1,665 results match your criteria Drug Delivery[Journal]


Intranasal administration of erythropoietin rescues the photoreceptors in degenerative retina: a noninvasive method to deliver drugs to the eye.

Drug Deliv 2019 Dec;26(1):78-88

f Department of Neurosurgery and Institute for Functional Brain Disorders , Tangdu Hospital Fourth Military Medical University , Xi'an , PR China.

Inherited retinopathies typically lead to photoreceptor loss and severe visual impairments in the subjects. Intranasal administration is an efficient approach to deliver therapeutic agents to the targeted tissue. The present study is designed to deliver the erythropoietin (EPO) into the N-methyl-N-nitrosourea (MNU) induced mice, a pharmacological retinopathy model via intranasal or intravenous route. Read More

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http://dx.doi.org/10.1080/10717544.2018.1556361DOI Listing
December 2019

Improved drug targeting to liver tumor by sorafenib-loaded folate-decorated bovine serum albumin nanoparticles.

Drug Deliv 2019 Dec;26(1):89-97

a Department of Infectious Diseases, The Second Affiliated Hospital of Nanchang University, School of Pharmaceutical Science , Nanchang University , Nanchang PR China.

Background: To prepare sorafenib-loaded folate-decorated bovine serum nanoparticles (FA-SRF-BSANPs) and investigate their effect on the tumor targeting.

Methods: The nanoparticles were characterized and evaluated by in vivo and in vitro experiments.

Results: SRF-loaded BSA nanoparticles (SRF-BSANPs) was first prepared and modified with folic acid by chemical coupling to obtain FA-SRF-BSANPs. Read More

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http://dx.doi.org/10.1080/10717544.2018.1561766DOI Listing
December 2019

Efficient exosome delivery in refractory tissues assisted by ultrasound-targeted microbubble destruction.

Drug Deliv 2019 Dec;26(1):45-50

a Department of Ultrasound Diagnostics , Tangdu Hospital Fourth Military Medical University , Xi'an, People's Republic of China.

Recently, exosomes have been emerged as promising drug delivery carriers, while certain tissues are intrinsically resistant to exosomes. Therapeutically improving the drug delivery efficiency in these tissues/organs would certainly broaden the potential application of exosomes in future. Ultrasound-targeted microbubble destruction (UTMD) is a promising technique for non-invasive, targeted drug delivery. Read More

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http://dx.doi.org/10.1080/10717544.2018.1534898DOI Listing
December 2019

Self-assembled angiopep-2 modified lipid-poly (hypoxic radiosensitized polyprodrug) nanoparticles delivery TMZ for glioma synergistic TMZ and RT therapy.

Drug Deliv 2019 Dec;26(1):34-44

a Nanjing Medical University , Nanjing , China.

The addition of temozolomide (TMZ) to radiotherapy (RT) improves survival of patients with glioblastoma (GBM). However, TMZ + RT causes excess toxicity in patients. In this study, we prepared angiopep-2 (A2) modified lipid-poly (hypoxic radiosensitized polyprodrug) nanoparticles for TMZ delivery (A2-P(MIs)25/TMZ) to achieve synergistic effects against glioma. Read More

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http://dx.doi.org/10.1080/10717544.2018.1534897DOI Listing
December 2019

Permeation-enhancing effects and mechanisms of O-acylterpineol on isosorbide dinitrate: mechanistic insights based on ATR-FTIR spectroscopy, molecular modeling, and CLSM images.

Drug Deliv 2019 Dec;26(1):107-119

a School of Pharmacy , North China University of Science and Technology , Tangshan , China.

The present study aimed to evaluate the penetration activity of O-acylterpineol derivatives both in vitro and in vivo, and to investigate the enhancing mechanism of O-acylterpineol derivatives which were synthesized by α-terpineol and fatty acid. The promoting activities on the isosorbide dinitrate patch were tested across full thickness rabbit skin both in vitro and in vivo. In order to elucidate the permeation mechanism, attenuated total reflection Fourier transform infrared spectroscopy, molecular modeling, and confocal laser scanning microscopy were introduced to investigate the regulation of enhancers in the skin permeability and biophysical properties. Read More

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https://www.tandfonline.com/doi/full/10.1080/10717544.2018.1
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http://dx.doi.org/10.1080/10717544.2018.1561764DOI Listing
December 2019
1 Read

ENHANZE drug delivery technology: a novel approach to subcutaneous administration using recombinant human hyaluronidase 20.

Drug Deliv 2019 Dec;26(1):98-106

a Halozyme Therapeutics, Inc. , San Diego , CA , USA.

ENHANZE drug delivery technology is based on the proprietary recombinant human hyaluronidase PH20 enzyme (rHuPH20; Halozyme Therapeutics, Inc.) that facilitates the subcutaneous (SC) delivery of co-administered therapeutics. rHuPH20 works by degrading the glycosaminoglycan hyaluronan (HA), which plays a role in resistance to bulk fluid flow in the SC space, limiting large volume SC drug delivery, dispersion, and absorption. Read More

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http://dx.doi.org/10.1080/10717544.2018.1551442DOI Listing
December 2019

Stereoselectivity evaluation of chiral chitosan microspheres delivery system containing rac-KET in vitro and in vivo.

Drug Deliv 2019 Dec;26(1):63-69

a Institute of Materia Medica, Zhejiang Academy of Medical Sciences , Hangzhou , China.

The influence of chiral excipient D-chitosan (CS) on the stereoselective release of racemic ketoprofen (rac-KET) microspheres has been investigated in comparison to those microspheres containing individual enantiomers in vitro and in vivo. Stereoselectivity was observed in vitro release test, with R-KET release slightly higher than that of S-KET, especially in 3% rac-KET loading microspheres. Stereoselectivity is dependent on the content of chiral excipient and pH of release medium. Read More

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http://dx.doi.org/10.1080/10717544.2018.1556360DOI Listing
December 2019

Rhodotorula glutinis as a living cell liposome to deliver polypeptide drugs in vivo.

Drug Deliv 2019 Dec;26(1):51-62

a College of Pharmacy, Institute of Genomic Medicine, Jinan University , Guangzhou , China.

The potential advantages of recombinant microbes as oral drug carriers for curing diseases have attracted much attention. The use of recombinant oil microbes as living cell liposomes to carry polypeptide drugs may be an ideal polypeptide oral drug delivery system. GM4-ΔTS was constructed by LFH-PCR from Rhodotorula glutinis GM4, which was screened and preserved in our laboratory, and then transferred into choline-phosphate cytidylyltransferase (CCT), which is a rate-limiting enzyme for lecithin synthesis. Read More

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http://dx.doi.org/10.1080/10717544.2018.1551439DOI Listing
December 2019

Design, characterization and comparison of transdermal delivery of colchicine via borneol-chemically-modified and borneol-physically-modified ethosome.

Drug Deliv 2019 Dec;26(1):70-77

a State Key Laboratory of Bioactive Substance and Function of Natural Medicines & Beijing Key laboratory of Drug Delivery Technology and Novel Formulation, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College , Beijing , China.

Gout is a kind of joint disease characterized by the accumulation of monosodium urate (MSU) crystals in the joint and its surrounding tissue, causing persistent hyperuricemia. Colchicine is the first choice of treatment for acute gout attacks. Due to strong toxicity of colchicines oral tablets, there are high fluctuations of blood drug concentration and serious irritation of gastrointestinal tract, and hence a transdermal preparation can help to slow down the blood drug concentration, reduce the frequency of drug taking, and improve the patients' compliance of the drug. Read More

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http://dx.doi.org/10.1080/10717544.2018.1559258DOI Listing
December 2019
1 Read

Photodynamic therapy - hypericin tetraether liposome conjugates and their antitumor and antiangiogenic activity.

Drug Deliv 2019 Dec;26(1):23-33

a Department of Pharmaceutics and Biopharmaceutics , University of Marburg , Marburg , Germany.

Photodynamic therapy (PDT) is an established noninvasive tumor treatment. The hydrophobic natural occurring pigment hypericin shows a lot of attractive properties for the application in PDT. Hence, the administration to biological systems or patients requires the formulation in drug carriers enabling sufficient bioavailability. Read More

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http://dx.doi.org/10.1080/10717544.2018.1531954DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352941PMC
December 2019

Enhanced chemotherapeutic efficacy of the low-dose doxorubicin in breast cancer via nanoparticle delivery system crosslinked hyaluronic acid.

Drug Deliv 2019 Dec;26(1):12-22

a Department of Pathology, Institutes of Biology and Medical Sciences , Soochow University Medical College, Soochow University , Suzhou P. R. China.

Despite the development of treatment options in breast cancer, many patients die of recurrence and metastasis. Owing to enhanced permeability and retention in solid tumor tissue, nanoparticle (NP) delivery systems have been emerged as novel strategy in cancer chemotherapy. As extracellular matrix, glycosaminoglycan hyaluronan (HA) could bind its surface receptor adhesion molecule CD44 which is strongly expressed on breast cancer. Read More

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http://dx.doi.org/10.1080/10717544.2018.1507057DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352940PMC
December 2019
1 Read

Identification and imaging of miR-155 in the early screening of lung cancer by targeted delivery of octreotide-conjugated chitosan-molecular beacon nanoparticles.

Drug Deliv 2018 Nov;25(1):1974-1983

f Cancer Institute of PLA, Xinqiao Hospital, Army Medical University , Chongqing , China.

Lung cancer is still the most common cancer globally. Early screening remains the key to improve the prognosis of patients. There is currently a lack of specific and sensitive methods for early screening of lung cancer. Read More

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https://www.tandfonline.com/doi/full/10.1080/10717544.2018.1
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http://dx.doi.org/10.1080/10717544.2018.1516003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327580PMC
November 2018
6 Reads

Antitumor activities of novel glycyrrhetinic acid-modified curcumin-loaded cationic liposomes in vitro and in H22 tumor-bearing mice.

Drug Deliv 2018 Nov;25(1):1984-1995

b Hubei Provincial Hospital of Traditional Chinese Medicine , Wuhan , P.R. China.

At present, the chemotherapy of advanced inoperable liver cancer is limited with serious side effects. Curcumin possesses multiple cancer preventive activities and low safety concerns. However, its poor solubility and instability in water pose significant pharmacological barriers to its clinical application. Read More

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http://dx.doi.org/10.1080/10717544.2018.1526227DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282420PMC
November 2018
1 Read

Dual-modified natural high density lipoprotein particles for systemic glioma-targeting drug delivery.

Drug Deliv 2018 Nov;25(1):1865-1876

b State Key Laboratory of Toxicology and Medical Countermeasures , Beijing Institute of Pharmacology and Toxicology , Beijing , China.

Therapeutic outcome for the treatment of glioma was often limited due to the two barriers involved: the blood-brain barrier (BBB) and blood-brain tumor barrier (BBTB). Therefore, the development of nanocarriers that possess both BBB and BBTB permeability and glioma-targeting ability is of great importance for the chemotherapy of glioma. New frontiers in nanomedicine are advancing the research of new biomaterials. Read More

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http://dx.doi.org/10.1080/10717544.2018.1519002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6263114PMC
November 2018
3 Reads
2.202 Impact Factor

Laser-assisted delivery enhances topical uptake of the anticancer agent cisplatin.

Drug Deliv 2018 Nov;25(1):1877-1885

a Department of Dermatology , Bispebjerg Hospital, University of Copenhagen , Copenhagen NV , Denmark.

Systemic chemotherapy with the anticancer agent cisplatin is approved for advanced non-melanoma skin cancer (NMSC), but topical treatment is limited by insufficient cutaneous penetration. We studied the impact of ablative fractional laser (AFL) exposure on topical cisplatin's pharmacokinetics and biodistribution in skin, using microscopic ablation zones reaching the mid- (MAZ-MD; 620 μm depth) and deep dermis (MAZ-DD; 912 μm depth) (λ = 10,600 nm, 196 MAZ/cm). Assessed in an in vitro Franz cell model after 0. Read More

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https://www.tandfonline.com/doi/full/10.1080/10717544.2018.1
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http://dx.doi.org/10.1080/10717544.2018.1534896DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6263115PMC
November 2018
12 Reads

Development of dual-drug-loaded stealth nanocarriers for targeted and synergistic anti-lung cancer efficacy.

Drug Deliv 2018 Nov;25(1):1932-1942

c Department of Materials Science and Engineering College of Materials , Xiamen University , Xiamen , P. R. China.

Combination chemotherapy is widely exploited for suppressing drug resistance and achieving synergistic anticancer efficacy in the clinic. In this paper, the nanostructured targeting methotrexate (MTX) plus pemetrexed (PMX) chitosan nanoparticles (CNPs) were developed by modifying methoxy polye (thylene glycol) (mPEG), in which PEGylation CNPs was used as stealth nanocarriers (PCNPs) and MTX was employed as a targeting ligand and chemotherapeutic agent as well. Studies were undertaken on human lung adenocarcinoma epithelial (A549) and Lewis lung carcinoma (LLC) cell lines, revealing the anti-tumor efficacy of nanoparticle drug delivery system. Read More

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https://www.tandfonline.com/doi/full/10.1080/10717544.2018.1
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http://dx.doi.org/10.1080/10717544.2018.1477856DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6263111PMC
November 2018
8 Reads

Primary M1 macrophages as multifunctional carrier combined with PLGA nanoparticle delivering anticancer drug for efficient glioma therapy.

Drug Deliv 2018 Nov;25(1):1922-1931

a Key Laboratory of Smart Drug Delivery, Ministry of Education & Department of Pharmaceutics, Schoolof Pharmacy , Fudan University , Shanghai , China.

Glioma remains difficult to treat because of the infiltrative growth of tumor cells and their resistance to standard therapy. Despite rapid development of targeted drug delivery system, the current therapeutic efficacy is still challenging. Based on our previous studies, macrophages have been proved to be promising drug carrier for active glioma delivery. Read More

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http://dx.doi.org/10.1080/10717544.2018.1502839DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6263108PMC
November 2018
11 Reads

Designing multifunctional cancer-targeted nanosystem for magnetic resonance molecular imaging-guided theranostics of lung cancer.

Drug Deliv 2018 Nov;25(1):1811-1825

a Medical Imaging Center , First Affiliated Hospital of Jinan University , Guangzhou , China.

The integration of diagnosis and therapy is an effective way to improve therapeutic effects for cancer patients, which has acquired widely attentions from researchers. Herein, a multifunctional drug-loaded nanosystem (F/A-PLGA@DOX/SPIO) has been designed and synthesized to reduce the side effects of traditional chemotherapy drugs and realize simultaneous tumor diagnosis and treatment. The surface modification of folic acid (FA) and activatable cell-penetrating peptide (ACPP) endows the nanosystem with excellent cancer targeting capabilities, thus reducing toxicity to normal organs. Read More

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http://dx.doi.org/10.1080/10717544.2018.1494224DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6263109PMC
November 2018
12 Reads
2.202 Impact Factor

Effects of solvents and penetration enhancers on transdermal delivery of thymoquinone: permeability and skin deposition study.

Drug Deliv 2018 Nov;25(1):1943-1949

a Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers , The State University of New Jersey , Piscataway , NJ , USA.

Thymoquinone (TQ) is a quinone-based phytochemical that was first identified in 1963 in Nigella sativa (black cumin seed) by El-Dakhakhany. Based on the ideal characteristics of transdermal delivery, TQ is potentially an attractive candidate for transdermal drug delivery. The aim of this study was to investigate the feasibility of transdermal delivery of TQ and to assess the effect of an ethanol and propylene glycol donor solvent system along with various compositions of receptor solvents. Read More

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http://dx.doi.org/10.1080/10717544.2018.1523256DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6249612PMC
November 2018
2 Reads

Multistage delivery of CDs-DOX/ICG-loaded liposome for highly penetration and effective chemo-photothermal combination therapy.

Drug Deliv 2018 Nov;25(1):1826-1839

a Department of Pharmaceutics, School of Pharmacy , Shenyang Pharmaceutical University , Shenyang , P.R. China.

Nanoparticles (NPs) have proven to be effective drug carriers in diagnosis and therapy of cancer. But, they faced a contradictory issue that NPs with large size appear weak tumor penetration, meanwhile small size resulted in poor tumor retention. Herein, we fabricated doxorubicin conjugated carbon dots (CDs-DOX) and indocyanine green (ICG)-loaded liposomes (ICG-LPs) named CDs-ICG-LPs using a modified reverse phase evaporation process, and with high incorporation in the aqueous core. Read More

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http://dx.doi.org/10.1080/10717544.2018.1482975DOI Listing
November 2018
7 Reads

Design, characterization and in vivo evaluation of nanostructured lipid carriers (NLC) as a new drug delivery system for hydrochlorothiazide oral administration in pediatric therapy.

Drug Deliv 2018 Nov;25(1):1910-1921

c Department of Neuroscience, Psychology, Drug Research and Child Health (NEUROFARBA), Pharmacology and Toxicology Section , University of Florence , Florence , Italy.

The hydrochlorothiazide (HCT) low solubility and permeability give rise to limited and variable bioavailability; its low stability makes it difficult to develop stable aqueous liquid formulations; its low dose makes the achievement of a homogeneous drug distribution very difficult. Thus, the aim of this study was to investigate the effectiveness of a strategy based on the development of nanostructured lipid carriers (NLC) as an innovative oral pediatric formulation of HCT with improved therapeutic efficacy. The performance of various synthetic and natural liquid lipids was examined and two different preparation methods were employed, i. Read More

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https://www.tandfonline.com/doi/full/10.1080/10717544.2018.1
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http://dx.doi.org/10.1080/10717544.2018.1529209DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6249610PMC
November 2018
7 Reads

Solutol HS15 based binary mixed micelles with penetration enhancers for augmented corneal delivery of sertaconazole nitrate: optimization, in vitro, ex vivo and in vivo characterization.

Drug Deliv 2018 Nov;25(1):1706-1717

a Department of Pharmaceutics and industrial pharmacy, Faculty of pharmacy , Cairo University , Cairo , Egypt.

Keratomycosis is a serious corneal disease that can cause a permanent visual disability if not treated effectively. Sertaconazole nitrate (STZ), a novel broad spectrum antifungal drug, was suggested as a promising treatment. However, its utility in the ocular route is restricted by its poor solubility, along with other problems facing the ocular delivery like short residence time, and the existing corneal barrier. Read More

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http://dx.doi.org/10.1080/10717544.2018.1497107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6249589PMC
November 2018
11 Reads

A Bayesian network meta-analysis on the efficacy and safety of eighteen targeted drugs or drug combinations for pulmonary arterial hypertension.

Drug Deliv 2018 Nov;25(1):1898-1909

c Department Respiration , Dongfang Hospital Beijing University of Chinese Medicine , Beijing , China.

Pulmonary arterial hypertension (PAH) can be relieved by pharmacological interventions, especially the targeted drug, which is classified into endothelin receptor antagonist, phosphodiesterase 5 inhibitor, prostaglandin I, soluble guanylate cyclase stimulator and selective non-prostanoid prostacyclin receptor agonist. To solve the contradictions existing in reported trials and provide a comprehensive guideline for clinical practice. PubMed, Embase, Cochrane library, and clinicaltrials. Read More

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http://dx.doi.org/10.1080/10717544.2018.1523257DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6249551PMC
November 2018
2 Reads

Potential combination topical therapy of anal fissure: development, evaluation, and clinical study†.

Drug Deliv 2018 Nov;25(1):1672-1682

a Faculty of Pharmacy, Department of Pharmaceutics , Mansoura University , Mansoura , Egypt.

To treat anal fissure, internal anal sphincterotomy may be associated with surgical risks and incidence of incontinence. Botulinum toxin injection into the anal sphincter is invasive and expensive. Headache and hypotension hindered topical treatment with glyceryl trinitrate. Read More

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https://www.tandfonline.com/doi/full/10.1080/10717544.2018.1
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http://dx.doi.org/10.1080/10717544.2018.1507059DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6237160PMC
November 2018
19 Reads

Brain-targeted delivery of PEGylated nano-bacitracin A against Penicillin-sensitive and -resistant Pneumococcal meningitis: formulated with RVG and Pluronic P85 unimers.

Drug Deliv 2018 Nov;25(1):1886-1897

a Key Laboratory of Zoonosis of Liaoning Province, College of Animal Science and Veterinary Medicine, Shenyang Agricultural University , Shenyang , P.R. China.

Pneumococcal meningitis (PM), caused by Streptococcus pneumonia, remains a high-burden disease in developing countries. Antibiotic therapy has been limited due to the inefficiency of drug transport across the blood-brain barrier (BBB) and the emergence of drug-resistant strains. In our preliminary study, PEGylated nano-self-assemblies of bacitracin A (PEGylated Nano-BA) demonstrated a strong antibacterial potency against S. Read More

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http://dx.doi.org/10.1080/10717544.2018.1486473DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6225518PMC
November 2018
1 Read

Enhanced blood-brain barrier penetration and glioma therapy mediated by T7 peptide-modified low-density lipoprotein particles.

Drug Deliv 2018 Nov;25(1):1652-1663

a State Key Laboratory of Toxicology and Medical Countermeasures , Beijing Institute of Pharmacology and Toxicology , Beijing , China.

Therapeutic outcome for the treatment of glioma was often limited due to the non-targeted nature and low permeability of drugs across the blood-brain barrier (BBB). An ideal glioma-targeted delivery system need to traverse the BBB and then target glioma cells with adequate optimized physiochemical properties and biocompatibility. However, it is an enormous challenge to the researchers to engineer the above-mentioned features into a single nanocarrier particle. Read More

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http://dx.doi.org/10.1080/10717544.2018.1494223DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6225487PMC
November 2018
6 Reads
2.200 Impact Factor

The challenges of oral drug delivery via nanocarriers.

Drug Deliv 2018 Nov;25(1):1694-1705

a Department of Dermatology , University Medical Center of the Johannes Gutenberg-University Mainz , Mainz , Germany.

The oral application of pharmaceuticals is unarguably the most convenient method of application. Especially for protein- or peptide-based drugs, however, the effectiveness is significantly reduced due to enzymatic digestion in the stomach as well as a poor bioavailability in the small intestine. For these difficult formulations, the encapsulation into nanocarriers would protect the sensitive drug and thus could considerably improve the efficiency of oral drug delivery. Read More

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https://www.tandfonline.com/doi/full/10.1080/10717544.2018.1
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http://dx.doi.org/10.1080/10717544.2018.1501119DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6225504PMC
November 2018
8 Reads

PD-1/PD-L1 pathway and angiogenesis dual recognizable nanoparticles for enhancing chemotherapy of malignant cancer.

Drug Deliv 2018 Nov;25(1):1746-1755

b Shanghai University of Medicine and Health Sciences Affiliated Sixth People's Hospital South Campus , Shanghai , China.

Although the cancer immunotherapy represents one of the most promising strategies for cancer treatment, the PD-1/PD-L1 pathway, which involves a receptor-ligand interaction, can induced immunosuppression by disabling tumor-infiltrating lymphocytes (TILs). In the present study, we coupled a PD-L1 (Programmed cell death 1 ligand 1) recognizable peptide DPPA-1 to the sequence of CGKRK, a namely tumor vasculature affinity peptide, to form a new molecule CD peptide. Thereafter, the paclitaxel (PTX)-loaded PCL nanoparticles were developed and modified with the above newly synthesized CD molecules for tumor cells and angiogenesis dual targeting drug delivery. Read More

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https://www.tandfonline.com/doi/full/10.1080/10717544.2018.1
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http://dx.doi.org/10.1080/10717544.2018.1509907DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6225483PMC
November 2018
16 Reads

Stacking of doxorubicin on folic acid-targeted multiwalled carbon nanotubes for in vivo chemotherapy of tumors.

Drug Deliv 2018 Nov;25(1):1607-1616

b Department of Radiology , Huadong Hospital, Fudan University , Shanghai , P. R. China.

In this work, we developed a novel active targeting and pH-responsive system for delivering the drug doxorubicin (DOX) to tumor sites using folic acid (FA)-modified multiwalled carbon nanotubes (MWCNTs). Acid-treated MWCNTs with carboxyl groups were first covalently conjugated with polyethyleneimine (PEI). Subsequent sequential modification with FA (via a polyethylene glycol spacer), fluorescein isothiocyanate (FI), and acetic anhydride/triethylamine resulted in multifunctional FA-bound MWCNT (MWCNT-PEI. Read More

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http://dx.doi.org/10.1080/10717544.2018.1501120DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6201812PMC
November 2018
8 Reads
2.202 Impact Factor

Ganoderma lucidum-derived polysaccharide enhances coix oil-based microemulsion on stability and lung cancer-targeted therapy.

Drug Deliv 2018 Nov;25(1):1802-1810

a Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine , Nanjing , China.

The aim of this study is to explore the influence of Ganoderma lucidum-derived polysaccharides (GLP) to coix oil-based microemulsion on pharmaceutical performance and anti-lung cancer treatment. GLP-integrated coix oil-based microemulsion (MEs(PS-GLP)) exhibited a clear spherical shape, small particle size, and good hydrodynamics similar to the coix oil-based microemulsion, but showed a lower zeta potential and a better stability. Fluorescence resonance energy transfer analysis presented that GLP was integrated with microemulsion as a single system. Read More

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https://www.tandfonline.com/doi/full/10.1080/10717544.2018.1
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http://dx.doi.org/10.1080/10717544.2018.1516006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6201799PMC
November 2018
16 Reads

Dual-mode imaging and therapeutic effects of drug-loaded phase-transition nanoparticles combined with near-infrared laser and low-intensity ultrasound on ovarian cancer.

Drug Deliv 2018 Nov;25(1):1683-1693

a Department of Obstetrics and Gynecology , The Second Affiliated Hospital of Chongqing Medical University , Chongqing , PR China.

Chemotherapy and photo-sonodynamic therapy (PSDT) can be combined through drug delivery nano-platforms to enhance the anti-tumor efficacy, however, which is limited by hypoxia in tumor, thereby causing chemotherapy resistance. Perfluoropentane (PFP) has the ability to carry oxygen and to enhance ultrasound or photoacoustic imaging after vaporization. Herein, we constructed a kind of nanoparticles (PTX/ICG and oxygen loaded PLGA nanoparticles (PIO_NPs)), which had PFP core carrying oxygen and PLGA shell loaded indocyanine green (ICG) and paclitaxel (PTX). Read More

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http://dx.doi.org/10.1080/10717544.2018.1507062DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6201789PMC
November 2018
2 Reads

Co-delivery of deferoxamine and hydroxysafflor yellow A to accelerate diabetic wound healing via enhanced angiogenesis.

Drug Deliv 2018 Nov;25(1):1779-1789

a Institute of Pharmaceutics, College of Pharmaceutical Sciences , Zhejiang University , Hangzhou, Zhejiang , P.R. China.

Nonhealing chronic wounds on foot induced by diabetes is a complicated pathologic process. They are mainly caused by impaired neovascularization, neuropathy, and excessive inflammation. A strategy, which can accelerate the vessel network formation as well as inhibit inflammatory response at the same time, makes it possible for effective diabetic ulcers treatment. Read More

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http://dx.doi.org/10.1080/10717544.2018.1513608DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6201774PMC
November 2018
2 Reads

Development and characterization of sorafenib-loaded lipid nanocapsules for the treatment of glioblastoma.

Drug Deliv 2018 Nov;25(1):1756-1765

a Département de Neurochirurgie , CHU , Angers , France.

Anticancer agents that target both tumor cells and angiogenesis are of potential interest for glioblastoma (GB) therapy. One such agent is sorafenib (SFN), a tyrosine kinase inhibitor. However, poor aqueous solubility and undesirable side effects limit its clinical application, including local treatment. Read More

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http://dx.doi.org/10.1080/10717544.2018.1507061DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6225440PMC
November 2018
1 Read

Borneol and Α-asarone as adjuvant agents for improving blood-brain barrier permeability of puerarin and tetramethylpyrazine by activating adenosine receptors.

Drug Deliv 2018 Nov;25(1):1858-1864

a Department of Pharmacy , The Second Xiangya Hospital, Central South University , Changsha , Hunan , China.

Puerarin (PUE) and tetramethylpyrazine (TMP) are central nervous system (CNS) drugs used in cerebrovascular diseases. Poor brain-blood barrier (BBB) permeability limited their clinical application. Borneol and α-asarone have been proposed as an oral brain-targeting enhancer. Read More

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https://www.tandfonline.com/doi/full/10.1080/10717544.2018.1
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http://dx.doi.org/10.1080/10717544.2018.1516005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6201807PMC
November 2018
4 Reads

A novel redox/pH dual-responsive and hyaluronic acid-decorated multifunctional magnetic complex micelle for targeted gambogic acid delivery for the treatment of triple negative breast cancer.

Drug Deliv 2018 Nov;25(1):1846-1857

a Key Laboratory of Drug Quality Control and Pharmacovigilance, Ministry of Education , China Pharmaceutical University , Nanjing , People's Republic of China.

Gambogic acid (GA) is a naturally derived potent anticancer agent with extremely poor biocompatibility. In the present study, a novel of redox/pH dual-responsive multifunctional magnetic complex micelle (sPEG/HA/CSO-SS-Hex/FeO/GA), which consisted of a reducible hexadecanol-modified chitosan oligosaccharide polymer micelle (CSO-SS-Hex) coated with hyaluronic acid (HA) and DCA grafted sheddable PEG-PLL (sPEG) copolymers and loaded with gambogic acid (GA) and FeO nanoparticles were developed for parenteral delivery for the treatment of triple negative breast cancer (TNBC). The ex vivo study showed that the sPEG shielded cationic HA/CSO-SS-Hex/FeO/GA core at physiological pH but quickly shed off to re-expose the core due to its charge reversible property. Read More

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http://dx.doi.org/10.1080/10717544.2018.1486472DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6225507PMC
November 2018
2 Reads

Borneol, a messenger agent, improves central nervous system drug delivery through enhancing blood-brain barrier permeability: a preclinical systematic review and meta-analysis.

Drug Deliv 2018 Nov;25(1):1617-1633

a Department of Cardiology , The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University , Wenzhou , PR China.

To achieve sufficient blood-brain barrier (BBB), penetration is one of the biggest challenges in the development of diagnostic and therapeutic for central nervous system (CNS) disorders. Here, we conducted a systematic review and meta-analysis to assess the preclinical evidence and possible mechanisms of borneol for improving co-administration of CNS drug delivery in animal models. The electronic literature search was conducted in six databases. Read More

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http://dx.doi.org/10.1080/10717544.2018.1486471DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6225363PMC
November 2018
3 Reads

A journey from the endothelium to the tumor tissue: distinct behavior between PEO-PCL micelles and polymersomes nanocarriers.

Drug Deliv 2018 Nov;25(1):1766-1778

a Institut de Pharmacologie et Biologie Structurale, IPBS , Université de Toulouse, CNRS, UPS , Toulouse , France.

Polymeric nanocarriers must overcome several biological barriers to reach the vicinity of solid tumors and deliver their encapsulated drug. This study assessed the in vitro and in vivo passage through the blood vessel wall to tumors of two well-characterized polymeric nanocarriers: poly(ethyleneglycol-b-ε-caprolactone) micelles and polymersomes charged with a fluorescent membrane dye (DiO: 3,3'-dioctadecyloxacarbo-cyanine perchlorate). The internalization and translocation from endothelial (human primary endothelial cells HUVEC) to cancer cells (human tumor cell line HCT-116) was studied in conventional 2D monolayers, 3D tumor spheroids, or in an endothelium model based on transwell assay. Read More

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http://dx.doi.org/10.1080/10717544.2018.1510064DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6197035PMC
November 2018
1 Read

Dual-modified cationic liposomes loaded with paclitaxel and survivin siRNA for targeted imaging and therapy of cancer stem cells in brain glioma.

Drug Deliv 2018 Nov;25(1):1718-1727

a Department of Oncology, Tongren Hospital , Shanghai Jiao Tong University School of Medicine , Shanghai , PR China.

Development of safe, efficient nanocomplex for targeted imaging and therapy of cancer stem cells in brain glioma has become a great challenge. Herein, a low-density lipoprotein receptor-related protein and a RNA aptamer bound CD133 were used as dual-targeting ligands to prepare dual-modified cationic liposomes (DP-CLPs) loaded with survivin siRNA and paclitaxel (DP-CLPs-PTX-siRNA) for actively targeting imaging and treating CD133 glioma stem cells after passing through the blood-brain barrier. After being administrated with DP-CLPs-PTX-siRNA nanocomplex, DP-CLPs showed a persistent target ability to bind glioma cells and brain microvascular endothelial cells (BCECs) and to deliver drugs (PTX/siRNA) to CD133 glioma stem cells. Read More

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http://dx.doi.org/10.1080/10717544.2018.1494225DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6171435PMC
November 2018
4 Reads

Enhanced gene transfection efficiency by low-dose 25 kDa polyethylenimine by the assistance of 1.8 kDa polyethylenimine.

Drug Deliv 2018 Nov;25(1):1740-1745

a Laboratory of Ultrasound Molecular Imaging, Department of Ultrasound Medicine , The Third Affiliated Hospital of Guangzhou Medical University , Guangzhou , China.

Gene therapy is a promising strategy for treatments of various diseases. Efficient and safe introduction of therapeutic genes into targeted cells is essential to realize functions of the genes. High-molecular-weight polyethylenimines (HMW PEIs) including 25 kDa branched PEI and 22 kDa linear PEI are widely used for in vitro gene transfection. Read More

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http://dx.doi.org/10.1080/10717544.2018.1510065DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6161618PMC
November 2018
5 Reads

A local drug delivery system based on visible light-cured glycol chitosan and doxorubicin⋅hydrochloride for thyroid cancer treatment in vitro and in vivo.

Drug Deliv 2018 Nov;25(1):1664-1671

h Institute of Cell and Tissue Engineering, College of Medicine , The Catholic University of Korea , Seoul , Republic of Korea.

Systemic drug delivery systems (SDDSs) for thyroid cancer treatment are associated with serious side effects including nausea, anorexia, and hair loss as a result of damage to normal tissues. In this study, we investigated the feasibility of a local DDS (LDDS) based on visible light-cured glycol chitosan (GC) hydrogel and doxorubicin⋅hydrochloride (DOX⋅HCl), called GC10/DOX, on thyroid cancer treatment in vivo. Visible light irradiation increased the storage modulus and swelling ratio of the GC10/DOX hydrogel precursor. Read More

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http://dx.doi.org/10.1080/10717544.2018.1507058DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6127840PMC
November 2018
2 Reads

Touch-actuated microneedle array patch for closed-loop transdermal drug delivery.

Drug Deliv 2018 Nov;25(1):1728-1739

a Guangdong Provincial Key Laboratory of Sensor Technology and Biomedical Instrument, School of Biomedical Engineering , Sun Yat-Sen University , Guangzhou , PR China.

To date, only approximately 20 drugs synthesized with small molecules have been approved by the FDA for use in traditional transdermal patches (TTP) owing to the extremely low permeation rate of the skin barrier for macromolecular drugs. A novel touch-actuated microneedle array patch (TMAP) was developed for transdermal delivery of liquid macromolecular drugs. TMAP is a combination of a typical TTP and a solid microneedle array (MA). Read More

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http://dx.doi.org/10.1080/10717544.2018.1507060DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6127806PMC
November 2018
11 Reads

Nose-to-brain delivery of temozolomide-loaded PLGA nanoparticles functionalized with anti-EPHA3 for glioblastoma targeting.

Drug Deliv 2018 Nov;25(1):1634-1641

a School of Pharmacy , Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Yantai University , Yantai , China.

Glioblastoma is the most common malignant brain tumor. Efficient delivery of drugs targeting glioblastomas remains a challenge. Ephrin type-A receptor 3 (EPHA3) tyrosine kinase antibody-modified polylactide-co-glycolide (PLGA) nanoparticles (NPs) were developed to target glioblastoma via nose-to-brain delivery. Read More

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http://dx.doi.org/10.1080/10717544.2018.1494226DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6127843PMC
November 2018
8 Reads

Curcumin-loaded PLGA-PEG nanoparticles conjugated with B6 peptide for potential use in Alzheimer's disease.

Drug Deliv 2018 Nov;25(1):1091-1102

a Department of Neurology , Sun Yat-sen Memorial Hospital, Sun Yat-sen University , Guangzhou , China.

Alzheimer's disease is a neurodegenerative disorder mainly characterized by β-amyloid deposit and tau hyperphosphorylation with no curative treatments. Curcumin (Cur) has been proved to have potential use in Alzheimer's disease with its anti-amyloid, anti-inflammatory, and anti-oxidant properties, etc. However, its hydrophobicity and low bioavailability hinder its application. Read More

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http://dx.doi.org/10.1080/10717544.2018.1461955DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6116673PMC
November 2018
5 Reads
2.200 Impact Factor

Sodium stibogluconate loaded nano-deformable liposomes for topical treatment of leishmaniasis: macrophage as a target cell.

Drug Deliv 2018 Nov;25(1):1595-1606

a Department of Pharmacy, Faculty of Biological Sciences , Quaid-i-Azam University , Islamabad , Pakistan.

Topical drug delivery against cutaneous leishmaniasis (CL) signifies an effective alternate for improving the availability and reducing the toxicity associated with the parenteral administration of conventional sodium stibogluconate (SSG) injection. The basic aim of the study was to develop nano-deformable liposomes (NDLs) for the dermal delivery of SSG against CL. NDLs were formulated by a modified thin film hydration method and optimized via Box-Behnken statistical design. Read More

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http://dx.doi.org/10.1080/10717544.2018.1494222DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6095017PMC
November 2018
6 Reads

Self-assembled PEGylated albumin nanoparticles (SPAN) as a platform for cancer chemotherapy and imaging.

Drug Deliv 2018 Nov;25(1):1570-1578

a School of Pharmacy, Theranostic Macromolecules Research Center , Sungkyunkwan University , Suwon , Republic of Korea.

Paclitaxel (PTX) is used as a major antitumor agent for the treatment of recurrent and metastatic breast cancer. For the clinical application of PTX, it needs to be dissolved in an oil/detergent-based solvent due to its poor solubility in an aqueous medium. However, the formulation often causes undesirable complications including hypersensitivity reactions and limited tumor distribution, resulting in a lower dose-dependent antitumor effect. Read More

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http://dx.doi.org/10.1080/10717544.2018.1489430DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6060380PMC
November 2018
7 Reads

Modified translationally controlled tumor protein-derived protein transduction domain enhances nasal delivery of exendin-4 as shown with insulin.

Drug Deliv 2018 Nov;25(1):1579-1584

a Graduate School of Pharmaceutical Sciences, College of Pharmacy , Ewha Womans University , Seoul , South Korea.

Protein transduction domains (PTDs) have been shown to promote the delivery of therapeutic proteins or peptides into the living cells. In a previous study, we showed that the double mutant of TCTP-PTD 13, TCTP-PTD 13M2, was more effective in the delivery of insulin than the wild-type TCTP-PTD 13. In this study, we applied this approach to the nasal delivery of a different peptide, exendin-4, using as carriers, several modified TCTP-PTDs, such as TCTP-PTD 13M1, 13M2, and 13M3. Read More

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http://dx.doi.org/10.1080/10717544.2018.1491653DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6096457PMC
November 2018
3 Reads

Intravenous delivery of a liposomal formulation of voriconazole improves drug pharmacokinetics, tissue distribution, and enhances antifungal activity.

Drug Deliv 2018 Nov;25(1):1585-1594

a Faculty of Pharmacy, Laboratory of Pharmaceutical Technology - FamaTec , Federal University of Goiás , Goiânia , Brazil.

Voriconazole (VCZ), a triazole with a large spectrum of action is one of the most recommended antifungal agents as the first line therapy against several clinically important systemic fungal infections, including those by Candida albicans. This antifungal has moderate water solubility and exhibits a nonlinear pharmacokinetic (PK) profile. By entrapping VCZ into liposomes, it is possible to circumvent certain downsides of the currently available product such as a reduction in the rate of its metabolization into an inactive form, avoidance of the toxicity of the sulfobutyl ether-beta-cyclodextrin (SBECD), vehicle used to increase its solubility. Read More

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http://dx.doi.org/10.1080/10717544.2018.1492046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6060385PMC
November 2018
13 Reads

Efficient treatment of Parkinson's disease using ultrasonography-guided rhFGF20 proteoliposomes.

Drug Deliv 2018 Nov;25(1):1560-1569

a School of Pharmaceutical Sciences & Center for Structural Biology , Wenzhou Medical University , Wenzhou , Zhejiang , China.

Fibroblast growth factor-20 (FGF20) is a paracrine member of the FGF family that is preferentially expressed in the substantia nigra pars compacta (SNpc). Previous studies have demonstrated that FGF20 enhances the survival of dopaminergic neurons suggesting the potential use of FGF20 to treat Parkinson's disease (PD). However, the reduced solubility of the bacterial recombinant human FGF20 (rhFGF20) and the absence of efficient strategies to transport rhFGF20 across the blood-brain barrier (BBB) have halted its clinical application. Read More

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http://dx.doi.org/10.1080/10717544.2018.1482972DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6060384PMC
November 2018
15 Reads
2.202 Impact Factor

Superior anti-neoplastic activities of triacontanol-PEG conjugate: synthesis, characterization and biological evaluations.

Drug Deliv 2018 Nov;25(1):1546-1559

b Nanjing Tech University , Nanjing , China.

Triacontanol (TA, CHO), abundantly present in plant cuticle waxes and bee waxes, has been found to display promising anti-neoplastic potentials. As a long chain fatty alcohol, TA possesses limited aqueous solubility, which hinders its medicinal application. To overcome its solubility barrier, a polymer prodrug was synthesized through attaching TA to poly ethylene glycol (PEG), using succinic acid as a linker with bifunctional amide and ester bonds. Read More

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http://dx.doi.org/10.1080/10717544.2018.1477864DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6060375PMC
November 2018
10 Reads

Stabilized tetraether lipids based particles guided prophyrins photodynamic therapy.

Drug Deliv 2018 Nov;25(1):1526-1536

a Department of Pharmaceutics and Biopharmaceutics , University of Marburg , Marburg , Germany.

Photodynamic therapy (PDT) that involves ergonomically delivered light in the presence of archetypical photosensitizer such as Protoporphyrin IX (PpIX) is a time-honored missile strategy in cancer therapeutics. Yet, the premature release of PpIX is one of the most abundant dilemma encounters the therapeutic outcomes of PDT due to associated toxicity and redistribution to serum proteins. In this study, ultrastable tetraether lipids (TELs) based liposomes were developed. Read More

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http://dx.doi.org/10.1080/10717544.2018.1482970DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6058496PMC
November 2018
7 Reads