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Diving Hyperb Med 2022 Jun;52(2):149-153

Department of Underwater and Hyperbaric Medicine, Faculty of Medicine, Canakkale Onsekiz Mart University, Canakkale, Turkey.

Intramuscular injections are one of the most common clinical procedures. The objectives of this case series are to analyse the role, timing and efficacy of hyperbaric oxygen treatment (HBOT) in the management of Nicolau syndrome (NS), an extremely rare complication of this common intervention. Clinical, demographic, laboratory and microbiological data extraction were performed through retrospective analysis of the medical records of all patients with NS who were referred for HBOT over a 10-year period with wounds, ischaemia, infection or necrosis at the injection site following drug injection; four patients with NS were included. Read More

J Investig Allergol Clin Immunol 2022 06;32(3):243-244

Department of Internal Medicine, Qatar University College of Medicine, Doha, Qatar.

J Dtsch Dermatol Ges 2022 06;20(6):777-786

German Center for the Documentation of Severe Skin Reactions (dZh), Department of Dermatologie, Medical Center and Medical Faculty - University of Freiburg, Germany.

Background: Stevens-Johnson syndrome and toxic epidermal necrolysis are severe, primarily drug-induced reactions of skin and mucosa. Since they differ in the extent of skin detachment but not in etiology, they are grouped together as epidermal necrolysis (EN). Due to nationwide registration, representative data are available at the German Center for the Documentation of Severe Skin Reactions (dZh). Read More

PLoS Negl Trop Dis 2022 06 13;16(6):e0010476. Epub 2022 Jun 13.

Athena Institute, Faculty of Science, VU University Amsterdam, Amsterdam, Netherlands.

Background: Leprosy reactions, Type-1 and erythema nodosum leprosum, are immune-mediated complications of leprosy, which play a significant role in the morbidity associated with the disease. A considerable amount of literature has been published on the impact of leprosy in general but few studies focus specifically on leprosy reactions. This study aimed to investigate the impact of leprosy reactions on physical, psychological, and social aspects of the lives of people affected by analysing their life experiences and perspectives about leprosy reactions. Read More

Arerugi 2022 ;71(4):328-333

Department of Pediatrics, Kasugai Municipal Hospital.

We describe here the case of a 7-year-old male patient with Stevens-Johnson syndrome (SJS), which was suspected to be caused by treatment with tipepidine hibenzate (Asverin). The day after taking tipepidine hibenzate and L-carbocysteine (Carbocysteine DS) for relief of a cold, he began presenting with the following symptoms: fever above 38°C, wheezing, and decreased oxygen saturation. Two days later, mucous membrane rashes, such as erosions on the lips, eye mucosa, vulva, and blisters on the trunk appeared, and SJS was thus diagnosed. Read More

Prim Care Companion CNS Disord 2022 06 7;24(3). Epub 2022 Jun 7.

Department of Psychiatry, Central Institute of Psychiatry, Kanke, Ranchi, Jharkhand, India.

Integr Cancer Ther 2022 Jan-Dec;21:15347354221105485

Second Affiliated Hospital of Naval Medical University, Shanghai, China.

Background: Chemotherapy-induced adverse effects (CIAEs) remain a challenging problem due to their high incidences and negative impacts on treatment in Chinese colorectal cancer (CRC) patients. We aimed to identify risk factors and predictive markers for CIAEs using food/nutrition data in CRC patients receiving post-operative capecitabine-based chemotherapy.

Methods: Food/nutrition data from 130 Chinese CRC patients were analyzed. Read More

Paediatr Drugs 2022 Jul 9;24(4):307-319. Epub 2022 Jun 9.

Division of Dermatology, Department of Medicine, Sunnybrook Health Sciences Centre, Toronto, ON, Canada.

Pediatric Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare but life-threating blistering diseases triggered by medications that affect the skin and mucosae. Drug-induced epidermal necrolysis is a better term for medication-triggered cases because there is a spectrum of disease severity that otherwise is divided into the separate entities of SJS, overlap SJS/TEN, and TEN. This manuscript reviews the management of drug-induced epidermal necrolysis (DEN), including diagnosis, investigations to exclude differential diagnoses, and treatment. Read More

Cureus 2022 May 1;14(5):e24649. Epub 2022 May 1.

Anatomic Pathology, King Faisal Specialist Hospital and Research Centre, Jeddah, SAU.

Morbilliform eruption typically implies a maculopapular rash of acute onset. Drugs are the predominant cause of this cutaneous reaction in adults, followed by infectious exanthems and some rheumatological diseases. In this article, we report on the clinical and histopathological features of generalized pruritic morbilliform eruption in a 28-year-old female following her second dose of Oxford/AstraZeneca COVID-19 vaccine. Read More

Stem Cell Res 2022 Jul 25;62:102820. Epub 2022 May 25.

Laboratory of Cardiovascular Regenerative Medicine, Translational Vascular Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.

We have successfully generated induced pluripotent stem cells (iPSC) from dermal fibroblasts and peripheral blood mononuclear cells from patients with a homozygous missense mutation in the gene encoding PSMB8. Biallelic loss of function mutations in this gene are responsible for the PSMB8 deficiency termed Chronic atypical neutrophilic dermatosis with lipodystrophy and elevated temperature (CANDLE). The iPSC carrying the homozygous PSMB8 gene mutation (c. Read More

Cutis 2022 Apr;109(4):221-223

Dr. Kou is from Des Moines University College of Osteopathic Medicine, Iowa. Dr. Kolb is from Olmsted Medical Center, Rochester, Minnesota. Dr. Kelada is from Roseville Family Healthcare, California. Dr. Schmieder is from the Department of Dermatology, Orange Park Medical Center, Florida.

Blisters and subsequent desquamation of the skin in the presence of acute edema is a well-known clinical phenomenon. In this case report, we describe a new variant that we have termed anasarca-induced desquamation in a 50-year-old man with molting of the entire cutaneous surface after acute edema, in a setting of 40-lb weight gain over 5 days. Laboratory workup for infectious causes and punch biopsies of skin lesions ruled out Stevens-Johnson syndrome and staphylococcal scalded skin syndrome, which have a similar clinical presentation to anasarca-induced desquamation. Read More

Cutis 2022 02;109(2):E9-E12

Department of Dermatology and Cutaneous Surgery, University of South Florida College of Medicine, Tampa.

Cutis 2022 02;109(2):E29-E30

Division of Dermatology, University of Texas Health Science Center at San Antonio.

Cutis 2022 Mar;109(3):E29-E32

Department of Dermatology, Naval Medical Center, Camp Lejeune, North Carolina.

Angioimmunoblastic T-cell lymphoma (AITL) is a rare and aggressive lymphoma arising from follicular T-helper cells. Cutaneous findings and nonspecific systemic symptoms often associated with this malignancy can closely resemble those of more common entities, such as a viral exanthem or drug eruption, depending on the history and context. These similarities in presentation to more common entities can cause a delay in the diagnosis of AITL and subsequent initiation of treatment, which has considerable implications for morbidity and mortality. Read More

Cutis 2022 03;109(3):E12-E14

Dr. Patel is from the Long School of Medicine, University of Texas Health San Antonio. Drs. Cervantes, Keeling, and Adamson are from the Department of Internal Medicine, Division of Dermatology, Dell Medical School at Austin, Texas.

J Eur Acad Dermatol Venereol 2022 Jun 2. Epub 2022 Jun 2.

Dermatovenereology Department of Coimbra University Hospital, Coimbra, Portugal.

Eur J Dermatol 2022 Jan;32(1):154-156

Indian J Dent Res 2021 Oct-Dec;32(4):537-540

Department of Pediatric and Preventive Dentistry, Sri Ramachandra Institute of Higher Education and Research, Chennai, Tamil Nadu, India.

In the present era, the use of drugs is an important paradigm of health care. Reactions to drugs range from minor cutaneous reactions to potentially lethal conditions like Stevens-Johnson syndrome. A 13-year-old, male patient, known case of Stevens-Johnson Syndrome was referred from the pediatric ward for the management of oral mucosal lesions, post consumption of the antibiotic combination of sulfamethoxazole and trimethoprim. Read More

West Afr J Med 2022 May;39(5):538-542

Service de dermatologie-vénérologie, Centre National Hospitalier et Universitaire de Cotonou, Faculté des Sciences de la Santé - Université d'Abomey-Calavi.

Background: The aim of this study was to describe the epidemiological, clinical and etiological aspects of severe cutaneous adverse drug reactions in children in dermatologyvenereology unit at National and Teaching Hospital of Cotonou.

Methods: A retrospective and descriptive study was carried out for 10 years in dermatology-venereology unit at the National and Teaching Hospital of Cotonou to document the epidemiological, clinical and etiological aspects of severe cutaneous adverse drug reactions in children. It included all children aged from 0 to 18 years with clinical diagnosis of severe cutaneous adverse drug reactions. Read More

J Invest Dermatol 2022 May 18. Epub 2022 May 18.

Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, Baltimore, MD. Electronic address:

Cutaneous immune-related adverse events (cirAEs) are the most prevalent complication to arise from immunotherapy and cause significant morbidity. We aimed to determine the spectrum, timing, clinical features, and outcomes of cirAEs by conducting an observational pharmacovigilance study using VigiBase, the World Health Organization's global database of individual case safety reports from over 130 member countries (ClinicalTrials.gov, number NCT04898751). Read More

Clin Cosmet Investig Dermatol 2022 10;15:829-841. Epub 2022 May 10.

Department of Dermatology, Fukushima Medical University, Fukushima, Japan.

In accordance with recent therapeutic progress of immune checkpoint inhibitors for certain cancers, various disorders are induced as immune-related adverse events (irAEs) affecting the skin, gut, thyroid gland, lung, and liver. Among such irAEs, mucocutaneous manifestation is the most common. Cutaneous manifestations are categorized into several groups, ie, inflammatory reactions, immunobullous reactions, alterations of epidermal keratinocytes, and alterations of epidermal melanocytes; however, there are additionally various cutaneous toxicities, unclassified into those groups. Read More

Aust Prescr 2022 Apr 1;45(2):43-48. Epub 2022 Apr 1.

McGill University Health Centre, McGill University, Montreal, Quebec, Canada.

Severe cutaneous adverse drug reactions include Stevens-Johnson syndrome, toxic epidermal necrolysis and acute generalised exanthematous pustulosis. These eruptions are a type of delayed hypersensitivity reaction and can be life-threatening. The assessment of a severe cutaneous drug reaction requires a detailed clinical history and examination to identify the culprit drug and evaluate the allergy. Read More

Trials 2022 May 19;23(1):420. Epub 2022 May 19.

Department of Medical Oncology, Dr BR Ambedkar Institute Rotary Cancer Hospital, All India Institute of Medical Sciences, New Delhi, 110029, India.

Introduction: Hand-foot syndrome (HFS) is a common cutaneous side effect of capecitabine therapy. Apart from oral cyclooxygenase-2 (COX-2) inhibitor (celecoxib), there are no proven strategies for the prevention of HFS. However, celecoxib is associated with significant cardiotoxicity. Read More

J Cutan Med Surg 2022 May 18:12034754221100188. Epub 2022 May 18.

Faculty of Medicine, University of Toronto, Canada.

Acta Derm Venereol 2022 05 24;102:adv00723. Epub 2022 May 24.

Department of Dermatology, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto, Japan.

Lancet 2022 05;399(10338):1902

Department of Internal Medicine, Texas Tech University Health Sciences Center, Lubbock, TX, USA.

Biomater Sci 2022 Jun 14;10(12):3137-3157. Epub 2022 Jun 14.

School of Life Sciences, Anhui Agricultural University, Hefei 230036, China.

The treatment of sepsis caused by bacterial infections is still a huge clinical challenge. As sepsis causes high levels of endogenous HS , researchers can design nanomedicines to treat sepsis by sulfurization. Here, we designed and synthesized CuO-coated non-metallic core-shell selenium nanoparticles. Read More

Int J Dermatol 2022 May 11. Epub 2022 May 11.

Department of Internal Medicine, Division of Dermatology, The Ohio State University Wexner Medical Center.

Mod Rheumatol Case Rep 2022 May 11. Epub 2022 May 11.

Department of Rheumatology. Mayo Clinic Health System, Eau Claire, WI, USA.

Cutaneous lupus erythematosus (CLE) is one of the most common manifestation of systemic lupus erythematosus (SLE), although it can manifest as an independent entity as well. Bullous systemic lupus erythematosus (BSLE) is a rare cutaneous manifestation of SLE presenting as tense vesiculobullous eruptions in a photosensitive distribution. Pathophysiology is secondary to autoantibodies against noncollagenous domain 1 and 2 (NC1 and NC2) type VII collagen and histopathology reveals dense neutrophilic infiltration of the dermis with direct immunofluorescence showing IgG deposition at dermo-epidermal junction. Read More

J Eur Acad Dermatol Venereol 2022 06;36(6):764

Department of Dermatology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.