6,567 results match your criteria Driving and Neurological Disease


CARD9 microglia promote antifungal immunity via IL-1β- and CXCL1-mediated neutrophil recruitment.

Nat Immunol 2019 05 17;20(5):559-570. Epub 2019 Apr 17.

Fungal Pathogenesis Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy & Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.

The C-type lectin receptor-Syk (spleen tyrosine kinase) adaptor CARD9 facilitates protective antifungal immunity within the central nervous system (CNS), as human deficiency in CARD9 causes susceptibility to fungus-specific, CNS-targeted infection. CARD9 promotes the recruitment of neutrophils to the fungus-infected CNS, which mediates fungal clearance. In the present study we investigated host and pathogen factors that promote protective neutrophil recruitment during invasion of the CNS by Candida albicans. Read More

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http://www.nature.com/articles/s41590-019-0377-2
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http://dx.doi.org/10.1038/s41590-019-0377-2DOI Listing
May 2019
4 Reads

CGRP and the Trigeminal System in Migraine.

Headache 2019 Apr 14. Epub 2019 Apr 14.

Eli Lilly and Company, Indianapolis, IN, USA.

Objective: The goal of this narrative review is to provide an overview of migraine pathophysiology, with an emphasis on the role of calcitonin gene-related peptide (CGRP) within the context of the trigeminovascular system.

Background: Migraine is a prevalent and disabling neurological disease that is characterized in part by intense, throbbing, and unilateral headaches. Despite recent advances in understanding its pathophysiology, migraine still represents an unmet medical need, as it is often underrecognized and undertreated. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/head.13529
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http://dx.doi.org/10.1111/head.13529DOI Listing
April 2019
2 Reads

Alterations in Striatal microRNA-mRNA Networks Contribute to Neuroinflammation in Multiple System Atrophy.

Mol Neurobiol 2019 Apr 9. Epub 2019 Apr 9.

Department of Neuroscience, University of California San Diego, 9500 Gilman Dr., MTF 344 MC0624, La Jolla, CA, 92093-0624, USA.

Multiple systems atrophy (MSA) is a rare neurodegenerative disorder characterized by the accumulation of α-synuclein in glial cells and neurodegeneration in the striatum, substantia nigra, and cerebellum. Aberrant miRNA regulation has been associated with neurodegeneration, including alterations of specific miRNAs in brain tissue, serum, and cerebrospinal fluid from MSA patients. Still, a causal link between deregulation of miRNA networks and pathological changes in the transcriptome remains elusive. Read More

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http://link.springer.com/10.1007/s12035-019-1577-3
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http://dx.doi.org/10.1007/s12035-019-1577-3DOI Listing
April 2019
1 Read

A 2.5-Year Longitudinal Assessment of Naturalistic Driving in Preclinical Alzheimer's Disease.

J Alzheimers Dis 2019 Apr 3. Epub 2019 Apr 3.

Charles F. and Joanne Knight Alzheimer's Disease Research Center, Washington University School of Medicine, MO, USA.

Background: Emerging evidence shows that cognitively normal older adults with preclinical Alzheimer's disease (AD) make more errors and are more likely to receive a marginal/fail rating on a standardized road test compared to older adults without preclinical AD, but the extent to which preclinical AD impacts everyday driving behavior is unknown.

Objective: To examine self-reported and naturalistic longitudinal driving behavior among persons with and without preclinical AD.

Method: We prospectively followed cognitively normal drivers (aged 65 + years) with (n = 10) and without preclinical AD (n = 10) for 2. Read More

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http://dx.doi.org/10.3233/JAD-181242DOI Listing
April 2019
1 Read

Circadian Rhythms: Will It Revolutionise the Management of Diseases?

J Lifestyle Med 2019 Jan 31;9(1):1-11. Epub 2019 Jan 31.

University College London Medical School, London, United Kingdom.

The Nobel Prize for Medicine in 2017 was awarded to Michael Young, Michael Rosbash and Jeffrey Hall for their discoveries into the molecular mechanisms controlling circadian rhythms (CR). The aims of this paper were to present the mechanisms behind the CRs and discuss the impact this could have on human health. We argued that further research in this field has the potential to revolutionise healthcare through understanding the influence on the pathogenesis of disease, including in cardiovascular, mental and neurological health, as well as influence on cognitive function. Read More

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http://dx.doi.org/10.15280/jlm.2019.9.1.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425903PMC
January 2019
1 Read

Syndecan 1 is a critical mediator of macropinocytosis in pancreatic cancer.

Nature 2019 Apr 27;568(7752):410-414. Epub 2019 Mar 27.

Department of Genomic Medicine, University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Pancreatic ductal adenocarcinoma (PDAC) remains recalcitrant to all forms of cancer treatment and carries a five-year survival rate of only 8%. Inhibition of oncogenic KRAS (hereafter KRAS*), the earliest lesion in disease development that is present in more than 90% of PDACs, and its signalling surrogates has yielded encouraging preclinical results with experimental agents. However, KRAS*-independent disease recurrence following genetic extinction of Kras* in mouse models anticipates the need for co-extinction strategies. Read More

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http://dx.doi.org/10.1038/s41586-019-1062-1DOI Listing
April 2019
2 Reads
42.351 Impact Factor

Transcriptome Analysis of the Human Tibial Nerve Identifies Sexually Dimorphic Expression of Genes Involved in Pain, Inflammation, and Neuro-Immunity.

Front Mol Neurosci 2019 5;12:37. Epub 2019 Mar 5.

School of Behavioral and Brain Sciences, The University of Texas at Dallas, Richardson, TX, United States.

Sex differences in gene expression are important contributors to normal physiology and mechanisms of disease. This is increasingly apparent in understanding and potentially treating chronic pain where molecular mechanisms driving sex differences in neuronal plasticity are giving new insight into why certain chronic pain disorders preferentially affect women vs. men. Read More

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http://dx.doi.org/10.3389/fnmol.2019.00037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6412153PMC
March 2019
1 Read

Insights into the Potential Role of Mercury in Alzheimer's Disease.

J Mol Neurosci 2019 Apr 15;67(4):511-533. Epub 2019 Mar 15.

Research Department, Innlandet Hospital Trust, Brumunddal, Norway.

Mercury (Hg), which is a non-essential element, is considered a highly toxic pollutant for biological systems even when present at trace levels. Elevated Hg exposure with the growing release of atmospheric pollutant Hg and rising accumulations of mono-methylmercury (highly neurotoxic) in seafood products have increased its toxic potential for humans. This review aims to highlight the potential relationship between Hg exposure and Alzheimer's disease (AD), based on the existing literature in the field. Read More

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http://dx.doi.org/10.1007/s12031-019-01274-3DOI Listing
April 2019
1 Read
2.343 Impact Factor

Converging and Differential Brain Phospholipid Dysregulation in the Pathogenesis of Repetitive Mild Traumatic Brain Injury and Alzheimer's Disease.

Front Neurosci 2019 19;13:103. Epub 2019 Feb 19.

Roskamp Institute, Sarasota, FL, United States.

Repetitive mild traumatic brain injury (rmTBI) is a major epigenetic risk factor for Alzheimer's disease (AD). The precise nature of how rmTBI leads to or precipitates AD pathology is currently unknown. Numerous neurological conditions have shown an important role for dysfunctional phospholipid metabolism as a driving factor for the pathogenesis of neurodegenerative diseases. Read More

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http://dx.doi.org/10.3389/fnins.2019.00103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390207PMC
February 2019

Factors associated with seizure-related motor vehicle accidents among patients with epilepsy in West China.

Seizure 2019 Mar 30;66:42-46. Epub 2019 Jan 30.

Department of Neurology, West China Hospital, Sichuan University, No. 37 Guoxue Road, Chengdu, Sichuan, 610041, People's Republic of China. Electronic address:

Purpose: This study was conducted to investigate the relevant demographics and clinical factors contributing to seizure-related motor vehicle accidents in west China.

Methods: All driving patients who visited our epilepsy clinic in the West China Hospital, between October 2012 and October 2016, were invited to participate. Data on social demographics, clinical features, and motor vehicle accidents were collected during structured interviews. Read More

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http://dx.doi.org/10.1016/j.seizure.2019.01.028DOI Listing
March 2019
1 Read

Cognitive Fitness to Drive in Huntington's Disease: Assessing the Clinical Utility of DriveSafe DriveAware.

J Huntingtons Dis 2019 ;8(1):87-95

Calvary Health Care Bethlehem, Statewide Progressive Neurological Disease Service, Caulfield South, VIC, Australia.

Background: DriveSafe DriveAware (DSDA) has been validated as an off-road screening tool for predicting on-road driving performance in clinical populations, but its utility in people with Huntington's disease (HD) is unknown.

Objective: Our aim was to evaluate the utility of DSDA in people with HD by demonstrating sensitivity of DSDA scores to HD progression and exploring associations between DSDA performance and cognitive functions that are essential to driving and impaired in people with HD.

Methods: We administered the iPad application version of DSDA to 26 pre-symptomatic and symptomatic participants with HD. Read More

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http://dx.doi.org/10.3233/JHD-180323DOI Listing
January 2019
10 Reads

Biomarkers in Adult Dermatomyositis: Tools to Help the Diagnosis and Predict the Clinical Outcome.

J Immunol Res 2019 14;2019:9141420. Epub 2019 Jan 14.

INSERM U976, Laboratory of Oncodermatology, Immunology, and Cutaneous Stem Cells, Hôpital Saint-Louis, Paris, France.

Dermatomyositis pathophysiology is complex. In recent years, medical research has identified molecules associated with disease activity. Besides providing insights into the driving mechanisms of dermatomyositis, these findings could provide potential biomarkers. Read More

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http://dx.doi.org/10.1155/2019/9141420DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350546PMC
April 2019
2 Reads

Effects of simulated mild vision loss on gaze, driving and interaction behaviors in pedestrian crossing situations.

Accid Anal Prev 2019 Apr 10;125:138-151. Epub 2019 Feb 10.

Schepens Eye Research Institute of Massachusetts Eye and Ear, Harvard Medical School, Boston, MA, United States.

Purpose: Interaction is the process of behavior adaption between two or more participants primarily based on what they visually perceive. It is an important aspect of traffic participation and supports a safe and efficient flow of traffic. However, prior driving simulator studies investigating the effects of vision impairment have typically used pre-programmed pedestrians that did not interact with the human driver. Read More

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http://dx.doi.org/10.1016/j.aap.2019.01.026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417430PMC

The effects of auditory satellite navigation instructions and visual blur on road hazard perception.

Accid Anal Prev 2019 Apr 8;125:132-137. Epub 2019 Feb 8.

School of Optometry and Vision Science and Institute of Health and Biomedical Innovation, Queensland University of Technology, Australia.

The distracting effects of mobile telephone use while driving are well known, however the effects of other sources of distraction, such as auditory navigation devices, are less well understood. Whether the effects of auditory distraction might interact with other sensory impairments, such as vision impairment, is of interest given that visual impairment is relatively common within the population, particularly as a result of uncorrected refractive error. In this experiment, 20 current drivers (mean age of 29. Read More

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http://dx.doi.org/10.1016/j.aap.2019.01.025DOI Listing

Tau and TDP-43 proteinopathies: kindred pathologic cascades and genetic pleiotropy.

Lab Invest 2019 Feb 11. Epub 2019 Feb 11.

University of Kentucky College of Medicine, Lexington, KY, USA.

We review the literature on Tau and TDP-43 proteinopathies in aged human brains and the relevant underlying pathogenetic cascades. Complex interacting pathways are implicated in Alzheimer's disease and related dementias (ADRD), wherein multiple proteins tend to misfold in a manner that is "reactive," but, subsequently, each proteinopathy may contribute strongly to the clinical symptoms. Tau proteinopathy exists in brains of individuals across a broad spectrum of primary underlying conditions-e. Read More

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http://dx.doi.org/10.1038/s41374-019-0196-yDOI Listing
February 2019
17 Reads

Development and Implementation of a Multi-Disciplinary Technology Enhanced Care Pathway for Youth and Adults with Concussion.

J Vis Exp 2019 Jan 20(143). Epub 2019 Jan 20.

Department of Biomedical Engineering, Cleveland Clinic Foundation; Concussion Center, Cleveland Clinic Foundation.

The evidence-informed standardization of care along disease lines is recommended to improve outcomes and reduce healthcare costs. The aim of this project is to 1) describe the development and implementation of the Concussion Carepath, 2) demonstrate the process of integrating technology in the form of a mobile application to enable the carepath and guide clinical decision-making, and 3) present data on the utility of the C3 app in facilitating decision-making throughout the injury recovery process. A multi-disciplinary team of experts in concussion care was formed to develop an evidence-informed algorithm, outlining best practices for the clinical management of concussion along three phases of recovery - acute, subacute, and post-concussive. Read More

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https://www.jove.com/video/58962/development-implementation-
Publisher Site
http://dx.doi.org/10.3791/58962DOI Listing
January 2019
8 Reads

Headache due to spinothalamic tract injury in patients with mild traumatic brain injury: Two case reports.

Medicine (Baltimore) 2019 Feb;98(6):e14306

Department of Physical Medicine and Rehabilitation, College of Medicine, Yeungnam University, Republic of Korea.

Rationale: Headache is the most common physical complaint reported by the following traumatic brain injury (TBI). Several studies using diffusion tensor tractography (DTT) have demonstrated that injury of the spinothalamic tract (STT) is a pathogenetic mechanism of central pain following TBI. However, no study of headache due to injury of the STT has been reported. Read More

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http://dx.doi.org/10.1097/MD.0000000000014306DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380840PMC
February 2019

Epilepsy in adults.

Lancet 2019 02 24;393(10172):689-701. Epub 2019 Jan 24.

Stichting Epilepsie Instellingen Nederland (SEIN), Heemstede, Netherlands; NIHR University College London Hospitals Biomedical Research Centre, UCL Queen Square Institute of Neurology, London, UK; Chalfont Centre for Epilepsy, Chalfont St Peter, UK. Electronic address:

Epilepsy is one of the most common serious brain conditions, affecting over 70 million people worldwide. Its incidence has a bimodal distribution with the highest risk in infants and older age groups. Progress in genomic technology is exposing the complex genetic architecture of the common types of epilepsy, and is driving a paradigm shift. Read More

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http://dx.doi.org/10.1016/S0140-6736(18)32596-0DOI Listing
February 2019
1 Read
45.217 Impact Factor

OLIMPIC: a 12-month study on the criteria driving retreatment with ranibizumab in patients with visual impairment due to myopic choroidal neovascularization.

Graefes Arch Clin Exp Ophthalmol 2019 Apr 24;257(4):759-768. Epub 2019 Jan 24.

Novartis Farma SpA, Largo Umberto Boccioni 1, 21040, Origgio, VA, Italy.

Purpose: To evaluate criteria driving retreatment with ranibizumab in Italian patients with myopic choroidal neovascularization (mCNV).

Methods: OLIMPIC was a 12-month, phase IIIb, open-label study. Patients with active mCNV were treated with ranibizumab 0. Read More

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http://dx.doi.org/10.1007/s00417-019-04248-8DOI Listing

Factors interfering with parenthood decision-making in an Italian sample of people with multiple sclerosis: an exploratory online survey.

J Neurol 2019 Mar 16;266(3):707-716. Epub 2019 Jan 16.

First Division of Neurology, University of Campania Luigi Vanvitelli, Piazza Miraglia, 2, 80138, Naples, Italy.

Background: Little is known about the influence of multiple sclerosis (MS) diagnosis on parenthood attitude in people with MS (pwMS).

Objective: To investigate the impact of diagnosis, clinical features and external disease-related influences on parenthood decision-making in Italian pwMS.

Methods: A web-based survey was posted on SMsocialnetwork. Read More

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http://dx.doi.org/10.1007/s00415-019-09193-4DOI Listing
March 2019
1 Read

Sympathetic nervous system in age-related cardiovascular dysfunction: Pathophysiology and therapeutic perspective.

Int J Biochem Cell Biol 2019 Mar 9;108:29-33. Epub 2019 Jan 9.

Center for Translational Medicine and Department of Pharmacology, Lewis Katz School of Medicine, Temple University, Philadelphia, USA. Electronic address:

Cardiovascular diseases such as heart failure and metabolic syndrome have high prevalence in the elderly population and are leading causes of death, disability, hospitalization, driving high healthcare costs worldwide. To reduce this social and economic burden there is urgency to find effective therapeutic targets. Several studies have linked the dysfunction of the Sympathetic Nervous System and β-adrenergic receptor signaling with the pathogenesis of age-related cardiovascular diseases. Read More

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http://dx.doi.org/10.1016/j.biocel.2019.01.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6383565PMC
March 2019
1 Read

When Is It Safe to Drive after Mild Traumatic Brain Injury/Sports-related Concussion?

Curr Sports Med Rep 2019 Jan;18(1):17-19

Department of Family and Community Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM.

Driving an automobile has inherent danger, and driving after mild traumatic brain injury (mTBI)/sports-related concussion (SRC) can make this task even more hazardous. There is evidence to suggest that restriction from driving for the first 24 to 48 h after mTBI/SRC is probably reasonable. However, after the first 48 h have passed, there is insufficient evidence to make a recommendation regarding return to driving. Read More

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http://dx.doi.org/10.1249/JSR.0000000000000558DOI Listing
January 2019
2 Reads

Regulation of P2X7 receptor expression and function in the brain.

Brain Res Bull 2018 Dec 26. Epub 2018 Dec 26.

Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin, Ireland; FutureNeuro Research Centre, Dublin, Ireland.

Because of its prominent role in driving inflammatory processes, the ATP-gated purinergic P2X7 receptor has attracted much attention over the past decade as a potential therapeutic target for numerous human conditions, particularly diseases of the central nervous system, including neurodegenerative diseases (e.g. Alzheimer's and Huntington's disease), psychiatric disorders (e. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03619230183073
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http://dx.doi.org/10.1016/j.brainresbull.2018.12.008DOI Listing
December 2018
12 Reads

Real Awareness in the NICU and Through the Lifespan.

Authors:
Deborah Discenza

Neonatal Netw 2018 Jul 1;37(4):248-249. Epub 2018 Jul 1.

Awareness of prematurity goes well beyond the birth and the NICU stay. It is a life span matter, one that the neonatal field needs to re-think in terms of helping better the outcomes in babies. Deb Discenza tells the all-too-real scenario of her daughter's fate and how that is driving her passion of advocating for preemies and their families to a whole new level. Read More

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http://dx.doi.org/10.1891/0730-0832.37.4.248DOI Listing
July 2018
1 Read

Enhanced astrocyte responses are driven by a genetic risk allele associated with multiple sclerosis.

Nat Commun 2018 12 17;9(1):5337. Epub 2018 Dec 17.

Department of Neurology, Yale School of Medicine, New Haven, CT, 06511, USA.

Epigenetic annotation studies of genetic risk variants for multiple sclerosis (MS) implicate dysfunctional lymphocytes in MS susceptibility; however, the role of central nervous system (CNS) cells remains unclear. We investigated the effect of the risk variant, rs7665090, located near NFKB1, on astrocytes. We demonstrated that chromatin is accessible at the risk locus, a prerequisite for its impact on astroglial function. Read More

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http://dx.doi.org/10.1038/s41467-018-07785-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6297228PMC
December 2018
5 Reads

Standing Tall: Feasibility of a Modified Ride-On Car That Encourages Standing.

Pediatr Phys Ther 2019 01;31(1):E6-E13

Social Mobility Lab (Drs Logan and Catena and Mss Hospodar, Yohn, and Govindan), College of Public Health and Human Sciences, Oregon State University, Corvallis, Oregon; Go Baby Go Lab (Ms Sabet), College of Health Sciences, Cleveland State University, Cleveland, Ohio; Pediatric Mobility Lab and Design Studio (Dr Galloway), Department of Physical Therapy and Biomechanics and Movement Sciences Program, University of Delaware, Newark, Delaware.

Purpose: The purpose of this study was to determine the feasibility of infants with Down syndrome to use a modified ride-on car with seated and standing modes.

Methods: Participants included 4 infants with Down syndrome. Families were asked to provide at least 8 minutes of modified ride-on car driving per day, at least 5 times per week throughout the 9-month intervention. Read More

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http://dx.doi.org/10.1097/PEP.0000000000000568DOI Listing
January 2019
17 Reads

Molecular Mechanisms Directing Spine Outgrowth and Synaptic Partner Selection in .

J Exp Neurosci 2018 2;12:1179069518816088. Epub 2018 Dec 2.

Department of Neurobiology, University of Massachusetts Medical School, Worcester, MA, USA.

The development of the nervous system requires precise outgrowth, extension, and wiring of both axons and dendrites to generate properly functioning neural circuits. The molecular mechanisms that shape neurite development, in particular dendritic development, remain incompletely understood. Dendrites are often highly branched and coated with actin-filled, thorny protrusions, called dendritic spines, that allow for increased numbers of synaptic contacts with neighboring neurons. Read More

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http://dx.doi.org/10.1177/1179069518816088DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6287294PMC
December 2018
21 Reads

Evaluation of Electroencephalogram Using Exact Low-Resolution Electromagnetic Tomography During Photic Driving Response in Patients with Migraine.

Neuropsychobiology 2019 13;77(4):186-191. Epub 2018 Dec 13.

Department of Neurology, Dokkyo Medical University, Mibu, Japan,

Background: Photophobia is a common feature of migraine, which may involve abnormal cortical information processing. In electroencephalograms (EEG), photic driving is known as a reaction to visual stimulation. Both photophobia and photic driving response are present during light stimulation. Read More

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http://dx.doi.org/10.1159/000489715DOI Listing
April 2019
2 Reads

Environmental, economic and socio-cultural risk factors of recurrent seasonal epidemics of cerebrospinal meningitis in Kebbi state, northwestern Nigeria: a qualitative approach.

BMC Public Health 2018 Dec 13;18(Suppl 4):1318. Epub 2018 Dec 13.

World Health Organisation, Country Representative Office, Abuja, Nigeria.

Background: Kebbi State remains the epicentre of the seasonal epidemic meningitis in northwestern Nigeria despite interventions. In this setting, no previous study has been conducted to understand the risk factors of the recurrent meningitis epidemics using qualitative approach. Consequently, this study intends to explore and better understand the environmental, economic and socio-cultural factors of recurrent seasonal epidemic meninigitis using a qualitative approach. Read More

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https://bmcpublichealth.biomedcentral.com/articles/10.1186/s
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http://dx.doi.org/10.1186/s12889-018-6196-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6292165PMC
December 2018
10 Reads

Behind the wheel safety in palliative care: a literature review.

BMJ Support Palliat Care 2018 Dec 6. Epub 2018 Dec 6.

Cicely Saunders Institute of Palliative Care, Policy and Rehabilitation, Brixton, London, UK.

Background: Driving is a complex activity that requires physical abilities and adequate executive and cognitive functioning. There is concern among specialist palliative care services about patients continuing to drive despite having progressive incurable illnesses, comorbidities and medications to manage their symptoms.

Objectives: To determine the quality of literature available about driving that would apply to palliative care patients, specifically in relation to road test or simulated driving scores and neurocognitive testing. Read More

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http://spcare.bmj.com/lookup/doi/10.1136/bmjspcare-2018-0016
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http://dx.doi.org/10.1136/bmjspcare-2018-001639DOI Listing
December 2018
11 Reads

Eomes-expressing T-helper cells as potential target of therapy in chronic neuroinflammation.

Authors:
Shinji Oki

Neurochem Int 2018 Dec 1. Epub 2018 Dec 1.

Department of Immunology, National Institute of Neuroscience, National Center of Neurology and Psychiatry (NCNP), 4-1-1 Ogawahigashi, Kodaira, Tokyo, 187-8502, Japan. Electronic address:

Reserch progresses in understanding the pathogenicity of multiple sclerosis (MS) in the last couple of decade has enabled us to develop new drug entities available in the clinic. However, we still have not succeeded in preventing conversion from relapsing-remitting MS (RR-MS) to secondary progressive MS (SP-MS) and curing this intractable form of MS. Furthermore, diagnosis is usually retrospective and subjective, relying on gradual worsening of neurological signs/symptoms. Read More

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http://dx.doi.org/10.1016/j.neuint.2018.11.023DOI Listing
December 2018
4 Reads

A Case Report of Impaired Driving Performance after a Concussion.

R I Med J (2013) 2018 Dec 3;101(10):56-57. Epub 2018 Dec 3.

Brown University, Department of Emergency Medicine.

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December 2018
1 Read

You're the Flight Surgeon.

Authors:

Aerosp Med Hum Perform 2018 12;89(12):1092-1094

. Read More

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http://dx.doi.org/10.3357/AMHP.5225.2018DOI Listing
December 2018
4 Reads

The Gold Nanocluster Protects Neurons Directly or via Inhibiting Cytotoxic Secretions of Microglia Cell.

J Nanosci Nanotechnol 2019 Apr;19(4):1986-1995

CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China.

Neurodegenerative diseases have become a huge challenge to public health, such as Alzheimer's and Parkinson's diseases. Microglia driving inflammation in the central nervous system (CNS) has been involved in the pathological process of these disorders and could be novel therapy target. However, traditional anti-inflammatory drugs are not effective in alleviating neuroinflammation. Read More

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http://dx.doi.org/10.1166/jnn.2019.15762DOI Listing
April 2019
2 Reads

Elevated cerebrospinal fluid Galectin-9 is associated with central nervous system immune activation and poor cognitive performance in older HIV-infected individuals.

J Neurovirol 2018 Nov 26. Epub 2018 Nov 26.

Department of Tropical Medicine, Medical Microbiology & Pharmacology, John A. Burns School of Medicine, University of Hawai'i, 651 Ilalo St BSB 325, Honolulu, HI, 96813, USA.

We previously reported that galectin-9 (Gal-9), a soluble lectin with immunomodulatory properties, is elevated in plasma during HIV infection and induces HIV transcription. The link between Gal-9 and compromised neuronal function is becoming increasingly evident; however, the association with neuroHIV remains unknown. We measured Gal-9 levels by ELISA in cerebrospinal fluid (CSF) and plasma of 70 HIV-infected (HIV+) adults stratified by age (older > 40 years and younger < 40 years) either ART suppressed or with detectable CSF HIV RNA, including a subgroup with cognitive assessments, and 18 HIV uninfected (HIV-) controls. Read More

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http://link.springer.com/10.1007/s13365-018-0696-3
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http://dx.doi.org/10.1007/s13365-018-0696-3DOI Listing
November 2018
11 Reads

STING-mediated type-I interferons contribute to the neuroinflammatory process and detrimental effects following traumatic brain injury.

J Neuroinflammation 2018 Nov 21;15(1):323. Epub 2018 Nov 21.

Neuropharmacology Laboratory, Department of Pharmacology & Therapeutics, University of Melbourne, Parkville, Melbourne, 3010, Australia.

Background: Traumatic brain injury (TBI) represents a major cause of disability and death worldwide with sustained neuroinflammation and autophagy dysfunction contributing to the cellular damage. Stimulator of interferon genes (STING)-induced type-I interferon (IFN) signalling is known to be essential in mounting the innate immune response against infections and cell injury in the periphery, but its role in the CNS remains unclear. We previously identified the type-I IFN pathway as a key mediator of neuroinflammation and neuronal cell death in TBI. Read More

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http://dx.doi.org/10.1186/s12974-018-1354-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6247615PMC
November 2018
12 Reads

Characterization of iPSCs derived from low grade gliomas revealed early regional chromosomal amplifications during gliomagenesis.

J Neurooncol 2019 Jan 20;141(2):289-301. Epub 2018 Nov 20.

Department of Neurology, University of Alabama at Birmingham, Birmingham, AL, 35294, USA.

Introduction: IDH1 mutation has been identified as an early genetic event driving low grade gliomas (LGGs) and it has been proven to exerts a powerful epigenetic effect. Cells containing IDH1 mutation are refractory to epigenetical reprogramming to iPSC induced by expression of Yamanaka transcription factors, a feature that we employed to study early genetic amplifications or deletions in gliomagenesis.

Methods: We made iPSC clones from freshly surgically resected IDH1 mutant LGGs by forced expression of Yamanaka transcription factors. Read More

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http://dx.doi.org/10.1007/s11060-018-03047-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344247PMC
January 2019
10 Reads

Diet-Induced Hyperinsulinemia as a Key Factor in the Etiology of Both Benign Prostatic Hyperplasia and Essential Hypertension?

Authors:
Wolfgang Kopp

Nutr Metab Insights 2018 8;11:1178638818773072. Epub 2018 May 8.

Former head of the Diagnostikzentrum Graz, Graz, Austria.

Benign prostatic hyperplasia and hypertension are common age-related comorbidities. Although the etiology of benign prostatic hyperplasia (BPH) is still largely unresolved and poorly understood, a significant age-independent association was found between BPH and hypertension, indicating a common pathophysiological factor for both diseases. It has previously been suggested that the development of essential hypertension may be related to diet-induced hyperinsulinemia. Read More

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http://dx.doi.org/10.1177/1178638818773072DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6238249PMC
May 2018
5 Reads

TBX2 is a neuroblastoma core regulatory circuitry component enhancing MYCN/FOXM1 reactivation of DREAM targets.

Nat Commun 2018 11 19;9(1):4866. Epub 2018 Nov 19.

Center for Medical Genetics, Ghent University, Ghent, 9000, Belgium.

Chromosome 17q gains are almost invariably present in high-risk neuroblastoma cases. Here, we perform an integrative epigenomics search for dosage-sensitive transcription factors on 17q marked by H3K27ac defined super-enhancers and identify TBX2 as top candidate gene. We show that TBX2 is a constituent of the recently established core regulatory circuitry in neuroblastoma with features of a cell identity transcription factor, driving proliferation through activation of p21-DREAM repressed FOXM1 target genes. Read More

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http://www.nature.com/articles/s41467-018-06699-9
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http://dx.doi.org/10.1038/s41467-018-06699-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6242972PMC
November 2018
35 Reads

Different Fgfs have distinct roles in regulating neurogenesis after spinal cord injury in zebrafish.

Neural Dev 2018 11 17;13(1):24. Epub 2018 Nov 17.

Australian Regenerative Medicine Institute, Monash University, Clayton, VIC, 3800, Australia.

Background: Despite conserved developmental processes and organization of the vertebrate central nervous system, only some vertebrates including zebrafish can efficiently regenerate neural damage including after spinal cord injury. The mammalian spinal cord shows very limited regeneration and neurogenesis, resulting in permanent life-long functional impairment. Therefore, there is an urgent need to identify the cellular and molecular mechanisms that can drive efficient vertebrate neurogenesis following injury. Read More

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http://dx.doi.org/10.1186/s13064-018-0122-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6240426PMC
November 2018
3 Reads

Seizures occurring while driving in patients with and without diagnosis of epilepsy: Frequency and association with automobile accidents.

J Clin Neurosci 2019 Jan 13;59:75-78. Epub 2018 Nov 13.

Department of Neurology, Saiseikai Utsunomiya Hospital, Utsunomiya, Japan.

Seizure may occur during any human activity, including driving. The objectives of this study were to report the frequency of seizure occurring while driving, clarify patient characteristics and analyze the behavioral patterns of drivers afflicted by seizure. A single-center, retrospective study was conducted using prospectively acquired data. Read More

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http://dx.doi.org/10.1016/j.jocn.2018.11.003DOI Listing
January 2019

The History and Horizons of Microscale Neural Interfaces.

Micromachines (Basel) 2018 Sep 6;9(9). Epub 2018 Sep 6.

Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA 15261, USA.

Microscale neural technologies interface with the nervous system to record and stimulate brain tissue with high spatial and temporal resolution. These devices are being developed to understand the mechanisms that govern brain function, plasticity and cognitive learning, treat neurological diseases, or monitor and restore functions over the lifetime of the patient. Despite decades of use in basic research over days to months, and the growing prevalence of neuromodulation therapies, in many cases the lack of knowledge regarding the fundamental mechanisms driving activation has dramatically limited our ability to interpret data or fine-tune design parameters to improve long-term performance. Read More

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http://www.mdpi.com/2072-666X/9/9/445
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http://dx.doi.org/10.3390/mi9090445DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6187275PMC
September 2018
16 Reads

A cancer tissue-specific FAM72 expression profile defines a novel glioblastoma multiform (GBM) gene-mutation signature.

J Neurooncol 2019 Jan 9;141(1):57-70. Epub 2018 Nov 9.

Graduate School of Biomedical Science and Engineering, Hanyang University, 222 Wangsimni-ro, Seongdong-gu, Seoul, 133-791, Republic of Korea.

Introduction: Glioblastoma multiform (GBM) is a neural stem cell (NSC)-derived malignant brain tumor with complex genetic alterations challenging clinical treatments. FAM72 is a NSC-specific protein comprised of four paralogous genes (FAM72 A-D) in the human genome, but its functional tumorigenic significance is unclear.

Methods: We conducted an in-depth expression and somatic mutation data analysis of FAM72 (A-D) in GBM using the comprehensive human clinical cancer study database cBioPortal [including The Cancer Genome Atlas (TCGA)]. Read More

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http://link.springer.com/10.1007/s11060-018-03029-3
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http://dx.doi.org/10.1007/s11060-018-03029-3DOI Listing
January 2019
4 Reads
3.070 Impact Factor

Leptomeningeal carcinomatosis as primary presentation of metastatic urothelial cancer.

BMJ Case Rep 2018 Nov 8;2018. Epub 2018 Nov 8.

Department of Neurology, University of Florida College of Medicine, Gainesville, Florida, USA.

Leptomeningeal spread of carcinoma, referred to here as leptomeningeal carcinomatosis, is an uncommon complication of many cancer types. Its manifestations as the presenting symptoms of a new cancer diagnosis is even less common. This case describes the manifestations of leptomeningeal spread of urothelial carcinoma with review of pathophysiology driving the presenting symptoms of hypertension and headache. Read More

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http://casereports.bmj.com/lookup/doi/10.1136/bcr-2017-22415
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http://dx.doi.org/10.1136/bcr-2017-224150DOI Listing
November 2018
6 Reads

Visual field defects after radiosurgery versus temporal lobectomy for mesial temporal lobe epilepsy: Findings of the ROSE trial.

Seizure 2018 Dec 31;63:62-67. Epub 2018 Oct 31.

University of California San Diego, San Diego, CA, United States.

Purpose: Stereotactic radiosurgery (SRS) may be an alternative to anterior temporal lobectomy (ATL) for mesial temporal lobe epilepsy (MTLE). Visual field defects (VFD) occur in 9-100% of patients following open surgery for MTLE. Postoperative VFD after minimally invasive versus open surgery may differ. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10591311183035
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http://dx.doi.org/10.1016/j.seizure.2018.10.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413861PMC
December 2018
13 Reads

Comprehensive analysis of Reverse Phase Protein Array data reveals characteristic unique proteomic signatures for glioblastoma subtypes.

Gene 2019 Feb 25;685:85-95. Epub 2018 Oct 25.

Department of Bio-Medical Sciences, School of Biosciences and Technology, VIT University, Vellore 632014, India. Electronic address:

The most common and lethal type of intracranial tumors include the astrocytomas. Grade IV astrocytoma or Glioblastoma (GBM) is highly aggressive and treatment-refractory with a median survival of only 14 to 16 months. Molecular profiling of GBMs reveals a high degree of intra- and inter-tumoral heterogeneity, and hence it is important to understand the important signalling axes that get deregulated in different GBM subtypes to provide effective tailor-made therapies. Read More

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http://dx.doi.org/10.1016/j.gene.2018.10.069DOI Listing
February 2019
3 Reads

Depression and Alzheimer's Disease Biomarkers Predict Driving Decline.

J Alzheimers Dis 2018 ;66(3):1213-1221

Charles F. and Joanne Knight Alzheimer's Disease Research Center, Washington University, School of Medicine, St. Louis, MO, USA.

Background: Symptomatic Alzheimer's disease (AD) and depression independently increase crash risk. Additionally, depression is both a risk factor for and a consequence of AD.

Objective: To examine whether a depression diagnosis, antidepressant use, and preclinical AD are associated with driving decline among cognitively normal older adults. Read More

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http://dx.doi.org/10.3233/JAD-180564DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330210PMC
January 2018
14 Reads

Development of a community-based golf and exercise program for people with Parkinson's disease.

Complement Ther Clin Pract 2018 Nov 24;33:149-155. Epub 2018 Sep 24.

2001 Newburg Road, Nolen C. Allen Hall, Physical Therapy Program, School of Movement and Rehabilitation Sciences, College of Health Professions, Bellarmine University, Louisville, KY, 40205, USA. Electronic address:

Individuals with Parkinson's disease (PD) typically display symptoms of rigidity, bradykinesia, and postural instability that can limit participation in recreational activities. The purpose of this clinical report is to describe the development, implementation, and outcomes of a novel and innovative community-based golf and exercise program for individuals with PD. In response to community interest, the program was developed through a unique partnership that blended the expertise of physical therapists and golf professionals. Read More

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http://dx.doi.org/10.1016/j.ctcp.2018.09.006DOI Listing
November 2018
42 Reads

Blocking TNFα-driven astrocyte purinergic signaling restores normal synaptic activity during epileptogenesis.

Glia 2018 12 5;66(12):2673-2683. Epub 2018 Nov 5.

Neuron-glia interactions group, INSERM U1128, Paris Descartes University, Paris, France.

Epilepsy is characterized by unpredictable recurrent seizures resulting from abnormal neuronal excitability. Increasing evidence indicates that aberrant astrocyte signaling to neurons plays an important role in driving the network hyperexcitability, but the underlying mechanism that alters glial signaling in epilepsy remains unknown. Increase in glutamate release by astrocytes participates in the onset and progression of seizures. Read More

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http://doi.wiley.com/10.1002/glia.23519
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http://dx.doi.org/10.1002/glia.23519DOI Listing
December 2018
6 Reads