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    1 OF 463

    Autoimmune progesterone dermatitis presenting as fixed drug eruption: a case report.
    Dermatol Online J 2017 Jun 15;23(6). Epub 2017 Jun 15.
    Molecular Dermatology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
    Autoimmune progesterone dermatitis (APD) is a rare disorder characterized by periodic skin lesions that erupt during the luteal phase of the menstrual cycle. Clinical manifestations of APD is caused by an unusual allergy to progesterone and has a wide range of clinical manifestations from eczema and urticaria to angioedema and erythema multiforme. A 46-year-old woman described recurrent, round erythematous plaques on the lower lip, both forearms and buttocks. Read More

    Angioimmunoblastic T-Cell Lymphoma Mimicking Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS Syndrome).
    Case Rep Dermatol 2017 Jan-Apr;9(1):74-79. Epub 2017 Mar 21.
    aDepartment of Dermatology, University Hospital Zurich, Zurich, Switzerland.
    Angioimmunoblastic T-cell lymphoma (AITCL) is a rare, aggressive lymphoma which derives from follicular helper T cells, commonly affecting the elderly population. It accounts for 2% of all non-Hodgkin lymphomas, with a reported 5-year overall survival rate of less than 30%. Very often, the clinical picture of AITCL encompasses systemic symptoms such as generalized lymphadenopathy, hepatosplenomegaly, skin rash, anemia, and polyclonal hypergammaglobulinemia. Read More

    Misuse of Topical Corticosteroids over Face: A Clinical Study.
    Indian Dermatol Online J 2017 May-Jun;8(3):186-191
    Department of Dermatology, Swami Dayanand Hospital, New Delhi, India.
    Introduction: Topical corticosteroids (TCS) have been widely used in various dermatological diseases. However, because of inadvertent use, TCS misuse has become a common problem faced by dermatologists in various parts of the world. Prolonged use over the face can cause various side effects such as steroid rosacea, acneiform eruptions, and hypertrichosis. Read More

    Adjuvant Capecitabine for Breast Cancer after Preoperative Chemotherapy.
    N Engl J Med 2017 06;376(22):2147-2159
    From the National Hospital Organization Osaka National Hospital, Osaka (N.M.), Hiroshima City Hiroshima Citizens Hospital, Hiroshima (S. Ohtani), Kyoto Prefectural University of Medicine (I.Y.), and Graduate School of Medicine, Kyoto University (M.T.), Kyoto, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital (K.K.), and Chuo University (Y.O.), Tokyo, Gunma Prefectural Cancer Center, Ota (Y.Y.), National Hospital Organization Kyushu Cancer Center, Fukuoka (S. Ohno), Hyogo Cancer Center, Akashi (S.T.), National Hospital Organization Shikoku Cancer Center, Matsuyama (K.A.), Aichi Cancer Center Hospital, Nagoya (H.I.), and Tohoku University, Sendai (H.S.) - all in Japan; and Yeungnam University Hospital, Daegu (S.-J.L.), Samsung Medical Center, Sungkyunkwan University School of Medicine (Y.-H.I.), Cancer Research Institute, Seoul National University Hospital, Seoul National University College of Medicine (S.-A.I.), Severance Hospital (B.-W.P.) and Gangnam Severance Hospital (J.J.), Yonsei University College of Medicine, Asan Medical Center, University of Ulsan College of Medicine (S.-B.K.), Korea University Guro Hospital (A.K.), and Korea University Anam Hospital (K.-H.P.), Seoul, and National Cancer Center, Goyang-si (E.-S.L.) - all in South Korea.
    Background: Patients who have residual invasive carcinoma after the receipt of neoadjuvant chemotherapy for human epidermal growth factor receptor 2 (HER2)-negative breast cancer have poor prognoses. The benefit of adjuvant chemotherapy in these patients remains unclear.

    Methods: We randomly assigned 910 patients with HER2-negative residual invasive breast cancer after neoadjuvant chemotherapy (containing anthracycline, taxane, or both) to receive standard postsurgical treatment either with capecitabine or without (control). Read More

    Isolated Actinic Lichen Planus of the Lower Lip.
    Case Rep Dermatol 2017 Jan-Apr;9(1):131-134. Epub 2017 Apr 27.
    National University Hospital, Singapore, Singapore.
    Oral lichen planus (LP) is a common manifestation in patients with LP; however, isolated lip LP is rare and may mimic other conditions such as lichenoid drug eruptions, actinic cheilitis, and early carcinoma in situ in the absence of typical skin lesions. Actinic lichen planus (ALP) is a variant of LP occurring on light-exposed areas in patients with dark skin. We report the case of a Chinese female with isolated ALP of the lower lip, mimicking herpes simplex infection at presentation. Read More

    Fuchs Syndrome: Medical Treatment of 1 Case and Literature Review.
    Case Rep Dermatol 2017 Jan-Apr;9(1):114-120. Epub 2017 Apr 18.
    Department of Odontology, University Hospital of Montpellier, Montpellier, France.
    Fuchs syndrome is a particular type of erythema multiforme major; the lesions are only found on the mucosae and specifically affect oral, ocular, and genital mucosae. The cause is not always immediately apparent, which is why this pathology requires a rigorous, detailed clinical examination to eliminate a differential diagnosis. The severity of the symptoms, particularly of oral and ocular symptoms, requires immediate treatment. Read More

    A Dissimilar Biosimilar?: Lichenoid Drug Eruption Induced by an Infliximab Biosimilar.
    Br J Dermatol 2017 May 30. Epub 2017 May 30.
    Dermatology, Icahn School of Medicine at Mount Sinai, New York, United States.
    The advent of therapeutic antibodies, or biologic medications, has transformed our treatment of many inflammatory diseases in dermatology. Recently, the development of biosimilars, biologic drugs that are highly similar in quality, safety, and efficacy to approved biologics, has changed this landscape. Although biosimilars are not identical to their reference product, they are required to have the same mechanism of action, route of administration, dosage form, and strength as the reference product. Read More

    Lichenoid Drug Eruption with Prominent Nail Changes Due to Leflunomide in a 12-Year-Old Child.
    Pediatr Dermatol 2017 May 23. Epub 2017 May 23.
    Division of Dermatology, Department of Pediatrics, School of Medicine, Seattle Children's Hospital, University of Washington, Seattle, Washington.
    We present the case of a 12-year-old-girl who developed lichenoid dermatitis approximately 1 year after starting leflunomide for juvenile idiopathic arthritis. The eruption resolved promptly with discontinuation of the suspected culprit agent, supportive of a lichenoid drug eruption, but she subsequently developed markedly dystrophic nails with lichen planus-like features. A biopsy of her cutaneous findings at the time of initial presentation demonstrated lichenoid dermatitis, and a nail matrix biopsy was deferred given clinical correlation. Read More

    Purpuric Drug Eruptions Caused by Epidermal Growth Factor Receptor Inhibitors for Non-Small Cell Lung Cancer: A Clinicopathologic Study of 32 Cases.
    JAMA Dermatol 2017 May 24. Epub 2017 May 24.
    Department of Dermatology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.
    Importance: Purpuric skin lesions have only rarely been reported in patients receiving epidermal growth factor receptor inhibitors. However, their clinical and histopathologic presentations have varied considerably.

    Objective: To characterize purpuric skin eruptions caused by epidermal growth factor receptor inhibitors. Read More

    [Epicutaneous patch testing in delayed drug hypersensitivity reactions induced by antiepileptic drugs].
    Therapie 2017 Mar 25. Epub 2017 Mar 25.
    Centre régional de pharmacovigilance de Sfax, faculté de médecine de Sfax, avenue Majida-Boulila, 3029 Sfax, Tunisie.
    Introduction: Antiepileptic drugs are widely used and are associated with numerous side effects including skin eruptions. Epicutaneous tests have been used with variable success in skin drug reactions. The purpose of this study was to evaluate the profitability of epicutaneous tests in delayed hypersensitivity reactions induced by antiepileptic drugs. Read More

    Minocycline-Induced Hyperpigmentation in a Patient Treated with Erlotinib for Non-Small Cell Lung Adenocarcinoma.
    Case Rep Oncol 2017 Jan-Apr;10(1):156-160. Epub 2017 Feb 15.
    Walter Reed National Military Medical Center, Bethesda, MD, USA.
    Introduction: While epidermal growth factor receptor (EGFR) inhibitors have improved progression-free survival in patients with non-small cell lung cancer (NSCLC), one of the most common adverse effects is papulopustular skin eruption, which is frequently severe enough to be treated with oral minocycline or doxycycline.

    Case: We present a case of an 87-year-old man who developed a severe papulopustular skin eruption secondary to erlotinib therapy for NSCLC. Control of the eruption with 100 mg of minocycline twice daily for 8 months eventually led to blue-gray skin hyperpigmentation. Read More

    Viral exanthems: An update on laboratory testing of the adult patient.
    J Am Acad Dermatol 2017 Mar 26;76(3):538-550. Epub 2016 Oct 26.
    Division of Dermatology, Department of Internal Medicine, Ohio State University Comprehensive Cancer Center, Columbus, Ohio. Electronic address:
    Although classic viral exanthems of childhood are well described, they are rarely differentiated in adults. Laboratory techniques for viral identification have advanced without substantial literature to suggest how a dermatologist ought to conduct a cost-effective and diagnostic viral panel. Certain clinical features such as petechiae, vesicles, and dusky macular or morbilliform exanthems point strongly toward a viral exanthem. Read More

    Fever in Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in Pediatric Cases: Laboratory Work-up and Antibiotic Therapy.
    Pediatr Infect Dis J 2017 May;36(5):513-515
    From the Department of Dermatology, Dokumentationszentrum schwerer Hautreaktionen (dZh), Medical Center-University of Freiburg, Hauptstrasse 7, 79104 Freiburg, Germany.
    Fever is a symptom that often accompanies skin eruptions, especially in children. It can be a sign of an infectious condition presenting with exanthems or it may precede an exanthematous eruption. Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are severe reactions affecting skin and mucosa with blisters and erosions. Read More

    Treatment of Human Scabies with Oral Ivermectin. Eczematous Eruptions as a New Non-Reported Adverse Event.
    Actas Dermosifiliogr 2017 Apr 3. Epub 2017 Apr 3.
    Department of Dermatology, Hospital Universitario La Princesa, Spain.
    Background: Oral ivermectin is an alternative therapy for human scabies infection due to its ease of administration and good safety profile. However, there is no definitive consensus on the optimal dosing regimen.

    Objective: To describe the treatment of human scabies with different dosages of oral ivermectin and the possible adverse events. Read More

    [Toxic epidermal necrolysis (Lyell syndrome), a lifethreatening emergency of introgenic origin].
    Rev Med Liege 2016 Oct;71(10):435-439
    Service de Dermatologie, CHU de Liège, site du Sart Tilman, Liège, Belgique.
    Cutaneous drug eruptions are frequently encoun¬tered. Their putative diagnosis is based on a set of imputability arguments. The histopathological aspect is often suggestive of the dermatosis nature, and varies according to the type of drug reaction. Read More

    Non-immediate Cutaneous Reactions to Beta-Lactams: Approach to Diagnosis.
    Curr Allergy Asthma Rep 2017 Apr;17(4):23
    Allergy Unit, Presidio Columbus, Via G. Moscati, 31, 00168, Rome, Italy.
    Non-immediate cutaneous reactions (i.e., occurring at least 1 h after the initial drug administration), particularly maculopapular exanthemas and urticarial eruptions, are common during beta-lactam treatments. Read More

    Cutaneous Manifestations of Diabetes Mellitus: A Review.
    Am J Clin Dermatol 2017 Apr 3. Epub 2017 Apr 3.
    Department of Dermatology, University Hospital Jena, Erfurter Straße 35, 07740, Jena, Germany.
    Diabetes mellitus is a widespread endocrine disease with severe impact on health systems worldwide. Increased serum glucose causes damage to a wide range of cell types, including endothelial cells, neurons, and renal cells, but also keratinocytes and fibroblasts. Skin disorders can be found in about one third of all people with diabetes and frequently occur before the diagnosis, thus playing an important role in the initial recognition of underlying disease. Read More

    Syphilis: Re-emergence of an old foe.
    Microb Cell 2016 Jun 27;3(9):363-370. Epub 2016 Jun 27.
    Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7435.
    Syphilis is caused by infection with Treponema pallidum subsp. pallidum, a not-yet-cultivable spiral-shaped bacterium that is usually transmitted by sexual contact with an infected partner or by an infected pregnant woman to her fetus. There is no vaccine to prevent syphilis. Read More

    Pharmacologic Impact (aka "Breaking Bad") of Medications on Wound Healing and Wound Development: A Literature-based Overview.
    Ostomy Wound Manage 2017 Mar;63(3):18-35
    School of Nursing-Camden, Rutgers University, Camden, NJ.
    Patients with wounds often are provided pharmacologic interventions for their wounds as well as for their acute or chronic illnesses. Drugs can promote wound healing or substantively hinder it; some medications cause wound or skin reactions. A comprehensive review of extant literature was conducted to examine the impact of drug therapy on wound healing and skin health. Read More

    Generalized bullous fixed drug eruption treated with cyclosporine.
    Dermatol Online J 2017 Feb 15;23(2). Epub 2017 Feb 15.
    Department of Dermatology, University of Texas Southwestern Medical Center.
    Fixed drug eruptions (FDE) comprise 10 percent of alladverse cutaneous drug reactions and generalizedbullous fixed drug eruptions (GBFDE) are a raresubset of FDEs. We present a patient with severeGBFDE caused by ibuprofen successfully treated withcyclosporine. Further work is needed to determine ifcyclosporine can be an effective therapy for GBFDE. Read More

    Capecitabine-induced lichenoid drug eruption: a case report.
    Dermatol Online J 2017 Feb 15;23(2). Epub 2017 Feb 15.
    Richard L. Roudebush VA Medical Center, Indianapolis, Indiana.
    Capecitabine is a 5-fluorouracil basedchemotherapeutic drug widely used in the treatmentof solid tumors, especially colorectal and breast. Someof the most common side effects of capecitabine arecutaneous in nature, including hand-foot syndrome(palmar-plantar erythrodysesthesia). Several reports inthe literature link capecitabine use with photosensitivelichenoid eruptions. Read More

    Certolizumab-induced guttate psoriasiform dermatitis.
    Dermatol Online J 2017 Jan 15;23(1). Epub 2017 Jan 15.
    Division of Dermatology, University of Kansas Medical Center, Kansas City.
    Certolizumab is a TNF inhibitor that has showngreat efficacy in chronic inflammatory diseases. Wereport a patient exhibiting a novel adverse effect ofcertolizumab: drug-induced guttate psoriasiformeruption. A review of the mechanism of psoriasiformdrug eruptions is also included. Read More

    Difficult clinical management of antituberculosis DRESS syndrome complicated by MRSA infection: A case report.
    Medicine (Baltimore) 2017 Mar;96(11):e6346
    Department of Dermatology, Allergy and Clinical Immunology Centre, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
    Rationale: Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a severe drug-induced hypersensitivity reaction characterized by skin rash, fever, blood abnormalities, and multiple organ involvement. The diagnosis of DRESS syndrome is often delayed because of its variable presentation. Prompt withdrawal of the culprit drug is the definitive treatment. Read More

    Adult-onset Still's disease with atypical cutaneous manifestations.
    Medicine (Baltimore) 2017 Mar;96(11):e6318
    aDepartment of Rheumatology bDepartment of Dermatology, Hospital Universitario de Bellvitge-IDIBELL, Barcelona, Spain.
    The diagnosis of adult-onset Still's disease (AOSD) can be very difficult. There are no specific tests available, and diagnosis is usually based on a symptom complex and the well-described typical evanescent rash seen in the majority of patients. However, in recent years, other atypical cutaneous manifestations of AOSD have been reported. Read More

    A Case of Cycloserine-Induced Lichenoid Drug Eruption Supported by the Lymphocyte Transformation Test.
    Allergy Asthma Immunol Res 2017 May;9(3):281-284
    Department of Internal Medicine, Kangwon National University Hospital, Chuncheon, Korea.
    Lichenoid drug eruption (LDE) is a rare form of delayed-type drug eruption. Among anti-tuberculosis (Tb) agents, cycloserine (CS) has been reported as a rare cause of LDE. Positive results on the lymphocyte transformation test (LTT) have not been reported in patients with LDE. Read More

    Long-term results of therapy with sunitinib in metastatic alveolar soft part sarcoma.
    Tumori 2017 May 8;103(3):231-235. Epub 2017 Mar 8.
    Department of Soft Tissue/Bone Sarcoma and Melanoma, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw - Poland.
    Background: Alveolar soft part sarcoma (ASPS) is a rare, highly vascularized soft tissue sarcoma characterized by a high frequency of metastatic disease and resistance to classical chemotherapy. The purpose of our analysis was to assess long-term sunitinib activity in the treatment of metastatic ASPS.

    Patients And Methods: Between 2009 and 2015, 15 patients were diagnosed with metastatic ASPS and received therapy with sunitinib at initial continuous daily dosing of 37. Read More

    Pediatric Stevens-Johnson syndrome and toxic epidermal necrolysis in the United States.
    J Am Acad Dermatol 2017 May 9;76(5):811-817.e4. Epub 2017 Mar 9.
    Department of Dermatology, Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, Illinois; Department of Dermatology, Northwestern University Feinberg School of Medicine, Chicago, Illinois. Electronic address:
    Background: Little is known about the epidemiology of Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) in children.

    Objective: We sought to determine the morbidity, mortality, and comorbid health conditions of SJS and TEN in US children.

    Methods: This was a cross-sectional study of the 2009 to 2012 Nationwide Inpatient Sample, which contains a representative 20% sample of all US hospitalizations. Read More

    Human Leukocyte Antigen Class I Genes Associated With Stevens-Johnson Syndrome and Severe Ocular Complications Following Use of Cold Medicine in a Brazilian Population.
    JAMA Ophthalmol 2017 Apr;135(4):355-360
    Department of Frontier Medical Science and Technology for Ophthalmology, Kyoto, Prefectural University of Medicine, Kyoto, Japan.
    Importance: Describing the association with human leukocyte antigen (HLA) alleles could facilitate the understanding of increased risk factors for development of Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) in patients with severe ocular complications (SOCs).

    Objective: To investigate the association between HLA class I genes and cold medicine (CM)-associated SJS/TEN with SOCs.

    Design, Setting, And Participants: This case-control study was conducted between February 8, 2013, and August 29, 2014. Read More

    The role of dermatopathology in inpatient care.
    Semin Cutan Med Surg 2017 Mar;36(1):17-22
    Department of Dermatology, University of Minnesota Medical Center, Minneapolis, Minnesota, USA.
    Skin biopsy remains one of the most important tools in the evaluation of dermatologic disease in hospitalized patients and is diagnostic for many common inpatient dermatoses, including various drug eruptions and cutaneous infections. The dermatopathology team thus plays a crucial role in the care of many of these patients and can add significant value through timely and precise diagnoses. Here, we review the unique challenges of dermatopathology in hospital-based medicine, discuss approaches to timely care, and examine effective clinicopathologic correlation in this setting. Read More

    Antithyroid arthritis syndrome.
    BMJ Case Rep 2017 Feb 27;2017. Epub 2017 Feb 27.
    Department of Endocrinology, Cooper University Hospital, Camden, New Jersey, USA.
    Antithyroid arthritis syndrome is a constellation of symptoms of myalgia, arthralgia, arthritis, fever and rash associated with the use of antithyroid medications. We report a case of a patient with severe hyperthyroidism likely secondary to Graves' disease who presented with the abovementioned symptoms after being treated with methimazole (antithyroid medication). Our aim is to increase awareness regarding this uncommon but disabilitating and life-threatening adverse effect of antithyroid medications among clinicians. Read More

    Prostaglandin E1 reduces the keratinocyte toxicity of sorafenib by maintaining signal transducer and activator of transcription 3 (STAT3) activity and enhancing the cAMP response element binding protein (CREB) activity.
    Biochem Biophys Res Commun 2017 Apr 24;485(2):227-233. Epub 2017 Feb 24.
    Division of Pharmaceutics, Department of Internal Related, Kobe University Graduate School of Medicine, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan; Department of Pharmacy, Kobe University Hospital, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan.
    Hand-foot skin reaction (HFSR) is a common side effect of multiple tyrosine kinase inhibitors (mTKIs). HFSR can necessitate dose reductions or interruption of therapy owing to its negative effect on the quality of life. Therefore, effective use of mTKIs requires measures to prevent HFSR. Read More

    The Impact of Early Dermatologic Events in the Survival of Patients with Hepatocellular Carcinoma Treated with Sorafenib.
    Ann Hepatol 2017 March-April;16(2):263-268
    Irmandade Santa Casa de Misericórdia de Porto Alegre Hospital, Department of Hepatology, Federal University of Health Sciences of Porto Alegre, Brazil.
    Background And Aims: The presence of dermatologic reaction as an adverse event to sorafenib treatment in patients with unresectable hepatocellular carcinoma has been indicated as a prognostic factor for survival in a recent prospective analysis. To date, this is the only clinical predictor of treatment response, which can be evaluated earlier in the treatment and, therefore, contribute to a better and more individualized patient management.

    Material And Methods: This retrospective study included 127 patients treated with sorafenib under real-life practice conditions in two hepatology reference centers in Brazil. Read More

    Common Skin Conditions in Children: Noninfectious Rashes.
    FP Essent 2017 Feb;453:18-25
    University of North Carolina Chapel Hill School of Medicine Dermatology Residency Program, 410 Market St. Suite 400 CB#7715, Chapel Hill, NC 27516.
    Cutaneous adverse drug reactions are among the most common noninfectious rashes of childhood. Cutaneous adverse drug reactions are classified as morbilliform, urticarial, bullous, pustular, or psoriasiform. Atopic dermatitis is one of the most common inflammatory cutaneous eruptions, and is characterized by pruritus and flexural distribution. Read More

    Metronidazole and Norfloxacin induced Generalized Fixed Drug Eruptions in an adult male patient - A Case Report.
    Curr Drug Saf 2017 Feb 9. Epub 2017 Feb 9.
    Government Medical College and Sir Takhtsinhji General Hospital,India.
    Introduction: Fluoroquinolones are most widely used for empirical treatment of gastrointestinal disease due to emergence of drug resistant strains to other antimicrobials. They are also indulged in cutaneous adverse drug reactions with varying form of severity.

    Case Presentation: A 43 year old male patient developed fixed drug eruptions after administration of tablet norfloxacin and metronidazole for treatment of colicky abdominal pain with diarrhoea. Read More

    Janus kinase inhibitors in dermatology: A systematic review.
    J Am Acad Dermatol 2017 Apr 4;76(4):745-753.e19. Epub 2017 Feb 4.
    Department of Dermatology, Hadassah - Hebrew University Medical Center, Jerusalem, Israel. Electronic address:
    Background: Janus kinase (JAK) inhibitors are emerging as a promising new treatment modality for many inflammatory conditions.

    Objective: Our aim was to systematically review the available data on the use of JAK inhibitors in cutaneous diseases.

    Methods: This is a systematic review of PubMed and ClinicalTrials. Read More

    Risk of cumulative toxicity after complete melanoma response with pembrolizumab.
    BMJ Case Rep 2017 Feb 1;2017. Epub 2017 Feb 1.
    Department of Medical Oncology, Royal Adelaide Hospital, Adelaide, South Australia, Australia.
    Pembrolizumab is an approved first-line systemic therapy for unresectable metastatic melanoma. Despite the achievement of complete and durable responses in a small subgroup of patients, it is standard practice that pembrolizumab therapy continues beyond complete response. Nevertheless, the incidence of immune-related toxicities gradually increases with continuing pembrolizumab therapy. Read More

    The metabolism of methazolamide in immortalized human keratinocytes, HaCaT cells.
    Drug Metab Lett 2017 Jan 27. Epub 2017 Jan 27.
    Department of Ophthalmology, Osaka Prefectural Medical Center for Respiratory and Allergic Diseases, 3-7-1 Habikino, Habikino-shi Osaka 583-8588, Japan.
    Objective: Drug therapy is occasionally accompanied by an idiosyncratic severe toxicity, which occurs very rarely, but can lead to patient mortality. Methazolamide, an anti-glaucomatous agent, could cause severe skin eruptions called Stevens-Johnson syndrome/toxic epidermal necrolyis (SJS/TEN). Its precise etiology is still uncertain. Read More

    Lichenoid Dermatologic Toxicity From Immune Checkpoint Blockade Therapy: A Detailed Examination of the Clinicopathologic Features.
    Am J Dermatopathol 2017 Feb;39(2):121-129
    *Department of Pathology, Section of Dermatopathology, The University of Texas MD Anderson Cancer Center, Houston, TX; Departments of †Dermatology, and ‡Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX.
    Immunotherapy targeting the programmed cell death 1 (PD-1) receptor has demonstrated tremendous promise in the treatment of advanced solid tumors. Dermatologic toxicities, however, are an emerging consequence of this therapy and have been clearly associated with immune checkpoint blockade antibodies. Distinctive clinical and histologic subtypes of dermatologic toxicity secondary to immunotherapy are emerging and include rare autoimmune bullous reactions (eg, bullous pemphigoid) and lichenoid eruptions. Read More

    Cutaneous Reactions to Targeted Therapy.
    Am J Dermatopathol 2017 Feb;39(2):67-82
    *Dermatology Resident, University of Pittsburg Medical Center, Pittsburg, PA; Associate Professor, Departments of †Pathology, and ‡Dermatology, Massachusetts General Hospital, Boston, MA; and §Associate Professor, Harvard Medical School, Boston, MA.
    Over the past decade, numerous targeted therapeutic agents have become available for clinical use in the oncologic setting with the hopes of realizing personalized cancer treatment. These agents have achieved great improvements in clinical outcomes for patients suffering from solid and hematologic malignancies. However, adverse cutaneous reactions are among the most common toxicities observed in patients undergoing treatment with a targeted agent and can alter the overall clinical management strategy. Read More

    A Review of the Pathogenesis of Toxic Epidermal Necrolysis.
    J Nippon Med Sch 2016 ;83(6):216-222
    Department of Dermatology, Nippon Medical School.
    Toxic epidermal necrolysis (TEN) is a rare skin condition, most often drug-induced, known for its skin detachment and high mortality. In general, acute TEN is considered a T-cell mediated, type IV hypersensitivity disorder. It mostly results from a cumulative effect of risks from the drug structure, drug metabolism, HLA alleles and T cell clonotypes. Read More

    Rumpel-Leede phenomenon in a patient with adult-onset Still's disease.
    BMJ Case Rep 2017 Jan 27;2017. Epub 2017 Jan 27.
    George Washington University School of Medicine and Health Sciences, Stouffville, Ontario, Canada.
    Rumpel-Leede phenomenon (RLP), also known as acute capillary rupture syndrome (ACRS), is a rare occurrence where distal dermal capillaries rupture in response to a proximal compressive force, such as a blood pressure cuff or tourniquet. This phenomenon has been reported to occur in states of vascular fragility such as long-term steroid use, hypertension or diabetes mellitus. Here, we provide a report of RLP occurring secondary to tourniquet application in a 26-year-old woman with adult-onset Still's disease (AOSD) and a recent drug rash. Read More

    Anticonvulsant hypersensitivity syndrome secondary to carbamazepine.
    Proc (Bayl Univ Med Cent) 2017 Jan;30(1):94-96
    Department of Internal Medicine, Baylor Scott & White Hospital, Temple, Texas.
    Anticonvulsant hypersensitivity syndrome (AHS) is a potentially fatal multiorgan drug reaction that presents with various cutaneous eruptions. There is a genetic predisposition to such reactions. We present a young woman with AHS due to carbamazepine that presented as an atypical erythema multiforme with elevated liver enzymes. Read More

    Nicolau Syndrome.
    Arch Iran Med 2017 Jan;20(1):60-64
    Department of Clinical Pharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
    A 23 year-old man was admitted to the hospital with chief complaints of pain, edema and spasm of the left lower limb, as well as mottling of dorsal and plantar aspects of the foot.  One week before the current admission, he was treated with oral co-amoxiclave and intramuscular penicillin 6.3. Read More

    Management of acute skin toxicity with Hypericum perforatum and neem oil during platinum-based concurrent chemo-radiation in head and neck cancer patients.
    Med Oncol 2017 Feb 18;34(2):30. Epub 2017 Jan 18.
    Department of Oncology, Radiation Oncology, University of Turin, Via Genova 3, 10126, Turin, Italy.
    Acute skin toxicity is a frequent finding during combined radiotherapy and chemotherapy in head and neck cancer patients. Its timely and appropriate management is crucial for both oncological results and patient's global quality of life. We herein report clinical data on the use of Hypericum perforatum and neem oil in the treatment of acute skin toxicity during concurrent chemo-radiation for head and neck cancer. Read More

    Genome-wide association study using the ethnicity-specific Japonica array: identification of new susceptibility loci for cold medicine-related Stevens-Johnson syndrome with severe ocular complications.
    J Hum Genet 2017 Apr 19;62(4):485-489. Epub 2017 Jan 19.
    Department of Human Genetics, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.
    A genome-wide association study (GWAS) for cold medicine-related Stevens-Johnson syndrome (CM-SJS) with severe ocular complications (SOC) was performed in a Japanese population. A recently developed ethnicity-specific array with genome-wide imputation that was based on the whole-genome sequences of 1070 unrelated Japanese individuals was used. Validation analysis with additional samples from Japanese individuals and replication analysis using samples from Korean individuals identified two new susceptibility loci on chromosomes 15 and 16. Read More

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