6,489 results match your criteria Driving and Neurological Disease


Cognitive Fitness to Drive in Huntington's Disease: Assessing the Clinical Utility of DriveSafe DriveAware.

J Huntingtons Dis 2019 ;8(1):87-95

Calvary Health Care Bethlehem, Statewide Progressive Neurological Disease Service, Caulfield South, VIC, Australia.

Background: DriveSafe DriveAware (DSDA) has been validated as an off-road screening tool for predicting on-road driving performance in clinical populations, but its utility in people with Huntington's disease (HD) is unknown.

Objective: Our aim was to evaluate the utility of DSDA in people with HD by demonstrating sensitivity of DSDA scores to HD progression and exploring associations between DSDA performance and cognitive functions that are essential to driving and impaired in people with HD.

Methods: We administered the iPad application version of DSDA to 26 pre-symptomatic and symptomatic participants with HD. Read More

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http://dx.doi.org/10.3233/JHD-180323DOI Listing
January 2019
1 Read

Tau and TDP-43 proteinopathies: kindred pathologic cascades and genetic pleiotropy.

Lab Invest 2019 Feb 11. Epub 2019 Feb 11.

University of Kentucky College of Medicine, Lexington, KY, USA.

We review the literature on Tau and TDP-43 proteinopathies in aged human brains and the relevant underlying pathogenetic cascades. Complex interacting pathways are implicated in Alzheimer's disease and related dementias (ADRD), wherein multiple proteins tend to misfold in a manner that is "reactive," but, subsequently, each proteinopathy may contribute strongly to the clinical symptoms. Tau proteinopathy exists in brains of individuals across a broad spectrum of primary underlying conditions-e. Read More

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http://dx.doi.org/10.1038/s41374-019-0196-yDOI Listing
February 2019
2 Reads

Development and Implementation of a Multi-Disciplinary Technology Enhanced Care Pathway for Youth and Adults with Concussion.

J Vis Exp 2019 Jan 20(143). Epub 2019 Jan 20.

Department of Biomedical Engineering, Cleveland Clinic Foundation; Concussion Center, Cleveland Clinic Foundation.

The evidence-informed standardization of care along disease lines is recommended to improve outcomes and reduce healthcare costs. The aim of this project is to 1) describe the development and implementation of the Concussion Carepath, 2) demonstrate the process of integrating technology in the form of a mobile application to enable the carepath and guide clinical decision-making, and 3) present data on the utility of the C3 app in facilitating decision-making throughout the injury recovery process. A multi-disciplinary team of experts in concussion care was formed to develop an evidence-informed algorithm, outlining best practices for the clinical management of concussion along three phases of recovery - acute, subacute, and post-concussive. Read More

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https://www.jove.com/video/58962/development-implementation-
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http://dx.doi.org/10.3791/58962DOI Listing
January 2019
3 Reads

Factors interfering with parenthood decision-making in an Italian sample of people with multiple sclerosis: an exploratory online survey.

J Neurol 2019 Jan 16. Epub 2019 Jan 16.

First Division of Neurology, University of Campania Luigi Vanvitelli, Piazza Miraglia, 2, 80138, Naples, Italy.

Background: Little is known about the influence of multiple sclerosis (MS) diagnosis on parenthood attitude in people with MS (pwMS).

Objective: To investigate the impact of diagnosis, clinical features and external disease-related influences on parenthood decision-making in Italian pwMS.

Methods: A web-based survey was posted on SMsocialnetwork. Read More

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http://dx.doi.org/10.1007/s00415-019-09193-4DOI Listing
January 2019

Sympathetic nervous system in age-related cardiovascular dysfunction: Pathophysiology and therapeutic perspective.

Int J Biochem Cell Biol 2019 Mar 9;108:29-33. Epub 2019 Jan 9.

Center for Translational Medicine and Department of Pharmacology, Lewis Katz School of Medicine, Temple University, Philadelphia, USA. Electronic address:

Cardiovascular diseases such as heart failure and metabolic syndrome have high prevalence in the elderly population and are leading causes of death, disability, hospitalization, driving high healthcare costs worldwide. To reduce this social and economic burden there is urgency to find effective therapeutic targets. Several studies have linked the dysfunction of the Sympathetic Nervous System and β-adrenergic receptor signaling with the pathogenesis of age-related cardiovascular diseases. Read More

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http://dx.doi.org/10.1016/j.biocel.2019.01.004DOI Listing

When Is It Safe to Drive after Mild Traumatic Brain Injury/Sports-related Concussion?

Curr Sports Med Rep 2019 Jan;18(1):17-19

Department of Family and Community Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM.

Driving an automobile has inherent danger, and driving after mild traumatic brain injury (mTBI)/sports-related concussion (SRC) can make this task even more hazardous. There is evidence to suggest that restriction from driving for the first 24 to 48 h after mTBI/SRC is probably reasonable. However, after the first 48 h have passed, there is insufficient evidence to make a recommendation regarding return to driving. Read More

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http://dx.doi.org/10.1249/JSR.0000000000000558DOI Listing
January 2019
2 Reads

Regulation of P2X7 receptor expression and function in the brain.

Brain Res Bull 2018 Dec 26. Epub 2018 Dec 26.

Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin, Ireland; FutureNeuro Research Centre, Dublin, Ireland.

Because of its prominent role in driving inflammatory processes, the ATP-gated purinergic P2X7 receptor has attracted much attention over the past decade as a potential therapeutic target for numerous human conditions, particularly diseases of the central nervous system, including neurodegenerative diseases (e.g. Alzheimer's and Huntington's disease), psychiatric disorders (e. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03619230183073
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http://dx.doi.org/10.1016/j.brainresbull.2018.12.008DOI Listing
December 2018
9 Reads

Enhanced astrocyte responses are driven by a genetic risk allele associated with multiple sclerosis.

Nat Commun 2018 12 17;9(1):5337. Epub 2018 Dec 17.

Department of Neurology, Yale School of Medicine, New Haven, CT, 06511, USA.

Epigenetic annotation studies of genetic risk variants for multiple sclerosis (MS) implicate dysfunctional lymphocytes in MS susceptibility; however, the role of central nervous system (CNS) cells remains unclear. We investigated the effect of the risk variant, rs7665090, located near NFKB1, on astrocytes. We demonstrated that chromatin is accessible at the risk locus, a prerequisite for its impact on astroglial function. Read More

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http://dx.doi.org/10.1038/s41467-018-07785-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6297228PMC
December 2018
1 Read

Standing Tall: Feasibility of a Modified Ride-On Car That Encourages Standing.

Pediatr Phys Ther 2019 01;31(1):E6-E13

Social Mobility Lab (Drs Logan and Catena and Mss Hospodar, Yohn, and Govindan), College of Public Health and Human Sciences, Oregon State University, Corvallis, Oregon; Go Baby Go Lab (Ms Sabet), College of Health Sciences, Cleveland State University, Cleveland, Ohio; Pediatric Mobility Lab and Design Studio (Dr Galloway), Department of Physical Therapy and Biomechanics and Movement Sciences Program, University of Delaware, Newark, Delaware.

Purpose: The purpose of this study was to determine the feasibility of infants with Down syndrome to use a modified ride-on car with seated and standing modes.

Methods: Participants included 4 infants with Down syndrome. Families were asked to provide at least 8 minutes of modified ride-on car driving per day, at least 5 times per week throughout the 9-month intervention. Read More

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http://dx.doi.org/10.1097/PEP.0000000000000568DOI Listing
January 2019
10 Reads

Molecular Mechanisms Directing Spine Outgrowth and Synaptic Partner Selection in .

J Exp Neurosci 2018 2;12:1179069518816088. Epub 2018 Dec 2.

Department of Neurobiology, University of Massachusetts Medical School, Worcester, MA, USA.

The development of the nervous system requires precise outgrowth, extension, and wiring of both axons and dendrites to generate properly functioning neural circuits. The molecular mechanisms that shape neurite development, in particular dendritic development, remain incompletely understood. Dendrites are often highly branched and coated with actin-filled, thorny protrusions, called dendritic spines, that allow for increased numbers of synaptic contacts with neighboring neurons. Read More

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http://dx.doi.org/10.1177/1179069518816088DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6287294PMC
December 2018
9 Reads

Environmental, economic and socio-cultural risk factors of recurrent seasonal epidemics of cerebrospinal meningitis in Kebbi state, northwestern Nigeria: a qualitative approach.

BMC Public Health 2018 Dec 13;18(Suppl 4):1318. Epub 2018 Dec 13.

World Health Organisation, Country Representative Office, Abuja, Nigeria.

Background: Kebbi State remains the epicentre of the seasonal epidemic meningitis in northwestern Nigeria despite interventions. In this setting, no previous study has been conducted to understand the risk factors of the recurrent meningitis epidemics using qualitative approach. Consequently, this study intends to explore and better understand the environmental, economic and socio-cultural factors of recurrent seasonal epidemic meninigitis using a qualitative approach. Read More

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https://bmcpublichealth.biomedcentral.com/articles/10.1186/s
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http://dx.doi.org/10.1186/s12889-018-6196-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6292165PMC
December 2018
7 Reads

Behind the wheel safety in palliative care: a literature review.

BMJ Support Palliat Care 2018 Dec 6. Epub 2018 Dec 6.

Cicely Saunders Institute of Palliative Care, Policy and Rehabilitation, Brixton, London, UK.

Background: Driving is a complex activity that requires physical abilities and adequate executive and cognitive functioning. There is concern among specialist palliative care services about patients continuing to drive despite having progressive incurable illnesses, comorbidities and medications to manage their symptoms.

Objectives: To determine the quality of literature available about driving that would apply to palliative care patients, specifically in relation to road test or simulated driving scores and neurocognitive testing. Read More

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http://spcare.bmj.com/lookup/doi/10.1136/bmjspcare-2018-0016
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http://dx.doi.org/10.1136/bmjspcare-2018-001639DOI Listing
December 2018
6 Reads

Eomes-expressing T-helper cells as potential target of therapy in chronic neuroinflammation.

Authors:
Shinji Oki

Neurochem Int 2018 Dec 1. Epub 2018 Dec 1.

Department of Immunology, National Institute of Neuroscience, National Center of Neurology and Psychiatry (NCNP), 4-1-1 Ogawahigashi, Kodaira, Tokyo, 187-8502, Japan. Electronic address:

Reserch progresses in understanding the pathogenicity of multiple sclerosis (MS) in the last couple of decade has enabled us to develop new drug entities available in the clinic. However, we still have not succeeded in preventing conversion from relapsing-remitting MS (RR-MS) to secondary progressive MS (SP-MS) and curing this intractable form of MS. Furthermore, diagnosis is usually retrospective and subjective, relying on gradual worsening of neurological signs/symptoms. Read More

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http://dx.doi.org/10.1016/j.neuint.2018.11.023DOI Listing
December 2018
1 Read

A Case Report of Impaired Driving Performance after a Concussion.

R I Med J (2013) 2018 Dec 3;101(10):56-57. Epub 2018 Dec 3.

Brown University, Department of Emergency Medicine.

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December 2018
1 Read

The Gold Nanocluster Protects Neurons Directly or via Inhibiting Cytotoxic Secretions of Microglia Cell.

J Nanosci Nanotechnol 2019 Apr;19(4):1986-1995

CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China.

Neurodegenerative diseases have become a huge challenge to public health, such as Alzheimer's and Parkinson's diseases. Microglia driving inflammation in the central nervous system (CNS) has been involved in the pathological process of these disorders and could be novel therapy target. However, traditional anti-inflammatory drugs are not effective in alleviating neuroinflammation. Read More

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http://dx.doi.org/10.1166/jnn.2019.15762DOI Listing
April 2019
1 Read

Elevated cerebrospinal fluid Galectin-9 is associated with central nervous system immune activation and poor cognitive performance in older HIV-infected individuals.

J Neurovirol 2018 Nov 26. Epub 2018 Nov 26.

Department of Tropical Medicine, Medical Microbiology & Pharmacology, John A. Burns School of Medicine, University of Hawai'i, 651 Ilalo St BSB 325, Honolulu, HI, 96813, USA.

We previously reported that galectin-9 (Gal-9), a soluble lectin with immunomodulatory properties, is elevated in plasma during HIV infection and induces HIV transcription. The link between Gal-9 and compromised neuronal function is becoming increasingly evident; however, the association with neuroHIV remains unknown. We measured Gal-9 levels by ELISA in cerebrospinal fluid (CSF) and plasma of 70 HIV-infected (HIV+) adults stratified by age (older > 40 years and younger < 40 years) either ART suppressed or with detectable CSF HIV RNA, including a subgroup with cognitive assessments, and 18 HIV uninfected (HIV-) controls. Read More

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http://link.springer.com/10.1007/s13365-018-0696-3
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http://dx.doi.org/10.1007/s13365-018-0696-3DOI Listing
November 2018
7 Reads

STING-mediated type-I interferons contribute to the neuroinflammatory process and detrimental effects following traumatic brain injury.

J Neuroinflammation 2018 Nov 21;15(1):323. Epub 2018 Nov 21.

Neuropharmacology Laboratory, Department of Pharmacology & Therapeutics, University of Melbourne, Parkville, Melbourne, 3010, Australia.

Background: Traumatic brain injury (TBI) represents a major cause of disability and death worldwide with sustained neuroinflammation and autophagy dysfunction contributing to the cellular damage. Stimulator of interferon genes (STING)-induced type-I interferon (IFN) signalling is known to be essential in mounting the innate immune response against infections and cell injury in the periphery, but its role in the CNS remains unclear. We previously identified the type-I IFN pathway as a key mediator of neuroinflammation and neuronal cell death in TBI. Read More

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http://dx.doi.org/10.1186/s12974-018-1354-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6247615PMC
November 2018
7 Reads

Diet-Induced Hyperinsulinemia as a Key Factor in the Etiology of Both Benign Prostatic Hyperplasia and Essential Hypertension?

Authors:
Wolfgang Kopp

Nutr Metab Insights 2018 8;11:1178638818773072. Epub 2018 May 8.

Former head of the Diagnostikzentrum Graz, Graz, Austria.

Benign prostatic hyperplasia and hypertension are common age-related comorbidities. Although the etiology of benign prostatic hyperplasia (BPH) is still largely unresolved and poorly understood, a significant age-independent association was found between BPH and hypertension, indicating a common pathophysiological factor for both diseases. It has previously been suggested that the development of essential hypertension may be related to diet-induced hyperinsulinemia. Read More

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http://dx.doi.org/10.1177/1178638818773072DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6238249PMC

TBX2 is a neuroblastoma core regulatory circuitry component enhancing MYCN/FOXM1 reactivation of DREAM targets.

Nat Commun 2018 11 19;9(1):4866. Epub 2018 Nov 19.

Center for Medical Genetics, Ghent University, Ghent, 9000, Belgium.

Chromosome 17q gains are almost invariably present in high-risk neuroblastoma cases. Here, we perform an integrative epigenomics search for dosage-sensitive transcription factors on 17q marked by H3K27ac defined super-enhancers and identify TBX2 as top candidate gene. We show that TBX2 is a constituent of the recently established core regulatory circuitry in neuroblastoma with features of a cell identity transcription factor, driving proliferation through activation of p21-DREAM repressed FOXM1 target genes. Read More

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http://www.nature.com/articles/s41467-018-06699-9
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http://dx.doi.org/10.1038/s41467-018-06699-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6242972PMC
November 2018
26 Reads

Different Fgfs have distinct roles in regulating neurogenesis after spinal cord injury in zebrafish.

Neural Dev 2018 11 17;13(1):24. Epub 2018 Nov 17.

Australian Regenerative Medicine Institute, Monash University, Clayton, VIC, 3800, Australia.

Background: Despite conserved developmental processes and organization of the vertebrate central nervous system, only some vertebrates including zebrafish can efficiently regenerate neural damage including after spinal cord injury. The mammalian spinal cord shows very limited regeneration and neurogenesis, resulting in permanent life-long functional impairment. Therefore, there is an urgent need to identify the cellular and molecular mechanisms that can drive efficient vertebrate neurogenesis following injury. Read More

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http://dx.doi.org/10.1186/s13064-018-0122-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6240426PMC
November 2018
2 Reads

Seizures occurring while driving in patients with and without diagnosis of epilepsy: Frequency and association with automobile accidents.

J Clin Neurosci 2019 Jan 13;59:75-78. Epub 2018 Nov 13.

Department of Neurology, Saiseikai Utsunomiya Hospital, Utsunomiya, Japan.

Seizure may occur during any human activity, including driving. The objectives of this study were to report the frequency of seizure occurring while driving, clarify patient characteristics and analyze the behavioral patterns of drivers afflicted by seizure. A single-center, retrospective study was conducted using prospectively acquired data. Read More

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http://dx.doi.org/10.1016/j.jocn.2018.11.003DOI Listing
January 2019

The History and Horizons of Microscale Neural Interfaces.

Micromachines (Basel) 2018 Sep 6;9(9). Epub 2018 Sep 6.

Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA 15261, USA.

Microscale neural technologies interface with the nervous system to record and stimulate brain tissue with high spatial and temporal resolution. These devices are being developed to understand the mechanisms that govern brain function, plasticity and cognitive learning, treat neurological diseases, or monitor and restore functions over the lifetime of the patient. Despite decades of use in basic research over days to months, and the growing prevalence of neuromodulation therapies, in many cases the lack of knowledge regarding the fundamental mechanisms driving activation has dramatically limited our ability to interpret data or fine-tune design parameters to improve long-term performance. Read More

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http://www.mdpi.com/2072-666X/9/9/445
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http://dx.doi.org/10.3390/mi9090445DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6187275PMC
September 2018
12 Reads

Visual field defects after radiosurgery versus temporal lobectomy for mesial temporal lobe epilepsy: Findings of the ROSE trial.

Seizure 2018 Dec 31;63:62-67. Epub 2018 Oct 31.

University of California San Diego, San Diego, CA, United States.

Purpose: Stereotactic radiosurgery (SRS) may be an alternative to anterior temporal lobectomy (ATL) for mesial temporal lobe epilepsy (MTLE). Visual field defects (VFD) occur in 9-100% of patients following open surgery for MTLE. Postoperative VFD after minimally invasive versus open surgery may differ. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10591311183035
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http://dx.doi.org/10.1016/j.seizure.2018.10.017DOI Listing
December 2018
10 Reads

Comprehensive analysis of Reverse Phase Protein Array data reveals characteristic unique proteomic signatures for glioblastoma subtypes.

Gene 2019 Feb 25;685:85-95. Epub 2018 Oct 25.

Department of Bio-Medical Sciences, School of Biosciences and Technology, VIT University, Vellore 632014, India. Electronic address:

The most common and lethal type of intracranial tumors include the astrocytomas. Grade IV astrocytoma or Glioblastoma (GBM) is highly aggressive and treatment-refractory with a median survival of only 14 to 16 months. Molecular profiling of GBMs reveals a high degree of intra- and inter-tumoral heterogeneity, and hence it is important to understand the important signalling axes that get deregulated in different GBM subtypes to provide effective tailor-made therapies. Read More

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http://dx.doi.org/10.1016/j.gene.2018.10.069DOI Listing
February 2019
3 Reads

Depression and Alzheimer's Disease Biomarkers Predict Driving Decline.

J Alzheimers Dis 2018 ;66(3):1213-1221

Charles F. and Joanne Knight Alzheimer's Disease Research Center, Washington University, School of Medicine, St. Louis, MO, USA.

Background: Symptomatic Alzheimer's disease (AD) and depression independently increase crash risk. Additionally, depression is both a risk factor for and a consequence of AD.

Objective: To examine whether a depression diagnosis, antidepressant use, and preclinical AD are associated with driving decline among cognitively normal older adults. Read More

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http://dx.doi.org/10.3233/JAD-180564DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330210PMC
January 2018
8 Reads

Development of a community-based golf and exercise program for people with Parkinson's disease.

Complement Ther Clin Pract 2018 Nov 24;33:149-155. Epub 2018 Sep 24.

2001 Newburg Road, Nolen C. Allen Hall, Physical Therapy Program, School of Movement and Rehabilitation Sciences, College of Health Professions, Bellarmine University, Louisville, KY, 40205, USA. Electronic address:

Individuals with Parkinson's disease (PD) typically display symptoms of rigidity, bradykinesia, and postural instability that can limit participation in recreational activities. The purpose of this clinical report is to describe the development, implementation, and outcomes of a novel and innovative community-based golf and exercise program for individuals with PD. In response to community interest, the program was developed through a unique partnership that blended the expertise of physical therapists and golf professionals. Read More

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http://dx.doi.org/10.1016/j.ctcp.2018.09.006DOI Listing
November 2018
24 Reads

δ-Secretase-cleaved Tau stimulates Aβ production via upregulating STAT1-BACE1 signaling in Alzheimer's disease.

Mol Psychiatry 2018 Oct 31. Epub 2018 Oct 31.

Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, 30322, USA.

δ-Secretase, an age-dependent asparagine protease, cleaves both amyloid precursor protein (APP) and Tau and is required for amyloid plaque and neurofibrillary tangle pathologies in Alzheimer's disease (AD). However, whether δ-secretase activation is sufficient to trigger AD pathogenesis remains unknown. Here we show that the fragments of δ-secretase-cleavage, APP (586-695) and Tau(1-368), additively drive AD pathogenesis and cognitive dysfunctions. Read More

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http://dx.doi.org/10.1038/s41380-018-0286-zDOI Listing
October 2018
5 Reads

Calcium Signaling in Vertebrate Development and Its Role in Disease.

Int J Mol Sci 2018 Oct 30;19(11). Epub 2018 Oct 30.

College of William and Mary, Williamsburg, VA 23187, USA.

Accumulating evidence over the past three decades suggests that altered calcium signaling during development may be a major driving force for adult pathophysiological events. Well over a hundred human genes encode proteins that are specifically dedicated to calcium homeostasis and calcium signaling, and the majority of these are expressed during embryonic development. Recent advances in molecular techniques have identified impaired calcium signaling during development due to either mutations or dysregulation of these proteins. Read More

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http://www.mdpi.com/1422-0067/19/11/3390
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http://dx.doi.org/10.3390/ijms19113390DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274931PMC
October 2018
1 Read

Sex differences in autoimmune disorders of the central nervous system.

Semin Immunopathol 2019 Mar 25;41(2):177-188. Epub 2018 Oct 25.

Institute of Neuroimmunology and Multiple Sclerosis (INIMS), Center for Molecular Neurobiology Hamburg (ZMNH), University Medical Center Hamburg Eppendorf, Hamburg, Germany.

Stronger adaptive immune responses in females can be observed in different mammals, resulting in better control of infections compared to males. However, this presumably evolutionary difference likely also drives higher incidence of autoimmune diseases observed in humans. Here, we summarize sex differences in the most common autoimmune diseases of the central nervous system (CNS) and discuss recent advances in the understanding of possible underlying immunological and CNS intrinsic mechanisms. Read More

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http://dx.doi.org/10.1007/s00281-018-0723-8DOI Listing
March 2019
2 Reads

The glymphatic pathway in neurological disorders.

Lancet Neurol 2018 Nov;17(11):1016-1024

Centre for Translational Neuromedicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Center for Translational Neuromedicine, Department of Neurosurgery, University of Rochester Medical Center, Rochester, NY, USA; Department of Neuroscience, University of Rochester Medical Center, Rochester, NY, USA. Electronic address:

Background: The glymphatic (glial-lymphatic) pathway is a fluid-clearance pathway identified in the rodent brain in 2012. This pathway subserves the flow of CSF into the brain along arterial perivascular spaces and subsequently into the brain interstitium, facilitated by aquaporin 4 (AQP4) water channels. The pathway then directs flow towards the venous perivascular and perineuronal spaces, ultimately clearing solutes from the neuropil into meningeal and cervical lymphatic drainage vessels. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S14744422183031
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http://dx.doi.org/10.1016/S1474-4422(18)30318-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6261373PMC
November 2018
18 Reads

Low-Frequency and Rare-Coding Variation Contributes to Multiple Sclerosis Risk.

Authors:

Cell 2018 Nov 18;175(6):1679-1687.e7. Epub 2018 Oct 18.

Multiple sclerosis is a complex neurological disease, with ∼20% of risk heritability attributable to common genetic variants, including >230 identified by genome-wide association studies. Multiple strands of evidence suggest that much of the remaining heritability is also due to additive effects of common variants rather than epistasis between these variants or mutations exclusive to individual families. Here, we show in 68,379 cases and controls that up to 5% of this heritability is explained by low-frequency variation in gene coding sequence. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00928674183126
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http://dx.doi.org/10.1016/j.cell.2018.09.049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269166PMC
November 2018
4 Reads

HIV Tat causes synapse loss in a mouse model of HIV-associated neurocognitive disorder that is independent of the classical complement cascade component C1q.

Glia 2018 12 16;66(12):2563-2574. Epub 2018 Oct 16.

Center for Neurotherapeutics Discovery, University of Rochester Medical Center, Rochester, New York.

Microglial activation, increased proinflammatory cytokine production, and a reduction in synaptic density are key pathological features associated with HIV-associated neurocognitive disorders (HAND). Even with combination antiretroviral therapy (cART), more than 50% of HIV-positive individuals experience some type of cognitive impairment. Although viral replication is inhibited by cART, HIV proteins such as Tat are still produced within the nervous system that are neurotoxic, involved in synapse elimination, and provoke enduring neuroinflammation. Read More

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http://dx.doi.org/10.1002/glia.23511DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6309507PMC
December 2018
1 Read

Ethical Issues in Vascular Neurology.

Semin Neurol 2018 10 15;38(5):515-521. Epub 2018 Oct 15.

Department of Neurology, University of Wisconsin, Madison, Wisconsin.

There are ethical aspects to each of the three phases of cerebrovascular disease: hyperacute management, acute prognostication and management of early complications, and long-term recovery and reintegration with the community. This article addresses ethical concerns pertinent to each phase. First, we discuss ethical issues regarding consent for thrombolysis and endovascular treatment for acute ischemic stroke, including a review of considerations regarding the provision of acute stroke treatment advice over the telephone. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/s-0038-1667383
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http://dx.doi.org/10.1055/s-0038-1667383DOI Listing
October 2018
20 Reads

Therapeutic opportunities and pitfalls in the treatment of axon degeneration.

Curr Opin Neurol 2018 Dec;31(6):693-701

Departments of Neurosurgery and Neuroscience, Baylor College of Medicine, Houston, Texas.

Purpose Of Review: The current review analyzes recent findings that suggest that axon degeneration is a druggable process in the treatment of neurodegenerative disorders and a subset of traumas.

Recent Findings: Emerging evidence reveals that axon degeneration is an active and regulated process in the early progression of some neurodegenerative diseases and acute traumas, which is orchestrated through a combination of axon-intrinsic and somatically derived signaling events. The identification of these pathways has presented appealing drug targets whose specificity for the nervous system and phenotypes in mouse models offers significant clinical opportunity. Read More

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http://Insights.ovid.com/crossref?an=00019052-900000000-9908
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http://dx.doi.org/10.1097/WCO.0000000000000621DOI Listing
December 2018
8 Reads

High burden of neurological disease in the older general population: results from the Canadian Longitudinal Study on Aging.

Eur J Neurol 2019 Feb 31;26(2):356-362. Epub 2018 Oct 31.

Centre de Recherche du Centre hospitalier de l'Université de Montréal, Montreal, QC.

Background And Purpose: Our objective was to study the association between the presence of a neurological disease and the comorbidity burden as well as healthcare utilization (HCU).

Methods: Using baseline data from the Canadian Longitudinal Study on Aging (CLSA), we examined the burden of five neurological conditions. The CLSA is a population-based study of approximately 50 000 individuals, aged 45-85 years at baseline. Read More

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http://dx.doi.org/10.1111/ene.13823DOI Listing
February 2019
3 Reads

Transcriptional profiling of embryos lacking the lipoprotein receptor SR-B1 reveals a regulatory circuit governing a neurodevelopmental or metabolic decision during neural tube closure.

BMC Genomics 2018 Oct 5;19(1):731. Epub 2018 Oct 5.

Department of Nutrition, Diabetes, and Metabolism, School of Medicine, Pontificia Universidad Católica de Chile, Marcoleta 367, 83300024, Santiago, CP, Chile.

Background: The high-density lipoprotein receptor SR-B1 mediates cellular uptake of several lipid species, including cholesterol and vitamin E. During early mouse development, SR-B1 is located in the maternal-fetal interface, where it facilitates vitamin E transport towards the embryo. Consequently, mouse embryos lacking SR-B1 are vitamin E-deficient, and around half of them fail to close the neural tube and show cephalic neural tube defects (NTD). Read More

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http://dx.doi.org/10.1186/s12864-018-5110-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6173885PMC
October 2018
9 Reads

Addictive Eating and Its Relation to Physical Activity and Sleep Behavior.

Nutrients 2018 Oct 4;10(10). Epub 2018 Oct 4.

School of Health Sciences, Faculty of Health and Medicine, The University of Newcastle, Callaghan, NSW 2308, Australia.

The obesity epidemic has led to the exploration of factors contributing to its etiology. Addictive eating, physical activity, and sleep behaviors have all been independently associated with obesity, and recent research suggests plausible interrelationships between food addiction, physical activity, and sleep. This study aims to investigate the relationship between food addiction with physical activity and sleep behavior. Read More

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http://dx.doi.org/10.3390/nu10101428DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6212870PMC
October 2018
1 Read

Determining the likelihood that fatigue was present in a road accident: A theoretical review and suggested accident taxonomy.

Sleep Med Rev 2018 12 29;42:202-210. Epub 2018 Aug 29.

Appleton Institute, Central Queensland University, Adelaide Campus, 44 Greenhill Rd., South Australia 5034, Australia.

Estimates in developed countries of the extent to which fatigue contributes to road accidents range from as low as 5% to as high as 50% of all accidents. Compared with other causes of road accidents (e.g. Read More

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http://dx.doi.org/10.1016/j.smrv.2018.08.006DOI Listing
December 2018
2 Reads

Ageing, Cellular Senescence and Neurodegenerative Disease.

Int J Mol Sci 2018 Sep 27;19(10). Epub 2018 Sep 27.

Laboratory of Histology & Embryology, Medical School, National and Kapodistrian University of Athens, 75 Mikras Asias Street, Goudi, 115-27 Athens, Greece.

Ageing is a major risk factor for developing many neurodegenerative diseases. Cellular senescence is a homeostatic biological process that has a key role in driving ageing. There is evidence that senescent cells accumulate in the nervous system with ageing and neurodegenerative disease and may predispose a person to the appearance of a neurodegenerative condition or may aggravate its course. Read More

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http://dx.doi.org/10.3390/ijms19102937DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6213570PMC
September 2018
4 Reads
2.862 Impact Factor

Galectin-3-Mediated Glial Crosstalk Drives Oligodendrocyte Differentiation and (Re)myelination.

Front Cell Neurosci 2018 12;12:297. Epub 2018 Sep 12.

Department of Biological Chemistry, School of Pharmacy and Biochemistry, University of Buenos Aires, Buenos Aires, Argentina.

Galectin-3 (Gal-3) is the only chimeric protein in the galectin family. Gal-3 structure comprises unusual tandem repeats of proline and glycine-rich short stretches bound to a carbohydrate-recognition domain (CRD). The present review summarizes Gal-3 functions in the extracellular and intracellular space, its regulation and its internalization and secretion, with a focus on the current knowledge of Gal-3 role in central nervous system (CNS) health and disease, particularly oligodendrocyte (OLG) differentiation, myelination and remyelination in experimental models of multiple sclerosis (MS). Read More

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https://www.frontiersin.org/article/10.3389/fncel.2018.00297
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http://dx.doi.org/10.3389/fncel.2018.00297DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6143789PMC
September 2018
10 Reads

Therapeutic Advances and Challenges in the Treatment of Progressive Multiple Sclerosis.

Drugs 2018 Oct;78(15):1549-1566

Mellen Center for Multiple Sclerosis Treatment and Research, Neurological Institute, Cleveland Clinic, 9500 Euclid Ave, U-10, Cleveland, OH, 44195, USA.

Despite the fact that majority of patients with multiple sclerosis (MS) have relapsing-remitting disease, many transition to secondary progressive disease (SPMS) over time. This transition is thought to be related to neurodegenerative processes increasingly predominating over inflammatory processes as the driving forces of disability. However, some patients initially present with primary progressive disease (PPMS) that is characterized by a gradual accumulation of neurological symptoms and subsequent disability accumulation. Read More

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http://dx.doi.org/10.1007/s40265-018-0984-5DOI Listing
October 2018
1 Read

Agreement of driving simulator and on-road driving performance in patients with binocular visual field loss.

Graefes Arch Clin Exp Ophthalmol 2018 Dec 24;256(12):2429-2435. Epub 2018 Sep 24.

Department of Ophthalmology, University Hospital of Larissa, Mezourlo Area, 41222, Larissa, Greece.

Purpose: On-road testing is considered the standard for assessment of driving performance; however, it lacks standardization. In contrast, driving simulators provide controlled experimental settings in a virtual reality environment. This study compares both testing conditions in patients with binocular visual field defects due to bilateral glaucomatous optic neuropathy or due to retro-chiasmal visual pathway lesions. Read More

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http://dx.doi.org/10.1007/s00417-018-4148-9DOI Listing
December 2018
3 Reads

Driving Ability in Alzheimer Disease Spectrum: Neural Basis, Assessment, and Potential Use of Optic Flow Event-Related Potentials.

Front Neurol 2018 7;9:750. Epub 2018 Sep 7.

Department of Clinical Neurophysiology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

Driving requires multiple cognitive functions including visuospatial perception and recruits widespread brain networks. Recently, traffic accidents in dementia, particularly in Alzheimer disease spectrum (ADS), have increased and become an urgent social problem. Therefore, it is necessary to develop the objective and reliable biomarkers for driving ability in patients with ADS. Read More

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http://dx.doi.org/10.3389/fneur.2018.00750DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6137098PMC
September 2018
2 Reads

Single-cell RNA-seq reveals dynamic transcriptome profiling in human early neural differentiation.

Gigascience 2018 11 1;7(11). Epub 2018 Nov 1.

BGI-Shenzhen, Shenzhen 518083, China.

Background: Investigating cell fate decision and subpopulation specification in the context of the neural lineage is fundamental to understanding neurogenesis and neurodegenerative diseases. The differentiation process of neural-tube-like rosettes in vitro is representative of neural tube structures, which are composed of radially organized, columnar epithelial cells and give rise to functional neural cells. However, the underlying regulatory network of cell fate commitment during early neural differentiation remains elusive. Read More

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https://academic.oup.com/gigascience/advance-article/doi/10.
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http://dx.doi.org/10.1093/gigascience/giy117DOI Listing
November 2018
37 Reads

Effect of γ-hydroxybutyrate (GHB) on driving as measured by a driving simulator.

Psychopharmacology (Berl) 2018 Nov 19;235(11):3223-3232. Epub 2018 Sep 19.

Departments of Medicine and Bioengineering & Therapeutic Sciences, The University of California San Francisco, San Francisco, CA, USA.

Rationale: Gamma-hydroxybutyrate acid (GHB), a GABA receptor agonist approved for treatment of narcolepsy, impairs driving ability, but little is known about doses and plasma concentrations associated with impairment and time course of recovery.

Objective: To assess effects of oral GHB (Xyrem®) upon driving as measured by a driving simulator, and to determine plasma concentrations associated with impairment and the time course of recovery.

Methods: Randomized, double-blind, two-arm crossover study, during which 16 participants received GHB 50 mg/kg orally or placebo. Read More

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http://dx.doi.org/10.1007/s00213-018-5025-2DOI Listing
November 2018
4 Reads

Daytime Sleepiness Among Young Adult Omani Car Drivers.

Sultan Qaboos Univ Med J 2018 May 9;18(2):e143-e148. Epub 2018 Sep 9.

Department of Family Medicine & Public Health, College of Medicine & Health Sciences, Sultan Qaboos University, Muscat, Oman.

Objectives: Sleepiness and fatigue play significant roles in exacerbating the occurrence of car crashes. However, there is a dearth of studies examining the prevalence of sleepiness while driving among Omanis. This study aimed to determine the proportion of young Omani adults who confess to daytime sleepiness while driving and to investigate associations between gender, daytime sleepiness and risk of obstructive sleep apnoea syndrome (OSAS). Read More

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http://dx.doi.org/10.18295/squmj.2018.18.02.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6132520PMC
May 2018
2 Reads

Modeling Complex Neurological Diseases with Stem Cells: A Study of Bipolar Disorder.

Results Probl Cell Differ 2018 ;66:265-282

Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA.

The pathogenesis of bipolar disorder (BPD) is unknown. Using human-induced pluripotent stem cells (hiPSCs) to unravel pathological mechanisms in polygenic diseases is challenging, with few successful studies to date. However, hiPSCs from BPD patients responsive to lithium have offered unique opportunities to discern lithium's mechanism of action and hence gain insight into BPD pathology. Read More

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http://dx.doi.org/10.1007/978-3-319-93485-3_12DOI Listing
January 2018
4 Reads

Inversion produces opposite size illusions for faces and bodies.

Acta Psychol (Amst) 2018 Nov 5;191:15-24. Epub 2018 Sep 5.

Department of Psychological Sciences, Birkbeck, University of London, UK.

Faces are complex, multidimensional, and meaningful visual stimuli. Recently, Araragi, Aotani, & Kitaoka (2012) demonstrated an intriguing face size illusion whereby an inverted face is perceived as larger than a physically identical upright face. Like the face, the human body is a highly familiar and important stimulus in our lives. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00016918183012
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http://dx.doi.org/10.1016/j.actpsy.2018.08.017DOI Listing
November 2018
16 Reads

Red Flags and Off Ramps: Providing Community Education About Driving and Dementia.

Home Healthc Now 2018 Sep/Oct;36(5):319-323

Diane K. Pastor, PhD, MBA, NP-C, is an Associate Professor of Nursing, School of Nursing, University of North Carolina Wilmington, Wilmington, North Carolina. Tamatha Arms, DNP, PMHNP-BC, NP-C, is an Assistant Professor of Nursing, School of Nursing, University of North Carolina Wilmington, Wilmington, North Carolina. Andrea L. Jones, PhD, MSW, is an Assistant Professor of Social Work, College of Health and Human Services, University of North Carolina Wilmington, Wilmington, North Carolina.

Driving safety for older adults with dementia presents a continuing complex challenge in the community. More than 5 million people in the United States suffer from dementia, and their numbers are expected to grow. Evidence-based resources to identify and manage driving risks in older adults with dementia do exist, but the challenges of limited time in primary care and outpatient settings can make application difficult. Read More

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http://dx.doi.org/10.1097/NHH.0000000000000695DOI Listing
January 2019
8 Reads