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    22836 results match your criteria Drug Eruptions

    1 OF 457

    Common Skin Conditions in Children: Noninfectious Rashes.
    FP Essent 2017 Feb;453:18-25
    University of North Carolina Chapel Hill School of Medicine Dermatology Residency Program, 410 Market St. Suite 400 CB#7715, Chapel Hill, NC 27516.
    Cutaneous adverse drug reactions are among the most common noninfectious rashes of childhood. Cutaneous adverse drug reactions are classified as morbilliform, urticarial, bullous, pustular, or psoriasiform. Atopic dermatitis is one of the most common inflammatory cutaneous eruptions, and is characterized by pruritus and flexural distribution. Read More

    Metronidazole and Norfloxacin induced Generalized Fixed Drug Eruptions in an adult male patient - A Case Report.
    Curr Drug Saf 2017 Feb 9. Epub 2017 Feb 9.
    Government Medical College and Sir Takhtsinhji General Hospital,India.
    Introduction: Fluoroquinolones are most widely used for empirical treatment of gastrointestinal disease due to emergence of drug resistant strains to other antimicrobials. They are also indulged in cutaneous adverse drug reactions with varying form of severity.

    Case Presentation: A 43 year old male patient developed fixed drug eruptions after administration of tablet norfloxacin and metronidazole for treatment of colicky abdominal pain with diarrhoea. Read More

    The metabolism of methazolamide in immortalized human keratinocytes, HaCaT cells.
    Drug Metab Lett 2017 Jan 27. Epub 2017 Jan 27.
    Department of Ophthalmology, Osaka Prefectural Medical Center for Respiratory and Allergic Diseases, 3-7-1 Habikino, Habikino-shi Osaka 583-8588, Japan.
    Objective: Drug therapy is occasionally accompanied by an idiosyncratic severe toxicity, which occurs very rarely, but can lead to patient mortality. Methazolamide, an anti-glaucomatous agent, could cause severe skin eruptions called Stevens-Johnson syndrome/toxic epidermal necrolyis (SJS/TEN). Its precise etiology is still uncertain. Read More

    Lichenoid Dermatologic Toxicity From Immune Checkpoint Blockade Therapy: A Detailed Examination of the Clinicopathologic Features.
    Am J Dermatopathol 2017 Feb;39(2):121-129
    *Department of Pathology, Section of Dermatopathology, The University of Texas MD Anderson Cancer Center, Houston, TX; Departments of †Dermatology, and ‡Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX.
    Immunotherapy targeting the programmed cell death 1 (PD-1) receptor has demonstrated tremendous promise in the treatment of advanced solid tumors. Dermatologic toxicities, however, are an emerging consequence of this therapy and have been clearly associated with immune checkpoint blockade antibodies. Distinctive clinical and histologic subtypes of dermatologic toxicity secondary to immunotherapy are emerging and include rare autoimmune bullous reactions (eg, bullous pemphigoid) and lichenoid eruptions. Read More

    Cutaneous Reactions to Targeted Therapy.
    Am J Dermatopathol 2017 Feb;39(2):67-82
    *Dermatology Resident, University of Pittsburg Medical Center, Pittsburg, PA; Associate Professor, Departments of †Pathology, and ‡Dermatology, Massachusetts General Hospital, Boston, MA; and §Associate Professor, Harvard Medical School, Boston, MA.
    Over the past decade, numerous targeted therapeutic agents have become available for clinical use in the oncologic setting with the hopes of realizing personalized cancer treatment. These agents have achieved great improvements in clinical outcomes for patients suffering from solid and hematologic malignancies. However, adverse cutaneous reactions are among the most common toxicities observed in patients undergoing treatment with a targeted agent and can alter the overall clinical management strategy. Read More

    Anticonvulsant hypersensitivity syndrome secondary to carbamazepine.
    Proc (Bayl Univ Med Cent) 2017 Jan;30(1):94-96
    Department of Internal Medicine, Baylor Scott & White Hospital, Temple, Texas.
    Anticonvulsant hypersensitivity syndrome (AHS) is a potentially fatal multiorgan drug reaction that presents with various cutaneous eruptions. There is a genetic predisposition to such reactions. We present a young woman with AHS due to carbamazepine that presented as an atypical erythema multiforme with elevated liver enzymes. Read More

    Disseminated eruptive granuloma annulare induced by levetiracetam.
    Cutan Ocul Toxicol 2017 Jan 17:1-2. Epub 2017 Jan 17.
    c Neurology, Abant Izzet Baysal Universitesi , Bolu , Turkey.
    Granuloma annulare (GA) is a benign, granulomatous cutaneous disease without clear etiology. Disseminated and drug induced granuloma annulare is a rare presentation. We present a 47-year-old woman with diffuse circular erythematous eruptions following treatment with levetiracetam. Read More

    Disorders characterized by predominant or exclusive dermal inflammation.
    Semin Diagn Pathol 2016 Dec 14. Epub 2016 Dec 14.
    Section of Dermatopathology, Division of Surgical Pathology & Cytopathology, University of Virginia Medical Center, Room 3020 University of Virginia Hospital, 1215 Lee Street, Charlottesville, VA 22908-0214, USA. Electronic address:
    Some cutaneous inflammatory disorders are typified by a predominant or exclusive localization in the dermis. They can be further subdivided by the principal cell types into lymphocytic, neutrophilic, and eosinophilic infiltrates, and mixtures of them are also seen in a proportion of cases. This review considers such conditions. Read More

    Acute generalized exanthematous pustulosis: clinical characteristics, etiologic associations, treatments, and outcomes in a series of 28 patients at Mayo Clinic, 1996-2013.
    Int J Dermatol 2017 Jan 13. Epub 2017 Jan 13.
    Department of Dermatology, Mayo Clinic, Rochester, MN, USA.
    Background: Acute generalized exanthematous pustulosis (AGEP) is a rare skin condition typically caused by medications. The objective of this study was to examine the clinical features, causes, and outcomes of AGEP at a sole tertiary care center.

    Methods: A retrospective review of patients with AGEP (European Study of Severe Cutaneous Adverse Reactions score of ≥ 5) seen at Mayo Clinic (Rochester, MN, USA) between January 1, 1996, and December 31, 2013, was conducted. Read More

    Anesthetic Management of a Patient with DRESS Syndrome for Renal Transplantation.
    Int J Organ Transplant Med 2016 1;7(4):234-236. Epub 2016 Nov 1.
    Department of Anesthesiology and Critical Care, Institute of Kidney Diseases and Research Centre and Institute of Transplantation Sciences, Ahmedabad, Gujarat, India.
    Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a rare but potentially life-threatening hypersensitivity reaction characterized by widespread erythematous skin eruptions with fever, lymphadenopathy and visceral involvement-hepatitis, nephritis, pericarditis, and pneumonitis. There are numerous reports describing the management of such patients in intensive care units but hardly any describing the intraoperative anesthetic management of such patients. Herein, we report on a patient with DRESS syndrome who was scheduled for renal transplantation. Read More

    Histologic Assessment of Lichenoid Dermatitis Observed in Patients With Advanced Malignancies on Antiprogramed Cell Death-1 (anti-PD-1) Therapy With or Without Ipilimumab.
    Am J Dermatopathol 2017 Jan;39(1):23-27
    *Tissue Pathology and Diagnostic Oncology, Westmead Hospital, Sydney, Australia; †Department of Dermatology, Westmead Hospital, Sydney, Australia; and ‡Sydney Medical School, University of Sydney, Sydney, Australia.
    Lichenoid drug reaction is a common adverse reaction in patients taking immune-modulatory agents such as antiprogramed cell death (PD-1) and cytotoxic T lymphocyte antigen-4 agents. The authors describe the clinical and histologic features of lichenoid drug reaction in 20 biopsies from 15 patients on anti-PD-1 agents and 9 biopsies from 7 patients on anti-PD-1 plus ipilimumab therapy. Clinically, all except 2 patients presented with discrete, violaceous exanthematous papules to plaques. Read More

    Clinical Outcomes and Complications Associated with Fractional Lasers: A Review of 730 Patients.
    Aesthetic Plast Surg 2017 Feb 28;41(1):171-178. Epub 2016 Dec 28.
    FACES+ Plastic Surgery, Dermatology, Skin and Laser Center, La Jolla, CA, USA.
    Background: Fractional lasers were introduced to provide increased safety, while maintaining high efficacy and patient satisfaction. Patients with virtually all Fitzpatrick skin types could be safely treated using a wide spectrum of wavelengths and a broad array of skin conditions, and aging could be addressed. Although safety studies have been reported for ablative CO2 and erbium lasers, surprisingly few data are available on adverse events and complications associated with fractional lasers. Read More

    Cutaneous Side Effects and Transepidermal Water Loss To Gefitinib: A Study of 11 Patients.
    Dermatol Ther (Heidelb) 2016 Dec 21. Epub 2016 Dec 21.
    Department of Dermatology and Venereology, Faculty of Medicine, Universitas Padjadjaran-Dr. Hasan Sadikin General Hospital, Bandung, Indonesia.
    Introduction: Cutaneous side effects caused by epidermal growth factor receptor (EGFR) inhibitors occurred in 45-100% of patients which may lead to therapy modification or interruption. This study aimed to evaluate cutaneous side effects and transepidermal water loss (TEWL) values in non-small cell lung carcinoma (NSCLC) patients who received gefitinib EGFR inhibitor.

    Methods: A descriptive observational study with cross-sectional design and a consecutive sampling method was conducted from 1 February to 4 March 2016. Read More

    [Triggers of exanthematous drug eruptions: Stop intake, treat through or desensitization?]
    Hautarzt 2017 Jan;68(1):29-35
    Klinik und Poliklinik für Dermatologie und Allergologie am Biederstein, Technische Universität München, Biedersteiner Str. 29, 80802, München, Deutschland.
    Drug hypersensitivity reactions affect over 7% of the population and are problematic both for patients and doctors. They frequently occur in the form of exanthematous drug eruptions. The clinical manifestation of delayed hypersensitivity reactions is very variable ranging from localized fixed drug eruptions to life-threatening, severe bullous mucocutaneous eruptions or systemic drug hypersensitivity syndromes. Read More

    The role of the ATM/Chk/P53 pathway in mediating DNA damage in hand-foot syndrome induced by PLD.
    Toxicol Lett 2017 Jan 5;265:131-139. Epub 2016 Dec 5.
    Cancer Biology Research Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China. Electronic address:
    Pegylated liposomal doxorubicin (PLD) has been approved to treat patients with various types of cancers because it rarely caused side effects, such as cardiotoxicity, in comparison to doxorubicin, but it frequently results in hand-foot syndrome (HFS). This may affect the quality of life and require a reduction in the PLD dose. The pathophysiology of HFS was not well understood. Read More

    Can baseline ML Flow test results predict leprosy reactions? An investigation in a cohort of patients enrolled in the uniform multidrug therapy clinical trial for leprosy patients in Brazil.
    Infect Dis Poverty 2016 Dec 6;5(1):110. Epub 2016 Dec 6.
    Tropical Pathology and Public Health Institute, Federal University of Goiás, Goiania, Goiás, Brazil.
    Background: The predictive value of the serology to detection of IgM against the Mycobacterium leprae-derived phenolic glycolipid-I/PGL-I to identify leprosy patients who are at higher risk of developing reactions remains controversial. Whether baseline results of the ML Flow test can predict leprosy reactions was investigated among a cohort of patients enrolled in The Clinical Trial for Uniform Multidrug Therapy for Leprosy Patients in Brazil (U-MDT/CT-BR).

    Methods: This was a descriptive study focusing on the main clinical manifestations of leprosy patients enrolled in the U-MDT/CT-BR from March 2007 to February 2012 at two Brazilian leprosy reference centers. Read More

    Metformin-Induced Generalized Fixed Drug Eruption With Cutaneous Hemophagocytosis.
    Am J Dermatopathol 2016 Dec 19. Epub 2016 Dec 19.
    Departments of *Dermatology, and †Pathology, Fundación Jiménez Díaz, Universidad Autónoma, Madrid, Spain.
    Fixed drug eruption (FDE) consists of recurrent dusky-red to brownish macules or patches at the same sites after the readministration of the causative drug. It usually presents as a solitary lesion, but generalized eruptions have been described. The most frequently implied drugs are antibiotics, anticonvulsants, and analgesics. Read More

    Optimizing combination dabrafenib and trametinib therapy in BRAF mutation-positive advanced melanoma patients: Guidelines from Australian melanoma medical oncologists.
    Asia Pac J Clin Oncol 2016 Dec;12 Suppl 7:5-12
    Olivia Newton John Cancer Wellness & Research Centre, Austin Health Melbourne, Victoria, Australia.
    BRAF mutations occur commonly in metastatic melanomas and inhibition of mutant BRAF and the downstream kinase MEK results in rapid tumor regression and prolonged survival in patients. Combined therapy with BRAF and MEK inhibition improves response rate, progression free survival and overall survival compared with single agent BRAF inhibition, and reduces the skin toxicity that is seen with BRAF inhibitor monotherapy. However, this combination is associated with an increase in other toxicities, particularly drug-related pyrexia, which affects approximately 50% of patients treated with dabrafenib and trametinib (CombiDT). Read More

    [A fixed drug eruption caused by paracetamol].
    Ned Tijdschr Geneeskd 2016 ;160(0):D470
    Huisartsenpraktijk Nederweert, Nederweert.
    Background: Fixed drug eruption is a hypersensitive skin response to drugs, which can present itself in different ways. The skin lesions are usually solitary, but can also appear as a maculopapular rash, Stevens-Johnson syndrome or toxic epidermal necrolysis. While fixed drug eruptions can be caused by various drugs, paracetamol is responsible in 1. Read More

    Linear Folliculotropic CD30-Positive Lymphomatoid Drug Reaction.
    Am J Dermatopathol 2016 Nov 22. Epub 2016 Nov 22.
    *Department of Dermatology, Mackay Memorial Hospital, Taipei, Taiwan; and †Department of Medicine, Mackay Medical College, New Taipei City, Taiwan.
    We report a unique case of probable drug-induced CD30-positive lymphomatoid reaction. A 58-year-old woman presented with bilateral facial eruptions of 3 weeks duration composed of erythematosus papules in a linear distribution. The pathological features demonstrated a dense dermal and follicular infiltrate of many medium- to large-sized atypical CD30-positive lymphoid cells. Read More

    Cutaneous Manifestation of Drug Allergy and Hypersensitivity.
    Immunol Allergy Clin North Am 2017 Feb;37(1):165-181
    Department of Immunology, Rheumatology and Allergy, Medical University of Lodz, 251 Pomorska Street, Lodz 92-213, Poland. Electronic address:
    Drug hypersensitivity reactions may manifest with either organ-specific or systemic symptoms, but cutaneous eruptions are the most common manifestations. Different medications may cause identical skin symptoms, whereas hypersensitivity to a single drug may manifest with various patterns of symptoms depending on the pathomechanism of hypersensitivity. Drug reactions should be also taken into account in the differential diagnosis of numerous skin rashes. Read More

    Pityriasis rubra pilaris-like eruption following insulin therapy initiation.
    Dermatol Pract Concept 2016 Oct 31;6(4):19-21. Epub 2016 Oct 31.
    National Center of Pharmacovigilance, Faculty of Medicine, University of Tunis El Manar, Tunisia.
    Pityriasis rubra pilaris (PRP) is a chronic disorder of keratinization of unclear pathogenesis. PRP-like eruptions induced by drugs have rarely been described. A previously healthy 29-year-old man presented with a generalized, rapidly spreading, erythematosquamous dermatosis, that started three days after initiation of subcutaneous insulin therapy for diabetes mellitus type 1. Read More

    Serum sickness-like drug reaction: two cases with a neutrophilic urticarial pattern.
    J Cutan Pathol 2017 Feb 15;44(2):177-182. Epub 2016 Dec 15.
    Department of Dermatology, University of Minnesota, Minneapolis, MN, USA.
    The diagnosis of serum sickness-like reaction (SSLR) is typically based on clinical findings. Histopathologic examination is often deferred, as these eruptions commonly present in young children, and often to primary care providers. A PubMed literature search revealed only five existing cases of SSLR which describe cutaneous histopathologic features. Read More

    Successful Re-administration of Low-dose of Methimazole (MMI) in Graves' Disease Patients Who Experienced Allergic Cutaneous Reactions to MMI at Initial Treatment and Had Received Long-term Propylthiouracil (PTU).
    Intern Med 2016;55(22):3235-3237. Epub 2016 Nov 15.
    Kubota Thyroid Clinic, Japan.
    Objective When patients with Graves' disease show severe allergic cutaneous reactions, physicians often suggest that they undergo radioiodine therapy instead of receiving propylthiouracil (PTU), another antithyroid drug, because anti-neutrophil cytoplasmic antibody (ANCA) -related vasculitis can occur with PTU, especially with long-term use. However, some patients refuse radioiodine therapy and chose PTU. Sometimes PTU treatment may be prolonged. Read More

    Pseudo-Bullous Dermatosis Induced by Topical Anesthetic Agent-Clues to This Localized Toxic Reaction.
    Am J Dermatopathol 2017 Feb;39(2):e19-e22
    *Department of Otolaryngology, Head and Neck Surgery, OhioHealth Doctors Hospital, Columbus, OH; †Division of Dermatology, Baylor University Medical Center, Dallas, TX; ‡Department of Dermatology, Walter Reed National Military Medical Center, Bethesda, MD; and §Ackerman Academy of Dermatopathology, New York, NY.
    Eutectic mixture of 2.5% lidocaine and 2.5% prilocaine (EMLA AstraZeneca, DE) is a widely used topical anesthetic cream for preprocedural cutaneous analgesia. Read More

    [Implementation of a nurse-driven educational program improves management of sorafenib's toxicities in hepatocellular carcinoma].
    Bull Cancer 2016 Nov 3;103(11):941-948. Epub 2016 Nov 3.
    Centre Eugene-Marquis, oncologie médicale, 35042 Rennes, France. Electronic address:
    Background: Sorafenib is the standard treatment for advanced hepatocellular carcinoma (HCC). Due to its peculiar toxicities, improving patient's tolerance may need close follow-up. Nurses can play a crucial role, by driving a patient education program (EP). Read More

    Assessment of demodex presence in acne-like rash associated with cetuximab.
    Cutan Ocul Toxicol 2016 Nov 16:1-4. Epub 2016 Nov 16.
    b Medical Oncology Department, School of Medicine, Karadeniz Technical University , Trabzon , Turkey , and.
    Context: Cetuximab is an epidermal growth factor receptor inhibitor. It is frequently used in the treatment of solid tumors. However, it has a high potential to cause acne-like rash. Read More

    Clinical characteristics of adverse events associated with therapeutic monoclonal antibodies in Korea.
    Pharmacoepidemiol Drug Saf 2016 Nov 30;25(11):1279-1286. Epub 2016 Jun 30.
    Division of Allergy and Immunology, Department of Internal Medicine, Institute of Allergy, Severance Hospital Regional Pharmacovigilance Center, Yonsei University College of Medicine, Seoul, Korea.
    Purpose: The use of monoclonal antibodies (mAbs) is increasing in various clinical fields. Although mAb safety must be demonstrated prior to approval, targeted pharmacovigilance is essential for the recognition and assessment of adverse reactions. The purpose of this study was to identify the major clinical features of adverse reactions to mAbs in Korea. Read More

    Clinical analysis of HIV/AIDS patients with drug eruption in Yunnan, China.
    Sci Rep 2016 Oct 31;6:35938. Epub 2016 Oct 31.
    Center for Translational Medicine, Huaihe Clinical College, Henan University, Kaifeng 475000, P. R. China.
    Drug eruption is the most common clinical presentation in patients with HIV/AIDS. The systemic clinical and risk factors associated with drug eruption remain unknown. A retrospective analysis in HIV/AIDS patients with drug eruption was carried out with demographic data, epidemiological data, clinical characteristics, laboratory data and follow-up data. Read More

    [Acute generalized exanthematous pustulosis induced by piroxicam].
    Rev Alerg Mex 2016 Oct-Dec;63(4):408-412
    Clínica El Rosario Sede Tesoro. Medellín, Antioquia, Colombia.
    Background: Between 62 and 90% of cases of acute generalized exanthematous pustulosis are caused by drugs. Its onset is rapid with generalized pustules, fever, and blood neutrophil count over 7000; pustules resolve spontaneously in less than 15 days. A case associated with piroxicam described. Read More

    Longitudinal analysis of antibody profiles against plakins in severe drug eruptions: emphasis on correlation with tissue damage in drug-induced hypersensitivity syndrome and drug reaction with eosinophilia and systemic symptoms.
    Br J Dermatol 2016 Nov 28;175(5):944-952. Epub 2016 Aug 28.
    Department of Dermatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
    Background: The evidence for severe drug eruption as a trigger for autoimmune disease has recently increased. No information is available on how tissue damage in severe drug eruptions can induce autoimmune responses.

    Objectives: To investigate whether the generation of autoantibodies (autoAbs) against plakin family proteins could be the cause or result of tissue damage in patients with severe drug eruptions and whether the generation of autoAbs could be prevented by systemic corticosteroids during the acute stage. Read More

    HLA-A*02 alleles are associated with tetanus antitoxin-induced exanthematous drug eruptions in Chinese patients.
    Pharmacogenet Genomics 2016 Dec;26(12):538-546
    aInstitutes of Biomedical Sciences bDepartment of Dermatology, Huashan Hospital cChildren's Hospital and Institutes of Biomedical Sciences, Fudan University, Shanghai dDepartment of Pharmacology, School of Medicine, Zhengzhou University, Zhengzhou, China.
    Objective: Tetanus antitoxin (TAT) is an effective antitetanus medicine, but may sometimes cause adverse drug reactions such as rapid-onset anaphylactic shock and late-onset cutaneous adverse drug reactions, including exanthematous drug eruptions (EDE). Human leukocyte antigen (HLA) class I alleles are strongly associated with different types of cutaneous adverse drug reactions. This study aimed to assess whether there is an association between TAT-induced EDE and HLA-A, HLA-B, and HLA-C alleles in the Chinese Han population. Read More

    A Case of Streptobacillus moniliformis Infection with Cutaneous Leukocytoclastic Vasculitis.
    Acta Med Okayama 2016 Oct;70(5):377-381
    Department of Dermatology, Okayama City Hospital, Okayama 700-8557,
    A 71-year-old man presented with a high fever, polyarthralgia, petechiae and palpable purpura accompanied by livedoid change on his legs and feet. Histopathological findings of the purpura revealed perivascular infiltration of neutrophils, mononuclear cells, and nuclear debris, and extravasation of red cells mainly in the upper dermis: all signs consistent with leukocytoclastic vasculitis. Small vessel thrombi, which are characteristic features of septic vasculopathy, were also observed. Read More

    Erythema Nodosum-Like Panniculitis as a False-Positive 18F-FDG PET/CT in Advanced Melanoma Treated With Dabrafenib and Trametinib.
    Clin Nucl Med 2017 Jan;42(1):44-46
    From the Departments of *Nuclear Medicine, and †Oncology, Marqués de Valdecilla University Hospital, Molecular Imaging Group (IDIVAL), University of Cantabria, Santander, Spain.
    We present a 35-year-old woman with left axillary mass. Histopathological analysis revealed metastatic infiltration for BRAF-mutant melanoma. F-FDG PET/CT showed bilateral axillary lymphadenopathy as well as bone and subcutaneous metastases. Read More

    Eruptive Facial Postinflammatory Lentigo: Clinical and Dermatoscopic Features.
    Am J Dermatopathol 2016 Nov;38(11):813-819
    *Department of Dermatology, Clínica Alemana de Santiago, Chile; †Melanoma Unit, Department of Dermatology, Hospital Clinic of Barcelona, Barcelona, Spain; ‡Department of Pathology, Clínica Alemana de Santiago, Chile; §Department of Medicine, Hospital de Carabineros de Chile, Chile; and ¶Department of Dermatology, Universidad del Desarrollo, Chile.
    The face has not been considered a common site of fixed drug eruption, and the authors lack dermatoscopic studies of this condition on the subject. The authors sought to characterize clinical and dermatoscopic features of 8 cases of an eruptive facial postinflammatory lentigo. The authors conducted a retrospective review of 8 cases with similar clinical and dermatoscopic findings seen from 2 medical centers in 2 countries during 2010-2014. Read More

    Ocular manifestations of Stevens-Johnson syndrome and their management.
    Curr Opin Ophthalmol 2016 Nov;27(6):522-529
    Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts, USA.
    Purpose Of Review: Recent advances and outcomes data in the management of Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS/TEN) demonstrate the need for a universal standard of care for patients admitted with the disease.

    Recent Findings: Amniotic membrane transplantation, aggressive topical corticosteroids, and lubrication in the acute stage are necessary to prevent or mitigate long-term ocular sequelae. If chronic ocular disease does occur, several interventions can be employed to prevent progressive vision loss and discomfort. Read More

    Evaluation of the patients diagnosed with Stevens Johnson syndrome and toxic epidermal necrolysis: a single center experience.
    Turk Pediatri Ars 2016 Sep 1;51(3):152-158. Epub 2016 Sep 1.
    Division of Pediatric Allergy, Department of Pediatrics, Uludağ University School of Medicine, Bursa, Turkey.
    Aim: Stevens Johnson syndrome and toxic epidermal necrolysis are severe acute mucocutaneous diseases. In this study, we evaluated the clinical aspects of Steven Johnson syndrome, toxic epidermal necrolysis and Stevens-Johnson syndrome/toxic epidermal necrolysis overlap patients who admitted to our clinics in the last five years.

    Material And Methods: Eleven patients diagnosed as Stevens-Johnson syndrome, toxic epidermal necrolysis and Stevens-Johnson syndrome/toxic epidermal necrolysis overlap in Department of Pediatric Allergy in Uludağ University School of Medicine were included in this study. Read More

    Clinical approach on challenge and desensitization procedures with aspirin in patients with ischemic heart disease and nonsteroidal anti-inflammatory drug hypersensitivity.
    Allergy 2017 Mar 28;72(3):498-506. Epub 2016 Nov 28.
    Cardiology Unit, Azienda Sanitaria Romagna, Rimini Hospital, Rimini, Italy.
    Background: Hypersensitivity to acetylsalicylic acid (ASA) constitutes a serious problem for subjects with coronary artery disease. In such subjects, physicians have to choose the more appropriate procedure between challenge and desensitization. As the literature on this issue is sparse, this study aimed to establish in these subjects clinical criteria for eligibility for an ASA challenge and/or desensitization. Read More

    Efficacy and Safety of a Permethrin-Fipronil Spot-On Solution (Effitix®) in Dogs Naturally Infested by Ticks in Europe.
    Biomed Res Int 2016 15;2016:9498604. Epub 2016 Sep 15.
    Virbac, 13ème rue, LID, 06511 Carros, France.
    Effitix is a new broad spectrum product based on the combination of fipronil 6.1% and permethrin 54.5% in a solution for spot-on application. Read More

    CD30 Positive Lymphomatoid Angiocentric Drug Reactions: Characterization of a Series of 20 Cases.
    Am J Dermatopathol 2016 Sep 19. Epub 2016 Sep 19.
    *Department of Pathology and Laboratory Medicine, New York Presbyterian Hospital-Weill Cornell Medicine, New York, NY; †Department of Dermatology, University of Colorado Anschutz Medical Campus, Aurora, CO; and ‡Department of Dermatology, University of California at Irvine, Orange, CA.
    Introduction: Lymphomatoid drug reactions are atypical T cell cutaneous lymphocytic infiltrates induced by pharmacological therapy. Due to phenotypic abnormalities, clonality, and their close clinical and morphologic resemblance to T cell lymphomas, these eruptions have been categorized as drug-associated reversible granulomatous T cell dyscrasias.

    Design: A total of 20 cases were encountered in which a diagnosis of CD30 lymphomatoid drug reaction was rendered. Read More

    Immediate Adverse Reactions to Gadolinium-Based MR Contrast Media: A Retrospective Analysis on 10,608 Examinations.
    Biomed Res Int 2016 29;2016:3918292. Epub 2016 Aug 29.
    Department of Diagnostic Imaging, Radiant and Metabolic Therapy, Istituto Nazionale Tumori "Fondazione G. Pascale" IRCCS, 80131 Naples, Italy.
    Background and Purpose. Contrast media (CM) for magnetic resonance imaging (MRI) may determine the development of acute adverse reactions. Objective was to retrospectively assess the frequency and severity of adverse reactions associated with gadolinium-based contrast agents (GBCAs) injection in patients who underwent MRI. Read More

    Levofloxacin Induced Toxic Epidermal Necrolysis: Successful Therapy with Omalizumab (Anti-IgE) and Pulse Prednisolone.
    Am J Case Rep 2016 Sep 16;17:666-71. Epub 2016 Sep 16.
    Department of Infectious Diseases, Akdeniz University, Faculty of Medicine, Antalya, Turkey.
    BACKGROUND Toxic epidermal necrolysis (TEN) is characterized by widespread erythematous and bullous lesions on the skin. Nowadays, considerable progress has been made in the understanding of its pathogenesis. Immunologically it is similar to graft-versus-host disease. Read More

    Bronchoscopic Investigation of Atypical Drug-induced Hypersensitivity Syndrome Showing Viral Lung Involvement.
    Intern Med 2016;55(18):2691-6. Epub 2016 Sep 15.
    Department of Respiratory Disease, Southern Tohoku General Hospital, Japan.
    We herein report a case of atypical drug-induced hypersensitivity syndrome (DIHS) involving serological reactivation of cytomegalovirus induced by carbamazepine with pulmonary and skin manifestations. These lesions were not present on admission, but developed on virus reactivation as indicated by the presence of inclusion bodies and multinucleated giant cells in alveolar cells with CD8(+) T lymphocyte infiltration on a transbronchial lung biopsy. Although the precise mechanism of DIHS remains unknown, this case suggests the crucial role of viral reactivation in pulmonary lesions in DIHS. Read More

    Nilontinib induced keratosis pilaris atrophicans.
    Dermatol Online J 2016 Aug 15;22(8). Epub 2016 Aug 15.
    Department of Dermatology, Cleveland Clinic Foundation.
    Keratosis pilaris (KP) is a disorder of follicular keratinization that is characterized by keratin plugs in the hair follicles with surrounding erythema. A 46-year-old man with chronic myelogenous leukemia (CML) was started on nilotinib, a second generation tyrosine kinase inhibitor (TKI). Two months later the patient noticed red bumps on the skin and patchy hair loss on the arms, chest, shoulders, back, and legs. Read More

    Vancomycin-induced linear IgA bullous dermatosis: associations.
    Dermatol Online J 2016 Apr 18;22(4). Epub 2016 Apr 18.
    Coimbra University Hospital, Coimbra.
    Unlabelled: Linear IgA bullous dermatosis (LABD) is a rare autoimmune blistering disease. LABD is considered mostly idiopathic, butsome cases have been reported to be drug-induced, mainly associated with vancomycin (VCM).We present two cases of LABD possibly associated with VCM used for cardiac surgery prophylaxis; in the presented cases, the eruptions occurred only after VCM withdrawal, therefore leaving a question about the relationship between VCM and LABD in these cases. Read More

    [Human herpes virus 6 infection in an inmunocompetent patient with carbamazepine-induced DRESS syndrome].
    Rev Chilena Infectol 2016 Jun;33(3):340-5
    Departamento de Dermatología, Facultad de Medicina, Pontificia Universidad Católica de Chile, Chile,
    DRESS syndrome (drug reaction with eosinophilia and systemic symptoms) is an adverse life-threatening drug reaction characterized by a polymorphous rash associated with fever, lymphadenopathy and multiorgan involvement with eosinophilia. We present the case of an immunocompetent man with DRESS syndrome secondary to carbamazepine, that developed concomitantly meningoencephalitis caused by human herpes virus 6 (HHV-6), and a review of literature. The pathogenic role of HHV-6 in DRESS syndrome remains controversial. Read More

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