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    1 OF 474

    DRESS syndrome with thrombotic microangiopathy revealing a Noonan syndrome: Case report.
    Medicine (Baltimore) 2018 Apr;97(15):e0297
    Department of Internal Medicine, Rehabilitation and Geriatrics, Service of Internal Medicine, Geneva University Hospitals, rue Gabrielle Perret-Gentil, Geneva, Switzerland.
    Rationale: The life-threatening drug rash with eosinophilia and systemic symptoms (DRESS) syndrome occurs most commonly after exposure to drugs, clinical features mimic those found with other serious systemic disorders. It is rarely associated with thrombotic microangiopathy.

    Patient Concerns: We describe the unique case of a 44-year-old man who simultaneously experienced DRESS syndrome with thrombotic microangiopathy (TMA) after a 5 days treatment with fluindione. Read More

    Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) syndrome associated with cefotaxime and clindamycin use in a 6 year-old boy: a case report.
    Pan Afr Med J 2017 9;28:218. Epub 2017 Nov 9.
    Healthy Sciences University, Umraniye Training and Research Hospital, Department of Pediatrics, Istanbul, Turkey.
    Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a rare and potentially life-threatening idiosyncratic drug reaction. It presents with extensive rash, fever, lymphadenopathy, hematologic abnormalities (eosinophilia and/or atypical lymphocytosis) and internal organ involvement. It has been described in association with more than 50 drugs. Read More

    Prevalence of Hypersensitivity Reactions in Children Associated with Acetaminophen: A Systematic Review and Meta-Analysis.
    Int Arch Allergy Immunol 2018 Apr 3. Epub 2018 Apr 3.
    Background: Acetaminophen is the most commonly used antipyretic in children. However, there are limited data assessing hypersensitivity reactions related to acetaminophen usage.

    Objectives: To conduct a systematic review to characterize reported reactions to acetaminophen in adults and children, and perform a meta-analysis to assess the prevalence of acetaminophen hypersensitivity in children with a suspected acetaminophen allergy. Read More

    Severe Cutaneous Adverse Drug Reactions: Presentation, Risk Factors, and Management.
    Curr Allergy Asthma Rep 2018 Mar 24;18(4):26. Epub 2018 Mar 24.
    Department of Rheumatology, Immunology and Allergology, University Hospital and University of Bern, Bern, Switzerland.
    Purpose Of Study: Immune-mediated adverse drug reactions occur commonly in clinical practice and include mild, self-limited cutaneous eruptions, IgE-mediated hypersensitivity, and severe cutaneous adverse drug reactions (SCAR). SCARs represent an uncommon but potentially life-threatening form of delayed T cell-mediated reaction. The spectrum of illness ranges from acute generalized exanthematous pustulosis (AGEP) to drug reaction with eosinophilia with systemic symptoms (DRESS), to the most severe form of illness, Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). Read More

    [Severe skin reactions due to new medications].
    Hautarzt 2018 Apr;69(4):278-289
    Dokumentationszentrum schwerer Hautreaktionen (dZh), Universitätsklinik für Dermatologie und Venerologie, Hauptstr. 7, 79104, Freiburg, Deutschland.
    Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN) and a specific form of hypersensitivity syndrome which is nowadays called "drug reaction with eosinophilia and systemic symptoms" (DRESS) are severe, mainly drug-induced skin reactions. Whereas SJS/TEN is considered one reaction entity of different severity, DRESS has to be distinguished from SJS/TEN but also from other severe exanthems due to multiorgan involvement. Although SJS/TEN is generally referred to as drug reaction, in total only about three quarters of the cases are actually caused by drugs. Read More

    Drug eruptions in the mature patient.
    Clin Dermatol 2018 Mar - Apr;36(2):249-254. Epub 2017 Oct 3.
    Department of Dermatology and Venereology, University Hospital Center Zagreb, Zagreb, Croatia; School of Medicine University of Zagreb, Zagreb, Croatia.
    The world's population is now ageing at an unprecedented rate. Declining fertility and improved health and longevity have generated rising numbers and proportions of the older population in most parts of the world. With advancing age, however, comes an increasing incidence of disease (comorbidity or multimorbidity), an increasing use of medications (polypharmacy), and consequently an increase in adverse drug reactions (ADRs). Read More

    Drug-Induced Skin Adverse Reactions: The Role of Pharmacogenomics in Their Prevention.
    Mol Diagn Ther 2018 Mar 21. Epub 2018 Mar 21.
    Department of Pharmacology, Faculty of Medicine, University of Thessaly, Biopolis, 41500, Larissa, Greece.
    Adverse drug reactions (ADRs) affect many patients and remain a major public health problem, as they are a common cause of morbidity and mortality. It is estimated that ADRs are responsible for about 6% of hospital admissions and about 9% of hospitalization costs. Skin is the organ that is most frequently involved in ADRs. Read More

    Successful treatment of refractory demodicosis and transient papules with a single dose of fluralaner in a dog with uncontrolled severe endocrine disease.
    J Vet Med Sci 2018 Mar 8. Epub 2018 Mar 8.
    Department of Veterinary Nursing, School of Veterinary Nursing and Technology, Faculty of Veterinary Science, Nippon Veterinary and Life Science University.
    A 12-year-old female Shih-Tzu with hyperadrenocorticism and hypothyroidism developed concurrent refractory generalized demodicosis that did not respond to doramectin treatment. Although amitraz treatment was effective, the dog developed severe diabetes, which resulted in the cessation of amitraz and trilostane. Attempts to control the diabetes were unsuccessful, and its hyperadrenocorticism was left untreated, leading to the recurrence of demodicosis. Read More

    Nursing care of a boy seriously infected with Steven-Johnson syndrome after treatment with azithromycin: A case report and literature review.
    Medicine (Baltimore) 2018 Jan;97(1):e9112
    Department of Children's Critical Care Medicine, Xin-Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
    Rationale: Stevens-Johnson syndrome (SJS) is an acute blistering disease of the skin and mucous membranes. SJS in children is not common but potentially serious disease. But the epidemiology of SJS in China is not well defined. Read More

    A Feasibility Study of Capecitabine and Oxaliplatin for Patients with Stage II/III Colon Cancer -ACTOR Study.
    Anticancer Res 2018 03;38(3):1741-1747
    Department of Gastroenterological Surgery, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan.
    Background/aim: Past studies have suggested that adjuvant capecitabine and oxaliplatin (CAPOX) provides decreased tumor relapse and longer survival in patients with curatively resected colon cancer. We report the first evidence of the feasibility of adjuvant CAPOX in Japanese patients with early colon cancer.

    Patients And Methods: Eligible patients had histologically-confirmed stage II/III colon cancer and received curative resection. Read More

    Seborrheic Pemphigus, Antigen Mimicry and the Subsequent-Wrong Diagnostic and Therapeutic Approach?
    Open Access Maced J Med Sci 2018 Jan 13;6(1):128-131. Epub 2018 Jan 13.
    Medical Institute of Ministry of Interior (MVR-Sofia), Department of Dermatology, Venereology and Dermatologic Surgery, Sofia, Bulgaria.
    It is well-established that drugs could be leading cause of occurrence of numerous diseases, including pemphigus, being either inducer or triggering factor of the autoimmunity. Despite medications, it should be kept in mind that chronic or acute infections are also capable of being a trigger in various types of cutaneous eruptions, including pemphigus. The rapidly obtained and uncompleted history for accompanied medication leads to general mistakes in the subsequent treatment approach, as the first step in such cases is discontinuation of the drug-inductor. Read More

    Cytokine expression and cytokine-based T-cell profiling in occupational medicamentosa-like dermatitis due to trichloroethylene.
    Toxicol Lett 2018 May 22;288:129-135. Epub 2018 Feb 22.
    Shenzhen Center for Disease Control and Prevention, Shenzhen 518055, China. Electronic address:
    Early diagnosis and treatment of occupational medicamentosa-like dermatitis due to trichloroethylene (OMLDT) are absence of specific and reliable diagnostic/therapeutic biomarkers. This study was conducted on 30 cases of OMLDT, 58 workers exposed to trichloroethylene (TCE) and 40 unexposed controls in order to identify any cytokine signatures that give an index to CD4T cell differential and serve as biomarkers of OMLDT. Expression profiles of Th, Th, Th and Treg cell type-specifying transcription factors and cytokines were analyzed using real time quantitative PCR (RT-qPCR) assay. Read More

    Ponatinib-induced ichthyosiform drug eruption: insights into acquired ichthyosis.
    Dermatol Online J 2017 Oct 15;23(10). Epub 2017 Oct 15.
    Dermatology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.
    Cutaneous adverse events are commonly experienced with use of tyrosine kinase inhibitors in the treatment of leukemia and typically include nonspecific cutaneous eruptions and xerosis. We report the case of a man who experienced an ichthyosiform drug eruption while taking ponatinib, a third-generation tyrosine kinase inhibitor. Disruption of epidermal growth pathways through inhibition of various receptor tyrosine kinases by ponatinib may offer insights into the pathophysiologic mechanisms behind acquired ichthyosis. Read More

    Generalized bullous fixed drug eruption imitating toxic epidermal necrolysis: a case report and literature review.
    Dermatol Online J 2017 Jul 15;23(7). Epub 2017 Jul 15.
    Baylor College of Medicine, Department of Dermatology, Houston, Texas.
    Fixed drug eruption (FDE) is defined as sharply demarcated erythematous patches or plaques that occur secondary to systemic exposure to a causative medication. Eruptions are deemed "fixed" because upon repeated exposure they recur at previously affected sites. Generalized bullous fixed drug eruption (GBFDE) is a rare FDE variant occurring in patients with a previous history of FDE. Read More

    A patient case highlighting the myriad of cutaneous adverse effects of prolonged use of hydroxyurea.
    Dermatol Online J 2017 Nov 15;23(11). Epub 2017 Nov 15.
    Division of Dermatology, University of Kansas Medical Center, Kansas City, Kansas.
    Background: Hydroxyurea is an antimetabolite primarily used to treat myeloproliferative disorders, and chronic treatment is associated with many cutaneous adverse effects ranging in severity from ichthyosis to aggressive nonmelanoma skin cancer.

    Case Presentation: We report a 67-year-oldman with a history of polycythemia vera who was referred for management of progressively worsening dorsal hand lesions. The patient presented withhyperpigmentation, ichthyosis, plantar keratoderma, dermatomyositis-like eruptions, two squamous cell carcinomas, and actinic keratoses. Read More

    Pityriasis lichenoides-like drug reaction: A clinical histopathologic study of 10 cases.
    Dermatol Online J 2017 Nov 15;23(11). Epub 2017 Nov 15.
    Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, New York.
    Background: Lymphomatoid drug reactions can mimic endogenous T and B cell lymphoproliferative diseases.

    Objectives: We present a novel form of cutaneous drug reaction with features of pityriasis lichenoides (PL), a recognized form of T cell dyscrasia.

    Methods: Ten cases were studied where a cutaneous eruption exhibiting semblance to PL within a few weeks to months after starting a particular drug. Read More

    Treatments for Severe Cutaneous Adverse Reactions.
    J Immunol Res 2017 27;2017:1503709. Epub 2017 Dec 27.
    Department of Dermatology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.
    Severe cutaneous adverse reaction (SCAR) is life-threatening. It consists of Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN), drug reaction with eosinophilia and systemic symptoms (DRESS), acute generalized exanthematous pustulosis (AGEP), and generalized bullous fixed drug eruptions (GBFDE). In the past years, emerging studies have provided better understandings regarding the pathogenesis of these diseases. Read More

    ISMP Adverse Drug Reactions: Influenza Vaccine-Induced Stevens-Johnson Syndrome; Vilazodone-Induced Nightmares; Dabigatran-Induced Pustular Eruptions; Neurotoxic and Cardiotoxic Symptoms After Cannabis Concentrate Exposure; Rosuvastatin-Induced Skin Eruption.
    Hosp Pharm 2018 Feb 6;53(1):15-17. Epub 2017 Nov 6.
    Department of Pharmacy Practice, School of Pharmacy, Temple University, Philadelphia, PA, USA.
    The purpose of this feature is to heighten awareness of specific adverse drug reactions (ADRs), discuss methods of prevention, and promote reporting of ADRs to the US Food and Drug Administration's (FDA) MedWatch program (800-FDA-1088). If you have reported an interesting, preventable ADR to MedWatch, please consider sharing the account with our readers. Write to Dr. Read More

    A retrospective study of DRESS - drug reaction with eosinophilia and systemic symptoms.
    Psychiatr Pol 2017 Dec 30;51(6):1079-1093. Epub 2017 Dec 30.
    Klinika Dermatologii, Wenerologii i Alergologii Gdańskiego Uniwersytetu Medycznego.
    Objectives: DRESS (drug reaction with eosinophilia and systemic syndrome) is qualified as hypersensitivity after drug reaction. This syndrome may occur due to any medication intake. There are three main groups of symptoms defining DRESS: skin lesions, hematological abnormalities and internal organ involvement. Read More

    Cutaneous irritancy of an ibuprofen medicated plaster in healthy volunteers.
    Postgrad Med 2018 Apr 12;130(3):334-340. Epub 2018 Feb 12.
    d Medical Affairs and Clinical Research , R&D at Reckitt Benckiser , Slough , UK.
    Objectives: To assess the irritation and contact sensitization potential of a 200 mg ibuprofen medicated plaster.

    Methods: This double-blind, phase-1 placebo controlled study had two phases; the induction phase to evaluate the irritant potential of continuous application of the plaster, and the challenge phase to assess contact sensitivity (allergy). The cumulative irritancy potential was evaluated using an adaptation of the Shelanski method. Read More

    Occupational allergic contact dermatitis caused by antibiotics in healthcare workers - relationship with non-immediate drug eruptions.
    Contact Dermatitis 2018 Apr 5;78(4):281-286. Epub 2018 Feb 5.
    Dermatology Department, Coimbra Hospital and University Centre (CHUC), Praceta Prof. Mota Pinto, 3000-075, Coimbra, Portugal.
    Background: Occupational allergic contact dermatitis (ACD) in healthcare workers (HCWs) is common, but systemic antibiotics are rarely reported as the cause.

    Objectives: Characterize occupational ACD by handling systemic antibiotics.

    Method: A retrospective analysis was performed of ACD caused by systemic antibiotics among HCWs patch tested between 2010 and 2016 with a series of systemic antibiotics. Read More

    Different Toxicity of Cetuximab and Panitumumab in Metastatic Colorectal Cancer Treatment: A Systematic Review and Meta-Analysis.
    Oncology 2018 23;94(4):191-199. Epub 2018 Jan 23.
    Oncology Unit, Oncology Department, ASST Ospedale di Cremona, Cremona, Italy.
    Background: Over the last few years only one large randomized phase III study has tried to prospectively assess the safety of cetuximab and panitumumab in a head-to-head comparison. Despite the similar overall toxicity profile, cetuximab and panitumumab retain peculiar safety characteristics that deserve to be deeply investigated.

    Methods: We conducted a systematic review for randomized trials in PubMed, the Cochrane Central Register of Controlled Trials, SCOPUS, Web of Science, and EMBASE using the terms ("cetuximab" or "panitumumab") AND ("colorectal cancer" OR "colorectal carcinoma"). Read More

    Diverse cutaneous adverse eruptions caused by anti-programmed cell death-1 (PD-1) and anti-programmed cell death ligand-1 (PD-L1) immunotherapies: clinical features and management.
    Ther Adv Med Oncol 2018 22;10:1758834017751634. Epub 2018 Jan 22.
    Division of Dermatology 52-121 CHS, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.
    Background: The anti-programmed cell death-1 (PD-1) and anti-programmed cell death ligand-1 (PD-L1) immunotherapies have shown exceptional activity in many cancers. However, these immunotherapies can also result in diverse adverse cutaneous eruptions that need to be better characterized for ongoing management. The objective was to provide clinical and histopathologic descriptions of the variety of cutaneous adverse events seen in patients who received anti-PD-1/PD-L1 treatment and discuss their management. Read More

    Acute myeloid leukemia presenting as erythema nodosum: A case report.
    Medicine (Baltimore) 2017 Nov;96(47):e8666
    Department of Hematology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
    Rationale: Erythema nodosum (EN), a type of septal panniculitis, could be a rare nonspecific cutaneous presentation of acute myeloid leukemia (AML).

    Patient Concerns: A 58-year-old Chinese female was admitted for a 4-week history of painful cutaneous lesions, accompanied by a sternal pain and fever. The lesions once resolved spontaneously but then recurred. Read More

    Sweet syndrome-like cutaneous drug reaction.
    An Bras Dermatol 2017 Nov-Dec;92(6):858-860
    Department of Dermatology, Complexo Hospitalar Padre Bento de Guarulhos (CHPBG) - Guarulhos (SP), Brazil.
    Cutaneous drug reactions are adverse reactions to medications that may present with different clinical features, ranging from localized to generalized lesions. In this report we describe a case of an unusual drug reaction, resembling the morphology of Sweet syndrome lesions. The patient had a psychiatric illness and was using thioridazine hydrochloride for one year. Read More

    Lichen planus and lichenoid drug eruption after vaccination.
    Cutis 2017 Dec;100(6):E6-E20
    Harvard School of Public Health, Boston, Massachusetts, USA; and National Skin Centre, Singapore.
    Lichen planus (LP) and lichenoid drug eruptions (LDEs) uncommonly occur after vaccination, especially for hepatitis B and influenza. The key initiating event that leads to the development of postimmunization LP or LDE is not well understood. There have been prior reports of an association between several vaccines and LP. Read More

    Generalized Fixed Drug Eruption Induced by Fluconazole Without Cross-Reactivity to Itraconazole: Lymphocyte Transformation Test Confirms the Diagnosis.
    Drug Saf Case Rep 2018 Jan 2;5(1). Epub 2018 Jan 2.
    Division of Immunology and Allergic Diseases, Department of Internal Medicine, Istanbul Faculty of Medicine, Istanbul University, Millet Street, Capa, Istanbul, Turkey.
    We present a rare case of generalized fixed drug eruption caused by fluconazole. A 45-year-old female patient was referred to our outpatient clinic because of suspicious drug eruptions that occurred 5 months earlier and resolved within a month. The patient had sequela of hyperpigmentation on her arms, legs, back, and abdomen after oral administration of the fourth dose of 150 mg of fluconazole once daily because of vaginal candidiasis. Read More

    Fenofibrate-Induced Lichenoid Drug Eruption: A Rare Culprit.
    Case Rep Dermatol 2017 Sep-Dec;9(3):236-242. Epub 2017 Nov 14.
    Department of Rheumatology, Presence Saint Joseph Hospital, Chicago, Illinois, USA.
    A lichenoid drug eruption is a rare side effect which can occur following the administration of several different medications. Here we describe a unique case of fenofibrate as the causative agent of a lichenoid drug eruption. This case highlights a rare and clinically significant dermatologic side effect of fenofibrate. Read More

    Inflammatory dermatoses, infections, and drug eruptions are the most common skin conditions in hospitalized cancer patients.
    J Am Acad Dermatol 2017 Dec 19. Epub 2017 Dec 19.
    Dermatology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York; Department of Dermatology, Weill Cornell Medical College, New York, New York. Electronic address:
    Background: Dermatologic conditions cause morbidity and mortality among hospitalized cancer patients. An improved understanding is critical for implementing clinical and research programs in inpatient oncodermatology.

    Objective: To characterize inpatient dermatology consultations at a large comprehensive cancer center. Read More

    Deferasirox-induced urticarial vasculitis in a patient with myelodysplastic syndrome.
    An Bras Dermatol 2017 ;92(5 Suppl 1):59-61
    Department of Pathology, Mugla Sitki Kocman University, Faculty of Medicine - Mugla, Turkey.
    Deferasirox is an iron chelator agent used in the treatment of diseases with iron overload, such as thalassemia and myelodysplastic syndrome. Although the majority of adverse reactions of deferasirox involve gastrointestinal symptoms and increase in serum creatinine and transaminases, skin rashes, such as maculopapular and urticarial eruptions, have also been reported. This study reports a case of myelodysplastic syndrome with urticarial vasculitis due to deferasirox therapy. Read More

    Long-term mucocutaneous adverse effects of imatinib in Indian chronic myeloid leukemia patients.
    Int J Dermatol 2018 Mar 20;57(3):332-338. Epub 2017 Dec 20.
    Department of Hematology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
    Background: Short-term mucocutaneous adverse effects are well documented with imatinib. However, studies on long-term adverse effects and in the ethnic population are lacking.

    Objective: To study the long-term mucocutaneous adverse effects of imatinib and factors predicting these adverse effects. Read More

    Cutaneous Adverse Drug Reactions in a Tertiary Care Teaching Hospital in India: An Intensive Monitoring Study.
    Indian J Dermatol 2017 Nov-Dec;62(6):618-625
    Department of Skin and VD, GMERS Medical College, Gotri, Vadodara, Gujarat, India.
    Background: The epidemiological data based on intensive monitoring studies are limited for the cutaneous adverse drug reactions (CADRs) in terms of incidence. Most of earlier Indian studies focused only on types and causative drugs of CADRs.

    Aim: The aim of this study is to analyze the CADRs with reference to the incidence, its subgroup analysis, causative drugs, and other clinical characteristics in Indian population. Read More

    Hand-Foot Syndrome and Post-Progression Treatment Are the Good Predictors of Better Survival in Advanced Hepatocellular Carcinoma Treated with Sorafenib: A Multicenter Study.
    Oncology 2017 20;93 Suppl 1:113-119. Epub 2017 Dec 20.
    Department of Gastroenterology and Hepatology, Takamatsu Red Cross Hospital, Takamatsu, Japan.
    Objective: To determine the relationship between treatment outcomes and hand-foot syndrome (HFS), and the relationship between survival rate and post-progression treatment after sorafenib therapy.

    Methods: The study assessed 314 patients with advanced hepatocellular carcinoma (HCC) treated with sorafenib at 5 general hospitals in Kagawa Prefecture, Japan.

    Results: At the start of sorafenib therapy, 23. Read More

    Increased activated memory B-cells in the peripheral blood of patients with erythema nodosum leprosum reactions.
    PLoS Negl Trop Dis 2017 12 18;11(12):e0006121. Epub 2017 Dec 18.
    London School of Hygiene and Tropical Medicine (LSHTM), Faculty of Infectious Tropical Diseases, London, United Kingdom.
    B-cells, in addition to antibody secretion, have emerged increasingly as effector and immunoregulatory cells in several chronic inflammatory diseases. Although Erythema Nodosum Leprosum (ENL) is an inflammatory complication of leprosy, the role of B- cell subsets has never been studied in this patient group. Therefore, it would be interesting to examine the contribution of B-cells in the pathogenesis of ENL. Read More

    Bevacizumab-associated Sudden Onset of Multiple Monomorphic Comedones on the Scalp Successfully Treated with 30% Salicylic Acid Peels.
    Acta Dermatovenerol Croat 2017 Oct;25(3):245-247
    Eftychia Platsidaki, MD, 5 Ionos Dragoumi Str, 16121 Athens, Greece;
    Bevacizumab is a humanized monoclonal antibody against vascular endothelial factor (VEGF) that targets tumor cell angiogenesis and proliferation. Although it is usually well tolerated, many side-effects have been reported. These include hypertension, bleeding, and thromboembolic events among others. Read More

    Early cutaneous eruptions after oral hydroxychloroquine in a lupus erythematosus patient: A case report and review of the published work.
    J Dermatol 2018 Mar 14;45(3):344-348. Epub 2017 Dec 14.
    Department ofDermatology, Kansai Medical University, Hirakata, Japan.
    Hydroxychloroquine (HCQ) is an effective treatment of lupus erythematosus. Although adverse effects, mainly gastrointestinal and cutaneous manifestations, are rare, they may result in the cessation of medication in some patients with severe reactions. Therefore, the evaluation of a patient's condition is important for a dermatologist to decide whether to cease or continue HCQ. Read More

    How to identify DRESS, drug reaction with eosinophilia and systemic symptoms?
    Duodecim 2017;133(1):43-51
    DRESS (drug reaction with eosinophilia and systemic symptoms) is a rare, severe multiorgan adverse drug reaction. Antiepileptic age's and antibiotics are the most frequently reported causative agents. Compared with other drug reactions, DRESS demonstrates a long latency period thus complicating recognition and diagnosis. Read More

    Incidence of skin toxicity in squamous cell carcinoma of the head and neck treated with radiotherapy and cetuximab: A systematic review.
    Crit Rev Oncol Hematol 2017 Dec 31;120:98-110. Epub 2017 Oct 31.
    Radiation Oncology, Azienda Ospedaliero - Universitaria Careggi, University of Florence, Florence, Italy.
    Purpose: Radiotherapy plus cetuximab is an effective combination therapy for locally advanced head and neck squamous cell carcinoma. The aim of our study was to determine the frequency of skin toxicity in patients receiving the combined treatment.

    Results: Forty-eight studies were included in our analysis, for a total of 2152 patients. Read More

    Acute generalized exanthematous pustulosis induced by hydroxychloroquine: a case with atypical clinical presentation.
    An Bras Dermatol 2017 May-Jun;92(3):404-406
    Department of Pathology, Okmeydani Training and Research Hospital - Istanbul, Turkey.
    Acute generalized exanthematous pustulosis is a rare drug-induced eruption that is characterized by acute, nonfollicular sterile pustules on an erythematous and edematous base. The most frequently implicated drugs are beta-lactam antibiotics. Hydroxychloroquine has been widely used to treat dermatologic and rheumatologic diseases and has been reported as a rare cause of acute generalized exanthematous pustulosis. Read More

    Efficacy and safety of regorafenib in the treatment of metastatic colorectal cancer: A systematic review.
    Cancer Treat Rev 2018 Jan 10;62:61-73. Epub 2017 Nov 10.
    Department of Oncology, Herlev and Gentofte Hospital, University of Copenhagen, Herlev Ringvej 75, DK- 2730 Herlev, Denmark. Electronic address:
    Purpose: Despite advances in the treatment of colorectal cancer, third-line treatment options are still limited. Regorafenib was approved in 2012 for the treatment of patients with metastatic colorectal cancer previously treated with approved standard therapy. The purpose of this review is to present existing clinical data on regorafenib. Read More

    First experience in the UK of treating women with recurrent urinary tract infections with the bacterial vaccine Uromune.
    BJU Int 2018 02 23;121(2):289-292. Epub 2017 Nov 23.
    Royal Berkshire Hospital, Reading, UK.
    Objectives: To determine the effectiveness of Uromune in preventing recurrent urinary tract infections (UTIs) in women.

    Patients And Methods: A total of 77 women with microbiology-proven recurrent UTIs were given Uromune sublingual vaccine for a period of 3 months. Time to first UTI recurrence since treatment and adverse events were prospectively recorded in a follow-up period of up to 12 months. Read More

    Dyshidrosiform pemphigoid localized on the hands in a child: a rare occurrence.
    An Bras Dermatol 2017 Sep-Oct;92(5):714-716
    Pt. B. D. Sharma, Post Graduate Institute of Medical Sciences - Rohtak- Haryana, India.
    Dyshidrosiform pemphigoid is an acquired autoimmune variant of bullous pemphigoid with persistent vesicobullous eruptions localized on the palms or soles, or both. It generally occurs in the elderly and is rarely reported in childhood. Hereby, we describe the first case of dyshidrosiform pemphigoid in a 12-year-old child, which was limited to the dorsal hands and treated successfully with dapsone (diaminodiphenyl sulfone). Read More

    Stevens-Johnson syndrome and toxic epidermal necrolysis: epidemiological and clinical outcomes analysis in public hospitals.
    An Bras Dermatol 2017 Sep-Oct;92(5):661-667
    Stricto Sensu Postgraduate Program In Health Sciences of Fundação de Ensino e Pesquisa em Ciências da Saúde (FEPECS) - Brasília (DF), Brazil.
    Background: Adverse drug reactions are harmful and involuntary responses to drugs that occur at doses normally used for a given condition. Among them are Stevens-Johnson syndrome and toxic epidermal necrolysis, both rare and potentially fatal conditions.

    Objectives: To analyze the epidemiological and clinical characteristics related to patients diagnosed with Stevens-Johnson syndrome and toxic epidermal necrolysis in public hospitals in the Federal District - Brazil. Read More

    A pilot study evaluating biomarker development for drug-induced chronic eczematous eruptions of aging individuals.
    Ann Transl Med 2017 Oct;5(20):393
    Department of Dermatology, University of Utah School of Medicine, Salt Lake City, UT, USA.
    Background: Identifying the drug(s) responsible for drug-induced chronic eczematous eruptions of aging individuals (CEEA) is a clinical challenge in patients on multiple medications. Reliable testing methods and biomarkers are needed to identify the causative agent and allow simultaneous assessment of T-cell responses to multiple drugs being taken concurrently. This study examined the feasibility of using , drug-specific T cell activation responses as a biomarker for drug-induced CEEA. Read More

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