24,558 results match your criteria Drug Eruptions


The rash that becomes an erythroderma.

Clin Dermatol 2019 Mar - Apr;37(2):88-98. Epub 2018 Dec 5.

Department of Dermatology, Venereology & Leprosy, ESI Medical College & Hospital, Bengaluru, Karnataka, India.

Erythroderma is a dermatologic emergency with potentially serious consequences. Several diseases with different etiologies characteristically appear as erythroderma. Depending on the age groups, congenital ichthyosiform disorders, infections, preexisting dermatoses, drug eruptions, and internal malignancies commonly present with, or progress to, erythroderma. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0738081X183025
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http://dx.doi.org/10.1016/j.clindermatol.2018.12.002DOI Listing
December 2018
2 Reads

Paradoxical Skin Reactions to Biologics in Patients With Rheumatologic Disorders.

Front Pharmacol 2019 26;10:282. Epub 2019 Mar 26.

UOC Dermatologia, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.

Targeted immune-modulating treatment with biological agents has revolutionized the management of immune-mediated inflammatory diseases, including rheumatologic conditions. The efficacy and tolerability of biological agents, from the initial tumour necrosis factor (TNF)-α inhibitors to the new anti-cytokine monoclonal antibodies, have dramatically changed the natural history of debilitating conditions such as rheumatoid arthritis and seronegative spondyloarthropathies. The widening use of biologics across several rheumatologic diseases has been associated with a new class of adverse events, the so-called paradoxical reactions. Read More

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http://dx.doi.org/10.3389/fphar.2019.00282DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443901PMC
March 2019
2 Reads

Multi-organ failure induced by Nivolumab in the context of allo-stem cell transplantation.

Exp Hematol Oncol 2019 28;8. Epub 2019 Mar 28.

1Institute for Advanced Biosciences, Université Grenoble Alpes, INSERM 1209, UMR CNRS 5309, Grenoble, France.

Background: Immune checkpoint inhibitors have radically changed the landscape of anti-tumor therapies in several malignancies. However the adverse events associated with immune checkpoint blockade in combination with other treatments remains to be thoroughly documented. Here we report the case of a 33-year-old male with classical Hodgkin lymphoma who was successfully treated for lymphoma but experienced serious and eventually fatal multisystem organ failure following nivolumab administration and allogeneic stem cell transplantation. Read More

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http://dx.doi.org/10.1186/s40164-019-0132-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437980PMC
March 2019
1 Read

Investigating Nonimmediate Drug Eruptions: Diagnostic Benefit of a Structured Approach.

Authors:
Timothy J Watts

J Allergy Clin Immunol Pract 2019 Apr;7(4):1324-1326

Department of Adult Allergy, Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.jaip.2018.11.002DOI Listing
April 2019
1 Read

Hypersensitivity reactions to antiepileptic drugs in children.

Pediatr Allergy Immunol 2019 Apr 5. Epub 2019 Apr 5.

University of Belgrade-Faculty of Medicine, Belgrade, Serbia.

Background: Antiepileptic drugs (AEDs) can cause hypersensitivity reactions in children. These reactions are mainly cutaneous, self-limiting and benign but life-threatening severe cutaneous adverse reactions can occur. Infections can lead to skin eruptions and mimic drug hypersensitivity reactions, if a drug is taken at the same time. Read More

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http://dx.doi.org/10.1111/pai.13055DOI Listing
April 2019
2 Reads

Dermatological diseases in the geriatric age group: Retrospective analysis of 7092 patients.

Authors:
Mahizer Yaldiz

Geriatr Gerontol Int 2019 Apr 5. Epub 2019 Apr 5.

Department of Dermatology, Sakarya Training and Research Hospital, Sakarya, Turkey.

Aim: The aim of the present study was to retrospectively investigate the dermatological diseases seen in geriatric patients, and their distribution according to age, sex and season, making a significant contribution to the few previous prevalence studies.

Methods: Data from 7092 geriatric patients examined at our dermatology clinic from 1 January to 31 December 2017 were retrospectively analyzed. The data were analyzed according to age, sex and seasons. Read More

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http://dx.doi.org/10.1111/ggi.13665DOI Listing
April 2019
3 Reads

Cutaneous toxicities of antineoplastic agents: data from a large cohort of Greek patients.

Support Care Cancer 2019 Mar 27. Epub 2019 Mar 27.

Dermato-Oncology Department, Cutaneous Toxicities Clinic, Andreas Sygros Hospital, National and Kapodistrian University of Athens, Athens, Greece.

Purpose: Cutaneous toxicities from novel anticancer treatments are an emerging problem in dermato-oncology. However, the prevalence of those toxicities and necessity of skin consultations are currently unknown. The purpose of our study was to perform an epidemiologic analysis of cutaneous toxicities that were referred to our cutaneous toxicity clinic in Athens, Greece. Read More

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http://link.springer.com/10.1007/s00520-019-04751-y
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http://dx.doi.org/10.1007/s00520-019-04751-yDOI Listing
March 2019
3 Reads

Anaphylactic shock due to patent blue: case report and review of literature.

Pan Afr Med J 2018 4;31. Epub 2018 Sep 4.

Service de Gynéco-Obstétrique Monastir CMNM 5000 Monastir, Tunisia.

Intraoperative search for the sentinal node using patent blue is considered a non risk procedure. We emphasize the highly exceptional nature of this adverse effect previously observed in other disciplines using this coloring agent. We present a case of allergic reaction to patent blue in a patient who underwent left mastectomy with sentinel lymph node. Read More

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http://www.panafrican-med-journal.com/content/article/31/7/f
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http://dx.doi.org/10.11604/pamj.2018.31.7.15576DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6430938PMC
April 2019
5 Reads

Dermatology inpatient consultations in Latin America: 3-year experience in our University Hospital setting.

Int J Dermatol 2019 Mar 19. Epub 2019 Mar 19.

Hospital Universitario "Dr. José Eleuterio González", Universidad Autónoma de Nuevo León, Monterrey, Nuevo León, México.

Background: Dermatology patients are mostly seen in outpatient clinics; however, there is a significant need for consultations within the hospital setting.

Methods: Here we describe the hospital consultations received by the Dermatology Service during a 3-year period.

Results: Most of the requested consultations came from the Internal Medicine Department and the surgical departments. Read More

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http://dx.doi.org/10.1111/ijd.14418DOI Listing
March 2019
5 Reads

Drug-Induced Photosensitivity-An Update: Culprit Drugs, Prevention and Management.

Drug Saf 2019 Mar 19. Epub 2019 Mar 19.

Division of Dermatology, Department of Medicine, University of Toronto, Toronto, ON, Canada.

Photosensitive drug eruptions are cutaneous adverse events due to exposure to a medication and either ultraviolet or visible radiation. In this review, the diagnosis, prevention and management of drug-induced photosensitivity is discussed. Diagnosis is based largely on the history of drug intake and the appearance of the eruption primarily affecting sun-exposed areas of the skin. Read More

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http://dx.doi.org/10.1007/s40264-019-00806-5DOI Listing
March 2019
8 Reads

Cutaneous adverse drug reactions in patients with peripheral blood eosinophilia during antituberculosis treatment.

Korean J Intern Med 2019 Mar 19. Epub 2019 Mar 19.

Department of Internal Medicine, Chonnam National University Hospital, Gwangju, Korea.

Background/aims: Peripheral eosinophilia during tuberculosis (TB) treatment is common, but has not been fully evaluated. The aim of this study was to determine the prevalence and clinical significance of peripheral blood eosinophilia in patients undergoing anti-TB treatment.

Methods: We retrospectively reviewed the clinical and laboratory data of patients who received anti-TB treatment and had peripheral blood eosinophilia (> 5% of the total white blood cell count) at the Chonnam National University Hospital between January 2010 and December 2014. Read More

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http://dx.doi.org/10.3904/kjim.2018.063DOI Listing
March 2019
1 Read

Common Annular Lesions in the Pediatric Population: Part 2.

Pediatr Ann 2019 Mar;48(3):e135-e138

Rash is a common chief complaint for patients presenting to their physician, especially within the pediatric field. The ability to distinguish characteristics of a rash, including morphology, distribution, and configuration, is critical to forming the differential diagnosis. This is the second article of a 2-part review that discusses the common rashes that present in an annular configuration. Read More

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http://dx.doi.org/10.3928/19382359-20190222-01DOI Listing
March 2019
3 Reads

Allergic reaction to platelet-rich plasma (PRP): Case report.

Medicine (Baltimore) 2019 Mar;98(10):e14702

Department of Paediatric Orthopaedics, Medical University of Lublin.

Rationale: In the recent years, growing interest is focused on the use of platelet-rich plasma (PRP) in wound healing and tissue regeneration. There are a number of papers regarding the usefulness of PRP in the healing of ulcerations, skin injures, bone loss or distraction osteogenesis. Most authors emphasize the safety of PRP usage due to its authogenic nature. Read More

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http://dx.doi.org/10.1097/MD.0000000000014702DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417490PMC
March 2019
19 Reads

Fixed drug eruption on the tongue associated with piroxicam: report of two cases and literature review.

Oral Surg Oral Med Oral Pathol Oral Radiol 2019 Feb 6. Epub 2019 Feb 6.

Associate Professor, Department of Oral Medicine and Pathology, Faculty of Dentistry, National and Kapodistrian University of Athens, Athens, Greece. Electronic address:

Objective: The aim of this study was to describe 2 patients with piroxicam-associated fixed drug eruption on the tongue and to review the literature.

Study Design: Two females presented with recurrent ulcers after taking piroxicam for dysmenorrhea and pelvic pain. The English language literature was reviewed for cases of piroxicam-induced fixed drug eruptions, with a report on the site of occurrence. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22124403193010
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http://dx.doi.org/10.1016/j.oooo.2019.01.073DOI Listing
February 2019
12 Reads

[Drug rash with eosinophilia and systemic symptoms or DRESS syndrome. Report of one case].

Rev Med Chil 2019 ;147(1):114-118

Servicio de Anatomía Patológica, Hospital Clínico San Borja Arriarán, Santiago, Chile.

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http://dx.doi.org/10.4067/S0034-98872019000100114DOI Listing
March 2019
5 Reads

Drug Reaction with Eosinophilia and Systemic Symptoms Syndrome associated with Ethambutol use: A Case Report.

Curr Drug Saf 2019 Mar 7. Epub 2019 Mar 7.

Department of pharmacology Lady Hardinge Medical College and associated hospitals. India.

Among the first line anti-tubercular drugs (ATDs), ethambutol has been rarely associated to cause drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome. A 34-year-old woman presented in out-patient department of Dermatology with fever, skin eruptions, eosinophilia, hyperinflated lung fields and deranged liver enzymes after 35 days of the initiation of ATDs. The patient recovered completely after stopping ethambutol and administration of topical and systemic corticosteroids. Read More

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http://dx.doi.org/10.2174/1574886314666190307150757DOI Listing
March 2019
2 Reads

Cutaneous reactions to targeted therapies in children with CNS tumors: A cross-sectional study.

Pediatr Blood Cancer 2019 Jun 28;66(6):e27682. Epub 2019 Feb 28.

Dermatology Program, Boston Children's Hospital, Boston, Massachusetts.

Background: MAPK (RAS-RAF-MEK-ERK-MAP) and mTOR inhibitors are novel treatments for pediatric central nervous system (CNS) tumors. The literature on common cutaneous adverse reactions to these therapies is sparse in the pediatric population. The aim of this study was to describe common cutaneous adverse reactions to BRAF, MEK, and mTOR inhibitors in children with CNS tumors. Read More

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http://dx.doi.org/10.1002/pbc.27682DOI Listing
June 2019
1 Read

Paliperidone Injection-Associated Delayed-Onset Rash.

Prim Care Companion CNS Disord 2019 Jan 24;21(1). Epub 2019 Jan 24.

Department of Psychiatry, University of Louisville School of Medicine, Louisville, Kentucky, USA.

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http://dx.doi.org/10.4088/PCC.18l02323DOI Listing
January 2019
1 Read

Escitalopram-Induced Rash.

Prim Care Companion CNS Disord 2019 Jan 31;21(1). Epub 2019 Jan 31.

Department of Psychiatry, Behavioral Health Services, Henry Ford Health System, Detroit, Michigan, USA.

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http://dx.doi.org/10.4088/PCC.18l02302DOI Listing
January 2019

Erythema Nodosum Masking Kawasaki Disease with an Initial Manifestation of Skin Lesions.

Yonsei Med J 2019 Mar;60(3):312-314

Department of Pediatrics, Saiseikai Shimonoseki General Hospital, Shimonoseki, Japan.

We report the first case demonstrating an association between Kawasaki disease (KD) and erythema nodosum (EN). A 3-year-old girl presented with EN as an initial manifestation of KD. At the initial visit, she showed high fever of 40°C, injection of the oropharynx, cervical lymphadenopathy, and red-purple cutaneous nodules, particularly on the lower limbs. Read More

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http://dx.doi.org/10.3349/ymj.2019.60.3.312DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391528PMC
March 2019
1 Read

Comparative Study of Frozen and Paraffin-Embedded Sections: Evaluation of Inflammatory Dermatoses.

Isr Med Assoc J 2019 Feb;21(2):82-84

Department of Dermatology, Sourasky Tel Aviv Medical Center, Tel Aviv, Israel.

Background: Frozen section (FS) is often performed when histopathological evaluations are urgently required for implementation of therapeutic measures. In dermatology, this method is most commonly used to evaluate excision margins of tumors. FS are also routinely employed to differentiate toxic epidermal necrolysis from staphylococcal scalded skin syndrome. Read More

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February 2019
9 Reads

Nested case-control study investigating the diagnostic role of tissue eosinophilia in adverse cutaneous drug reactions.

J Eur Acad Dermatol Venereol 2019 Feb 15. Epub 2019 Feb 15.

Department of Dermatology, Tel Aviv Sourasky Medical Center, Affiliated with Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Background: Although tissue eosinophilia has traditionally been considered diagnostically supportive of adverse cutaneous drug reactions (ACDRs), studies have suggested it is neither a sensitive nor a specific finding in drug eruptions (DEs).

Objectives: Determining whether skin tissue eosinophilia is a reliable indicator of ACDR.

Methods: A nested case-control retrospective study conducted in a cohort of 170 patients at a single institution. Read More

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http://dx.doi.org/10.1111/jdv.15509DOI Listing
February 2019
1 Read

Bullous Pemphigoid-like Skin Eruption during Treatment with Rivaroxaban: A Clinical Case Study.

Eur J Case Rep Intern Med 2018 21;5(3):000724. Epub 2018 Mar 21.

Serviço de Anatomia Patológica, Centro Hospitalar Vila Nova de Gaia/Espinho, Portugal.

Little has been documented about hypersensitivity reactions caused by treatment with rivaroxaban. This paper reports a bullous pemphigoid-like skin eruption that occurred in a 76-year-old female patient during rivaroxaban treatment. This case highlights the vigilance required by healthcare workers in recognising potential adverse effects of newly marketed drugs and in making medication changes when necessary. Read More

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https://www.ejcrim.com/index.php/EJCRIM/article/view/724
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http://dx.doi.org/10.12890/2018_000724DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346955PMC
March 2018
3 Reads

Glutathione S-transferase polymorphisms in patients with photosensitive and non-photosensitive drug eruptions.

Photodermatol Photoimmunol Photomed 2019 Feb 8. Epub 2019 Feb 8.

Department of Dermatology, Tel Aviv Sourasky Medical Center, affiliated with Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Background: Glutathione S-transferases (GSTs) play a critical role in cellular protection against oxidative damage. Polymorphisms in three major GST loci have been described. A number of studies have looked for an association between GSTs and skin diseases. Read More

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http://doi.wiley.com/10.1111/phpp.12454
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http://dx.doi.org/10.1111/phpp.12454DOI Listing
February 2019
15 Reads

Bronchiolitis Obliterans After Cefuroxime-Induced Stevens-Johnson Syndrome.

Am J Case Rep 2019 Feb 9;20:171-174. Epub 2019 Feb 9.

Department of Inernal Medicine, King Saud Bin Abdulaziz University for Health Sciences, King Abdulaziz Medical City, Jeddah, Saudi Arabia.

BACKGROUND Bronchiolitis obliterans is the term used to describe a clinical syndrome of irreversible airflow obstruction. Among the etiologies linked to this entity is the rarely reported association with Stevens-Johnson syndrome, which has had a poor outcome in most of the previously published cases. The optimum management of bronchiolitis obliterans as a complication of Stevens-Johnson syndrome is not well defined. Read More

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http://dx.doi.org/10.12659/AJCR.913723DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380208PMC
February 2019
1 Read

Efficacy and toxicity of apatinib combined with or without chemotherapy for patients with advanced or metastatic chemotherapy-refractory gastric adenocarcinoma: A prospective clinical study.

Medicine (Baltimore) 2019 Feb;98(6):e13908

Department of Chemotherapy, Jiangsu Cancer Hospital & Jiangsu Institute of Cancer Research &The Affiliated Cancer Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, China.

Apatinib (Jiangsu HengRui Medicine Co. Ltd), a vascular endothelial growth factor receptor 2 (VEGFR-2) tyrosine kinase inhibitor, has been proven to be safe and to significantly prolong survival in advanced chemotherapy-refractory gastric cancer. This study aimed to assess and compare the efficacy and safety of apatinib combined with chemotherapy with that of chemotherapy alone as second- or higher-line treatment in patients with advanced and metastatic gastric or those with metastatic gastroesophageal junction adenocarcinoma (mGC). Read More

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http://dx.doi.org/10.1097/MD.0000000000013908DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380695PMC
February 2019
1 Read

Epidermal necrolysis: SCORTEN performance in AIDS and non-AIDS patients.

An Bras Dermatol 2019 Jan-Feb;94(1):17-23

Division of Dermatology, Department of Internal Medicine, Universidade Estadual de Ponta Grossa, Ponta Grossa (PR), Brazil.

Background: Stevens-Johnson syndrome and toxic epidermal necrolysis are life-threatening blistering drug reactions with high incidence of ocular sequela. The term 'Epidermal Necrolysis' has been recently used to better describe the full spectrum of the disease that includes Stevens-Johnson syndrome and toxic epidermal necrolysis at opposite ends, which differ by the extent of body surface area with epidermal detachment. SCORTEN is a mortality prognosis score for 'Epidermal Necrolysis' cases that still needed validation in acquired immunodeficiency syndrome. Read More

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http://dx.doi.org/10.1590/abd1806-4841.20196864DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360969PMC
February 2019
2 Reads

Unmet needs of cancer patients with chemotherapy-related hand-foot syndrome and targeted therapy-related hand-foot skin reaction: A qualitative study.

Eur J Oncol Nurs 2019 Feb 6;38:65-69. Epub 2018 Dec 6.

Keio Cancer Center, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan. Electronic address:

Purpose: The objective of this qualitative study was to understand the perceived needs of advanced-stage cancer patients with chemotherapy-related hand-foot syndrome (HFS) and/or targeted therapy-related hand-foot skin reaction (HFSR).

Method: Face-to-face interviews were conducted with 20 outpatients with advanced/recurrent cancer and chemotherapy-related HFS and/or targeted therapy-related HFSR using a semi-structured interview guide at Keio University Hospital, Tokyo, Japan. Thematic analysis was used to analyse the data. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S14623889183015
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http://dx.doi.org/10.1016/j.ejon.2018.12.001DOI Listing
February 2019
10 Reads

Case 2: A 13-year-old Boy with a Perplexing Rash.

Pediatr Rev 2019 Feb;40(2):82-84

Wright Patterson AFB/Department of Pediatrics, Wright State University/Boonshoft School of Medicine, Dayton, OH.

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http://pedsinreview.aappublications.org/lookup/doi/10.1542/p
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http://dx.doi.org/10.1542/pir.2018-0128DOI Listing
February 2019
2 Reads

Drug rash with eosinophilia and systemic symptoms (DRESS) syndrome induced by imatinib.

Curr Drug Saf 2019 Jan 30. Epub 2019 Jan 30.

National Center Chalbi Belkahia of Pharmacovigilance, 9 Avenue du Dr Zouhaier Essafi 1006, Tunis.. Tunisia.

Imatinib is the treatment of choice in patients with locally advanced or metastatic gastrointestinal stromal tumours (GIST). Clinical tolerance of imatinib is excellent except the common adverse drug reaction (ADR). Drug rash with eosinophilia and systemic symptoms (DRESS syndrome) is a severe, potentially life-threatening drug-induced hypersensitivity reaction, characterized by cutaneous eruptions, fever, diffuse lymphadenopathy, along with eosinophilia, and elevated liver function tests. Read More

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http://www.eurekaselect.com/169478/article
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http://dx.doi.org/10.2174/1574886314666190130150243DOI Listing
January 2019
11 Reads

Thrombopoietin Receptor Agonists in the Treatment of Chronic Resistant Primary Immune Thrombocytopenia: Efficacy and Safety Data in Real Clinical Practice.

Ter Arkh 2018 Aug;90(7):70-76

National Medical Research Center of Children's Hematology, Oncology and Immunology named after Dmitry Rogachev of the Russian Federation Ministry of Health, Moscow, Russia.

Aim: To analyze the long-term efficacy and safety of ATR in adult patients with primary resistant ITP in real-world clinical practice.

Materials And Methods: The article contains long-term results analysis of ATR application under real clinical practice conditions in 138 patients (40 men and 98 women) whose median age at the beginning of therapy was 59 (18-86) years. Two ATR medicines-romiplostim (100 patients) and eltrombopag (38 patients) were used. Read More

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http://dx.doi.org/10.26442/terarkh201890770-76DOI Listing
August 2018
3 Reads

[Treatment of mucocutaneous toxicity of target therapy in oncology].

Rev Med Liege 2019 Jan;74(1):7-14

Service de Dermatologie, CHU Sart Tilman, Liège, Belgique.

The spectrum of the mucocutaneous adverse effects of directed oncologic therapies, such as anti-EGFR, anti-VEGF, anti-TK and anti-BRAF, presents similarities but also differences compared to that of the classic chemotherapeutics. This article reviews the dermatological toxicities of the targeted therapies, with 11 clinical cases, including mucositis and oral toxicities, the acne-like eruptions, nail changes and complications, the «hand/foot» syndrome, radiosensitization, alopecias, xerosis and skin fissures. After a brief clinical case presentation and theoretical issues, the clinical management is discussed in detail. Read More

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January 2019
1 Read

Orange-red plaques in an older patient.

BMJ 2019 Jan 24;364:l2. Epub 2019 Jan 24.

Department of dermatology, Kingston Hospital, London, UK.

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http://dx.doi.org/10.1136/bmj.l2DOI Listing
January 2019
1 Read

Case Report: Acute Generalized Exanthematous Pustulosis Caused by Praziquantel.

Am J Trop Med Hyg 2019 Mar;100(3):700-702

Department of General Internal Medicine, Kobe City Medical Center General Hospital, Kobe, Japan.

Praziquantel is widely used for treating parasitic infections globally, especially in countries with endemic schistosomiasis. However, severe hypersensitivity to praziquantel has rarely been reported. We report the case of a 30-year-old Japanese man who developed acute generalized exanthematous pustulosis (AGEP), which is a rare and severe cutaneous reaction usually triggered by drugs, after taking praziquantel. Read More

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http://dx.doi.org/10.4269/ajtmh.18-0832DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402890PMC
March 2019
3 Reads

Dermatomyositis associated with omalizumab therapy for severe asthma: a case report.

Allergy Asthma Clin Immunol 2019 17;15. Epub 2019 Jan 17.

3Department of Medicine, Western University, London, ON Canada.

Background: Omalizumab is a humanized monoclonal antibody widely used for treatment of persistent allergic asthma and antihistamine-refractory chronic urticaria. Immediate adverse events to omalizumab are well characterized. Delayed anaphylactoid and serum sickness-like reactions have also been described; however, their relationship to the drug remains uncertain, and the frequency is unknown. Read More

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http://dx.doi.org/10.1186/s13223-019-0319-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337756PMC
January 2019
2 Reads

Analysis of Individual Case Safety Reports of Severe Cutaneous Adverse Reactions in Korea.

Yonsei Med J 2019 Feb;60(2):208-215

Institute of Allergy and Clinical Immunology, Seoul National University Medical Research Center, Seoul, Korea.

Purpose: Despite morbidities and fatalities, nationwide epidemiologic data for severe cutaneous adverse reactions (SCARs), including Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and drug reaction with eosinophilia and systemic symptoms (DRESS), are not widely available. We aimed to investigate SCAR epidemiology over the last two decades in Korea.

Materials And Methods: We analyzed individual case safety reports (ICSRs) of SCARs in the Korea Adverse Event Reporting System from 1988 to 2013. Read More

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http://dx.doi.org/10.3349/ymj.2019.60.2.208DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6342723PMC
February 2019
4 Reads

Genital Herpes Zoster as Possible Indicator of HIV Infection.

Acta Dermatovenerol Croat 2018 Dec;26(4):337-338

Associate Professor Suzana Ljubojević Hadžavdić, MD, PhD, Department of Dermatology and Venereology, University Hospital Center Zagreb, University of Zagreb School of Medicine, Šalata 4, 10000 Zagreb, Croatia;

Herpes zoster (HZ) is an acute, cutaneous viral infection caused by the reactivation of varicella-zoster virus (VZV) (1). It is a frequent medical condition with an incidence rate of 2-3 cases per 1000 person/years in the general population and 7-10 cases per 1000 person/years after the age of 50 (1,2). Risk factors and triggers for reactivation of HZV have not yet been determined precisely, but are likely to include malignancies, immune deficiencies, solid organ and bone marrow transplant recipients, autoimmune diseases, psychological conditions, emotional stress, human immunodeficiency virus (HIV) infection, and other patients receiving immunosuppressive therapies (1,3). Read More

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December 2018
10 Reads

Severe Cutaneous Adverse Reactions in Korean Pediatric Patients: A Study From the Korea SCAR Registry.

Allergy Asthma Immunol Res 2019 Mar;11(2):241-253

Department of Pediatrics, Seoul National University College of Medicine, Seoul, Korea.

Purpose: Although severe cutaneous adverse drug reactions (SCARs) are rare, they are associated with high morbidity and mortality, and thus early diagnosis and treatment are critical for improving prognoses. However, few studies have reported the characteristics of SCARs in children. Thus, we aimed to evaluate the clinical characteristics, current management and prognosis of pediatric SCARs. Read More

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http://dx.doi.org/10.4168/aair.2019.11.2.241DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340806PMC
March 2019
6 Reads

Lacrimal passage irrigation in children with Stevens-Johnson syndrome or toxic epidermal necrolysis: a five-year retrospective study.

BMC Ophthalmol 2019 Jan 18;19(1):22. Epub 2019 Jan 18.

Department of Ophthalmology, Children's Hospital of Chongqing Medical University, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing, 400014, China.

Background: To identity the effect of lacrimal system irrigation in the acute stage in children with Stevens-Johnson syndrome (SJS) or toxic epidermal necrolysis (TEN).

Methods: A retrospective review of 39 patients with SJS or TEN from 2012 to 2017 was analyzed. Patients were divided into two subgroups according to whether they received irrigation in the acute stage. Read More

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http://dx.doi.org/10.1186/s12886-018-1014-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339389PMC
January 2019
6 Reads

Cutaneous adverse drug reactions: A four-year audit from a district hospital in Johor, Malaysia.

Authors:
H S Kim M M Tang

Med J Malaysia 2018 Dec;73(6):397-399

Hospital Kuala Lumpur, Kuala Lumpur, Malaysia.

Cutaneous adverse drug reactions (cADR) are common. However, only very few audits reported the clinical characteristics of cADR captured at district hospitals. We performed a 4-year audit on cADR reported to the Department of Pharmacy in Hospital Pakar Sultanah Fatimah between May 2012 and March 2016. Read More

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December 2018
2 Reads

Histological Features of Flagellate Erythema.

Am J Dermatopathol 2019 Jan 11. Epub 2019 Jan 11.

Dermatopathology Group, Department of Anatomical Pathology, PathWest Laboratory Medicine, Perth, Western Australia, Australia.

Flagellate erythema is a distinctive eruption characterized by "whip-like" linear or curvilinear streaks and plaques, occurring mainly on the trunk. It has classically been described in 2 disparate clinical settings: chemotherapy with bleomycin and ingestion of mushrooms (most commonly Shiitake mushrooms). Most of the literature comprises single case reports, often with minimal histological description of rather nonspecific features. Read More

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http://dx.doi.org/10.1097/DAD.0000000000001271DOI Listing
January 2019
3 Reads

Rare occurrence of hand-foot syndrome due to paclitaxel: A rare case report.

Indian J Pharmacol 2018 Sep-Oct;50(5):284-286

Department of Medical and Paediatric Oncology, GCRI, Ahmedabad, Gujarat, India.

Hand-foot syndrome (HFS) is a relatively frequent adverse reaction to certain anticancer drugs. HFS is a type of dermatitis which has been most commonly described with 5-fluorouracil and capecitabine. However, HFS with paclitaxel is rare and has been reported sparingly in the literature. Read More

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http://dx.doi.org/10.4103/ijp.IJP_547_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6302696PMC
April 2019
1 Read

Spontaneous Resolution of Cholesteatoma in a Patient on Long-Term Infliximab.

Ann Otol Rhinol Laryngol 2019 Apr 11;128(4):365-368. Epub 2019 Jan 11.

2 MEEI, Boston, MA, USA.

Objective:: To describe an observed case of spontaneous regression of cholesteatoma in a patient on chronic anti-tumor necrosis factor-alpha (TNF-a) therapy and inspire further research into the role of TNF-a in cholesteatoma.

Methods:: Clinical assessment of disease in a single-patient case report.

Results:: A 49-year-old woman suffered a severe case of Stevens-Johnson syndrome when she was 12 years old, leaving her with bilateral corneal opacification and tympanic membrane perforations with extensive cholesteatoma. Read More

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http://dx.doi.org/10.1177/0003489418823790DOI Listing
April 2019
9 Reads

Markers of systemic involvement and death in hospitalized cancer patients with severe cutaneous adverse reactions.

J Am Acad Dermatol 2019 Mar 26;80(3):608-616. Epub 2018 Oct 26.

Dermatology Service, Memorial Sloan Kettering Cancer Center, New York, New York; Department of Dermatology, Weill Cornell Medical College, New York, New York. Electronic address:

Background: Severe cutaneous adverse reactions (SCARs) are frequent in inpatient oncology. Early intervention might reduce morbidity, mortality, and hospitalization costs; however, current clinical and histologic features are unreliable SCAR predictors. There is a need to identify rational markers of SCARs that could lead to effective therapeutic interventions. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01909622183280
Publisher Site
http://dx.doi.org/10.1016/j.jaad.2018.10.039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372330PMC
March 2019
15 Reads

A Probable Case of Mucosal Fixed Drug Eruption Following Treatment with Silodosin.

Authors:
Eleni Klimi

Sultan Qaboos Univ Med J 2018 Aug 19;18(3):e402-e404. Epub 2018 Dec 19.

Department of Dermatology, Thriasio General Hospital, Athens, Greece.

A fixed drug eruption consists of erythematous patches that appear on the skin and/or mucous membranes following administration of a drug which, once healed, leaves residual hyperpigmentation. We report a 76-year-old male who presented to the Thriasio General Hospital, Athens, Greece, in 2016 with erythema, oedema and blistering of the lower lip and penis following the administration of silodosin for benign prostatic hyperplasia. The eruption regressed two weeks after silodosin was discontinued. Read More

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http://dx.doi.org/10.18295/squmj.2018.18.03.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307627PMC
August 2018
1 Read

Development of Pityriasis Amiantacea after Valproic Acid Therapy.

Int J Trichology 2018 Sep-Oct;10(5):237-239

Department of Pathology, Northshore University Health System, University of Chicago, Chicago, IL, USA.

Here, we present the case of a 16-year-old male who developed pityriasis amiantacea (PA) after the use of valproic acid. We propose that the keratinocyte proliferative activity of valproic acid mediated through the inhibition of glycogen synthase kinase-3β, and subsequent activation of the Wnt/β-catenin pathway could play a role in the development of PA. We additionally review the most relevant characteristics of this disease. Read More

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http://dx.doi.org/10.4103/ijt.ijt_53_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6290282PMC
January 2019
2 Reads

Oxcarbazepine-Induced Stevens-Johnson Syndrome.

Prim Care Companion CNS Disord 2018 Dec 20;20(6). Epub 2018 Dec 20.

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http://dx.doi.org/10.4088/PCC.18l02304DOI Listing
December 2018
4 Reads

The effects of prednisolone treatment on serological responses and lipid profiles in Ethiopian leprosy patients with Erythema Nodosum Leprosum reactions.

PLoS Negl Trop Dis 2018 12 28;12(12):e0007035. Epub 2018 Dec 28.

London School of Hygiene and Tropical Medicine (LSHTM), London, United Kingdom.

Background: Erythema nodosum leprosum (ENL) is a systemic inflammatory complication occurring mainly in patients with lepromatous leprosy (LL) and borderline lepromatous leprosy (BL). Prednisolone is widely used for treatment of ENL reactions. However, it has been reported that prolonged treatment with prednisolone increases the risk for prednisolone-induced complications such as osteoporosis, diabetes, cataract and arteriosclerosis. Read More

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http://dx.doi.org/10.1371/journal.pntd.0007035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6328235PMC
December 2018
4 Reads

β-Hydroxy-β-methyl Butyrate/L-Arginine/L-Glutamine Supplementation for Preventing Hand-Foot Skin Reaction in Sorafenib for Advanced Hepatocellular Carcinoma.

In Vivo 2019 Jan-Feb;33(1):155-161

Department of Gastroenterology, Kusunoki Hospital, Fujioka, Japan.

Background/aim: Sorafenib is standard treatment for advanced hepatocellular carcinoma (HCC). Hand-foot skin reaction (HFSR) is a notorious side-effect of this therapy. This study evaluated prophylactic benefits of an oral nutritional supplement (ONS) on sorafenib-associated HFSR in advanced HCC. Read More

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http://iv.iiarjournals.org/lookup/doi/10.21873/invivo.11452
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http://dx.doi.org/10.21873/invivo.11452DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364076PMC
April 2019
8 Reads

Successful Treatment of Pemphigus Vulgaris With Ofatumumab

J Drugs Dermatol 2018 12;17(12):1338-1339

Rituximab is a chimeric anti-CD20 monoclonal antibody that is very effective in treating patients with pemphigus vulgaris. Though infrequent, the development of human anti-chimeric antibodies in patients receiving rituximab results in loss of efficacy. Ofatumumab is a second-generation fully-human anti-CD20 monoclonal antibody currently used to treat chronic lymphocytic leukemia. Read More

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December 2018
6 Reads