5,437,866 results match your criteria Drug Design Development and Therapy [Journal]

  • Page 1 of 108758

[Correlation among serum levels of Irisin, insulin resistance and abdominal obesityin patients with first-episode schizophrenia].

Zhonghua Yi Xue Za Zhi 2019 Feb;99(7):520-524

Department of Psychiatry, First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, China.

To explore the possible role of Irisin in antipsychotic drug-induced insulin resistance and abdominal obesity in patients with schizophrenia and to provide a theoretical basis for the prevention of antipsychotic drug-induced obesity. Fifty-five patients with first-episode schizophrenia, from the First Affiliated Hospital of Zhengzhou University, between January 2016 and December 2017, were admitted as well as fifty healthy controls during the same period. Serum Irisin levels were measured by enzyme-linked immunosorbent assay (ELISA). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3760/cma.j.issn.0376-2491.2019.07.009DOI Listing
February 2019

Effectiveness of Insulin Analogs Compared with Human Insulins in Pregnant Women with Diabetes Mellitus: Systematic Review and Meta-analysis.

Rev Bras Ginecol Obstet 2019 Feb 20;41(2):104-115. Epub 2019 Feb 20.

Universidade Federal de Alagoas, Maceió, AL, Brazil.

Diabetes during pregnancy has been linked to unfavorable maternal-fetal outcomes. Human insulins are the first drug of choice because of the proven safety in their use. However, there are still questions about the use of insulin analogs during pregnancy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1055/s-0038-1676510DOI Listing
February 2019

Using Electronic Health Records to Identify Adverse Drug Events in Ambulatory Care: A Systematic Review.

Appl Clin Inform 2019 Jan 20;10(1):123-128. Epub 2019 Feb 20.

Department of Global Biostatistics and Data Science, Tulane University School of Public Health and Tropical Medicine, Tulane University, New Orleans, Louisiana, United States.

Objective:  We identified the methods used and determined the roles of electronic health records (EHRs) in detecting and assessing adverse drug events (ADEs) in the ambulatory setting.

Methods:  We performed a systematic literature review by searching PubMed and Google Scholar for studies on ADEs detected in the ambulatory setting involving any EHR use published before June 2017. We extracted study characteristics from included studies related to ADE detection methods for analysis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1055/s-0039-1677738DOI Listing
January 2019

Cholinergic drugs ameliorate endothelial dysfunction by decreasing O-GlcNAcylation via M3 AChR-AMPK-ER stress signaling.

Life Sci 2019 Feb 17. Epub 2019 Feb 17.

Department of Pharmacology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi 710061, People's Republic of China. Electronic address:

Aims: Obesity is associated with increased cardiovascular morbidity and mortality. It is accompanied by augmented O-linked β-N-acetylglucosamine (O-GlcNAc) modification of proteins via increasing hexosamine biosynthetic pathway (HBP) flux. However, the changes and regulation of the O-GlcNAc levels induced by obesity are unclear. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.lfs.2019.02.036DOI Listing
February 2019

History of Psychopharmacology.

Annu Rev Clin Psychol 2019 Feb 20. Epub 2019 Feb 20.

Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, University of California, Los Angeles, California 90095-1759, USA; email:

We live in an age of psychopharmacology. One in six persons currently takes a psychotropic drug. These drugs have profoundly shaped our scientific and cultural understanding of psychiatric disease. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1146/annurev-clinpsy-050718-095514DOI Listing
February 2019

Kinetics of Drug Binding and Residence Time.

Annu Rev Phys Chem 2019 Feb 20. Epub 2019 Feb 20.

Department of Pharmacy and Biotechnology, University of Bologna, I-40126 Bologna, Italy; email:

The kinetics of drug binding and unbinding is assuming an increasingly crucial role in the long, costly process of bringing a new medicine to patients. For example, the time a drug spends in contact with its biological target is known as residence time (the inverse of the kinetic constant of the drug-target unbinding, 1/ k). Recent reports suggest that residence time could predict drug efficacy in vivo, perhaps even more effectively than conventional thermodynamic parameters (free energy, enthalpy, entropy). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1146/annurev-physchem-042018-052340DOI Listing
February 2019

Needed: Antimicrobial Development.

N Engl J Med 2019 Feb;380(8):783-785

From the Food and Drug Administration, Silver Spring, MD (E.C., S.N.).

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1056/NEJMe1901525DOI Listing
February 2019

Sacituzumab Govitecan-hziy in Refractory Metastatic Triple-Negative Breast Cancer.

N Engl J Med 2019 Feb;380(8):741-751

From the Massachusetts General Hospital Cancer Center (A.B., S.J.I.) and Dana-Farber Cancer Institute (S.M.T.), Harvard Medical School, Boston; Vanderbilt-Ingram Cancer Center, Nashville (I.A.M., V.G.A.); Weill Cornell Medical College (L.T.V.) and New York-Presbyterian-Columbia University Irving Medical Center (K.K.), New York; University of Colorado Cancer Center, Aurora (J.R.D.); Texas Oncology, Baylor University Medical Center, US Oncology, Dallas (J.O.); Orlando Health University of Florida Health Cancer Center, Orlando (R.L.M., N.C.S.); Yale University School of Medicine, New Haven, CT (A.D.S.); University of California, San Francisco, Helen Diller Family Comprehensive Cancer Center, San Francisco (H.S.R.); Immunomedics, Morris Plains, NJ (D.M.G., R.I., S.W., R.M.S., W.A.W.); and AIS Consulting, Ann Arbor, MI (A.M.S.).

Background: Standard chemotherapy is associated with low response rates and short progression-free survival among patients with pretreated metastatic triple-negative breast cancer. Sacituzumab govitecan-hziy is an antibody-drug conjugate that combines a humanized monoclonal antibody, which targets the human trophoblast cell-surface antigen 2 (Trop-2), with SN-38, which is conjugated to the antibody by a cleavable linker. Sacituzumab govitecan-hziy enables delivery of high concentrations of SN-38 to tumors. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1056/NEJMoa1814213DOI Listing
February 2019

Design of CK2β-mimicking peptides as tools to study the CK2α/CK2β interaction in cancer cells.

ChemMedChem 2019 Feb 20. Epub 2019 Feb 20.

University of Cologne, Department of Pharmacology, Gleueler Strasse 24, 50931, Cologne, GERMANY.

The ubiquitously expressed Ser/Thr kinase CK2 is a key regulator in a variety of key processes in normal and malignant cells. Due to its distinctive anti-apoptotic and tumor-driving properties, elevated levels of CK2 have frequently been found in tumors of different origin. In recent years, development of CK2 inhibitors has largely been focused on ATP-competitive compounds; however, targeting the CK2α/CK2β interface has emerged as a further concept that might avoid selectivity issues. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cmdc.201800786DOI Listing
February 2019

Drug Discovery for Pemphigoid Diseases.

Curr Protoc Pharmacol 2019 Feb 20:e55. Epub 2019 Feb 20.

Lübeck Institute of Experimental Dermatology, University of Lübeck, Lübeck, Germany.

Pemphigoid diseases (PDs) are a group of autoimmune bullous diseases characterized and caused by autoantibodies targeting structural proteins of the skin and mucous membranes. Chronic inflammation, subepidermal blistering, and often scaring are the clinical characteristics of PDs. Itching and, in severe cases, disabilities resulting from scaring (i. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cpph.55DOI Listing
February 2019

A Phase 3, Randomized, Placebo-Controlled Evaluation of the Safety of Intravenous Meloxicam Following Major Surgery.

Clin Pharmacol Drug Dev 2019 Feb 20. Epub 2019 Feb 20.

Tampa General Hospital, Tampa, FL, USA.

An intravenous (IV) formulation of meloxicam is being studied for moderate to severe pain management. This phase 3, randomized, multicenter, double-blind, placebo-controlled trial evaluated the safety of once-daily meloxicam IV 30 mg in subjects following major elective surgery. Eligible subjects were randomized (3:1) to receive meloxicam IV 30 mg or placebo administered once daily. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cpdd.666DOI Listing
February 2019

Adhesive Hemostatic Conducting Injectable Composite Hydrogels with Sustained Drug Release and Photothermal Antibacterial Activity to Promote Full-Thickness Skin Regeneration During Wound Healing.

Small 2019 Feb 20:e1900046. Epub 2019 Feb 20.

Frontier Institute of Science and Technology, and State Key Laboratory for Mechanical Behavior of Materials, Xi'an Jiaotong University, Xi'an, 710049, China.

Developing injectable nanocomposite conductive hydrogel dressings with multifunctions including adhesiveness, antibacterial, and radical scavenging ability and good mechanical property to enhance full-thickness skin wound regeneration is highly desirable in clinical application. Herein, a series of adhesive hemostatic antioxidant conductive photothermal antibacterial hydrogels based on hyaluronic acid-graft-dopamine and reduced graphene oxide (rGO) using a H O /HPR (horseradish peroxidase) system are prepared for wound dressing. These hydrogels exhibit high swelling, degradability, tunable rheological property, and similar or superior mechanical properties to human skin. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/smll.201900046DOI Listing
February 2019

Concurrent Proteomic Fingerprinting and Molecular Analysis Of Cyathostomins.

Proteomics 2019 Feb 20:e1800290. Epub 2019 Feb 20.

Institute for Parasitology and Tropical Veterinary Medicine, Department of Veterinary Medicine, Freie Universität Berlin, Germany.

Rapid, cost-effective, efficient and reliable helminth species identification is of considerable importance to understand host-parasite interactions, clinical disease and drug resistance. Cyathostomins (Nematoda: Strongylidae) are considered to be the most important equine parasites, yet research on this group has been hampered by the large number of 50 morphologically differentiated species, their occurrence in mixed infections with up to 15 species and the difficulties associated with conventional identification methods. Here, MALDI-TOF MS, previously successfully applied to identify numerous organisms, was evaluated and compared with conventional and molecular genetic approaches. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/pmic.201800290DOI Listing
February 2019

Creating Cell and Animal Models of Human Disease by Genome Editing Using CRISPR/Cas9.

J Gene Med 2019 Feb 20:e3082. Epub 2019 Feb 20.

Department of Genetics, Shiraz University of Medical Science, Shiraz, Iran.

Aims: Set of unique sequences in bacterial genomes, responsible for protecting bacteria against bacteriophages, have been recently used for genetic manipulation of specific points in the genome. These system comprises of one RNA component and one enzyme component, known as CRISPR and Cas9, respectively. The present review focuses on the applications of the CRISPR/Cas9 technology in the development of cellular and animal models of human disease. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jgm.3082DOI Listing
February 2019

Quantifying bias reduction with fixed-duration versus all-available covariate assessment periods.

Pharmacoepidemiol Drug Saf 2019 Feb 20. Epub 2019 Feb 20.

Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.

Purpose: Implementing a cohort study in longitudinal healthcare databases requires looking back over some covariate assessment period (CAP) preceding cohort entry to measure confounders. We used simulations to compare fixed-duration versus all-available CAPs for confounder adjustment in the presence of differences in available baseline time between exposure groups.

Methods: We simulated cohorts of 10 000 patients with binary variables for a single confounder, exposure, and outcome. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/pds.4729DOI Listing
February 2019

Evaluation of X-ray tomography contrast agents: A review of production, protocols, and biological applications.

Microsc Res Tech 2019 Feb 20. Epub 2019 Feb 20.

School of Engineering, London South Bank University, London, United Kingdom.

X-ray computed tomography is a strong tool that finds many applications both in medical applications and in the investigation of biological and nonbiological samples. In the clinics, X-ray tomography is widely used for diagnostic purposes whose three-dimensional imaging in high resolution helps physicians to obtain detailed image of investigated regions. Researchers in biological sciences and engineering use X-ray tomography because it is a nondestructive method to assess the structure of their samples. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jemt.23225DOI Listing
February 2019

Coordinating Tissue Regeneration through TGF-β Activated Kinase 1 (TAK1) In-activation and Re-activation.

Stem Cells 2019 Feb 20. Epub 2019 Feb 20.

Department of Surgery, University of Michigan, Ann Arbor, Michigan.

Aberrant wound healing presents as inappropriate or insufficient tissue formation. Using a model of musculoskeletal injury, we demonstrate that loss of TGF-β activated kinase 1 (TAK1) signaling reduces inappropriate tissue formation (heterotopic ossification) through reduced cellular differentiation. Upon identifying increased proliferation with loss of TAK1 signaling, we considered a regenerative approach to address insufficient tissue production through coordinated inactivation of TAK1 to promote cellular proliferation, followed by re-activation to elicit differentiation and extracellular matrix (ECM) production. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/stem.2991DOI Listing
February 2019

Identification of a new inhibitor of KRAS-PDEδ interaction targeting KRAS mutant non-small cell lung cancer.

Int J Cancer 2019 Feb 20. Epub 2019 Feb 20.

State Key Laboratory of Quality Research in Chinese Medicine/Macau Institute For Applied Research in Medicine and Health, Macau University of Science and Technology, Avenida Wai Long, Taipa, Macau (SAR), China.

Oncogenic KRAS is considered a promising target for anti-cancer therapy. However, direct pharmacological strategies targeting KRAS-driven cancers remained unavailable. The prenyl-binding protein PDEδ, a transporter of KRAS, has been identified as a potential target for pharmacological inhibitor by selectively binding to its prenyl-binding pocket, impairing oncogenic KRAS signaling pathway. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ijc.32222DOI Listing
February 2019

Regulation of P300 and HDAC1 on endoplasmic reticulum stress in isoniazid-induced HL-7702 hepatocyte injury.

J Cell Physiol 2019 Feb 20. Epub 2019 Feb 20.

Hebei Province Key Laboratory of Occupational Health and Safety for Coal Industry, School of Public Health, North China University of Science and Technology, Tangshan, Hebei, China.

P300 and HDAC1 can be involved in the development of various liver diseases by regulating gene transcription. Endoplasmic reticulum stress (ERS) is one of the main pathways of apoptosis and is activated during inflammatory responses, but the roles of P300 and HDAC1 in ERS in antituberculosis drug-induced liver injury (ADLI) are not clear. This study confirms that isoniazid can change the states of P300 and HDAC1 in HL-7702 hepatocyte metabolism and induce ERS, causing hepatocyte injury and apoptosis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jcp.28175DOI Listing
February 2019

NK007 helps in mitigating paclitaxel resistance through p38MAPK activation and HK2 degradation in ovarian cancer.

J Cell Physiol 2019 Feb 20. Epub 2019 Feb 20.

The First Affiliated Hospital, Biomedical Translational Research Institute and School of Pharmacy, Jinan University, Guangzhou, China.

Ovarian cancer resistance to available medicines is a huge challenge in dire need of a solution, which makes its recurrence and mortality rate further exacerbated. A promising approach to overcome chemoresistance is drug screening from natural products. Here, we report that NK007, a (±)-tylophorine malate isolated from the Asclepiadaceae family, selectively inhibited the proliferation of A2780 and A2780 (Taxol) cells and migration of paclitaxel-sensitive and -resistant ovarian cancer cells. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jcp.28278DOI Listing
February 2019

Healing through Parenting: An Intervention Delivery and Process of Change Model Developed with Low-Income Latina/o Immigrant Families.

Fam Process 2019 Feb 20. Epub 2019 Feb 20.

Steve Hicks School of Social Work, The University of Texas at Austin, Austin, TX.

Low-income Latinas/os are exposed to widespread mental health disparities in the United States. Most recently, a resurgence of anti-immigration narratives has led vulnerable Latina/o immigrants to experience considerable contextual stressors with multiple deleterious consequences for their overall well-being, including significant disruptions to their parenting practices. Within this context of adversity and despite the multiple benefits associated with parent training (PT) prevention interventions, the availability of contextually and culturally relevant PT interventions remains limited in underserved Latina/o communities. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/famp.12429DOI Listing
February 2019

DNA Methylation Regulates Corneal Epithelial Wound Healing by Targeting miR-200a and CDKN2B.

Invest Ophthalmol Vis Sci 2019 Feb;60(2):650-660

School of Ophthalmology and Optometry, Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China.

Purpose: DNA methylation is a key epigenetic modification involved in various biological processes and diseases. Corneal epithelial wound healing (CEWH) is essential for restoring corneal integrity and transparency after injury. However, the role of DNA methylation in CEWH remains elusive. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1167/iovs.18-25443DOI Listing
February 2019

Introduction of the YTE mutation into the non-immunogenic HIV bnAb PGT121 induces anti-drug antibodies in macaques.

PLoS One 2019 20;14(2):e0212649. Epub 2019 Feb 20.

PlantVax Corporation, Rockville, Maryland United States of America.

Recombinant antibodies play increasingly important roles as immunotherapeutic treatments for human cancers as well as inflammatory and infectious diseases and have revolutionized their management. In addition, their therapeutic potential may be enhanced by the introduction of defined mutations in the crystallizable fragment (Fc) domains eg YTE (M252Y/S254T/T256E) and LS (M428L/N434S), as a consequence of increased half-lives and prolonged duration of protection. However, the functional properties of any biologic may be compromised by unanticipated immunogenicity in humans, rendering them ineffective. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212649PLOS
February 2019

High quality process of care increases one-year survival after acute myocardial infarction (AMI): A cohort study in Italy.

PLoS One 2019 20;14(2):e0212398. Epub 2019 Feb 20.

Department of Epidemiology of Lazio Regional Health Service, Rome, Italy.

Background: The relationship between guideline adherence and outcomes in patients with acute myocardial infarction (AMI) has been widely investigated considering the emergency, acute, post-acute phases separately, but the effectiveness of the whole care process is not known.

Aim: The study aim was to evaluate the effect of the multicomponent continuum of care on 1-year survival after AMI.

Methods: We conducted a cohort study selecting all incident cases of AMI from health information systems during 2011-2014 in the Lazio region. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212398PLOS
February 2019

Metal based donepezil analogues designed to inhibit human acetylcholinesterase for Alzheimer's disease.

PLoS One 2019 20;14(2):e0211935. Epub 2019 Feb 20.

Division of Computer-Aided Drug Design, The Red-Green Research Centre, Dhaka, Bangladesh.

Among neurodegenerative disorders, Alzheimer's disease (AD) is one of the most common disorders showing slow progressive cognitive decline. Targeting acetylcholinesterase (AChE) is one of the major strategies for AD therapeutics, as cholinergic pathways in the cerebral cortex and basal forebrain are compromised. Herein, we report the design of some copper and other metal based donepezil derivatives, employing density functional theory (DFT). Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0211935PLOS
February 2019

Ibrutinib increases the risk of hypertension and atrial fibrillation: Systematic review and meta-analysis.

PLoS One 2019 20;14(2):e0211228. Epub 2019 Feb 20.

Serviço de Cardiologia, Hospital Universitário de Santa Maria (CHLN), CAML, Centro Cardiovascular da Universidade de Lisboa-CCUL, Faculdade de Medicina, Universidade de Lisboa, Avenida Professor Egas Moniz, Lisboa, Portugal.

Introduction: Ibrutinib is an oral covalent inhibitor of Bruton's tyrosine kinase approved for the treatment of patients with chronic lymphocytic leukemia (CLL), mantle cell lymphoma and Waldenstrӧm's macroglobulinemia. Ibrutinib has an increased risk of atrial fibrillation but the mechanism is unknown, and hypertension may play a role in the pathogenesis of this adverse drug reaction.

Methods: We aimed to review the risk of hypertension and atrial fibrillation as adverse events associated with ibrutinib through a systematic review with meta-analysis of randomized controlled trials (RCTs) retrieved in December 2018 on MEDLINE, EMBASE, CENTRAL and ClinicalTrials. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0211228PLOS
February 2019
3.234 Impact Factor

Access to and price trends of antidiabetic, antihypertensive, and antilipidemic drugs in outpatient settings of the Universal Coverage Scheme in Thailand.

PLoS One 2019 20;14(2):e0211759. Epub 2019 Feb 20.

Department of Clinical Pharmacy, Faculty of Pharmacy, Mahasarakham University, Mahasarakham, Thailand.

Under the Universal Coverage Scheme (UCS) with payment per capita for outpatient (OP) services, hospitals' financial risks will rise if access to essential drugs increases. This study examined trends in access to and price of essential drugs for noncommunicable diseases (NCDs) and an overall purchasing price index (PPI) for an OP drug basket from public hospitals. To examine drug access, OP prescription data from 2010-2012 were obtained from the UCS. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0211759PLOS
February 2019

Involvement of gliadin, a component of wheat gluten, in increased intestinal permeability leading to non-steroidal anti-inflammatory drug-induced small-intestinal damage.

PLoS One 2019 20;14(2):e0211436. Epub 2019 Feb 20.

Department of Gastroenterology, Osaka City University Graduate School of Medicine, Osaka, Japan.

Gliadin, a component of wheat gluten known to be an important factor in the etiology of celiac disease, is related to several other diseases through its enhancing effect on intestinal paracellular permeability. We investigated the significance of gliadin in non-steroidal anti-inflammatory drug (NSAID)-induced small-intestinal damage in mice. 7-week-old C57BL/6 male mice were divided into the following groups: standard diet group, in which mice were fed with wheat-containing standard rodent diet (CE-2); gluten-free diet group, in which mice were fed with gluten-free diet (AIN-76A); and gliadin-administered group, in which mice fed with gluten-free diet were administered with gliadin (~250 mg/kg BW). Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0211436PLOS
February 2019

Meropenem and Amikacin for Management of Post-Neurosurgical Infections from Acinetobacter baumannii.

Surg Infect (Larchmt) 2019 Feb 20. Epub 2019 Feb 20.

Department of Critical Care Medicine, Suizhou Hospital Affiliated to Hubei Medical College, Hubei, China.

Background: Intra-cranial infection with Acinetobacter baumannii is a tough problem because of the presence of multi-resistance and poor drug penetration through the blood-brain barrier. Such intra-cranial infections can lead to serious complications and death. We retrospectively analyzed the culture results and clinical characteristics of patients with intra-cranial infections in our hospital and suggested intravenous (IV) meropenem and intra-thecal (IT) amikacin therapy may be effective in the management of A. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/sur.2018.242DOI Listing
February 2019

Impact of Farnesol as a Modulator of Efflux Pumps in a Fluconazole-Resistant Strain of Candida albicans.

Microb Drug Resist 2019 Feb 20. Epub 2019 Feb 20.

1 Department of Microbiology and Virology, Faculty of Natural Sciences, Comenius University in Bratislava, Bratislava, Slovakia.

Aim: This work studied the impact of the quorum-sensing molecule, farnesol (FAR), on fluconazole (FLC)-resistant Candida albicans isolate CY 1123 compared with the susceptible standard strain C. albicans SC5314. The genes encoding efflux pumps belonging to the ATP-binding cassette (ABC) and major facilitator superfamilies, together with overexpression or point mutation of the ERG11 gene, are the main resistance mechanisms to azole antifungal drugs. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/mdr.2017.0332DOI Listing
February 2019

Development of a Luminex xTAG Assay for the Rapid Detection of Five Aminoglycoside Resistance Genes Both in Staphylococci and Enterococci.

Microb Drug Resist 2019 Feb 20. Epub 2019 Feb 20.

1 Guangdong Laboratory Animals Monitoring Institute, Guangzhou, China.

Resistance to aminoglycoside antibiotics is now common in pathogenic bacteria, making treatment of infections difficult. The rapid spread of resistance is mainly related to the dissemination of genes encoding aminoglycoside-modifying enzymes (AMEs). Staphylococci and enterococci are opportunistic human pathogens capable of causing a wide range of infections. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/mdr.2018.0297DOI Listing
February 2019

High Rate of Serotype Switching and Genetic Variations Indicates Widespread Recombination Between Clinical and Commensal Penicillin-Nonsusceptible Streptococcus pneumoniae in Tehran.

Microb Drug Resist 2019 Feb 20. Epub 2019 Feb 20.

3 Department of Microbiology, Pasteur Institute of Iran, Tehran, Iran.

A total of 161 Streptococcus pneumoniae were collected between 2013 and 2015 in Tehran, Iran. The strains were tested for antimicrobial susceptibility and minimum inhibitory concentrations, serotyped, and genotyped by multilocus sequence typing (MLST) and pulsed-field gel electrophoresis (PFGE). Penicillin-binding proteins (PBPs) were also typed by restriction fragment length polymorphism (PBP-RFLP). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/mdr.2018.0336DOI Listing
February 2019

Robustness of the Line Probe Assay for the Rapid Diagnosis and Characterization of Mutations in Extensively Drug-Resistant Tuberculosis.

Microb Drug Resist 2019 Feb 20. Epub 2019 Feb 20.

4 Department of Microbiology, CMC Vellore, Vellore, Tamil Nadu, India.

Introduction: Extensively drug-resistant tuberculosis (XDRTB) is a public health concern. We evaluated the diagnostic accuracy of Genotype MTBDRsl for detection of resistance to fluoroquinolones (FQs) and second-line injectable drugs (SLIDs) and characterized mutations seen.

Materials And Methods: MTBDRsl was carried out either directly on sputum samples or indirectly on culture isolates (n = 100) from known multidrug-resistant tuberculosis (MDRTB) patients from July 2015 to September 2017. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/mdr.2018.0268DOI Listing
February 2019

Green Breast Milk Following Ingestion of Blue-Green Algae: A Case Report.

Breastfeed Med 2019 Feb 20. Epub 2019 Feb 20.

1 Department of Neonatology, The Helen Schneider Hospital for Women, Rabin Medical Center, Petach Tikva and Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.

Breast milk is an excellent nutritional source for newborns, and a change in its color can be alarming to both mother and physician, and may prevent breastfeeding. Different colors of breast milk have been reported such as blood-stained, blue, and bluish-green. We present the first case of green breast milk caused by maternal ingestion of blue-green algae pills immediately before and after delivery. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/bfm.2018.0184DOI Listing
February 2019

Generalized On-demand Production of Nanoparticle Monolayers on Arbitrary Solid Surfaces via Capillarity-mediated Inverse Transfer.

Nano Lett 2019 Feb 20. Epub 2019 Feb 20.

Century-old Langmuir monolayer deposition still represents the most convenient approach to the production of monolayers of colloidal nanoparticles on solid substrates for practical biological and chemical sensing applications. However, this approach simply yields arbitrarily-shaped large monolayers on a flat surface, and is strongly limited by substrate topography and interfacial energy. Here we describe a generalized and facile method of rapidly producing uniform monolayers of various colloidal nanoparticles on arbitrary solid substrates by using an ordinary capillary tube. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.nanolett.9b00248DOI Listing
February 2019

Developing and Testing of Lipid Force Fields with Applications to Modeling Cellular Membranes.

Chem Rev 2019 Feb 20. Epub 2019 Feb 20.

The amphipathic nature of the lipid molecule (hydrophilic head and hydrophobic tails) enables it to act as a barrier between fluids with various properties and to sustain an environment where the processes critical to life may proceed. While computer simulations of biomolecules primarily investigate protein conformation and binding to drug-like molecules, these interactions often occur in the context of a lipid membrane. Chemical specificity of lipid models is essential to accurately represent the complex environment of the lipid membrane. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.chemrev.8b00384DOI Listing
February 2019

Fimsbactin and Acinetobactin Compete for the Periplasmic Siderophore Binding Protein BauB in Pathogenic Acinetobacter baumannii.

ACS Chem Biol 2019 Feb 20. Epub 2019 Feb 20.

Environmental and pathogenic microbes produce siderophores as small iron-binding molecules to scavenge iron from natural environments. It is common for microbes to produce multiple siderophores to gain a competitive edge in mixed microbial environments. Strains of human pathogenic Acinetobacter baumannii produce up to three siderophores: acinetobactin, baumannoferrin, and fimsbactin. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acschembio.8b01051DOI Listing
February 2019

Mussel-inspired Self-healing Coatings Based on Polydopamine Coated Nanocontainers for Corrosion Protection.

ACS Appl Mater Interfaces 2019 Feb 20. Epub 2019 Feb 20.

Mussel-inspired properties of dopamine have attracted immense scientific interest for surface modification of nanoparticles due to the high potential of dopamine functional groups to increase adhesion of nanoparticles to flat surfaces. Here, we report for the first time a novel type of inhibitor-loaded nanocontainers using polydopamine (PDA) as a pH-sensitive gatekeeper for mesoporous silica nanoparticles (MSNs). The encapsulated inhibitor (benzotriazole) was loaded into MSNs at neutral pH, demonstrating fast release in acidic environment. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acsami.8b21197DOI Listing
February 2019

The Future of Registries in the Era of Real-world Evidence for Medical Devices.

JAMA Cardiol 2019 Feb 20. Epub 2019 Feb 20.

US Food and Drug Administration, Silver Spring, Maryland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1001/jamacardio.2018.4933DOI Listing
February 2019

Temporal and spatial distribution of American tegumentary leishmaniasis in north Paraná: 2010-2015.

Rev Soc Bras Med Trop 2019 Feb 14;52:e20180119. Epub 2019 Feb 14.

Departamento de Ciências Patológicas, Centro de Ciências Biológicas, Universidade Estadual de Londrina, Londrina, PR, Brasil.

Introduction: Describing the general aspects of American tegumentary leishmaniasis enables the identification of the epidemiological scenario of the disease and the development of preventive actions.

Methods: We analyzed the records of patients with American tegumentary leishmaniasis in north Paraná between 2010 and 2015.

Results: We identified 108 cases (mostly in 2014) with the following characteristics: male individuals, rural workers, and ages averaging 56. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1590/0037-8682-0119-2018DOI Listing
February 2019

GASTRIC FUNDIC GLAND POLYPS: CAN HISTOLOGY BE USEFUL TO PREDICT PROTON PUMP INHIBITORS USE?

Arq Gastroenterol 2018 Oct-Dec;55(4):380-384

Universidade Federal de Sergipe, Departamento de Medicina, Aracaju, SE, Brasil.

Background: Fundic gland polyps allegedly increased in frequency in recent decades, and had attracted great attention due to possible association with prolonged proton pump inhibitor therapy. Prolonged use of this drug could cause parietal cell hyperplasia, obstruction of glandular lumen and cystic dilation of the gland.

Objective: This study aims to analyze clinical and pathological features of fundic gland polyps in patients with and without proton pump inhibitor therapy in a selected population from Brazil. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1590/S0004-2803.201800000-82DOI Listing

HEPATITIS C IN THE BRAZILIAN PUBLIC HEALTH CARE SYSTEM: BURDEN OF DISEASE.

Arq Gastroenterol 2018 Oct-Dec;55(4):329-337

Universidade Federal de São Paulo, Escola Paulista de Medicina, São Paulo, SP, Brasil.

Background: Infection by hepatitis C virus is one of the leading causes of chronic hepatitis C and cause severe burden for patients, families and the health care system.

Objective: The aims of this research were to assess the severity of liver fibrosis, comorbidities and complications of hepatitis C virus; to examine health-related quality of life (HRQoL), productivity loss and resource use and costs in a sample of Brazilian chronic hepatitis C, genotype 1, patients.

Methods: This was a cross-sectional multicenter study performed in genotype-1 chronic hepatitis C patients to assess disease burden in the Brazilian public health care system between November 2014 and March 2015. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1590/S0004-2803.201800000-74DOI Listing

Risk factors associated with in-hospital falls reported to the Patient Safety Commitee of a teaching hospital.

Einstein (Sao Paulo) 2019 Feb 14;17(1):eAO4432. Epub 2019 Feb 14.

Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.

Objective: To investigate the use of fall-risk-increasing drugs among patients with falls reported to the Patient Safety Office of a hospital, and to identify the factors associated with high risk for fall.

Methods: A cross-sectional study, carried out in a teaching hospital. The study population was the universe of fall reports received by the Patient Safety Office. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.31744/einstein_journal/2019AO4432DOI Listing
February 2019

[Use of antidepressants during breastfeeding: evaluating drug package inserts conformity with science-based bibliographical sources].

Cad Saude Publica 2019 Feb 18;35(2):e00041018. Epub 2019 Feb 18.

Faculdade de Medicina, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brasil.

This article sought to evaluate the conformity between recommendations regarding antidepressant use during breastfeeding found in drug package inserts with recommendations from science-based bibliographic sources. We evaluated the standard drug package inserts of 23 antidepressants with active registration in Brazil. The presence of contraindications of antidepressant use during breastfeeding was compared with information present in the Brazilian Ministry of Health technical manual, the book Medications and Mothers' Milk and on the databases LactMed, Micromedex and UpToDate. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1590/0102-311X00041018DOI Listing
February 2019

Ruxolitinib treatment reduces monocytic superoxide radical formation without affecting hydrogen peroxide formation or systemic oxidative nucleoside damage in myelofibrosis.

Leuk Lymphoma 2019 Feb 20:1-9. Epub 2019 Feb 20.

b Institute for Inflammation Research (IIR), Center for Rheumatology and Spine Diseases, Rigshospitalet, University of Copenhagen , Copenhagen , Denmark.

The role of excess reactive oxygen species (ROS) with consequent DNA/RNA damage is now recognized as a hallmark of cancer. In JAK2V617F mutated myeloproliferative neoplasms, ROS have been suggested to be important factors in disease initiation and progression. Ruxolitinib is the most widely used drug for myelofibrosis, because it improves symptom-score. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/10428194.2019.1579323DOI Listing
February 2019

A review of dupilumab in the treatment of atopic diseases.

Hum Vaccin Immunother 2019 Feb 20. Epub 2019 Feb 20.

a Department of Dermatology , University of California, San Francisco , San Francisco.

Dupilumab is a fully human monoclonal IgG4 antibody directed against the alpha subunit of the IL-4 receptor and prevents the signaling of IL-4 and IL-13, two type 2 cytokines known to be important drivers of atopic diseases. In March of 2017, the United States Food and Drug Administration (FDA) approved dupilumab for the treatment of moderate-to-severe atopic dermatitis in adults that is uncontrolled with topical medications, becoming the first biologic agent approved to treat this chronic skin condition. In October of 2018, Dupilumab received approval by the FDA as an add-on maintenance therapy in patients with moderate-to-severe asthma aged 12 years or older with an eosinophilic phenotype or with oral corticosteroid-dependent asthma. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/21645515.2019.1582403DOI Listing
February 2019

Shrunken pore syndrome, preeclampsia, and markers of NO metabolism in pregnant women during the first trimester.

Scand J Clin Lab Invest 2019 Feb 20:1-8. Epub 2019 Feb 20.

i Kantonsspital Graubünden , Zentrallabor , Chur , Switzerland.

Shrunken pore syndrome (SPS) is a condition that manifests itself as the decreased renal clearance of low-molecular-weight proteins but normal clearance of creatinine. Pregnant women with evidence of SPS during the first trimester have an increased risk of developing preeclampsia (PE). The nitric oxide (NO) metabolism markers arginine and ADMA, especially their ratio (Arg/ADMA), are recognized markers of endothelial dysfunction. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/00365513.2019.1568150DOI Listing
February 2019

Current and emerging pharmacotherapy for the treatment of infections following open-heart surgery.

Expert Opin Pharmacother 2019 Feb 20:1-22. Epub 2019 Feb 20.

a Dipartimento di Scienze della Salute (DISSAL) , University of Genoa , Genoa , Italy.

Introduction: Patients undergoing open-heart surgery may suffer from postoperative complications, including severe infections. Antimicrobials to treat infectious complications in this population should be selected thoughtfully, taking into account three different and fundamental issues: (i) the site of infection; (ii) the suspected or proven causative agent and its susceptibility pattern; and (iii) the risk of suboptimal pharmacokinetic characteristics and potential toxicity of the chosen drug/s. Areas covered: The present narrative review summarizes the current and future antimicrobial options for the treatment of infections developing after open-heart surgery. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/14656566.2019.1574753DOI Listing
February 2019

The pharmacologic management of multiple myeloma in older adults.

Expert Opin Pharmacother 2019 Feb 20:1-16. Epub 2019 Feb 20.

d Department of Medicine, Division of Hematology and Oncology , Case Western Reserve University , Cleveland , OH , USA.

Introduction: Multiple myeloma is a disease predominately affecting older adults. Pivotal to treating older adults is understanding their physiologic differences compared to younger subjects and how the complexity of therapies has an impact upon this patient population. Areas covered: Herein, the authors address the efficacy of chemotherapy regimens, decision-making for older adults, chemotherapy-associated toxicity and the approach to management. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/14656566.2019.1577822DOI Listing
February 2019
  • Page 1 of 108758