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Drug Dev Ind Pharm 2019 Feb 15:1-45. Epub 2019 Feb 15.

a School of Natural Product Studies, Department of Pharmaceutical Technology , Jadavpur University , Kolkata - 700032 , India.

Objective: To prepare and characterize an optimized phospholipid complex of Ursolic acid (UA) to overcome the poor pharmacokinetic properties and to investigate the impact of the complex on hepatoprotective activity and bioavailability in animal model.

Significance: UA is a potential phytoconstituent obtained from several plant sources, which has been explored for its diverse pharmacological activities including hepatoprotection. Its major limitation is poor absorption, rapid elimination and hence low bioavailability after administration. Read More

Drug Dev Ind Pharm 2019 Feb 15:1-26. Epub 2019 Feb 15.

a School of Biomedical Sciences, Faculty of medicine , The University of Queensland , St Lucia , 4072 , Australia.

Pulmonary infections the most common cause of death globally. However, the development of mucosal vaccines that provide protective immunity against respiratory pathogens are limited. In contrast to needle-based vaccines, efficient vaccines that are delivered via non-invasive mucosal routes (such as via the lungs and nasal passage) produce both antigen-specific local mucosal IgA and systemic IgG protective antibodies. Read More

Drug Dev Ind Pharm 2019 Feb 15:1-16. Epub 2019 Feb 15.

a School of Pharmacy , Shenyang Pharmaceutical University , Shenyang , 110016 , China.

In this work, aspirin sustained granules were prepared using micro-crystal coating and hot-melt granulation respectively. In the process of micro-crystal coating, PVP was used to form the isolation layer and then coated with either Eudragit RS/RL30D or ethyl cellulose (EC) as sustained-release layers to prepare sustained granules (the granules from this method were denoted m-cG). And in the process of hot-melt granulation, the granules were obtained with stearyl alcohol as a binder and EC as matrix material to prepare sustained granules (the granules were denoted h-mG). Read More

Drug Dev Ind Pharm 2019 Feb 15:1-37. Epub 2019 Feb 15.

a Shobhaben Pratapbhai Patel School of Pharmacy and Technology Management SVKM's NMIMS , V. L. Mehta Road , Vile Parle (W), Mumbai , India.

Among lipid-based nanocarriers, multi-layered cochleates emerge as a novel delivery system because of prevention of oxidation of hydrophobic and hydrophilic drugs, enhancement in permeability and reduction in dose of drugs. It also improves oral bioavailability and increases the safety of a drug by targeting at a specific site with less side effects. Nanostructured cochleates are used as a carrier for the delivery of water-insoluble or hydrophobic drugs of anti-cancer, antiviral and anti-inflammatory action. Read More

Drug Dev Ind Pharm 2019 Feb 14:1-13. Epub 2019 Feb 14.

a Department of Pharmaceutics , National Institute of Pharmaceutical Education & Research (NIPER) , Hyderabad , India ;

Objective: The aim of this study was to formulate nanostructured lipid carriers (NLCs) of dithranol-loaded in gel for ease of application and to evaluate its anti-psoriatic efficacy vis-a-vis conventional ointment formulation.

Significance: This study will provide an insight about the use of nanocarriers, esp. NLCs loaded with dithranol for the effective treatment of psoriasis. Read More

Drug Dev Ind Pharm 2019 Feb 11:1-25. Epub 2019 Feb 11.

a Guangdong Key Laboratory of New Dosage Forms of Drugs , Guangdong Pharmaceutical University , Guangzhou 510006 , China.

The aim of this study was to determine the effect of varying excipient content on the formation and physical properties of 3D printed tablets. Fifteen different excipient preparations were formed into tablets with radii of 5 mm and thickness of 2 mm, using binder jetting (BJ). The tablets were analyzed by assessing visual and microstructural appearance, friability, hardness, and disintegration time. Read More

Drug Dev Ind Pharm 2019 Feb 12:1-54. Epub 2019 Feb 12.

c Department of surgical pathology, Faculty of Medicine , Cairo University , Cairo , Egypt.

Objectives: This study was aimed to develop dual-purpose natamycin(NAT) loaded niosomes in ketorolac tromethamine(KT) gels topical ocular drug delivery system to improve the clinical efficacy of natamycin through enhancing its penetration through corneal tissue and reducing inflammation associated with Fungal keratitis(FK).

Significance: Nanosized carrier systems, as niosomes would provide great potential for improving NAT ocular bioavailability.NAT niosomal dispersion formulae were prepared and then incorporated in 0. Read More

Drug Dev Ind Pharm 2019 Feb 8:1-29. Epub 2019 Feb 8.

a Pharmaceutical Technology Unit , National Institute of Laser Enhanced Sciences (NILES), Cairo University , P.O. 12613 , Giza , Egypt.

This study introduces a simple method for one-step synthesis of highly stable non-toxic polymer-coated gold nanospheres for use in drug delivery, focuses on the ability of chloroauric acid to induce polyphenols polymerization, puts up an easy procedure for loading hydrophobic drugs onto gold nanoparticles with ultra-high loading efficiency and studies the cytotoxicity of free and gold nanoparticles-loaded resveratrol. Gold nanospheres were synthesized simply by direct reaction between resveratrol itself and chloroauric acid in aqueous medium. Synthesized gold nanospheres exhibited high stability in both aqueous and ethanolic solutions. Read More

Drug Dev Ind Pharm 2019 Feb 6:1-30. Epub 2019 Feb 6.

a Department of Pharmaceutics , Bombay College of Pharmacy , Mumbai , India.

The objective of the present investigation was to improve the skin deposition and retention of metronidazole (MTZ) in rosacea therapy, by incorporating it into nanostructured lipid carriers (NLCs). The main challenge in this endeavour was the partial hydrophilicity of MTZ, which mandated careful selection of excipients, including solid and liquid lipids, surfactants, and their ratios in combination. NLCs were produced by the phase inversion temperature method and finally converted into a gel for topical application. Read More

Drug Dev Ind Pharm 2019 Feb 6:1-9. Epub 2019 Feb 6.

a Department of Pharmaceutics , Poona College of Pharmacy, Bharati Vidyapeeth Deemed University , Pune , India.

Chrysin (CH), a phytoconstituent has numerous pharmacological activities including anticancer activity. However, CH suffers from a drawback of poor aqueous solubility and in turn poor bioavailability limiting its clinical utility. In this work CH loaded folate-conjugated pluronic PF127-pluronic F68 mixed micelles were prepared with an objective to augment oral bioavailability and cytotoxicity of CH in human breast cancer cell line MCF-7 by active targeting mechanism. Read More

Drug Dev Ind Pharm 2019 Feb 6:1-25. Epub 2019 Feb 6.

a Division of Pharmaceutical Technology, Department of Chemistry , University of Hamburg , Hamburg , Germany.

Objective: The purpose of this study was to compare the influence of two different paddle wheel geometries on the distribution behavior of a model powder within the filling chamber of the modified feed frame of a rotary tablet press. Moreover, both paddle wheels were compared regarding their influence on the resulting tablet mass during the tableting process.

Significance: Insights are provided regarding the influence of the paddle wheel geometry on the powder distribution to optimize the die filling process. Read More

Drug Dev Ind Pharm 2019 Feb 5:1-8. Epub 2019 Feb 5.

a Department of Pharmaceutics, B.K. Mody Government Pharmacy College , Rajkot , Gujarat , India.

The aim of the present investigation was to improve the compressibility and flow property of cefuroxime axetil by co-processing it with mannitol and chitosan chlorhydrate using spray drying method. 3 full factorial design, having inlet air temperature and mannitol: chitosan chlorhydrate ratio as independent variables was used for the optimization. Statistical analysis of obtained results revealed that both independent variables had significant effect on response variables (p value < . Read More

Drug Dev Ind Pharm 2019 Feb 4:1-7. Epub 2019 Feb 4.

a Drug Product Science and Technology, Bristol-Myers Squibb Company , New Brunswick , NJ, USA.

BMS-830216 is a diprotic acid prodrug of two pK values (<2 and 6.8) with high apparent solubility at pH ≥ 7. At ∼ pH 4 solutions of BMS-830216 appear to be surface active, in which their surface tension can be reduced from 72 to 65 dynes when its concentrations is above the critical aggregation concentration (CAC∼0. Read More

Drug Dev Ind Pharm 2019 Feb 4:1-24. Epub 2019 Feb 4.

a University of Health Sciences, Gulhane Faculty of Pharmacy, Department of Pharmaceutical Technology , 06018 , Etlik , Ankara , Turkey.

Dihydroergotamine mesylate (DHE), ergotamine derivative, has been offered for clinical use to stop or treat symptoms of an emerging migraine as injection for more than a half century. It is shown that bioavailability of DHE greatly changes between the subjects and up to 99% of the orally absorbed dose may be cleared by first pass metabolism. The aim of this study was to design and optimize DHE fast-dissolving sublingual films for migraine treatment. Read More

Drug Dev Ind Pharm 2019 Feb 4:1-18. Epub 2019 Feb 4.

a Department of Pharmaceutical Technology , AU College of Pharmaceutical Sciences, Andhra University , Visakhapatnam , India.

Aim of the present study was to design vesicular gels of etodolac loaded liposomes and ethosomes for effective transdermal delivery. The physicochemical properties of vesicular gels were compared with 45% v/v ethanolic etodolac solution and commercial product (PROXYM®). The liposomes were prepared by film hydration technique whereas ethosomes were prepared by cold method respectively. Read More

Drug Dev Ind Pharm 2019 Feb 4:1-26. Epub 2019 Feb 4.

a Department of Pharmacodynamics , College of Pharmacy, University of Florida , Gainesville , Florida.

Acetylcholinesterase (AChE) inhibitors and positive allosteric nicotinic acetylcholine receptor (nAChR) modulators are potential pharmacotherapies for nicotine dependence. Because some smoking cessation aids (e.g. Read More

Drug Dev Ind Pharm 2019 Feb 1:1-9. Epub 2019 Feb 1.

a Department of Pharmaceutical Sciences, College of Pharmacy , University of South Florida , Tampa , FL , USA.

Objective: Polymeric nanoparticles (NPs) containing doxorubicin (DOX) were prepared for the inhibition of hypoxia-induced factor 1α (HIF-1α).

Significance: HIF-1α is responsible for the upregulation of several angiogenic factors, including vascular endothelial growth factor (VEGF). DOX inhibits HIF-1α but is highly toxic. Read More

Drug Dev Ind Pharm 2019 Jan 31:1-13. Epub 2019 Jan 31.

a Department of Pharmaceutics , STES's Sinhgad Institute of Pharmacy (Affiliated to Savitribai Phule Pune University) , Narhe, Pune , India.

Background: Multiple sclerosis (MS) is one of the most severe autoimmune disorder of the central nervous system (CNS).

Objective: The present research work was aimed to formulate and investigate teriflunomide (TFM)-loaded intranasal (i.n. Read More

Drug Dev Ind Pharm 2019 Jan 30:1-14. Epub 2019 Jan 30.

a Department of Pharmaceutics and Pharmaceutical Technology , Institute of Pharmacy, Nirma University , Ahmedabad, Gujarat , India.

Objective: Gentamicin sulfate (GS)-loaded poly lactic-co-glycolic acid (PLGA) polymeric nanoparticles (PNPs) were developed and incorporated in film for the treatment of surgical site infection (SSI).

Method: PNPs were prepared by double emulsification solvent removal technique using ethyl acetate solution containing PLGA and polyvinyl alcohol (PVA) as an emulsifier. The emulsion was re-emulsified using Gum Kondagogu (GKK). Read More

Drug Dev Ind Pharm 2019 Jan 25:1-29. Epub 2019 Jan 25.

a Department of Pharmaceutics , School of Pharmacy, Centre for Nano Drug/Gene Delivery and Tissue Engineering, Jiangsu University , Zhenjiang 212013 , People's Republic of China.

Isoliquiritigenin (ISL) possesses a variety of pharmacological activities amid poor solubility in water which has restricted its clinical application. In this study, Isoliquiritigenin-loaded F127/P123 polymeric micelles (ISL-FPM) were successfully prepared and evaluated in vitro and in vivo. The particle size, polydispersity index and zeta potential of the selected formulation were 20. Read More

Drug Dev Ind Pharm 2019 Jan 24:1-43. Epub 2019 Jan 24.

a Drug Development and Analysis Laboratory , School of Pharmaceutical Sciences, Siksha O Anusandhan Deemed to be University , Bhubaneswar , Odisha , India.

Objective The study was aimed to improve the dissolution and bioavailability of developed stable amorphous solid dispersions (SDs) of pioglitazone hydrochloride (PGH), a poorly water-soluble drug. Significance Poor aqueous solubility of PGH was overcome by design of SDs. Level A correlation demonstrated between in vitro release and bioavailability of PGH, suggest its biowaiver potential. Read More

Drug Dev Ind Pharm 2019 Jan 23:1-18. Epub 2019 Jan 23.

b Faculty of Oral and Dental Medicine, Department of Microbiology of Supplementary General Science , Future University in Egypt , Egypt.

Hydrogels forming in-situ have gained great attention in the area of bone tissue engineering recently, they were also showed to be a good and less invasive alternative to surgically applied ones. The primal focus of this study was to prepare chitosan-glycerol phosphate thermosensitive hydrogel formed in-situ and loaded with risedronate (bone resorption inhibitor) in an easy way with no requirement of complicated processes or large number of equipment. Then we investigated its effectiveness for bone regeneration. Read More

Drug Dev Ind Pharm 2019 Jan 19:1-10. Epub 2019 Jan 19.

b Department of Pharmaceutics , Sree Vidyanikethan College of Pharmacy , Tirupati , India.

The present study was aimed to develop Annona muricata fruit extract loaded solid lipid nanoparticles (SLNs) and explore its cytotoxic potential in vitro model of breast cancers. Extract loaded SLNs were successfully prepared by high-pressure homogenization followed by ultrasonication method and optimized using 2 full factorial design. The extract loaded SLNs were characterized using different parameters such as particle size (PS), % entrapment efficiency (EE), zeta potential (ZP) and % cumulative drug release (CDR). Read More

Drug Dev Ind Pharm 2019 Jan 19:1-32. Epub 2019 Jan 19.

a College of Pharmacy, Tanta University , Tanta , Egypt.

Objectives: Enhance the dissolution rate of bicalutamide via co-crystallization with sucralose (sweetener), with the aim to develop rapidly disintegrating tablets with subsequent prompt dissolution.

Significance: Bicalutamide is antiandrogenic agent for treatment of prostate cancer but has low and variable oral bioavailability, mainly attributed to poor dissolution. Co-crystallization with benign excipients is promising for dissolution enhancement with the additive serving dual functions. Read More

Drug Dev Ind Pharm 2019 Jan 25:1-12. Epub 2019 Jan 25.

a Division of Molecular Pharmaceutics and Drug Delivery, College of Pharmacy, The University of Texas at Austin , Austin , TX , USA.

KinetiSol is a high-shear, fusion-based technology capable of producing stable amorphous solid dispersions (ASDs) without the assistance of solvent. KinetiSol has proven successful with multiple challenging BCS class II and IV drugs, where drug properties like thermal instability or lack of appreciable solubility in volatile solvents make hot melt extrusion or spray drying unfeasible. However, there is a necessity to characterize the ASDs like those made by the KinetiSol process, in order to better understand whether KinetiSol is capable of homogeneously dispersing drug throughout a carrier in a short (<40 s) processing time. Read More

Drug Dev Ind Pharm 2019 Jan 17:1-9. Epub 2019 Jan 17.

a Eye Hospital, Wenzhou Medical University , Wenzhou , China.

Objective: This study was aimed to develop sustained drug release from levofloxacin (LF)-loaded chitosan (CS) microspheres for treating ophthalmic infections.

Significance: Dual cross-linked CS microspheres developed by the spray-drying technique displays significantly higher level of sustained drug release compared with non-cross-linked CS microspheres.

Methods: LF-loaded CS microspheres were prepared using the spray-drying technique, and then solidified with tripolyphosphate and glutaraldehyde as dual cross-linking agents. Read More

Drug Dev Ind Pharm 2019 Jan 16:1-5. Epub 2019 Jan 16.

a Department of Pharmaceutical Chemistry , Bharati Vidyapeeth (Deemed to be) University, Poona College of Pharmacy Erandwane , Pune , Maharashtra , India.

Piperine has been widely used as a bioenhancer. Simvastatin belongs to a group of medicines known as statins. It acts by inhibiting HMG CoA reductase and acts primarily as a hypolipidemic agent. Read More

Drug Dev Ind Pharm 2019 Jan 15:1-9. Epub 2019 Jan 15.

a Graduate Program in Pharmaceutical Sciences, Faculty of Pharmacy, Universidade Federal do Rio Grande do Sul (UFRGS) , Porto Alegre , Brazil.

Objective: To develop an azelaic acid (AzA)-loaded nanoemulsion with hyaluronic acid (HA) as a double targeting strategy to increase drug retention and tyrosinase inhibition activity.

Significance: Dermic melasma is a recalcitrant disease. Therefore, the development of new technologies that allow a deeper penetration in the skin while enhancing the efficacy of a safe and well-known dermatological active, like AzA, is a very promising alternative to improve the treatment of this disease. Read More

Drug Dev Ind Pharm 2019 Jan 14:1-13. Epub 2019 Jan 14.

c Faculty of Pharmacy , Bahauddin Zakariya University , Multan , Pakistan.

Current research work was conducted to synthesize Thiol modified arabinoxylan and its application in fabrication of hydrogel. Thioglycolic acid was esterified with arabinoxylan to prepare Thiolatedarabinoxylan. Appearance of peak at 2533. Read More

Drug Dev Ind Pharm 2019 Jan 14:1-9. Epub 2019 Jan 14.

a Department of Pharmaceutical Nanotechnology, School of Pharmacy , Zanjan University of Medical Sciences , Zanjan , Iran.

Objective: Indinavir (IDV), an antiretroviral protease inhibitor used in treatment of HIV infection, has limited entry into brain due to efflux by the P-glycoprotein presented in blood-brain barrier. The aim of present study was to develop lactoferrin-treated nanoemulsion containing indinavir (Lf-IDV-NEs) for delivery to brain.

Methods: Indinavir-loaded nanoemulsions (IDV-NEs) were prepared by high-speed homogenization method, and then lactoferrin was coupled to IDV-NEs by water soluble EDC method. Read More

Drug Dev Ind Pharm 2019 Jan 14:1-13. Epub 2019 Jan 14.

a Faculty of Pharmacy, Department of Pharmaceutics and Industrial Pharmacy , Al-Azhar University (Girls) , Cairo , Egypt.

Objective: The main objective of this research is to formulate, optimize, and evaluate raft-forming chewable tablets of Nizatidine. Various raft-forming agents were used in preliminary screening. Sodium alginate showed maximum raft strength, so tablets were prepared using sodium alginate as the raft forming agent, along with calcium carbonate (CaCO) as antacid and raft strengthening agent, and sodium bicarbonate (NaHCO) as a gas generating agent. Read More

Drug Dev Ind Pharm 2019 Jan 11:1-8. Epub 2019 Jan 11.

f Targeted Drug Delivery Research Center , Pharmaceutical Technology Institute, Mashhad University of Medical Sciences , Mashhad , Iran.

To explore the effect of combination therapy of epirubicin (Epi) and melittin (Mel) to cancer cells, calcium carbonate nanoparticles (CCN), as carriers, were developed which were modified with MUC1-Dimer aptamers as targeting agents. Both Epi and Mel were delivered at the same time to cancer cells overexpressing the target of MUC1 aptamer, mucin 1 glycoproteins (MCF7 and C26 cells). CCN were prepared with a water-in-oil emulsion method. Read More

Drug Dev Ind Pharm 2019 Jan 11:1-14. Epub 2019 Jan 11.

a Department of Pharmaceutics, Faculty of Pharmacy , IFTM University , Moradabad , Uttar Pradesh , India.

Objective: Innovation in material science has made it possible to fabricate a pharmaceutical material of modifiable characteristics and utility, in delivering therapeutics at a sustained/controlled rate. The objective of this study is to design and optimize the controlled release transdermal films of S-Amlodipine besylate by intercalating hydrophilic and hydrophobic polymers.

Methods: 3(2) factorial design and response surface methodology was utilized to prepare formulations by intercalating the varied concentration of polymers(A) and penetration enhancer(B) in solvent. Read More

Drug Dev Ind Pharm 2019 Jan 11:1-13. Epub 2019 Jan 11.

a Department of Pharmacy , Quaid.i.Azam University , Islamabad , Pakistan.

Objective: Difference of pH that exists between the skin surface and blood circulation can be exploited for transdermal delivery of drug molecules by loading drug into pH-sensitive polymer. Eudragit S100 (ES100), a pH-sensitive polymer having dissolution profile above pH 7.4, is used in oral, ocular, vaginal and topical delivery of drug molecules. Read More

Drug Dev Ind Pharm 2019 Jan 11:1-6. Epub 2019 Jan 11.

a a Departament of Química Orgánica , Instituto de Química, Universidad Nacional Autónoma de México , Ciudad de México , Mexico.

A possible way of improving the activity and selectivity profile of antitumor agents is to design drug carrier systems employing soluble macromolecules. Thus, four resorcinarene-PAMAM-dendrimer conjugates of chlorambucil with different groups in the lower part of the macrocycle and different length dendritic arms showed a good stability of the chemical link between drug and spacer. Evaluation of the cytotoxicity of the resorcinarene-PAMAM-dendrimer-chlorambucil conjugate employing a sulforhodamine B (SRB) assay in K-562 (human chronic myelogenous leukemia cells) demonstrated that the conjugate was more potent as an antiproliferative agent than chlorambucil. Read More

Drug Dev Ind Pharm 2019 Jan 11:1-16. Epub 2019 Jan 11.

a Department of Pharmaceutical Quality Assurance , Center for Excellence in Drug Delivery, The Maharaja Sayajirao University of Baroda , Vadodara , Gujarat , India.

In the present work, MCM-41 and MCM-48 type of nanoparticles were successfully engineered. Effect of nanosize and amine functionalization on drug release, in vitro intestinal absorption and in vivo pharmacokinetic behavior was investigated in a comprehensive manner. The tailor-made bare and surface decorated MCM-41 and MCM-48 were synthesized and evaluated for their mesoporous skeleton, pore size, particle size, surface area, zeta potential, etc. Read More

Drug Dev Ind Pharm 2019 Jan 11:1-5. Epub 2019 Jan 11.

a Department of Pharmacy , The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University , Wenzhou , PR China.

We investigated the effect of azole antifungal drugs (ketoconazole, voriconazole, and itraconazole) on the pharmacokinetics of apatinib in rats. The rats in ketoconazole, voriconazole, and itraconazole groups received single-dose apatinib 30 mg/kg after the oral administration of ketoconazole, voriconazole, and itraconazole, respectively. Co-administration of ketoconazole or voriconazole significantly increased the apatinib C and AUC and decreased the clearance. Read More

Drug Dev Ind Pharm 2019 Jan 11:1-9. Epub 2019 Jan 11.

a Nanomedicine Laboratory , School of Pharmaceutical Education and Research , Jamia Hamdard , New Delhi , India.

Despite the ongoing extensive research, cancer therapeutics still remains an area with unmet needs which is hampered by shortfall in the development of newer medicines. The present study discusses a nano-based combinational approach for treating solid tumor. Dual-loaded nanoparticles encapsulating gemcitabine HCl (GM) and simvastatin (SV) were fabricated by double emulsion solvent evaporation method and optimized. Read More

Drug Dev Ind Pharm 2019 Jan 11:1-8. Epub 2019 Jan 11.

a Faculty of Pharmaceutical Sciences , Chulalongkorn University , Pathumwan , Bangkok , Thailand.

Amphotericin B (AmB) is one of the most effective systemic antifungal agents, but its use is circumscribed by the dose-limiting toxicity of the conventional micellar dispersion formulation, Fungizone. Significantly lesser toxicity is obtained when AmB incorporated into the aqueous dispersion of lipid nanoparticles. The aim of this study was to develop and characterize AmB loaded solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs). Read More

Drug Dev Ind Pharm 2019 Jan 9:1-12. Epub 2019 Jan 9.

a Department of Pharmaceutical Technology , AU College of Pharmaceutical Sciences, Andhra University , Visakhapatnam , India.

Self-emulsifying drug delivery systems (SES) were developed to improve oral bioavailability of asenapine maleate (ASM), an antipsychotic drug with challenging amphiphobic nature and extensive pre-systemic metabolism. ASM-SES was prepared by choosing the proportion of oil, surfactant, co-surfactant from constructed phase diagram. The in vitro and ex vivo evaluation was done. Read More

Drug Dev Ind Pharm 2019 Jan 4:1-30. Epub 2019 Jan 4.

a Chemical Engineering R&D , Rahway , NJ 07065 , USA.

Direct compression offers a simple route to generate pharmaceutical dosage units and is core to the growing arena of continuous manufacturing. However, direct compression can be untenable for some active materials. This paper will outline three specific challenges API's can present to direct (active pharmaceutical ingredients) compression. Read More

Drug Dev Ind Pharm 2019 Jan 1:1-11. Epub 2019 Jan 1.

b TIFAC Centre of Relevance and Excellence in New Drug Delivery Systems, G.H. Patel Pharmacy Building, Pharmacy Department , The Maharaja Sayajirao University of Baroda , Vadodara , India.

Purpose: To prepare 7-epidocetaxel (7ED) and 10-oxo-7-epidocetaxel (10-O-7ED) formulations as like marketed Taxotere® (TXT) injection and to screen them for in vitro and in vivo anticancer efficacy including their in vivo toxicity behavior.

Methods: The 7ED and 10-O-7ED formulations were screened for in vitro anti-proliferative, anti-metastatic and cell cycle arresting behaviors. Further, in vivo acute toxicity of TXT injection containing 10% of 7ED and 10-O-7ED separately and the therapeutic study of 10-O-7ED alone were studied in B16F10 experimental metastasis mouse model. Read More

Drug Dev Ind Pharm 2018 Dec 24:1-16. Epub 2018 Dec 24.

a Department of pharmaceutical quality assurance , Centre for excellence in drug delivery, G.H. Patel pharmacy building, The Maharaja Sayajirao University of Baroda , Vadodara , India.

It is a challenge to deliver therapeutics exclusively to cancer cells, while sparing the normal cells. However, pH-sensitive delivery systems have proved to be highly efficient in fulfilling this task due to their ability to provide on-demand and selective release of drug at acidic tumor sites. As a proof of concept, here pH responsive drug delivery system based on mesoporous core shell nanoparticles (NPs) surrounded with poly acrylic acid (PAA) layers were prepared employing a facile synthesis strategy. Read More

Drug Dev Ind Pharm 2018 Dec 21. Epub 2018 Dec 21.

a Faculty of Pharmacy Beirut Arab University, Pharmaceutical Technology Department, Beirut, Lebanon , Beirut , Lebanon.

Pravastatin is a promising drug utilized in the treatment of hyperlipidemia, yet, its main clinical limitation is due to gastric liability which fractions its oral bioavailability to less than 18%. The purpose of the current study is to encapsulate pravastatin into Eudragit®-based spray-dried microparticles aspiring to overcome its acid liability. With the aim to optimize the microparticles, formulation and process parameters were studied through acid resistance challenging test. Read More

Drug Dev Ind Pharm 2018 Dec 21:1-6. Epub 2018 Dec 21.

c Department for Management of Science and Technology Development , Ton Duc Thang University , Ho Chi Minh City , Vietnam.

The objective of this study was to achieve an optimal formulation of hydrophilic-hydrophobic conjugates for nano-sized solid dispersions (SDs) with enhanced dissolution of multiple drugs in different gastrointestinal (GI) tract environments. A new conjugate powder with an optimized process was used to fabricate SDs that contained three poorly water-soluble drugs that were also poorly soluble in different dissolution media. The self-assembled nanoparticle formation, drug crystallinity and SD molecular interactions were investigated by measuring the particle size during dissolution testing and physicochemical property analysis (powder X-ray diffraction and Fourier transform infrared spectroscopy). Read More

Drug Dev Ind Pharm 2018 Dec 21. Epub 2018 Dec 21.

a Tianjin International Joint Academy of Biomedicine , No.220 Dongting Road, the Tianjin Economic-Technological Development Area (TEDA) , Tianjin , China (PRC) .

Background: Hand-Foot-Mouth Disease may cause severe central nervous system complications and even death, that induced mainly by enterovirus 71 (EV71), which is a non-enveloped virus. Inactivation of the EV71on hands could effectively inhibit the transmission. However, the inactivations of the EV71by conventional disinfectants including the alcohols are poor, due to the high stability of the EV71. Read More

Drug Dev Ind Pharm 2018 Dec 20:1-8. Epub 2018 Dec 20.

a Department of Medical Technology, Faculty of Associated Medical Sciences , Chiang Mai University , Chiang Mai , Thailand.

Curcumin, a major active compound in the turmeric rhizome, has many biological properties, especially anti-leukemia activity. The overexpression of FMS-like tyrosine kinase 3 protein with internal tandem duplication (FLT3-ITD) mutation protein was related to the poor prognosis and disease progression of leukemia. In this study, the cytotoxicity and inhibitory effect of curcumin on cell cycle of FLT3-ITD overexpressing MV4-11 leukemic cells were evaluated. Read More

Drug Dev Ind Pharm 2018 Dec 18:1-24. Epub 2018 Dec 18.

a School of pharmacy, Guangdong Pharmaceutical University , Guangzhou , China.

The purpose of this study was to prepare a novel cryptotanshinone loaded nanoemulsion (Cry LN) and to evaluate its prevention effect on the postoperative peritoneal adhesions (PPA). The Cry LN was prepared by high pressure homogenization method, and various methods were used to investigate the physicochemical properties. The results showed that Cry LN has nanoscale particle size with uniform distribution and could slowly release the incorporated drug compared with Cry solution. Read More

Drug Dev Ind Pharm 2018 Dec 17:1-40. Epub 2018 Dec 17.

a H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences , Karachi University , Karachi , 74200 , Pakistan.

Emergence of multidrug resistance (MDR) has limited the success of chemotherapeutic agents. Reversal of drugs efflux systems through combination therapy has got wider attention for increasing anticancer drugs efficacy. This study aims at co-encapsulation of Paclitaxel with Naringin in mixed polymeric micelles for enhanced anticancer activity of the drug. Read More

Drug Dev Ind Pharm 2018 Dec 4:1-29. Epub 2018 Dec 4.

a Department of Chinese Medicine , Guangdong Pharmaceutical University of China , Guangzhou , Guangdong , China.

The aim of this study was to investigate the efficacy of anti-VEGF antibody-modified Paeonol liposome gels (PAE-BEV-lip gels) in the prevention and treatment of Hypertrophic Scars (HSs). Systematic optimization of the encapsulation process of anti-VEGF antibody-modified Paeonol liposomes (PAE-BEV-lips) was performed using Box-Behnken design with the optimized parameters as follows: SPC concentration of 7.36 mg·mL; SPC-Chol-PAE:pNP-PEG-DOPE:BVE-PEG-DOPE ratio of 14:5:4:0. Read More