1,702 results match your criteria Drug Delivery[Journal]


pH sensitive peptide functionalized nanoparticles for co-delivery of erlotinib and DAPT to restrict the progress of triple negative breast cancer.

Drug Deliv 2019 Dec;26(1):470-480

b Department of General Surgery , Changhai Hospital The Second Military Medical University , Shanghai , People's Republic of China.

Although a variety of drug delivery strategies have been designed for enhancing the treatment of Triple negative breast cancer (TNBC), combating with TNBCs is still dramatically challenged by the selection of appropriate therapeutic targets and insufficient tumor accumulation or inner penetration of chemotherapeutics. To address these issues, the classical EGFR-inhibitor, erlotinib (EB), was selected as the model drug here and PLA-based nano-platform (NP-EB) was prepared for tumor site drug delivery. Given the significant role of Notch-EGFR interplay in raising severe resistance to EGFR inhibition of EB, gamma secretase inhibitor (GSI)-DAPT was further entrapped into the core of nanoparticles to inhibit the activation of Notch signaling (NP-EB/DART). Read More

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http://dx.doi.org/10.1080/10717544.2019.1576801DOI Listing
December 2019

Novel ultra-small micelles based on ginsenoside Rb1: a potential nanoplatform for ocular drug delivery.

Drug Deliv 2019 Dec;26(1):481-489

a Department of Pharmacy, College of Chemical Engineering , Qingdao University of Science and Technology , Qingdao , China.

Objectives: Ginsenosides Rb1 (Rb1) could form micelles in aqueous solutions. Self-assembled Rb1 micelles could potentially be utilized as ocular drug delivery system, and it was postulated that the encapsulation of a medicine within Rb1 micelles might strengthen the drug's therapeutic action and reduce side effects.

Methods: Diclofenac-loaded Rb1 micelles (Rb1-Dic micelles) were formulated, optimized, and then further evaluated for in vitro cytotoxicity/in vivo ocular irritation, in vivo corneal permeation, and in vivo anti-inflammatory efficacy. Read More

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https://www.tandfonline.com/doi/full/10.1080/10717544.2019.1
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http://dx.doi.org/10.1080/10717544.2019.1600077DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461112PMC
December 2019
8 Reads

Transient blood-brain barrier disruption is induced by low pulsed electrical fields in vitro: an analysis of permeability and trans-endothelial electric resistivity.

Drug Deliv 2019 Dec;26(1):459-469

b The Joseph Sagol Neuroscience Center, Sheba Medical Center , Ramat Gan , Israel.

The blood-brain barrier (BBB) is limiting transcellular and paracellular movement of molecules and cells, controls molecular traffic, and keeps out toxins. However, this protective function is the major hurdle for treating brain diseases such as brain tumors, Parkinson's disease, Alzheimer's disease, etc. It was previously demonstrated that high pulsed electrical fields (PEFs) can disrupt the BBB by inducing electroporation (EP) which increases the permeability of the transcellular route. Read More

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http://dx.doi.org/10.1080/10717544.2019.1571123DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461088PMC
December 2019
1 Read

Doxorubicin-loaded red blood cells reduced cardiac toxicity and preserved anticancer activity.

Drug Deliv 2019 Dec;26(1):433-442

a Department of Bioengineering , University of California , San Diego , CA , USA.

Doxorubicin (DOX) is one of the most widely used anticancer agents. DOX is known for inducing cardiotoxicity, resulting in the long-term development of heart failure. Intravascular delivery of DOX may benefit from the carriage by red blood cells (RBCs), as they can limit the systemic toxicity while delivering the DOX to the tumor. Read More

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http://dx.doi.org/10.1080/10717544.2019.1591544DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6450495PMC
December 2019
1 Read

The involvement of perivascular spaces or tissues in the facial intradermal brain-targeted delivery.

Drug Deliv 2019 Dec;26(1):393-403

a College of Pharmaceutical Science , Zhejiang Chinese Medical University , Hangzhou , China.

Our previous work indicates the lymphatic network and perivascular spaces or tissues might be involved in the facial intradermal brain-targeted delivery of Evans blue (EB). In this article, we presented the detailed involvement of both, and the linkage between lymphatic network and perivascular spaces or tissues. The in-vivo imaging, the trigeminal transection and immunohistochemistry were used. Read More

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http://dx.doi.org/10.1080/10717544.2019.1587044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6450571PMC
December 2019
1 Read

Surface-engineered polyethyleneimine-modified liposomes as novel carrier of siRNA and chemotherapeutics for combination treatment of drug-resistant cancers.

Drug Deliv 2019 Dec;26(1):443-458

a Center for Pharmaceutical Biotechnology and Nanomedicine , Northeastern University , Boston , MA , USA.

Modification of nanoparticle surfaces with PEG has been widely considered the gold standard for many years. However, PEGylation presents controversial and serious challenges including lack of functionality, hindered cellular interaction, allergic reactions, and stimulation of IgM production after repetitive dosing that accelerates blood clearance of the nanoparticles. We report the development of novel liposomal formulations surface-modified with a low molecular weight, branched polyethyleneimine (bPEI)-lipid conjugate for use as an alternative to PEG. Read More

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http://dx.doi.org/10.1080/10717544.2019.1574935DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6450504PMC
December 2019

Application and design of esterase-responsive nanoparticles for cancer therapy.

Drug Deliv 2019 Dec;26(1):416-432

a Institute of Biomedical Materials and Engineering, College of Chemistry and Chemical Engineering, College of Materials Science and Engineering , Qingdao University , Qingdao , Shandong , P.R. China.

Nanoparticles have been developed for tumor treatment due to the enhanced permeability and retention effects. However, lack of specific cancer cells selectivity results in low delivery efficiency and undesired side effects. In that case, the stimuli-responsive nanoparticles system designed for the specific structure and physicochemical properties of tumors have attracted more and more attention of researchers. Read More

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http://dx.doi.org/10.1080/10717544.2019.1588424DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6450553PMC
December 2019
1 Read

A 3D CFD model of the interstitial fluid pressure and drug distribution in heterogeneous tumor nodules during intraperitoneal chemotherapy.

Drug Deliv 2019 Dec;26(1):404-415

a Biofluid, Tissue and Solid Mechanics for Medical Applications (bioMMeda), Department of Electronics and Information Systems , Ghent University , Ghent , Belgium.

Although intraperitoneal chemotherapy (IPC) has evolved into an established treatment modality for patients with peritoneal metastasis (PM), drug penetration into tumor nodules remains limited. Drug transport during IPC is a complex process that depends on a large number of different parameters (e.g. Read More

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http://dx.doi.org/10.1080/10717544.2019.1588423DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6450529PMC
December 2019
2 Reads

PEGylation of lipophilic SN38 prodrug with DSPE-mPEG versus cremophor EL: comparative study for intravenous chemotherapy.

Drug Deliv 2019 Dec;26(1):354-362

b School of Pharmacy , Key Laboratory of Sichuan Province for Specific Structure of Small Molecule Drugs, Chengdu Medical College , Chengdu , China.

The lipophilic prodrug of hydrophobic drugs with well-designed molecular structures can form stable pure prodrug nanoparticles (NPs), but rapid NPs aggregation in plasma greatly restricted their direct use for intravenous chemotherapy. To address this, DSPE-mPEG and Cremophor EL are two of the most widely used lipophilic PEG derivatives to enhance their colloidal stability in plasma. However, their drug delivery performances have never been comparatively studied. Read More

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http://dx.doi.org/10.1080/10717544.2019.1587045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442117PMC
December 2019
2 Reads

Transdermal metformin hydrochloride-loaded cubic phases: in silico formulation optimization, preparation, properties, and application for local treatment of melanoma.

Drug Deliv 2019 Dec;26(1):376-383

b Department of Pharmaceutical Sciences , Beijing Institute of Radiation Medicine , Beijing , China.

Metformin hydrochloride (Met) is commonly used for antidiabetic therapy though its antimelanoma action is also reported. Conventional oral administration method of Met is not appropriate for therapy of melanoma because of large dose, adverse reactions, and low efficiency. Here, a transdermal Met-loaded cubic phase was developed for local treatment of melanoma. Read More

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http://dx.doi.org/10.1080/10717544.2019.1587046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442100PMC
December 2019

A portfolio of biologic self-injection devices in rheumatology: how patient involvement in device design can improve treatment experience.

Drug Deliv 2019 Dec;26(1):384-392

f The Parker Institute , Copenhagen University Hospital , Bispebjerg and Frederiksberg , Denmark.

Biologic drugs (e.g. anti-tumor necrosis factors) are effective treatments for multiple chronic inflammatory diseases including rheumatoid arthritis, axial spondyloarthritis, and psoriatic arthritis. Read More

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http://dx.doi.org/10.1080/10717544.2019.1587043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442222PMC
December 2019
1 Read

Recent progress in LyP-1-based strategies for targeted imaging and therapy.

Drug Deliv 2019 Dec;26(1):363-375

a Department of Nuclear Medicine , Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai , People's Republic of China.

The identification of markers expressed by pathological cells or their microenvironment would help to distinguish such cells from the normal tissues. The strategies derived from this theory can be a promising modality for imaging and treating diseases. LyP-1, a tumor homing peptide, can selectively bind to its receptor p32 protein overexpressed in various tumor-associated cells and atherosclerotic plaque macrophages. Read More

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http://dx.doi.org/10.1080/10717544.2019.1587047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442157PMC
December 2019

Improving cellular uptake of therapeutic entities through interaction with components of cell membrane.

Drug Deliv 2019 Dec;26(1):328-342

c School of Life Sciences , Taishan Medical University , Tai'an , P.R. China.

Efficient cellular delivery of biologically active molecules is one of the key factors that affect the discovery and development of novel drugs. The plasma membrane is the first barrier that prevents direct translocation of chemic entities, and thus obstructs their efficient intracellular delivery. Generally, hydrophilic small molecule drugs are poor permeability that reduce bioavailability and thus limit the clinic application. Read More

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http://dx.doi.org/10.1080/10717544.2019.1582730DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442206PMC
December 2019
4 Reads

Correction.

Authors:

Drug Deliv 2019 Mar 25. Epub 2019 Mar 25.

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http://dx.doi.org/10.1080/10717544.2019.1594569DOI Listing

A biocompatible reverse thermoresponsive polymer for ocular drug delivery.

Drug Deliv 2019 Dec;26(1):343-353

b Centre for Eye Research Australia , Royal Victorian Eye and Ear Hospital, Melbourne, Australia.

Age-related macular degeneration (AMD) is a leading cause of vision loss, the treatment of which may require monthly intravitreal injections. This is a burden on patients and health services, and new delivery modalities that reduce injection frequency are required. To that end, we investigated the suitability of a novel reverse thermoresponsive polymer (RTP) as an ocular drug-delivery vehicle. Read More

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http://dx.doi.org/10.1080/10717544.2019.1587042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442223PMC
December 2019

Poly(3-hydroxybutyrate-CO-3-hydroxyvalerate) PHBHV biocompatible nanocarriers for 5-FU delivery targeting colorectal cancer.

Drug Deliv 2019 Dec;26(1):318-327

b Department of Biochemistry and Molecular Biology , University of Bucharest , Bucharest , Romania.

Aiming to address the issue of poor bioavailability of most anti-tumor medicines against colorectal cancer, we developed a targeted anticancer nanocarrier using biocarriers able to both bind and easily release their load in a controlled manner. Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) carriers were obtained via the emulsification-diffusion method, loaded with 5-fluorouracil and then characterized in terms of particle morphology and size (SEM, DLS), drug uptake and release. The cytotoxic potential of the 5-fluorouracil-loaded polymer nanocarriers on human adenocarcinoma cells (HT-29 cell line) was investigated. Read More

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http://dx.doi.org/10.1080/10717544.2019.1582729DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442118PMC
December 2019

Preparation, optimization of the inclusion complex of glaucocalyxin A with sulfobutylether-β-cyclodextrin and antitumor study.

Drug Deliv 2019 Dec;26(1):309-317

a School of Pharmacy , Nanjing Tech University , Nanjing , China.

Glaucocalyxin A (GLA), is a diterpenoid extracted from Hara and has been studied for decades for its diverse bioactivities. However, GLA presents poor solubility in water and low bioavailability through oral administration which has hindered its application in the clinic. So in this study, we prepared the inclusion complex of GLA in SBE-β-CD by ultrasound method and evaluated its antitumor effect and cytotoxic effect on cancer cells. Read More

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http://dx.doi.org/10.1080/10717544.2019.1568623DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442205PMC
December 2019

Development and effects of tacrolimus-loaded nanoparticles on the inhibition of corneal allograft rejection.

Drug Deliv 2019 Dec;26(1):290-299

a State Key Laboratory of Ophthalmology , Zhongshan Ophthalmic Center, Sun Yat-sen University , Guangzhou , China.

Tacrolimus has been widely applied to prevent organ rejection after transplantation. However, the conventional pharmaceutical formulation of tacrolimus limits its applications in ocular therapy due to its hydrophobicity and low corneal penetrability. We optimized tacrolimus-loaded methoxy poly (ethylene glycol-block-poly (d, l)-lactic-co-glycolic acid) nanoparticles (TAC-NPs) by simple and effective nanotechnology as a drug delivery system for corneal graft rejection to overcome these drawbacks. Read More

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http://dx.doi.org/10.1080/10717544.2019.1582728DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442111PMC
December 2019
3 Reads

pH and reduction dual-responsive micelles based on novel polyurethanes with detachable poly(2-ethyl-2-oxazoline) shell for controlled release of doxorubicin.

Drug Deliv 2019 Dec;26(1):300-308

a School of Chemistry & Materials Science , Jiangsu Key Laboratory of Green Synthetic Chemistry for Functional Materials, Jiangsu Normal University , Xuzhou , China.

We describe a biodegradable amphiphilic polyurethane (PU) with disulfide bonds in the main chain [PEtOz-b-PU(SS)-b-PEtOz]. This multi-block PU was synthesized using poly (ε-caprolactone) diol (PCL-SS-PCL) and poly (2-ethyl-2-oxazoline) (PEtOz-OH) as soft segments, and bis (2-isocyanatoethyl) disulfide as the hard segment. Acid-sensitive PEtOz-OH was used as a hydrophilic segment for pH sensitivity. Read More

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http://dx.doi.org/10.1080/10717544.2019.1580323DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442156PMC
December 2019
1 Read

Novel ophthalmic formulation of myriocin: implications in retinitis pigmentosa.

Drug Deliv 2019 Dec;26(1):237-243

a Department of Biomedical and Biotechnological Sciences, School of Medicine , University of Catania , Catania , Italy.

Myriocin is an antibiotic derived from Mycelia sterilia, and is a potent inhibitor of serine palmitoyltransferase, the enzyme involved in the first step of sphingosine synthesis. Myriocin, inhibiting ceramide synthesis, has a great potential for treatment of diseases characterized by high ceramide levels in affected tissues, such as retinitis pigmentosa (RP). Drug delivery to the retina is a challenging task, which is generally by-passed through intravitreal injection, that represents a risky invasive procedure. Read More

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http://dx.doi.org/10.1080/10717544.2019.1574936DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6419690PMC
December 2019

Exploitation of enrofloxacin-loaded docosanoic acid solid lipid nanoparticle suspension as oral and intramuscular sustained release formulations for pig.

Drug Deliv 2019 Dec;26(1):273-280

b National Reference Laboratory of Veterinary Drug Residues (HZAU) , Huazhong Agricultural University , Wuhan , China.

In our previous study, enrofloxacin-loaded docosanoic acid solid lipid nanoparticles (SLNs) could be effectively delivered to cells in vitro. In this study, its properties and exploitation as possible oral and intramuscular sustained release formulations for pigs were studied after being made into suspension. The re-dispersed time and sedimentation rate of the nanosuspension were 55 s and 1, respectively. Read More

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http://dx.doi.org/10.1080/10717544.2019.1580798DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6427631PMC
December 2019
1 Read

Combined using of paclitaxel and salinomycin active targeting nanostructured lipid carriers against non-small cell lung cancer and cancer stem cells.

Drug Deliv 2019 Dec;26(1):281-289

b School of Pharmacy , Qiqihar Medical University , Qiqihar , China.

The existing of avidity cancer stem cells (CSCs) made it an optical strategy to kill cancer cells and CSCs at the same time. Here, we constructed a CSCs specific nanocarrier naming T-S-NLC using the CD133+ targeting peptide TISWPPR (TR) as the targeting moiety attached to the distal end of PEG on salinomycin (Sal) loaded nanostructured lipid carriers (NLC), its pharmaceutical characteristics proved it 128.73 ± 2. Read More

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https://www.tandfonline.com/doi/full/10.1080/10717544.2019.1
Publisher Site
http://dx.doi.org/10.1080/10717544.2019.1580799DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6427498PMC
December 2019
12 Reads

Fractional laser-assisted topical delivery of bleomycin quantified by LC-MS and visualized by MALDI mass spectrometry imaging.

Drug Deliv 2019 Dec;26(1):244-251

a Department of Dermatology , Bispebjerg University Hospital , Copenhagen , Denmark.

Bleomycin exhibits antiproliferative effects desirable for use in dermato-oncology but topical use is limited by its 1415 Da molar mass. Ablative fractional laser (AFL)-assisted drug delivery has been shown to enhance drug uptake in skin. The aim of this study was with AFL to deliver bleomycin into skin, quantify uptake, and visualize biodistribution with mass spectrometry. Read More

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http://dx.doi.org/10.1080/10717544.2019.1574937DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6419659PMC
December 2019
3 Reads

Preparation and drug delivery of dextran-drug complex.

Drug Deliv 2019 Dec;26(1):252-261

a Active Carbohydrate Research Institute, Chongqing Key Laboratory of Inorganic Functional Materials , Chongqing Normal University , Chongqing , China.

Dextran as a drug carrier for inhibiting cancer cells effectively reduces the toxic and side effects of the drug in the biological body. Targeting improves the concentration of active substance around the target tissue, which reduces damage to other heavy organs and other normal tissues. Dextran will be a potential carrier for the delivery of antitumor drugs in the future, which provides the possibility of slow-release chemotherapy and targeted drug delivery. Read More

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https://www.tandfonline.com/doi/full/10.1080/10717544.2019.1
Publisher Site
http://dx.doi.org/10.1080/10717544.2019.1580322DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6419624PMC
December 2019
3 Reads

Dual-functionalized liposome by co-delivery of paclitaxel with sorafenib for synergistic antitumor efficacy and reversion of multidrug resistance.

Drug Deliv 2019 Dec;26(1):262-272

b College of Life Science, Nanjing Normal University , Nanjing , PR China.

Multidrug resistance (MDR) remains one of the major reasons for inefficiency of many chemotherapeutic agents in cancer therapy. In this study, a D-α-tocopheryl polyethylene glycol 1000 succinate (TPGS) and polylysine-deoxycholic acid copolymer (PLL-DA) co-modified cationic liposome coating with hyaluronic acid (HA) was constructed for co-delivery of paclitaxel (PTX) and chemosensitizing agent, sorafenib (SOR) to treat the MDR cancer. The multifunctional liposome (HA-TPD-CL-PTX/SOR) presented good stability against rat plasma and was capable of reversing surface zeta potential under acidic conditions in the presence of HAase. Read More

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http://dx.doi.org/10.1080/10717544.2019.1580797DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6419656PMC
December 2019
2 Reads

Intra-articular injection of triamcinolone acetonide releasing biomaterial microspheres inhibits pain and inflammation in an acute arthritis model.

Drug Deliv 2019 Dec;26(1):226-236

a Department of Orthopedics , University Medical Center Utrecht , Utrecht , the Netherlands.

Inflammation of the synovium and joint capsule is a main driver of pain in an osteoarthritic (OA) joint. Triamcinolone acetonide (TAA) is a classical corticosteroid that reduces synovitis and alleviates pain, albeit transiently. Biomaterial-based local TAA release may prolong the suppression of pain without the need for multiple injections. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407600PMC
December 2019
1 Read

Design of novel proliposome formulation for antioxidant peptide, glutathione with enhanced oral bioavailability and stability.

Drug Deliv 2019 Dec;26(1):216-225

a College of Pharmacy and Institute of Drug Research and Development , Chungnam National University , Daejeon , South Korea.

To develop proliposome formulations to improve the oral bioavailability of l-glutathione (GSH), GSH-loaded proliposomes were prepared using the granule method. Mannitol was selected as an effective excipient to achieve the desired particle size, entrapment efficiency (EE), and solubility for oral delivery of the final formulation. To evaluate the effect of surface charge of proliposomes on the oral bioavailability of GSH, negative (F1-F4) and positive proliposomes (F5-F9) were prepared. Read More

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https://www.tandfonline.com/doi/full/10.1080/10717544.2018.1
Publisher Site
http://dx.doi.org/10.1080/10717544.2018.1551441DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407602PMC
December 2019
4 Reads

A more efficient ocular delivery system of triamcinolone acetonide as eye drop to the posterior segment of the eye.

Drug Deliv 2019 Dec;26(1):188-198

a Department of Geriatrics , Qilu Hospital of Shandong University , Jinan , PR China.

As a leading cause of vision impairment of the retina, macular edema (ME) has one of the highest clinical demands for treatment. Current treatment of ME relies heavily on invasive techniques resulting in complications and poor patient compliance. To enhance the efficiency of triamcinolone acetonide as eye drop to the posterior segment of the eye, we developed and characterized a novel formulation, namely, triamcinolone acetonide chitosan-coated liposomes (TA-CHL), prepared by the calcium acetate gradient method with some modifications. Read More

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http://dx.doi.org/10.1080/10717544.2019.1571122DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407580PMC
December 2019
2 Reads

Study on preparation, characterization and multidrug resistance reversal of red blood cell membrane-camouflaged tetrandrine-loaded PLGA nanoparticles.

Drug Deliv 2019 Dec;26(1):199-207

a School of Pharmacy , Shanghai Jiao Tong University , Shanghai , China.

The multidrug resistance in tumor (MDR) is a major barrier to efficient cancer therapy. Modern pharmacological studies have proven that tetrandrine (TET) has great potential in reversing MDR. However, it has a series of medication problems in clinic such as poor water solubility, low oral bioavailability and short half-life in vivo. Read More

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http://dx.doi.org/10.1080/10717544.2019.1573861DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407593PMC
December 2019
5 Reads

The improved antitumor efficacy of continuous intratumoral chemotherapy with cisplatin-loaded implants for the treatment of sarcoma 180 tumor-bearing mice.

Drug Deliv 2019 Dec;26(1):208-215

b Department of Bone Disease and Bone Tumors Surgery , First Affiliated Hospital of Anhui Medical University , Hefei , People's Republic of China.

Cisplatin is the most commonly used antitumor drug in the chemotherapy of a variety of malignancies. However, the severe side effects and drug resistance limit its clinical application. The aim of this study was to develop PLGA-based cisplatin-loaded implants and evaluate the antitumor efficacy of continuous intratumoral chemotherapy with the implants. Read More

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http://dx.doi.org/10.1080/10717544.2019.1574938DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407574PMC
December 2019
2.202 Impact Factor

Pre-clinical assessment of a water-in-fluorocarbon emulsion for the treatment of pulmonary vascular diseases.

Drug Deliv 2019 Dec;26(1):147-157

a Cardiovascular and Pulmonary Research Laboratory, Department of Medicine , University of Colorado Denver, Anschutz Medical Campus , Aurora , CO , USA.

Hypoxic pulmonary vasoconstriction (HPV) is a well-characterized vascular response to low oxygen pressures and is involved in life-threatening conditions such as high-altitude pulmonary edema (HAPE) and pulmonary arterial hypertension (PAH). While the efficacy of oral therapies can be affected by drug metabolism, or dose-limiting systemic toxicity, inhaled treatment via pressured metered dose inhalers (pMDI) may be an effective, nontoxic, practical alternative. We hypothesized that a stable water-in-perfluorooctyl bromide (PFOB) emulsion that provides solubility in common pMDI propellants, engineered for intrapulmonary delivery of pulmonary vasodilators, reverses HPV during acute hypoxia (HX). Read More

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http://dx.doi.org/10.1080/10717544.2019.1568621DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407583PMC
December 2019

A thermosensitive gel based on w1/o/w2 multiple microemulsions for the vaginal delivery of small nucleic acid.

Drug Deliv 2019 Dec;26(1):168-178

b Division of Life Science, Key Lab in Healthy Science and Technology , Graduate School at Shenzhen, Tsinghua University , Shenzhen , China.

The present study aims at designing a thermosensitive gel prepared from w1/o/w2 multiple microemulsions (MMEs) for the vaginal delivery of siRNA. The w1/o/w2 MMEs were prepared by two-step emulsifications: the first step was to prepare primary emulsions (w1/o) by low energy emulsification (LEE); the second step was to obtain stable w1/o/w2 MMEs by self-emulsifying. An extensive formulation optimization process was undertaken. Read More

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http://dx.doi.org/10.1080/10717544.2019.1568622DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407577PMC
December 2019
2 Reads

Hydrogel containing minocycline and zinc oxide-loaded serum albumin nanopartical for periodontitis application: preparation, characterization and evaluation.

Drug Deliv 2019 Dec;26(1):179-187

d Department of pathology , Xuzhou Medical University , Xuzhou , China.

Periodontal disease is a complex problem which often interrelates with several serious systemic diseases. However, the satisfactory clinical therapy has yet to be achieved. Herein, serum albumin microspheres containing minocycline and zinc oxide nanoparticals (ZnO NPs) were prepared and incorporated in a Carbopol 940 hydrogel. Read More

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http://dx.doi.org/10.1080/10717544.2019.1571121DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407595PMC
December 2019
1 Read

Ultra-small micelles based on polyoxyl 15 hydroxystearate for ocular delivery of myricetin: optimization, in vitro, and in vivo evaluation.

Drug Deliv 2019 Dec;26(1):158-167

a Department of Pharmacy, College of Chemical Engineering , Qingdao University of Science and Technology , Qingdao , China.

The aim was to develop a nanocarrier based on polyoxyl 15 hydroxystearate (Kolliphor® HS15, HS15) micelles for the solubility, stability, and ocular delivery of myricetin (Myr). An optimized ratio of HS15 and Myr was prepared to fabricate HS15-Myr micelle ophthalmic solution. Myr-encapsulating HS15 micelles (HS15-Myr micelles) were subjected to physicochemical characterizations. Read More

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http://dx.doi.org/10.1080/10717544.2019.1568624DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407586PMC
December 2019
2.202 Impact Factor

Novel compounds protect auditory hair cells against gentamycin-induced apoptosis by maintaining the expression level of H3K4me2.

Drug Deliv 2018 Nov;25(1):1033-1043

a ENT Institute and Otorhinolaryngology Department of Affiliated Eye and ENT Hospital , Key Laboratory of Hearing Medicine of NHFPC, Shanghai Engineering Research Centre of Cochlear Implant, State Key Laboratory of Medical Neurobiology, Fudan University , Shanghai , China.

Aminoglycoside-induced hair cell (HC) loss is a major cause of hearing impairment, and the effective prevention of HC loss remains an unmet medical need. Epigenetic mechanisms have been reported to be involved in protecting cochlear cells against ototoxic drug injury, and in this study we developed new bioactive compounds that have similar chemical structures as the epigenetics-related lysine-specific demethylase 1 (LSD1) inhibitors. LSD1 inhibitors have been reported to protect cochlear cells by preventing demethylation of dimethylated histone H3K4 (H3K4me2). Read More

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http://dx.doi.org/10.1080/10717544.2018.1461277DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6058728PMC
November 2018
3 Reads

The glyconanoparticle as carrier for drug delivery.

Drug Deliv 2018 Nov;25(1):1840-1845

b School of Chemistry and Environmental Engineering , Wuhan Institute of Technology , Wuhan , China.

The glyconanoparticle (GlycoNP) has multiple effects and has important applications in drug delivery and bioimaging. It not only has the advantages of nano drug delivery system but also utilizes the characteristics of multivalent interaction of sugar, which greatly improves the targeting of drug delivery. Herein, the application of GlycoNP in drug delivery was analyzed and discussed, the solution to its problem was proposed, and its prospects were forecasted. Read More

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http://dx.doi.org/10.1080/10717544.2018.1519001DOI Listing
November 2018

Versatility of cell-penetrating peptides for intracellular delivery of siRNA.

Drug Deliv 2018 Nov;25(1):1996-2006

a Department of Chemical Engineering , Soonchunhyang University , Asan , Republic of Korea.

The plasma membrane is a large barrier to systemic drug delivery into cells, and it limits the efficacy of drug cargo. This issue has been overcome using cell-penetrating peptides (CPPs). CPPs are short peptides (6-30 amino acid residues) that are potentially capable of intracellular penetration to deliver drug molecules. Read More

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http://dx.doi.org/10.1080/10717544.2018.1543366DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6319457PMC
November 2018

Oncolytic herpes simplex virus tumor targeting and neutralization escape by engineering viral envelope glycoproteins.

Drug Deliv 2018 Nov;25(1):1950-1962

a Faculty of Medicine, The Second School of Clinical Medicine , Yangtze University, Nanhuan , Jingzhou , Hubei , China.

Oncolytic herpes simplex viruses (oHSVs) have been approved for clinical usage and become more and more popular for tumor virotherapy. However, there are still many issues for the oHSVs used in clinics and clinical trials. The main issues are the limited anti-tumor effects, intratumor injection, and some side effects. Read More

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http://dx.doi.org/10.1080/10717544.2018.1534895DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282442PMC
November 2018
3 Reads

Low-density lipoprotein decorated silica nanoparticles co-delivering sorafenib and doxorubicin for effective treatment of hepatocellular carcinoma.

Drug Deliv 2018 Nov;25(1):2007-2014

a Department of Hepato-Biliary-Pancreatic Surgery , First Hospital of Jilin University , Changchun , PR China.

Combinational therapy is usually considered as a preferable approach for effective cancer therapy. Especially, combinational chemotherapies targeting different molecular targets are of particular interest due to its high flexibility as well as efficiency. In our study, the surface of silica nanoparticles (SLN) was modified with low-density lipoprotein (LDL) to construct platform (LDL-SLN) capable of specifically targeting low-density lipoprotein receptors (LDLRs) that overexpressing in hepatocellular carcinoma (HCC). Read More

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http://dx.doi.org/10.1080/10717544.2018.1531953DOI Listing
November 2018

Delivery of magnetic micro/nanoparticles and magnetic-based drug/cargo into arterial flow for targeted therapy.

Drug Deliv 2018 Nov;25(1):1963-1973

c Department of Biological Science , University of Calgary , Calgary , Alberta , Canada.

Magnetic drug targeting (MDT) and magnetic-based drug/cargo delivery are emerging treatment methods which attracting the attention of many researchers for curing different cancers and artery diseases such as atherosclerosis. Herein, computational studies are accomplished by utilizing magnetic approaches for cancer and artery atherosclerosis drug delivery, including nanomagnetic drug delivery and magnetic-based drug/cargo delivery. For the first time, the four-layer structural model of the artery tissue and its porosity parameters are modeled in this study which enables the interaction of particles with the tissue walls in blood flow. Read More

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http://dx.doi.org/10.1080/10717544.2018.1497106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6292362PMC
November 2018

Local release of gemcitabine via in situ UV-crosslinked lipid-strengthened hydrogel for inhibiting osteosarcoma.

Drug Deliv 2018 Nov;25(1):1642-1651

a Department of General Surgery , The Affiliated Hospital of Yangzhou University, Yangzhou University , Yangzhou , P. R. China.

Osteosarcoma is among the most common malignant bone tumors in human skeletal system. The conventional treatment of osteosarcoma mainly consists of combining neoadjuvant chemotherapy with surgical approach. However, it is crucial to design an artificial implant that possesses excellent biomechanical properties and is capable of sustaining local release of chemotherapeutics. Read More

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http://dx.doi.org/10.1080/10717544.2018.1497105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6116704PMC
November 2018

Electrosprayed naringin-loaded microsphere/SAIB hybrid depots enhance bone formation in a mouse calvarial defect model.

Drug Deliv 2019 Dec;26(1):137-146

a Department of Prosthodontics , Stomatological Hospital of Chongqing Medical University , Chongqing , China.

The burst release of active osteogenic factors, which is not beneficial to osteogenesis, is commonly encountered in bone tissue engineering. The aims of this study were to prepare naringin-loaded microsphere/sucrose acetate isobutyrate (Ng-m-SAIB) hybrid depots, reduce the burst release of naringin (Ng), and improve osteogenesis. The morphology and size distributions of electrosprayed Ng-microspheres were characterized by scanning electron microscopy (SEM). Read More

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http://dx.doi.org/10.1080/10717544.2019.1568620DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6394313PMC
December 2019

Cetuximab-modified silica nanoparticle loaded with ICG for tumor-targeted combinational therapy of breast cancer.

Drug Deliv 2019 Dec;26(1):129-136

a Department of Cardiovascular Ultrasonic Diagnosis , the First Affiliated Hospital of China Medical University , Shenyang , China.

Combinational therapy is usually considered as a preferable approach for effective cancer therapy. Especially, combinational chemo and photothermal therapy is of particular interest due to its high flexibility as well as efficiency. In this article, we the silica nanoparticles (SLN) were surface conjugated with Cetuximab (Cet-SLN) to target epidermal growth factor receptor (EGFR), a common receptor that usually observed to overexpress in multiple breast cancers. Read More

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http://dx.doi.org/10.1080/10717544.2018.1564403DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6394284PMC
December 2019

Magnetic aerosol drug targeting in lung cancer therapy using permanent magnet.

Drug Deliv 2019 Dec;26(1):120-128

a Department of Mechanical and Manufacturing Engineering , University of Calgary , Calgary , Alberta , Canada.

Primary bronchial cancer accounts for almost 20% of all cancer death worldwide. One of the emerging techniques with tremendous power for lung cancer therapy is magnetic aerosol drug targeting (MADT). The use of a permanent magnet for effective drug delivery in a desired location throughout the lung requires extensive optimization, but it has not been addressed yet. Read More

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http://dx.doi.org/10.1080/10717544.2018.1561765DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6394297PMC
December 2019
3 Reads

mTHPC-loaded extracellular vesicles outperform liposomal and free mTHPC formulations by an increased stability, drug delivery efficiency and cytotoxic effect in tridimensional model of tumors.

Drug Deliv 2018 Nov;25(1):1790-1801

a CRAN, CNRS UMR 7039 , Université de Lorraine , Nancy , France.

Efficient photodynamic therapy with meta-tetra(hydroxyphenyl)chlorine requires the application of specific nanoformulations. mTHPC liposomal formulation (Foslip) demonstrated favorable pharmacokinetics properties. However, rapid liposomes destruction in circulation and rapid mTHPC release impedes Foslip applications. Read More

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http://dx.doi.org/10.1080/10717544.2018.1513609DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6292368PMC
November 2018

Intranasal administration of erythropoietin rescues the photoreceptors in degenerative retina: a noninvasive method to deliver drugs to the eye.

Drug Deliv 2019 Dec;26(1):78-88

f Department of Neurosurgery and Institute for Functional Brain Disorders , Tangdu Hospital Fourth Military Medical University , Xi'an , PR China.

Inherited retinopathies typically lead to photoreceptor loss and severe visual impairments in the subjects. Intranasal administration is an efficient approach to deliver therapeutic agents to the targeted tissue. The present study is designed to deliver the erythropoietin (EPO) into the N-methyl-N-nitrosourea (MNU) induced mice, a pharmacological retinopathy model via intranasal or intravenous route. Read More

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https://www.tandfonline.com/doi/full/10.1080/10717544.2018.1
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http://dx.doi.org/10.1080/10717544.2018.1556361DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374977PMC
December 2019
4 Reads

Improved drug targeting to liver tumor by sorafenib-loaded folate-decorated bovine serum albumin nanoparticles.

Drug Deliv 2019 Dec;26(1):89-97

a Department of Infectious Diseases, The Second Affiliated Hospital of Nanchang University, School of Pharmaceutical Science , Nanchang University , Nanchang PR China.

Background: To prepare sorafenib-loaded folate-decorated bovine serum nanoparticles (FA-SRF-BSANPs) and investigate their effect on the tumor targeting.

Methods: The nanoparticles were characterized and evaluated by in vivo and in vitro experiments.

Results: SRF-loaded BSA nanoparticles (SRF-BSANPs) was first prepared and modified with folic acid by chemical coupling to obtain FA-SRF-BSANPs. Read More

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https://www.tandfonline.com/doi/full/10.1080/10717544.2018.1
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http://dx.doi.org/10.1080/10717544.2018.1561766DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374969PMC
December 2019
3 Reads

Efficient exosome delivery in refractory tissues assisted by ultrasound-targeted microbubble destruction.

Drug Deliv 2019 Dec;26(1):45-50

a Department of Ultrasound Diagnostics , Tangdu Hospital Fourth Military Medical University , Xi'an, People's Republic of China.

Recently, exosomes have been emerged as promising drug delivery carriers, while certain tissues are intrinsically resistant to exosomes. Therapeutically improving the drug delivery efficiency in these tissues/organs would certainly broaden the potential application of exosomes in future. Ultrasound-targeted microbubble destruction (UTMD) is a promising technique for non-invasive, targeted drug delivery. Read More

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http://dx.doi.org/10.1080/10717544.2018.1534898DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374922PMC
December 2019

Self-assembled angiopep-2 modified lipid-poly (hypoxic radiosensitized polyprodrug) nanoparticles delivery TMZ for glioma synergistic TMZ and RT therapy.

Drug Deliv 2019 Dec;26(1):34-44

a Nanjing Medical University , Nanjing , China.

The addition of temozolomide (TMZ) to radiotherapy (RT) improves survival of patients with glioblastoma (GBM). However, TMZ + RT causes excess toxicity in patients. In this study, we prepared angiopep-2 (A2) modified lipid-poly (hypoxic radiosensitized polyprodrug) nanoparticles for TMZ delivery (A2-P(MIs)25/TMZ) to achieve synergistic effects against glioma. Read More

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https://www.tandfonline.com/doi/full/10.1080/10717544.2018.1
Publisher Site
http://dx.doi.org/10.1080/10717544.2018.1534897DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6394306PMC
December 2019
4 Reads
2.202 Impact Factor

Permeation-enhancing effects and mechanisms of O-acylterpineol on isosorbide dinitrate: mechanistic insights based on ATR-FTIR spectroscopy, molecular modeling, and CLSM images.

Drug Deliv 2019 Dec;26(1):107-119

a School of Pharmacy , North China University of Science and Technology , Tangshan , China.

The present study aimed to evaluate the penetration activity of O-acylterpineol derivatives both in vitro and in vivo, and to investigate the enhancing mechanism of O-acylterpineol derivatives which were synthesized by α-terpineol and fatty acid. The promoting activities on the isosorbide dinitrate patch were tested across full thickness rabbit skin both in vitro and in vivo. In order to elucidate the permeation mechanism, attenuated total reflection Fourier transform infrared spectroscopy, molecular modeling, and confocal laser scanning microscopy were introduced to investigate the regulation of enhancers in the skin permeability and biophysical properties. Read More

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https://www.tandfonline.com/doi/full/10.1080/10717544.2018.1
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http://dx.doi.org/10.1080/10717544.2018.1561764DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374923PMC
December 2019
4 Reads
2.202 Impact Factor