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Drug Dev Ind Pharm 2019 Apr 17:1-27. Epub 2019 Apr 17.

b Department of Pharmaceutics , College of Pharmacy, King Saud University , P.O. Box: 2457 , Riyadh 11451 , Saudi Arabia.

Gemfibrozil (GEM) is cholesterol-lowering agent which is being proposed as poorly water soluble drug (PWSD). Temperature based solubility values of GEM are not yet available in literature or any pharmacopoeia/monograph. Hence, the present studies were carried out to determine the solubility of PWSD GEM (as mole fraction) in various pharmaceutically used solvents such as "water (HO), methanol (MeOH), ethanol (EtOH), isopropanol (IPA), 1-butanol (1-BuOH), 2-butanol (2-BuOH), ethylene glycol (EG), propylene glycol (PG), polyethylene glycol-400 (PEG-400), ethyl acetate (EA), dimethyl sulfoxide (DMSO) and Transcutol® (THP)" at the temperatures ranging from "T = 298. Read More

Drug Dev Ind Pharm 2019 Apr 17:1-17. Epub 2019 Apr 17.

b Department of medical records management , the Second Affiliated Hospital of Mudanjiang Medical University , Mudanjiang , Heilongjiang , 157000 , P.R. China.

Purpose: Studies have determined that UNBS5162, recognized as a new naphthalimide, holds inhibitory effects in prostate and breast tumors, however its functional implication on gastric carcinoma is currently undetermined. Based on this, this study designed to assess the functional role of it on human gastric carcinoma and underlying mechanism of action.

Methods: Cell Counting Kit-8 (CCK-8) assay, transwell assay, and flow cytometry were used to assess capabilities of SGC-7901 cell proliferation, invasion/migration, and apoptosis, respectively. Read More

Drug Dev Ind Pharm 2019 Apr 16:1-42. Epub 2019 Apr 16.

a Department of Pharmaceutics , School of Pharmacy, Center for Nano Drug/Gene Delivery and Tissue Engineering, Jiangsu University , Zhenjiang 212013 , People's Republic of China.

The prevalence of hyperuricemia is relatively high worldwide, and a great number of patients are suffering from its complications. 6-shogaol, an alkylphenol compound purified from the root of ginger (Zingiber officinale Roscoe), has been proved to possess the diverse pharmacological activities. However, its poor aqueous solubility usually lead to low bioavailability, and further clinical applications will be greatly discounted. Read More

Drug Dev Ind Pharm 2019 Apr 16:1-34. Epub 2019 Apr 16.

a School of Pharmacy, University of Otago , Dunedin 9054 , New Zealand.

The purpose of this study was to investigate the influence of storage humidity on in vitro aerosolization and physicochemical properties of co-spray dried powders of kanamycin with rifampicin. The powders were stored for one-month in an open Petri dish at different relative humidities (RHs) (15%, 43% and 75%) and 25 ± 2 °C. The in vitro aerosolization (fine particle fraction, FPF) of the powders was determined by a next generation impactor (NGI). Read More

Drug Dev Ind Pharm 2019 Apr 16:1-35. Epub 2019 Apr 16.

a Centre for Biomedical Research, University of Algarve , 8005-139 , Faro , Portugal.

The direct delivery of antibiotics to the lung has been considered an effective approach to treat pulmonary tuberculosis, which represents approximately 80% of total cases. In this sense, this work aimed at producing inhalable chitosan microparticles simultaneously associating isoniazid and rifabutin, for an application in pulmonary tuberculosis therapy. Spray-dried chitosan microparticles were obtained with adequate flow properties for deep lung delivery (aerodynamic diameter of 4 µm) and high drug association efficiencies (93% for isoniazid and 99% for rifabutin). Read More

Drug Dev Ind Pharm 2019 Apr 15:1-6. Epub 2019 Apr 15.

a Department of Pharmaceutics, College of Pharmacy , King Saud University , Riyadh , Saudi Arabia.

The purpose of this work is to develop novel lipid-based self-nanoemulsifying drug delivery systems (SNEDDS) as carriers for transdermal delivery of curcumin. SNEDDS containing black seed oil, medium chain mono- and diglycerides and surfactants, were prepared as curcumin delivery vehicles. Their formation spontaneity, morphology, droplet size, and drug loading were evaluated. Read More

Drug Dev Ind Pharm 2019 Apr 15:1-40. Epub 2019 Apr 15.

a Department of Pharmaceutical Technology, Faculty of Pharmacy , Ege University , Izmir , Turkey.

Olmesartan Medoxomil (OM) is a hydrophobic antihypertensive drug with low bioavailability (26%) and is known to have adverse effects such as celiac disease and enteropathy. The purpose of this study was to develop SMEDDS to increase bioavailability and decrease potential side effects of OM. Hydrophilic lipophilic balance was calculated by testing solubility of OM in different oils, surfactants and cosurfactants to obtain the most suitable combination of SMEDDS. Read More

Drug Dev Ind Pharm 2019 Apr 13:1-34. Epub 2019 Apr 13.

a Department of Pharmaceutics , R. C. Patel Institute of Pharmaceutical Education and Research Shirpur , Dhule , Maharashtra 425405 , India.

Budesonide is BCS class II drug had low water solubility (0.045 mg/mL) and low oral bioavailability (6-8%) due to high first pass effect. It is aimed to prepare cross linked chitosan-dextran sulfate nanoparticles and/or nanodispersion. Read More

Drug Dev Ind Pharm 2019 Apr 5:1-8. Epub 2019 Apr 5.

a Institute of Pharmaceutics, College of Pharmaceutical Sciences , Zhejiang University , Hangzhou , Zhejiang , PR China.

Pearl powder has been used to treat many diseases like palpitations, insomnia, and epilepsy for thousands of years in Chinese medicine. It has demonstrated antioxidant, antiaging, antiradiative, and tonic activities. Pearl powder contains multiple active proteins, which are nutritious for skin cells and might be advantageous for wound repair and regeneration. Read More

Drug Dev Ind Pharm 2019 Apr 3:1-25. Epub 2019 Apr 3.

d Key Laboratory of Chinese Medicine Resource and Compound Prescription , Ministry of Education, Hubei University of Chinese Medicine , Wuhan , People's Republic of China.

Objective: The objective of this study was to enhance the solubility and bioavailability of Lupeol.

Methods: Utilizing a thin-film dispersion method, we prepared Lupeol-loaded PEGylated liposomes and Lupeol-loaded liposomes, which was characterized by SEM, mean diameter, PDI, zeta potential and entrapment efficiency(EE). The EE, in vitro release and stability of Lupeol-loaded PEGylated liposomes, were detected by HPLC. Read More

Drug Dev Ind Pharm 2019 Apr 2:1-47. Epub 2019 Apr 2.

b Department of Pharmacology , Government College of Pharmacy , Aurangabad , Maharashtra , India.

The solubility of itraconazole (ITRA) in thirteen pure solvents including water, dimethyl sulphoxide, acetonitrile, methanol, 1,4-butanediol, ethanol, isopropyl alcohol, n-butanol, octanol, ethyl acetate, toluene, benzene, 1,4-dioxane were estimated at the temperatures ranging from 293.15 K to 318.15 K under atmospheric pressure (0. Read More

Drug Dev Ind Pharm 2019 Apr 1:1-38. Epub 2019 Apr 1.

a Department of Pharmaceutics , School of Pharmaceutical Education and Research, Jamia Hamdard , New Delhi - 110 062 , India.

The aim of this investigation is the management of rheumatoid arthritis (RA) by developing methotrexate loaded calcium phosphate nanoparticles (MTX-CAP-NP) and to evaluate pharmacokinetic and pharmacodynamic behaviour in adjuvant induced arthritis model. The nanoparticles were synthesized by wet precipitation method and optimized by Box-Behnken experimental design. MTX-CAP-NPs were characterized by TEM, FTIR, DSC and XRD studies. Read More

Drug Dev Ind Pharm 2019 Apr 1:1-9. Epub 2019 Apr 1.

c Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy , University of Alexandria , Alexandria , Egypt.

This study describes a simple, sensitive, specific and generic HPLC-DAD method for simultaneous determination of four drugs prescribed for treatment of Hepatitis C Virus (HCV) infection. Investigated drugs include daclatasvir (DAC), ledipasvir (LED), sofosbuvir (SOF) and ribavirin (RIB). Successful separation was accomplished using Thermohypersil BDS-C8 column (4. Read More

Drug Dev Ind Pharm 2019 Mar 28:1-12. Epub 2019 Mar 28.

a Department of Pharmaceutics, JSS College of Pharmacy , Ootacamund, JSS Academy of Higher Education and Research , Mysuru , India.

Growing evidence suggest that Alzheimer's disease (AD), the most common cause of dementia among the elderly is a metabolic disorder associated with impaired brain insulin signaling. Hence, the diabetic drug can be a therapeutic option for the management AD. The researches in this area are ongoing and Pioglitazone (PIO) is one of the most investigated diabetic drug in AD. Read More

Drug Dev Ind Pharm 2019 Mar 28:1-12. Epub 2019 Mar 28.

a Guangdong Provincial Engineering & Technology Research Center for Topical Precise Drug Delivery System, School of Pharmacy , Guangdong Pharmaceutical University , Guangzhou , China.

Purpose: A series of β-CD amphiphilic star-shaped copolymers with exceptional characteristics were synthesized and their potential as carriers for micelles drug delivery was investigated.

Methods: A series of amphiphilic copolymers based on β-CD were synthesized by introducing poly (acrylic acid)-co-poly(methyl methacrylate)-poly (vinyl pyrrolidone) or poly (acrylic acid)-co-poly(methyl methacrylate)-co-poly(monoacylated-β-CD)-poly (vinyl pyrrolidone) blocks to the primary hydroxyl group positions of β-CD. The micellization behavior of the copolymers, the synthesis conditions, characteristics, drug release in vitro and tissue distribution of vinpocetine (VP) micelles in vivo were investigated. Read More

Drug Dev Ind Pharm 2019 Mar 28:1-38. Epub 2019 Mar 28.

b Department of pharmaceutics, Faculty of Pharmacy , MTI University , Egypt.

Objective: Novel niosomal formulation may be successfully applied to treat a systemic disease such as migraine through transdermal drug delivery system (TDDS), moreover, the treatment of tropical diseases such as mycotic infections by targeting and localizing the drug to the stratum corneum. The current study aims to formulate zolmitriptan (Zt) in niosomal vesicles to potentiate its transdermal effect.

Significance: The development of a promising niosomal formulation will push the scaling up of pharmaceutical industry in this field. Read More

Drug Dev Ind Pharm 2019 Mar 26:1-12. Epub 2019 Mar 26.

a Drug Delivery Research Laboratory, Department of Pharmaceutical Sciences , Dr. H. S. Gour University (A Central University) , Sagar , India.

The goal of present study to assess the antigen specific immunopotentiation effect of mannose functionalized endosomolytic and conventional nanocomposite(s) based combination approach using C57BL/6 mice melanoma model. Endosomolytic and conventional nanocomposite(s) were prepared by double emulsification method. The optimized formulation was extensively characterized for average particle size, zeta potential and PDI of nanocomposite(s) which were measured in range of ≈200 nm, 0. Read More

Drug Dev Ind Pharm 2019 Mar 26:1-9. Epub 2019 Mar 26.

a Pharmaceutics Department, School of Pharmacy , Institut Teknologi Bandung , Bandung , Indonesia.

The waste of inedible parts of pineapple, particularly in tropical countries, contributes to environmental burden. This study aimed to utilize pineapple stem waste as a source of starch-based pharmaceutical excipient. The starch was isolated from pineapple stem waste using a simple process without applying harsh chemicals. Read More

Drug Dev Ind Pharm 2019 Mar 26:1-29. Epub 2019 Mar 26.

b Department of Pharmaceutics, Faculty of Pharmacy , Alexandria University , Alexandria , Egypt.

The objective of this study was to improve candesartan cilexetil (CC) efficacy by formulating nanocrystals via solid dispersion (SD) technique using tromethamine (Tris). SDs was prepared by solvent evaporation at different drug carrier ratios, evaluated for particle size, vitro dissolution studies, TEM, FT-IR and X-ray powder diffraction. Ex vivo, In vivo pharmacokinetic parameters were conducted on selected formulae compared to drug suspension and marketed product. Read More

Drug Dev Ind Pharm 2019 Mar 25:1-10. Epub 2019 Mar 25.

a School of Pharmacy , Anhui University of Chinese Medicine , Hefei , Anhui , China.

The objective of this study was to design and evaluate azilsartan osmotic pump tablets. Preformulation properties of azilsartan were investigated for formulation design. Azilsartan osmotic pump tablets were prepared by incorporation of drug in the core and subsequent coating with cellulose acetate and polyethylene glycol 4000 as semi-permeable membrane, then drilled an orifice at the center of one side. Read More

Drug Dev Ind Pharm 2019 Mar 25:1-10. Epub 2019 Mar 25.

a Vertex Pharmaceuticals Inc , Boston , MA , USA.

The purpose of this research was to develop a fiber optic (FO) dissolution method for quantification of multiple actives in combination pharmaceutical tablets. FO dissolution allows direct API quantification in the vessel, obviating the need for error-prone facets of traditional dissolution methods. However, FO dissolution is potentially challenged by overlapping UV spectra, matrix effects, UV-active excipients, API interactions with excipients and media, and undissolved components attenuating the UV signal. Read More

Drug Dev Ind Pharm 2019 Mar 20:1-4. Epub 2019 Mar 20.

b State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute of Pharmacology and Toxicology , Beijing , China.

Novel fatty acid-bile acid conjugates (1a-1k) were designed and synthesized by coupling of the fatty acids to the 3-OH of bile acids using lysine for linkage. In the conjugates, the 24-COOH of the bile acids was kept intact to preserve liver-specific recognition. The ability of the newly synthesized conjugates (at 100 mg/kg dosage) to reduce total cholesterol (TC) and triglyceride (TG) levels in mice fed with high-fat diet (HFD) was evaluated. Read More

Drug Dev Ind Pharm 2019 Mar 19:1-10. Epub 2019 Mar 19.

a College of Pharmacy , Seoul National University , Seoul , Republic of Korea.

In the present study, in order to improve the solubility and bioavailability of poorly water-soluble dexibuprofen, a novel dexibuprofen-loaded solid dispersion was developed using the spray-drying technique. The controlled-release dexibuprofen formulation was developed by combining the immediate-release dispersion powder and the sustained-release formula. The solid dispersion composed of dexibuprofen/poloxamer 407/hydroxypropyl methylcellulose (HPMC) 2910 (50 cps)/sodium lauryl sulfate (SLS) (10/1/4/0. Read More

Drug Dev Ind Pharm 2019 Mar 18:1-30. Epub 2019 Mar 18.

a Department of Pharmaceutics, Faculty of Pharmacy , King Abdulaziz University , Jeddah , Saudi Arabia.

Objective: Control the release and enhance the bioavailability of chitosan-doxazosin mesylate nanoparticles (DM-NPs).

Significance: Improve DM bioavailability for the treatment of benign prostatic hyperplasia and hypertension.

Methods: Plackett-Burman design was utilized to screen the variables affecting the quality of DM-NPs prepared by ionic gelation method. Read More

Drug Dev Ind Pharm 2019 Mar 18:1-10. Epub 2019 Mar 18.

a Department of Physical Chemistry, Faculty of Pharmacy , Collegium Medicum of Bydgoszcz, Nicolaus Copernicus University in Toruń , Bydgoszcz , Poland.

Objective: The aim of this study was to explore the possibility of using natural deep eutectic solvents (NADES) as solvation media for enhancement of solubility of sulfonamides, as well as gaining some thermodynamic characteristics of the analyzed systems.

Significance: Low solubility of many active pharmaceutical ingredients is a well-recognized difficulty in pharmaceutical industry, hence the need for different strategies addressing this problem. Among such strategies, those that are environmentally and economically beneficial are of particular interest. Read More

Drug Dev Ind Pharm 2019 Mar 17:1-40. Epub 2019 Mar 17.

a Drug Delivery Research Laboratory , TIFAC Center of Relevance and Excellence in NDDS , Shri G. H. Patel Pharmacy Building, Donor's Plaza , Faculty of Pharmacy , The M. S. University of Baroda , Fatehgunj , Vadodara 390002 , Gujarat , India.

Objective: The aim of the present investigation was to investigate the efficacy of solid lipid nanoparticles (SLNs) to enhance the absorption and bioavailability of lurasidone hydrochloride (LH) following oral administration.

Methods: The LH loaded SLNs (LH-SLNs) were prepared by high pressure homogenization (HPH) method, optimized using box behnken design and evaluated for particle size (PS), entrapment efficiency (EE), morphology, FTIR, DSC, XRD, in vitro release, ex vivo permeation, transport studies across Caco-2 cell line and in vivo pharmacokinetic and pharmacodynamic studies.

Results: The LH-SLNs had PS of 139. Read More

Drug Dev Ind Pharm 2019 Mar 13:1-14. Epub 2019 Mar 13.

d Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy , Misr University for Science and Technology , 6th of October , Egypt.

A nanoparticulate system; cubosomes has been suggested to support the controlled release of Telmisartan (TEL), a poorly water-soluble medication. Four distinctive formulae were selected according to the results of three estimated responses. The liquid cubosomes were successfully adsorbed onto Aerosil 380 to form granules. Read More

Drug Dev Ind Pharm 2019 Mar;45(3)

Drug Dev Ind Pharm 2019 Feb 20:1-13. Epub 2019 Feb 20.

a Department of Pharmaceutics , ROFEL, Shri G. M. Bilakhia College of Pharmacy , Vapi , India.

Bicalutamide (BCT), an anticancer drug, suffers from dissolution rate limited bioavailability and poor micromeritic properties. Spherical crystallization involves the formation of spherical agglomerates with enhanced dissolution properties, obviating the need for further granulation process. The present investigation was focused on spherical agglomeration of BCT by quasi-emulsion solvent diffusion method. Read More

Drug Dev Ind Pharm 2019 Feb 15:1-13. Epub 2019 Feb 15.

a School of Natural Product Studies, Department of Pharmaceutical Technology , Jadavpur University , Kolkata , India.

Objective: To prepare and characterize an optimized phospholipid complex of Ursolic acid (UA) to overcome the poor pharmacokinetic properties and to investigate the impact of the complex on hepatoprotective activity and bioavailability in animal model.

Significance: UA is a potential phytoconstituent obtained from several plant sources, which has been explored for its diverse pharmacological activities including hepatoprotection. Its major limitation is poor absorption, rapid elimination, and hence low bioavailability after administration. Read More

Drug Dev Ind Pharm 2019 Feb 15:1-13. Epub 2019 Feb 15.

a School of Biomedical Sciences, Faculty of medicine, The University of Queensland , St Lucia , Australia.

Pulmonary infections are the most common cause of death globally. However, the development of mucosal vaccines that provide protective immunity against respiratory pathogens are limited. In contrast to needle-based vaccines, efficient vaccines that are delivered via noninvasive mucosal routes (such as via the lungs and nasal passage) produce both antigen-specific local mucosal IgA and systemic IgG protective antibodies. Read More

Drug Dev Ind Pharm 2019 Feb 15:1-9. Epub 2019 Feb 15.

a School of Pharmacy , Shenyang Pharmaceutical University , Shenyang , China.

In this work, aspirin (ASP) sustained granules were prepared using micro-crystal coating and hot-melt granulation, respectively. In the process of micro-crystal coating, PVP was used to form the isolation layer and then coated with either Eudragit RS/RL30D or ethyl cellulose (EC) as sustained-release layers to prepare sustained granules (the granules from this method were denoted m-cG). And in the process of hot-melt granulation, the granules were obtained with stearyl alcohol as a binder and EC as matrix material to prepare sustained granules (the granules were denoted h-mG). Read More

Drug Dev Ind Pharm 2019 Feb 15:1-13. Epub 2019 Feb 15.

a Shobhaben Pratapbhai Patel School of Pharmacy and Technology Management , SVKM's NMIMS , Mumbai , India.

Among lipid-based nanocarriers, multi-layered cochleates emerge as a novel delivery system because of prevention of oxidation of hydrophobic and hydrophilic drugs, enhancement in permeability, and reduction in dose of drugs. It also improves oral bioavailability and increases the safety of a drug by targeting at a specific site with less side effects. Nanostructured cochleates are used as a carrier for the delivery of water-insoluble or hydrophobic drugs of anticancer, antiviral and anti-inflammatory action. Read More

Drug Dev Ind Pharm 2019 May 14;45(5):826-838. Epub 2019 Feb 14.

a Department of Pharmaceutics , National Institute of Pharmaceutical Education & Research (NIPER) , Hyderabad , India ;

Objective: The aim of this study was to formulate nanostructured lipid carriers (NLCs) of dithranol-loaded in gel for ease of application and to evaluate its anti-psoriatic efficacy vis-a-vis conventional ointment formulation.

Significance: This study will provide an insight about the use of nanocarriers, esp. NLCs loaded with dithranol for the effective treatment of psoriasis. Read More

Drug Dev Ind Pharm 2019 Feb 11:1-9. Epub 2019 Feb 11.

a Guangdong Key Laboratory of New Dosage Forms of Drugs , Guangdong Pharmaceutical University , Guangzhou , China.

The aim of this study was to determine the effect of varying excipient content on the formation and physical properties of 3 D printed tablets. Fifteen different excipient preparations were formed into tablets with radii of 5 mm and thickness of 2 mm, using binder jetting (BJ). The tablets were analyzed by assessing visual and microstructural appearance, friability, hardness, and disintegration time. Read More

Drug Dev Ind Pharm 2019 Feb 12:1-15. Epub 2019 Feb 12.

c Department of surgical pathology , Faculty of Medicine, Cairo University , Cairo , Egypt.

Objectives: This study was aimed to develop dual-purpose natamycin (NAT)-loaded niosomes in ketorolac tromethamine (KT) gels topical ocular drug delivery system to improve the clinical efficacy of natamycin through enhancing its penetration through corneal tissue and reducing inflammation associated with Fungal keratitis (FK).

Significance: Nanosized carrier systems, as niosomes would provide great potential for improving NAT ocular bioavailability.NAT niosomal dispersion formulae were prepared and then incorporated in 0. Read More

Drug Dev Ind Pharm 2019 Feb 27:1-9. Epub 2019 Feb 27.

a Pharmaceutical Technology Unit, National Institute of Laser Enhanced Sciences (NILES) , Cairo University , Cairo , Egypt.

This study introduces a simple method for one-step synthesis of highly stable nontoxic polymer-coated gold nanospheres for use in drug delivery, focuses on the ability of chloroauric acid (HAu ) to induce polyphenols polymerization, puts up an easy procedure for loading hydrophobic drugs onto gold nanoparticles with ultra-high loading efficiency and studies the cytotoxicity of free and gold nanoparticles-loaded resveratrol. Gold nanospheres were synthesized simply by direct reaction between resveratrol itself and HAu in aqueous medium. Synthesized gold nanospheres exhibited high stability in both aqueous and ethanolic solutions. Read More

Drug Dev Ind Pharm 2019 Feb 6:1-30. Epub 2019 Feb 6.

a Department of Pharmaceutics , Bombay College of Pharmacy , Mumbai , India.

The objective of the present investigation was to improve the skin deposition and retention of metronidazole (MTZ) in rosacea therapy, by incorporating it into nanostructured lipid carriers (NLCs). The main challenge in this endeavour was the partial hydrophilicity of MTZ, which mandated careful selection of excipients, including solid and liquid lipids, surfactants, and their ratios in combination. NLCs were produced by the phase inversion temperature method and finally converted into a gel for topical application. Read More

Drug Dev Ind Pharm 2019 May 14;45(5):852-860. Epub 2019 Feb 14.

a Department of Pharmaceutics , Poona College of Pharmacy, Bharati Vidyapeeth Deemed University , Pune , India.

Chrysin (CH), a phytoconstituent has numerous pharmacological activities including anticancer activity. However, CH suffers from a drawback of poor aqueous solubility and in turn poor bioavailability limiting its clinical utility. In this work CH loaded folate-conjugated pluronic PF127-pluronic F68 mixed micelles were prepared with an objective to augment oral bioavailability and cytotoxicity of CH in human breast cancer cell line MCF-7 by active targeting mechanism. Read More

Drug Dev Ind Pharm 2019 Feb 6:1-25. Epub 2019 Feb 6.

a Division of Pharmaceutical Technology, Department of Chemistry , University of Hamburg , Hamburg , Germany.

Objective: The purpose of this study was to compare the influence of two different paddle wheel geometries on the distribution behavior of a model powder within the filling chamber of the modified feed frame of a rotary tablet press. Moreover, both paddle wheels were compared regarding their influence on the resulting tablet mass during the tableting process.

Significance: Insights are provided regarding the influence of the paddle wheel geometry on the powder distribution to optimize the die filling process. Read More

Drug Dev Ind Pharm 2019 May 5;45(5):767-774. Epub 2019 Feb 5.

a Department of Pharmaceutics, B.K. Mody Government Pharmacy College , Rajkot , Gujarat , India.

The aim of the present investigation was to improve the compressibility and flow property of cefuroxime axetil by co-processing it with mannitol and chitosan chlorhydrate using spray drying method. 3 full factorial design, having inlet air temperature and mannitol: chitosan chlorhydrate ratio as independent variables was used for the optimization. Statistical analysis of obtained results revealed that both independent variables had significant effect on response variables (p value < . Read More

Drug Dev Ind Pharm 2019 May 13;45(5):819-825. Epub 2019 Feb 13.

a Drug Product Science and Technology, Bristol-Myers Squibb Company , New Brunswick , NJ, USA.

BMS-830216 is a diprotic acid prodrug of two pK values (<2 and 6.8) with high apparent solubility at pH ≥ 7. At ∼ pH 4 solutions of BMS-830216 appear to be surface active, in which their surface tension can be reduced from 72 to 65 dynes when its concentrations is above the critical aggregation concentration (CAC∼0. Read More

Drug Dev Ind Pharm 2019 Feb 4:1-8. Epub 2019 Feb 4.

a Gulhane Faculty of Pharmacy, Department of Pharmaceutical Technology , University of Health Sciences , Ankara , Turkey.

Dihydroergotamine mesylate (DHE), ergotamine derivative, has been offered for clinical use to stop or treat symptoms of an emerging migraine as injection for more than a half century. It is shown that bioavailability of DHE greatly changes between the subjects and up to 99% of the orally absorbed dose may be cleared by first pass metabolism. The aim of this study was to design and optimize DHE fast-dissolving sublingual films for migraine treatment. Read More

Drug Dev Ind Pharm 2019 Apr 4;45(4):611-628. Epub 2019 Feb 4.

a Department of Pharmaceutical Technology , AU College of Pharmaceutical Sciences, Andhra University , Visakhapatnam , India.

Aim of the present study was to design vesicular gels of etodolac loaded liposomes and ethosomes for effective transdermal delivery. The physicochemical properties of vesicular gels were compared with 45% v/v ethanolic etodolac solution and commercial product (PROXYM®). The liposomes were prepared by film hydration technique whereas ethosomes were prepared by cold method respectively. Read More

Drug Dev Ind Pharm 2019 May 22;45(5):861-867. Epub 2019 Feb 22.

a Department of Pharmacodynamics , College of Pharmacy, University of Florida , Gainesville , FL , USA.

Acetylcholinesterase (AChE) inhibitors and positive allosteric nicotinic acetylcholine receptor (nAChR) modulators are potential pharmacotherapies for nicotine dependence. Because some smoking cessation aids (e.g. Read More

Drug Dev Ind Pharm 2019 May 12;45(5):715-723. Epub 2019 Feb 12.

a Department of Pharmaceutical Sciences, College of Pharmacy , University of South Florida , Tampa , FL , USA.

Objective: Polymeric nanoparticles (NPs) containing doxorubicin (DOX) were prepared for the inhibition of hypoxia-induced factor 1α (HIF-1α).

Significance: HIF-1α is responsible for the upregulation of several angiogenic factors, including vascular endothelial growth factor (VEGF). DOX inhibits HIF-1α but is highly toxic. Read More

Drug Dev Ind Pharm 2019 May 12;45(5):839-851. Epub 2019 Feb 12.

a Department of Pharmaceutics , STES's Sinhgad Institute of Pharmacy (Affiliated to Savitribai Phule Pune University) , Narhe, Pune , India.

Background: Multiple sclerosis (MS) is one of the most severe autoimmune disorder of the central nervous system (CNS).

Objective: The present research work was aimed to formulate and investigate teriflunomide (TFM)-loaded intranasal (i.n. Read More

Drug Dev Ind Pharm 2019 May 14;45(5):805-818. Epub 2019 Feb 14.

a Department of Pharmaceutics and Pharmaceutical Technology , Institute of Pharmacy, Nirma University , Ahmedabad, Gujarat , India.

Objective: Gentamicin sulfate (GS)-loaded poly lactic-co-glycolic acid (PLGA) polymeric nanoparticles (PNPs) were developed and incorporated in film for the treatment of surgical site infection (SSI).

Method: PNPs were prepared by double emulsification solvent removal technique using ethyl acetate solution containing PLGA and polyvinyl alcohol (PVA) as an emulsifier. The emulsion was re-emulsified using Gum Kondagogu (GKK). Read More

Drug Dev Ind Pharm 2019 Jan 25:1-29. Epub 2019 Jan 25.

a Department of Pharmaceutics , School of Pharmacy, Centre for Nano Drug/Gene Delivery and Tissue Engineering, Jiangsu University , Zhenjiang 212013 , People's Republic of China.

Isoliquiritigenin (ISL) possesses a variety of pharmacological activities amid poor solubility in water which has restricted its clinical application. In this study, Isoliquiritigenin-loaded F127/P123 polymeric micelles (ISL-FPM) were successfully prepared and evaluated in vitro and in vivo. The particle size, polydispersity index and zeta potential of the selected formulation were 20. Read More

Drug Dev Ind Pharm 2019 May 16;45(5):775-786. Epub 2019 Feb 16.

a Drug Development and Analysis Laboratory , School of Pharmaceutical Sciences, Siksha O Anusandhan Deemed to be University , Bhubaneswar , India.

Objective: The study was aimed to improve the dissolution and bioavailability of developed stable amorphous solid dispersions (SDs) of pioglitazone hydrochloride (PGH), a poorly water-soluble drug.

Significance: Poor aqueous solubility of PGH was overcome by the design of SDs. Level A correlation demonstrated between in vitro release and bioavailability of PGH, suggest its biowaiver potential. Read More