8,553 results match your criteria Driving and Neurological Disease

Corrigendum: Analysis of Pathogenic Pseudoexons Reveals Novel Mechanisms Driving Cryptic Splicing.

Front Genet 2022 9;13:943044. Epub 2022 Jun 9.

Centre for Molecular Medicine and Innovative Therapeutics, Health Futures Institute, Murdoch University, Perth, WA, Australia.

[This corrects the article DOI: 10.3389/fgene.2021. Read More

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A Wearable Assistive Device for Blind Pedestrians Using Real-Time Object Detection and Tactile Presentation.

Sensors (Basel) 2022 Jun 16;22(12). Epub 2022 Jun 16.

Department of Pure and Applied Physics, Faculty of Science and Engineering, Waseda University, Tokyo 169-8555, Japan.

Nowadays, improving the traffic safety of visually impaired people is a topic of widespread concern. To help avoid the risks and hazards of road traffic in their daily life, we propose a wearable device using object detection techniques and a novel tactile display made from shape-memory alloy (SMA) actuators. After detecting obstacles in real-time, the tactile display attached to a user's hands presents different tactile sensations to show the position of the obstacles. Read More

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Efficient Viral Transduction in Fetal and Adult Human Inner Ear Explants with AAV9-PHP.B Vectors.

Biomolecules 2022 Jun 10;12(6). Epub 2022 Jun 10.

Department of Otorhinolaryngology and Head & Neck Surgery, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands.

Numerous studies have shown the recovery of auditory function in mouse models of genetic hearing loss following AAV gene therapy, yet translation to the clinic has not yet been demonstrated. One limitation has been the lack of human inner ear cell lines or tissues for validating viral gene therapies. Cultured human inner ear tissue could help confirm viral tropism and efficacy for driving exogenous gene expression in targeted cell types, establish promoter efficacy and perhaps selectivity for targeted cells, confirm the expression of therapeutic constructs and the subcellular localization of therapeutic proteins, and address the potential cellular toxicity of vectors or exogenous constructs. Read More

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Sex-specific differences in zebrafish brains.

Biol Sex Differ 2022 Jun 17;13(1):31. Epub 2022 Jun 17.

Biology, The Life Science Center, School of Science and Technology, Örebro University, 70182, Örebro, Sweden.

In this systematic review, we highlight the differences between the male and female zebrafish brains to understand their differentiation and their use in studying sex-specific neurological diseases. Male and female brains display subtle differences at the cellular level which may be important in driving sex-specific signaling. Sex differences in the brain have been observed in humans as well as in non-human species. Read More

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Multiple primary malignances managed with surgical excision: a case report with next generation sequencing analysis.

Mol Biol Rep 2022 Jun 17. Epub 2022 Jun 17.

Department of General Surgery and Medical-Surgical Specialties, University of Catania, 95123, Catania, Italy.

Background: Multiple primary malignancies (MPM) are defined as tumors originating in the same individual without any correlation between them. In addition to morphological and immunohistochemical analyses, sensitive DNA sequencing methods such as next generation sequencing (NGS) may help to discriminate the common or different genetic alterations driving each malignancy, to better diagnose these uncommon cases.

Methods And Results: Here we report the case of a man who developed a poorly differentiated gastric adenocarcinoma invading the pancreas followed, two years later, by a colorectal cancer involving also the kidney and the diaphragm. Read More

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Factors related to healthcare costs of road traffic accidents in Bucaramanga, Colombia.

Rev Saude Publica 2022 13;56:47. Epub 2022 Jun 13.

Dirección de Transito de Bucaramanga. Subdirección Técnica. Bucaramanga, Santander, Colombia.

Objective: To determine the factors related to overall healthcare costs of road traffic accidents in Bucaramanga, Colombia.

Methods: A descriptive cross-sectional study was conducted through the analysis of road traffic accident records that took place in 2019 in Bucaramanga, Colombia. Cost quartiles in dollars were compared using Pearson's chi-squared and Fisher's exact tests. Read More

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Clinical Features of Children with COVID-19 Infection: Single-Center Experience.

Eurasian J Med 2022 Jun;54(2):173-180

Division of Pediatric Gastroenterology, Department of Pediatrics, Çukurova University Faculty of Medicine, Adana, Turkey.

Objective: Compared to adult studies, there are few epidemiological and clinical reports on coronavirus disease 2019 in children. We aimed to present the demographic, epidemiological, and clinical findings of hospitalized pediatric coronavirus disease 2019 patients.

Materials And Methods: Patients aged 0-18 years who were hospitalized between March and July 2020 due to severe acute respiratory syndrome coronavirus 2 infection were evaluated retrospectively. Read More

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Mechanisms Driving the Emergence of Neuronal Hyperexcitability in Fragile X Syndrome.

Int J Mol Sci 2022 Jun 5;23(11). Epub 2022 Jun 5.

Department of Cell Biology, Emory University School of Medicine, Atlanta, GA 30322, USA.

Hyperexcitability is a shared neurophysiological phenotype across various genetic neurodevelopmental disorders, including Fragile X syndrome (FXS). Several patient symptoms are associated with hyperexcitability, but a puzzling feature is that their onset is often delayed until their second and third year of life. It remains unclear how and why hyperexcitability emerges in neurodevelopmental disorders. Read More

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Mu and Delta Opioid Receptor Targeting Reduces Connexin 43-Based Heterocellular Coupling during Neuropathic Pain.

Int J Mol Sci 2022 May 24;23(11). Epub 2022 May 24.

Section of Pharmacology and Toxicology, Department of Drug and Health Sciences, University of Catania, 95123 Catania, Italy.

Chronic neuropathic pain emerges from either central or peripheral lesions inducing spontaneous or amplified responses to non-noxious stimuli. Despite different pharmacological approaches to treat such a chronic disease, neuropathic pain still represents an unmet clinical need, due to long-term therapeutic regimens and severe side effects that limit application of currently available drugs. A critical phenomenon involved in central sensitization is the exchange of signalling molecules and cytokines, between glia and neurons, driving the chronicization process. Read More

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The pathogenesis of neurologic symptoms of the postacute sequelae of severe acute respiratory syndrome coronavirus 2 infection.

Curr Opin Neurol 2022 06;35(3):384-391

Section of Infections of the Nervous System, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA.

Purpose Of Review: The coronavirus disease 2019 (COVID) pandemic has resulted in significant mortality and morbidity globally. Patients who survive infection may develop continuing disease collectively known as the postacute sequelae of severe acute respiratory syndrome coronavirus 2 infection (PASC), which includes neurologic symptoms especially fatigue and cognitive impairment. The pathogenic mechanisms driving PASC are unknown although a postinfectious process, persistent infection, or lasting pathophysiological changes that occur during acute infection are all suspected to contribute. Read More

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Cycling multisensory changes in migraine: more than a headache.

Curr Opin Neurol 2022 06;35(3):367-372

Department of Systems Neuroscience, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Purpose Of Review: Research on migraine usually focuses on the headache; however, accumulating evidence suggests that migraine not only changes the somatosensory system for nociception (pain), but also the other modalities of perception, such as visual, auditory or tactile sense. More importantly, the multisensory changes exist beyond the headache (ictal) phase of migraine and show cyclic changes, suggesting a central generator driving the multiple sensory changes across different migraine phases. This review summarizes the latest studies that explored the cyclic sensory changes of migraine. Read More

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Glycation of α-synuclein hampers its binding to synaptic-like vesicles and its driving effect on their fusion.

Cell Mol Life Sci 2022 Jun 4;79(6):342. Epub 2022 Jun 4.

Departament de Química, Institut Universitari d'Investigació en Ciències de la Salut (IUNICS), Institut de Recerca en Ciències de la Salut (IdISBa), Universitat de les Illes Balears, Ed. Mateu Orfila i Rotger, Ctra. Valldemossa km 7.5, 07122, Palma, Spain.

Parkinson's disease (PD) is one of the most prevalent neurodegenerative disorders affecting the worldwide population. One of its hallmarks is the intraneuronal accumulation of insoluble Lewy bodies (LBs), which cause the death of dopaminergic neurons. α-Synuclein (αS) is the main component of these LBs and in them, it commonly contains non-enzymatic post-translational modifications, such as those resulting from its reaction with reactive carbonyl species arising as side products of the intraneuronal glycolysis (mainly methylglyoxal). Read More

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Hiding in plain sight: The magnitude of unused disease modifying therapies in multiple sclerosis and strategies for reducing the economic burden of care.

Mult Scler Relat Disord 2022 Jul 27;63:103920. Epub 2022 May 27.

Department of Neurology, Neuroinnovation Program, Multiple Sclerosis & Neuroimmunology Imaging Program, UT Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390-8806, USA.

Background: The rising costs associated with multiple sclerosis (MS) disease modifying therapies (DMTs) creates challenges for patients and the healthcare system in the United States (U.S.). Read More

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Examining demographic, work, and sleep characteristics among older South Asian American yellow taxi drivers in New York City: A brief report.

Sleep Med 2022 Aug 30;96:128-131. Epub 2022 Apr 30.

Department of Population Health, Section for Health Equity, NYU Grossman School of Medicine, New York, NY, USA.

Objectives: This exploratory study examines workplace factors, sleep, sleep disorders, and safety among older (age 50 years and above) yellow taxi drivers in New York City (NYC) of South Asian descent.

Methods: Using street intercept methods, quantitative data was collected among yellow taxi drivers in NYC (n = 27) from January-March 2020.

Results: Among drivers, higher than normal sleepiness was identified in 33%, sleeping fewer than 7 hours on worknights work nights was reported by 52%, and 37% were at high risk for obstructive sleep apnea (OSA). Read More

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Rocuronium versus saline for effective facemask ventilation during anesthesia induction: a double-blinded randomized placebo-controlled trial.

BMC Anesthesiol 2022 Jun 3;22(1):173. Epub 2022 Jun 3.

Department of Anesthesiology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-Ku, Chiba, 260-8670, Japan.

Background: Mask ventilation progressively improves after loss of consciousness during anesthesia induction possibly due to progression of muscle paralysis. This double-blinded randomized placebo-controlled study aimed to test a hypothesis that muscle paralysis improves mask ventilation during anesthesia induction.

Methods: Forty-four adults patients including moderate to severe obstructive sleep apnea undergoing scheduled surgeries under elective general anesthesia participated in this study. Read More

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PDGF signaling inhibits mitophagy in glioblastoma stem cells through N-methyladenosine.

Dev Cell 2022 Jun 3;57(12):1466-1481.e6. Epub 2022 Jun 3.

Hillman Cancer Center, University of Pittsburgh Medical Center, Pittsburgh, PA 15232, USA; Division of Regenerative Medicine, School of Medicine, University of California San Diego, CA 92037, USA; Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15232, USA. Electronic address:

Dysregulated growth factor receptor pathways, RNA modifications, and metabolism each promote tumor heterogeneity. Here, we demonstrate that platelet-derived growth factor (PDGF) signaling induces N-methyladenosine (mA) accumulation in glioblastoma (GBM) stem cells (GSCs) to regulate mitophagy. PDGF ligands stimulate early growth response 1 (EGR1) transcription to induce methyltransferase-like 3 (METTL3) to promote GSC proliferation and self-renewal. Read More

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The Role of Kynurenine Pathway and NAD Metabolism in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

Aging Dis 2022 Jun 1;13(3):698-711. Epub 2022 Jun 1.

1Neuroinflammation Group, Faculty of Medicine and Health Sciences, Macquarie University, NSW, Australia.

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a serious, complex, and highly debilitating long-term illness. People with ME/CFS are typically unable to carry out their routine activities. Key hallmarks of the disease are neurological and gastrointestinal impairments accompanied by pervasive malaise that is exacerbated after physical and/or mental activity. Read More

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Glioma progression is shaped by genetic evolution and microenvironment interactions.

Cell 2022 Jun 31;185(12):2184-2199.e16. Epub 2022 May 31.

Case Western Reserve University School of Medicine and University Hospitals of Cleveland, Cleveland, OH, USA; Center for Biomedical Informatics and Information Technology & Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.

The factors driving therapy resistance in diffuse glioma remain poorly understood. To identify treatment-associated cellular and genetic changes, we analyzed RNA and/or DNA sequencing data from the temporally separated tumor pairs of 304 adult patients with isocitrate dehydrogenase (IDH)-wild-type and IDH-mutant glioma. Tumors recurred in distinct manners that were dependent on IDH mutation status and attributable to changes in histological feature composition, somatic alterations, and microenvironment interactions. Read More

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Uncoupling Proteins as Therapeutic Targets for Neurodegenerative Diseases.

Int J Mol Sci 2022 May 18;23(10). Epub 2022 May 18.

Department of Neural and Behavioral Sciences, Penn State College of Medicine, 500 University Drive, Hershey, PA 17033, USA.

Most of the major retinal degenerative diseases are associated with significant levels of oxidative stress. One of the major sources contributing to the overall level of stress is the reactive oxygen species (ROS) generated by mitochondria. The driving force for ROS production is the proton gradient across the inner mitochondrial membrane. Read More

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Impact of Raptor and Rictor Deletion on Hippocampal Pathology Following Status Epilepticus.

J Mol Neurosci 2022 Jun 27;72(6):1243-1258. Epub 2022 May 27.

Department of Anesthesia, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, CincinnatiCincinnati, OH, ML200145229, USA.

Neuronal hyperactivation of the mTOR signaling pathway may play a role in driving the pathological sequelae that follow status epilepticus. Animal studies using pharmacological tools provide support for this hypothesis, however, systemic inhibition of mTOR-a growth pathway active in every mammalian cell-limits conclusions on cell type specificity. To circumvent the limitations of pharmacological approaches, we developed a viral/genetic strategy to delete Raptor or Rictor, inhibiting mTORC1 or mTORC2, respectively, from excitatory hippocampal neurons after status epilepticus in mice. Read More

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Obstructive sleep apnea and road traffic accidents: a Danish nationwide cohort study.

Sleep Med 2022 Aug 13;96:64-69. Epub 2022 Apr 13.

Department of Otorhinolaryngology, Head and Neck Surgery, Aarhus University Hospital Skejby, Aarhus, Denmark.

Study Objectives: In this nationwide study, we investigate the risk and severity of all road traffic accidents in patients with obstructive sleep apnea (OSA).

Methods: We used the unique Danish registries to identify all Danish citizens receiving a diagnosis of OSA between 1995 and 2015. As a reference cohort, we randomly selected 10 sex- and age-matched citizens for each patient. Read More

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Sugar and stops in drivers with insulin-dependent type 1 diabetes.

Accid Anal Prev 2022 Aug 20;173:106692. Epub 2022 May 20.

Department of Neurological Sciences, University of Nebraska Medical Center, Omaha, United States.

Background: Diabetes is a major public health challenge, affecting millions of people worldwide. Abnormal physiology in diabetes, particularly hypoglycemia, can cause driver impairments that affect safe driving. While diabetes driver safety has been previously researched, few studies link real-time physiologic changes in drivers with diabetes to objective real-world driver safety, particularly at high-risk areas like intersections. Read More

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Fatty Acid Metabolism and T Cells in Multiple Sclerosis.

Front Immunol 2022 4;13:869197. Epub 2022 May 4.

Faculty of Medicine, Imperial College London, London, United Kingdom.

Cellular metabolic remodeling is intrinsically linked to the development, activation, differentiation, function, and survival of T cells. T cells transition from a catabolic, naïve state to an anabolic effector state upon T cell activation. Subsequently, specialization of T cells into T helper (Th) subsets, including regulatory T cells (T), requires fine-tuning of metabolic programs that better support and optimize T cell functions for that particular environment. Read More

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Eligibility to drive and neurology: the how and the why.

Pract Neurol 2022 May 17. Epub 2022 May 17.

Drivers Medical Group, DVLA, Swansea, UK.

Driving is an integral part of adult life and losing a driving licence is potentially a major problem. Many neurological conditions may impact on driving, either by increasing the risk of a sudden disabling event or by affecting cognition, vision, reaction speed, motor coordination, peripheral sensation or visuospatial processing. In the UK, the Drivers Medical Group of the Driver and Vehicle Licensing Agency (DVLA) decides whether an individual's medical condition meets the appropriate standards for driving. Read More

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The vicious cycle governing the brain-immune system relationship in neurodegenerative diseases.

Curr Opin Immunol 2022 Jun 13;76:102182. Epub 2022 May 13.

Department of Brain Sciences, Weizmann Institute of Science, Rehovot, Israel.

For decades, neurodegenerative diseases were thought to be caused by the accumulation of toxic compounds, exacerbated by local inflammation, which together lead to neuronal loss and cognitive impairment . An additional factor that was long overlooked , is the role of the systemic immune system, which provides a defense mechanism against internal and external intruders in all bodily tissues. The evolving understanding of the life-long cross-talk between the CNS and the immune system led to an awareness of the function of systemic adaptive immunity in containing emerging destructive factors within the brain. Read More

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Change blindness in simulated driving in individuals with homonymous visual field loss.

Cogn Res Princ Implic 2022 05 15;7(1):44. Epub 2022 May 15.

Schepens Eye Research Institute of Massachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical School, 20 Staniford St., Boston, MA, 02114, USA.

Individuals with homonymous visual field loss (HVFL) fail to perceive visual information that falls within the blind portions of their visual field. This places additional burden on memory to represent information in their blind visual field, which may make visual changes in the scene more difficult to detect. Failing to detect changes could have serious implications in the context of driving. Read More

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Path analysis of biomarkers for cognitive decline in early Parkinson's disease.

PLoS One 2022 13;17(5):e0268379. Epub 2022 May 13.

School of Health and Behavioural Science, University of the Sunshine Coast, Sippy Downs, Queensland, Australia.

Clinical and biochemical diversity of Parkinson's disease (PD) and numerous demographic, clinical, and pathological measures influencing cognitive function and its decline in PD create problems with the determination of effects of individual measures on cognition in PD. This is particularly the case where these measures significantly interrelate with each other producing intricate networks of direct and indirect effects on cognition. Here, we use generalized structural equation modelling (GSEM) to identify and characterize significant paths for direct and indirect effects of 14 baseline measures on global cognition in PD at baseline and at 4 years later. Read More

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Evaluation After a First Seizure in Adults.

Am Fam Physician 2022 May;105(5):507-513

Rush University, Chicago, IL, USA.

Seizures are transient signs and symptoms of abnormal, excessive, or synchronous neuronal activity in the brain. Up to 10% of adults have a seizure during their lifetime, with increasing incidence in people older than 55 years. One-third of people have a recurrent seizure within one year of an initial unprovoked seizure. Read More

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Glymphatic System Dysfunction in Central Nervous System Diseases and Mood Disorders.

Front Aging Neurosci 2022 25;14:873697. Epub 2022 Apr 25.

Department of Forensic Analytical Toxicology, School of Forensic Medicine, China Medical University, Shenyang, China.

The glymphatic system, a recently discovered macroscopic waste removal system in the brain, has many unknown aspects, especially its driving forces and relationship with sleep, and thus further explorations of the relationship between the glymphatic system and a variety of possible related diseases are urgently needed. Here, we focus on the progress in current research on the role of the glymphatic system in several common central nervous system diseases and mood disorders, discuss the structural and functional abnormalities of the glymphatic system which may occur before or during the pathophysiological progress and the possible underlying mechanisms. We emphasize the relationship between sleep and the glymphatic system under pathological conditions and summarize the common imaging techniques for the glymphatic system currently available. Read More

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Holistic processing of gaze cues during interocular suppression.

Sci Rep 2022 05 11;12(1):7717. Epub 2022 May 11.

School of Psychology, Western Sydney University, Penrith, NSW, Australia.

Direct eye contact is preferentially processed over averted gaze and has been shown to gain privileged access to conscious awareness during interocular suppression. This advantage might be driven by local features associated with direct gaze, such as the amount of visible sclera. Alternatively, a holistic representation of gaze direction, which depends on the integration of head and eye information, might drive the effects. Read More

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