/10.1080/03602532.2018.1555587DOI Listing
December 2018
2 Reads
5.356 Impact Factor

Clinical pharmacokinetics of drugs in cardiopulmonary associated cachexia without hepatorenal pathology: a systematic review.

Drug Metab Rev 2018 Nov 18:1-11. Epub 2018 Nov 18.

b Department of Pharmacy , COMSATS Institute of Information Technology (CIIT) , Khyber Pakhtun Khwa , Abbottabad , Pakistan.

Cachexia not only has a dramatically harmful impact on a patient's life, but also a poor response to therapeutic agents. The purpose of the present review is to provide updated information concerning the pharmacokinetic aspects of drugs used to treat cardiopulmonary cachexia in patients with no signs of hepatic or renal pathology. A systematic search of PubMed, the Cochrane Central Register of Control Trials, Science Direct, and Clinical Trials Registry (ClinicalTrials. Read More

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https://www.tandfonline.com/doi/full/10.1080/03602532.2018.1
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http://dx.doi.org/10.1080/03602532.2018.1508226DOI Listing
November 2018
18 Reads

Mechanistic investigation of resistance via drug-inactivating enzymes in Mycobacterium tuberculosis.

Drug Metab Rev 2018 11 18;50(4):448-465. Epub 2018 Nov 18.

a Molecular Modeling Lab (MML), Department of Pharmaceutical Sciences and Drug Research , Punjabi University , Patiala , India.

Tuberculosis (TB) is a serious major health concern that has existed from millennia. According to annual WHO report 2016, it is considered as world's ninth highest killer disease by single infectious agent, ranking above HIV/AIDS. To worsen the scenario the development of multi-drug resistant tuberculosis (MDR-TB) and extremely drug-resistant tuberculosis (XDR-TB) have significantly reduced the success rate of TB treatment. Read More

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http://dx.doi.org/10.1080/03602532.2018.1533966DOI Listing
November 2018
2 Reads

Subcellular drug distribution: mechanisms and roles in drug efficacy, toxicity, resistance, and targeted delivery.

Drug Metab Rev 2018 11 29;50(4):430-447. Epub 2018 Sep 29.

a Department of Pharmacology , Shanghai University of Traditional Chinese Medicine , Shanghai , China.

After administration, drug molecules usually enter target cells to access their intracellular targets. In eukaryotic cells, these targets are often located in organelles, including the nucleus, endoplasmic reticulum, mitochondria, lysosomes, Golgi apparatus, and peroxisomes. Each organelle type possesses unique biological features. Read More

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http://dx.doi.org/10.1080/03602532.2018.1512614DOI Listing
November 2018
15 Reads

Gut microbiota modulates drug pharmacokinetics.

Drug Metab Rev 2018 08 19;50(3):357-368. Epub 2018 Sep 19.

a School of Pharmacy, Lanzhou University , Lanzhou , China.

Gut microbiota, one of the determinants of pharmacokinetics, has long been underestimated. It is now generally accepted that the gut microbiota plays an important role in drug metabolism during enterohepatic circulation either before drug absorption or through various microbial enzymatic reactions in the gut. In addition, some drugs are metabolized by the intestinal microbiota to specific metabolites that cannot be formed in the liver. Read More

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https://www.tandfonline.com/doi/full/10.1080/03602532.2018.1
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http://dx.doi.org/10.1080/03602532.2018.1497647DOI Listing
August 2018
41 Reads

Alterations of drug-metabolizing enzymes and transporters under diabetic conditions: what is the potential clinical significance?

Drug Metab Rev 2018 08 16;50(3):369-397. Epub 2018 Sep 16.

a Department of Pharmacy , Children's Hospital of Nanjing Medical University , Nanjing , China.

There will be 642 million people worldwide by 2040 suffering from diabetes mellitus. Long-term multidrug therapy aims to achieve normal glycemia and minimize complications, and avoid severe hypoglycemic events. The appreciation of the drug-metabolizing enzymes and drug transporters as critical players in the treatment of diabetes has attracted much attention regarding their potential alterations in the pathogenesis of the disease. Read More

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http://dx.doi.org/10.1080/03602532.2018.1497645DOI Listing
August 2018
5 Reads

Insights into the intestinal bacterial metabolism of flavonoids and the bioactivities of their microbe-derived ring cleavage metabolites.

Drug Metab Rev 2018 08 16;50(3):343-356. Epub 2018 Jul 16.

a School of Traditional Chinese Medicine , Tianjin University of Traditional Chinese Medicine , Tianjin , China.

Flavonoids are a group of phytochemicals widely distributed in plants, fruits, and vegetables that possess numerous bioactivities. After oral administration, flavonoids can be metabolized by the intestinal bacteria into a wide range of low-molecular-weight phenolic acids. In this review, the intestinal bacterial metabolic pathways of different flavonoids (flavones, isoflavones, flavonols, flavanones, and chalcones) and the bioactivities of their microbe-derived ring cleavage metabolites are summarized. Read More

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http://dx.doi.org/10.1080/03602532.2018.1485691DOI Listing
August 2018
5 Reads
5.360 Impact Factor

The mesentery: an ADME perspective on a 'new' organ.

Drug Metab Rev 2018 08 16;50(3):398-405. Epub 2018 Jul 16.

b Department of Pharmacokinetic Sciences , Novartis Institutes for BioMedical Research, Inc , Cambridge , MA , USA.

With the inclusion of mesentery, the total number of human organs has recently increased by one. The mesentery was formerly construed to be a complex, discontinuous anatomical structure simply serving as a support for organs in abdominal cavity. However, recent research has established the mesentery to be a far more simple and unfragmented organ. Read More

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http://dx.doi.org/10.1080/03602532.2018.1484756DOI Listing
August 2018
7 Reads

Biotransformation and bioactivation reactions - 2017 literature highlights .

Drug Metab Rev 2018 08 28;50(3):221-255. Epub 2018 Jun 28.

d Division of Toxicology , Wageningen University , Wageningen , The Netherlands.

This annual review is the third one to highlight recent advances in the study and assessment of biotransformations and bioactivations ( Table 1 ). We followed the same format as the previous years with selection and authoring each section (see Baillie et al. 2016 ; Khojasteh et al. Read More

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http://dx.doi.org/10.1080/03602532.2018.1473875DOI Listing
August 2018
1 Read

The synthetic cathinone α-pyrrolidinovalerophenone (α-PVP): pharmacokinetic and pharmacodynamic clinical and forensic aspects.

Drug Metab Rev 2018 05 14;50(2):125-139. Epub 2018 Mar 14.

a Department of Public Health, Forensic Sciences, and Medical Education, Faculty of Medicine , University of Porto , Porto , Portugal.

New psychoactive substances (NPS), often referred as 'legal highs' or 'designer drugs', are derivatives and analogs of existing psychoactive drugs that are introduced in the recreational market to circumvent existing legislation on drugs of abuse. This work aims to review the state-of-the-art regarding chemical, molecular pharmacology, and in vitro and in vivo data on toxicokinetics of the potent synthetic cathinone α-pyrrolidinovalerophenone (α-PVP or flakka or zombie drug). Chemical, pharmacological, toxicological, and clinical effects of α-PVP were searched in PubMed (U. Read More

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https://www.tandfonline.com/doi/full/10.1080/03602532.2018.1
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http://dx.doi.org/10.1080/03602532.2018.1448867DOI Listing
May 2018
21 Reads

Effects of 5-Aza-2'-deoxycytidine (decitabine) on gene expression.

Drug Metab Rev 2018 05 18;50(2):193-207. Epub 2018 Feb 18.

a Department of Surgical and Hospital Dentistry, Division of Craniofacial Development and Anomalies , ULSD, University of Louisville , Louisville , KY , USA.

5-Aza-2'-deoxycytidine (AzaD), also known as Decitabine, is a deoxycytidine analog that is typically used to activate methylated and silenced genes by promoter demethylation. However, a survey of the scientific literature indicates that promoter demethylation may not be the only (or, indeed, the major) mechanism by which AzaD affects gene expression. Regulation of gene expression by AzaD can occur in several ways, including some that are independent of DNA demethylation. Read More

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http://dx.doi.org/10.1080/03602532.2018.1437446DOI Listing
May 2018
5 Reads

Cytochrome P450 in the central nervous system as a therapeutic target in neurodegenerative diseases.

Drug Metab Rev 2018 05 16;50(2):95-108. Epub 2018 Feb 16.

a Departamento de Medicina Genómica y Toxicología Ambiental, Instituto de Investigaciones Biomédicas , Universidad Nacional Autónoma de México , Ciudad de México, México.

Cytochromes P450 (CYPs) constitute a family of enzymes that can be found in the endoplasmic reticulum (ER), mitochondria or the cell surface of the cells. CYPs are characterized by carrying out the oxidation of organic compounds and they are mainly recognized as mediators of the biotransformation of xenobiotics to polar hydrophilic metabolites that can be eliminated from the organism. However, these enzymes play a key role in many other physiological processes, being involved in diverse indispensable metabolic pathways since they metabolize many endogenous substrates. Read More

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http://dx.doi.org/10.1080/03602532.2018.1439502DOI Listing
May 2018
7 Reads

Towards a better understanding of the cannabinoid-related orphan receptors GPR3, GPR6, and GPR12.

Drug Metab Rev 2018 02 1;50(1):74-93. Epub 2018 Feb 1.

a Department of Chemistry and Biochemistry , University of North Carolina at Greensboro , Greensboro , NC , USA.

GPR3, GPR6, and GPR12 are three orphan receptors that belong to the Class A family of G-protein-coupled receptors (GPCRs). These GPCRs share over 60% of sequence similarity among them. Because of their close phylogenetic relationship, GPR3, GPR6, and GPR12 share a high percentage of homology with other lipid receptors such as the lysophospholipid and the cannabinoid receptors. Read More

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http://dx.doi.org/10.1080/03602532.2018.1428616DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6093286PMC
February 2018
8 Reads

Targeting the endocannabinoid system as a potential anticancer approach.

Drug Metab Rev 2018 Feb 1;50(1):26-53. Epub 2018 Feb 1.

a Institute of Pharmacology and Toxicology , Rostock University Medical Center , Rostock , Germany.

The endocannabinoid system is currently under intense investigation due to the therapeutic potential of cannabinoid-based drugs as treatment options for a broad variety of diseases including cancer. Besides the canonical endocannabinoid system that includes the cannabinoid receptors CB and CB and the endocannabinoids N-arachidonoylethanolamine (anandamide) and 2-arachidonoylglycerol, recent investigations suggest that other fatty acid derivatives, receptors, enzymes, and lipid transporters likewise orchestrate this system as components of the endocannabinoid system when defined as an extended signaling network. As such, fatty acids acting at cannabinoid receptors (e. Read More

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http://dx.doi.org/10.1080/03602532.2018.1428344DOI Listing
February 2018
5 Reads

Difference and alteration in pharmacokinetic and metabolic characteristics of low-solubility natural medicines.

Drug Metab Rev 2018 05 1;50(2):140-160. Epub 2018 Feb 1.

a Chongqing Research Center for Pharmaceutical Engineering , Chongqing Medical University , Chongqing , PR China.

Drug metabolism plays vital roles in the absorption and pharmacological activity of poorly soluble natural medicines. It is important to choose suitable delivery systems to increase the bioavailability and bioactivity of natural medicines with low solubility by regulating their metabolism and pharmacokinetics. This review investigates recent developments about the metabolic and pharmacokinetic behavior of poorly soluble natural medicines and their delivery systems. Read More

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https://www.tandfonline.com/doi/full/10.1080/03602532.2018.1
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http://dx.doi.org/10.1080/03602532.2018.1430823DOI Listing
May 2018
12 Reads
5.360 Impact Factor

Pro-psychotic effects of synthetic cannabinoids: interactions with central dopamine, serotonin, and glutamate systems.

Drug Metab Rev 2018 Feb 31;50(1):65-73. Epub 2018 Jan 31.

a Department of Pharmacology and Toxicology , University of Arkansas for Medical Sciences, College of Medicine , Little Rock , AR , USA.

An association between marijuana use and schizophrenia has been noted for decades, and the recent emergence of high-efficacy synthetic cannabinoids (SCBs) as drugs of abuse has lead to a growing number of clinical reports of persistent psychotic effects in users of these substances. The mechanisms underlying SCB-elicited pro-psychotic effects is unknown, but given the ubiquitous neuromodulatory functions of the endocannabinoid system, it seems likely that agonist actions at cannabinoid type-1 receptors (CB1Rs) might modulate the functions of other neurotransmitter systems known to be involved in schizophrenia. The present review surveys what is currently known about the interactions of CB1Rs with dopamine, serotonin, and glutamate systems, because all three of those neurotransmitters are well-established in the pathophysiology of schizophrenia and psychosis. Read More

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http://dx.doi.org/10.1080/03602532.2018.1428343DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6419500PMC
February 2018
13 Reads

Preface to DMR special edition 'Cannabinoid receptors and ligands: therapeutic drug development and abuse potential'.

Authors:
Paul L Prather

Drug Metab Rev 2018 02 30;50(1):1-2. Epub 2018 Jan 30.

a Department of Pharmacology and Toxicology, College of Medicine , University of Arkansas for Medical Sciences , Little Rock , AR , USA.

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http://dx.doi.org/10.1080/03602532.2018.1431657DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6287905PMC
February 2018
7 Reads

Old and new synthetic cannabinoids: lessons from animal models.

Drug Metab Rev 2018 Feb 29;50(1):54-64. Epub 2018 Jan 29.

b Institute of Neuroscience-Cagliari, National Research Council of Italy, Cittadella Universitaria di Monserrato , Monserrato , Italy.

Synthetic cannabinoids have long been studied for their therapeutic potentials. However, during the last decade, new generations of synthetic cannabinoid agonists appeared on the drug market. These new psychoactive substances are currently sold as 'marijuana-like' products as they claim to mimic the effects of the psychoactive component of cannabis, delta-9-tetrahydrocannabinol (THC). Read More

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http://dx.doi.org/10.1080/03602532.2018.1430824DOI Listing
February 2018
4 Reads

The future of type 1 cannabinoid receptor allosteric ligands.

Drug Metab Rev 2018 02 21;50(1):14-25. Epub 2018 Jan 21.

a College of Pharmacy and Nutrition , University of Saskatchewan , Saskatoon , Canada.

Allosteric modulation of the type 1 cannabinoid receptor (CB1R) holds great therapeutic potential. This is because allosteric modulators do not possess intrinsic efficacy, but instead augment (positive allosteric modulation) or diminish (negative allosteric modulation) the receptor's response to endogenous ligand. Consequently, CB1R allosteric modulators have an effect ceiling which allows for the tempering of CB1R signaling without the desensitization, tolerance, dependence, and psychoactivity associated with orthosteric compounds. Read More

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http://dx.doi.org/10.1080/03602532.2018.1428341DOI Listing
February 2018
4 Reads

NAT1 genotypic and phenotypic contribution to urinary bladder cancer risk: a systematic review and meta-analysis.

Drug Metab Rev 2018 May 19;50(2):208-219. Epub 2017 Dec 19.

c Faculty of Medicine , Clinical Research Institute, American University of Beirut , Beirut , Lebanon.

N-acetyltransferase 1 (NAT1), a polymorphic Phase II enzyme, plays an essential role in metabolizing heterocyclic and aromatic amines, which are implicated in urinary bladder cancer (BCa). This systematic review investigates a possible association between the different NAT1 genetic polymorphisms and BCa risk. Medline, PubMed, EMBASE, Scopus, Web of Science, OpenGrey, and BASE databases were searched to identify eligible studies. Read More

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http://dx.doi.org/10.1080/03602532.2017.1415928DOI Listing
May 2018
7 Reads

A comprehensive review of recent studies on pharmacokinetics of traditional Chinese medicines (2014-2017) and perspectives.

Drug Metab Rev 2018 05 19;50(2):161-192. Epub 2017 Dec 19.

b Department of Pharmaceutical Analysis, School of Pharmacy , Fujian Medical University , Fuzhou , China.

Traditional Chinese medicines (TCMs) have a long history for safely treating human diseases. Unlike western medicine, TCMs usually contain multiple components synergistically and holistically acting on the diseases. It remains a big challenge to represent rationally the in vivo process of multiple components of TCMs for understanding the relationship between administration and therapeutic effects. Read More

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http://dx.doi.org/10.1080/03602532.2017.1417424DOI Listing
May 2018
20 Reads

Effect of cardiopulmonary bypass on cytochrome P450 enzyme activity: implications for pharmacotherapy.

Drug Metab Rev 2018 05 19;50(2):109-124. Epub 2017 Dec 19.

a Centre for Integrated Preclinical Drug Development, Centre for Clinical Research, Faculty of Medicine , The University of Queensland , Brisbane , QLD , Australia.

For patients undergoing cardiopulmonary bypass (CPB) during cardiac surgery, there are well-documented changes in the pharmacokinetics (PK) of commonly administered drugs. Although multiple factors potentially underpin these changes, there has been scant research attention on the impact of CPB to alter the activities of cytochrome P450 (CYP) isoenzymes. PK changes during cardiac surgery with CPB have the potential to adversely affect the safety and efficacy of pharmacotherapy and increase the risk of drug-drug interactions. Read More

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http://dx.doi.org/10.1080/03602532.2017.1417423DOI Listing
May 2018
7 Reads

Stereochemical considerations in pharmacokinetic processes of representative antineoplastic agents.

Drug Metab Rev 2017 11 27;49(4):438-450. Epub 2017 Oct 27.

a Department of Thoracic Surgery, Institute of Surgery Research , Daping Hospital, Third Military Medical University , Chongqing , China.

The vast majority of chemical drugs or drug candidates contain stereocenter(s) in their molecular structures. In these molecules, stereochemical properties are vital properties that influence or even determine their drug actions. Therefore, studying the stereochemical issues of drugs (or drug candidates) is necessary for rational drug use. Read More

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http://dx.doi.org/10.1080/03602532.2017.1394322DOI Listing
November 2017
9 Reads

Metabolic pathways and pharmacokinetics of natural medicines with low permeability.

Drug Metab Rev 2017 11 14;49(4):464-476. Epub 2017 Sep 14.

a Chongqing Research Center for Pharmaceutical Engineering , Chongqing Medical University , Chongqing , China.

Drug metabolism plays an important role in the drug disposal process. Differences in pharmacokinetics among individuals are the basis for personalized medicine. Natural medicines, formed by long-term evolution of nature, prioritize the action of a target protein with a drug. Read More

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http://dx.doi.org/10.1080/03602532.2017.1377222DOI Listing
November 2017
24 Reads

Metabolic profile of oxazepam and related benzodiazepines: clinical and forensic aspects.

Drug Metab Rev 2017 11 14;49(4):451-463. Epub 2017 Sep 14.

a IINFACTS - Institute of Research and Advanced Training in Health Sciences and Technologies, Department of Sciences , University Institute of Health Sciences (IUCS), CESPU, CRL , Gandra , Portugal.

Anxiolytic drugs, namely benzodiazepines, are the most commonly used psychoactive substances since anxiety disorders are prevalent mental disorders particularly in the Western world. Oxazepam is a short-acting benzodiazepine and one of the most frequently prescribed anxiolytic drugs. It is also the active metabolite of a wide range of other benzodiazepines, such as diazepam, ketazolam, temazepam, chlordiazepoxide, demoxazepam, halazepam, medazepam, prazepam, pinazepam, and chlorazepate. Read More

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http://dx.doi.org/10.1080/03602532.2017.1377223DOI Listing
November 2017
24 Reads

Paracetamol: overdose-induced oxidative stress toxicity, metabolism, and protective effects of various compounds in vivo and in vitro.

Drug Metab Rev 2017 11 16;49(4):395-437. Epub 2017 Aug 16.

a Department of Toxicology and Pharmacology, Faculty of Veterinary Medicine , Universidad Complutense de Madrid , Madrid , Spain.

Paracetamol (APAP) is one of the most widely used and popular over-the-counter analgesic and antipyretic drugs in the world when used at therapeutic doses. APAP overdose can cause severe liver injury, liver necrosis and kidney damage in human beings and animals. Many studies indicate that oxidative stress is involved in the various toxicities associated with APAP, and various antioxidants were evaluated to investigate their protective roles against APAP-induced liver and kidney toxicities. Read More

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http://dx.doi.org/10.1080/03602532.2017.1354014DOI Listing
November 2017
82 Reads

Human cytosolic glutathione-S-transferases: quantitative analysis of expression, comparative analysis of structures and inhibition strategies of isozymes involved in drug resistance.

Drug Metab Rev 2017 08 12;49(3):318-337. Epub 2017 Jul 12.

a Department of Biotechnology, Centre for Research , Kamaraj College of Engineering and Technology , Virudhunagar , India.

Glutathione-S-transferase (GST) inhibition is a strategy to overcome drug resistance. Several isoforms of human GSTs are present and they are expressed in almost all the organs. Specific expression levels of GSTs in various organs are collected from the human transcriptome data and analysis of the organ-specific expression of GST isoforms is carried out. Read More

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http://dx.doi.org/10.1080/03602532.2017.1343343DOI Listing
August 2017
16 Reads

Liver toxicity mechanisms of herbs commonly used in Latin America.

Drug Metab Rev 2017 08 4;49(3):338-356. Epub 2017 Jul 4.

a Translational Research Unit , Medica Sur Clinic & Foundation , Mexico City , Mexico.

Mexico owns approximately 4500 medicinal plants species, a great diversity that position it at the second place after China. According to the Mexican health department, 90% of common population consumes them to treat various diseases. Additionally, herbal remedies in Latin America (LA) are considered a common practice, but the frequency of use and the liver damage related to its consumption is still unknown. Read More

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http://dx.doi.org/10.1080/03602532.2017.1335750DOI Listing
August 2017
10 Reads
5.356 Impact Factor

Implications of sulfotransferase activity in interindividual variability in drug response: clinical perspective on current knowledge.

Drug Metab Rev 2017 08 20;49(3):357-371. Epub 2017 Jun 20.

a CEDOC, Chronic Diseases Research Centre, NOVA Medical School Faculdade de Ciências Médicas, Universidade NOVA de Lisboa , Lisboa , Portugal.

The interindividual variability in drug response is a major issue in clinical practice and in drug development. Sulfoconjugation is an important Phase II reaction catalyzed by cytosolic sulfotransferases (SULTs), playing a major role in homeostatic functions, xenobiotic detoxification, and carcinogen bioactivation. SULT display wide interindividual variability, explained only partially by genetic variation, suggesting that other non-genetic, epigenetic, and environmental influences could be major determinants of variability in SULT activity. Read More

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http://dx.doi.org/10.1080/03602532.2017.1335749DOI Listing
August 2017
7 Reads

Biotransformation and bioactivation reactions - 2016 literature highlights.

Drug Metab Rev 2017 08 31;49(3):285-317. Epub 2017 May 31.

d Department of Biochemistry and Molecular Biology , University of Arkansas for Medical Sciences , Little Rock , AR , USA.

We are pleased to present a second annual issue highlighting a previous year's literature on biotransformation and bioactivation. Each contributor to this issue worked independently to review the articles published in 2016 and proposed three to four articles, which he or she believed would be of interest to the broader research community. In each synopsis, the contributing author summarized the procedures, analyses and conclusions as described in the original manuscripts. Read More

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http://dx.doi.org/10.1080/03602532.2017.1326498DOI Listing
August 2017
7 Reads

Ocular non-P450 oxidative, reductive, hydrolytic, and conjugative drug metabolizing enzymes.

Drug Metab Rev 2017 08 17;49(3):372-394. Epub 2017 May 17.

c GreenBanana SEO , Beverly , MA , USA.

Metabolism in the eye for any species, laboratory animals or human, is gaining rapid interest as pharmaceutical scientists aim to treat a wide range of so-called incurable ocular diseases. Over a period of decades, reports of metabolic activity toward various drugs and biochemical markers have emerged in select ocular tissues of animals and humans. Ocular cytochrome P450 (P450) enzymes and transporters have been recently reviewed. Read More

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http://dx.doi.org/10.1080/03602532.2017.1322609DOI Listing
August 2017
5 Reads

The importance of drug metabolites synthesis: the case-study of cardiotoxic anticancer drugs.

Drug Metab Rev 2017 05 25;49(2):158-196. Epub 2017 Apr 25.

c Laboratório de Toxicologia, Departamento de Ciências Biológicas, Faculdade de Farmácia, UCIBIO, REQUIMTE (Rede de Química e Tecnologia) , Universidade do Porto , Porto , Portugal.

Anticancer drugs are presently guarantying more survivors as a result of more powerful drugs or combinations of drugs used in therapy. Thus, it has become more crucial to study and overcome the side effects of these therapies. Cardiotoxicity is one of the most relevant side effects on the long-term cancer survivors, because of its high social and economic impact. Read More

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http://dx.doi.org/10.1080/03602532.2017.1316285DOI Listing
May 2017
14 Reads

Non-alcoholic fatty liver disease (NAFLD) - pathogenesis, classification, and effect on drug metabolizing enzymes and transporters.

Drug Metab Rev 2017 05 17;49(2):197-211. Epub 2017 Mar 17.

a Clinical Pharmacokinetics Research Laboratory, Department of Biomedical and Pharmaceutical Sciences , University of Rhode Island , Kingston , RI , USA.

Non-alcoholic fatty liver disease (NAFLD) is a spectrum of liver disorders. It is defined by the presence of steatosis in more than 5% of hepatocytes with little or no alcohol consumption. Insulin resistance, the metabolic syndrome or type 2 diabetes and genetic variants of PNPLA3 or TM6SF2 seem to play a role in the pathogenesis of NAFLD. Read More

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http://dx.doi.org/10.1080/03602532.2017.1293683DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5576152PMC
May 2017
46 Reads

Raman spectroscopy using plasmonic and carbon-based nanoparticles for cancer detection, diagnosis, and treatment guidance. Part 2: Treatment.

Drug Metab Rev 2017 05 19;49(2):253-283. Epub 2017 Jun 19.

a Center for Integrative Nanotechnology Sciences, University of Arkansas at Little Rock , Little Rock , AR , USA.

Raman spectroscopy and surface-enhanced raman scattering (SERS) have the potential to improve the detection and monitoring of various diseases, particularly cancer, with or without the support of multifunctional active nanosystems. This review is focused on the recent advances that have made Raman a major tool for treatment guidance for surgical tumor resection or for analytical monitoring of various therapies, such as photodynamic therapy, photothermal therapy, and drug delivery. The potential of Raman spectroscopy and nanosytems to further improve cancer treatments is also discussed. Read More

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http://dx.doi.org/10.1080/03602532.2017.1307387DOI Listing
May 2017
53 Reads

The metabolism of berberine and its contribution to the pharmacological effects.

Drug Metab Rev 2017 05 3;49(2):139-157. Epub 2017 Apr 3.

a School of Chinese Materia Medica , Tianjin University of Traditional Chinese Medicine , Tianjin , P.R. China.

Berberine, a bioactive alkaloid isolated from several herbal substances, possesses multiple pharmacological effects, including antimicrobial, antidiabetic, anticancer activities. Meanwhile, berberine undergoes extensive metabolism after oral administration which results in its extremely low plasma exposure. Therefore, it is believed that the metabolites of berberine also contribute a lot to its pharmacological effects. Read More

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http://dx.doi.org/10.1080/03602532.2017.1306544DOI Listing
May 2017
10 Reads

Glucuronidation: driving factors and their impact on glucuronide disposition.

Drug Metab Rev 2017 05 22;49(2):105-138. Epub 2017 May 22.

c Department of Pharmacological and Pharmaceutical Sciences , College of Pharmacy, University of Houston , Houston , TX , USA.

Glucuronidation is a well-recognized phase II metabolic pathway for a variety of chemicals including drugs and endogenous substances. Although it is usually the secondary metabolic pathway for a compound preceded by phase I hydroxylation, glucuronidation alone could serve as the dominant metabolic pathway for many compounds, including some with high aqueous solubility. Glucuronidation involves the metabolism of parent compound by UDP-glucuronosyltransferases (UGTs) into hydrophilic and negatively charged glucuronides that cannot exit the cell without the aid of efflux transporters. Read More

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http://dx.doi.org/10.1080/03602532.2017.1293682DOI Listing
May 2017
9 Reads

Raman spectroscopy using plasmonic and carbon-based nanoparticles for cancer detection, diagnosis, and treatment guidance.Part 1: Diagnosis.

Drug Metab Rev 2017 05 15;49(2):212-252. Epub 2017 Jun 15.

a Center for Integrative Nanotechnology Sciences, University of Arkansas at Little Rock , Little Rock , AR , USA.

Optical techniques, including Raman, photothermal and photoacoustic microscopy and spectroscopy, have been intensively explored for the sensitive and accurate detection of various diseases. Rapid advances in lasers, photodetectors, and nanotechnology have led to the development of Raman spectroscopy, particularly surface-enhanced Raman scattering (SERS), as a promising imaging modality that can help diagnose many diseases. This review focuses on the major recent advances in Raman spectroscopy and SERS-enhancing contrast nanoagents, as well as their potential to transition from a proof-of-concept approach to a cancer detection tool in vitro and in vivo. Read More

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http://dx.doi.org/10.1080/03602532.2017.1302465DOI Listing
May 2017
19 Reads

Metabolism of psilocybin and psilocin: clinical and forensic toxicological relevance.

Drug Metab Rev 2017 02 31;49(1):84-91. Epub 2017 Jan 31.

a Department of Sciences, IINFACTS - Institute of Research and Advanced Training in Health Sciences and Technologies , University Institute of Health Sciences (IUCS), CESPU, CRL , Gandra , Portugal.

Psilocybin and psilocin are controlled substances in many countries. These are the two main hallucinogenic compounds of the "magic mushrooms" and both act as agonists or partial agonists at 5-hydroxytryptamine (5-HT) subtype receptors. During the last few years, psilocybin and psilocin have gained therapeutic relevance but considerable physiological variability between individuals that can influence dose-response and toxicological profile has been reported. Read More

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http://dx.doi.org/10.1080/03602532.2016.1278228DOI Listing
February 2017
14 Reads

Systemic drugs that influence titanium implant osseointegration.

Drug Metab Rev 2017 02 23;49(1):92-104. Epub 2017 Jan 23.

d Department of Maxillofacial Surgery and Oral Implantology , Iuliu Hatieganu University of Medicine and Pharmacy , Cluj-Napoca , Romania.

Titanium implants are widely used on an increasing number of patients in orthopedic and dental medicine. Despite the good survival rates of these implants, failures that lead to important socio-economic consequences still exist. Recently, research aimed at improving implant fixation, a process called osseointegration, has focused on a new, innovative field: systemic delivery of drugs. Read More

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http://dx.doi.org/10.1080/03602532.2016.1277737DOI Listing
February 2017
13 Reads