7,731 results match your criteria Driving and Neurological Disease

Maturation of the Na,K-ATPase in the Endoplasmic Reticulum in Health and Disease.

J Membr Biol 2021 Jun 10. Epub 2021 Jun 10.

Department of Internal Medicine, Universities of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Justus Liebig University, Klinikstrasse 33, 35392, Giessen, Germany.

The Na,K-ATPase establishes the electrochemical gradient of cells by driving an active exchange of Na and K ions while consuming ATP. The minimal functional transporter consists of a catalytic α-subunit and a β-subunit with chaperon activity. The Na,K-ATPase also functions as a cell adhesion molecule and participates in various intracellular signaling pathways. Read More

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Association of inherited chromosomally integrated human herpesvirus 6 with neurologic symptoms and management after allogeneic hematopoietic cell transplantation.

Transplant Cell Ther 2021 Jun 7. Epub 2021 Jun 7.

Fred Hutchinson Cancer Research Center, Vaccine and Infectious Disease Division, Seattle, WA, USA; Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Seattle, WA, USA. Electronic address:

Background: Reactivation of human herpesvirus 6 (HHV-6) after allogeneic hematopoietic cell transplant (HCT) is associated with neurologic complications, but the impact of donor and/or recipient inherited chromosomally integrated HHV-6 (iciHHV-6) on post-HCT central nervous system (CNS) symptoms, diagnostic and therapeutic interventions is not well understood.

Objective: The aims of the study were 1) to compare the cumulative incidence of CNS symptoms in the first 100 days following allogeneic HCT among patients with donor and/or recipient iciHHV-6 (iciHHV-6) to that of patients with neither donor nor recipient iciHHV-6 (iciHHV-6) and 2) to assess the role of HHV-6 detection in driving potentially unnecessary interventions in iciHHV-6 patients.

Study Design: We performed a retrospective matched cohort study of 87 iciHHV-6 and 174 iciHHV-6 allogeneic HCT recipients. Read More

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The synergy of BET inhibitors with aurora A kinase inhibitors in MYCN-amplified neuroblastoma is heightened with functional TP53.

Neoplasia 2021 Jun 6;23(6):624-633. Epub 2021 Jun 6.

Department of Pediatrics, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, California, USA; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, California, USA. Electronic address:

Amplification of MYCN is a poor prognostic feature in neuroblastoma (NBL) indicating aggressive disease. We and others have shown BET bromodomain inhibitors (BETi) target MYCN indirectly by downregulating its transcription. Here we sought to identify agents that synergize with BETi and to identify biomarkers of resistance. Read More

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Why and how the work of Motor Neurone Disease Associations matters before and during bereavement: a consumer perspective.

Palliat Care Soc Pract 2021 22;15:26323524211009537. Epub 2021 Apr 22.

Department of Neurology, Sir Charles Gairdner Hospital, Perth, WA, Australia.

Background: Studies on the experiences of consumers with Motor Neurone Disease Associations at end of life and bereavement are lacking, and their role and capability within the broader sectors of health and disability are unknown.

Objectives: To ascertain the experiences and views of bereaved motor neurone disease caregivers with Motor Neurone Disease Associations about service gaps and needed improvements before and during bereavement and to propose a model of care that fits with consumer preferences and where Motor Neurone Disease Associations are effective enablers of care.

Methods: A national bereavement survey was facilitated in 2019 by all Motor Neurone Disease Associations in Australia. Read More

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Complete Correction of Brain and Spinal Cord Pathology in Metachromatic Leukodystrophy Mice.

Front Mol Neurosci 2021 21;14:677895. Epub 2021 May 21.

NeuroGenCell, Institut du Cerveau et de la Moelle Épinière, ICM, Inserm U 1127, CNRS UMR 7225, Sorbonne Université, Paris, France.

Metachromatic leukodystrophy (MLD) is a lysosomal storage disorder characterized by accumulation of sulfatides in both glial cells and neurons. MLD results from an inherited deficiency of arylsulfatase A (ARSA) and myelin degeneration in the central and peripheral nervous systems. Currently, no effective treatment is available for the most frequent late infantile (LI) form of MLD after symptom onset. Read More

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On-road driving test performance in veterans: Effects of age, clinical diagnosis and cognitive measures.

J Safety Res 2021 Jun 23;77:40-45. Epub 2021 Feb 23.

Minneapolis Veterans Affairs Health Care System, Minneapolis, MN, United States; Oregon Center for Aging & Technology, Portland, OR, United States; Department of Psychiatry, University of Minnesota, Minneapolis, MN, United States.

Introduction: Veterans are at heightened risk of being in a motor-vehicle crash and many fail on-road driving evaluations, particularly as they age. This may be due in part to the high prevalence of age-associated conditions impacting cognition in this population, including neurodegenerative diseases (e.g. Read More

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Highlighting the protective or degenerative role of AMPK activators in dementia experimental models.

CNS Neurol Disord Drug Targets 2021 May 26. Epub 2021 May 26.

Electrophysiology Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran.

AMP-activated protein kinase (AMPK) is a serine/threonine kinase and a driving or deterrent factor in the development of neurodegenerative diseases and dementia. AMPK affects intracellular proteins like the mammalian target of rapamycin (mTOR). Peroxisome proliferator-activated receptor-γ coactivator 1-α (among others) contributes to a wide range of intracellular activities based on its downstream molecules such as energy balancing (ATP synthesis), extracellular inflammation, cell growth, and neuronal cell death (such as apoptosis, necrosis, and necroptosis). Read More

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Driving effect of BDNF in the spinal dorsal horn on neuropathic pain.

Neurosci Lett 2021 May 19;756:135965. Epub 2021 May 19.

Jiangxi Academy of Medical Sciences, Nanchang, Jiangxi Province, 330006, China. Electronic address:

Neuropathic pain (NP) is caused by direct or indirect damage to the nervous system and is a common symptom of many diseases. The mechanisms underlying the onset and persistence of NP are unclear. Therefore, research concerning these mechanisms has become an important focus in the medical field. Read More

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[Secondary Progressive Multiple Sclerosis].

Brain Nerve 2021 May;73(5):450-457

Department of Neurology, Kansai Medical University Medical Center.

Secondary progressive multiple sclerosis (SPMS) is defined by the slowly progressive deterioration of clinical symptoms independent of relapse, following the early relapsing-remitting disease course. Diagnosis of SPMS is challenging and usually retrospective because of the lack of reliable diagnostic tests. There is also a lack of reliable clinical symptoms other than gait disturbance, which are well evaluated in the clinical setting. Read More

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Talking With Patients and Care Partners About Treatment Goals and Challenges in Early-Stage Alzheimer Disease.

J Clin Psychiatry 2021 05 11;82(3). Epub 2021 May 11.

Indiana University School of Medicine, Indianapolis, Indiana.

Alzheimer disease (AD) requires timely diagnosis and treatment initiation as early as possible to delay further loss of functioning. Clinicians must attempt to answer patients' and care partners' questions about treatment goals and expected challenges. In this webcast, Drs Burke and Apostolova address topics critical to the care of patients with early-stage AD. Read More

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Costs of Epilepsy in Austria: Unemployment as a primary driving factor.

Seizure 2021 Apr 30;89:24-29. Epub 2021 Apr 30.

Klinik Hietzing and Karl Landsteiner Institute for Clinical Epilepsy Research and Cognitive Neurology, Vienna, Austria.

Purpose: Epilepsy is one of the most common chronic neurological disorders, and long-term treatment with antiseizure medication is often central to its management. The costs of antiseizure medication are more evident than other disease-related costs; thus, we assessed the direct and indirect costs of epilepsy focusing on both drug expenditure and other cost-driving factors.

Methods: Outpatient records and questionnaires applied in a tertiary epilepsy centre in Vienna were used in this bottom-up cost-of-illness study to evaluate disease duration, age at onset, epilepsy syndrome, seizure frequency, sex, healthcare utilisation, diagnostic evaluations, antiseizure medication, and occupation. Read More

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α-synuclein aggregates induce c-Abl activation and dopaminergic neuronal loss by a feed-forward redox stress mechanism.

Prog Neurobiol 2021 Jul 2;202:102070. Epub 2021 May 2.

Department of Neurology, University of California San Francisco, United States; Neurology Service, San Francisco Veterans Affairs Health Care System, United States. Electronic address:

Oxidative stress and α-synuclein aggregation both drive neurodegeneration in Parkinson's disease, and the protein kinase c-Abl provides a potential amplifying link between these pathogenic factors. Suppressing interactions between these factors may thus be a viable therapeutic approach for this disorder. To evaluate this possibility, pre-formed α-synuclein fibrils (PFFs) were used to induce α-synuclein aggregation in neuronal cultures. Read More

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A Systematic Review of Urban Navigation Systems for Visually Impaired People.

Sensors (Basel) 2021 Apr 29;21(9). Epub 2021 Apr 29.

School of Computer Science, Technological University Dublin, D07EWV4 Dublin, Ireland.

Blind and Visually impaired people (BVIP) face a range of practical difficulties when undertaking outdoor journeys as pedestrians. Over the past decade, a variety of assistive devices have been researched and developed to help BVIP navigate more safely and independently. In addition, research in overlapping domains are addressing the problem of automatic environment interpretation using computer vision and machine learning, particularly deep learning, approaches. Read More

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Metabolic Dysfunction-Associated Fatty Liver Disease (MAFLD)-A Condition Associated with Heightened Sympathetic Activation.

Int J Mol Sci 2021 Apr 19;22(8). Epub 2021 Apr 19.

Dobney Hypertension Centre, School of Medicine-Royal Perth Hospital Unit, RPH Research Foundation, Faculty of Medicine, Dentistry and Health Sciences, The University of Western Australia, Perth, WA 6000, Australia.

Metabolic dysfunction-associated fatty liver disease (MAFLD) is the most common liver disease affecting a quarter of the global population and is often associated with adverse health outcomes. The increasing prevalence of MAFLD occurs in parallel to that of metabolic syndrome (MetS), which in fact plays a major role in driving the perturbations of cardiometabolic homeostasis. However, the mechanisms underpinning the pathogenesis of MAFLD are incompletely understood. Read More

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Atypical p38 Signaling, Activation, and Implications for Disease.

Int J Mol Sci 2021 Apr 17;22(8). Epub 2021 Apr 17.

Department of Pharmaceutical and Biomedical Sciences, College of Pharmacy, University of Georgia, Athens, GA 30602, USA.

The mitogen-activated protein kinase (MAPK) p38 is an essential family of kinases, regulating responses to environmental stress and inflammation. There is an ever-increasing plethora of physiological and pathophysiological conditions attributed to p38 activity, ranging from cell division and embryonic development to the control of a multitude of diseases including retinal, cardiovascular, and neurodegenerative diseases, diabetes, and cancer. Despite the decades of intense investigation, a viable therapeutic approach to disrupt p38 signaling remains elusive. Read More

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Deciphering Multiple Sclerosis Progression.

Front Neurol 2021 7;12:608491. Epub 2021 Apr 7.

Neuroimmunology Unit, Neurology Department, Hospital Universitari i Politècnic La Fe, Valencia, Spain.

Multiple sclerosis (MS) is primarily an inflammatory and degenerative disease of the central nervous system, triggered by unknown environmental factors in patients with predisposing genetic risk profiles. The prevention of neurological disability is one of the essential goals to be achieved in a patient with MS. However, the pathogenic mechanisms driving the progressive phase of the disease remain unknown. Read More

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Medications and risk of motor vehicle collision responsibility in British Columbia, Canada: a population-based case-control study.

Lancet Public Health 2021 Jun 20;6(6):e374-e385. Epub 2021 Apr 20.

Department of Ophthalmology, Medicine and Pharmacology, The University of British Columbia, Vancouver, BC, Canada.

Background: Many medications impair driving skills yet their influence on collision risk remains uncertain. We aimed to systematically investigate the risk of collision responsibility associated with common classes of prescription medications.

Methods: In this population-based case-control study we analysed linked driving and health records in British Columbia, Canada from Jan 1, 1997, to Dec 31, 2016. Read More

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Impacts of a Pressure Challenge on Cerebral Critical Closing Pressure and Effective Cerebral Perfusion Pressure in Patients with Traumatic Brain Injury.

Acta Neurochir Suppl 2021 ;131:11-16

Intensive Care Unit, Hospital de Clinicas, Universidad de la Republica, Montevideo, Uruguay.

Introduction: Cerebral critical closing pressure (CrCP) comprises intracranial pressure (ICP) and arteriolar wall tension (WT). It is the arterial blood pressure (ABP) at which small vessels close and circulation stops. We hypothesized that the increase in WT secondary to a systemic hypertensive challenge would lead to an increase in CrCP and that the "effective" cerebral perfusion pressure (CPPeff; calculated as ABP - CrCP) would give more complete information than the "conventional" cerebral perfusion pressure (CPP; calculated as ABP - ICP). Read More

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Involvement of cytotoxic Eomes-expressing CD4 T cells in secondary progressive multiple sclerosis.

Proc Natl Acad Sci U S A 2021 Mar;118(11)

Department of Immunology, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Tokyo, 187-8502 Japan;

Multiple sclerosis (MS), a putative autoimmune disease of the central nervous system (CNS), commonly presents as relapsing-remitting MS (RRMS), characterized by recurrent episodes of peripheral disabling symptoms resulting from inflammatory CNS damage. Many RRMS patients transition to a chronic disease course with progressive neurological dysfunctions (secondary progressive MS, SPMS), with the progression rate varying between patients and over time. SPMS pathogenesis is now linked to immune-cell-mediated processes, although the mechanisms driving SPMS transition and progression remain elusive, and SPMS lacks biomarkers and effective treatments. Read More

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Vision, attention, and driving.

Handb Clin Neurol 2021 ;178:337-360

Department of Neurological Sciences, University of Nebraska Medical Center, Omaha, NE, United States. Electronic address:

Safe driving demands the coordination of multiple sensory and cognitive functions, such as vision and attention. Patients with neurologic or ophthalmic disease are exposed to selective pathophysiologic insults to driving-critical systems, placing them at a higher risk for unsafe driving and restricted driving privileges. Here, we evaluate how vision and attention contribute to unsafe driving across different patient populations. Read More

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January 2021

Neurogenic Obesity-Induced Insulin Resistance and Type 2 Diabetes Mellitus in Chronic Spinal Cord Injury.

Top Spinal Cord Inj Rehabil 2021 ;27(1):36-56

Department of Physical Medicine and Rehabilitation, University of Miami Miller School of Medicine, Miami, Florida.

The population with SCI is at a significant risk for both insulin resistance and type 2 diabetes mellitus (T2DM) secondary to neurogenic obesity. The prevalence of insulin resistance and T2DM in persons with SCI suggests that disorders of carbohydrate metabolism are at epidemic proportions within the population. However, the true frequency of such disorders may be underestimated because biomarkers of insulin resistance and T2DM used from the population without SCI remain nonspecific and may in fact fail to identify true cases that would benefit from intervention. Read More

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Insight into Inhibitory Mechanism of PDE4D by Dietary Polyphenols Using Molecular Dynamics Simulations and Free Energy Calculations.

Biomolecules 2021 Mar 23;11(3). Epub 2021 Mar 23.

Faculty of Chemistry and Chemical Engineering, University of Maribor, Smetanova 17, SI-2000 Maribor, Slovenia.

Phosphodiesterase 4 (PDE4), mainly present in immune, epithelial, and brain cells, represents a family of key enzymes for the degradation of cyclic adenosine monophosphate (cAMP), which modulates inflammatory response. In recent years, the inhibition of PDE4 has been proven to be an effective therapeutic strategy for the treatment of neurological disorders. PDE4D constitutes a high-interest therapeutic target primarily for the treatment of Alzheimer's disease, as it is highly involved in neuroinflammation, learning ability, and memory dysfunctions. Read More

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An Analysis of the Neurological and Molecular Alterations Underlying the Pathogenesis of Alzheimer's Disease.

Cells 2021 Mar 4;10(3). Epub 2021 Mar 4.

Department of Biological Sciences, University of Texas at Dallas, Campbell Road, Mail Stop RL11, 800 W, Richardson, TX 75080, USA.

Alzheimer's disease (AD) is a neurodegenerative disorder characterized by amyloid beta (Aβ) plaques, neurofibrillary tangles, and neuronal loss. Unfortunately, despite decades of studies being performed on these histological alterations, there is no effective treatment or cure for AD. Identifying the molecular characteristics of the disease is imperative to understanding the pathogenesis of AD. Read More

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The 'Jekyll and Hyde' of Gluconeogenesis: Early Life Adversity, Later Life Stress, and Metabolic Disturbances.

Int J Mol Sci 2021 Mar 25;22(7). Epub 2021 Mar 25.

Immune Endocrine and Epigenetics Research Group, Department of Infection and Immunity, Luxembourg Institute of Health (LIH), L-4354 Esch-sur-Alzette, Luxembourg.

The physiological response to a psychological stressor broadly impacts energy metabolism. Inversely, changes in energy availability affect the physiological response to the stressor in terms of hypothalamus, pituitary adrenal axis (HPA), and sympathetic nervous system activation. Glucocorticoids, the endpoint of the HPA axis, are critical checkpoints in endocrine control of energy homeostasis and have been linked to metabolic diseases including obesity, insulin resistance, and type 2 diabetes. Read More

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Microglial Heterogeneity and Its Potential Role in Driving Phenotypic Diversity of Alzheimer's Disease.

Int J Mol Sci 2021 Mar 9;22(5). Epub 2021 Mar 9.

Neurology 5 and Neuropathology Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, 20133 Milan, Italy.

Alzheimer's disease (AD) is increasingly recognized as a highly heterogeneous disorder occurring under distinct clinical and neuropathological phenotypes. Despite the molecular determinants of such variability not being well defined yet, microglial cells may play a key role in this process by releasing distinct pro- and/or anti-inflammatory cytokines, potentially affecting the expression of the disease. We carried out a neuropathological and biochemical analysis on a series of AD brain samples, gathering evidence about the heterogeneous involvement of microglia in AD. Read More

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Muscle Diversity, Heterogeneity, and Gradients: Learning from Sarcoglycanopathies.

Int J Mol Sci 2021 Mar 2;22(5). Epub 2021 Mar 2.

Department of AHFMO, University of Rome "la Sapienza", Via A. Scarpa 14, 00161 Rome, Italy.

Skeletal muscle, the most abundant tissue in the body, is heterogeneous. This heterogeneity forms the basis of muscle diversity, which is reflected in the specialized functions of muscles in different parts of the body. However, these different parts are not always clearly delimitated, and this often gives rise to gradients within the same muscle and even across the body. Read More

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Association between Sarcopenia, Its Defining Indices, and Driving Cessation in Older Adults.

J Nutr Health Aging 2021 ;25(4):462-466

Takehiko Doi, Department of Preventive Gerontology, Center for Gerontology and Social Science, National Center for Geriatrics and Gerontology, 7-430, Morioka, Obu, Aichi 474-8511, Japan, Tel: +81-562-44-5651, E-mail:

Objectives: Driving a car is essential for older adults to support their activities of daily living and maintain their quality of life. However, physical function - which often declines with age - is a key factor to determine whether older adults can continue driving safely. As such, we sought to examine the association between sarcopenia and driving cessation in older adults. Read More

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Dissolving the Complex Role Aggregation Plays in Neurodegenerative Disease.

Mov Disord 2021 05 23;36(5):1061-1069. Epub 2021 Mar 23.

Departments of Neurology, Pathology and Cell Biology, Columbia University, New York, New York, USA.

Prominent neuropathological hallmarks of many adult-onset neurodegenerative diseases include the deposition and accumulation of misfolded proteins or conformers; however, their role in pathogenesis has remained unclear. This is in part due to the deceptive simplicity of the question and our limited understanding of how protein homeostasis is maintained in the compartmentalized cells of the central nervous system, especially in the context of the adult brain. Building on studies from simple cell-based systems and invertebrate animals, we recently identified a protein central to the specific and selective turnover of aggregated proteins in the adult brain, the autophagy-linked FYVE protein (Alfy)/Wdfy3. Read More

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Social aspects of life in patients with functional seizures: Closing the gap in the biopsychosocial formulation.

Epilepsy Behav 2021 04 16;117:107903. Epub 2021 Mar 16.

Laboratory of Clinical Neurophysiology, Department of Psychiatry, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (HCFMUSP), São Paulo, Brazil. Electronic address:

The human, as a biological system, is an open system embedded within larger systems -including the family, culture, and socio-political environment. In this context, a patient with functional seizures (FS) is embedded in relationships, educational/professional institutions, culture, and society. Both connection to these broader systems and the quality of these connections, as well as the soundness of each system in and of itself, influence the health and well-being of patients in positive or negative ways. Read More

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[How and when to stop antiepileptic drugs?]

Rev Prat 2020 Oct;70(8):819-823

AP-HP, hôpital de La Pitié-Salpêtrière, unité d'épilepsie et centre de référence des épilepsies rares, Paris, France.

How and when to stop antiepileptic drugs? Antiepileptic drugs withdrawal can be considered in seizure-free patients with a 2-year minimum complete remission. Risk of seizure recurrence, which is related both to the epilepsy syndrome and individual characteristics, must be evaluated and may rely on the use of a computer-based risk calculator. Identifying epileptic abnormalities on EEG and cortical lesions on brain MRI could lead to reconsider drug discontinuation. Read More

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October 2020