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    1 OF 472

    A patient case highlighting the myriad of cutaneous adverse effects of prolonged use of hydroxyurea.
    Dermatol Online J 2017 Nov 15;23(11). Epub 2017 Nov 15.
    Division of Dermatology, University of Kansas Medical Center, Kansas City, Kansas.
    Background: Hydroxyurea is an antimetabolite primarily used to treat myeloproliferative disorders, and chronic treatment is associated with many cutaneous adverse effects ranging in severity from ichthyosis to aggressive nonmelanoma skin cancer.

    Case Presentation: We report a 67-year-oldman with a history of polycythemia vera who was referred for management of progressively worsening dorsal hand lesions. The patient presented withhyperpigmentation, ichthyosis, plantar keratoderma, dermatomyositis-like eruptions, two squamous cell carcinomas, and actinic keratoses. Read More

    Treatments for Severe Cutaneous Adverse Reactions.
    J Immunol Res 2017 27;2017:1503709. Epub 2017 Dec 27.
    Department of Dermatology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.
    Severe cutaneous adverse reaction (SCAR) is life-threatening. It consists of Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN), drug reaction with eosinophilia and systemic symptoms (DRESS), acute generalized exanthematous pustulosis (AGEP), and generalized bullous fixed drug eruptions (GBFDE). In the past years, emerging studies have provided better understandings regarding the pathogenesis of these diseases. Read More

    ISMP Adverse Drug Reactions: Influenza Vaccine-Induced Stevens-Johnson Syndrome; Vilazodone-Induced Nightmares; Dabigatran-Induced Pustular Eruptions; Neurotoxic and Cardiotoxic Symptoms After Cannabis Concentrate Exposure; Rosuvastatin-Induced Skin Eruption.
    Hosp Pharm 2018 Feb 6;53(1):15-17. Epub 2017 Nov 6.
    Department of Pharmacy Practice, School of Pharmacy, Temple University, Philadelphia, PA, USA.
    The purpose of this feature is to heighten awareness of specific adverse drug reactions (ADRs), discuss methods of prevention, and promote reporting of ADRs to the US Food and Drug Administration's (FDA) MedWatch program (800-FDA-1088). If you have reported an interesting, preventable ADR to MedWatch, please consider sharing the account with our readers. Write to Dr. Read More

    A retrospective study of DRESS - drug reaction with eosinophilia and systemic symptoms.
    Psychiatr Pol 2017 Dec 30;51(6):1079-1093. Epub 2017 Dec 30.
    Klinika Dermatologii, Wenerologii i Alergologii Gdańskiego Uniwersytetu Medycznego.
    Objectives: DRESS (drug reaction with eosinophilia and systemic syndrome) is qualified as hypersensitivity after drug reaction. This syndrome may occur due to any medication intake. There are three main groups of symptoms defining DRESS: skin lesions, hematological abnormalities and internal organ involvement. Read More

    Occupational allergic contact dermatitis caused by antibiotics in healthcare workers - relationship with non-immediate drug eruptions.
    Contact Dermatitis 2018 Feb 5. Epub 2018 Feb 5.
    Dermatology Department, Coimbra Hospital and University Centre (CHUC), Praceta Prof. Mota Pinto, 3000-075, Coimbra, Portugal.
    Background: Occupational allergic contact dermatitis (ACD) in healthcare workers (HCWs) is common, but systemic antibiotics are rarely reported as the cause.

    Objectives: Characterize occupational ACD by handling systemic antibiotics.

    Method: A retrospective analysis was performed of ACD caused by systemic antibiotics among HCWs patch tested between 2010 and 2016 with a series of systemic antibiotics. Read More

    Diverse cutaneous adverse eruptions caused by anti-programmed cell death-1 (PD-1) and anti-programmed cell death ligand-1 (PD-L1) immunotherapies: clinical features and management.
    Ther Adv Med Oncol 2018 22;10:1758834017751634. Epub 2018 Jan 22.
    Division of Dermatology 52-121 CHS, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.
    Background: The anti-programmed cell death-1 (PD-1) and anti-programmed cell death ligand-1 (PD-L1) immunotherapies have shown exceptional activity in many cancers. However, these immunotherapies can also result in diverse adverse cutaneous eruptions that need to be better characterized for ongoing management. The objective was to provide clinical and histopathologic descriptions of the variety of cutaneous adverse events seen in patients who received anti-PD-1/PD-L1 treatment and discuss their management. Read More

    Acute myeloid leukemia presenting as erythema nodosum: A case report.
    Medicine (Baltimore) 2017 Nov;96(47):e8666
    Department of Hematology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
    Rationale: Erythema nodosum (EN), a type of septal panniculitis, could be a rare nonspecific cutaneous presentation of acute myeloid leukemia (AML).

    Patient Concerns: A 58-year-old Chinese female was admitted for a 4-week history of painful cutaneous lesions, accompanied by a sternal pain and fever. The lesions once resolved spontaneously but then recurred. Read More

    Lichen planus and lichenoid drug eruption after vaccination.
    Cutis 2017 Dec;100(6):E6-E20
    Harvard School of Public Health, Boston, Massachusetts, USA; and National Skin Centre, Singapore.
    Lichen planus (LP) and lichenoid drug eruptions (LDEs) uncommonly occur after vaccination, especially for hepatitis B and influenza. The key initiating event that leads to the development of postimmunization LP or LDE is not well understood. There have been prior reports of an association between several vaccines and LP. Read More

    Severe adverse cutaneous drug reactions to antiepileptic drugs: 18 years of experience in a tertiary referral dermatology clinic in Turkey.
    J Eur Acad Dermatol Venereol 2018 Jan 22. Epub 2018 Jan 22.
    Department of Dermatology and Venereology, Istanbul Medical Faculty, Istanbul University, Istanbul, Turkey.
    Antiepileptic drugs (AEDs) are the mainstay of treatment for 1% of the human population suffering from epilepsy.They are also increasingly used for several non-epileptic neurological conditions, such as trigeminal neuralgia, neuropathic pain syndromes, migraine and psychiatric disorders.Three percent of patients who receive AEDs experience adverse cutaneous drug reactions (ACDR),which can range across a wide spectrum from mild to moderate eruptions, such as maculopapular rash and, urticaria, to severe and life-threatening conditions, such as drug reactions with eosinophilia and systemic symptoms (DRESS), Stevens-Johnson syndrome (SJS), and toxic epidermal necrolysis (TEN). Read More

    Generalized Fixed Drug Eruption Induced by Fluconazole Without Cross-Reactivity to Itraconazole: Lymphocyte Transformation Test Confirms the Diagnosis.
    Drug Saf Case Rep 2018 Jan 2;5(1). Epub 2018 Jan 2.
    Division of Immunology and Allergic Diseases, Department of Internal Medicine, Istanbul Faculty of Medicine, Istanbul University, Millet Street, Capa, Istanbul, Turkey.
    We present a rare case of generalized fixed drug eruption caused by fluconazole. A 45-year-old female patient was referred to our outpatient clinic because of suspicious drug eruptions that occurred 5 months earlier and resolved within a month. The patient had sequela of hyperpigmentation on her arms, legs, back, and abdomen after oral administration of the fourth dose of 150 mg of fluconazole once daily because of vaginal candidiasis. Read More

    Fenofibrate-Induced Lichenoid Drug Eruption: A Rare Culprit.
    Case Rep Dermatol 2017 Sep-Dec;9(3):236-242. Epub 2017 Nov 14.
    Department of Rheumatology, Presence Saint Joseph Hospital, Chicago, Illinois, USA.
    A lichenoid drug eruption is a rare side effect which can occur following the administration of several different medications. Here we describe a unique case of fenofibrate as the causative agent of a lichenoid drug eruption. This case highlights a rare and clinically significant dermatologic side effect of fenofibrate. Read More

    Inflammatory dermatoses, infections and drug eruptions are the most common skin conditions in hospitalized cancer patients.
    J Am Acad Dermatol 2017 Dec 19. Epub 2017 Dec 19.
    Dermatology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, 16 E 60th St, New York, NY 10022; Department of Dermatology, Weill Cornell Medical College, 1305 York Ave, New York, NY 10065. Electronic address:
    Background: Dermatologic conditions cause morbidity and mortality among hospitalized cancer patients. An improved understanding is critical for implementing clinical and research programs in inpatient oncodermatology.

    Objective: To characterize inpatient dermatology consultations at a large comprehensive cancer center. Read More

    Deferasirox-induced urticarial vasculitis in a patient with myelodysplastic syndrome.
    An Bras Dermatol 2017 ;92(5 Suppl 1):59-61
    Department of Pathology, Mugla Sitki Kocman University, Faculty of Medicine - Mugla, Turkey.
    Deferasirox is an iron chelator agent used in the treatment of diseases with iron overload, such as thalassemia and myelodysplastic syndrome. Although the majority of adverse reactions of deferasirox involve gastrointestinal symptoms and increase in serum creatinine and transaminases, skin rashes, such as maculopapular and urticarial eruptions, have also been reported. This study reports a case of myelodysplastic syndrome with urticarial vasculitis due to deferasirox therapy. Read More

    Long-term mucocutaneous adverse effects of imatinib in Indian chronic myeloid leukemia patients.
    Int J Dermatol 2018 Mar 20;57(3):332-338. Epub 2017 Dec 20.
    Department of Hematology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
    Background: Short-term mucocutaneous adverse effects are well documented with imatinib. However, studies on long-term adverse effects and in the ethnic population are lacking.

    Objective: To study the long-term mucocutaneous adverse effects of imatinib and factors predicting these adverse effects. Read More

    Cutaneous Adverse Drug Reactions in a Tertiary Care Teaching Hospital in India: An Intensive Monitoring Study.
    Indian J Dermatol 2017 Nov-Dec;62(6):618-625
    Department of Skin and VD, GMERS Medical College, Gotri, Vadodara, Gujarat, India.
    Background: The epidemiological data based on intensive monitoring studies are limited for the cutaneous adverse drug reactions (CADRs) in terms of incidence. Most of earlier Indian studies focused only on types and causative drugs of CADRs.

    Aim: The aim of this study is to analyze the CADRs with reference to the incidence, its subgroup analysis, causative drugs, and other clinical characteristics in Indian population. Read More

    Hand-Foot Syndrome and Post-Progression Treatment Are the Good Predictors of Better Survival in Advanced Hepatocellular Carcinoma Treated with Sorafenib: A Multicenter Study.
    Oncology 2017 20;93 Suppl 1:113-119. Epub 2017 Dec 20.
    Department of Gastroenterology and Hepatology, Takamatsu Red Cross Hospital, Takamatsu, Japan.
    Objective: To determine the relationship between treatment outcomes and hand-foot syndrome (HFS), and the relationship between survival rate and post-progression treatment after sorafenib therapy.

    Methods: The study assessed 314 patients with advanced hepatocellular carcinoma (HCC) treated with sorafenib at 5 general hospitals in Kagawa Prefecture, Japan.

    Results: At the start of sorafenib therapy, 23. Read More

    Increased activated memory B-cells in the peripheral blood of patients with erythema nodosum leprosum reactions.
    PLoS Negl Trop Dis 2017 12 18;11(12):e0006121. Epub 2017 Dec 18.
    London School of Hygiene and Tropical Medicine (LSHTM), Faculty of Infectious Tropical Diseases, London, United Kingdom.
    B-cells, in addition to antibody secretion, have emerged increasingly as effector and immunoregulatory cells in several chronic inflammatory diseases. Although Erythema Nodosum Leprosum (ENL) is an inflammatory complication of leprosy, the role of B- cell subsets has never been studied in this patient group. Therefore, it would be interesting to examine the contribution of B-cells in the pathogenesis of ENL. Read More

    Bevacizumab-associated Sudden Onset of Multiple Monomorphic Comedones on the Scalp Successfully Treated with 30% Salicylic Acid Peels.
    Acta Dermatovenerol Croat 2017 Oct;25(3):245-247
    Eftychia Platsidaki, MD, 5 Ionos Dragoumi Str, 16121 Athens, Greece;
    Bevacizumab is a humanized monoclonal antibody against vascular endothelial factor (VEGF) that targets tumor cell angiogenesis and proliferation. Although it is usually well tolerated, many side-effects have been reported. These include hypertension, bleeding, and thromboembolic events among others. Read More

    Early cutaneous eruptions after oral hydroxychloroquine in a lupus erythematosus patient: A case report and review of the published work.
    J Dermatol 2017 Dec 14. Epub 2017 Dec 14.
    Department ofDermatology, Kansai Medical University, Hirakata, Japan.
    Hydroxychloroquine (HCQ) is an effective treatment of lupus erythematosus. Although adverse effects, mainly gastrointestinal and cutaneous manifestations, are rare, they may result in the cessation of medication in some patients with severe reactions. Therefore, the evaluation of a patient's condition is important for a dermatologist to decide whether to cease or continue HCQ. Read More

    How to identify DRESS, drug reaction with eosinophilia and systemic symptoms?
    Duodecim 2017;133(1):43-51
    DRESS (drug reaction with eosinophilia and systemic symptoms) is a rare, severe multiorgan adverse drug reaction. Antiepileptic age's and antibiotics are the most frequently reported causative agents. Compared with other drug reactions, DRESS demonstrates a long latency period thus complicating recognition and diagnosis. Read More

    Acute generalized exanthematous pustulosis induced by hydroxychloroquine: a case with atypical clinical presentation.
    An Bras Dermatol 2017 May-Jun;92(3):404-406
    Department of Pathology, Okmeydani Training and Research Hospital - Istanbul, Turkey.
    Acute generalized exanthematous pustulosis is a rare drug-induced eruption that is characterized by acute, nonfollicular sterile pustules on an erythematous and edematous base. The most frequently implicated drugs are beta-lactam antibiotics. Hydroxychloroquine has been widely used to treat dermatologic and rheumatologic diseases and has been reported as a rare cause of acute generalized exanthematous pustulosis. Read More

    Efficacy and safety of regorafenib in the treatment of metastatic colorectal cancer: A systematic review.
    Cancer Treat Rev 2018 Jan 10;62:61-73. Epub 2017 Nov 10.
    Department of Oncology, Herlev and Gentofte Hospital, University of Copenhagen, Herlev Ringvej 75, DK- 2730 Herlev, Denmark. Electronic address:
    Purpose: Despite advances in the treatment of colorectal cancer, third-line treatment options are still limited. Regorafenib was approved in 2012 for the treatment of patients with metastatic colorectal cancer previously treated with approved standard therapy. The purpose of this review is to present existing clinical data on regorafenib. Read More

    Dyshidrosiform pemphigoid localized on the hands in a child: a rare occurrence.
    An Bras Dermatol 2017 Sep-Oct;92(5):714-716
    Pt. B. D. Sharma, Post Graduate Institute of Medical Sciences - Rohtak- Haryana, India.
    Dyshidrosiform pemphigoid is an acquired autoimmune variant of bullous pemphigoid with persistent vesicobullous eruptions localized on the palms or soles, or both. It generally occurs in the elderly and is rarely reported in childhood. Hereby, we describe the first case of dyshidrosiform pemphigoid in a 12-year-old child, which was limited to the dorsal hands and treated successfully with dapsone (diaminodiphenyl sulfone). Read More

    Stevens-Johnson syndrome and toxic epidermal necrolysis: epidemiological and clinical outcomes analysis in public hospitals.
    An Bras Dermatol 2017 Sep-Oct;92(5):661-667
    Stricto Sensu Postgraduate Program In Health Sciences of Fundação de Ensino e Pesquisa em Ciências da Saúde (FEPECS) - Brasília (DF), Brazil.
    Background: Adverse drug reactions are harmful and involuntary responses to drugs that occur at doses normally used for a given condition. Among them are Stevens-Johnson syndrome and toxic epidermal necrolysis, both rare and potentially fatal conditions.

    Objectives: To analyze the epidemiological and clinical characteristics related to patients diagnosed with Stevens-Johnson syndrome and toxic epidermal necrolysis in public hospitals in the Federal District - Brazil. Read More

    A pilot study evaluating biomarker development for drug-induced chronic eczematous eruptions of aging individuals.
    Ann Transl Med 2017 Oct;5(20):393
    Department of Dermatology, University of Utah School of Medicine, Salt Lake City, UT, USA.
    Background: Identifying the drug(s) responsible for drug-induced chronic eczematous eruptions of aging individuals (CEEA) is a clinical challenge in patients on multiple medications. Reliabletesting methods and biomarkers are needed to identify the causative agent and allow simultaneous assessment of T-cell responses to multiple drugs being taken concurrently. This study examined the feasibility of using, drug-specific T cell activation responses as a biomarker for drug-induced CEEA. Read More

    Ichthyosiform Pityriasis Rubra Pilaris-Like Eruption Secondary to Ponatinib Therapy: Case Report and Literature Review.
    Drug Saf Case Rep 2017 Nov 14;4(1):19. Epub 2017 Nov 14.
    Department of Dermatology and Cutaneous Surgery, Jackson Memorial Hospital, University of Miami Miller School of Medicine, 1475 NW 12th Avenue, Miami, FL, 33136, USA.
    Tyrosine kinase inhibitors have revolutionized the chemotherapy arena as targeted therapies for a multitude of malignancies. They are more selective than conventional chemotherapy, and often elicit fewer systemic adverse events, however toxicities still exist. Cutaneous toxicities are common and their management presents a novel challenge to physicians and patients. Read More

    Delayed-type hypersensitivity to oral and parenteral drugs.
    J Dtsch Dermatol Ges 2017 Nov;15(11):1111-1132
    Allergy Unit, Department of Dermatology, Basel University Hospital, Basel, Switzerland.
    Adverse drug reactions of the delayed type rank among the most common dermatoses and are predominantly characterized by exanthematous macular or maculopapular eruptions. However, approximately 2 % of affected individuals develop severe or even life-threatening systemic immune reactions associated with organ involvement, requiring immediate diagnosis and treatment. Numerous drugs are capable of eliciting delayed-type hypersensitivity reactions, with antibiotics, anticonvulsant drugs, and the xanthine oxidase inhibitor allopurinol being the most common. Read More

    Serious infusion-related reaction after rituximab, abatacept and tocilizumab in rheumatoid arthritis: prospective registry data.
    Rheumatology (Oxford) 2018 Jan;57(1):134-139
    Rheumatology Department, National Center for Rare Systemic Autoimmune Diseases, Hôpitaux Universitaires de Strasbourg, Strasbourg.
    Objective: The aim was to evaluate the incidence of serious infusion-related reactions (SIRRs) in RA treated by non-TNF-targeted biologics.

    Methods: We analysed data from three independent prospective registers, namely autoimmunity and rituximab, Orencia (abatacept) and RA (ORA) and Registry RoAcTEmra (tocilizumab), promoted by the French Society of Rheumatology and including patients with RA. SIRRs were defined by an occurrence during or within 24 h of an infusion and requiring discontinuation of treatment. Read More

    Life-Threatening Atypical Case of Acute Generalized Exanthematous Pustulosis.
    Int Arch Allergy Immunol 2017 25;174(2):108-111. Epub 2017 Oct 25.
    Departmens of Dermatology, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany.
    Antibiotics are known to cause severe cutaneous adverse reactions, such as the rare acute generalized exanthematous pustulosis (AGEP). Unlike Stevens-Johnson syndrome or toxic epidermal necrolysis, AGEP is rarely life-threatening. Systemic involvement is not typical, and if present usually coincides with a mild elevation of the hepatic enzymes and a decrease in renal function. Read More

    [The major SCAR syndromes].
    Rev Med Liege 2017 Oct;72(10):444-447
    Service de Dermatopathologie et Consultant Service de Dermatologie, CHU de Liège, site du Sart Tilman, Liège, Belgique.
    Some drug eruptions are frequent and follow an indolent course, while others prove to be life-threatening. By contrast, SCAR syndromes are serious skin drug reactions that are rare but their vital prognosis is affected. The three distinct entities of importance are the former Lyell's syndrome, now identified as SJS-TEN syndrome (Stevens-Johnson syndrome/toxic epidermal necrolysis), the DRESS syndrome (drug reaction with eosinophilia and systemic symptoms), and the AGEP syndrome (acute generalized exanthematous pustulosis). Read More

    Liposomalization of oxaliplatin induces skin accumulation of it, but negligible skin toxicity.
    Toxicol Appl Pharmacol 2017 12 17;337:76-84. Epub 2017 Oct 17.
    Department of Environmental Biochemistry, Kyoto Pharmaceutical University, 5 Nakauchi-cho, Misasagi, Yamashina-ku, Kyoto 607-8414, Japan. Electronic address:
    Liposomalization causes alteration of the pharmacokinetics of encapsulated drugs, and allows delivery to tumor tissues through passive targeting via an enhanced permeation and retention (EPR) effect. PEGylated liposomal doxorubicin (Doxil, Lipo-DXR), a representative liposomal drug, is well-known to reduce cardiotoxicity and increase the anti-tumor activity of DXR, but to induce the hand-foot syndrome (HFS) as a result of skin DXR accumulation, which is one of its severe adverse effects. We have developed a new liposomal preparation of oxaliplatin (l-OHP), an important anti-tumor drug for treatment of colorectal cancer, using PEGylated liposomes (Lipo-l-OHP), and showed that Lipo-l-OHP exhibits increased anti-tumor activity in tumor-bearing mice compared to the original preparation of l-OHP. Read More

    High interpatient variability of treosulfan exposure is associated with early toxicity in paediatric HSCT: a prospective multicentre study.
    Br J Haematol 2017 12 19;179(5):772-780. Epub 2017 Oct 19.
    Department of Paediatrics, Leiden University Medical Centre, Leiden, the Netherlands.
    Treosulfan-based conditioning is increasingly employed in paediatric haematopoietic stem cell transplantation (HSCT). Data on treosulfan pharmacokinetics in children are scarce, and the relationship between treosulfan exposure, toxicity and clinical outcome is unresolved. In this multicentre prospective observational study, we studied treosulfan pharmacokinetics and the drug's relationship with regimen-related toxicity and early clinical outcome in 77 paediatric patients. Read More

    Clinico-pathological features of erythema nodosum leprosum: A case-control study at ALERT hospital, Ethiopia.
    PLoS Negl Trop Dis 2017 Oct 13;11(10):e0006011. Epub 2017 Oct 13.
    London School of Hygiene and Tropical Medicine (LSHTM), London, United Kingdom.
    Background: Leprosy reactions are a significant cause of morbidity in leprosy population. Erythema nodosum leprosum (ENL) is an immunological complication affecting approximately 50% of patients with lepromatous leprosy (LL) and 10% of borderline lepromatous (BL) leprosy. ENL is associated with clinical features such as skin lesions, neuritis, arthritis, dactylitis, eye inflammation, osteitis, orchitis, lymphadenitis and nephritis. Read More

    Lupus-like cutaneous reaction following pembrolizumab: An immune-related adverse event associated with anti-PD-1 therapy.
    J Cutan Pathol 2018 Jan 10;45(1):74-77. Epub 2017 Nov 10.
    Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
    PD-1 (programmed cell death-1) inhibitors, used to treat metastatic melanoma and other malignancies, are associated with development of immune-related adverse events in the skin. Such reactions include morbilliform eruptions, vitiligo, alopecia areata and bullous pemphigoid. In this report, we describe a patient who developed a lupus-like cutaneous reaction in the setting of pembrolizumab therapy for metastatic melanoma, adding to the spectrum of reactions which may be observed in association with PD-1 inhibitor therapy. Read More

    The risk of Stevens-Johnson syndrome and toxic epidermal necrolysis in new users of antiepileptic drugs.
    Epilepsia 2017 12 13;58(12):2178-2185. Epub 2017 Oct 13.
    Basel Pharmacoepidemiology Unit, Division of Clinical Pharmacy and Epidemiology, Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland.
    Objective: Older antiepileptic drugs (AEDs) are known to cause Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS/TEN). However, evidence for newer AED is sparse. We quantified risks of SJS/TEN in association with use of all AEDs in the United Kingdom. Read More

    Blistering rash in a young male child.
    S Afr Med J 2017 Jun 30;107(7):578-580. Epub 2017 Jun 30.
    Paediatrics Department, Leratong Hospital, Johannesburg, South Africa.
    A 3-year-old child was brought to the casualty department at Leratong Hospital, Johannesburg, South Africa, with severe bullous eruptions on the distal portions of both the upper and lower limbs. He had visited three different general practitioners prior to presentation and had been given several drugs and ointments, including three different classes of antibiotics. During his admission, the diagnosis of linear IgA bullous dermatitis was made. Read More

    Fever, rash, and leukopenia in a 32-year-old man · Dx?
    J Fam Pract 2017 Oct;66(10):E7-E10
    Department of Research, Fort Bragg, NC, USA.
    A 32-year-old man was admitted to our hospital with fever, chills, malaise, leukopenia, and a rash. About 3 weeks earlier, he'd had oral maxillofacial surgery and started a 10-day course of prophylactic amoxicillin/clavulanic acid. Fifteen days after the surgery, he developed a fever (temperature, 103° F), chills, arthralgia, myalgia, cough, diarrhea, and malaise. Read More

    T-cell regulation in Erythema Nodosum Leprosum.
    PLoS Negl Trop Dis 2017 Oct 9;11(10):e0006001. Epub 2017 Oct 9.
    London School of Hygiene and Tropical Medicine (LSHTM), Faculty of Infectious Tropical Diseases, London, United Kingdom.
    Leprosy is a disease caused by Mycobacterium leprae where the clinical spectrum correlates with the patient immune response. Erythema Nodosum Leprosum (ENL) is an immune-mediated inflammatory complication, which causes significant morbidity in affected leprosy patients. The underlying cause of ENL is not conclusively known. Read More

    Antimalarial drug toxicities in patients with cutaneous lupus and dermatomyositis: A retrospective cohort study.
    J Am Acad Dermatol 2018 Jan 6;78(1):100-106.e1. Epub 2017 Oct 6.
    Corporal Michael J. Crescenz Veterans Affairs Medical Center, Philadelphia, Pennsylvania; Department of Dermatology, Perelman School of Medicine, the University of Pennsylvania, Philadelphia, Pennsylvania. Electronic address:
    Background: Although existing evidence demonstrates the efficacy of antimalarials for rheumatic skin disease, the safety of these medications, and particularly quinacrine, remains debated.

    Objective: We investigated the toxicity risk associated with antimalarials in patients with cutaneous lupus erythematosus and dermatomyositis.

    Methods: A total of 532 patients (mean age, 52. Read More

    Intracorneal pustular drug eruption, a novel cutaneous adverse event in anti-programmed cell death-1 patients that highlights the effect of anti-programmed cell death-1 in neutrophils.
    Melanoma Res 2017 Dec;27(6):641-644
    aDepartment of Dermatology bDepartment of Pathology, Institute for Clinical Pathology and Medical Research, Westmead Hospital cDepartment of Dermatology, Faculty of Medicine, University of Sydney, Sydney, New South Wales, Australia.
    The introduction of anti-programmed cell death-1 (anti-PD1) monoclonal antibodies has revolutionized the treatment of various advanced malignancies. Despite its efficacy, anti-PD1 therapy is accompanied by a variety of cutaneous adverse events. A 79-year-old man developed erythematous scaly plaques and pustules of the forehead, legs and arms after four cycles of nivolumab infusions every 2 weeks. Read More

    Herpes Labialis: An Update.
    Recent Pat Inflamm Allergy Drug Discov 2017 ;11(2):107-113
    Toronto Dermatology Centre, Toronto, Ontario. Canada.
    Background: Herpes labialis is characterized by recurrent vesicular eruptions primarily on the lips and perioral skin. The condition is contagious, can cause significant discomfort/pain, and can have an adverse effect on the quality of life.

    Objective: To update the evaluation and treatment of herpes labialis. Read More

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