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    Three Cases of Autoimmune Progesterone Dermatitis.
    Ann Dermatol 2017 Aug 21;29(4):479-482. Epub 2017 Jun 21.
    Department of Dermatology, Chonnam National University Medical School, Gwangju, Korea.
    Autoimmune progesterone dermatitis is a rare cyclic premenstrual reaction to progesterone produced during the luteal phase of the menstrual cycle. The clinical symptoms of autoimmune progesterone dermatitis overlap with other forms of dermatosis such as erythema multiforme, eczema, fixed drug eruption, urticaria, and angioedema. We experienced 3 cases of autoimmune progesterone dermatitis. Read More

    Prevalence and Clinical Profile of Drug Eruptions among Antiretroviral Therapy-Exposed HIV Infected People in Yaoundé, Cameroon.
    Dermatol Res Pract 2017 28;2017:6216193. Epub 2017 Jun 28.
    Faculty of Medicine and Biomedical Sciences, University of Yaoundé I, Yaoundé, Cameroon.
    Background: Prevalence and incidence of drug eruptions vary around the world and are influenced by some key factors including HIV infection.

    Objective: This study aimed to find the peculiarities of drug eruptions in people living with HIV (PLHIV) and on antiretroviral therapy (ART).

    Methods: This was a retrospective cross-sectional study including ART-taking PLHIV, aged 15+ years, followed up between January 2010 and December 2014 at the day-care unit of the Yaoundé Central Hospital, and who presented with drug eruptions after ART initiation. Read More

    Outpatient dermatology consultation impacts the diagnosis and management of pediatric oncology patients: A retrospective study.
    J Am Acad Dermatol 2017 Jul 17. Epub 2017 Jul 17.
    Dermatology Program, Boston Children's Hospital, Boston, Massachusetts; Department of Dermatology, Harvard Medical School, Boston, Massachusetts. Electronic address:
    Background: The impact of dermatology consultation on the care of children with oncologic conditions is unknown.

    Objective: To review outpatient dermatology visits and the resulting impact on diagnosis and management of pediatric oncology patients.

    Method: Retrospective review of pediatric oncology patients with outpatient dermatology visits at a tertiary care center from 2008 to 2015. Read More

    A leprosy clinical severity scale for erythema nodosum leprosum: An international, multicentre validation study of the ENLIST ENL Severity Scale.
    PLoS Negl Trop Dis 2017 Jul 3;11(7):e0005716. Epub 2017 Jul 3.
    Department of Clinical Research, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom.
    Objectives: We wished to validate our recently devised 16-item ENLIST ENL Severity Scale, a clinical tool for measuring the severity of the serious leprosy associated complication of erythema nodosum leprosum (ENL). We also wished to assess the responsiveness of the ENLIST ENL Severity Scale in detecting clinical change in patients with ENL.

    Methods: Participants, recruited from seven centres in six leprosy endemic countries, were assessed using the ENLIST ENL Severity Scale by two researchers, one of whom categorised the severity of ENL. Read More

    Meta-analysis of randomized and quasi-randomized clinical trials of topical antibiotics after primary closure for the prevention of surgical-site infection.
    Br J Surg 2017 Aug 28;104(9):1123-1130. Epub 2017 Jun 28.
    Discipline of General Practice, School of Medicine, University of Queensland, Brisbane, Queensland, Australia.
    Background: Surgical-site infections (SSIs) increase patient morbidity and costs. The aim was to identify and synthesize all RCTs evaluating the effect of topical antibiotics on SSI in wounds healing by primary intention.

    Methods: The search included Ovid MEDLINE, Ovid Embase, the Cochrane Wounds Specialized Register, Central Register of Controlled Trials and EBSCO CINAHL from inception to May 2016. Read More

    The thymus and activation-regulated chemokine (TARC) level in serum at an early stage of a drug eruption is a prognostic biomarker of severity of systemic inflammation.
    Allergol Int 2017 Jun 22. Epub 2017 Jun 22.
    Department of Dermatology, Shimane University Faculty of Medicine, Izumo, Japan. Electronic address:
    Background: In severe drug eruptions, precise evaluation of disease severity at an early stage is needed to start appropriate treatment. It is not always easy to diagnose these conditions at their early stage. In addition, there are no reported prognostic biomarkers of disease severity in drug eruptions. Read More

    Autoimmune progesterone dermatitis presenting as fixed drug eruption: a case report.
    Dermatol Online J 2017 Jun 15;23(6). Epub 2017 Jun 15.
    Molecular Dermatology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
    Autoimmune progesterone dermatitis (APD) is a rare disorder characterized by periodic skin lesions that erupt during the luteal phase of the menstrual cycle. Clinical manifestations of APD is caused by an unusual allergy to progesterone and has a wide range of clinical manifestations from eczema and urticaria to angioedema and erythema multiforme. A 46-year-old woman described recurrent, round erythematous plaques on the lower lip, both forearms and buttocks. Read More

    Angioimmunoblastic T-Cell Lymphoma Mimicking Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS Syndrome).
    Case Rep Dermatol 2017 Jan-Apr;9(1):74-79. Epub 2017 Mar 21.
    aDepartment of Dermatology, University Hospital Zurich, Zurich, Switzerland.
    Angioimmunoblastic T-cell lymphoma (AITCL) is a rare, aggressive lymphoma which derives from follicular helper T cells, commonly affecting the elderly population. It accounts for 2% of all non-Hodgkin lymphomas, with a reported 5-year overall survival rate of less than 30%. Very often, the clinical picture of AITCL encompasses systemic symptoms such as generalized lymphadenopathy, hepatosplenomegaly, skin rash, anemia, and polyclonal hypergammaglobulinemia. Read More

    Misuse of Topical Corticosteroids over Face: A Clinical Study.
    Indian Dermatol Online J 2017 May-Jun;8(3):186-191
    Department of Dermatology, Swami Dayanand Hospital, New Delhi, India.
    Introduction: Topical corticosteroids (TCS) have been widely used in various dermatological diseases. However, because of inadvertent use, TCS misuse has become a common problem faced by dermatologists in various parts of the world. Prolonged use over the face can cause various side effects such as steroid rosacea, acneiform eruptions, and hypertrichosis. Read More

    Adjuvant Capecitabine for Breast Cancer after Preoperative Chemotherapy.
    N Engl J Med 2017 06;376(22):2147-2159
    From the National Hospital Organization Osaka National Hospital, Osaka (N.M.), Hiroshima City Hiroshima Citizens Hospital, Hiroshima (S. Ohtani), Kyoto Prefectural University of Medicine (I.Y.), and Graduate School of Medicine, Kyoto University (M.T.), Kyoto, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital (K.K.), and Chuo University (Y.O.), Tokyo, Gunma Prefectural Cancer Center, Ota (Y.Y.), National Hospital Organization Kyushu Cancer Center, Fukuoka (S. Ohno), Hyogo Cancer Center, Akashi (S.T.), National Hospital Organization Shikoku Cancer Center, Matsuyama (K.A.), Aichi Cancer Center Hospital, Nagoya (H.I.), and Tohoku University, Sendai (H.S.) - all in Japan; and Yeungnam University Hospital, Daegu (S.-J.L.), Samsung Medical Center, Sungkyunkwan University School of Medicine (Y.-H.I.), Cancer Research Institute, Seoul National University Hospital, Seoul National University College of Medicine (S.-A.I.), Severance Hospital (B.-W.P.) and Gangnam Severance Hospital (J.J.), Yonsei University College of Medicine, Asan Medical Center, University of Ulsan College of Medicine (S.-B.K.), Korea University Guro Hospital (A.K.), and Korea University Anam Hospital (K.-H.P.), Seoul, and National Cancer Center, Goyang-si (E.-S.L.) - all in South Korea.
    Background: Patients who have residual invasive carcinoma after the receipt of neoadjuvant chemotherapy for human epidermal growth factor receptor 2 (HER2)-negative breast cancer have poor prognoses. The benefit of adjuvant chemotherapy in these patients remains unclear.

    Methods: We randomly assigned 910 patients with HER2-negative residual invasive breast cancer after neoadjuvant chemotherapy (containing anthracycline, taxane, or both) to receive standard postsurgical treatment either with capecitabine or without (control). Read More

    Isolated Actinic Lichen Planus of the Lower Lip.
    Case Rep Dermatol 2017 Jan-Apr;9(1):131-134. Epub 2017 Apr 27.
    National University Hospital, Singapore, Singapore.
    Oral lichen planus (LP) is a common manifestation in patients with LP; however, isolated lip LP is rare and may mimic other conditions such as lichenoid drug eruptions, actinic cheilitis, and early carcinoma in situ in the absence of typical skin lesions. Actinic lichen planus (ALP) is a variant of LP occurring on light-exposed areas in patients with dark skin. We report the case of a Chinese female with isolated ALP of the lower lip, mimicking herpes simplex infection at presentation. Read More

    Fuchs Syndrome: Medical Treatment of 1 Case and Literature Review.
    Case Rep Dermatol 2017 Jan-Apr;9(1):114-120. Epub 2017 Apr 18.
    Department of Odontology, University Hospital of Montpellier, Montpellier, France.
    Fuchs syndrome is a particular type of erythema multiforme major; the lesions are only found on the mucosae and specifically affect oral, ocular, and genital mucosae. The cause is not always immediately apparent, which is why this pathology requires a rigorous, detailed clinical examination to eliminate a differential diagnosis. The severity of the symptoms, particularly of oral and ocular symptoms, requires immediate treatment. Read More

    A Dissimilar Biosimilar?: Lichenoid Drug Eruption Induced by an Infliximab Biosimilar.
    Br J Dermatol 2017 May 30. Epub 2017 May 30.
    Dermatology, Icahn School of Medicine at Mount Sinai, New York, United States.
    The advent of therapeutic antibodies, or biologic medications, has transformed our treatment of many inflammatory diseases in dermatology. Recently, the development of biosimilars, biologic drugs that are highly similar in quality, safety, and efficacy to approved biologics, has changed this landscape. Although biosimilars are not identical to their reference product, they are required to have the same mechanism of action, route of administration, dosage form, and strength as the reference product. Read More

    Lichenoid Drug Eruption with Prominent Nail Changes Due to Leflunomide in a 12-Year-Old Child.
    Pediatr Dermatol 2017 Jul 23;34(4):e225-e226. Epub 2017 May 23.
    Division of Dermatology, Department of Pediatrics, School of Medicine, Seattle Children's Hospital, University of Washington, Seattle, Washington.
    We present the case of a 12-year-old-girl who developed lichenoid dermatitis approximately 1 year after starting leflunomide for juvenile idiopathic arthritis. The eruption resolved promptly with discontinuation of the suspected culprit agent, supportive of a lichenoid drug eruption, but she subsequently developed markedly dystrophic nails with lichen planus-like features. A biopsy of her cutaneous findings at the time of initial presentation demonstrated lichenoid dermatitis, and a nail matrix biopsy was deferred given clinical correlation. Read More

    Purpuric Drug Eruptions Caused by Epidermal Growth Factor Receptor Inhibitors for Non-Small Cell Lung Cancer: A Clinicopathologic Study of 32 Cases.
    JAMA Dermatol 2017 May 24. Epub 2017 May 24.
    Department of Dermatology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.
    Importance: Purpuric skin lesions have only rarely been reported in patients receiving epidermal growth factor receptor inhibitors. However, their clinical and histopathologic presentations have varied considerably.

    Objective: To characterize purpuric skin eruptions caused by epidermal growth factor receptor inhibitors. Read More

    HLA-A*24:02 as a common risk factor for antiepileptic drug-induced cutaneous adverse reactions.
    Neurology 2017 Jun 5;88(23):2183-2191. Epub 2017 May 5.
    Author affiliations are provided at the end of the article.
    Objective: To investigate the involvement of human leukocyte antigen (HLA) loci in aromatic antiepileptic drug-induced cutaneous adverse reactions.

    Methods: A case-control study was performed to detect HLA loci involved in aromatic antiepileptic drug-induced Stevens-Johnson syndrome in a southern Han Chinese population. Between January 1, 2006, and December 31, 2015, 91 cases of Stevens-Johnson syndrome induced by aromatic antiepileptic drugs and 322 matched drug-tolerant controls were enrolled from 8 centers. Read More

    Delayed genital blisters following iodixanol administration.
    Clin Toxicol (Phila) 2017 Sep 2;55(8):939-940. Epub 2017 May 2.
    a Department of Pharmacy , Anning Branch Lanzhou General Hospital Lanzhou Command , Lanzhou , Gansu , P.R. China.
    Iodixanol is a non-ionic contrast medium for general vascular use. The most common adverse effects from iodixanol include skin rashes, hives, erythema, itching, and angioedema. To date, there have been no reports of delayed genital blisters of iodixanol. Read More

    The oral VEGF receptor tyrosine kinase inhibitor pazopanib in combination with the MEK inhibitor trametinib in advanced cholangiocarcinoma.
    Br J Cancer 2017 May 25;116(11):1402-1407. Epub 2017 Apr 25.
    Gastrointestinal Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, 1650 Orleans Street, Room 4M10, Baltimore, MD 21287, USA.
    Background: Cholangiocarcinoma is an aggressive malignancy with limited therapeutic options. MEK inhibition and antiangiogenic therapies have individually shown modest activity in advanced cholangiocarcinoma, whereas dual inhibition of these pathways has not been previously evaluated. We evaluated the safety and efficacy of combination therapy with the oral VEGF receptor tyrosine kinase inhibitor pazopanib plus the MEK inhibitor trametinib in patients with advanced cholangiocarcinoma. Read More

    Dapsone-associated fixed drug eruption.
    Expert Rev Clin Pharmacol 2017 Jul 28;10(7):717-725. Epub 2017 Apr 28.
    b Department of Dermatology , University of California, San Diego , La Jolla , CA , USA.
    Introduction: Dapsone is a sulfone drug used to treat infectious conditions and also numerous dermatologic diseases. Fixed drug eruption is a distinctive adverse cutaneous reaction associated with the initial administration and subsequent delivery of a specific agent. Areas covered: The authors preformed a literature search using the following keywords: dapsone, fixed drug eruption, and adverse cutaneous drug reaction. Read More

    [Epicutaneous patch testing in delayed drug hypersensitivity reactions induced by antiepileptic drugs].
    Therapie 2017 Mar 25. Epub 2017 Mar 25.
    Centre régional de pharmacovigilance de Sfax, faculté de médecine de Sfax, avenue Majida-Boulila, 3029 Sfax, Tunisie.
    Introduction: Antiepileptic drugs are widely used and are associated with numerous side effects including skin eruptions. Epicutaneous tests have been used with variable success in skin drug reactions. The purpose of this study was to evaluate the profitability of epicutaneous tests in delayed hypersensitivity reactions induced by antiepileptic drugs. Read More

    Minocycline-Induced Hyperpigmentation in a Patient Treated with Erlotinib for Non-Small Cell Lung Adenocarcinoma.
    Case Rep Oncol 2017 Jan-Apr;10(1):156-160. Epub 2017 Feb 15.
    Walter Reed National Military Medical Center, Bethesda, MD, USA.
    Introduction: While epidermal growth factor receptor (EGFR) inhibitors have improved progression-free survival in patients with non-small cell lung cancer (NSCLC), one of the most common adverse effects is papulopustular skin eruption, which is frequently severe enough to be treated with oral minocycline or doxycycline.

    Case: We present a case of an 87-year-old man who developed a severe papulopustular skin eruption secondary to erlotinib therapy for NSCLC. Control of the eruption with 100 mg of minocycline twice daily for 8 months eventually led to blue-gray skin hyperpigmentation. Read More

    Viral exanthems: An update on laboratory testing of the adult patient.
    J Am Acad Dermatol 2017 Mar 26;76(3):538-550. Epub 2016 Oct 26.
    Division of Dermatology, Department of Internal Medicine, Ohio State University Comprehensive Cancer Center, Columbus, Ohio. Electronic address:
    Although classic viral exanthems of childhood are well described, they are rarely differentiated in adults. Laboratory techniques for viral identification have advanced without substantial literature to suggest how a dermatologist ought to conduct a cost-effective and diagnostic viral panel. Certain clinical features such as petechiae, vesicles, and dusky macular or morbilliform exanthems point strongly toward a viral exanthem. Read More

    Fever in Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in Pediatric Cases: Laboratory Work-up and Antibiotic Therapy.
    Pediatr Infect Dis J 2017 May;36(5):513-515
    From the Department of Dermatology, Dokumentationszentrum schwerer Hautreaktionen (dZh), Medical Center-University of Freiburg, Hauptstrasse 7, 79104 Freiburg, Germany.
    Fever is a symptom that often accompanies skin eruptions, especially in children. It can be a sign of an infectious condition presenting with exanthems or it may precede an exanthematous eruption. Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are severe reactions affecting skin and mucosa with blisters and erosions. Read More

    Imatinib mesylate-induced lichenoid drug eruption.
    Cutis 2017 Mar;99(3):189-192
    Department of Dermatology and Cutaneous Biology, Thomas Jefferson University, Philadelphia, USA.
    Imatinib mesylate (imatinib) is a tyrosine kinase inhibitor initially approved by the US Food and Drug Administration in 2001 for chronic myeloid leukemia (CML). Since then, the number of indicated uses for imatinib has substantially increased. It is increasingly important that dermatologists recognize adverse cutaneous manifestations of imatinib and are aware of their management and outcomes to avoid unnecessarily discontinuing a potentially lifesaving medication. Read More

    Drug Reaction with Eosinophilia and Systemic Symptoms: Retrospective Analysis of 104 Cases over One Decade.
    Chin Med J (Engl) 2017 Apr;130(8):943-949
    Department of Dermatology, Allergy and Clinical Immunology Centre, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China.
    Background: Drug reaction with eosinophilia and systemic symptoms (DRESS) is a severe, life-threatening disorder caused by drugs. In the present study, we tried to explore the types of DRESS-inducing drugs, incubation period, features of skin rashes, accompanying visceral damage, and effectiveness of glucocorticoid therapy so as to inform clinical practice.

    Methods: Patients diagnosed with a drug-induced rash, dermatitis, and DRESS admitted to our hospital from January 2006 to December 2015 were included in the study. Read More

    Lichenoid and interface dermatoses.
    Semin Diagn Pathol 2017 May 22;34(3):237-249. Epub 2017 Mar 22.
    Department of Radiation Oncology, The Ohio State University, Columbus, OH, United States.
    The terms 'lichenoid' and 'interface' dermatitis are often used interchangeably to describe an inflammatory pattern characterized histologically by damage to the basal keratinocytes in the epidermis. The mechanism of cell damage of such cells is now best understood as apoptosis, or programmed cell death. This inflammatory pattern of dermatoses, is also accompanied frequently by a band of lymphocytes and histiocytes in the superficial dermis, that often obscures the dermal-epidermal junction, hence the term 'lichenoid'. Read More

    Treatment of Human Scabies with Oral Ivermectin. Eczematous Eruptions as a New Non-Reported Adverse Event.
    Actas Dermosifiliogr 2017 Apr 3. Epub 2017 Apr 3.
    Department of Dermatology, Hospital Universitario La Princesa, Spain.
    Background: Oral ivermectin is an alternative therapy for human scabies infection due to its ease of administration and good safety profile. However, there is no definitive consensus on the optimal dosing regimen.

    Objective: To describe the treatment of human scabies with different dosages of oral ivermectin and the possible adverse events. Read More

    [Toxic epidermal necrolysis (Lyell syndrome), a lifethreatening emergency of introgenic origin].
    Rev Med Liege 2016 Oct;71(10):435-439
    Service de Dermatologie, CHU de Liège, site du Sart Tilman, Liège, Belgique.
    Cutaneous drug eruptions are frequently encoun¬tered. Their putative diagnosis is based on a set of imputability arguments. The histopathological aspect is often suggestive of the dermatosis nature, and varies according to the type of drug reaction. Read More

    Non-immediate Cutaneous Reactions to Beta-Lactams: Approach to Diagnosis.
    Curr Allergy Asthma Rep 2017 Apr;17(4):23
    Allergy Unit, Presidio Columbus, Via G. Moscati, 31, 00168, Rome, Italy.
    Non-immediate cutaneous reactions (i.e., occurring at least 1 h after the initial drug administration), particularly maculopapular exanthemas and urticarial eruptions, are common during beta-lactam treatments. Read More

    Cutaneous Manifestations of Diabetes Mellitus: A Review.
    Am J Clin Dermatol 2017 Aug;18(4):541-553
    Department of Dermatology, University Hospital Jena, Erfurter Straße 35, 07740, Jena, Germany.
    Diabetes mellitus is a widespread endocrine disease with severe impact on health systems worldwide. Increased serum glucose causes damage to a wide range of cell types, including endothelial cells, neurons, and renal cells, but also keratinocytes and fibroblasts. Skin disorders can be found in about one third of all people with diabetes and frequently occur before the diagnosis, thus playing an important role in the initial recognition of underlying disease. Read More

    Syphilis: Re-emergence of an old foe.
    Microb Cell 2016 Jun 27;3(9):363-370. Epub 2016 Jun 27.
    Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7435.
    Syphilis is caused by infection with Treponema pallidum subsp. pallidum, a not-yet-cultivable spiral-shaped bacterium that is usually transmitted by sexual contact with an infected partner or by an infected pregnant woman to her fetus. There is no vaccine to prevent syphilis. Read More

    Pharmacologic Impact (aka "Breaking Bad") of Medications on Wound Healing and Wound Development: A Literature-based Overview.
    Ostomy Wound Manage 2017 Mar;63(3):18-35
    School of Nursing-Camden, Rutgers University, Camden, NJ.
    Patients with wounds often are provided pharmacologic interventions for their wounds as well as for their acute or chronic illnesses. Drugs can promote wound healing or substantively hinder it; some medications cause wound or skin reactions. A comprehensive review of extant literature was conducted to examine the impact of drug therapy on wound healing and skin health. Read More

    Generalized bullous fixed drug eruption treated with cyclosporine.
    Dermatol Online J 2017 Feb 15;23(2). Epub 2017 Feb 15.
    Department of Dermatology, University of Texas Southwestern Medical Center.
    Fixed drug eruptions (FDE) comprise 10 percent of alladverse cutaneous drug reactions and generalizedbullous fixed drug eruptions (GBFDE) are a raresubset of FDEs. We present a patient with severeGBFDE caused by ibuprofen successfully treated withcyclosporine. Further work is needed to determine ifcyclosporine can be an effective therapy for GBFDE. Read More

    Capecitabine-induced lichenoid drug eruption: a case report.
    Dermatol Online J 2017 Feb 15;23(2). Epub 2017 Feb 15.
    Richard L. Roudebush VA Medical Center, Indianapolis, Indiana.
    Capecitabine is a 5-fluorouracil basedchemotherapeutic drug widely used in the treatmentof solid tumors, especially colorectal and breast. Someof the most common side effects of capecitabine arecutaneous in nature, including hand-foot syndrome(palmar-plantar erythrodysesthesia). Several reports inthe literature link capecitabine use with photosensitivelichenoid eruptions. Read More

    Certolizumab-induced guttate psoriasiform dermatitis.
    Dermatol Online J 2017 Jan 15;23(1). Epub 2017 Jan 15.
    Division of Dermatology, University of Kansas Medical Center, Kansas City.
    Certolizumab is a TNF inhibitor that has showngreat efficacy in chronic inflammatory diseases. Wereport a patient exhibiting a novel adverse effect ofcertolizumab: drug-induced guttate psoriasiformeruption. A review of the mechanism of psoriasiformdrug eruptions is also included. Read More

    Systemic Immunomodulating Therapies for Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis: A Systematic Review and Meta-analysis.
    JAMA Dermatol 2017 Jun;153(6):514-522
    Dokumentationszentrum schwerer Hautreaktionen, Department of Dermatology, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
    Importance: Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS/TEN) are rare but severe adverse reactions with high mortality. There is no evidence-based treatment, but various systemic immunomodulating therapies are used.

    Objectives: To provide an overview on possible immunomodulating treatments for SJS/TEN and estimate their effects on mortality compared with supportive care. Read More

    Galectin-9 as a Predictive Marker for the Onset of Immune-Related Adverse Effects Associated with Anti-CCR4 MoAb Therapy in Patients with Adult T Cell Leukemia.
    Tohoku J Exp Med 2017 03;241(3):201-208
    Division of Emerging Infectious Diseases, Graduate School of Medicine, Tohoku University.
    Adult T-cell leukemia/lymphoma (ATL/ATLL) is one of the most malignant lymphomas with poor prognosis. ATL/ATLL cells express CC chemokine receptor 4, and mogamulizumab (anti-CCR4 monoclonal antibody) exhibits strong cytotoxicity for ATL/ATLL cells. We analyzed plasma samples of 6 patients with ATL/ATLL treated with chemotherapy followed by mogamulizumab therapy (mogatherapy) for changes in the levels of biomarkers in relation to immune-related adverse effects. Read More

    [In vivo confocal microscopic observation of corneal changes in patients with chronic Stevens-Johnson syndrome or toxic epidermal necrolysis].
    Zhonghua Yan Ke Za Zhi 2017 Mar;53(3):177-181
    Department of Ophthalmology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China.
    Objective: To describe corneal alterations visible on in vivo confocal microscopy in patients with debilitating ocular sequelae caused by Stevens-Johnson syndrome (SJS) or toxic epidermal necrolysis (TEN). Methods: Twenty-two eyes of 11 consecutive patients suffering from chronic SJS or TEN were studied using slit lamp and in vivo confocal microscopy in the Ophthalmology Outpatient Department of Peking Union Medical College Hospital from March 2014 to April 2015. Results: Dry eye with meibomian gland dysfunction (19 eyes of 10 patients, 86. Read More

    Prevention of everolimus-related stomatitis in women with hormone receptor-positive, HER2-negative metastatic breast cancer using dexamethasone mouthwash (SWISH): a single-arm, phase 2 trial.
    Lancet Oncol 2017 May 15;18(5):654-662. Epub 2017 Mar 15.
    The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
    Background: Stomatitis is a class effect associated with the inhibition of mTOR and is associated with everolimus therapy for breast cancer. Topical steroids might reduce stomatitis incidence and severity, and the need for dose reductions and interruptions of everolimus. Anecdotal use of topical steroid oral prophylaxis has been reported in patients with breast cancer. Read More

    Lichen planopilaris-like eruption during treatment with tyrosine kinase inhibitor nilotinib.
    An Bras Dermatol 2016 Sep-Oct;91(5 suppl 1):45-47
    Hospital do Servidor Público Estadual de São Paulo (HSPE) - São Paulo (SP), Brazil.
    Tyrosine kinase inhibitors are effective as a target therapy for malignant neoplasms. Imatinib was the first tyrosine kinase inhibitor used. After its introduction, several other drugs have appeared with a similar mechanism of action, but less prone to causing resistance. Read More

    Vancomycin-associated linear IgA disease mimicking toxic epidermal necrolysis.
    An Bras Dermatol 2016 Sep-Oct;91(5 suppl 1):35-38
    Universidade Federal de São Paulo (Unifesp) - São Paulo (SP), Brazil.
    Linear IgA dermatosis is a rare subepidermal autoimmune blistering disease characterized by linear deposition of IgA along the basement membrane zone. In the last three decades, many different drugs have been associated with the drug-induced form of the disease, especially vancomycin. We report a case of vancomycin-induced linear IgA disease mimicking toxic epidermal necrolysis. Read More

    Bromoderma in an infant.
    An Bras Dermatol 2016 Sep-Oct;91(5 suppl 1):17-19
    Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA) - Porto Alegre (RS), Brazil.
    Bromoderma is a cutaneous eruption caused by the absorption of bromide. Clinical manifestations include acneiform and vegetative lesions. We report the case of an infant with bromoderma caused by the use of syrup for abdominal colic containing calcium bromide. Read More

    Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis Standard Reporting and Evaluation Guidelines: Results of a National Institutes of Health Working Group.
    JAMA Dermatol 2017 Jun;153(6):587-592
    Department of Dermatology, University of California, Davis, Sacramento.
    Importance: Toxic epidermal necrolysis (TEN) and Stevens-Johnson Syndrome (SJS) are rare, acute, life-threatening dermatologic disorders involving the skin and mucous membranes. Research into these conditions is hampered by a lack of standardization of case reporting and data collection.

    Objective: To establish a standardized case report form to facilitate comparisons and maintain data quality based on an international panel of SJS/TEN experts who performed a Delphi consensus-building exercise. Read More

    Difficult clinical management of antituberculosis DRESS syndrome complicated by MRSA infection: A case report.
    Medicine (Baltimore) 2017 Mar;96(11):e6346
    Department of Dermatology, Allergy and Clinical Immunology Centre, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
    Rationale: Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a severe drug-induced hypersensitivity reaction characterized by skin rash, fever, blood abnormalities, and multiple organ involvement. The diagnosis of DRESS syndrome is often delayed because of its variable presentation. Prompt withdrawal of the culprit drug is the definitive treatment. Read More

    Adult-onset Still's disease with atypical cutaneous manifestations.
    Medicine (Baltimore) 2017 Mar;96(11):e6318
    aDepartment of Rheumatology bDepartment of Dermatology, Hospital Universitario de Bellvitge-IDIBELL, Barcelona, Spain.
    The diagnosis of adult-onset Still's disease (AOSD) can be very difficult. There are no specific tests available, and diagnosis is usually based on a symptom complex and the well-described typical evanescent rash seen in the majority of patients. However, in recent years, other atypical cutaneous manifestations of AOSD have been reported. Read More

    A Case of Cycloserine-Induced Lichenoid Drug Eruption Supported by the Lymphocyte Transformation Test.
    Allergy Asthma Immunol Res 2017 May;9(3):281-284
    Department of Internal Medicine, Kangwon National University Hospital, Chuncheon, Korea.
    Lichenoid drug eruption (LDE) is a rare form of delayed-type drug eruption. Among anti-tuberculosis (Tb) agents, cycloserine (CS) has been reported as a rare cause of LDE. Positive results on the lymphocyte transformation test (LTT) have not been reported in patients with LDE. Read More

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