5,439,333 results match your criteria Drug Discovery Today incorporating Pharmaceutical Science and Technology Today[Journal]

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Ethanol-induced conditioned place preference and aversion differentially alter plasticity in the bed nucleus of stria terminalis.

Neuropsychopharmacology 2019 Feb 22. Epub 2019 Feb 22.

Department of Pharmacology, Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, Thurston Bowles Building 104 Manning Drive, Chapel Hill, NC, 27599, USA.

Contextual cues associated with drugs of abuse, such as ethanol, can trigger craving and drug-seeking behavior. Pavlovian procedures, such as place conditioning, have been widely used to study the rewarding/aversive properties of drugs and the association between environmental cues and drug seeking. Previous research has shown that ethanol as an unconditioned stimulus can induce a strong conditioned place preference (CPP) or aversion (CPA) in rodents. Read More

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http://dx.doi.org/10.1038/s41386-019-0349-0DOI Listing
February 2019

A transferrin receptor-binding mucoadhesive elastin-like recombinamer: in vitro and in vivo characterization.

Acta Biomater 2019 Feb 19. Epub 2019 Feb 19.

BIOFORGE (Group for Advanced Materials and Nanobiotechnology), CIBER-BBN, University of Valladolid, Paseo de Belén 19, 47011, Spain. Electronic address:

The development of mucoadhesive materials is of great interest and is also a major challenge. Being adsorption sites, mucosae are suitable targets for drug delivery, but as defensive barriers they are complex biological surfaces to interact with, mainly due to their protective mucus layer. As such, first- and second-generation mucoadhesives focused on material-mucus interactions, whereas the third generation of mucoadhesives introduced structural motifs that are able to interact with the cells beneath the mucus layer. Read More

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http://dx.doi.org/10.1016/j.actbio.2019.02.027DOI Listing
February 2019

Vitamin D-binding protein-loaded PLGA nanoparticles suppress Alzheimer's disease-related pathology in 5XFAD mice.

Nanomedicine 2019 Feb 19. Epub 2019 Feb 19.

Department of Biochemistry, College of Medicine, Konyang University, Daejeon, Republic of Korea. Electronic address:

The aggregation and accumulation of amyloid beta (Aβ) peptide is believed to be the primary cause of Alzheimer's disease (AD) pathogenesis. Vitamin D-binding protein (DBP) can attenuate Aβ aggregation and accumulation. A biocompatible polymer poly (-lactic acid-co-glycolic acid) (PLGA) can be loaded with therapeutic agents and control the rate of their release. Read More

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http://dx.doi.org/10.1016/j.nano.2019.02.004DOI Listing
February 2019

Genotypic and Phenotypic Characterization of Candida albicans Lebanese Hospital Isolates Resistant and Sensitive to Caspofungin.

Fungal Genet Biol 2019 Feb 19. Epub 2019 Feb 19.

Department of Natural Sciences, Lebanese American University, PO Box 36, Byblos, Lebanon(1). Electronic address:

The fungus Candida albicans is both a commensal and an opportunistic human pathogen, present as part of the normal human microflora causing serious mucosal, and systemic life threatening infections. The antifungal drug caspofungin of the echinocandin family is the latest generation of antifungal drugs to be developed. It functions by inhibiting glucan synthase thus weakening the fungal cell wall leading to death. Read More

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http://dx.doi.org/10.1016/j.fgb.2019.02.008DOI Listing
February 2019

Treatment efficacy of drug-resistant tuberculosis in Bashkortostan, Russia: a retrospective cohort study.

Int J Infect Dis 2019 Feb 19. Epub 2019 Feb 19.

Institute of Genomics, University of Tartu, Tartu, Riia, 23b, Estonia. Electronic address:

Background: Russia, together with other former Soviet Union countries, is characterized by one of the highest burdens of drug-resistant tuberculosis. Published data on the drug-resistant tuberculosis for these countries are limited, and it is not clear whether current treatment regimens remain effective against constantly evolving drug-resistant strains.

Objectives: The aim of the study was to evaluate treatment efficacy of patients with multidrug-resistant (MDR), extensively drug-resistant (XDR) and drug-susceptible (DSTB) tuberculosis in the most populous region of Russia (Bashkortostan) that borders with Central Asia. Read More

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http://dx.doi.org/10.1016/j.ijid.2019.02.010DOI Listing
February 2019

Targeting ERK1/2 protein-serine/threonine kinases in human cancers.

Authors:
Robert Roskoski

Pharmacol Res 2019 Feb 19. Epub 2019 Feb 19.

Blue Ridge Institute for Medical Research, 3754 Brevard Road, Suite 116, Box 19, Horse Shoe, NC, 28742-8814, United States. Electronic address:

ERK1 and ERK2 are key protein kinases that contribute to the Ras-Raf-MEK-ERK MAP kinase signalling module. This pathway participates in the control of numerous processes including apoptosis, cell proliferation, the immune response, nervous system function, and RNA synthesis and processing. MEK1/2 activate human ERK1/2 by first catalyzing the phosphorylation of Y204/187 and then T202/185, both residues of which occur within the activation segment. Read More

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http://dx.doi.org/10.1016/j.phrs.2019.01.039DOI Listing
February 2019

Dihydrotanshinone exhibits an anti-inflammatory effect in vitro and in vivo through blocking TLR4 dimerization.

Pharmacol Res 2019 Feb 19. Epub 2019 Feb 19.

State Key Laboratory of Innovative Drug and Efficient Energy-Saving Pharmaceutical Equipment, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China. Electronic address:

Dihydrotanshinone (DHT), one of the major ingredients of Salvia miltiorrhiza Bunge (Danshen), displays many bioactivities. However, the activity and underlying mechanism of DHT in anti-inflammation have not yet been elucidated. In this study, we investigated the anti-inflammatory activity and molecular mechanism of action of DHT both in vitro and in vivo. Read More

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http://dx.doi.org/10.1016/j.phrs.2019.02.017DOI Listing
February 2019

The acyl-glucuronide metabolite of ibuprofen has analgesic and anti-inflammatory effects via the TRPA1 channel.

Pharmacol Res 2019 Feb 19. Epub 2019 Feb 19.

Department of Health Sciences, Section of Clinical Pharmacology and Oncology, University of Florence, Florence, Italy. Electronic address:

Ibuprofen is a widely used non-steroidal anti-inflammatory drug (NSAID) that exerts analgesic and anti-inflammatory actions. The transient receptor potential ankyrin 1 (TRPA1) channel, expressed primarily in nociceptors, mediates the action of proalgesic and inflammatory agents. Ibuprofen metabolism yields the reactive compound, ibuprofen-acyl glucuronide, which, like other TRPA1 ligands, covalently interacts with macromolecules. Read More

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http://dx.doi.org/10.1016/j.phrs.2019.02.019DOI Listing
February 2019

Using herbal medicine to target the "microbiota-metabolism-immunity" axis as possible therapy for cardiovascular disease.

Pharmacol Res 2019 Feb 19. Epub 2019 Feb 19.

Xiyuan Hospital, China Academy of Chinese Medical Sciences, Xiyuan Caochang 1, Beijing 100091, China. Electronic address:

The gut microbiota harvests nutrients from the host while making possible the digestion of complex nutrients and regulating and balancing the immune and metabolic functions. The microbiota itself, and the dysbiosis of the gut flora, are correlated to the onset and progress of diabetes, obesity, and atherosclerosis. Herbal medicine (HM) plays a role in modulating gut microbiota and is widely used in the prevention and treatment of cardiovascular disease (CVD) and its associated conditions, such as diabetes, obesity, and hyperlipidemia. Read More

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http://dx.doi.org/10.1016/j.phrs.2019.02.018DOI Listing
February 2019

An In Vitro elucidation of the antiaggregatory potential of Diosmin over thermally induced unfolding of hen egg white lysozyme; A preventive quest for lysozyme amyloidosis.

Int J Biol Macromol 2019 Feb 19. Epub 2019 Feb 19.

Protein Amyloid Research Laboratory, Interdisciplinary Biotechnology Unit, Aligarh Muslim University, Aligarh, UP 202002, India. Electronic address:

Protein misfolding diseases are associated with human pathologies. These neurodegenerative diseases remain challenging task for researchers because of their adverse effect on vital organs system. Lysozyme amyloidosis is also associated with multi-organ dysfunction. Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2019.02.107DOI Listing
February 2019

Drug repurposing for new, efficient, broad spectrum antivirals.

Virus Res 2019 Feb 19. Epub 2019 Feb 19.

Cell Structure Laboratory, National Center for Biotechnology, National Research Council, CNB-CSIC, Darwin 3, UAM, campus de Cantoblanco, 28049 Madrid, Spain. Electronic address:

Emerging viruses are a major threat to human health. Recent outbreaks have emphasized the urgent need for new antiviral treatments. For several pathogenic viruses, considerable efforts have focused on vaccine development. Read More

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http://dx.doi.org/10.1016/j.virusres.2019.02.011DOI Listing
February 2019

FAM134B promotes esophageal squamous cell carcinoma in vitro and its correlations with clinicopathologic features.

Hum Pathol 2019 Feb 19. Epub 2019 Feb 19.

Department of Cancer Molecular Pathology, School of Medicine, Griffith University, Gold Coast, Australia. Electronic address:

Family with sequence similarity 134, member B (FAM134B) is an autophagy regulator of endoplasmic reticulum first discovered to be involved in the pathogenesis of esophageal squamous cell carcinoma (ESCC). The present study examined the functional behavior of FAM134B in cancer cells and the association of FAM134B expression with clinicopathologic factors in patients with ESCC. Expression at both the mRNA and protein levels was investigated using real-time polymerase chain reaction and immunohistochemistry. Read More

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http://dx.doi.org/10.1016/j.humpath.2018.11.033DOI Listing
February 2019

Tumor PD-L1 expression in malignant pleural and peritoneal mesothelioma by Dako PD-L1 22C3 pharmDx and Dako PD-L1 28-8 pharmDx assays.

Hum Pathol 2019 Feb 19. Epub 2019 Feb 19.

Department of Pathology, University of Utah, 1950 Circle of Hope, Salt Lake City, UT 84112; ARUP Laboratories, 500 Chipeta Way, Salt Lake City, UT, 84108.

Malignant mesothelioma (MM) is an aggressive neoplasm with poor prognosis. The Dako PD-L1 22C3 and 28-8 pharmDx assays are approved by the US Food and Drug Administration (FDA) as companion and complementary diagnostics for the anti-PD-1 drugs pembrolizumab and nivolumab, respectively. Data from multiple clinical trials indicate that immunotherapy has anti-tumor activity in advanced malignant pleural (MPM) and peritoneal mesothelioma (MPeM). Read More

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http://dx.doi.org/10.1016/j.humpath.2019.02.001DOI Listing
February 2019

Identification of a quadruple mutation that confers tenofovir resistance in chronic hepatitis B patients.

J Hepatol 2019 Feb 19. Epub 2019 Feb 19.

Department of Pharmacology and Center for Cancer Research and Diagnostic Medicine, IBST, School of Medicine, Konkuk University, Seoul, Korea; KU Open Innovation Center, Konkuk University, Seoul, Korea; Research Institute of Medical Sciences, Konkuk University, Seoul, Korea. Electronic address:

Background & Aims: Tenofovir disoproxil fumarate (TDF) is one the most potent nucleot(s)ide analogues for treating chronic hepatitis B virus (HBV) infection. Phenotypic resistance caused by genotypic resistance to TDF has not been reported. This study aimed to characterize HBV mutations that confer tenofovir resistance. Read More

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http://dx.doi.org/10.1016/j.jhep.2019.02.006DOI Listing
February 2019

Influence of traditionally used Nepalese plants on wound healing and immunological properties using primary human cells in vitro.

J Ethnopharmacol 2019 Feb 19. Epub 2019 Feb 19.

Centre for Complementary Medicine, Institute for Infection Prevention and Hospital Epidemiology, Faculty of Medicine, University of Freiburg, Breisacher Straße 115 B, 79106 Freiburg, Germany. Electronic address:

Ethnopharmacological Relevance: The improvement of wound healing has always been an important issue for both ethnopharmacological and modern medical research. In this study, we used state-of-the-art methods to investigate extracts of plants used traditionally in Nepal for more than 1,000 years to treat inflammatory skin injuries.

Aim Of The Study: We focused on the potential of the plant extracts to ameliorate wound healing and to influence immune modulatory properties. Read More

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http://dx.doi.org/10.1016/j.jep.2019.02.034DOI Listing
February 2019

Capturing and applying knowledge to guide compound optimisation.

Drug Discov Today 2019 Feb 19. Epub 2019 Feb 19.

Optibrium Limited, F5-6 Blenheim House, Cambridge Innovation Park, Denny End Road, Cambridge, CB25 9PB, UK.

Successful drug discovery requires knowledge and experience across many disciplines, and no current 'artificial intelligence' (AI) method can replace expert scientists. However, computers can recall more information than any individual or team and facilitate the transfer of knowledge across disciplines. Here, we discuss how knowledge relating to chemistry and the biological and physicochemical properties required for a successful compound can be captured. Read More

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http://dx.doi.org/10.1016/j.drudis.2019.02.004DOI Listing
February 2019

E-drug delivery: a futuristic approach.

Drug Discov Today 2019 Feb 19. Epub 2019 Feb 19.

Shobhaben Pratapbhai Patel School of Pharmacy & Technology Management, Svkm's NMIMS Deemed to be University, Vile-Parle (W), Mumbai 400056, India. Electronic address:

Drug delivery systems are undergoing technology changes to enhance patient comfort and compliance. Electronic drug delivery (E-drug delivery) systems are being developed to regulate drug dose delivery by easy monitoring of doses, especially in chronic and age-related diseases. E-drug delivery can monitor the correct dose of anesthesia and could be used in GI tracking by E-capsules and in epilepsy, insulin drug delivery, cardiac ailments and cancer therapy. Read More

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http://dx.doi.org/10.1016/j.drudis.2019.02.005DOI Listing
February 2019

Anti-cancer effect of Indanone-based thiazolyl hydrazone derivative on colon cancer cell lines.

Int J Biochem Cell Biol 2019 Feb 19. Epub 2019 Feb 19.

Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, St. John's University, Queens, NY, 11439, USA. Electronic address:

Colorectal cancer is the third leading cause of cancer related deaths in the United States. Currently, Irinotecan, a topoisomerase I inhibitor, is an approved anti-cancer drug for the treatment of patients with advanced or recurrent colorectal cancer. Considering low response rate and events of high toxicity caused by irinotecan, we evaluated a series of thirteen thiazolyl hydrazone derivatives of 1-indanone for their potential antineoplastic activity and four compounds showed promising anti-cancer activity against most of the tested colon cancer cell lines with IC values ranging from 0. Read More

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http://dx.doi.org/10.1016/j.biocel.2019.02.004DOI Listing
February 2019

Enrichment-induced differences in methamphetamine drug discrimination in male rats.

Pharmacol Biochem Behav 2019 Feb 19. Epub 2019 Feb 19.

Creighton University, Department of Psychological Science, United States of America. Electronic address:

Rats raised in an enriched environment show a decrease in sensitivity to the subjective effects of the psychostimulant d-amphetamine. The purpose of the present study was to determine if environmental enrichment during development alters the subjective effects of the more commonly abused drug methamphetamine. Male Sprague-Dawley rats were raised in either an enriched (EC) or an isolated condition (IC). Read More

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http://dx.doi.org/10.1016/j.pbb.2019.02.008DOI Listing
February 2019

Triclosan-loaded chitosan as antibacterial agent for adhesive resin.

J Dent 2019 Feb 19. Epub 2019 Feb 19.

Dental Materials Laboratory, School of Dentistry, Federal University of Rio Grande do Sul, Rua Ramiro Barcelos, 2492, Rio Branco, 90035-003, Porto Alegre, RS, Brazil. Electronic address:

Objectives: The aim of this study was to formulate and to evaluate the immediate and long-term physical, chemical and antibacterial properties of an experimental adhesive resin with chitosan or triclosan-loaded chitosan.

Materials And Methods: Chitosan, triclosan and triclosan-loaded chitosan were evaluated for scanning electron microscopy (SEM) and micro-Raman spectroscopy. An experimental adhesive resin was formulated with methacrylate monomers and photoinitiators. Read More

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http://dx.doi.org/10.1016/j.jdent.2019.02.002DOI Listing
February 2019

Reductively cleavable polymer-drug conjugates based on dendritic polyglycerol sulfate and monomethyl auristatin E as anticancer drugs.

J Control Release 2019 Feb 19. Epub 2019 Feb 19.

Institute for Chemistry and Biochemistry, Freie Universität Berlin, Takustr. 3, Berlin 14195, Germany. Electronic address:

Stimuli-responsive polymer-drug conjugates (PDCs) provide promising approaches in anticancer treatment. Here, we report the synthesis and biological evaluation of PDCs made of the highly potent antimitotic agent monomethyl auristatin E conjugated to dendritic polyglycerol and dendritic polyglycerol sulfate via a reductively cleavable, self-immolative disulfide linker. Cell viability assays with the human cancer cell lines A549 (lung carcinoma) and HeLa (cervix carcinoma) revealed that the drug's cytotoxicity was reduced by conjugation to the polymers, with the sulfated conjugates being more effective than the non-sulfated ones. Read More

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http://dx.doi.org/10.1016/j.jconrel.2019.01.035DOI Listing
February 2019

Engineered materials to model human intestinal development and cancer using organoids.

Exp Cell Res 2019 Feb 19. Epub 2019 Feb 19.

Parker H. Petit Institute for Bioengineering and Biosciences, Georgia Institute of Technology, Atlanta, GA 30332; George W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA 30332. Electronic address:

Human organoids provide constructive in vitro models of human development and disease, as these recapitulate important morphogenetic and functional features of the tissue and species of origin. However, organoid culture technologies often involve the use of biologically-derived materials (e.g. Read More

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http://dx.doi.org/10.1016/j.yexcr.2019.02.017DOI Listing
February 2019

Validation of Human MDR1-MDCK and BCRP-MDCK Cell Lines to Improve the Prediction of Brain Penetration.

J Pharm Sci 2019 Feb 19. Epub 2019 Feb 19.

It is of great challenge to predict human brain penetration for substrates of multidrug resistance protein 1 (MDR1) and/or breast cancer resistance protein (BCRP), two major efflux transporters at blood-brain barrier. Thus, a PBPK model with the incorporation of in vitro MDR1 and BCRP transporter function data and transporter protein expression levels has been developed. As such, it is crucial to generate MDR1 and BCRP substrate data with a high fidelity. Read More

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http://dx.doi.org/10.1016/j.xphs.2019.02.005DOI Listing
February 2019

Innovation in Chemistry, Manufacturing, and Controls - A Regulatory Perspective From Industry.

J Pharm Sci 2019 Feb 19. Epub 2019 Feb 19.

Regulatory Affairs CMC, Amgen Inc., Thousand Oaks, CA, USA.

This review describes the landscape of novel modalities such as cell and gene therapies, viruses, other novel biologics, oligomers, and emerging technologies, including modern analytics. We summarize the regulatory history and recent landmark developments in some major markets and examine specific chemistry, manufacturing, and controls (CMC) challenges, including suggestions for exploration of potential science-based approaches in support of regulatory strategy development from an industry perspective. Additionally, we evaluate the economic factors contributing to patient access to innovation and discuss the impact of regulation. Read More

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http://dx.doi.org/10.1016/j.xphs.2019.02.007DOI Listing
February 2019

CCR5 Is a Therapeutic Target for Recovery after Stroke and Traumatic Brain Injury.

Cell 2019 Feb;176(5):1143-1157.e13

Department of Neurology, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095, USA. Electronic address:

We tested a newly described molecular memory system, CCR5 signaling, for its role in recovery after stroke and traumatic brain injury (TBI). CCR5 is uniquely expressed in cortical neurons after stroke. Post-stroke neuronal knockdown of CCR5 in pre-motor cortex leads to early recovery of motor control. Read More

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http://dx.doi.org/10.1016/j.cell.2019.01.044DOI Listing
February 2019

Acute Corticosterone Treatment Elicits Antidepressant-like Actions on the Hippocampal 5-HT and the Immobility Phenotype.

Brain Res 2019 Feb 19. Epub 2019 Feb 19.

Department of Clinical Pharmacology, School of Pharmacy, China Medical University, Shenyang, 110122, China. Electronic address:

Corticosterone (CORT) has long been shown to modulate 5-HT system, and to alter hippocampal functions in various physiological and pathological conditions. However, CORT-elicited changes in the hippocampal 5-HT transmission and the immobility phenotype had not been fully addressed. The current study sought to explore effects of acute CORT subcutaneously injected at 10, 20, 40 mg/kg on the extracellular 5-HT in the hippocampus and the immobility time in male CD-1 mice. Read More

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http://dx.doi.org/10.1016/j.brainres.2019.02.022DOI Listing
February 2019

Real-world misuse, abuse, and dependence of abuse deterrent versus non-abuse-deterrent extended-release morphine in Medicaid non-cancer patients.

Postgrad Med 2019 Feb 22. Epub 2019 Feb 22.

h Pfizer Inc - Medical Affairs.

Objective: Opioids with abuse-deterrent properties may reduce widespread abuse, misuse, and diversion of these products. This study aimed to quantify misuse, abuse, dependence, and health resource use of extended-release morphine sulfate with sequestered naltrexone hydrochloride (ER-MSN; EMBEDA®), compared with non-abuse-deterrent extended-release morphine (ERM) products in Medicaid non-cancer patients.

Methods: Administrative medical and pharmacy claims data were analyzed for 10 Medicaid states from January 1, 2015, to June 30, 2016. Read More

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http://dx.doi.org/10.1080/00325481.2019.1585688DOI Listing
February 2019

Predatory journals: Do not judge journals by their Editorial Board Members.

Med Teach 2019 Feb 22:1-6. Epub 2019 Feb 22.

c Laboratory of NeuroPsychiatric Genetics, Biomedical Sciences Research Group, School of Medicine , Universidad Antonio Nariño , Bogotá , Colombia.

Objective: Given that often the quality of journals is based on its editors, the objective of this study was to describe quantitatively the profiles of members of editorial boards (MEBs) of presumed predatory journals.

Methods: The following information was retrieved from 1015 editors taken from journals listed in Beall's list: country, university, position, and degree. The Scopus website was used to identify the number of citations, documents, and h-index. Read More

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http://dx.doi.org/10.1080/0142159X.2018.1556390DOI Listing
February 2019

Atrial fibrillation and cardiac rehabilitation: an overview.

Acta Cardiol 2019 Feb 22:1-5. Epub 2019 Feb 22.

b Department of Cardiology , Clinique Saint Luc Bouge , Namur , Belgium.

Background: Atrial fibrillation (AF) is the most common cardiac arrhythmia, and its frequency will only continue to increase in the future. Despite available drug and electrophysical treatments, death and functional restrictions due to AF are still common. More comprehensive standards of care are therefore needed. Read More

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http://dx.doi.org/10.1080/00015385.2019.1565663DOI Listing
February 2019

Antibiotic treatment-induced dysbiosis differently affects BDNF and TrkB expression in the brain and in the gut of juvenile mice.

PLoS One 2019 22;14(2):e0212856. Epub 2019 Feb 22.

Department of Medicine and Surgery, University of Insubria, Varese, Italy.

Antibiotic use during adolescence may result in dysbiosis-induced neuronal vulnerability both in the enteric nervous system (ENS) and central nervous system (CNS) contributing to the onset of chronic gastrointestinal disorders, such as irritable bowel syndrome (IBS), showing significant psychiatric comorbidity. Intestinal microbiota alterations during adolescence influence the expression of molecular factors involved in neuronal development in both the ENS and CNS. In this study, we have evaluated the expression of brain-derived neurotrophic factor (BDNF) and its high-affinity receptor tropomyosin-related kinase B (TrkB) in juvenile mice ENS and CNS, after a 2-week antibiotic (ABX) treatment. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212856PLOS
February 2019

Economic burden of lung cancer: A retrospective cohort study in South Korea, 2002-2015.

PLoS One 2019 22;14(2):e0212878. Epub 2019 Feb 22.

College of Pharmacy and Research Institute of Pharmaceutical Sciences, Kyungpook National University, Daegu, South Korea.

We evaluated the survival rates and medical expenditure in patients with lung cancer using a nationwide claims database in South Korea. A retrospective observational cohort study design was used, and 2,919 lung cancer patients and their matched controls were included. Medical expenditures were analyzed with the Kaplan-Meier sample average method, and patients were categorized into 4 groups by operation and primary treatment method (i. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212878PLOS
February 2019

The use of tail-anchored protein chimeras to enhance liposomal cargo delivery.

PLoS One 2019 22;14(2):e0212701. Epub 2019 Feb 22.

Division of Pharmacy and Optometry, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, United Kingdom.

Background: Liposomes are employed as drug delivery vehicles offering a beneficial pharmacokinetic/distribution mechanism for in vivo therapeutics. Therapeutic liposomes can be designed to target specific cell types through the display of epitope-specific targeting peptides on their surface. The majority of peptides are currently attached by chemical modification of lipid constituents. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212701PLOS
February 2019

ASB20123: A novel C-type natriuretic peptide derivative for treatment of growth failure and dwarfism.

PLoS One 2019 22;14(2):e0212680. Epub 2019 Feb 22.

National Cerebral and Cardiovascular Center Research Institute, Osaka, Japan.

C-type natriuretic peptide (CNP) and its receptor natriuretic peptide receptor B (NPR-B) are physiological potent positive regulators of endochondral bone growth; therefore, the CNP/NPR-B signaling pathway is one of the most promising therapeutic targets for treating growth failure and dwarfism. In this article, we summarized the pharmacological properties of a novel CNP analog peptide ASB20123 as a therapeutic agent for short stature. ASB20123, one of the CNP/ghrelin chimeric peptides, is composed of CNP(1-22) and human ghrelin(12-28, E17D). Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212680PLOS
February 2019

Routine surveillance for the identification of drug resistant Tuberculosis in Tanzania: A cross-sectional study of stakeholders' perceptions.

PLoS One 2019 22;14(2):e0212421. Epub 2019 Feb 22.

Liverpool School of Tropical Medicine, Centre for Applied Health Research and Delivery, Liverpool, United Kingdom.

Background: Routine surveillance is required to monitor the performance of tuberculosis diagnostic programme and is essential for the rapid detection of drug resistance. The main objective of this study was to explore the effectiveness and stakeholder perception of the current routine surveillance system for previously treated tuberculosis cases in Tanzania with a view to identify interventions to improve and accelerate positive patient outcomes.

Methods: A study using quantitative and qualitative methods of data collection including in-depth interviews and focus group discussions with health care service providers was conducted in four regions. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212421PLOS
February 2019

A text-mining approach to obtain detailed treatment information from free-text fields in population-based cancer registries: A study of non-small cell lung cancer in California.

PLoS One 2019 22;14(2):e0212454. Epub 2019 Feb 22.

California Cancer Reporting and Epidemiologic Surveillance Program, Institute for Population Health Improvement, University of California Davis Health, Sacramento, California, United States of America.

Background: Population-based cancer registries have treatment information for all patients making them an excellent resource for population-level monitoring. However, specific treatment details, such as drug names, are contained in a free-text format that is difficult to process and summarize. We assessed the accuracy and efficiency of a text-mining algorithm to identify systemic treatments for lung cancer from free-text fields in the California Cancer Registry. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212454PLOS
February 2019

A management system for randomized clinical trials: A novel way to supply medication.

PLoS One 2019 22;14(2):e0212475. Epub 2019 Feb 22.

Department of Preventive & Predictive Medicine, Epidemiology Unit, Foundation IRCCS National Cancer Institute of Milan, Milan, Italy.

Background: Randomized controlled clinical trials require management effort, involving huge organizational, economic and informatics investments. Information technology offers opportunities to approach clinical trial methodology in new ways. However, there are only a few reports of computerized data and drug management systems. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212475PLOS
February 2019

Drug-induced sleep endoscopy-directed adenotonsillectomy in pediatric obstructive sleep apnea with small tonsils.

Authors:
Jie Chen Shan He

PLoS One 2019 22;14(2):e0212317. Epub 2019 Feb 22.

Department of Otolaryngology, Shanghai Children's Medical Center Affiliated with Shanghai Jiaotong University School of Medicine, Shanghai, China.

The study aims to examine drug-induced sleep endoscopy (DISE) in the decision-making process of pediatric obstructive sleep apnea (OSA) patients with small tonsils. This was a retrospective study of children who underwent awake flexible endoscopy, DISE, and adenoidectomy with/without tonsillectomy at the Shanghai Children's Medical Center between 03/2015 and 12/2016. Tonsillectomy was performed for tonsillar obstruction found by DISE. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212317PLOS
February 2019

Recording of Neural Activity with Modulation of Photolysis of Caged Compounds using Microelectrode Arrays in Rats with Seizures.

IEEE Trans Biomed Eng 2019 Feb 20. Epub 2019 Feb 20.

Objective: In this work, a new method was established to monitor multichannel neural activity with microelectrode arrays (MEAs) under modulation of caged compounds in a rat model of seizures.

Methods: The 16-channel MEAs were fabricated and implanted into the hippocampus of normal rats and epileptic rats for neural spike and local field potential (LFP) recording. Using optical fibers with drug delivery tubing, two different caged compounds (ruthenium-bipyridine-trimethylphosphine glutamate (RuBi-Glu) and ruthenium-bipyridine-trimethylphosphine gamma aminobutyric acid (RuBi-GABA)) were applied, and blue light (465 nm) was used to modulate neural activity. Read More

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http://dx.doi.org/10.1109/TBME.2019.2900251DOI Listing
February 2019

Drug treatment strategies for insomnia in patients with post-traumatic stress disorder.

Expert Opin Pharmacother 2019 Feb 22:1-9. Epub 2019 Feb 22.

b Department of Medicine , VA Western New York Healthcare System , Buffalo , NY , USA.

Introduction: Insomnia is among the most reported sleep disturbances in patients with post-traumatic stress disorder (PTSD). The pervasiveness of this disorder among trauma-inflicted civilians and military personnel has been associated with reduced quality of life, impaired psychosocial functioning including cognitive impairments, negative mood swings, cardiovascular complications, and increased utilization of medical services. Areas covered: This review describes the current state of science with respect to the impact of the most dispensed pharmacological interventions for posttraumatic insomnia. Read More

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http://dx.doi.org/10.1080/14656566.2019.1574745DOI Listing
February 2019

Overview of Leafy Greens-Related Food Safety Incidents with a California Link: 1996 to 2016.

J Food Prot 2019 Feb 21:405-414. Epub 2019 Feb 21.

2 Food and Drug Branch, California Department of Public Health, 1500 Capitol Avenue, Sacramento, California 95814.

An increase in the number of foodborne illness outbreaks associated with produce has been noted in the literature, and leafy greens have been the most common produce category associated with these outbreaks. California is the largest leafy greens producer in the United States, and many related foodborne illness incidents were traced to this state. A systematic overview of leafy greens incidents linked to California was conducted by the California Department of Public Health, Food and Drug Branch through analysis of complaints, routine surveillance sampling, disease outbreaks, and investigations covering 1996 to 2016. Read More

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http://dx.doi.org/10.4315/0362-028X.JFP-18-316DOI Listing
February 2019

DNA Microarray-Based Genomic Characterization of the Pathotypes of Escherichia coli O26, O45, O103, O111, and O145 Isolated from Feces of Feedlot Cattle .

J Food Prot 2019 Feb 21:395-404. Epub 2019 Feb 21.

1 Department of Diagnostic Medicine and Pathobiology, Kansas State University, Manhattan, Kansas 66506.

Shiga toxin-producing Escherichia coli (STEC) serogroups O26, O45, O103, O111, O121, and O145, referred to as the top six non-O157 serogroups, are responsible for more than 70% of human non-O157 STEC infections in North America. Cattle harbor non-O157 strains in the hindgut and shed them in the feces. The objective of this study was to use the U. Read More

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http://dx.doi.org/10.4315/0362-028X.JFP-18-393DOI Listing
February 2019

Application of the Mechanical High-Pressure Method Combined with High-Performance Liquid Chromatography-Tandem Mass Spectrometry for Determination of Veterinary Drug Residues in Incurred Chicken and Rabbit Muscle Tissues.

J Food Prot 2019 Feb 21:415-421. Epub 2019 Feb 21.

4 Chemistry and Chemical Engineering, Henan Institute of Science and Technology, Hualan Road, Xinxiang 453003, People's Republic of China.

Rapid sample preparation is a key step in the field of food safety. A mechanical high-pressure method using a laboratory-made meat press machine was first introduced in this study to process the incurred muscle samples of chicken and rabbit. By applying high pressure to animal muscle, the meat juice was obtained. Read More

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http://dx.doi.org/10.4315/0362-028X.JFP-18-386DOI Listing
February 2019

Mechanism of supersaturation suppression in dissolution process of acidic drug salt.

Mol Pharm 2019 Feb 22. Epub 2019 Feb 22.

Supersaturable active pharmaceutical ingredients (sAPI), such as salts, cocrystals, and amorphous solids, can form supersaturated solutions after dissolving in the gastrointestinal fluids. However, there are cases in which supersaturation is not observed in an in vitro non-sink dissolution test. The purpose of the present study was to investigate the mechanisms of supersaturation suppression in the dissolution process of acidic drug salts. Read More

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http://dx.doi.org/10.1021/acs.molpharmaceut.9b00006DOI Listing
February 2019

Discovering Putative Protein Targets of Small Molecules: A Study of the p53 Activator Nutlin.

J Chem Inf Model 2019 Feb 22. Epub 2019 Feb 22.

Small molecule drugs bind to a pocket in disease causing target proteins based on complementarity in shape and physicochemical properties. There is a likelihood that other proteins could have binding sites that are structurally similar to the target protein. Binding to these other proteins could alter their activities leading to off target effects of the drug. Read More

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http://dx.doi.org/10.1021/acs.jcim.8b00762DOI Listing
February 2019

Selectively oxidized cellulose with adjustable molecular weight for controlled release of platinum anticancer drugs.

Biomacromolecules 2019 Feb 22. Epub 2019 Feb 22.

The synthesis of selectively oxidized cellulose, 2,3-dicarboxycellulose (DCC), is optimized for preparation of highly oxidized material for biological applications, which includes control over the molecular weight of the product during its synthesis. Conjugates of DCC and cisplatin simultaneously offer a very high drug-binding efficiency (>90 %) and drug loading capacity (up to 50 wt.%), while retaining good aqueous solubility. Read More

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http://dx.doi.org/10.1021/acs.biomac.8b01807DOI Listing
February 2019

Interactions of an Anti-sickling Drug with Hemoglobin in Red Blood Cells from a Patient with Sickle Cell Anemia.

Bioconjug Chem 2019 Feb 22. Epub 2019 Feb 22.

The pathophysiology associated with sickle cell disease (SCD) includes hemolytic anemia, vaso-occlusive events, and ultimately end organ damage set off by the polymerization of deoxygenated hemoglobin S (HbS) into long fibers and sickling of red blood cells (RBCs). One approach toward mitigating HbS polymerization is to pharmacologically stabilize the oxygenated (R) con-formation of HbS and thereby reduce sickling frequency and SCD pathology. GBT440 is an α subunit specific modifying agent that has recently been reported to increase HbS oxygen binding affinity and consequently delay in vitro polymerization. Read More

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http://dx.doi.org/10.1021/acs.bioconjchem.9b00130DOI Listing
February 2019

Enzymatic Tagging of Glycoproteins on the Cell Surface for Their Global and Site-Specific Analysis with Mass Spectrometry.

Anal Chem 2019 Feb 22. Epub 2019 Feb 22.

The cell surface is normally covered with sugars that are bound to lipids or proteins. Surface glycoproteins play critically important roles in many cellular events, including cell-cell communications, cell-matrix interactions, and response to environmental cues. Aberrant protein glycosylation on the cell surface is often a hallmark of human diseases such as cancer and infectious diseases. Read More

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http://dx.doi.org/10.1021/acs.analchem.9b00441DOI Listing
February 2019

A Temperature-Gated Nanovalve Self-Assembled from DNA to Control Molecular Transport across Membranes.

ACS Nano 2019 Feb 22. Epub 2019 Feb 22.

Department of Chemistry, Institute of Structural and Molecular Biology , University College London , London , WC1H 0AJ , United Kingdom.

Nanopores are powerful nanodevices that puncture semifluid membranes to enable transport of molecular matter across biological or synthetic thin layers. Advanced nanopores featuring more complex functions such as ambient sensing and reversible channel opening are of considerable scientific and technological interest but challenging to achieve with classical building materials. Here we exploit the predictable assembly properties of DNA to form a multifunctional nanovalve that senses temperature for controlled channel opening and tunable transport. Read More

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http://dx.doi.org/10.1021/acsnano.8b09200DOI Listing
February 2019

3D-printed, externally-implanted, bioresorbable airway splints for severe tracheobronchomalacia.

Laryngoscope 2019 Feb 22. Epub 2019 Feb 22.

Department of Otolaryngology-Head and Neck Surgery, University of Michigan, Ann Arbor, Michigan.

Objectives/hypothesis: To report the clinical safety and efficacy of three-dimensional (3D)-printed, patient-specific, bioresorbable airway splints in a cohort of critically ill children with severe tracheobronchomalacia.

Study Design: Case series.

Methods: From 2012 to 2018, 15 subjects received 29 splints on their trachea, right and/or left mainstem bronchi. Read More

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http://dx.doi.org/10.1002/lary.27863DOI Listing
February 2019

Comment on "Revisiting the carrageenan controversy: do we really understand the digestive fate and safety of carrageenan in our foods?" by S. David, C. S. Levi, L. Fahoum, Y. Ungar, E. G. Meyron-Holtz, A. Shpigelman and U. Lesmes, Food Funct., 2018, 9, 1344-1352.

Food Funct 2019 Feb 22. Epub 2019 Feb 22.

IONTOX, LLC, 4717 Campus Dr., Kalamazoo, MI 49008, USA.

Carrageenan (CGN) is a polysaccharide that is found in various types of sea weed. It is a common food additive used for its gelling and thickening properties and has been used safely throughout the world for decades. CGN is approved as Generally Recognized as Safe (GRAS) by the United States Food and Drug Administration and is also considered safe for the general population by the World Health Organizations Joint Expert Committee on Food Additive (JECFA) and the European Food Safety Authority. Read More

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http://dx.doi.org/10.1039/c8fo01282bDOI Listing
February 2019
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